Compile Data Set for Download or QSAR

Found 3598 hits of ec50 for UniProtKB: Q07869   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50349809 (CHEMBL1813006) Show SMILES CCO[C@@H](Cc1ccc(OCc2nc(oc2C)-c2ccc(C)s2)cc1)C(O)=O |r| Show InChI InChI=1S/C21H23NO5S/c1-4-25-18(21(23)24)11-15-6-8-16(9-7-15)26-12-17-14(3)27-20(22-17)19-10-5-13(2)28-19/h5-10,18H,4,11-12H2,1-3H3,(H,23,24)/t18-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.0000500	n/a	n/a	n/a	n/a
Zydus Research Centre Curated by ChEMBL					Assay Description Transactivation of human PPARalpha expressed in human HepG2 cells cotransfected with PPRE3-TK-Luc by luciferase reporter gene assay				Bioorg Med Chem Lett 21: 3103-9 (2011) Article DOI: 10.1016/j.bmcl.2011.03.020 BindingDB Entry DOI: 10.7270/Q2ZC837H
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50349808 (CHEMBL1813005) Show SMILES CCO[C@@H](Cc1ccc(OCc2nc(oc2C)-c2sccc2C)cc1)C(O)=O |r| Show InChI InChI=1S/C21H23NO5S/c1-4-25-18(21(23)24)11-15-5-7-16(8-6-15)26-12-17-14(3)27-20(22-17)19-13(2)9-10-28-19/h5-10,18H,4,11-12H2,1-3H3,(H,23,24)/t18-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.0000600	n/a	n/a	n/a	n/a
Zydus Research Centre Curated by ChEMBL					Assay Description Transactivation of human PPARalpha expressed in human HepG2 cells cotransfected with PPRE3-TK-Luc by luciferase reporter gene assay				Bioorg Med Chem Lett 21: 3103-9 (2011) Article DOI: 10.1016/j.bmcl.2011.03.020 BindingDB Entry DOI: 10.7270/Q2ZC837H
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50349812 (CHEMBL1813010) Show SMILES CCO[C@@H](Cc1ccc(OCCc2nc(oc2C)-c2sccc2C)cc1)C(O)=O |r| Show InChI InChI=1S/C22H25NO5S/c1-4-26-19(22(24)25)13-16-5-7-17(8-6-16)27-11-9-18-15(3)28-21(23-18)20-14(2)10-12-29-20/h5-8,10,12,19H,4,9,11,13H2,1-3H3,(H,24,25)/t19-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.0000700	n/a	n/a	n/a	n/a
Zydus Research Centre Curated by ChEMBL					Assay Description Transactivation of human PPARalpha expressed in human HepG2 cells cotransfected with PPRE3-TK-Luc by luciferase reporter gene assay				Bioorg Med Chem Lett 21: 3103-9 (2011) Article DOI: 10.1016/j.bmcl.2011.03.020 BindingDB Entry DOI: 10.7270/Q2ZC837H
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50349813 (CHEMBL1813011) Show SMILES CCO[C@@H](Cc1ccc(OCCc2nc(oc2C)-c2ccc(C)s2)cc1)C(O)=O |r| Show InChI InChI=1S/C22H25NO5S/c1-4-26-19(22(24)25)13-16-6-8-17(9-7-16)27-12-11-18-15(3)28-21(23-18)20-10-5-14(2)29-20/h5-10,19H,4,11-13H2,1-3H3,(H,24,25)/t19-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.000310	n/a	n/a	n/a	n/a
Zydus Research Centre Curated by ChEMBL					Assay Description Transactivation of human PPARalpha expressed in human HepG2 cells cotransfected with PPRE3-TK-Luc by luciferase reporter gene assay				Bioorg Med Chem Lett 21: 3103-9 (2011) Article DOI: 10.1016/j.bmcl.2011.03.020 BindingDB Entry DOI: 10.7270/Q2ZC837H
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50256106 (4-(4-(5-methyl-2-p-tolyloxazol-4-yl)butoxyimino)-4...) Show SMILES Cc1oc(nc1CCCCO\N=C(/CCC(O)=O)c1ccccc1)-c1ccc(C)cc1 Show InChI InChI=1S/C25H28N2O4/c1-18-11-13-21(14-12-18)25-26-22(19(2)31-25)10-6-7-17-30-27-23(15-16-24(28)29)20-8-4-3-5-9-20/h3-5,8-9,11-14H,6-7,10,15-17H2,1-2H3,(H,28,29)/b27-23+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.00380	n/a	n/a	n/a	n/a
Zydus Research Centre Curated by ChEMBL					Assay Description Agonist activity at human PPARalpha transactivation expressed in human HePG2 cells				Bioorg Med Chem Lett 18: 6471-5 (2008) Article DOI: 10.1016/j.bmcl.2008.10.062 BindingDB Entry DOI: 10.7270/Q2BK1D9Z
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50349807 (CHEMBL1813003) Show SMILES CCO[C@@H](Cc1ccc(OCc2nc(oc2C)-c2cccs2)cc1)C(O)=O |r| Show InChI InChI=1S/C20H21NO5S/c1-3-24-17(20(22)23)11-14-6-8-15(9-7-14)25-12-16-13(2)26-19(21-16)18-5-4-10-27-18/h4-10,17H,3,11-12H2,1-2H3,(H,22,23)/t17-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	0.0260	n/a	n/a	n/a	n/a
Zydus Research Centre Curated by ChEMBL					Assay Description Transactivation of human PPARalpha expressed in human HepG2 cells cotransfected with PPRE3-TK-Luc by luciferase reporter gene assay				Bioorg Med Chem Lett 21: 3103-9 (2011) Article DOI: 10.1016/j.bmcl.2011.03.020 BindingDB Entry DOI: 10.7270/Q2ZC837H
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50261879 (2-Methyl-c-5-{4-[2-(5-methyl-2-(5-methylthiophen-2...) Show SMILES Cc1ccc(s1)-c1nc(CCOc2ccc(C[C@H]3CO[C@](C)(OC3)C(O)=O)cc2)c(C)o1 |r,wU:20.25,17.17,wD:20.21,(-9.95,-10.46,;-8.61,-11.22,;-7.21,-10.58,;-6.17,-11.72,;-6.93,-13.06,;-8.44,-12.75,;-6.29,-14.46,;-4.79,-14.77,;-4.61,-16.3,;-3.27,-17.06,;-1.94,-16.28,;-.6,-17.04,;.73,-16.26,;2.07,-17.02,;3.39,-16.24,;3.38,-14.7,;4.71,-13.92,;6.05,-14.68,;7.37,-13.89,;8.71,-14.65,;8.72,-16.19,;10.18,-15.74,;7.39,-16.97,;6.05,-16.21,;9.2,-17.65,;10.71,-17.96,;8.18,-18.8,;2.03,-13.94,;.71,-14.73,;-6.01,-16.93,;-6.32,-18.44,;-7.05,-15.8,)| Show InChI InChI=1S/C24H27NO6S/c1-15-4-9-21(32-15)22-25-20(16(2)31-22)10-11-28-19-7-5-17(6-8-19)12-18-13-29-24(3,23(26)27)30-14-18/h4-9,18H,10-14H2,1-3H3,(H,26,27)/t18-,24+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.0300	n/a	n/a	n/a	n/a
Zydus Research Centre Curated by ChEMBL					Assay Description Agonist activity at PPARalpha (unknown origin) expressed in human HepG2 cells assessed as induction of receptor transactivation by reporter gene assa...				Bioorg Med Chem 16: 7117-27 (2008) Article DOI: 10.1016/j.bmc.2008.06.050 BindingDB Entry DOI: 10.7270/Q2K93792
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50256109 ((2s,5s)-2-methyl-5-(4-((5-methyl-2-p-tolyloxazol-4...) Show SMILES Cc1oc(nc1COc1ccc(C[C@H]2CO[C@](C)(OC2)C(O)=O)cc1)-c1ccc(C)cc1 |r,wU:13.13,16.21,wD:16.17,(24.31,-36.45,;23.08,-35.51,;21.61,-35.96,;20.73,-34.69,;21.66,-33.46,;23.12,-33.97,;24.38,-33.1,;25.68,-33.93,;27.05,-33.22,;28.34,-34.06,;29.7,-33.35,;29.78,-31.81,;31.15,-31.11,;32.44,-31.94,;33.81,-31.22,;35.1,-32.06,;35.03,-33.6,;36.49,-34.04,;33.66,-34.3,;32.37,-33.47,;35.37,-35.09,;36.84,-35.55,;34.24,-36.14,;28.47,-30.98,;27.11,-31.69,;19.19,-34.65,;18.46,-33.3,;16.92,-33.27,;16.11,-34.58,;14.57,-34.55,;16.86,-35.94,;18.4,-35.97,)| Show InChI InChI=1S/C25H27NO6/c1-16-4-8-20(9-5-16)23-26-22(17(2)32-23)15-29-21-10-6-18(7-11-21)12-19-13-30-25(3,24(27)28)31-14-19/h4-11,19H,12-15H2,1-3H3,(H,27,28)/t19-,25+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.0720	n/a	n/a	n/a	n/a
Zydus Research Centre Curated by ChEMBL					Assay Description Agonist activity at PPARalpha (unknown origin) expressed in human HepG2 cells assessed as induction of receptor transactivation by reporter gene assa...				Bioorg Med Chem 16: 7117-27 (2008) Article DOI: 10.1016/j.bmc.2008.06.050 BindingDB Entry DOI: 10.7270/Q2K93792
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50261703 (2-Methyl-c-5-{4-[2-(5-methyl-2-(4-methylphenyl)oxa...) Show SMILES Cc1oc(nc1CCOc1ccc(C[C@H]2CO[C@](C)(OC2)C(O)=O)cc1)-c1ccc(C)cc1 |r,wU:17.22,14.14,wD:17.18,(19.1,-51.29,;19.48,-49.8,;18.49,-48.61,;19.32,-47.31,;20.81,-47.69,;20.92,-49.23,;22.22,-50.05,;23.58,-49.34,;24.88,-50.16,;26.25,-49.45,;27.54,-50.28,;28.91,-49.56,;28.97,-48.02,;30.33,-47.3,;31.64,-48.13,;32.99,-47.4,;34.29,-48.23,;34.23,-49.77,;35.71,-49.39,;32.86,-50.48,;31.57,-49.66,;34.64,-51.25,;36.14,-51.63,;33.57,-52.35,;27.66,-47.2,;26.3,-47.92,;18.75,-45.88,;19.71,-44.68,;19.14,-43.25,;17.62,-43.02,;17.05,-41.59,;16.66,-44.24,;17.23,-45.67,)| Show InChI InChI=1S/C26H29NO6/c1-17-4-8-21(9-5-17)24-27-23(18(2)33-24)12-13-30-22-10-6-19(7-11-22)14-20-15-31-26(3,25(28)29)32-16-20/h4-11,20H,12-16H2,1-3H3,(H,28,29)/t20-,26+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.0890	n/a	n/a	n/a	n/a
Zydus Research Centre Curated by ChEMBL					Assay Description Agonist activity at PPARalpha (unknown origin) expressed in human HepG2 cells assessed as induction of receptor transactivation by reporter gene assa...				Bioorg Med Chem 16: 7117-27 (2008) Article DOI: 10.1016/j.bmc.2008.06.050 BindingDB Entry DOI: 10.7270/Q2K93792
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50349811 (CHEMBL1813008) Show SMILES CCO[C@@H](Cc1ccc(OCCc2nc(oc2C)-c2cccs2)cc1)C(O)=O |r| Show InChI InChI=1S/C21H23NO5S/c1-3-25-18(21(23)24)13-15-6-8-16(9-7-15)26-11-10-17-14(2)27-20(22-17)19-5-4-12-28-19/h4-9,12,18H,3,10-11,13H2,1-2H3,(H,23,24)/t18-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.100	n/a	n/a	n/a	n/a
Zydus Research Centre Curated by ChEMBL					Assay Description Transactivation of human PPARalpha expressed in human HepG2 cells cotransfected with PPRE3-TK-Luc by luciferase reporter gene assay				Bioorg Med Chem Lett 21: 3103-9 (2011) Article DOI: 10.1016/j.bmcl.2011.03.020 BindingDB Entry DOI: 10.7270/Q2ZC837H
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50041007 (CHEMBL3354987) Show SMILES Cc1c(cccc1-c1ccc(\C=C2\SC(=O)N(CC(=O)Nc3ccc(F)cc3)C2=O)o1)C(O)=O Show InChI InChI=1S/C24H17FN2O6S/c1-13-17(3-2-4-18(13)23(30)31)19-10-9-16(33-19)11-20-22(29)27(24(32)34-20)12-21(28)26-15-7-5-14(25)6-8-15/h2-11H,12H2,1H3,(H,26,28)(H,30,31)/b20-11+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.160	n/a	n/a	n/a	n/a
National Institute of Pharmaceutical Education and Research (NIPER) Curated by ChEMBL					Assay Description Agonist activity at GAL4-tagged PPARalpha ligand-binding domain (unknown origin) expressed in HEK293T cells incubated for 16 to 19 hrs by beta-lactam...				Bioorg Med Chem Lett 25: 270-5 (2014) Article DOI: 10.1016/j.bmcl.2014.11.052 BindingDB Entry DOI: 10.7270/Q2S18434
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50261702 (2-Methyl-c-5-[4-{2-(5-methyl-2-phenyloxazol-4-yl)e...) Show SMILES Cc1oc(nc1CCOc1ccc(C[C@H]2CO[C@](C)(OC2)C(O)=O)cc1)-c1ccccc1 |r,wU:17.22,14.14,wD:17.18,(-6.59,-51.43,;-6.28,-49.93,;-7.32,-48.79,;-6.56,-47.45,;-5.05,-47.76,;-4.87,-49.29,;-3.53,-50.05,;-2.2,-49.27,;-.86,-50.03,;.46,-49.25,;1.8,-50.01,;3.13,-49.24,;3.12,-47.69,;4.44,-46.91,;5.78,-47.67,;7.1,-46.88,;8.44,-47.65,;8.45,-49.19,;9.91,-48.74,;7.12,-49.96,;5.79,-49.2,;8.94,-50.65,;10.45,-50.96,;7.92,-51.8,;1.77,-46.93,;.45,-47.72,;-7.2,-46.05,;-6.29,-44.8,;-6.93,-43.4,;-8.47,-43.25,;-9.36,-44.51,;-8.72,-45.91,)| Show InChI InChI=1S/C25H27NO6/c1-17-22(26-23(32-17)20-6-4-3-5-7-20)12-13-29-21-10-8-18(9-11-21)14-19-15-30-25(2,24(27)28)31-16-19/h3-11,19H,12-16H2,1-2H3,(H,27,28)/t19-,25+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.272	n/a	n/a	n/a	n/a
Zydus Research Centre Curated by ChEMBL					Assay Description Agonist activity at PPARalpha (unknown origin) expressed in human HepG2 cells assessed as induction of receptor transactivation by reporter gene assa...				Bioorg Med Chem 16: 7117-27 (2008) Article DOI: 10.1016/j.bmc.2008.06.050 BindingDB Entry DOI: 10.7270/Q2K93792
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50229206 (CHEMBL253310 | N-(4-(trifluoromethylsulfonamido)be...) Show SMILES Cc1nc(sc1C(=O)NCc1ccc(NS(=O)(=O)C(F)(F)F)cc1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C20H15F6N3O3S2/c1-11-16(33-18(28-11)13-4-6-14(7-5-13)19(21,22)23)17(30)27-10-12-2-8-15(9-3-12)29-34(31,32)20(24,25)26/h2-9,29H,10H2,1H3,(H,27,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a
Centre de Recherches Curated by ChEMBL					Assay Description Agonist activity at human PPARalpha assessed as receptor activation by cell based assay				Bioorg Med Chem Lett 18: 710-5 (2008) Article DOI: 10.1016/j.bmcl.2007.11.053 BindingDB Entry DOI: 10.7270/Q2542NBN
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50261878 (2-Methyl-c-5-{4-[5-methyl-2-(5-methylthiophen-2-yl...) Show SMILES Cc1ccc(s1)-c1nc(COc2ccc(C[C@H]3CO[C@](C)(OC3)C(O)=O)cc2)c(C)o1 |r,wU:16.16,19.24,wD:19.20,(16.23,-2.7,;17.45,-1.75,;17.4,-.22,;18.85,.31,;19.79,-.9,;18.92,-2.18,;21.33,-.86,;22.2,.42,;23.68,-.01,;25.03,.73,;26.34,-.07,;27.7,.67,;29.01,-.14,;30.36,.59,;30.4,2.13,;31.75,2.87,;33.06,2.07,;34.41,2.82,;35.72,2.01,;35.68,.47,;37.16,.87,;34.33,-.26,;33.02,.54,;36.12,-1,;37.62,-1.36,;35.06,-2.12,;29.07,2.94,;27.73,2.2,;23.72,-1.55,;25,-2.42,;22.28,-2.07,)| Show InChI InChI=1S/C23H25NO6S/c1-14-4-9-20(31-14)21-24-19(15(2)30-21)13-27-18-7-5-16(6-8-18)10-17-11-28-23(3,22(25)26)29-12-17/h4-9,17H,10-13H2,1-3H3,(H,25,26)/t17-,23+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.600	n/a	n/a	n/a	n/a
Zydus Research Centre Curated by ChEMBL					Assay Description Agonist activity at PPARalpha (unknown origin) expressed in human HepG2 cells assessed as induction of receptor transactivation by reporter gene assa...				Bioorg Med Chem 16: 7117-27 (2008) Article DOI: 10.1016/j.bmc.2008.06.050 BindingDB Entry DOI: 10.7270/Q2K93792
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50099491 (2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...) Show SMILES CC(C)(Sc1ccc(CCN(CCCCC2CCCCC2)C(=O)NC2CCCCC2)cc1)C(O)=O Show InChI InChI=1S/C29H46N2O3S/c1-29(2,27(32)33)35-26-18-16-24(17-19-26)20-22-31(28(34)30-25-14-7-4-8-15-25)21-10-9-13-23-11-5-3-6-12-23/h16-19,23,25H,3-15,20-22H2,1-2H3,(H,30,34)(H,32,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	0.600	n/a	n/a	n/a	n/a
University of Innsbruck Curated by ChEMBL					Assay Description Activation of PPARalpha transfected in HEK293 cells after 18 hrs by firefly luciferase reporter gene-based luminescence assay relative to control				J Nat Prod 74: 1779-86 (2011) Article DOI: 10.1021/np200343t BindingDB Entry DOI: 10.7270/Q26974ND
					More data for this Ligand-Target Pair				3D Structure (crystal)
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50132472 ((S)-2-{3-[4-(4-Fluoro-phenoxy)-benzylcarbamoyl]-4-...) Show SMILES CC[C@@H](Cc1ccc(OC)c(c1)C(=O)NCc1ccc(Oc2ccc(F)cc2)cc1)C(O)=O Show InChI InChI=1S/C26H26FNO5/c1-3-19(26(30)31)14-18-6-13-24(32-2)23(15-18)25(29)28-16-17-4-9-21(10-5-17)33-22-11-7-20(27)8-12-22/h4-13,15,19H,3,14,16H2,1-2H3,(H,28,29)(H,30,31)/t19-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	0.615	n/a	n/a	n/a	n/a
Kyorin Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Transcriptional activation activity on human T279M-mutant Peroxisome proliferator activated receptor alpha expressed in CHO-K1 cells				Bioorg Med Chem Lett 13: 3145-9 (2003) BindingDB Entry DOI: 10.7270/Q20K280J
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50615692 (SAROGLITAZAR | Saroglitazar) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PDB UniChem	PDB	n/a	n/a	n/a	n/a	0.650	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair				3D Structure (crystal)
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50568096 (CHEMBL4866115) Show SMILES Cc1ccc(Cn2nc(CCCc3ccc(OC(C)(C)C(O)=O)cc3)n(Cc3ccc(C)cc3)c2=O)cc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.850	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at Gal4-fused human PPARalpha co-expressed with RXRalpha in monkey CV1 cells assessed as PPRE transcriptional activation incubated f...				Citation and Details Article DOI: 10.1016/j.bmc.2021.116193 BindingDB Entry DOI: 10.7270/Q2N01B8M
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50568100 (CHEMBL4861761) Show SMILES COc1ccc(Cn2c(CCCc3ccc(OC(C)(C)C(O)=O)cc3)nn(Cc3ccc(C)cc3)c2=O)cc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.870	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at Gal4-fused human PPARalpha co-expressed with RXRalpha in monkey CV1 cells assessed as PPRE transcriptional activation incubated f...				Citation and Details Article DOI: 10.1016/j.bmc.2021.116193 BindingDB Entry DOI: 10.7270/Q2N01B8M
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50099491 (2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...) Show SMILES CC(C)(Sc1ccc(CCN(CCCCC2CCCCC2)C(=O)NC2CCCCC2)cc1)C(O)=O Show InChI InChI=1S/C29H46N2O3S/c1-29(2,27(32)33)35-26-18-16-24(17-19-26)20-22-31(28(34)30-25-14-7-4-8-15-25)21-10-9-13-23-11-5-3-6-12-23/h16-19,23,25H,3-15,20-22H2,1-2H3,(H,30,34)(H,32,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	0.890	n/a	n/a	n/a	n/a
Phenex Pharmaceuticals AG Curated by ChEMBL					Assay Description Agonist activity at human PPARalpha expressed in HEK293 cells by luciferase reporter gene assay				Bioorg Med Chem Lett 24: 5265-7 (2014) Article DOI: 10.1016/j.bmcl.2014.09.053 BindingDB Entry DOI: 10.7270/Q2S46TKZ
					More data for this Ligand-Target Pair				3D Structure (crystal)
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50568097 (CHEMBL4879102) Show SMILES Cc1ccc(Cn2nc(CCCc3ccc(OC(C)(C)C(O)=O)cc3)n(Cc3ccc(F)cc3)c2=O)cc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.950	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at Gal4-fused human PPARalpha co-expressed with RXRalpha in monkey CV1 cells assessed as PPRE transcriptional activation incubated f...				Citation and Details Article DOI: 10.1016/j.bmc.2021.116193 BindingDB Entry DOI: 10.7270/Q2N01B8M
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50099491 (2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...) Show SMILES CC(C)(Sc1ccc(CCN(CCCCC2CCCCC2)C(=O)NC2CCCCC2)cc1)C(O)=O Show InChI InChI=1S/C29H46N2O3S/c1-29(2,27(32)33)35-26-18-16-24(17-19-26)20-22-31(28(34)30-25-14-7-4-8-15-25)21-10-9-13-23-11-5-3-6-12-23/h16-19,23,25H,3-15,20-22H2,1-2H3,(H,30,34)(H,32,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00641 BindingDB Entry DOI: 10.7270/Q2K35ZR8
					More data for this Ligand-Target Pair				3D Structure (crystal)
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50214899 ((R)-2-(3-((benzo[d]oxazol-2-yl(3-(4-methoxyphenoxy...) Show SMILES CC[C@@H](Oc1cccc(CN(CCCOc2ccc(OC)cc2)c2nc3ccccc3o2)c1)C(O)=O Show InChI InChI=1S/C28H30N2O6/c1-3-25(27(31)32)35-23-9-6-8-20(18-23)19-30(28-29-24-10-4-5-11-26(24)36-28)16-7-17-34-22-14-12-21(33-2)13-15-22/h4-6,8-15,18,25H,3,7,16-17,19H2,1-2H3,(H,31,32)/t25-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair				3D Structure (crystal)
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50099494 (2-(4-{2-[1-(4-Cyclohexyl-butyl)-3-(3,5-dichloro-ph...) Show SMILES CC(C)(Sc1ccc(CCN(CCCCC2CCCCC2)C(=O)Nc2cc(Cl)cc(Cl)c2)cc1)C(O)=O Show InChI InChI=1S/C29H38Cl2N2O3S/c1-29(2,27(34)35)37-26-13-11-22(12-14-26)15-17-33(16-7-6-10-21-8-4-3-5-9-21)28(36)32-25-19-23(30)18-24(31)20-25/h11-14,18-21H,3-10,15-17H2,1-2H3,(H,32,36)(H,34,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description In vitro transcriptional activation in CV-1 cells expressing human Gal4-PPAR alpha ligand binding domain				Bioorg Med Chem Lett 11: 1225-7 (2001) BindingDB Entry DOI: 10.7270/Q2Z31XX0
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50004755 (CHEMBL2237300) Show SMILES Cc1oc(nc1CCOc1ccc(C[C@H](Oc2ccccc2)C(O)=O)cc1)C1CCCCC1 |r| Show InChI InChI=1S/C27H31NO5/c1-19-24(28-26(32-19)21-8-4-2-5-9-21)16-17-31-22-14-12-20(13-15-22)18-25(27(29)30)33-23-10-6-3-7-11-23/h3,6-7,10-15,21,25H,2,4-5,8-9,16-18H2,1H3,(H,29,30)/t25-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
TBA					Assay Description Transactivation of GAL4-fused Homo sapiens (human) PPARalpha DNA binding domain expressed in African green monkey CV1 cells by luciferase reporter ge...				Citation and Details Article DOI: 10.1007/s00044-012-0003-4 BindingDB Entry DOI: 10.7270/Q280544F
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50004755 (CHEMBL2237300) Show SMILES Cc1oc(nc1CCOc1ccc(C[C@H](Oc2ccccc2)C(O)=O)cc1)C1CCCCC1 |r| Show InChI InChI=1S/C27H31NO5/c1-19-24(28-26(32-19)21-8-4-2-5-9-21)16-17-31-22-14-12-20(13-15-22)18-25(27(29)30)33-23-10-6-3-7-11-23/h3,6-7,10-15,21,25H,2,4-5,8-9,16-18H2,1H3,(H,29,30)/t25-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
TBA					Assay Description Transactivation of GAL4-fused Homo sapiens (human) PPARalpha DNA binding domain expressed in African green monkey CV1 cells by luciferase reporter ge...				Citation and Details Article DOI: 10.1007/s00044-012-0003-4 BindingDB Entry DOI: 10.7270/Q280544F
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50063089 (CHEMBL3398443) Show SMILES Cc1oc(nc1CCOc1ccc(C[C@@H]2CN(C[C@@H]2C(O)=O)C(=O)Oc2ccccc2)cc1)-c1ccccc1 |r| Show InChI InChI=1S/C31H30N2O6/c1-21-28(32-29(38-21)23-8-4-2-5-9-23)16-17-37-25-14-12-22(13-15-25)18-24-19-33(20-27(24)30(34)35)31(36)39-26-10-6-3-7-11-26/h2-15,24,27H,16-20H2,1H3,(H,34,35)/t24-,27+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research and Development (R&D) Curated by ChEMBL					Assay Description Agonist activity at GAL4 tagged human PPARalpha ligand binding domain expressed in HEK293 cells by luciferase reporter gene assay				Bioorg Med Chem Lett 25: 1196-205 (2015) Article DOI: 10.1016/j.bmcl.2015.01.066 BindingDB Entry DOI: 10.7270/Q20866ZP
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50063089 (CHEMBL3398443) Show SMILES Cc1oc(nc1CCOc1ccc(C[C@@H]2CN(C[C@@H]2C(O)=O)C(=O)Oc2ccccc2)cc1)-c1ccccc1 |r| Show InChI InChI=1S/C31H30N2O6/c1-21-28(32-29(38-21)23-8-4-2-5-9-23)16-17-37-25-14-12-22(13-15-25)18-24-19-33(20-27(24)30(34)35)31(36)39-26-10-6-3-7-11-26/h2-15,24,27H,16-20H2,1H3,(H,34,35)/t24-,27+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research and Development (R&D) Curated by ChEMBL					Assay Description Agonist activity at GAL4 tagged human PPARalpha ligand binding domain expressed in HEK293 cells by luciferase reporter gene assay				Bioorg Med Chem Lett 25: 1196-205 (2015) Article DOI: 10.1016/j.bmcl.2015.01.066 BindingDB Entry DOI: 10.7270/Q20866ZP
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50145719 ((S)-3-{4-[2-(2-Cyclohexyl-5-methyl-oxazol-4-yl)-et...) Show SMILES Cc1oc(nc1CCOc1ccc(C[C@](C)(Oc2ccccc2)C(O)=O)cc1)C1CCCCC1 Show InChI InChI=1S/C28H33NO5/c1-20-25(29-26(33-20)22-9-5-3-6-10-22)17-18-32-23-15-13-21(14-16-23)19-28(2,27(30)31)34-24-11-7-4-8-12-24/h4,7-8,11-16,22H,3,5-6,9-10,17-19H2,1-2H3,(H,30,31)/t28-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Transcriptional activation of reporter assay by human Peroxisome proliferator activated receptor alpha in CV-1 cells				J Med Chem 47: 2422-5 (2004) Article DOI: 10.1021/jm0342616 BindingDB Entry DOI: 10.7270/Q2TQ6100
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50214899 ((R)-2-(3-((benzo[d]oxazol-2-yl(3-(4-methoxyphenoxy...) Show SMILES CC[C@@H](Oc1cccc(CN(CCCOc2ccc(OC)cc2)c2nc3ccccc3o2)c1)C(O)=O Show InChI InChI=1S/C28H30N2O6/c1-3-25(27(31)32)35-23-9-6-8-20(18-23)19-30(28-29-24-10-4-5-11-26(24)36-28)16-7-17-34-22-14-12-21(33-2)13-15-22/h4-6,8-15,18,25H,3,7,16-17,19H2,1-2H3,(H,31,32)/t25-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
National Institute of Pharmaceutical Education and Research (NIPER) Curated by ChEMBL					Assay Description Agonist activity at GAL4-tagged PPARalpha ligand-binding domain (unknown origin) expressed in HEK293T cells incubated for 16 to 19 hrs by beta-lactam...				Bioorg Med Chem Lett 25: 270-5 (2014) Article DOI: 10.1016/j.bmcl.2014.11.052 BindingDB Entry DOI: 10.7270/Q2S18434
					More data for this Ligand-Target Pair				3D Structure (crystal)
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50179830 ((S)-2-(4-(3-(2-chloro-4-cyclohexylphenoxy)propoxy)...) Show SMILES CC[C@@](C)(Cc1ccc(OCCCOc2ccc(cc2Cl)C2CCCCC2)cc1)C(O)=O Show InChI InChI=1S/C27H35ClO4/c1-3-27(2,26(29)30)19-20-10-13-23(14-11-20)31-16-7-17-32-25-15-12-22(18-24(25)28)21-8-5-4-6-9-21/h10-15,18,21H,3-9,16-17,19H2,1-2H3,(H,29,30)/t27-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Transactivation by human PPAR alpha in COS1 cells				Bioorg Med Chem Lett 16: 1673-8 (2006) Article DOI: 10.1016/j.bmcl.2005.12.022 BindingDB Entry DOI: 10.7270/Q2930SRT
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50004755 (CHEMBL2237300) Show SMILES Cc1oc(nc1CCOc1ccc(C[C@H](Oc2ccccc2)C(O)=O)cc1)C1CCCCC1 |r| Show InChI InChI=1S/C27H31NO5/c1-19-24(28-26(32-19)21-8-4-2-5-9-21)16-17-31-22-14-12-20(13-15-22)18-25(27(29)30)33-23-10-6-3-7-11-23/h3,6-7,10-15,21,25H,2,4-5,8-9,16-18H2,1H3,(H,29,30)/t25-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
TBA					Assay Description Transactivation of Homo sapiens (human) PPARalpha assessed as luciferase activity by reporter gene assay				Citation and Details Article DOI: 10.1007/s00044-011-9818-7 BindingDB Entry DOI: 10.7270/Q2R49TNP
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50568099 (CHEMBL4855604) Show SMILES COc1cccc(Cn2c(CCCc3ccc(OC(C)(C)C(O)=O)cc3)nn(Cc3ccc(C)cc3)c2=O)c1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at Gal4-fused human PPARalpha co-expressed with RXRalpha in monkey CV1 cells assessed as PPRE transcriptional activation incubated f...				Citation and Details Article DOI: 10.1016/j.bmc.2021.116193 BindingDB Entry DOI: 10.7270/Q2N01B8M
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50568102 (CHEMBL4847453) Show SMILES Cc1ccc(Cn2nc(CCCc3ccc(OC(C)(C)C(O)=O)cc3)n(Cc3ccc(Cl)cc3)c2=O)cc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at Gal4-fused human PPARalpha co-expressed with RXRalpha in monkey CV1 cells assessed as PPRE transcriptional activation incubated f...				Citation and Details Article DOI: 10.1016/j.bmc.2021.116193 BindingDB Entry DOI: 10.7270/Q2N01B8M
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50256108 (4-(6-(5-methyl-2-p-tolyloxazol-4-yl)hexyloxyimino)...) Show SMILES Cc1oc(nc1CCCCCCO\N=C(\CCC(O)=O)c1ccccc1)-c1ccc(C)cc1 Show InChI InChI=1S/C27H32N2O4/c1-20-13-15-23(16-14-20)27-28-24(21(2)33-27)12-8-3-4-9-19-32-29-25(17-18-26(30)31)22-10-6-5-7-11-22/h5-7,10-11,13-16H,3-4,8-9,12,17-19H2,1-2H3,(H,30,31)/b29-25-	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
Zydus Research Centre Curated by ChEMBL					Assay Description Agonist activity at human PPARalpha transactivation expressed in human HePG2 cells				Bioorg Med Chem Lett 18: 6471-5 (2008) Article DOI: 10.1016/j.bmcl.2008.10.062 BindingDB Entry DOI: 10.7270/Q2BK1D9Z
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50266550 (CHEMBL456912 | Methyl 7-(2-(5-methyl-2-p-tolyloxaz...) Show SMILES COC(=O)c1cc2ccc(OCCc3nc(oc3C)-c3ccc(C)cc3)cc2oc1=O Show InChI InChI=1S/C24H21NO6/c1-14-4-6-16(7-5-14)22-25-20(15(2)30-22)10-11-29-18-9-8-17-12-19(23(26)28-3)24(27)31-21(17)13-18/h4-9,12-13H,10-11H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
Graduate School of the Chinese Academy of Sciences Curated by ChEMBL					Assay Description Agonist activity at human PPARalpha in U2OS cells by transactivation assay				Eur J Med Chem 43: 2428-35 (2008) Article DOI: 10.1016/j.ejmech.2008.01.029 BindingDB Entry DOI: 10.7270/Q2R78F08
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50214893 (2-(3-((benzo[d]oxazol-2-yl(3-(p-tolyloxy)propyl)am...) Show SMILES CCC(Oc1cccc(CN(CCCOc2ccc(C)cc2)c2nc3ccccc3o2)c1)C(O)=O |w:2.1| Show InChI InChI=1S/C28H30N2O5/c1-3-25(27(31)32)34-23-9-6-8-21(18-23)19-30(28-29-24-10-4-5-11-26(24)35-28)16-7-17-33-22-14-12-20(2)13-15-22/h4-6,8-15,18,25H,3,7,16-17,19H2,1-2H3,(H,31,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
Kowa Co. Curated by ChEMBL					Assay Description Agonist activity at human recombinant PPARalpha by GAL4 transactivation assay				Bioorg Med Chem Lett 17: 4689-93 (2007) Article DOI: 10.1016/j.bmcl.2007.05.066 BindingDB Entry DOI: 10.7270/Q2J67GM5
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50214899 ((R)-2-(3-((benzo[d]oxazol-2-yl(3-(4-methoxyphenoxy...) Show SMILES CC[C@@H](Oc1cccc(CN(CCCOc2ccc(OC)cc2)c2nc3ccccc3o2)c1)C(O)=O Show InChI InChI=1S/C28H30N2O6/c1-3-25(27(31)32)35-23-9-6-8-20(18-23)19-30(28-29-24-10-4-5-11-26(24)36-28)16-7-17-34-22-14-12-21(33-2)13-15-22/h4-6,8-15,18,25H,3,7,16-17,19H2,1-2H3,(H,31,32)/t25-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
Kowa Co. Curated by ChEMBL					Assay Description Agonist activity at human recombinant PPARalpha by GAL4 transactivation assay				Bioorg Med Chem Lett 17: 4689-93 (2007) Article DOI: 10.1016/j.bmcl.2007.05.066 BindingDB Entry DOI: 10.7270/Q2J67GM5
					More data for this Ligand-Target Pair				3D Structure (crystal)
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50214906 (2-(3-((benzo[d]oxazol-2-yl(3-(4-methoxyphenoxy)pro...) Show SMILES CCC(Oc1cccc(CN(CCCOc2ccc(OC)cc2)c2nc3ccccc3o2)c1)C(O)=O |w:2.1| Show InChI InChI=1S/C28H30N2O6/c1-3-25(27(31)32)35-23-9-6-8-20(18-23)19-30(28-29-24-10-4-5-11-26(24)36-28)16-7-17-34-22-14-12-21(33-2)13-15-22/h4-6,8-15,18,25H,3,7,16-17,19H2,1-2H3,(H,31,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
Kowa Co. Curated by ChEMBL					Assay Description Agonist activity at human recombinant PPARalpha by GAL4 transactivation assay				Bioorg Med Chem Lett 17: 4689-93 (2007) Article DOI: 10.1016/j.bmcl.2007.05.066 BindingDB Entry DOI: 10.7270/Q2J67GM5
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50214914 (2-(3-((benzo[d]oxazol-2-yl(3-(2,4-dimethylphenoxy)...) Show SMILES CCC(Oc1cccc(CN(CCCOc2ccc(C)cc2C)c2nc3ccccc3o2)c1)C(O)=O |w:2.1| Show InChI InChI=1S/C29H32N2O5/c1-4-25(28(32)33)35-23-10-7-9-22(18-23)19-31(29-30-24-11-5-6-12-27(24)36-29)15-8-16-34-26-14-13-20(2)17-21(26)3/h5-7,9-14,17-18,25H,4,8,15-16,19H2,1-3H3,(H,32,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
Kowa Co. Curated by ChEMBL					Assay Description Agonist activity at human recombinant PPARalpha by GAL4 transactivation assay				Bioorg Med Chem Lett 17: 4689-93 (2007) Article DOI: 10.1016/j.bmcl.2007.05.066 BindingDB Entry DOI: 10.7270/Q2J67GM5
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50214891 (2-(3-((benzo[d]oxazol-2-yl(3-(3,4-dimethylphenoxy)...) Show SMILES CCC(Oc1cccc(CN(CCCOc2ccc(C)c(C)c2)c2nc3ccccc3o2)c1)C(O)=O |w:2.1| Show InChI InChI=1S/C29H32N2O5/c1-4-26(28(32)33)35-24-10-7-9-22(18-24)19-31(29-30-25-11-5-6-12-27(25)36-29)15-8-16-34-23-14-13-20(2)21(3)17-23/h5-7,9-14,17-18,26H,4,8,15-16,19H2,1-3H3,(H,32,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
Kowa Co. Curated by ChEMBL					Assay Description Agonist activity at human recombinant PPARalpha by GAL4 transactivation assay				Bioorg Med Chem Lett 17: 4689-93 (2007) Article DOI: 10.1016/j.bmcl.2007.05.066 BindingDB Entry DOI: 10.7270/Q2J67GM5
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50261701 (2-Methyl-c-5-[4-(5-methyl-2-phenyloxazol-4-ylmetho...) Show SMILES Cc1oc(nc1COc1ccc(C[C@H]2CO[C@](C)(OC2)C(O)=O)cc1)-c1ccccc1 |r,wU:13.13,16.21,wD:16.17,(-1.08,-34.97,;-2.35,-34.1,;-3.8,-34.62,;-4.75,-33.41,;-3.88,-32.13,;-2.4,-32.56,;-1.05,-31.82,;.27,-32.62,;1.62,-31.89,;2.93,-32.69,;4.28,-31.96,;4.32,-30.42,;5.67,-29.68,;6.99,-30.48,;8.33,-29.73,;9.65,-30.54,;9.61,-32.08,;11.08,-31.68,;8.25,-32.81,;6.94,-32.01,;10.05,-33.56,;11.54,-33.91,;8.99,-34.67,;3,-29.61,;1.65,-30.35,;-6.29,-33.46,;-7.09,-32.14,;-8.63,-32.19,;-9.36,-33.55,;-8.54,-34.86,;-7,-34.81,)| Show InChI InChI=1S/C24H25NO6/c1-16-21(25-22(31-16)19-6-4-3-5-7-19)15-28-20-10-8-17(9-11-20)12-18-13-29-24(2,23(26)27)30-14-18/h3-11,18H,12-15H2,1-2H3,(H,26,27)/t18-,24+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.09	n/a	n/a	n/a	n/a
Zydus Research Centre Curated by ChEMBL					Assay Description Agonist activity at PPARalpha (unknown origin) expressed in human HepG2 cells assessed as induction of receptor transactivation by reporter gene assa...				Bioorg Med Chem 16: 7117-27 (2008) Article DOI: 10.1016/j.bmc.2008.06.050 BindingDB Entry DOI: 10.7270/Q2K93792
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM61633 (2-[[3-[(4-amoxycarbonylphenyl)carbamoyl]phenyl]car...) Show SMILES CCCCCOC(=O)c1ccc(NC(=O)c2cccc(NC(=O)c3ccccc3C(O)=O)c2)cc1 Show InChI InChI=1S/C27H26N2O6/c1-2-3-6-16-35-27(34)18-12-14-20(15-13-18)28-24(30)19-8-7-9-21(17-19)29-25(31)22-10-4-5-11-23(22)26(32)33/h4-5,7-15,17H,2-3,6,16H2,1H3,(H,28,30)(H,29,31)(H,32,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.10	n/a	n/a	n/a	n/a
National Institute of Pharmaceutical Education and Research (NIPER) Curated by ChEMBL					Assay Description Agonist activity at GAL4-tagged PPARalpha ligand-binding domain (unknown origin) expressed in HEK293T cells incubated for 16 to 19 hrs by beta-lactam...				Bioorg Med Chem Lett 25: 270-5 (2014) Article DOI: 10.1016/j.bmcl.2014.11.052 BindingDB Entry DOI: 10.7270/Q2S18434
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM28780 ((3E)-3-(butoxyimino)-2-({4-[2-(5-methyl-2-phenyl-1...) Show SMILES CCCCO\N=C(/C)C(Cc1ccc(OCCc2nc(oc2C)-c2ccccc2)cc1)C(O)=O Show InChI InChI=1S/C27H32N2O5/c1-4-5-16-33-29-19(2)24(27(30)31)18-21-11-13-23(14-12-21)32-17-15-25-20(3)34-26(28-25)22-9-7-6-8-10-22/h6-14,24H,4-5,15-18H2,1-3H3,(H,30,31)/b29-19+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.30	n/a	n/a	n/a	n/a
LG Life Sciences					Assay Description The HepG2 cells were co-transfected with DNA construct containing PPAR-Gal4 chimeric receptor and Gal4-luciferase reporter. EC50 is the concentration...				Bioorg Med Chem Lett 17: 937-41 (2007) Article DOI: 10.1016/j.bmcl.2006.11.050 BindingDB Entry DOI: 10.7270/Q2057D8J
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM539995 ((E)-2-(4-(3-(2,7-dimethoxy-quinolin-3-yl)-3-oxo-1-...) Show SMILES COc1ccc2cc(C(=O)\C=C\c3cc(C)c(OC(C)(C)C(O)=O)c(C)c3)c(OC)nc2c1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.33	n/a	n/a	n/a	n/a
TBA					Assay Description HEK293 cells were incubated in DMEM medium containing 10% of fetal bovine serum at 37° C. in the presence of 5% of CO2. 3×105/ml cells were plated in...				Citation and Details BindingDB Entry DOI: 10.7270/Q26H4MMP
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50099491 (2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...) Show SMILES CC(C)(Sc1ccc(CCN(CCCCC2CCCCC2)C(=O)NC2CCCCC2)cc1)C(O)=O Show InChI InChI=1S/C29H46N2O3S/c1-29(2,27(32)33)35-26-18-16-24(17-19-26)20-22-31(28(34)30-25-14-7-4-8-15-25)21-10-9-13-23-11-5-3-6-12-23/h16-19,23,25H,3-15,20-22H2,1-2H3,(H,30,34)(H,32,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	1.40	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at PPARalpha (unknown origin)				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c02002 BindingDB Entry DOI: 10.7270/Q2VQ36KV
					More data for this Ligand-Target Pair				3D Structure (crystal)
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50568098 (CHEMBL4877444) Show SMILES Cc1ccc(Cn2nc(CCCc3ccc(OC(C)(C)C(O)=O)cc3)n(Cc3ccccc3)c2=O)cc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.5	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at Gal4-fused human PPARalpha co-expressed with RXRalpha in monkey CV1 cells assessed as PPRE transcriptional activation incubated f...				Citation and Details Article DOI: 10.1016/j.bmc.2021.116193 BindingDB Entry DOI: 10.7270/Q2N01B8M
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50401638 (CHEMBL2204595) Show SMILES Cc1oc(nc1CN(Cc1ccco1)Cc1cc(C)c(OC(C)(C)C(O)=O)c(C)c1)-c1ccccc1 Show InChI InChI=1S/C29H32N2O5/c1-19-14-22(15-20(2)26(19)36-29(4,5)28(32)33)16-31(17-24-12-9-13-34-24)18-25-21(3)35-27(30-25)23-10-7-6-8-11-23/h6-15H,16-18H2,1-5H3,(H,32,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.70	n/a	n/a	n/a	n/a
Daiichi Sankyo Co., Ltd Curated by ChEMBL					Assay Description Agonist activity at GAL4-fused PPARalpha assessed as transcriptional activity by cell based assay				Bioorg Med Chem Lett 22: 7075-9 (2012) Article DOI: 10.1016/j.bmcl.2012.09.092 BindingDB Entry DOI: 10.7270/Q2HM59M5
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50099491 (2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...) Show SMILES CC(C)(Sc1ccc(CCN(CCCCC2CCCCC2)C(=O)NC2CCCCC2)cc1)C(O)=O Show InChI InChI=1S/C29H46N2O3S/c1-29(2,27(32)33)35-26-18-16-24(17-19-26)20-22-31(28(34)30-25-14-7-4-8-15-25)21-10-9-13-23-11-5-3-6-12-23/h16-19,23,25H,3-15,20-22H2,1-2H3,(H,30,34)(H,32,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	1.80	n/a	n/a	n/a	n/a
Trinity College Curated by ChEMBL					Assay Description Displacement of pan-PPAR fluormone from PPARalpha LBD by TR-FRET based LanthaScreen assay				J Med Chem 55: 4978-89 (2012) Article DOI: 10.1021/jm300068n BindingDB Entry DOI: 10.7270/Q2ZP4769
					More data for this Ligand-Target Pair				3D Structure (crystal)
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50349816 (CHEMBL1813009) Show SMILES CCO[C@@H](Cc1ccc(OCCc2nc(oc2C)-c2ccsc2)cc1)C(O)=O |r| Show InChI InChI=1S/C21H23NO5S/c1-3-25-19(21(23)24)12-15-4-6-17(7-5-15)26-10-8-18-14(2)27-20(22-18)16-9-11-28-13-16/h4-7,9,11,13,19H,3,8,10,12H2,1-2H3,(H,23,24)/t19-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.90	n/a	n/a	n/a	n/a
Zydus Research Centre Curated by ChEMBL					Assay Description Transactivation of human PPARalpha expressed in human HepG2 cells cotransfected with PPRE3-TK-Luc by luciferase reporter gene assay				Bioorg Med Chem Lett 21: 3103-9 (2011) Article DOI: 10.1016/j.bmcl.2011.03.020 BindingDB Entry DOI: 10.7270/Q2ZC837H
					More data for this Ligand-Target Pair

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