Found 139 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072123
(CHEMBL3407904)Show InChI InChI=1S/C11H6ClFN2O2/c12-7-3-1-2-6(10(7)13)8-4-9(11(16)17)15-5-14-8/h1-5H,(H,16,17) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072078
(CHEMBL3407905)Show InChI InChI=1S/C11H6F2N2O2/c12-7-2-1-6(3-8(7)13)9-4-10(11(16)17)15-5-14-9/h1-5H,(H,16,17) | PDB
Reactome pathway
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| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072120
(CHEMBL3407901)Show InChI InChI=1S/C11H7FN2O2/c12-8-3-1-2-7(4-8)9-5-10(11(15)16)14-6-13-9/h1-6H,(H,15,16) | PDB
Reactome pathway
KEGG
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| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072122
(CHEMBL3407903)Show InChI InChI=1S/C11H6ClFN2O2/c12-7-2-1-6(3-8(7)13)9-4-10(11(16)17)15-5-14-9/h1-5H,(H,16,17) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072082
(CHEMBL3407865)Show InChI InChI=1S/C11H7ClN2O2/c12-8-3-1-2-7(4-8)9-5-10(11(15)16)14-6-13-9/h1-6H,(H,15,16) | PDB
Reactome pathway
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| Purchase
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PC cid
PC sid
UniChem
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PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072081
(CHEMBL3407922)Show InChI InChI=1S/C14H11ClN2O3/c15-10-5-8(1-4-13(10)20-9-2-3-9)11-6-12(14(18)19)17-7-16-11/h1,4-7,9H,2-3H2,(H,18,19) | PDB
Reactome pathway
KEGG
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072077
(CHEMBL3407866)Show InChI InChI=1S/C11H6Cl2N2O2/c12-7-2-1-6(3-8(7)13)9-4-10(11(16)17)15-5-14-9/h1-5H,(H,16,17) | PDB
Reactome pathway
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| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072079
(CHEMBL3407913)Show InChI InChI=1S/C12H9ClN2O2/c1-7-2-3-8(4-9(7)13)10-5-11(12(16)17)15-6-14-10/h2-6H,1H3,(H,16,17) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072131
(CHEMBL3407914)Show InChI InChI=1S/C12H9FN2O2/c1-7-2-3-8(4-9(7)13)10-5-11(12(16)17)15-6-14-10/h2-6H,1H3,(H,16,17) | PDB
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CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072121
(CHEMBL3407902)Show InChI InChI=1S/C11H6ClFN2O2/c12-7-3-6(1-2-8(7)13)9-4-10(11(16)17)15-5-14-9/h1-5H,(H,16,17) | PDB
Reactome pathway
KEGG
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GoogleScholar
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| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072136
(CHEMBL3407920)Show InChI InChI=1S/C12H9ClN2O3/c1-18-11-3-2-7(4-8(11)13)9-5-10(12(16)17)15-6-14-9/h2-6H,1H3,(H,16,17) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072143
(CHEMBL3407924)Show InChI InChI=1S/C13H8N2O3/c16-13(17)11-6-10(14-7-15-11)8-1-2-12-9(5-8)3-4-18-12/h1-7H,(H,16,17) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Mus musculus) | BDBM50072078
(CHEMBL3407905)Show InChI InChI=1S/C11H6F2N2O2/c12-7-2-1-6(3-8(7)13)9-4-10(11(16)17)15-5-14-9/h1-5H,(H,16,17) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of mouse KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072101
(CHEMBL3407883)Show InChI InChI=1S/C11H6Cl2N6/c12-7-2-1-6(3-8(7)13)9-4-10(15-5-14-9)11-16-18-19-17-11/h1-5H,(H,16,17,18,19) | PDB
Reactome pathway
KEGG
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50072078
(CHEMBL3407905)Show InChI InChI=1S/C11H6F2N2O2/c12-7-2-1-6(3-8(7)13)9-4-10(11(16)17)15-5-14-9/h1-5H,(H,16,17) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of rat KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072175
(CHEMBL3407926)Show InChI InChI=1S/C14H11ClN2O4/c15-10-3-8(1-2-13(10)21-9-5-20-6-9)11-4-12(14(18)19)17-7-16-11/h1-4,7,9H,5-6H2,(H,18,19) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072080
(CHEMBL3407919)Show InChI InChI=1S/C12H6ClF3N2O3/c13-7-3-6(1-2-10(7)21-12(14,15)16)8-4-9(11(19)20)18-5-17-8/h1-5H,(H,19,20) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072092
(CHEMBL3407874)Show InChI InChI=1S/C12H7Cl2NO2/c13-9-2-1-7(5-10(9)14)8-3-4-15-11(6-8)12(16)17/h1-6H,(H,16,17) | PDB
Reactome pathway
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| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50072077
(CHEMBL3407866)Show InChI InChI=1S/C11H6Cl2N2O2/c12-7-2-1-6(3-8(7)13)9-4-10(11(16)17)15-5-14-9/h1-5H,(H,16,17) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of rat KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50072081
(CHEMBL3407922)Show InChI InChI=1S/C14H11ClN2O3/c15-10-5-8(1-4-13(10)20-9-2-3-9)11-6-12(14(18)19)17-7-16-11/h1,4-7,9H,2-3H2,(H,18,19) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of rat KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50072079
(CHEMBL3407913)Show InChI InChI=1S/C12H9ClN2O2/c1-7-2-3-8(4-9(7)13)10-5-11(12(16)17)15-6-14-10/h2-6H,1H3,(H,16,17) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of rat KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072126
(CHEMBL3407908)Show InChI InChI=1S/C12H6ClF3N2O2/c13-8-3-6(1-2-7(8)12(14,15)16)9-4-10(11(19)20)18-5-17-9/h1-5H,(H,19,20) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Mus musculus) | BDBM50072081
(CHEMBL3407922)Show InChI InChI=1S/C14H11ClN2O3/c15-10-5-8(1-4-13(10)20-9-2-3-9)11-6-12(14(18)19)17-7-16-11/h1,4-7,9H,2-3H2,(H,18,19) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of mouse KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072141
(CHEMBL3407921)Show InChI InChI=1S/C14H13ClN2O3/c1-8(2)20-13-4-3-9(5-10(13)15)11-6-12(14(18)19)17-7-16-11/h3-8H,1-2H3,(H,18,19) | PDB
Reactome pathway
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| CHEMBL
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072095
(CHEMBL3407877)Show InChI InChI=1S/C11H5Cl2FN2O2/c12-6-2-1-5(3-7(6)13)9-8(14)10(11(17)18)16-4-15-9/h1-4H,(H,17,18) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Mus musculus) | BDBM50072077
(CHEMBL3407866)Show InChI InChI=1S/C11H6Cl2N2O2/c12-7-2-1-6(3-8(7)13)9-4-10(11(16)17)15-5-14-9/h1-5H,(H,16,17) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of mouse KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Mus musculus) | BDBM50072079
(CHEMBL3407913)Show InChI InChI=1S/C12H9ClN2O2/c1-7-2-3-8(4-9(7)13)10-5-11(12(16)17)15-6-14-10/h2-6H,1H3,(H,16,17) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of mouse KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072081
(CHEMBL3407922)Show InChI InChI=1S/C14H11ClN2O3/c15-10-5-8(1-4-13(10)20-9-2-3-9)11-6-12(14(18)19)17-7-16-11/h1,4-7,9H,2-3H2,(H,18,19) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO transfected in CHO cells assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072098
(CHEMBL3407880)Show InChI InChI=1S/C12H8Cl2N2O2/c1-6-10(15-5-16-11(6)12(17)18)7-2-3-8(13)9(14)4-7/h2-5H,1H3,(H,17,18) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Mus musculus) | BDBM50072080
(CHEMBL3407919)Show InChI InChI=1S/C12H6ClF3N2O3/c13-7-3-6(1-2-10(7)21-12(14,15)16)8-4-9(11(19)20)18-5-17-8/h1-5H,(H,19,20) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of mouse KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072080
(CHEMBL3407919)Show InChI InChI=1S/C12H6ClF3N2O3/c13-7-3-6(1-2-10(7)21-12(14,15)16)8-4-9(11(19)20)18-5-17-8/h1-5H,(H,19,20) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO transfected in CHO cells assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072118
(CHEMBL3407899)Show InChI InChI=1S/C11H7ClN2O2/c12-8-3-1-7(2-4-8)9-5-10(11(15)16)14-6-13-9/h1-6H,(H,15,16) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072167
(CHEMBL3407925)Show InChI InChI=1S/C15H13ClN2O3/c16-11-6-9(4-5-14(11)21-10-2-1-3-10)12-7-13(15(19)20)18-8-17-12/h4-8,10H,1-3H2,(H,19,20) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072094
(CHEMBL3407876)Show InChI InChI=1S/C12H8Cl2N2O2/c1-6-15-10(5-11(16-6)12(17)18)7-2-3-8(13)9(14)4-7/h2-5H,1H3,(H,17,18) | PDB
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| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072102
(CHEMBL3407884)Show InChI InChI=1S/C12H6Cl2N4O2/c13-7-2-1-6(3-8(7)14)9-4-10(16-5-15-9)11-17-12(19)20-18-11/h1-5H,(H,17,18,19) | PDB
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| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072122
(CHEMBL3407903)Show InChI InChI=1S/C11H6ClFN2O2/c12-7-2-1-6(3-8(7)13)9-4-10(11(16)17)15-5-14-9/h1-5H,(H,16,17) | PDB
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| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO transfected in CHO cells assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072136
(CHEMBL3407920)Show InChI InChI=1S/C12H9ClN2O3/c1-18-11-3-2-7(4-8(11)13)9-5-10(12(16)17)15-6-14-9/h2-6H,1H3,(H,16,17) | PDB
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| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO transfected in CHO cells assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072129
(CHEMBL3407911)Show InChI InChI=1S/C12H10N2O2/c1-8-3-2-4-9(5-8)10-6-11(12(15)16)14-7-13-10/h2-7H,1H3,(H,15,16) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50072080
(CHEMBL3407919)Show InChI InChI=1S/C12H6ClF3N2O3/c13-7-3-6(1-2-10(7)21-12(14,15)16)8-4-9(11(19)20)18-5-17-8/h1-5H,(H,19,20) | PDB
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| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of rat KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072119
(CHEMBL3407900)Show InChI InChI=1S/C11H6Cl2N2O2/c12-7-1-6(2-8(13)3-7)9-4-10(11(16)17)15-5-14-9/h1-5H,(H,16,17) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072083
(CHEMBL3407929)Show SMILES OC(=O)[C@H]1C[C@@H]1C(=O)c1ccc(Cl)c(Cl)c1 |r| Show InChI InChI=1S/C11H8Cl2O3/c12-8-2-1-5(3-9(8)13)10(14)6-4-7(6)11(15)16/h1-3,6-7H,4H2,(H,15,16)/t6-,7-/m0/s1 | PDB
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| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of KMO (unknown origin) |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072143
(CHEMBL3407924)Show InChI InChI=1S/C13H8N2O3/c16-13(17)11-6-10(14-7-15-11)8-1-2-12-9(5-8)3-4-18-12/h1-7H,(H,16,17) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO transfected in CHO cells assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072127
(CHEMBL3407909)Show InChI InChI=1S/C12H7F3N2O2/c13-12(14,15)8-3-1-2-7(4-8)9-5-10(11(18)19)17-6-16-9/h1-6H,(H,18,19) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072141
(CHEMBL3407921)Show InChI InChI=1S/C14H13ClN2O3/c1-8(2)20-13-4-3-9(5-10(13)15)11-6-12(14(18)19)17-7-16-11/h3-8H,1-2H3,(H,18,19) | PDB
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| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO transfected in CHO cells assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072167
(CHEMBL3407925)Show InChI InChI=1S/C15H13ClN2O3/c16-11-6-9(4-5-14(11)21-10-2-1-3-10)12-7-13(15(19)20)18-8-17-12/h4-8,10H,1-3H2,(H,19,20) | PDB
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| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO transfected in CHO cells assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072103
(CHEMBL3407885)Show SMILES Clc1ccc(cc1Cl)-c1cc(ncn1)C(=O)NS(=O)(=O)c1ccccc1 Show InChI InChI=1S/C17H11Cl2N3O3S/c18-13-7-6-11(8-14(13)19)15-9-16(21-10-20-15)17(23)22-26(24,25)12-4-2-1-3-5-12/h1-10H,(H,22,23) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072079
(CHEMBL3407913)Show InChI InChI=1S/C12H9ClN2O2/c1-7-2-3-8(4-9(7)13)10-5-11(12(16)17)15-6-14-10/h2-6H,1H3,(H,16,17) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO transfected in CHO cells assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072130
(CHEMBL3407912)Show InChI InChI=1S/C12H6F4N2O2/c13-8-2-1-6(3-7(8)12(14,15)16)9-4-10(11(19)20)18-5-17-9/h1-5H,(H,19,20) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072100
(CHEMBL3407882)Show InChI InChI=1S/C13H10Cl2N2O3/c1-20-5-8-11(16-6-17-12(8)13(18)19)7-2-3-9(14)10(15)4-7/h2-4,6H,5H2,1H3,(H,18,19) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072077
(CHEMBL3407866)Show InChI InChI=1S/C11H6Cl2N2O2/c12-7-2-1-6(3-8(7)13)9-4-10(11(16)17)15-5-14-9/h1-5H,(H,16,17) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO transfected in CHO cells assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072084
(CHEMBL3407930)Show SMILES COc1ccc(cc1OC)S(=O)(=O)Nc1ncc(s1)-c1cccc(c1)[N+]([O-])=O Show InChI InChI=1S/C17H15N3O6S2/c1-25-14-7-6-13(9-15(14)26-2)28(23,24)19-17-18-10-16(27-17)11-4-3-5-12(8-11)20(21)22/h3-10H,1-2H3,(H,18,19) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of KMO (unknown origin) |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072085
(CHEMBL3407867)Show InChI InChI=1S/C11H8N2O2/c14-11(15)10-6-9(12-7-13-10)8-4-2-1-3-5-8/h1-7H,(H,14,15) | PDB
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| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072125
(CHEMBL3407907)Show InChI InChI=1S/C11H6ClFN2O2/c12-6-1-2-7(8(13)3-6)9-4-10(11(16)17)15-5-14-9/h1-5H,(H,16,17) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072078
(CHEMBL3407905)Show InChI InChI=1S/C11H6F2N2O2/c12-7-2-1-6(3-8(7)13)9-4-10(11(16)17)15-5-14-9/h1-5H,(H,16,17) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO transfected in CHO cells assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072097
(CHEMBL3407879)Show InChI InChI=1S/C12H8Cl2N2O3/c1-19-11-9(15-5-16-10(11)12(17)18)6-2-3-7(13)8(14)4-6/h2-5H,1H3,(H,17,18) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072142
(CHEMBL3407923)Show InChI InChI=1S/C15H13ClN2O3/c16-11-5-10(3-4-14(11)21-7-9-1-2-9)12-6-13(15(19)20)18-8-17-12/h3-6,8-9H,1-2,7H2,(H,19,20) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072121
(CHEMBL3407902)Show InChI InChI=1S/C11H6ClFN2O2/c12-7-3-6(1-2-8(7)13)9-4-10(11(16)17)15-5-14-9/h1-5H,(H,16,17) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO transfected in CHO cells assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072178
(CHEMBL3407927)Show InChI InChI=1S/C16H15ClN2O3/c17-12-7-10(13-8-14(16(20)21)19-9-18-13)5-6-15(12)22-11-3-1-2-4-11/h5-9,11H,1-4H2,(H,20,21) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072132
(CHEMBL3407915)Show InChI InChI=1S/C12H9ClN2O3/c1-18-11-4-7(2-3-8(11)13)9-5-10(12(16)17)15-6-14-9/h2-6H,1H3,(H,16,17) | PDB
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| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072102
(CHEMBL3407884)Show InChI InChI=1S/C12H6Cl2N4O2/c13-7-2-1-6(3-8(7)14)9-4-10(16-5-15-9)11-17-12(19)20-18-11/h1-5H,(H,17,18,19) | PDB
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| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO transfected in CHO cells assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072078
(CHEMBL3407905)Show InChI InChI=1S/C11H6F2N2O2/c12-7-2-1-6(3-8(7)13)9-4-10(11(16)17)15-5-14-9/h1-5H,(H,16,17) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of KMO in human PBMC |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072178
(CHEMBL3407927)Show InChI InChI=1S/C16H15ClN2O3/c17-12-7-10(13-8-14(16(20)21)19-9-18-13)5-6-15(12)22-11-3-1-2-4-11/h5-9,11H,1-4H2,(H,20,21) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO transfected in CHO cells assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072077
(CHEMBL3407866)Show InChI InChI=1S/C11H6Cl2N2O2/c12-7-2-1-6(3-8(7)13)9-4-10(11(16)17)15-5-14-9/h1-5H,(H,16,17) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of KMO in human PBMC |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50072081
(CHEMBL3407922)Show InChI InChI=1S/C14H11ClN2O3/c15-10-5-8(1-4-13(10)20-9-2-3-9)11-6-12(14(18)19)17-7-16-11/h1,4-7,9H,2-3H2,(H,18,19) | PDB
Reactome pathway
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of KMO in rat microglia cells |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072103
(CHEMBL3407885)Show SMILES Clc1ccc(cc1Cl)-c1cc(ncn1)C(=O)NS(=O)(=O)c1ccccc1 Show InChI InChI=1S/C17H11Cl2N3O3S/c18-13-7-6-11(8-14(13)19)15-9-16(21-10-20-15)17(23)22-26(24,25)12-4-2-1-3-5-12/h1-10H,(H,22,23) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO transfected in CHO cells assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072124
(CHEMBL3407906)Show InChI InChI=1S/C11H6F2N2O2/c12-6-1-2-7(8(13)3-6)9-4-10(11(16)17)15-5-14-9/h1-5H,(H,16,17) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072081
(CHEMBL3407922)Show InChI InChI=1S/C14H11ClN2O3/c15-10-5-8(1-4-13(10)20-9-2-3-9)11-6-12(14(18)19)17-7-16-11/h1,4-7,9H,2-3H2,(H,18,19) | PDB
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| n/a | n/a | 82 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of KMO in human PBMC |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072134
(CHEMBL3407917)Show InChI InChI=1S/C17H18ClN3O4/c18-13-9-12(14-10-15(17(22)23)20-11-19-14)1-2-16(13)25-8-5-21-3-6-24-7-4-21/h1-2,9-11H,3-8H2,(H,22,23) | PDB
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| n/a | n/a | 83 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50072078
(CHEMBL3407905)Show InChI InChI=1S/C11H6F2N2O2/c12-7-2-1-6(3-8(7)13)9-4-10(11(16)17)15-5-14-9/h1-5H,(H,16,17) | PDB
Reactome pathway
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of KMO in rat microglia cells |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072093
(CHEMBL3407875)Show InChI InChI=1S/C12H7Cl2NO2/c13-9-2-1-7(5-10(9)14)11-6-8(12(16)17)3-4-15-11/h1-6H,(H,16,17) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50072079
(CHEMBL3407913)Show InChI InChI=1S/C12H9ClN2O2/c1-7-2-3-8(4-9(7)13)10-5-11(12(16)17)15-6-14-10/h2-6H,1H3,(H,16,17) | PDB
Reactome pathway
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of KMO in rat microglia cells |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50072077
(CHEMBL3407866)Show InChI InChI=1S/C11H6Cl2N2O2/c12-7-2-1-6(3-8(7)13)9-4-10(11(16)17)15-5-14-9/h1-5H,(H,16,17) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of KMO in rat microglia cells |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072080
(CHEMBL3407919)Show InChI InChI=1S/C12H6ClF3N2O3/c13-7-3-6(1-2-10(7)21-12(14,15)16)8-4-9(11(19)20)18-5-17-8/h1-5H,(H,19,20) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of KMO in human PBMC |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072126
(CHEMBL3407908)Show InChI InChI=1S/C12H6ClF3N2O2/c13-8-3-6(1-2-7(8)12(14,15)16)9-4-10(11(19)20)18-5-17-9/h1-5H,(H,19,20) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO transfected in CHO cells assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072096
(CHEMBL3407878)Show InChI InChI=1S/C11H6Cl2N2O3/c12-6-2-1-5(3-7(6)13)8-10(16)9(11(17)18)15-4-14-8/h1-4,16H,(H,17,18) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072079
(CHEMBL3407913)Show InChI InChI=1S/C12H9ClN2O2/c1-7-2-3-8(4-9(7)13)10-5-11(12(16)17)15-6-14-10/h2-6H,1H3,(H,16,17) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of KMO in human PBMC |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072092
(CHEMBL3407874)Show InChI InChI=1S/C12H7Cl2NO2/c13-9-2-1-7(5-10(9)14)8-3-4-15-11(6-8)12(16)17/h1-6H,(H,16,17) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO transfected in CHO cells assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50061915
(2-Amino-4-(3,4-dichloro-phenyl)-4-oxo-butyric acid...)Show InChI InChI=1S/C10H9Cl2NO3/c11-6-2-1-5(3-7(6)12)9(14)4-8(13)10(15)16/h1-3,8H,4,13H2,(H,15,16) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of rat KMO |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072118
(CHEMBL3407899)Show InChI InChI=1S/C11H7ClN2O2/c12-8-3-1-7(2-4-8)9-5-10(11(15)16)14-6-13-9/h1-6H,(H,15,16) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO transfected in CHO cells assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072101
(CHEMBL3407883)Show InChI InChI=1S/C11H6Cl2N6/c12-7-2-1-6(3-8(7)13)9-4-10(15-5-14-9)11-16-18-19-17-11/h1-5H,(H,16,17,18,19) | PDB
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| n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO transfected in CHO cells assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072099
(CHEMBL3407881)Show InChI InChI=1S/C11H7Cl2N3O2/c12-6-2-1-5(3-7(6)13)9-8(14)10(11(17)18)16-4-15-9/h1-4H,14H2,(H,17,18) | PDB
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| n/a | n/a | 260 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072142
(CHEMBL3407923)Show InChI InChI=1S/C15H13ClN2O3/c16-11-5-10(3-4-14(11)21-7-9-1-2-9)12-6-13(15(19)20)18-8-17-12/h3-6,8-9H,1-2,7H2,(H,19,20) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO transfected in CHO cells assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072104
(CHEMBL3407886)Show SMILES Clc1ccc(cc1Cl)-c1cc(NS(=O)(=O)c2ccccc2)ncn1 Show InChI InChI=1S/C16H11Cl2N3O2S/c17-13-7-6-11(8-14(13)18)15-9-16(20-10-19-15)21-24(22,23)12-4-2-1-3-5-12/h1-10H,(H,19,20,21) | PDB
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| n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072082
(CHEMBL3407865)Show InChI InChI=1S/C11H7ClN2O2/c12-8-3-1-2-7(4-8)9-5-10(11(15)16)14-6-13-9/h1-6H,(H,15,16) | PDB
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| n/a | n/a | 290 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO transfected in CHO cells assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072094
(CHEMBL3407876)Show InChI InChI=1S/C12H8Cl2N2O2/c1-6-15-10(5-11(16-6)12(17)18)7-2-3-8(13)9(14)4-7/h2-5H,1H3,(H,17,18) | PDB
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| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO transfected in CHO cells assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072123
(CHEMBL3407904)Show InChI InChI=1S/C11H6ClFN2O2/c12-7-3-1-2-6(10(7)13)8-4-9(11(16)17)15-5-14-8/h1-5H,(H,16,17) | PDB
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| n/a | n/a | 310 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO transfected in CHO cells assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072119
(CHEMBL3407900)Show InChI InChI=1S/C11H6Cl2N2O2/c12-7-1-6(2-8(13)3-7)9-4-10(11(16)17)15-5-14-9/h1-5H,(H,16,17) | PDB
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| n/a | n/a | 320 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO transfected in CHO cells assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072087
(CHEMBL3407869)Show InChI InChI=1S/C11H14N2O2/c14-11(15)10-6-9(12-7-13-10)8-4-2-1-3-5-8/h6-8H,1-5H2,(H,14,15) | PDB
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| n/a | n/a | 340 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072135
(CHEMBL3407918)Show InChI InChI=1S/C15H14ClN3O2/c16-11-7-10(3-4-14(11)19-5-1-2-6-19)12-8-13(15(20)21)18-9-17-12/h3-4,7-9H,1-2,5-6H2,(H,20,21) | PDB
Reactome pathway
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO transfected in CHO cells assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072131
(CHEMBL3407914)Show InChI InChI=1S/C12H9FN2O2/c1-7-2-3-8(4-9(7)13)10-5-11(12(16)17)15-6-14-10/h2-6H,1H3,(H,16,17) | PDB
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| n/a | n/a | 370 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO transfected in CHO cells assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072179
(CHEMBL3407928)Show InChI InChI=1S/C17H17ClN2O3/c18-13-8-11(14-9-15(17(21)22)20-10-19-14)6-7-16(13)23-12-4-2-1-3-5-12/h6-10,12H,1-5H2,(H,21,22) | PDB
Reactome pathway
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072175
(CHEMBL3407926)Show InChI InChI=1S/C14H11ClN2O4/c15-10-3-8(1-2-13(10)21-9-5-20-6-9)11-4-12(14(18)19)17-7-16-11/h1-4,7,9H,5-6H2,(H,18,19) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO transfected in CHO cells assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072135
(CHEMBL3407918)Show InChI InChI=1S/C15H14ClN3O2/c16-11-7-10(3-4-14(11)19-5-1-2-6-19)12-8-13(15(20)21)18-9-17-12/h3-4,7-9H,1-2,5-6H2,(H,20,21) | PDB
Reactome pathway
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072104
(CHEMBL3407886)Show SMILES Clc1ccc(cc1Cl)-c1cc(NS(=O)(=O)c2ccccc2)ncn1 Show InChI InChI=1S/C16H11Cl2N3O2S/c17-13-7-6-11(8-14(13)18)15-9-16(20-10-19-15)21-24(22,23)12-4-2-1-3-5-12/h1-10H,(H,19,20,21) | PDB
Reactome pathway
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO transfected in CHO cells assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072120
(CHEMBL3407901)Show InChI InChI=1S/C11H7FN2O2/c12-8-3-1-2-7(4-8)9-5-10(11(15)16)14-6-13-9/h1-6H,(H,15,16) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO transfected in CHO cells assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Mus musculus) | BDBM50061907
((+/-)-2-Amino-4-(3-nitro-phenyl)-4-oxo-butyric aci...)Show InChI InChI=1S/C10H10N2O5/c11-8(10(14)15)5-9(13)6-2-1-3-7(4-6)12(16)17/h1-4,8H,5,11H2,(H,14,15) | PDB
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| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of mouse KMO |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072086
(CHEMBL3407868)Show InChI InChI=1S/C10H7N3O2/c14-10(15)9-4-8(12-6-13-9)7-2-1-3-11-5-7/h1-6H,(H,14,15) | PDB
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| n/a | n/a | 990 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50072080
(CHEMBL3407919)Show InChI InChI=1S/C12H6ClF3N2O3/c13-7-3-6(1-2-10(7)21-12(14,15)16)8-4-9(11(19)20)18-5-17-8/h1-5H,(H,19,20) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of KMO in rat microglia cells |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072093
(CHEMBL3407875)Show InChI InChI=1S/C12H7Cl2NO2/c13-9-2-1-7(5-10(9)14)11-6-8(12(16)17)3-4-15-11/h1-6H,(H,16,17) | PDB
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| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO transfected in CHO cells assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072089
(CHEMBL3407871)Show InChI InChI=1S/C11H6Cl2N2O3/c12-7-2-1-6(3-8(7)13)18-10-4-9(11(16)17)14-5-15-10/h1-5H,(H,16,17) | PDB
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| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072098
(CHEMBL3407880)Show InChI InChI=1S/C12H8Cl2N2O2/c1-6-10(15-5-16-11(6)12(17)18)7-2-3-8(13)9(14)4-7/h2-5H,1H3,(H,17,18) | PDB
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| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO transfected in CHO cells assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072108
(CHEMBL3407890)Show InChI InChI=1S/C10H7Cl2N3/c11-7-2-1-6(3-8(7)12)9-4-10(13)15-5-14-9/h1-5H,(H2,13,14,15) | PDB
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| n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072125
(CHEMBL3407907)Show InChI InChI=1S/C11H6ClFN2O2/c12-6-1-2-7(8(13)3-6)9-4-10(11(16)17)15-5-14-9/h1-5H,(H,16,17) | PDB
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| n/a | n/a | 1.74E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO transfected in CHO cells assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072133
(CHEMBL3407916)Show InChI InChI=1S/C17H18ClN3O4/c18-13-2-1-12(14-10-15(17(22)23)20-11-19-14)9-16(13)25-8-5-21-3-6-24-7-4-21/h1-2,9-11H,3-8H2,(H,22,23) | PDB
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| n/a | n/a | 2.05E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072091
(CHEMBL3407873)Show InChI InChI=1S/C17H12N2O2/c20-17(21)16-10-15(18-11-19-16)14-8-4-7-13(9-14)12-5-2-1-3-6-12/h1-11H,(H,20,21) | PDB
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| n/a | n/a | 2.13E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072105
(CHEMBL3407887)Show InChI InChI=1S/C12H8Cl2N6/c1-20-12(17-18-19-20)11-5-10(15-6-16-11)7-2-3-8(13)9(14)4-7/h2-6H,1H3 | PDB
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| n/a | n/a | 2.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072096
(CHEMBL3407878)Show InChI InChI=1S/C11H6Cl2N2O3/c12-6-2-1-5(3-7(6)13)8-10(16)9(11(17)18)15-4-14-8/h1-4,16H,(H,17,18) | PDB
Reactome pathway
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| n/a | n/a | 3.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO transfected in CHO cells assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072107
(CHEMBL3407889)Show InChI InChI=1S/C11H5Cl2N3/c12-9-2-1-7(3-10(9)13)11-4-8(5-14)15-6-16-11/h1-4,6H | PDB
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| n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072134
(CHEMBL3407917)Show InChI InChI=1S/C17H18ClN3O4/c18-13-9-12(14-10-15(17(22)23)20-11-19-14)1-2-16(13)25-8-5-21-3-6-24-7-4-21/h1-2,9-11H,3-8H2,(H,22,23) | PDB
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| n/a | n/a | 4.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO transfected in CHO cells assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072100
(CHEMBL3407882)Show InChI InChI=1S/C13H10Cl2N2O3/c1-20-5-8-11(16-6-17-12(8)13(18)19)7-2-3-9(14)10(15)4-7/h2-4,6H,5H2,1H3,(H,18,19) | PDB
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| n/a | n/a | 4.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO transfected in CHO cells assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072097
(CHEMBL3407879)Show InChI InChI=1S/C12H8Cl2N2O3/c1-19-11-9(15-5-16-10(11)12(17)18)6-2-3-7(13)8(14)4-6/h2-5H,1H3,(H,17,18) | PDB
Reactome pathway
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| n/a | n/a | 4.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO transfected in CHO cells assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072112
(CHEMBL3407893)Show InChI InChI=1S/C12H6Cl2N4O/c13-8-2-1-7(3-9(8)14)10-4-11(16-5-15-10)12-17-6-19-18-12/h1-6H | PDB
Reactome pathway
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| n/a | n/a | 5.06E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072099
(CHEMBL3407881)Show InChI InChI=1S/C11H7Cl2N3O2/c12-6-2-1-5(3-7(6)13)9-8(14)10(11(17)18)16-4-15-9/h1-4H,14H2,(H,17,18) | PDB
Reactome pathway
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| n/a | n/a | 5.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO transfected in CHO cells assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072128
(CHEMBL3407910)Show InChI InChI=1S/C12H7F3N2O2/c13-12(14,15)8-4-2-1-3-7(8)9-5-10(11(18)19)17-6-16-9/h1-6H,(H,18,19) | PDB
Reactome pathway
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| n/a | n/a | 6.51E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072124
(CHEMBL3407906)Show InChI InChI=1S/C11H6F2N2O2/c12-6-1-2-7(8(13)3-6)9-4-10(11(16)17)15-5-14-9/h1-5H,(H,16,17) | PDB
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| n/a | n/a | 7.22E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO transfected in CHO cells assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072129
(CHEMBL3407911)Show InChI InChI=1S/C12H10N2O2/c1-8-3-2-4-9(5-8)10-6-11(12(15)16)14-7-13-10/h2-7H,1H3,(H,15,16) | PDB
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| n/a | n/a | 7.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO transfected in CHO cells assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072095
(CHEMBL3407877)Show InChI InChI=1S/C11H5Cl2FN2O2/c12-6-2-1-5(3-7(6)13)9-8(14)10(11(17)18)16-4-15-9/h1-4H,(H,17,18) | PDB
Reactome pathway
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| n/a | n/a | 9.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO transfected in CHO cells assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072090
(CHEMBL3407872)Show InChI InChI=1S/C11H7Cl2N3O2/c12-7-2-1-6(3-8(7)13)16-10-4-9(11(17)18)14-5-15-10/h1-5H,(H,17,18)(H,14,15,16) | PDB
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| n/a | n/a | 9.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072130
(CHEMBL3407912)Show InChI InChI=1S/C12H6F4N2O2/c13-8-2-1-6(3-7(8)12(14,15)16)9-4-10(11(19)20)18-5-17-9/h1-5H,(H,19,20) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO transfected in CHO cells assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072133
(CHEMBL3407916)Show InChI InChI=1S/C17H18ClN3O4/c18-13-2-1-12(14-10-15(17(22)23)20-11-19-14)9-16(13)25-8-5-21-3-6-24-7-4-21/h1-2,9-11H,3-8H2,(H,22,23) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO transfected in CHO cells assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072106
(CHEMBL3407888)Show InChI InChI=1S/C12H8Cl2N6/c1-20-18-12(17-19-20)11-5-10(15-6-16-11)7-2-3-8(13)9(14)4-7/h2-6H,1H3 | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072087
(CHEMBL3407869)Show InChI InChI=1S/C11H14N2O2/c14-11(15)10-6-9(12-7-13-10)8-4-2-1-3-5-8/h6-8H,1-5H2,(H,14,15) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO transfected in CHO cells assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072090
(CHEMBL3407872)Show InChI InChI=1S/C11H7Cl2N3O2/c12-7-2-1-6(3-8(7)13)16-10-4-9(11(17)18)14-5-15-10/h1-5H,(H,17,18)(H,14,15,16) | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO transfected in CHO cells assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072114
(CHEMBL3407895)Show InChI InChI=1S/C14H10Cl2N4O/c1-19-4-5-20(14(19)21)13-7-12(17-8-18-13)9-2-3-10(15)11(16)6-9/h2-8H,1H3 | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072086
(CHEMBL3407868)Show InChI InChI=1S/C10H7N3O2/c14-10(15)9-4-8(12-6-13-9)7-2-1-3-11-5-7/h1-6H,(H,14,15) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO transfected in CHO cells assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072085
(CHEMBL3407867)Show InChI InChI=1S/C11H8N2O2/c14-11(15)10-6-9(12-7-13-10)8-4-2-1-3-5-8/h1-7H,(H,14,15) | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO transfected in CHO cells assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072117
(CHEMBL3407898)Show InChI InChI=1S/C12H9Cl2N3O/c1-7(18)17-12-5-11(15-6-16-12)8-2-3-9(13)10(14)4-8/h2-6H,1H3,(H,15,16,17,18) | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072128
(CHEMBL3407910)Show InChI InChI=1S/C12H7F3N2O2/c13-12(14,15)8-4-2-1-3-7(8)9-5-10(11(18)19)17-6-16-9/h1-6H,(H,18,19) | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO transfected in CHO cells assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072111
(CHEMBL3407892)Show InChI InChI=1S/C13H8Cl2N4/c14-10-3-2-9(6-11(10)15)12-7-13(17-8-16-12)19-5-1-4-18-19/h1-8H | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072115
(CHEMBL3407896)Show InChI InChI=1S/C11H9Cl2N3O2S/c1-19(17,18)16-11-5-10(14-6-15-11)7-2-3-8(12)9(13)4-7/h2-6H,1H3,(H,14,15,16) | PDB
Reactome pathway
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072091
(CHEMBL3407873)Show InChI InChI=1S/C17H12N2O2/c20-17(21)16-10-15(18-11-19-16)14-8-4-7-13(9-14)12-5-2-1-3-6-12/h1-11H,(H,20,21) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO transfected in CHO cells assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072109
(CHEMBL3407891)Show InChI InChI=1S/C13H8Cl2N4/c14-10-2-1-9(5-11(10)15)12-6-13(18-7-17-12)19-4-3-16-8-19/h1-8H | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072088
(CHEMBL3407870)Show InChI InChI=1S/C9H11N3O3/c13-9(14)7-5-8(11-6-10-7)12-1-3-15-4-2-12/h5-6H,1-4H2,(H,13,14) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO transfected in CHO cells assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072113
(CHEMBL3407894)Show InChI InChI=1S/C13H8Cl2N4O/c14-9-2-1-8(5-10(9)15)11-6-12(18-7-17-11)19-4-3-16-13(19)20/h1-7H,(H,16,20) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072116
(CHEMBL3407897)Show InChI InChI=1S/C17H11Cl2N3O/c18-13-7-6-12(8-14(13)19)15-9-16(21-10-20-15)22-17(23)11-4-2-1-3-5-11/h1-10H,(H,20,21,22,23) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072127
(CHEMBL3407909)Show InChI InChI=1S/C12H7F3N2O2/c13-12(14,15)8-3-1-2-7(4-8)9-5-10(11(18)19)17-6-16-9/h1-6H,(H,18,19) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO transfected in CHO cells assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072132
(CHEMBL3407915)Show InChI InChI=1S/C12H9ClN2O3/c1-18-11-4-7(2-3-8(11)13)9-5-10(12(16)17)15-6-14-9/h2-6H,1H3,(H,16,17) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO transfected in CHO cells assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072089
(CHEMBL3407871)Show InChI InChI=1S/C11H6Cl2N2O3/c12-7-2-1-6(3-8(7)13)18-10-4-9(11(16)17)14-5-15-10/h1-5H,(H,16,17) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO transfected in CHO cells assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Homo sapiens (Human)) | BDBM50072088
(CHEMBL3407870)Show InChI InChI=1S/C9H11N3O3/c13-9(14)7-5-8(11-6-10-7)12-1-3-15-4-2-12/h5-6H,1-4H2,(H,13,14) | PDB
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Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this
Ligand-Target Pair | |
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