Found 52 hits Enz. Inhib. hit(s) with Target = 'Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
(Homo sapiens (Human)) | BDBM50535442
(CHEMBL4453882)Show SMILES COc1ccc(CCN(C)[C@@H]2CCC[C@@H](C2)N2CCc3cc(OC)c(OC)cc3CC2=O)cc1OC |r| Show InChI InChI=1S/C29H40N2O5/c1-30(13-11-20-9-10-25(33-2)26(15-20)34-3)23-7-6-8-24(19-23)31-14-12-21-16-27(35-4)28(36-5)17-22(21)18-29(31)32/h9-10,15-17,23-24H,6-8,11-14,18-19H2,1-5H3/t23-,24+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 3.98E+3 | n/a | n/a | n/a | n/a |
University of Florence
Curated by ChEMBL
| Assay Description
Inhibition of human HCN4 expressed in HEK293 cells assessed as reduction in hyperpolarization activated current at holding potential of -80 mV by pat... |
ACS Med Chem Lett 10: 584-589 (2019)
Article DOI: 10.1021/acsmedchemlett.8b00587
BindingDB Entry DOI: 10.7270/Q2M61PRS |
More data for this
Ligand-Target Pair | |
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
(Homo sapiens (Human)) | BDBM50326992
(CHEMBL471737 | ivabradine)Show SMILES COc1cc2C[C@H](CN(C)CCCN3CCc4cc(OC)c(OC)cc4CC3=O)c2cc1OC |r| Show InChI InChI=1S/C27H36N2O5/c1-28(17-21-11-20-14-25(33-4)26(34-5)16-22(20)21)8-6-9-29-10-7-18-12-23(31-2)24(32-3)13-19(18)15-27(29)30/h12-14,16,21H,6-11,15,17H2,1-5H3/t21-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | n/a | n/a | 4.28E+3 | n/a | n/a | n/a | n/a |
Laboratory of Design, Synthesis, and Study of Biologically Active Heterocycles (HeteroBioLab)
Curated by ChEMBL
| Assay Description
Blockade of human HCN4 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assay |
J Med Chem 53: 6773-7 (2010)
Article DOI: 10.1021/jm1006758
BindingDB Entry DOI: 10.7270/Q2T43T9J |
More data for this
Ligand-Target Pair | |
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
(Homo sapiens (Human)) | BDBM50326993
(3-((Z)-4-((3,4-dimethoxyphenethyl)(methyl)amino)bu...)Show SMILES COc1ccc(CCN(C)C\C=C/CN2C=Cc3cc(OC)c(OC)cc3CC2=O)cc1OC |c:15| Show InChI InChI=1S/C27H34N2O5/c1-28(14-10-20-8-9-23(31-2)24(16-20)32-3)12-6-7-13-29-15-11-21-17-25(33-4)26(34-5)18-22(21)19-27(29)30/h6-9,11,15-18H,10,12-14,19H2,1-5H3/b7-6- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 7.14E+3 | n/a | n/a | n/a | n/a |
Laboratory of Design, Synthesis, and Study of Biologically Active Heterocycles (HeteroBioLab)
Curated by ChEMBL
| Assay Description
Blockade of human HCN4 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assay |
J Med Chem 53: 6773-7 (2010)
Article DOI: 10.1021/jm1006758
BindingDB Entry DOI: 10.7270/Q2T43T9J |
More data for this
Ligand-Target Pair | |
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
(Homo sapiens (Human)) | BDBM50326991
(3-((E)-4-((3,4-dimethoxyphenethyl)(methyl)amino)bu...)Show SMILES COc1ccc(CCN(C)C\C=C\CN2C=Cc3cc(OC)c(OC)cc3CC2=O)cc1OC |c:15| Show InChI InChI=1S/C27H34N2O5/c1-28(14-10-20-8-9-23(31-2)24(16-20)32-3)12-6-7-13-29-15-11-21-17-25(33-4)26(34-5)18-22(21)19-27(29)30/h6-9,11,15-18H,10,12-14,19H2,1-5H3/b7-6+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 7.23E+3 | n/a | n/a | n/a | n/a |
Laboratory of Design, Synthesis, and Study of Biologically Active Heterocycles (HeteroBioLab)
Curated by ChEMBL
| Assay Description
Blockade of human HCN4 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assay |
J Med Chem 53: 6773-7 (2010)
Article DOI: 10.1021/jm1006758
BindingDB Entry DOI: 10.7270/Q2T43T9J |
More data for this
Ligand-Target Pair | |
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
(Homo sapiens (Human)) | BDBM50326988
(3-(3-{[2-(3,4-Dimethoxy-phenyl)-ethyl]-methyl-amin...)Show SMILES COc1ccc(CCN(C)CCCN2CCc3cc(OC)c(OC)cc3CC2=O)cc1OC Show InChI InChI=1S/C26H36N2O5/c1-27(13-9-19-7-8-22(30-2)23(15-19)31-3)11-6-12-28-14-10-20-16-24(32-4)25(33-5)17-21(20)18-26(28)29/h7-8,15-17H,6,9-14,18H2,1-5H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | n/a | n/a | 8.57E+3 | n/a | n/a | n/a | n/a |
Laboratory of Design, Synthesis, and Study of Biologically Active Heterocycles (HeteroBioLab)
Curated by ChEMBL
| Assay Description
Blockade of human HCN4 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assay |
J Med Chem 53: 6773-7 (2010)
Article DOI: 10.1021/jm1006758
BindingDB Entry DOI: 10.7270/Q2T43T9J |
More data for this
Ligand-Target Pair | |
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
(Mus musculus) | BDBM50535442
(CHEMBL4453882)Show SMILES COc1ccc(CCN(C)[C@@H]2CCC[C@@H](C2)N2CCc3cc(OC)c(OC)cc3CC2=O)cc1OC |r| Show InChI InChI=1S/C29H40N2O5/c1-30(13-11-20-9-10-25(33-2)26(15-20)34-3)23-7-6-8-24(19-23)31-14-12-21-16-27(35-4)28(36-5)17-22(21)18-29(31)32/h9-10,15-17,23-24H,6-8,11-14,18-19H2,1-5H3/t23-,24+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a |
University of Florence
Curated by ChEMBL
| Assay Description
Inhibition of HCN4 in C57BL/6J mouse thalamocortical relay neuron assessed as reduction in hyperpolarization current at holding potential of -120 mV ... |
ACS Med Chem Lett 10: 584-589 (2019)
Article DOI: 10.1021/acsmedchemlett.8b00587
BindingDB Entry DOI: 10.7270/Q2M61PRS |
More data for this
Ligand-Target Pair | |
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
(Homo sapiens (Human)) | BDBM50326989
(3-((Z)-4-(((R)-2-(3,4-dimethoxyphenyl)propyl)(meth...)Show SMILES COc1ccc(cc1OC)[C@@H](C)CN(C)C\C=C/CN1C=Cc2cc(OC)c(OC)cc2CC1=O |r,c:21| Show InChI InChI=1S/C28H36N2O5/c1-20(21-9-10-24(32-3)25(15-21)33-4)19-29(2)12-7-8-13-30-14-11-22-16-26(34-5)27(35-6)17-23(22)18-28(30)31/h7-11,14-17,20H,12-13,18-19H2,1-6H3/b8-7-/t20-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 2.49E+4 | n/a | n/a | n/a | n/a |
Laboratory of Design, Synthesis, and Study of Biologically Active Heterocycles (HeteroBioLab)
Curated by ChEMBL
| Assay Description
Blockade of human HCN4 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assay |
J Med Chem 53: 6773-7 (2010)
Article DOI: 10.1021/jm1006758
BindingDB Entry DOI: 10.7270/Q2T43T9J |
More data for this
Ligand-Target Pair | |
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
(Homo sapiens (Human)) | BDBM50326987
(3-((Z)-4-(((S)-2-(3,4-dimethoxyphenyl)propyl)(meth...)Show SMILES COc1ccc(cc1OC)[C@H](C)CN(C)C\C=C/CN1C=Cc2cc(OC)c(OC)cc2CC1=O |r,c:21| Show InChI InChI=1S/C28H36N2O5/c1-20(21-9-10-24(32-3)25(15-21)33-4)19-29(2)12-7-8-13-30-14-11-22-16-26(34-5)27(35-6)17-23(22)18-28(30)31/h7-11,14-17,20H,12-13,18-19H2,1-6H3/b8-7-/t20-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 3.16E+4 | n/a | n/a | n/a | n/a |
Laboratory of Design, Synthesis, and Study of Biologically Active Heterocycles (HeteroBioLab)
Curated by ChEMBL
| Assay Description
Blockade of human HCN4 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assay |
J Med Chem 53: 6773-7 (2010)
Article DOI: 10.1021/jm1006758
BindingDB Entry DOI: 10.7270/Q2T43T9J |
More data for this
Ligand-Target Pair | |
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
(Homo sapiens (Human)) | BDBM50326985
(3,3'-((2Z,2'Z)-4,4'-(3,4-dimethoxyphenethylazanedi...)Show SMILES COc1ccc(CCN(C\C=C/CN2C=Cc3cc(OC)c(OC)cc3CC2=O)C\C=C/CN2C=Cc3cc(OC)c(OC)cc3CC2=O)cc1OC |c:14,36| Show InChI InChI=1S/C42H49N3O8/c1-48-35-12-11-30(23-36(35)49-2)13-20-43(16-7-9-18-44-21-14-31-24-37(50-3)39(52-5)26-33(31)28-41(44)46)17-8-10-19-45-22-15-32-25-38(51-4)40(53-6)27-34(32)29-42(45)47/h7-12,14-15,21-27H,13,16-20,28-29H2,1-6H3/b9-7-,10-8- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 7.07E+4 | n/a | n/a | n/a | n/a |
Laboratory of Design, Synthesis, and Study of Biologically Active Heterocycles (HeteroBioLab)
Curated by ChEMBL
| Assay Description
Blockade of human HCN4 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assay |
J Med Chem 53: 6773-7 (2010)
Article DOI: 10.1021/jm1006758
BindingDB Entry DOI: 10.7270/Q2T43T9J |
More data for this
Ligand-Target Pair | |
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
(Homo sapiens (Human)) | BDBM50326990
(3,3'-((2Z,2'Z)-4,4'-((R)-2-(3,4-dimethoxyphenyl)pr...)Show SMILES COc1ccc(cc1OC)[C@@H](C)CN(C\C=C/CN1C=Cc2cc(OC)c(OC)cc2CC1=O)C\C=C/CN1C=Cc2cc(OC)c(OC)cc2CC1=O |r,c:20,42| Show InChI InChI=1S/C43H51N3O8/c1-30(31-12-13-36(49-2)37(22-31)50-3)29-44(16-8-10-18-45-20-14-32-23-38(51-4)40(53-6)25-34(32)27-42(45)47)17-9-11-19-46-21-15-33-24-39(52-5)41(54-7)26-35(33)28-43(46)48/h8-15,20-26,30H,16-19,27-29H2,1-7H3/b10-8-,11-9-/t30-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.04E+5 | n/a | n/a | n/a | n/a |
Laboratory of Design, Synthesis, and Study of Biologically Active Heterocycles (HeteroBioLab)
Curated by ChEMBL
| Assay Description
Blockade of human HCN4 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assay |
J Med Chem 53: 6773-7 (2010)
Article DOI: 10.1021/jm1006758
BindingDB Entry DOI: 10.7270/Q2T43T9J |
More data for this
Ligand-Target Pair | |
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
(Homo sapiens (Human)) | BDBM50326986
(3,3'-((2Z,2'Z)-4,4'-((S)-2-(3,4-dimethoxyphenyl)pr...)Show SMILES COc1ccc(cc1OC)[C@H](C)CN(C\C=C/CN1C=Cc2cc(OC)c(OC)cc2CC1=O)C\C=C/CN1C=Cc2cc(OC)c(OC)cc2CC1=O |r,c:20,42| Show InChI InChI=1S/C43H51N3O8/c1-30(31-12-13-36(49-2)37(22-31)50-3)29-44(16-8-10-18-45-20-14-32-23-38(51-4)40(53-6)25-34(32)27-42(45)47)17-9-11-19-46-21-15-33-24-39(52-5)41(54-7)26-35(33)28-43(46)48/h8-15,20-26,30H,16-19,27-29H2,1-7H3/b10-8-,11-9-/t30-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.36E+5 | n/a | n/a | n/a | n/a |
Laboratory of Design, Synthesis, and Study of Biologically Active Heterocycles (HeteroBioLab)
Curated by ChEMBL
| Assay Description
Blockade of human HCN4 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assay |
J Med Chem 53: 6773-7 (2010)
Article DOI: 10.1021/jm1006758
BindingDB Entry DOI: 10.7270/Q2T43T9J |
More data for this
Ligand-Target Pair | |
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
(Homo sapiens (Human)) | BDBM50419061
(CHEMBL1823675)Show InChI InChI=1S/C23H28N2O2/c1-27-21-12-6-5-11-20(21)22(26)24-17-23(25-13-7-2-8-14-25)15-18-9-3-4-10-19(18)16-23/h3-6,9-12H,2,7-8,13-17H2,1H3,(H,24,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human HCN4 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay |
Bioorg Med Chem Lett 21: 5197-201 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.051
BindingDB Entry DOI: 10.7270/Q2PV6MNP |
More data for this
Ligand-Target Pair | |
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
(Homo sapiens (Human)) | BDBM50419080
(CHEMBL1823677)Show InChI InChI=1S/C21H33N3O2/c1-3-26-19-10-6-5-9-18(19)20(25)22-17-21(11-7-4-8-12-21)24-15-13-23(2)14-16-24/h5-6,9-10H,3-4,7-8,11-17H2,1-2H3,(H,22,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.26E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human HCN4 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay |
Bioorg Med Chem Lett 21: 5197-201 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.051
BindingDB Entry DOI: 10.7270/Q2PV6MNP |
More data for this
Ligand-Target Pair | |
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
(Homo sapiens (Human)) | BDBM50419081
(CHEMBL1823679)Show InChI InChI=1S/C19H28ClN3O/c1-22-11-13-23(14-12-22)19(9-5-2-6-10-19)15-21-18(24)16-7-3-4-8-17(16)20/h3-4,7-8H,2,5-6,9-15H2,1H3,(H,21,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.16E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human HCN4 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay |
Bioorg Med Chem Lett 21: 5197-201 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.051
BindingDB Entry DOI: 10.7270/Q2PV6MNP |
More data for this
Ligand-Target Pair | |
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
(Homo sapiens (Human)) | BDBM50419064
(CHEMBL1823874)Show SMILES CCOc1ccccc1C(=O)NCC1(CCCCC1)N1CCN(CC1)C(C)C Show InChI InChI=1S/C23H37N3O2/c1-4-28-21-11-7-6-10-20(21)22(27)24-18-23(12-8-5-9-13-23)26-16-14-25(15-17-26)19(2)3/h6-7,10-11,19H,4-5,8-9,12-18H2,1-3H3,(H,24,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 316 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human HCN4 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay |
Bioorg Med Chem Lett 21: 5197-201 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.051
BindingDB Entry DOI: 10.7270/Q2PV6MNP |
More data for this
Ligand-Target Pair | |
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
(Homo sapiens (Human)) | BDBM50419066
(CHEMBL1823876)Show SMILES CC(C)Oc1ccccc1C(=O)NCC1(CCCCC1)N1CCN(CC1)C(C)C Show InChI InChI=1S/C24H39N3O2/c1-19(2)26-14-16-27(17-15-26)24(12-8-5-9-13-24)18-25-23(28)21-10-6-7-11-22(21)29-20(3)4/h6-7,10-11,19-20H,5,8-9,12-18H2,1-4H3,(H,25,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.58E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human HCN4 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay |
Bioorg Med Chem Lett 21: 5197-201 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.051
BindingDB Entry DOI: 10.7270/Q2PV6MNP |
More data for this
Ligand-Target Pair | |
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
(Homo sapiens (Human)) | BDBM50419082
(CHEMBL1823877)Show InChI InChI=1S/C23H37N3O/c1-4-20-10-6-7-11-21(20)22(27)24-18-23(12-8-5-9-13-23)26-16-14-25(15-17-26)19(2)3/h6-7,10-11,19H,4-5,8-9,12-18H2,1-3H3,(H,24,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.94E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human HCN4 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay |
Bioorg Med Chem Lett 21: 5197-201 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.051
BindingDB Entry DOI: 10.7270/Q2PV6MNP |
More data for this
Ligand-Target Pair | |
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
(Homo sapiens (Human)) | BDBM50419067
(CHEMBL1823878)Show InChI InChI=1S/C22H35N3O2/c1-3-24-14-16-25(17-15-24)22(12-8-5-9-13-22)18-23-21(26)19-10-6-7-11-20(19)27-4-2/h6-7,10-11H,3-5,8-9,12-18H2,1-2H3,(H,23,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
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| Purchase
CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 158 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human HCN4 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay |
Bioorg Med Chem Lett 21: 5197-201 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.051
BindingDB Entry DOI: 10.7270/Q2PV6MNP |
More data for this
Ligand-Target Pair | |
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
(Homo sapiens (Human)) | BDBM50419068
(CHEMBL1823879)Show SMILES CCOc1ccccc1C(=O)NCC1(CCCCC1)N1CCN(CC1)C1CC1 Show InChI InChI=1S/C23H35N3O2/c1-2-28-21-9-5-4-8-20(21)22(27)24-18-23(12-6-3-7-13-23)26-16-14-25(15-17-26)19-10-11-19/h4-5,8-9,19H,2-3,6-7,10-18H2,1H3,(H,24,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 316 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human HCN4 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay |
Bioorg Med Chem Lett 21: 5197-201 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.051
BindingDB Entry DOI: 10.7270/Q2PV6MNP |
More data for this
Ligand-Target Pair | |
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
(Homo sapiens (Human)) | BDBM50419070
(CHEMBL1823881)Show SMILES CCOc1ccccc1C(=O)NCC1(CCCCC1)N1CCN(CC1)C1CCCC1 Show InChI InChI=1S/C25H39N3O2/c1-2-30-23-13-7-6-12-22(23)24(29)26-20-25(14-8-3-9-15-25)28-18-16-27(17-19-28)21-10-4-5-11-21/h6-7,12-13,21H,2-5,8-11,14-20H2,1H3,(H,26,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 794 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human HCN4 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay |
Bioorg Med Chem Lett 21: 5197-201 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.051
BindingDB Entry DOI: 10.7270/Q2PV6MNP |
More data for this
Ligand-Target Pair | |
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
(Homo sapiens (Human)) | BDBM50419083
(CHEMBL1823882)Show InChI InChI=1S/C20H31N3O2/c1-2-25-18-9-5-4-8-17(18)19(24)22-16-20(10-6-3-7-11-20)23-14-12-21-13-15-23/h4-5,8-9,21H,2-3,6-7,10-16H2,1H3,(H,22,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
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| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.98E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human HCN4 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay |
Bioorg Med Chem Lett 21: 5197-201 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.051
BindingDB Entry DOI: 10.7270/Q2PV6MNP |
More data for this
Ligand-Target Pair | |
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
(Homo sapiens (Human)) | BDBM50419071
(CHEMBL1823883)Show InChI InChI=1S/C21H32N2O2/c1-2-25-19-12-6-5-11-18(19)20(24)22-17-21(13-7-3-8-14-21)23-15-9-4-10-16-23/h5-6,11-12H,2-4,7-10,13-17H2,1H3,(H,22,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.98E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human HCN4 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay |
Bioorg Med Chem Lett 21: 5197-201 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.051
BindingDB Entry DOI: 10.7270/Q2PV6MNP |
More data for this
Ligand-Target Pair | |
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
(Homo sapiens (Human)) | BDBM50419072
(CHEMBL1332972)Show InChI InChI=1S/C19H28N2O3/c1-23-17-8-4-3-7-16(17)18(22)20-15-19(9-5-2-6-10-19)21-11-13-24-14-12-21/h3-4,7-8H,2,5-6,9-15H2,1H3,(H,20,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
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| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.01E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human HCN4 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay |
Bioorg Med Chem Lett 21: 5197-201 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.051
BindingDB Entry DOI: 10.7270/Q2PV6MNP |
More data for this
Ligand-Target Pair | |
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
(Homo sapiens (Human)) | BDBM50419073
(CHEMBL1823884)Show SMILES CCOc1ccccc1C(=O)NCC1(CCCCC1)N1CCN(CC1)c1ccccc1 Show InChI InChI=1S/C26H35N3O2/c1-2-31-24-14-8-7-13-23(24)25(30)27-21-26(15-9-4-10-16-26)29-19-17-28(18-20-29)22-11-5-3-6-12-22/h3,5-8,11-14H,2,4,9-10,15-21H2,1H3,(H,27,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human HCN4 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay |
Bioorg Med Chem Lett 21: 5197-201 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.051
BindingDB Entry DOI: 10.7270/Q2PV6MNP |
More data for this
Ligand-Target Pair | |
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
(Homo sapiens (Human)) | BDBM50419084
(CHEMBL1823885)Show SMILES COc1ccccc1C(=O)NCC1(CCc2ccccc2C1)N1CCN(C)CC1 Show InChI InChI=1S/C24H31N3O2/c1-26-13-15-27(16-14-26)24(12-11-19-7-3-4-8-20(19)17-24)18-25-23(28)21-9-5-6-10-22(21)29-2/h3-10H,11-18H2,1-2H3,(H,25,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.31E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human HCN4 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay |
Bioorg Med Chem Lett 21: 5197-201 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.051
BindingDB Entry DOI: 10.7270/Q2PV6MNP |
More data for this
Ligand-Target Pair | |
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
(Homo sapiens (Human)) | BDBM50419085
(CHEMBL1823887)Show SMILES CCOc1ccccc1C(=O)NCC1(CCOCC1)N1CCN(CC1)C(C)C Show InChI InChI=1S/C22H35N3O3/c1-4-28-20-8-6-5-7-19(20)21(26)23-17-22(9-15-27-16-10-22)25-13-11-24(12-14-25)18(2)3/h5-8,18H,4,9-17H2,1-3H3,(H,23,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.98E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human HCN4 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay |
Bioorg Med Chem Lett 21: 5197-201 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.051
BindingDB Entry DOI: 10.7270/Q2PV6MNP |
More data for this
Ligand-Target Pair | |
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
(Homo sapiens (Human)) | BDBM50419075
(CHEMBL1823888)Show SMILES COc1ccccc1C(=O)NCC1(CCN(CC1)c1ccccc1)N1CCN(CC1)C(C)C Show InChI InChI=1S/C27H38N4O2/c1-22(2)29-17-19-31(20-18-29)27(13-15-30(16-14-27)23-9-5-4-6-10-23)21-28-26(32)24-11-7-8-12-25(24)33-3/h4-12,22H,13-21H2,1-3H3,(H,28,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.01E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human HCN4 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay |
Bioorg Med Chem Lett 21: 5197-201 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.051
BindingDB Entry DOI: 10.7270/Q2PV6MNP |
More data for this
Ligand-Target Pair | |
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
(Homo sapiens (Human)) | BDBM50419076
(CHEMBL1823889)Show InChI InChI=1S/C22H29N3O2/c1-17-8-10-18(11-9-17)20(25-14-12-24(2)13-15-25)16-23-22(26)19-6-4-5-7-21(19)27-3/h4-11,20H,12-16H2,1-3H3,(H,23,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human HCN4 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay |
Bioorg Med Chem Lett 21: 5197-201 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.051
BindingDB Entry DOI: 10.7270/Q2PV6MNP |
More data for this
Ligand-Target Pair | |
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
(Homo sapiens (Human)) | BDBM50419087
(CHEMBL1823676)Show InChI InChI=1S/C24H30N2O2/c1-2-28-22-13-7-6-12-21(22)23(27)25-18-24(26-14-8-3-9-15-26)16-19-10-4-5-11-20(19)17-24/h4-7,10-13H,2-3,8-9,14-18H2,1H3,(H,25,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.98E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human HCN4 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay |
Bioorg Med Chem Lett 21: 5197-201 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.051
BindingDB Entry DOI: 10.7270/Q2PV6MNP |
More data for this
Ligand-Target Pair | |
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
(Homo sapiens (Human)) | BDBM50419055
(CHEMBL1823666)Show SMILES CCOc1ccccc1C(=O)NCC1(Cc2ccccc2C1)N1CCN(C)CC1 Show InChI InChI=1S/C24H31N3O2/c1-3-29-22-11-7-6-10-21(22)23(28)25-18-24(27-14-12-26(2)13-15-27)16-19-8-4-5-9-20(19)17-24/h4-11H,3,12-18H2,1-2H3,(H,25,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.01E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human HCN4 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay |
Bioorg Med Chem Lett 21: 5197-201 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.051
BindingDB Entry DOI: 10.7270/Q2PV6MNP |
More data for this
Ligand-Target Pair | |
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
(Homo sapiens (Human)) | BDBM50419054
(CHEMBL1823665)Show SMILES COc1ccccc1C(=O)NCC1(Cc2ccccc2C1)N1CCN(C)CC1 Show InChI InChI=1S/C23H29N3O2/c1-25-11-13-26(14-12-25)23(15-18-7-3-4-8-19(18)16-23)17-24-22(27)20-9-5-6-10-21(20)28-2/h3-10H,11-17H2,1-2H3,(H,24,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human HCN4 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay |
Bioorg Med Chem Lett 21: 5197-201 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.051
BindingDB Entry DOI: 10.7270/Q2PV6MNP |
More data for this
Ligand-Target Pair | |
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
(Homo sapiens (Human)) | BDBM50419086
(CHEMBL1823671)Show SMILES CN1CCN(CC1)C1(CNC(=O)c2ccccc2Cl)Cc2ccccc2C1 Show InChI InChI=1S/C22H26ClN3O/c1-25-10-12-26(13-11-25)22(14-17-6-2-3-7-18(17)15-22)16-24-21(27)19-8-4-5-9-20(19)23/h2-9H,10-16H2,1H3,(H,24,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.58E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human HCN4 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay |
Bioorg Med Chem Lett 21: 5197-201 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.051
BindingDB Entry DOI: 10.7270/Q2PV6MNP |
More data for this
Ligand-Target Pair | |
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
(Homo sapiens (Human)) | BDBM50419062
(CHEMBL1435630)Show InChI InChI=1S/C20H31N3O2/c1-22-12-14-23(15-13-22)20(10-6-3-7-11-20)16-21-19(24)17-8-4-5-9-18(17)25-2/h4-5,8-9H,3,6-7,10-16H2,1-2H3,(H,21,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.01E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human HCN4 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay |
Bioorg Med Chem Lett 21: 5197-201 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.051
BindingDB Entry DOI: 10.7270/Q2PV6MNP |
More data for this
Ligand-Target Pair | |
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
(Homo sapiens (Human)) | BDBM50419065
(CHEMBL1823875)Show InChI InChI=1S/C22H35N3O2/c1-18(2)24-13-15-25(16-14-24)22(11-7-4-8-12-22)17-23-21(26)19-9-5-6-10-20(19)27-3/h5-6,9-10,18H,4,7-8,11-17H2,1-3H3,(H,23,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 794 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human HCN4 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay |
Bioorg Med Chem Lett 21: 5197-201 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.051
BindingDB Entry DOI: 10.7270/Q2PV6MNP |
More data for this
Ligand-Target Pair | |
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
(Homo sapiens (Human)) | BDBM50419069
(CHEMBL1823880)Show SMILES CCOc1ccccc1C(=O)NCC1(CCCCC1)N1CCN(CC1)C1CCC1 Show InChI InChI=1S/C24H37N3O2/c1-2-29-22-12-5-4-11-21(22)23(28)25-19-24(13-6-3-7-14-24)27-17-15-26(16-18-27)20-9-8-10-20/h4-5,11-12,20H,2-3,6-10,13-19H2,1H3,(H,25,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 794 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human HCN4 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay |
Bioorg Med Chem Lett 21: 5197-201 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.051
BindingDB Entry DOI: 10.7270/Q2PV6MNP |
More data for this
Ligand-Target Pair | |
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
(Homo sapiens (Human)) | BDBM50419074
(CHEMBL1823886)Show InChI InChI=1S/C20H31N3O2/c1-3-25-18-9-5-4-8-17(18)19(24)21-16-20(10-6-7-11-20)23-14-12-22(2)13-15-23/h4-5,8-9H,3,6-7,10-16H2,1-2H3,(H,21,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.01E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human HCN4 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay |
Bioorg Med Chem Lett 21: 5197-201 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.051
BindingDB Entry DOI: 10.7270/Q2PV6MNP |
More data for this
Ligand-Target Pair | |
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
(Homo sapiens (Human)) | BDBM50419063
(CHEMBL1823678)Show InChI InChI=1S/C20H31N3O/c1-17-8-4-5-9-18(17)19(24)21-16-20(10-6-3-7-11-20)23-14-12-22(2)13-15-23/h4-5,8-9H,3,6-7,10-16H2,1-2H3,(H,21,24) | PDB
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| n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human HCN4 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay |
Bioorg Med Chem Lett 21: 5197-201 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.051
BindingDB Entry DOI: 10.7270/Q2PV6MNP |
More data for this
Ligand-Target Pair | |
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
(Homo sapiens (Human)) | BDBM50257064
(CHEMBL2386850)Show InChI InChI=1S/C16H12FN5O2/c1-10-4-12(24-13-7-18-9-19-8-13)5-14(21-10)16(23)22-15-3-2-11(17)6-20-15/h2-9H,1H3,(H,20,22,23) | PDB
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Department of Radiology and Radiological Sciences, Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center , Nashville, Tennessee 37232, United States.
Curated by ChEMBL
| Assay Description
Inhibition of human HCN4 expressed in CHO cells by automated patch clamp assay |
J Med Chem 60: 5072-5085 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00410
BindingDB Entry DOI: 10.7270/Q2JH3PM7 |
More data for this
Ligand-Target Pair | |
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
(Homo sapiens (Human)) | BDBM50524101
(CHEMBL4474619)Show SMILES Cc1cc(n[nH]1)-c1ccc(cc1)C(=O)[C@@H]1CCCC[C@H]1C(=O)Nc1cnn(C)c1S(N)(=O)=O |r| Show InChI InChI=1S/C22H26N6O4S/c1-13-11-18(27-26-13)14-7-9-15(10-8-14)20(29)16-5-3-4-6-17(16)21(30)25-19-12-24-28(2)22(19)33(23,31)32/h7-12,16-17H,3-6H2,1-2H3,(H,25,30)(H,26,27)(H2,23,31,32)/t16-,17-/m1/s1 | PDB
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TBA
Curated by ChEMBL
| Assay Description
Inhibition of human HCN4 by Ion-work electrophysiology assay |
J Med Chem 62: 4312-4324 (2019)
Article DOI: 10.1021/acs.jmedchem.8b02004
BindingDB Entry DOI: 10.7270/Q25T3PXZ |
More data for this
Ligand-Target Pair | |
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
(Homo sapiens (Human)) | BDBM50524102
(CHEMBL4542281)Show SMILES Cc1cc(n[nH]1)-c1ccc(cc1)C(=O)[C@@H]1CCCC[C@H]1C(=O)Nc1cnn2CCNC(=O)c12 |r| Show InChI InChI=1S/C24H26N6O3/c1-14-12-19(29-28-14)15-6-8-16(9-7-15)22(31)17-4-2-3-5-18(17)23(32)27-20-13-26-30-11-10-25-24(33)21(20)30/h6-9,12-13,17-18H,2-5,10-11H2,1H3,(H,25,33)(H,27,32)(H,28,29)/t17-,18-/m1/s1 | PDB
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| n/a | n/a | >3.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human HCN4 by Ion-work electrophysiology assay |
J Med Chem 62: 4312-4324 (2019)
Article DOI: 10.1021/acs.jmedchem.8b02004
BindingDB Entry DOI: 10.7270/Q25T3PXZ |
More data for this
Ligand-Target Pair | |
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
(Homo sapiens (Human)) | BDBM50419060
(CHEMBL1823674)Show SMILES CCOc1ccccc1C(=O)NCC1(Cc2ccccc2C1)N1CCN(CC1)C(C)C Show InChI InChI=1S/C26H35N3O2/c1-4-31-24-12-8-7-11-23(24)25(30)27-19-26(17-21-9-5-6-10-22(21)18-26)29-15-13-28(14-16-29)20(2)3/h5-12,20H,4,13-19H2,1-3H3,(H,27,30) | PDB
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| n/a | n/a | 3.16E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human HCN4 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay |
Bioorg Med Chem Lett 21: 5197-201 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.051
BindingDB Entry DOI: 10.7270/Q2PV6MNP |
More data for this
Ligand-Target Pair | |
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
(Homo sapiens (Human)) | BDBM50419079
(CHEMBL1823673)Show InChI InChI=1S/C22H26FN3O/c1-25-10-12-26(13-11-25)22(14-17-6-2-3-7-18(17)15-22)16-24-21(27)19-8-4-5-9-20(19)23/h2-9H,10-16H2,1H3,(H,24,27) | PDB
MMDB
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UniChem
| Article
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| n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human HCN4 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay |
Bioorg Med Chem Lett 21: 5197-201 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.051
BindingDB Entry DOI: 10.7270/Q2PV6MNP |
More data for this
Ligand-Target Pair | |
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
(Homo sapiens (Human)) | BDBM50419059
(CHEMBL1823672)Show InChI InChI=1S/C22H27N3O2/c1-24-10-12-25(13-11-24)22(14-17-6-2-3-7-18(17)15-22)16-23-21(27)19-8-4-5-9-20(19)26/h2-9,26H,10-16H2,1H3,(H,23,27) | PDB
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| n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human HCN4 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay |
Bioorg Med Chem Lett 21: 5197-201 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.051
BindingDB Entry DOI: 10.7270/Q2PV6MNP |
More data for this
Ligand-Target Pair | |
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
(Homo sapiens (Human)) | BDBM50419058
(CHEMBL1823670)Show SMILES COc1ccc(cc1)C(=O)NCC1(Cc2ccccc2C1)N1CCN(C)CC1 Show InChI InChI=1S/C23H29N3O2/c1-25-11-13-26(14-12-25)23(15-19-5-3-4-6-20(19)16-23)17-24-22(27)18-7-9-21(28-2)10-8-18/h3-10H,11-17H2,1-2H3,(H,24,27) | PDB
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| n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human HCN4 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay |
Bioorg Med Chem Lett 21: 5197-201 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.051
BindingDB Entry DOI: 10.7270/Q2PV6MNP |
More data for this
Ligand-Target Pair | |
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
(Homo sapiens (Human)) | BDBM50419057
(CHEMBL1823669)Show SMILES COc1cccc(c1)C(=O)NCC1(Cc2ccccc2C1)N1CCN(C)CC1 Show InChI InChI=1S/C23H29N3O2/c1-25-10-12-26(13-11-25)23(15-19-6-3-4-7-20(19)16-23)17-24-22(27)18-8-5-9-21(14-18)28-2/h3-9,14H,10-13,15-17H2,1-2H3,(H,24,27) | PDB
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UniChem
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| n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human HCN4 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay |
Bioorg Med Chem Lett 21: 5197-201 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.051
BindingDB Entry DOI: 10.7270/Q2PV6MNP |
More data for this
Ligand-Target Pair | |
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
(Homo sapiens (Human)) | BDBM50419056
(CHEMBL1823668)Show SMILES CN1CCN(CC1)C1(CNC(=O)c2ccccc2OC(F)(F)F)Cc2ccccc2C1 Show InChI InChI=1S/C23H26F3N3O2/c1-28-10-12-29(13-11-28)22(14-17-6-2-3-7-18(17)15-22)16-27-21(30)19-8-4-5-9-20(19)31-23(24,25)26/h2-9H,10-16H2,1H3,(H,27,30) | PDB
MMDB
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| n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human HCN4 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay |
Bioorg Med Chem Lett 21: 5197-201 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.051
BindingDB Entry DOI: 10.7270/Q2PV6MNP |
More data for this
Ligand-Target Pair | |
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
(Homo sapiens (Human)) | BDBM50419078
(CHEMBL1823667)Show SMILES CN1CCN(CC1)C1(CNC(=O)c2ccccc2OCc2ccccc2)Cc2ccccc2C1 Show InChI InChI=1S/C29H33N3O2/c1-31-15-17-32(18-16-31)29(19-24-11-5-6-12-25(24)20-29)22-30-28(33)26-13-7-8-14-27(26)34-21-23-9-3-2-4-10-23/h2-14H,15-22H2,1H3,(H,30,33) | PDB
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| n/a | n/a | 2.51E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human HCN4 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay |
Bioorg Med Chem Lett 21: 5197-201 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.051
BindingDB Entry DOI: 10.7270/Q2PV6MNP |
More data for this
Ligand-Target Pair | |
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
(Homo sapiens (Human)) | BDBM50419053
(CHEMBL2052019 | ZD-7288)Show InChI InChI=1S/C15H20N4/c1-5-19(13-9-7-6-8-10-13)15-11-14(16-3)18(4)12(2)17-15/h6-11H,5H2,1-4H3/p+1 | PDB
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| n/a | n/a | 31.6 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human HCN4 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay |
Bioorg Med Chem Lett 21: 5197-201 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.051
BindingDB Entry DOI: 10.7270/Q2PV6MNP |
More data for this
Ligand-Target Pair | |
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
(Homo sapiens (Human)) | BDBM50428594
(CHEMBL2337981)Show SMILES CC(C)(C)NC(=O)NCCN1CCC(CO)(CNC(=O)c2cc(Cl)cc(Cl)c2)CC1 Show InChI InChI=1S/C21H32Cl2N4O3/c1-20(2,3)26-19(30)24-6-9-27-7-4-21(14-28,5-8-27)13-25-18(29)15-10-16(22)12-17(23)11-15/h10-12,28H,4-9,13-14H2,1-3H3,(H,25,29)(H2,24,26,30) | PDB
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AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human HCN4 channel expressed in CHO cells by IONWORKS patch clamp assay |
Bioorg Med Chem Lett 23: 119-24 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.140
BindingDB Entry DOI: 10.7270/Q26974X0 |
More data for this
Ligand-Target Pair | |
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
(Homo sapiens (Human)) | BDBM328993
(5-[[4-[[(2R)-morpholin-2-yl]methylamino]-5-(triflu...)Show SMILES FC(F)(F)c1cnc(Nc2cnc(cn2)C#N)cc1NC[C@H]1CNCCO1 |r| Show InChI InChI=1S/C16H16F3N7O/c17-16(18,19)12-8-25-14(26-15-9-22-10(4-20)5-24-15)3-13(12)23-7-11-6-21-1-2-27-11/h3,5,8-9,11,21H,1-2,6-7H2,(H2,23,24,25,26)/t11-/m1/s1 | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human HCN4 |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.5b01938
BindingDB Entry DOI: 10.7270/Q2MG7T5V |
More data for this
Ligand-Target Pair | |
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