Affinity Data by PubMed id=19748785

PubMed code 19748785

Found 115 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM3032 (CHEMBL1204168 \| CHEMBL29197 \| N-(3-bromophenyl)-6,...) Show SMILES COc1cc2ncnc(Nc3cccc(Br)c3)c2cc1OC Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	7.4	37
Duquesne University					Assay Description Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM33395 (2,4-diaminofuro[2,3-d]pyrimidine, 1b \| Z-isomer) Show SMILES COc1ccccc1\C(C)=C/c1coc2nc(N)nc(N)c12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM33402 (2,4-diaminofuro[2,3-d]pyrimidine, 8) Show SMILES CCCC(Cc1coc2nc(N)nc(N)c12)c1ccccc1OC Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	7.4	37
Duquesne University					Assay Description Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM4810 ((3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-...) Show SMILES Cc1cc(C)c(\C=C2/C(=O)Nc3ccccc23)[nH]1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	7.4	37
Duquesne University					Assay Description Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Dihydrofolate reductase (Mus musculus (Mouse))	BDBM33403 (2,4-diaminofuro[2,3-d]pyrimidine, 9) Show SMILES COc1ccccc1C(Cc1coc2nc(N)nc(N)c12)C(C)C Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	MMDB PC cid PC sid UniChem Similars	MMDB Article PubMed	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair				3D Structure (docked)
Dihydrofolate reductase (Mus musculus (Mouse))	BDBM33404 (2,4-diaminofuro[2,3-d]pyrimidine, 10) Show SMILES COc1ccccc1C(Cc1coc2nc(N)nc(N)c12)C1CC1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair				3D Structure (docked)
Dihydrofolate reductase (Mus musculus (Mouse))	BDBM33395 (2,4-diaminofuro[2,3-d]pyrimidine, 1b \| Z-isomer) Show SMILES COc1ccccc1\C(C)=C/c1coc2nc(N)nc(N)c12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair				3D Structure (crystal)
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM33395 (2,4-diaminofuro[2,3-d]pyrimidine, 1b \| Z-isomer) Show SMILES COc1ccccc1\C(C)=C/c1coc2nc(N)nc(N)c12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	3.94E+3	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM33394 (2,4-diaminofuro[2,3-d]pyrimidine, 1a \| E-isomer) Show SMILES COc1ccccc1\C(C)=C\c1coc2nc(N)nc(N)c12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Dihydrofolate reductase (Mus musculus (Mouse))	BDBM33397 (2,4-diaminofuro[2,3-d]pyrimidine, 3 \| E/Z ratio=3:...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	4.14E+3	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair				3D Structure (crystal)
Dihydrofolate reductase (Mus musculus (Mouse))	BDBM33401 (2,4-diaminofuro[2,3-d]pyrimidine, 7 \| E/Z ratio=3:...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM33404 (2,4-diaminofuro[2,3-d]pyrimidine, 10) Show SMILES COc1ccccc1C(Cc1coc2nc(N)nc(N)c12)C1CC1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.44E+3	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM33398 (2,4-diaminofuro[2,3-d]pyrimidine, 4 \| E/Z ratio=2:...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Dihydrofolate reductase (Mus musculus (Mouse))	BDBM33398 (2,4-diaminofuro[2,3-d]pyrimidine, 4 \| E/Z ratio=2:...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.64E+3	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM33403 (2,4-diaminofuro[2,3-d]pyrimidine, 9) Show SMILES COc1ccccc1C(Cc1coc2nc(N)nc(N)c12)C(C)C Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM33404 (2,4-diaminofuro[2,3-d]pyrimidine, 10) Show SMILES COc1ccccc1C(Cc1coc2nc(N)nc(N)c12)C1CC1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.01E+3	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM33403 (2,4-diaminofuro[2,3-d]pyrimidine, 9) Show SMILES COc1ccccc1C(Cc1coc2nc(N)nc(N)c12)C(C)C Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	MMDB PC cid PC sid UniChem Similars	MMDB Article PubMed	n/a	n/a	5.09E+3	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM33401 (2,4-diaminofuro[2,3-d]pyrimidine, 7 \| E/Z ratio=3:...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM33408 (AG1295 \| CHEMBL7724 \| cid_2048) Show SMILES Cc1cc2ncc(nc2cc1C)-c1ccccc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	6.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM33397 (2,4-diaminofuro[2,3-d]pyrimidine, 3 \| E/Z ratio=3:...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	6.35E+3	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair				3D Structure (crystal)
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM33403 (2,4-diaminofuro[2,3-d]pyrimidine, 9) Show SMILES COc1ccccc1C(Cc1coc2nc(N)nc(N)c12)C(C)C Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM33397 (2,4-diaminofuro[2,3-d]pyrimidine, 3 \| E/Z ratio=3:...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	7.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Dihydrofolate reductase (Mus musculus (Mouse))	BDBM33396 (2,4-diaminofuro[2,3-d]pyrimidine, 2 \| E/Z ratio=2:...) Show SMILES CCC\C(=C\c1coc2nc(N)nc(N)c12)c1ccccc1OC Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.92E+3	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM33401 (2,4-diaminofuro[2,3-d]pyrimidine, 7 \| E/Z ratio=3:...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.64E+3	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM33401 (2,4-diaminofuro[2,3-d]pyrimidine, 7 \| E/Z ratio=3:...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.64E+3	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM33404 (2,4-diaminofuro[2,3-d]pyrimidine, 10) Show SMILES COc1ccccc1C(Cc1coc2nc(N)nc(N)c12)C1CC1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.01E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM33395 (2,4-diaminofuro[2,3-d]pyrimidine, 1b \| Z-isomer) Show SMILES COc1ccccc1\C(C)=C/c1coc2nc(N)nc(N)c12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	1.02E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair				3D Structure (crystal)
Dihydrofolate reductase (Homo sapiens (Human))	BDBM33398 (2,4-diaminofuro[2,3-d]pyrimidine, 4 \| E/Z ratio=2:...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.02E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM33394 (2,4-diaminofuro[2,3-d]pyrimidine, 1a \| E-isomer) Show SMILES COc1ccccc1\C(C)=C\c1coc2nc(N)nc(N)c12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.03E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM33398 (2,4-diaminofuro[2,3-d]pyrimidine, 4 \| E/Z ratio=2:...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.03E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM33396 (2,4-diaminofuro[2,3-d]pyrimidine, 2 \| E/Z ratio=2:...) Show SMILES CCC\C(=C\c1coc2nc(N)nc(N)c12)c1ccccc1OC Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.18E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM33397 (2,4-diaminofuro[2,3-d]pyrimidine, 3 \| E/Z ratio=3:...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	1.19E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair				3D Structure (crystal)
Dihydrofolate reductase (Homo sapiens (Human))	BDBM33396 (2,4-diaminofuro[2,3-d]pyrimidine, 2 \| E/Z ratio=2:...) Show SMILES CCC\C(=C\c1coc2nc(N)nc(N)c12)c1ccccc1OC Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.22E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Dihydrofolate reductase (Pneumocystis carinii)	BDBM33404 (2,4-diaminofuro[2,3-d]pyrimidine, 10) Show SMILES COc1ccccc1C(Cc1coc2nc(N)nc(N)c12)C1CC1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.25E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM33403 (2,4-diaminofuro[2,3-d]pyrimidine, 9) Show SMILES COc1ccccc1C(Cc1coc2nc(N)nc(N)c12)C(C)C Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	MMDB PC cid PC sid UniChem Similars	MMDB Article PubMed	n/a	n/a	1.26E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM33394 (2,4-diaminofuro[2,3-d]pyrimidine, 1a \| E-isomer) Show SMILES COc1ccccc1\C(C)=C\c1coc2nc(N)nc(N)c12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.28E+4	n/a	n/a	n/a	n/a	7.4	37
Duquesne University					Assay Description Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM33405 (2,4-diaminofuro[2,3-d]pyrimidine, 11) Show SMILES CCCCC(Cc1coc2nc(N)nc(N)c12)c1ccccc1OC Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.34E+4	n/a	n/a	n/a	n/a	7.4	37
Duquesne University					Assay Description Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM33404 (2,4-diaminofuro[2,3-d]pyrimidine, 10) Show SMILES COc1ccccc1C(Cc1coc2nc(N)nc(N)c12)C1CC1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.37E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Dihydrofolate reductase (Mus musculus (Mouse))	BDBM33394 (2,4-diaminofuro[2,3-d]pyrimidine, 1a \| E-isomer) Show SMILES COc1ccccc1\C(C)=C\c1coc2nc(N)nc(N)c12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	1.45E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair				3D Structure (crystal)
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM33396 (2,4-diaminofuro[2,3-d]pyrimidine, 2 \| E/Z ratio=2:...) Show SMILES CCC\C(=C\c1coc2nc(N)nc(N)c12)c1ccccc1OC Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.52E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM33407 (2,4-diaminofuro[2,3-d]pyrimidine, 13) Show SMILES CCC(C)C(Cc1coc2nc(N)nc(N)c12)c1ccccc1OC Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.54E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM33394 (2,4-diaminofuro[2,3-d]pyrimidine, 1a \| E-isomer) Show SMILES COc1ccccc1\C(C)=C\c1coc2nc(N)nc(N)c12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	1.64E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair				3D Structure (crystal)
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM33407 (2,4-diaminofuro[2,3-d]pyrimidine, 13) Show SMILES CCC(C)C(Cc1coc2nc(N)nc(N)c12)c1ccccc1OC Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.74E+4	n/a	n/a	n/a	n/a	7.4	37
Duquesne University					Assay Description Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM33396 (2,4-diaminofuro[2,3-d]pyrimidine, 2 \| E/Z ratio=2:...) Show SMILES CCC\C(=C\c1coc2nc(N)nc(N)c12)c1ccccc1OC Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.78E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM33403 (2,4-diaminofuro[2,3-d]pyrimidine, 9) Show SMILES COc1ccccc1C(Cc1coc2nc(N)nc(N)c12)C(C)C Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.82E+4	n/a	n/a	n/a	n/a	7.4	37
Duquesne University					Assay Description Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM33394 (2,4-diaminofuro[2,3-d]pyrimidine, 1a \| E-isomer) Show SMILES COc1ccccc1\C(C)=C\c1coc2nc(N)nc(N)c12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	1.85E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair				3D Structure (crystal)
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM33405 (2,4-diaminofuro[2,3-d]pyrimidine, 11) Show SMILES CCCCC(Cc1coc2nc(N)nc(N)c12)c1ccccc1OC Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.96E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM33406 (2,4-diaminofuro[2,3-d]pyrimidine, 12) Show SMILES COc1ccccc1C(CC(C)C)Cc1coc2nc(N)nc(N)c12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.22E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Dihydrofolate reductase (Pneumocystis carinii)	BDBM33398 (2,4-diaminofuro[2,3-d]pyrimidine, 4 \| E/Z ratio=2:...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.22E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM33400 (2,4-diaminofuro[2,3-d]pyrimidine, 6 \| E/Z ratio=2:...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.49E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Dihydrofolate reductase (Pneumocystis carinii)	BDBM33399 (2,4-diaminofuro[2,3-d]pyrimidine, 5 \| E/Z ratio=3:...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.59E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM33402 (2,4-diaminofuro[2,3-d]pyrimidine, 8) Show SMILES CCCC(Cc1coc2nc(N)nc(N)c12)c1ccccc1OC Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	MMDB PC cid PC sid UniChem Similars	MMDB Article PubMed	n/a	n/a	2.59E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM33399 (2,4-diaminofuro[2,3-d]pyrimidine, 5 \| E/Z ratio=3:...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.99E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Dihydrofolate reductase (Pneumocystis carinii)	BDBM33395 (2,4-diaminofuro[2,3-d]pyrimidine, 1b \| Z-isomer) Show SMILES COc1ccccc1\C(C)=C/c1coc2nc(N)nc(N)c12 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM33402 (2,4-diaminofuro[2,3-d]pyrimidine, 8) Show SMILES CCCC(Cc1coc2nc(N)nc(N)c12)c1ccccc1OC Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM33399 (2,4-diaminofuro[2,3-d]pyrimidine, 5 \| E/Z ratio=3:...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.03E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM33395 (2,4-diaminofuro[2,3-d]pyrimidine, 1b \| Z-isomer) Show SMILES COc1ccccc1\C(C)=C/c1coc2nc(N)nc(N)c12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	3.03E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM33402 (2,4-diaminofuro[2,3-d]pyrimidine, 8) Show SMILES CCCC(Cc1coc2nc(N)nc(N)c12)c1ccccc1OC Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	MMDB PC cid PC sid UniChem Similars	MMDB Article PubMed	n/a	n/a	3.08E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Dihydrofolate reductase (Pneumocystis carinii)	BDBM33405 (2,4-diaminofuro[2,3-d]pyrimidine, 11) Show SMILES CCCCC(Cc1coc2nc(N)nc(N)c12)c1ccccc1OC Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.09E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Dihydrofolate reductase (Mus musculus (Mouse))	BDBM33399 (2,4-diaminofuro[2,3-d]pyrimidine, 5 \| E/Z ratio=3:...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.12E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM33399 (2,4-diaminofuro[2,3-d]pyrimidine, 5 \| E/Z ratio=3:...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.33E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Dihydrofolate reductase (Pneumocystis carinii)	BDBM33397 (2,4-diaminofuro[2,3-d]pyrimidine, 3 \| E/Z ratio=3:...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	3.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM33407 (2,4-diaminofuro[2,3-d]pyrimidine, 13) Show SMILES CCC(C)C(Cc1coc2nc(N)nc(N)c12)c1ccccc1OC Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.45E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Dihydrofolate reductase (Mus musculus (Mouse))	BDBM33406 (2,4-diaminofuro[2,3-d]pyrimidine, 12) Show SMILES COc1ccccc1C(CC(C)C)Cc1coc2nc(N)nc(N)c12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	MMDB PC cid PC sid UniChem Similars	MMDB Article PubMed	n/a	n/a	3.54E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair				3D Structure (docked)
Dihydrofolate reductase (Pneumocystis carinii)	BDBM33396 (2,4-diaminofuro[2,3-d]pyrimidine, 2 \| E/Z ratio=2:...) Show SMILES CCC\C(=C\c1coc2nc(N)nc(N)c12)c1ccccc1OC Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM33406 (2,4-diaminofuro[2,3-d]pyrimidine, 12) Show SMILES COc1ccccc1C(CC(C)C)Cc1coc2nc(N)nc(N)c12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	MMDB PC cid PC sid UniChem Similars	MMDB Article PubMed	n/a	n/a	3.93E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Dihydrofolate reductase (Pneumocystis carinii)	BDBM33406 (2,4-diaminofuro[2,3-d]pyrimidine, 12) Show SMILES COc1ccccc1C(CC(C)C)Cc1coc2nc(N)nc(N)c12 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM33407 (2,4-diaminofuro[2,3-d]pyrimidine, 13) Show SMILES CCC(C)C(Cc1coc2nc(N)nc(N)c12)c1ccccc1OC Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.21E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Dihydrofolate reductase (Pneumocystis carinii)	BDBM33402 (2,4-diaminofuro[2,3-d]pyrimidine, 8) Show SMILES CCCC(Cc1coc2nc(N)nc(N)c12)c1ccccc1OC Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.25E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM33400 (2,4-diaminofuro[2,3-d]pyrimidine, 6 \| E/Z ratio=2:...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.39E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Dihydrofolate reductase (Mus musculus (Mouse))	BDBM33407 (2,4-diaminofuro[2,3-d]pyrimidine, 13) Show SMILES CCC(C)C(Cc1coc2nc(N)nc(N)c12)c1ccccc1OC Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.45E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair				3D Structure (docked)
Dihydrofolate reductase (Pneumocystis carinii)	BDBM33407 (2,4-diaminofuro[2,3-d]pyrimidine, 13) Show SMILES CCC(C)C(Cc1coc2nc(N)nc(N)c12)c1ccccc1OC Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.51E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM33405 (2,4-diaminofuro[2,3-d]pyrimidine, 11) Show SMILES CCCCC(Cc1coc2nc(N)nc(N)c12)c1ccccc1OC Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	MMDB PC cid PC sid UniChem Similars	MMDB Article PubMed	n/a	n/a	4.67E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM33394 (2,4-diaminofuro[2,3-d]pyrimidine, 1a \| E-isomer) Show SMILES COc1ccccc1\C(C)=C\c1coc2nc(N)nc(N)c12 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	7.4	37
Duquesne University					Assay Description Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Dihydrofolate reductase (Mus musculus (Mouse))	BDBM33400 (2,4-diaminofuro[2,3-d]pyrimidine, 6 \| E/Z ratio=2:...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.19E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Dihydrofolate reductase (Pneumocystis carinii)	BDBM33400 (2,4-diaminofuro[2,3-d]pyrimidine, 6 \| E/Z ratio=2:...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.26E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Dihydrofolate reductase (Pneumocystis carinii)	BDBM33403 (2,4-diaminofuro[2,3-d]pyrimidine, 9) Show SMILES COc1ccccc1C(Cc1coc2nc(N)nc(N)c12)C(C)C Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.36E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Dihydrofolate reductase (Pneumocystis carinii)	BDBM33401 (2,4-diaminofuro[2,3-d]pyrimidine, 7 \| E/Z ratio=3:...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM33404 (2,4-diaminofuro[2,3-d]pyrimidine, 10) Show SMILES COc1ccccc1C(Cc1coc2nc(N)nc(N)c12)C1CC1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.65E+4	n/a	n/a	n/a	n/a	7.4	37
Duquesne University					Assay Description Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM33406 (2,4-diaminofuro[2,3-d]pyrimidine, 12) Show SMILES COc1ccccc1C(CC(C)C)Cc1coc2nc(N)nc(N)c12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	MMDB PC cid PC sid UniChem Similars	MMDB Article PubMed	n/a	n/a	6.27E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Dihydrofolate reductase (Pneumocystis carinii)	BDBM33394 (2,4-diaminofuro[2,3-d]pyrimidine, 1a \| E-isomer) Show SMILES COc1ccccc1\C(C)=C\c1coc2nc(N)nc(N)c12 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	7.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM33400 (2,4-diaminofuro[2,3-d]pyrimidine, 6 \| E/Z ratio=2:...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.65E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM33396 (2,4-diaminofuro[2,3-d]pyrimidine, 2 \| E/Z ratio=2:...) Show SMILES CCC\C(=C\c1coc2nc(N)nc(N)c12)c1ccccc1OC Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.82E+4	n/a	n/a	n/a	n/a	7.4	37
Duquesne University					Assay Description Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM33405 (2,4-diaminofuro[2,3-d]pyrimidine, 11) Show SMILES CCCCC(Cc1coc2nc(N)nc(N)c12)c1ccccc1OC Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	MMDB PC cid PC sid UniChem Similars	MMDB Article PubMed	n/a	n/a	9.39E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM33397 (2,4-diaminofuro[2,3-d]pyrimidine, 3 \| E/Z ratio=3:...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.11E+5	n/a	n/a	n/a	n/a	7.4	37
Duquesne University					Assay Description Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM33403 (2,4-diaminofuro[2,3-d]pyrimidine, 9) Show SMILES COc1ccccc1C(Cc1coc2nc(N)nc(N)c12)C(C)C Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.18E+5	n/a	n/a	n/a	n/a	7.4	37
Duquesne University					Assay Description Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM33395 (2,4-diaminofuro[2,3-d]pyrimidine, 1b \| Z-isomer) Show SMILES COc1ccccc1\C(C)=C/c1coc2nc(N)nc(N)c12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.52E+5	n/a	n/a	n/a	n/a	7.4	37
Duquesne University					Assay Description Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM33396 (2,4-diaminofuro[2,3-d]pyrimidine, 2 \| E/Z ratio=2:...) Show SMILES CCC\C(=C\c1coc2nc(N)nc(N)c12)c1ccccc1OC Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60E+5	n/a	n/a	n/a	n/a	7.4	37
Duquesne University					Assay Description Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Dihydrofolate reductase (Mus musculus (Mouse))	BDBM33402 (2,4-diaminofuro[2,3-d]pyrimidine, 8) Show SMILES CCCC(Cc1coc2nc(N)nc(N)c12)c1ccccc1OC Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	MMDB PC cid PC sid UniChem Similars	MMDB Article PubMed	n/a	n/a	1.62E+5	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair				3D Structure (docked)
Dihydrofolate reductase (Mus musculus (Mouse))	BDBM33405 (2,4-diaminofuro[2,3-d]pyrimidine, 11) Show SMILES CCCCC(Cc1coc2nc(N)nc(N)c12)c1ccccc1OC Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	MMDB PC cid PC sid UniChem Similars	MMDB Article PubMed	n/a	n/a	1.87E+5	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair				3D Structure (docked)
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM33404 (2,4-diaminofuro[2,3-d]pyrimidine, 10) Show SMILES COc1ccccc1C(Cc1coc2nc(N)nc(N)c12)C1CC1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	7.4	37
Duquesne University					Assay Description Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM33407 (2,4-diaminofuro[2,3-d]pyrimidine, 13) Show SMILES CCC(C)C(Cc1coc2nc(N)nc(N)c12)c1ccccc1OC Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	7.4	37
Duquesne University					Assay Description Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM33400 (2,4-diaminofuro[2,3-d]pyrimidine, 6 \| E/Z ratio=2:...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	7.4	37
Duquesne University					Assay Description Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM33406 (2,4-diaminofuro[2,3-d]pyrimidine, 12) Show SMILES COc1ccccc1C(CC(C)C)Cc1coc2nc(N)nc(N)c12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	7.4	37
Duquesne University					Assay Description Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM33400 (2,4-diaminofuro[2,3-d]pyrimidine, 6 \| E/Z ratio=2:...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	7.4	37
Duquesne University					Assay Description Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM33405 (2,4-diaminofuro[2,3-d]pyrimidine, 11) Show SMILES CCCCC(Cc1coc2nc(N)nc(N)c12)c1ccccc1OC Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	7.4	37
Duquesne University					Assay Description Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM33398 (2,4-diaminofuro[2,3-d]pyrimidine, 4 \| E/Z ratio=2:...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	7.4	37
Duquesne University					Assay Description Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM33401 (2,4-diaminofuro[2,3-d]pyrimidine, 7 \| E/Z ratio=3:...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	7.4	37
Duquesne University					Assay Description Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM33397 (2,4-diaminofuro[2,3-d]pyrimidine, 3 \| E/Z ratio=3:...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	7.4	37
Duquesne University					Assay Description Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM33399 (2,4-diaminofuro[2,3-d]pyrimidine, 5 \| E/Z ratio=3:...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	7.4	37
Duquesne University					Assay Description Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM33401 (2,4-diaminofuro[2,3-d]pyrimidine, 7 \| E/Z ratio=3:...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	7.4	37
Duquesne University					Assay Description Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM33398 (2,4-diaminofuro[2,3-d]pyrimidine, 4 \| E/Z ratio=2:...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	7.4	37
Duquesne University					Assay Description Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM33402 (2,4-diaminofuro[2,3-d]pyrimidine, 8) Show SMILES CCCC(Cc1coc2nc(N)nc(N)c12)c1ccccc1OC Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	7.4	37
Duquesne University					Assay Description Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM33395 (2,4-diaminofuro[2,3-d]pyrimidine, 1b \| Z-isomer) Show SMILES COc1ccccc1\C(C)=C/c1coc2nc(N)nc(N)c12 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	7.4	37
Duquesne University					Assay Description Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM33402 (2,4-diaminofuro[2,3-d]pyrimidine, 8) Show SMILES CCCC(Cc1coc2nc(N)nc(N)c12)c1ccccc1OC Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM33406 (2,4-diaminofuro[2,3-d]pyrimidine, 12) Show SMILES COc1ccccc1C(CC(C)C)Cc1coc2nc(N)nc(N)c12 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+5	n/a	n/a	n/a	n/a	7.4	37
Duquesne University					Assay Description Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM33405 (2,4-diaminofuro[2,3-d]pyrimidine, 11) Show SMILES CCCCC(Cc1coc2nc(N)nc(N)c12)c1ccccc1OC Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM33401 (2,4-diaminofuro[2,3-d]pyrimidine, 7 \| E/Z ratio=3:...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM33400 (2,4-diaminofuro[2,3-d]pyrimidine, 6 \| E/Z ratio=2:...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM33398 (2,4-diaminofuro[2,3-d]pyrimidine, 4 \| E/Z ratio=2:...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM33406 (2,4-diaminofuro[2,3-d]pyrimidine, 12) Show SMILES COc1ccccc1C(CC(C)C)Cc1coc2nc(N)nc(N)c12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM33407 (2,4-diaminofuro[2,3-d]pyrimidine, 13) Show SMILES CCC(C)C(Cc1coc2nc(N)nc(N)c12)c1ccccc1OC Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM33399 (2,4-diaminofuro[2,3-d]pyrimidine, 5 \| E/Z ratio=3:...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM33397 (2,4-diaminofuro[2,3-d]pyrimidine, 3 \| E/Z ratio=3:...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>5.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM33399 (2,4-diaminofuro[2,3-d]pyrimidine, 5 \| E/Z ratio=3:...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.29E+5	n/a	n/a	n/a	n/a	7.4	37
Duquesne University					Assay Description Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair

* indicates data uncertainty>20%