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Compile Data Set for Download or QSAR

Found 207 hits with Last Name = 'sakuraba' and Initial = 'a'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249779
PNG
(3-[(4S,5S)-4-(4-Fluorophenyl)-4-(6-fluoro-3-pyridy...)
Show SMILES C[C@@H]1NC(=N[C@@]1(c1ccc(F)cc1)c1ccc(F)nc1)c1cccc(c1)C#N |r,c:3|
Show InChI InChI=1S/C22H16F2N4/c1-14-22(17-5-8-19(23)9-6-17,18-7-10-20(24)26-13-18)28-21(27-14)16-4-2-3-15(11-16)12-25/h2-11,13-14H,1H3,(H,27,28)/t14-,22-/m0/s1
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0.800n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249806
PNG
(4-[(4S,5S)-4-(4-Fluorophenyl)-4-(6-fluoro-3-pyridy...)
Show SMILES C[C@@H]1NC(=N[C@@]1(c1ccc(F)cc1)c1ccc(F)nc1)c1ccnc(c1)C#N |r,c:3|
Show InChI InChI=1S/C21H15F2N5/c1-13-21(15-2-5-17(22)6-3-15,16-4-7-19(23)26-12-16)28-20(27-13)14-8-9-25-18(10-14)11-24/h2-10,12-13H,1H3,(H,27,28)/t13-,21-/m0/s1
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1n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249739
PNG
(2-[(5S)-4,4-Bis(4-fluorophenyl)-5-methyl-4,5-dihyd...)
Show SMILES C[C@@H]1NC(=NC1(c1ccc(F)cc1)c1ccc(F)cc1)c1cc(ccn1)C#N |r,c:3|
Show InChI InChI=1S/C22H16F2N4/c1-14-22(16-2-6-18(23)7-3-16,17-4-8-19(24)9-5-17)28-21(27-14)20-12-15(13-25)10-11-26-20/h2-12,14H,1H3,(H,27,28)/t14-/m0/s1
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1n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249777
PNG
(2-{(4S,5S)-4-(4-Fluorophenyl)-5-methyl-4-[6-(methy...)
Show SMILES COc1ccc(cn1)[C@@]1(N=C(N[C@H]1C)c1cc(ccn1)C#N)c1ccc(F)cc1 |r,c:10|
Show InChI InChI=1S/C22H18FN5O/c1-14-22(16-3-6-18(23)7-4-16,17-5-8-20(29-2)26-13-17)28-21(27-14)19-11-15(12-24)9-10-25-19/h3-11,13-14H,1-2H3,(H,27,28)/t14-,22-/m0/s1
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1.10n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249758
PNG
(2-[(4S,5S)-4-(4-Fluorophenyl)-4-(6-fluoro-3-pyridy...)
Show SMILES C[C@@H]1NC(=N[C@@]1(c1ccc(F)cc1)c1ccc(F)nc1)c1cc(ccn1)C#N |r,c:3|
Show InChI InChI=1S/C21H15F2N5/c1-13-21(15-2-5-17(22)6-3-15,16-4-7-19(23)26-12-16)28-20(27-13)18-10-14(11-24)8-9-25-18/h2-10,12-13H,1H3,(H,27,28)/t13-,21-/m0/s1
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1.30n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249833
PNG
(6-[(4S,5S)-4-(4-Fluorophenyl)-4-(6-fluoro-3-pyridy...)
Show SMILES C[C@@H]1NC(=N[C@@]1(c1ccc(F)cc1)c1ccc(F)nc1)c1cccc(=O)[nH]1 |r,c:3|
Show InChI InChI=1S/C20H16F2N4O/c1-12-20(13-5-8-15(21)9-6-13,14-7-10-17(22)23-11-14)26-19(24-12)16-3-2-4-18(27)25-16/h2-12H,1H3,(H,24,26)(H,25,27)/t12-,20-/m0/s1
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1.40n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249775
PNG
(2-[(4R,5S)-4-(4-Fluorophenyl)-4-(6-fluoro-3-pyridy...)
Show SMILES C[C@@H]1NC(=N[C@]1(c1ccc(F)cc1)c1ccc(F)nc1)c1cc(ccn1)C#N |r,c:3|
Show InChI InChI=1S/C21H15F2N5/c1-13-21(15-2-5-17(22)6-3-15,16-4-7-19(23)26-12-16)28-20(27-13)18-10-14(11-24)8-9-25-18/h2-10,12-13H,1H3,(H,27,28)/t13-,21+/m0/s1
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1.60n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249830
PNG
(4-Chloro-2-[(4S,5S)-4-(4-fluorophenyl)-4-(6-fluoro...)
Show SMILES C[C@@H]1NC(=N[C@@]1(c1ccc(F)cc1)c1ccc(F)nc1)c1cc(Cl)ccn1 |r,c:3|
Show InChI InChI=1S/C20H15ClF2N4/c1-12-20(13-2-5-16(22)6-3-13,14-4-7-18(23)25-11-14)27-19(26-12)17-10-15(21)8-9-24-17/h2-12H,1H3,(H,26,27)/t12-,20-/m0/s1
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1.80n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249757
PNG
(2-[(5S)-4,4-Bis(4-fluorophenyl)-5-methyl-4,5-dihyd...)
Show SMILES C[C@@H]1NC(=NC1(c1ccc(F)cc1)c1ccc(F)cc1)c1cnccn1 |r,c:3|
Show InChI InChI=1S/C20H16F2N4/c1-13-20(14-2-6-16(21)7-3-14,15-4-8-17(22)9-5-15)26-19(25-13)18-12-23-10-11-24-18/h2-13H,1H3,(H,25,26)/t13-/m0/s1
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1.90n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249737
PNG
(2-(4,4-bis(4-fluorophenyl)-4,5-dihydro-1H-imidazol...)
Show SMILES Fc1ccc(cc1)C1(CNC(=N1)c1cc(ccn1)C#N)c1ccc(F)cc1 |c:11|
Show InChI InChI=1S/C21H14F2N4/c22-17-5-1-15(2-6-17)21(16-3-7-18(23)8-4-16)13-26-20(27-21)19-11-14(12-24)9-10-25-19/h1-11H,13H2,(H,26,27)
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2n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249865
PNG
(2-Fluoro-5-[(4S,5S)-4-(4-fluorophenyl)-5-methyl-2-...)
Show SMILES C[C@@H]1NC(=N[C@@]1(c1ccc(F)cc1)c1ccc(F)nc1)c1cnsn1 |r,c:3|
Show InChI InChI=1S/C17H13F2N5S/c1-10-17(11-2-5-13(18)6-3-11,12-4-7-15(19)20-8-12)23-16(22-10)14-9-21-25-24-14/h2-10H,1H3,(H,22,23)/t10-,17-/m0/s1
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2n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249832
PNG
(2-[(4S,5S)-4-(4-Fluorophenyl)-4-(6-fluoro-3-pyridy...)
Show SMILES C[C@@H]1NC(=N[C@@]1(c1ccc(F)cc1)c1ccc(F)nc1)c1cnccn1 |r,c:3|
Show InChI InChI=1S/C19H15F2N5/c1-12-19(13-2-5-15(20)6-3-13,14-4-7-17(21)24-10-14)26-18(25-12)16-11-22-8-9-23-16/h2-12H,1H3,(H,25,26)/t12-,19-/m0/s1
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2.20n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249869
PNG
(3-oxo-N-(5-phenylpyrazin-2-yl)-3H-spiro[isobenzofu...)
Show SMILES O=C(Nc1cnc(cn1)-c1ccccc1)N1CCC2(CC1)OC(=O)c1ccccc21
Show InChI InChI=1S/C23H20N4O3/c28-21-17-8-4-5-9-18(17)23(30-21)10-12-27(13-11-23)22(29)26-20-15-24-19(14-25-20)16-6-2-1-3-7-16/h1-9,14-15H,10-13H2,(H,25,26,29)
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2.40n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249803
PNG
(2-Fluoro-5-{(4S,5S)-4-(4-fluorophenyl)-5-methyl-2-...)
Show SMILES C[C@@H]1NC(=N[C@@]1(c1ccc(F)cc1)c1ccc(F)nc1)c1cccc(c1)S(C)(=O)=O |r,c:3|
Show InChI InChI=1S/C22H19F2N3O2S/c1-14-22(16-6-9-18(23)10-7-16,17-8-11-20(24)25-13-17)27-21(26-14)15-4-3-5-19(12-15)30(2,28)29/h3-14H,1-2H3,(H,26,27)/t14-,22-/m0/s1
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2.5n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249829
PNG
(2-[(4S,5S)-4-(4-Fluorophenyl)-4-(6-fluoro-3-pyridy...)
Show SMILES COc1ccnc(c1)C1=N[C@@]([C@H](C)N1)(c1ccc(F)cc1)c1ccc(F)nc1 |r,t:9|
Show InChI InChI=1S/C21H18F2N4O/c1-13-21(14-3-6-16(22)7-4-14,15-5-8-19(23)25-12-15)27-20(26-13)18-11-17(28-2)9-10-24-18/h3-13H,1-2H3,(H,26,27)/t13-,21-/m0/s1
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2.5n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249754
PNG
(2-[(5S)-5-Ethyl-4,4-bis(4-fluorophenyl)-4,5-dihydr...)
Show SMILES CC[C@@H]1NC(=NC1(c1ccc(F)cc1)c1ccc(F)cc1)c1cc(ccn1)C#N |r,c:4|
Show InChI InChI=1S/C23H18F2N4/c1-2-21-23(16-3-7-18(24)8-4-16,17-5-9-19(25)10-6-17)29-22(28-21)20-13-15(14-26)11-12-27-20/h3-13,21H,2H2,1H3,(H,28,29)/t21-/m0/s1
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2.60n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50123720
PNG
(2,3-Dihydro-1H-cyclopenta[a]naphthalene-2-carboxyl...)
Show SMILES COc1ccc(cc1OC)-c1cc(NC(=O)C2Cc3ccc4ccccc4c3C2)[nH]n1
Show InChI InChI=1S/C25H23N3O3/c1-30-22-10-9-17(13-23(22)31-2)21-14-24(28-27-21)26-25(29)18-11-16-8-7-15-5-3-4-6-19(15)20(16)12-18/h3-10,13-14,18H,11-12H2,1-2H3,(H2,26,27,28,29)
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2.80n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]-PYY binding to human recombinant Neuropeptide Y receptor type 5 in LMtk-cells


J Med Chem 46: 666-9 (2003)


Article DOI: 10.1021/jm025513q
BindingDB Entry DOI: 10.7270/Q2028QWP
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249756
PNG
(2-[(5R)-4,4-Bis(4-fluorophenyl)-5-(hydroxymethyl)-...)
Show SMILES OC[C@@H]1NC(=NC1(c1ccc(F)cc1)c1ccc(F)cc1)c1cc(ccn1)C#N |r,c:4|
Show InChI InChI=1S/C22H16F2N4O/c23-17-5-1-15(2-6-17)22(16-3-7-18(24)8-4-16)20(13-29)27-21(28-22)19-11-14(12-25)9-10-26-19/h1-11,20,29H,13H2,(H,27,28)/t20-/m0/s1
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3n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249776
PNG
(2-[(5S)-4,4-Bis(6-fluoro-3-pyridyl)-5-methyl-4,5-d...)
Show SMILES C[C@@H]1NC(=NC1(c1ccc(F)nc1)c1ccc(F)nc1)c1cc(ccn1)C#N |r,c:3|
Show InChI InChI=1S/C20H14F2N6/c1-12-20(14-2-4-17(21)25-10-14,15-3-5-18(22)26-11-15)28-19(27-12)16-8-13(9-23)6-7-24-16/h2-8,10-12H,1H3,(H,27,28)/t12-/m0/s1
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3.10n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249804
PNG
(5-[(4S,5S)-4-(4-Fluorophenyl)-4-(6-fluoro-3-pyridy...)
Show SMILES C[C@@H]1NC(=N[C@@]1(c1ccc(F)cc1)c1ccc(F)nc1)c1cncc(c1)C#N |r,c:3|
Show InChI InChI=1S/C21H15F2N5/c1-13-21(16-2-5-18(22)6-3-16,17-4-7-19(23)26-12-17)28-20(27-13)15-8-14(9-24)10-25-11-15/h2-8,10-13H,1H3,(H,27,28)/t13-,21-/m0/s1
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3.20n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50123724
PNG
(2,3-Dihydro-1H-cyclopenta[a]naphthalene-2-carboxyl...)
Show SMILES CCc1cc(ccn1)-c1cc(NC(=O)C2Cc3ccc4ccccc4c3C2)[nH]n1
Show InChI InChI=1S/C24H22N4O/c1-2-19-12-17(9-10-25-19)22-14-23(28-27-22)26-24(29)18-11-16-8-7-15-5-3-4-6-20(15)21(16)13-18/h3-10,12,14,18H,2,11,13H2,1H3,(H2,26,27,28,29)
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3.5n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]-PYY binding to human recombinant Neuropeptide Y receptor type 5 in LMtk-cells


J Med Chem 46: 666-9 (2003)


Article DOI: 10.1021/jm025513q
BindingDB Entry DOI: 10.7270/Q2028QWP
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249807
PNG
(2-[(4S,5S)-4-(4-Fluorophenyl)-4-(6-fluoro-3-pyridy...)
Show SMILES C[C@@H]1NC(=N[C@@]1(c1ccc(F)cc1)c1ccc(F)nc1)c1nccc(n1)C#N |r,c:3|
Show InChI InChI=1S/C20H14F2N6/c1-12-20(13-2-5-15(21)6-3-13,14-4-7-17(22)25-11-14)28-19(26-12)18-24-9-8-16(10-23)27-18/h2-9,11-12H,1H3,(H,26,28)/t12-,20-/m0/s1
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3.60n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249866
PNG
(2-Fluoro-5-[(4S,5S)-4-(4-fluorophenyl)-5-methyl-2-...)
Show SMILES C[C@@H]1NC(=N[C@@]1(c1ccc(F)cc1)c1ccc(F)nc1)c1nccs1 |r,c:3|
Show InChI InChI=1S/C18H14F2N4S/c1-11-18(12-2-5-14(19)6-3-12,13-4-7-15(20)22-10-13)24-16(23-11)17-21-8-9-25-17/h2-11H,1H3,(H,23,24)/t11-,18-/m0/s1
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4.10n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249738
PNG
(2-(4,4-bis(4-fluorophenyl)-4,5-dihydro-1H-imidazol...)
Show SMILES Fc1ccc(cc1)C1(CNC(=N1)c1cnccn1)c1ccc(F)cc1 |c:11|
Show InChI InChI=1S/C19H14F2N4/c20-15-5-1-13(2-6-15)19(14-3-7-16(21)8-4-14)12-24-18(25-19)17-11-22-9-10-23-17/h1-11H,12H2,(H,24,25)
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4.30n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249831
PNG
(2-((4S,5S)-4-(4-fluorophenyl)-4-(6-fluoropyridin-3...)
Show SMILES C[C@@H]1NC(=N[C@@]1(c1ccc(F)cc1)c1ccc(F)nc1)c1cc(ccn1)C(N)=O |r,c:3|
Show InChI InChI=1S/C21H17F2N5O/c1-12-21(14-2-5-16(22)6-3-14,15-4-7-18(23)26-11-15)28-20(27-12)17-10-13(19(24)29)8-9-25-17/h2-12H,1H3,(H2,24,29)(H,27,28)/t12-,21-/m0/s1
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5.10n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249805
PNG
(6-[(4S,5S)-4-(4-Fluorophenyl)-4-(6-fluoro-3-pyridy...)
Show SMILES C[C@@H]1NC(=N[C@@]1(c1ccc(F)cc1)c1ccc(F)nc1)c1cccc(n1)C#N |r,c:3|
Show InChI InChI=1S/C21H15F2N5/c1-13-21(14-5-8-16(22)9-6-14,15-7-10-19(23)25-12-15)28-20(26-13)18-4-2-3-17(11-24)27-18/h2-10,12-13H,1H3,(H,26,28)/t13-,21-/m0/s1
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5.90n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50123724
PNG
(2,3-Dihydro-1H-cyclopenta[a]naphthalene-2-carboxyl...)
Show SMILES CCc1cc(ccn1)-c1cc(NC(=O)C2Cc3ccc4ccccc4c3C2)[nH]n1
Show InChI InChI=1S/C24H22N4O/c1-2-19-12-17(9-10-25-19)22-14-23(28-27-22)26-24(29)18-11-16-8-7-15-5-3-4-6-20(15)21(16)13-18/h3-10,12,14,18H,2,11,13H2,1H3,(H2,26,27,28,29)
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7.30n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]-PYY binding to human recombinant Neuropeptide Y receptor type 5 in LMtk-cells


J Med Chem 46: 666-9 (2003)


Article DOI: 10.1021/jm025513q
BindingDB Entry DOI: 10.7270/Q2028QWP
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50123724
PNG
(2,3-Dihydro-1H-cyclopenta[a]naphthalene-2-carboxyl...)
Show SMILES CCc1cc(ccn1)-c1cc(NC(=O)C2Cc3ccc4ccccc4c3C2)[nH]n1
Show InChI InChI=1S/C24H22N4O/c1-2-19-12-17(9-10-25-19)22-14-23(28-27-22)26-24(29)18-11-16-8-7-15-5-3-4-6-20(15)21(16)13-18/h3-10,12,14,18H,2,11,13H2,1H3,(H2,26,27,28,29)
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7.30n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]-PYY binding to human recombinant Neuropeptide Y receptor type 5 in LMtk-cells


J Med Chem 46: 666-9 (2003)


Article DOI: 10.1021/jm025513q
BindingDB Entry DOI: 10.7270/Q2028QWP
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50073047
PNG
(CHEMBL291666 | N-[5-(3,4-Dimethoxy-phenyl)-1H-pyra...)
Show SMILES COc1ccc(cc1OC)-c1cc(NC(=O)Cc2ccc3ccccc3c2)[nH]n1
Show InChI InChI=1S/C23H21N3O3/c1-28-20-10-9-18(13-21(20)29-2)19-14-22(26-25-19)24-23(27)12-15-7-8-16-5-3-4-6-17(16)11-15/h3-11,13-14H,12H2,1-2H3,(H2,24,25,26,27)
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8.30n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]-PYY binding to human recombinant Neuropeptide Y receptor type 5 in LMtk-cells


J Med Chem 46: 666-9 (2003)


Article DOI: 10.1021/jm025513q
BindingDB Entry DOI: 10.7270/Q2028QWP
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249755
PNG
(2-[(5S)-4,4-Bis(4-fluorophenyl)-5-propyl-4,5-dihyd...)
Show SMILES CCC[C@@H]1NC(=NC1(c1ccc(F)cc1)c1ccc(F)cc1)c1cc(ccn1)C#N |r,c:5|
Show InChI InChI=1S/C24H20F2N4/c1-2-3-22-24(17-4-8-19(25)9-5-17,18-6-10-20(26)11-7-18)30-23(29-22)21-14-16(15-27)12-13-28-21/h4-14,22H,2-3H2,1H3,(H,29,30)/t22-/m0/s1
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8.60n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50123729
PNG
(2,3-Dihydro-1H-cyclopenta[a]naphthalene-2-carboxyl...)
Show SMILES O=C(Nc1cc(n[nH]1)-c1ccncc1)C1Cc2ccc3ccccc3c2C1
Show InChI InChI=1S/C22H18N4O/c27-22(24-21-13-20(25-26-21)15-7-9-23-10-8-15)17-11-16-6-5-14-3-1-2-4-18(14)19(16)12-17/h1-10,13,17H,11-12H2,(H2,24,25,26,27)
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10n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]-PYY binding to human recombinant Neuropeptide Y receptor type 5 in LMtk-cells


J Med Chem 46: 666-9 (2003)


Article DOI: 10.1021/jm025513q
BindingDB Entry DOI: 10.7270/Q2028QWP
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50261956
PNG
(9'-(6-Hydroxy-8-oxospiro[3.5]non-7-yl)-4',9'-dihyd...)
Show SMILES O=C1CC2(CCC2)CC(=O)C1C1C2=C(CC3(CCC3)CC2=O)Oc2ccccc12 |t:14|
Show InChI InChI=1S/C25H26O4/c26-16-11-24(7-3-8-24)12-17(27)22(16)21-15-5-1-2-6-19(15)29-20-14-25(9-4-10-25)13-18(28)23(20)21/h1-2,5-6,21-22H,3-4,7-14H2
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14n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in thymidine kinase deficient human LM cells


J Med Chem 51: 4765-70 (2008)


Article DOI: 10.1021/jm8003587
BindingDB Entry DOI: 10.7270/Q2J96664
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50262553
PNG
((9S)-9-(2-Hydroxy-4,4-dimethyl-6-oxo-1-cyclohexen-...)
Show SMILES CC1(C)CC(=O)C([C@H]2C3=C(CC(C)(C)CC3=O)Oc3ccccc23)C(=O)C1 |r,t:8|
Show InChI InChI=1S/C23H26O4/c1-22(2)9-14(24)20(15(25)10-22)19-13-7-5-6-8-17(13)27-18-12-23(3,4)11-16(26)21(18)19/h5-8,19-20H,9-12H2,1-4H3/t19-/m0/s1
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14n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in thymidine kinase deficient human LM cells


J Med Chem 51: 4765-70 (2008)


Article DOI: 10.1021/jm8003587
BindingDB Entry DOI: 10.7270/Q2J96664
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50409778
PNG
(CHEMBL2110162)
Show SMILES OC(=O)CCc1cccc(CC(=O)Nc2cc(n[nH]2)-c2ccc(Cl)cc2)c1
Show InChI InChI=1S/C20H18ClN3O3/c21-16-7-5-15(6-8-16)17-12-18(24-23-17)22-19(25)11-14-3-1-2-13(10-14)4-9-20(26)27/h1-3,5-8,10,12H,4,9,11H2,(H,26,27)(H2,22,23,24,25)
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16n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]-PYY binding to human recombinant Neuropeptide Y receptor type 5 in LMtk-cells


J Med Chem 46: 666-9 (2003)


Article DOI: 10.1021/jm025513q
BindingDB Entry DOI: 10.7270/Q2028QWP
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50262001
PNG
(9'-(7-Hydroxy-9-oxospiro[4.5]dec-8-yl)-4',9'-dihyd...)
Show SMILES O=C1CC2(CCCC2)CC(=O)C1C1C2=C(CC3(CCCC3)CC2=O)Oc2ccccc12 |t:15|
Show InChI InChI=1S/C27H30O4/c28-18-13-26(9-3-4-10-26)14-19(29)24(18)23-17-7-1-2-8-21(17)31-22-16-27(11-5-6-12-27)15-20(30)25(22)23/h1-2,7-8,23-24H,3-6,9-16H2
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17n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in thymidine kinase deficient human LM cells


J Med Chem 51: 4765-70 (2008)


Article DOI: 10.1021/jm8003587
BindingDB Entry DOI: 10.7270/Q2J96664
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50261955
PNG
(9-(4,4-Diethyl-2-hydroxy-6-oxocyclohexyl)-3,3-diet...)
Show SMILES CCC1(CC)CC(=O)C(C2C3=C(CC(CC)(CC)CC3=O)Oc3ccccc23)C(=O)C1 |t:10|
Show InChI InChI=1S/C27H34O4/c1-5-26(6-2)13-18(28)24(19(29)14-26)23-17-11-9-10-12-21(17)31-22-16-27(7-3,8-4)15-20(30)25(22)23/h9-12,23-24H,5-8,13-16H2,1-4H3
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20n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in thymidine kinase deficient human LM cells


J Med Chem 51: 4765-70 (2008)


Article DOI: 10.1021/jm8003587
BindingDB Entry DOI: 10.7270/Q2J96664
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50262002
PNG
(9'-(2-Hydroxy-4-oxospiro[5.5]undec-3-yl)-4',9'-dih...)
Show SMILES O=C1CC2(CCCCC2)CC(=O)C1C1C2=C(CC3(CCCCC3)CC2=O)Oc2ccccc12 |t:16|
Show InChI InChI=1S/C29H34O4/c30-20-15-28(11-5-1-6-12-28)16-21(31)26(20)25-19-9-3-4-10-23(19)33-24-18-29(13-7-2-8-14-29)17-22(32)27(24)25/h3-4,9-10,25-26H,1-2,5-8,11-18H2
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24n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in thymidine kinase deficient human LM cells


J Med Chem 51: 4765-70 (2008)


Article DOI: 10.1021/jm8003587
BindingDB Entry DOI: 10.7270/Q2J96664
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50261897
PNG
(6-Fluoro-9-(2-hydroxy-4,4-dimethyl-6-oxocyclohexyl...)
Show SMILES CC1(C)CC(=O)C(C2C3=C(CC(C)(C)CC3=O)Oc3cc(F)ccc23)C(=O)C1 |t:8|
Show InChI InChI=1S/C23H25FO4/c1-22(2)8-14(25)20(15(26)9-22)19-13-6-5-12(24)7-17(13)28-18-11-23(3,4)10-16(27)21(18)19/h5-7,19-20H,8-11H2,1-4H3
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29n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in thymidine kinase deficient human LM cells


J Med Chem 51: 4765-70 (2008)


Article DOI: 10.1021/jm8003587
BindingDB Entry DOI: 10.7270/Q2J96664
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM86733
PNG
(5,5-DIMETHYL-2-(2,3,4,9-TETRAHYDRO-3,3-DIMETHYL-1O...)
Show SMILES CC1(C)CC(=O)C(C2C3=C(CC(C)(C)CC3=O)Oc3ccccc23)C(=O)C1 |t:8|
Show InChI InChI=1S/C23H26O4/c1-22(2)9-14(24)20(15(25)10-22)19-13-7-5-6-8-17(13)27-18-12-23(3,4)11-16(26)21(18)19/h5-8,19-20H,9-12H2,1-4H3
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33n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM86733
PNG
(5,5-DIMETHYL-2-(2,3,4,9-TETRAHYDRO-3,3-DIMETHYL-1O...)
Show SMILES CC1(C)CC(=O)C(C2C3=C(CC(C)(C)CC3=O)Oc3ccccc23)C(=O)C1 |t:8|
Show InChI InChI=1S/C23H26O4/c1-22(2)9-14(24)20(15(25)10-22)19-13-7-5-6-8-17(13)27-18-12-23(3,4)11-16(26)21(18)19/h5-8,19-20H,9-12H2,1-4H3
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33n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in thymidine kinase deficient human LM cells


J Med Chem 51: 4765-70 (2008)


Article DOI: 10.1021/jm8003587
BindingDB Entry DOI: 10.7270/Q2J96664
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50123735
PNG
(CHEMBL160443 | Indan-2-carboxylic acid [5-(3,4-dim...)
Show SMILES COc1ccc(cc1OC)-c1cc(NC(=O)C2Cc3ccccc3C2)[nH]n1
Show InChI InChI=1S/C21H21N3O3/c1-26-18-8-7-15(11-19(18)27-2)17-12-20(24-23-17)22-21(25)16-9-13-5-3-4-6-14(13)10-16/h3-8,11-12,16H,9-10H2,1-2H3,(H2,22,23,24,25)
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33n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]-PYY binding to human recombinant Neuropeptide Y receptor type 5 in LMtk-cells


J Med Chem 46: 666-9 (2003)


Article DOI: 10.1021/jm025513q
BindingDB Entry DOI: 10.7270/Q2028QWP
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50261724
PNG
(6-Chloro-9-(2-hydroxy-4,4-dimethyl-6-oxocyclohexyl...)
Show SMILES CC1(C)CC(=O)C(C2C3=C(CC(C)(C)CC3=O)Oc3cc(Cl)ccc23)C(=O)C1 |t:8|
Show InChI InChI=1S/C23H25ClO4/c1-22(2)8-14(25)20(15(26)9-22)19-13-6-5-12(24)7-17(13)28-18-11-23(3,4)10-16(27)21(18)19/h5-7,19-20H,8-11H2,1-4H3
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34n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in thymidine kinase deficient human LM cells


J Med Chem 51: 4765-70 (2008)


Article DOI: 10.1021/jm8003587
BindingDB Entry DOI: 10.7270/Q2J96664
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50261898
PNG
(5-Fluoro-9-(2-hydroxy-4,4-dimethyl-6-oxocyclohexyl...)
Show SMILES CC1(C)CC(=O)C(C2C3=C(CC(C)(C)CC3=O)Oc3c(F)cccc23)C(=O)C1 |t:8|
Show InChI InChI=1S/C23H25FO4/c1-22(2)8-14(25)19(15(26)9-22)18-12-6-5-7-13(24)21(12)28-17-11-23(3,4)10-16(27)20(17)18/h5-7,18-19H,8-11H2,1-4H3
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34n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in thymidine kinase deficient human LM cells


J Med Chem 51: 4765-70 (2008)


Article DOI: 10.1021/jm8003587
BindingDB Entry DOI: 10.7270/Q2J96664
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50261952
PNG
(6-Bromo-9-(2-hydroxy-4,4-dimethyl-6-oxocyclohexyl)...)
Show SMILES CC1(C)CC(=O)C(C2C3=C(CC(C)(C)CC3=O)Oc3cc(Br)ccc23)C(=O)C1 |t:8|
Show InChI InChI=1S/C23H25BrO4/c1-22(2)8-14(25)20(15(26)9-22)19-13-6-5-12(24)7-17(13)28-18-11-23(3,4)10-16(27)21(18)19/h5-7,19-20H,8-11H2,1-4H3
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36n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in thymidine kinase deficient human LM cells


J Med Chem 51: 4765-70 (2008)


Article DOI: 10.1021/jm8003587
BindingDB Entry DOI: 10.7270/Q2J96664
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50261899
PNG
(9-(2-Hydroxy-4,4-dimethyl-6-oxocyclohexyl)-3,3,6-t...)
Show SMILES Cc1ccc2C(C3C(=O)CC(C)(C)CC3=O)C3=C(CC(C)(C)CC3=O)Oc2c1 |t:17|
Show InChI InChI=1S/C24H28O4/c1-13-6-7-14-18(8-13)28-19-12-24(4,5)11-17(27)22(19)20(14)21-15(25)9-23(2,3)10-16(21)26/h6-8,20-21H,9-12H2,1-5H3
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36n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in thymidine kinase deficient human LM cells


J Med Chem 51: 4765-70 (2008)


Article DOI: 10.1021/jm8003587
BindingDB Entry DOI: 10.7270/Q2J96664
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50261900
PNG
(6-Ethyl-9-(2-hydroxy-4,4-dimethyl-6-oxocyclohexyl)...)
Show SMILES CCc1ccc2C(C3C(=O)CC(C)(C)CC3=O)C3=C(CC(C)(C)CC3=O)Oc2c1 |t:18|
Show InChI InChI=1S/C25H30O4/c1-6-14-7-8-15-19(9-14)29-20-13-25(4,5)12-18(28)23(20)21(15)22-16(26)10-24(2,3)11-17(22)27/h7-9,21-22H,6,10-13H2,1-5H3
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41n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in thymidine kinase deficient human LM cells


J Med Chem 51: 4765-70 (2008)


Article DOI: 10.1021/jm8003587
BindingDB Entry DOI: 10.7270/Q2J96664
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50123717
PNG
(CHEMBL435036 | Indan-2-carboxylic acid [5-(4-chlor...)
Show SMILES Clc1ccc(cc1)-c1cc(NC(=O)C2Cc3ccccc3C2)[nH]n1
Show InChI InChI=1S/C19H16ClN3O/c20-16-7-5-12(6-8-16)17-11-18(23-22-17)21-19(24)15-9-13-3-1-2-4-14(13)10-15/h1-8,11,15H,9-10H2,(H2,21,22,23,24)
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59n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]-PYY binding to human recombinant Neuropeptide Y receptor type 5 in LMtk-cells


J Med Chem 46: 666-9 (2003)


Article DOI: 10.1021/jm025513q
BindingDB Entry DOI: 10.7270/Q2028QWP
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50123726
PNG
(CHEMBL159070 | Indan-2-carboxylic acid [5-(4-metho...)
Show SMILES COc1ccc(cc1)-c1cc(NC(=O)C2Cc3ccccc3C2)[nH]n1
Show InChI InChI=1S/C20H19N3O2/c1-25-17-8-6-13(7-9-17)18-12-19(23-22-18)21-20(24)16-10-14-4-2-3-5-15(14)11-16/h2-9,12,16H,10-11H2,1H3,(H2,21,22,23,24)
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62n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]-PYY binding to human recombinant Neuropeptide Y receptor type 5 in LMtk-cells


J Med Chem 46: 666-9 (2003)


Article DOI: 10.1021/jm025513q
BindingDB Entry DOI: 10.7270/Q2028QWP
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50261725
PNG
(5-Chloro-9-(2-hydroxy-4,4-dimethyl-6-oxocyclohexyl...)
Show SMILES CC1(C)CC(=O)C(C2C3=C(CC(C)(C)CC3=O)Oc3c(Cl)cccc23)C(=O)C1 |t:8|
Show InChI InChI=1S/C23H25ClO4/c1-22(2)8-14(25)19(15(26)9-22)18-12-6-5-7-13(24)21(12)28-17-11-23(3,4)10-16(27)20(17)18/h5-7,18-19H,8-11H2,1-4H3
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71n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in thymidine kinase deficient human LM cells


J Med Chem 51: 4765-70 (2008)


Article DOI: 10.1021/jm8003587
BindingDB Entry DOI: 10.7270/Q2J96664
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50123727
PNG
(CHEMBL158759 | Indan-2-carboxylic acid (5-p-tolyl-...)
Show SMILES Cc1ccc(cc1)-c1cc(NC(=O)C2Cc3ccccc3C2)[nH]n1
Show InChI InChI=1S/C20H19N3O/c1-13-6-8-14(9-7-13)18-12-19(23-22-18)21-20(24)17-10-15-4-2-3-5-16(15)11-17/h2-9,12,17H,10-11H2,1H3,(H2,21,22,23,24)
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80n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]-PYY binding to human recombinant Neuropeptide Y receptor type 5 in LMtk-cells


J Med Chem 46: 666-9 (2003)


Article DOI: 10.1021/jm025513q
BindingDB Entry DOI: 10.7270/Q2028QWP
More data for this
Ligand-Target Pair
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