Found 87 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50166408
(CHEMBL3797756)Show SMILES OC[C@@H](NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1)c1cccc(Cl)c1 |r| Show InChI InChI=1S/C21H17ClN4O2/c22-16-3-1-2-14(10-16)19(12-27)24-21(28)15-4-5-18-17(11-15)20(26-25-18)13-6-8-23-9-7-13/h1-11,19,27H,12H2,(H,24,28)(H,25,26)/t19-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK2 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50166412
(CHEMBL3797917)Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NCc1c(Cl)cnc(Cl)c1Cl Show InChI InChI=1S/C20H14Cl3N5O/c1-10-6-11(4-5-24-10)18-13-7-12(2-3-16(13)27-28-18)20(29)26-8-14-15(21)9-25-19(23)17(14)22/h2-7,9H,8H2,1H3,(H,26,29)(H,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK2 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50166567
(CHEMBL3797242)Show SMILES Clc1cncc(Cl)c1CNC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 Show InChI InChI=1S/C19H13Cl2N5O/c20-15-9-23-10-16(21)14(15)8-24-19(27)12-1-2-17-13(7-12)18(26-25-17)11-3-5-22-6-4-11/h1-7,9-10H,8H2,(H,24,27)(H,25,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 9.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK2 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50166572
(CHEMBL3798624)Show SMILES C[C@H](NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1)c1c(Cl)cccc1Cl |r| Show InChI InChI=1S/C22H18Cl2N4O/c1-12-10-14(8-9-25-12)21-16-11-15(6-7-19(16)27-28-21)22(29)26-13(2)20-17(23)4-3-5-18(20)24/h3-11,13H,1-2H3,(H,26,29)(H,27,28)/t13-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK2 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50166411
(CHEMBL3799113)Show SMILES Fc1c(Cl)ccc(CNC(=O)c2ccc3[nH]nc(-c4ccncc4)c3c2)c1Cl Show InChI InChI=1S/C20H13Cl2FN4O/c21-15-3-1-13(17(22)18(15)23)10-25-20(28)12-2-4-16-14(9-12)19(27-26-16)11-5-7-24-8-6-11/h1-9H,10H2,(H,25,28)(H,26,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK2 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50166349
(CHEMBL3799716)Show SMILES Clc1cccc(CNC(=O)c2ccc3[nH]nc(-c4ccncc4)c3c2)c1 Show InChI InChI=1S/C42H44N6O6/c43-35(23-29-11-19-33(49)20-12-29)39(51)47-37(25-27-7-3-1-4-8-27)41(53)45-31-15-17-32(18-16-31)46-42(54)38(26-28-9-5-2-6-10-28)48-40(52)36(44)24-30-13-21-34(50)22-14-30/h1-22,35-38,49-50H,23-26,43-44H2,(H,45,53)(H,46,54)(H,47,51)(H,48,52)/t35-,36-,37-,38-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK2 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50166413
(CHEMBL3799117)Show SMILES CC(NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1)c1c(Cl)cnc(Cl)c1Cl Show InChI InChI=1S/C21H16Cl3N5O/c1-10-7-12(5-6-25-10)19-14-8-13(3-4-16(14)28-29-19)21(30)27-11(2)17-15(22)9-26-20(24)18(17)23/h3-9,11H,1-2H3,(H,27,30)(H,28,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK2 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50166415
(CHEMBL3799819)Show SMILES CC(C)Nc1cc(-c2c[nH]c(c2)C(=O)N[C@H](CO)c2ccccc2)c(Cl)cn1 |r| Show InChI InChI=1S/C21H23ClN4O2/c1-13(2)25-20-9-16(17(22)11-24-20)15-8-18(23-10-15)21(28)26-19(12-27)14-6-4-3-5-7-14/h3-11,13,19,23,27H,12H2,1-2H3,(H,24,25)(H,26,28)/t19-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK2 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50166429
(CHEMBL3797827)Show SMILES Nc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC(CO)c1cccc(Cl)c1 Show InChI InChI=1S/C21H18ClN5O2/c22-15-3-1-2-12(8-15)18(11-28)25-21(29)14-4-5-17-16(9-14)20(27-26-17)13-6-7-24-19(23)10-13/h1-10,18,28H,11H2,(H2,23,24)(H,25,29)(H,26,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK2 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50166569
(CHEMBL3798257)Show SMILES CC(NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1)c1c(Cl)cncc1Cl Show InChI InChI=1S/C21H17Cl2N5O/c1-11-7-13(5-6-25-11)20-15-8-14(3-4-18(15)27-28-20)21(29)26-12(2)19-16(22)9-24-10-17(19)23/h3-10,12H,1-2H3,(H,26,29)(H,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK2 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50166409
(CHEMBL3797587)Show SMILES CC(NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1)c1ccccc1Cl Show InChI InChI=1S/C21H17ClN4O/c1-13(16-4-2-3-5-18(16)22)24-21(27)15-6-7-19-17(12-15)20(26-25-19)14-8-10-23-11-9-14/h2-13H,1H3,(H,24,27)(H,25,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK2 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 3
(Homo sapiens (Human)) | BDBM50166412
(CHEMBL3797917)Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NCc1c(Cl)cnc(Cl)c1Cl Show InChI InChI=1S/C20H14Cl3N5O/c1-10-6-11(4-5-24-10)18-13-7-12(2-3-16(13)27-28-18)20(29)26-8-14-15(21)9-25-19(23)17(14)22/h2-7,9H,8H2,1H3,(H,26,29)(H,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK1 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50166427
(CHEMBL3798015)Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC(CO)c1cccc(Cl)c1 Show InChI InChI=1S/C22H19ClN4O2/c1-13-9-15(7-8-24-13)21-18-11-16(5-6-19(18)26-27-21)22(29)25-20(12-28)14-3-2-4-17(23)10-14/h2-11,20,28H,12H2,1H3,(H,25,29)(H,26,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK2 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50166324
(CHEMBL3798163)Show SMILES O=C(NCCc1ccccc1)c1ccc2[nH]nc(-c3ccncc3)c2c1 Show InChI InChI=1S/C21H18N4O/c26-21(23-13-8-15-4-2-1-3-5-15)17-6-7-19-18(14-17)20(25-24-19)16-9-11-22-12-10-16/h1-7,9-12,14H,8,13H2,(H,23,26)(H,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK2 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 3
(Homo sapiens (Human)) | BDBM50166572
(CHEMBL3798624)Show SMILES C[C@H](NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1)c1c(Cl)cccc1Cl |r| Show InChI InChI=1S/C22H18Cl2N4O/c1-12-10-14(8-9-25-12)21-16-11-15(6-7-19(16)27-28-21)22(29)26-13(2)20-17(23)4-3-5-18(20)24/h3-11,13H,1-2H3,(H,26,29)(H,27,28)/t13-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK1 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50166430
(CHEMBL3798692)Show SMILES CC(NC(=O)c1ccc2[nH]nc(-c3cc(F)c(O)c(F)c3)c2c1)c1cccc(Cl)c1 Show InChI InChI=1S/C22H16ClF2N3O2/c1-11(12-3-2-4-15(23)7-12)26-22(30)13-5-6-19-16(8-13)20(28-27-19)14-9-17(24)21(29)18(25)10-14/h2-11,29H,1H3,(H,26,30)(H,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK2 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 3
(Homo sapiens (Human)) | BDBM50166413
(CHEMBL3799117)Show SMILES CC(NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1)c1c(Cl)cnc(Cl)c1Cl Show InChI InChI=1S/C21H16Cl3N5O/c1-10-7-12(5-6-25-10)19-14-8-13(3-4-16(14)28-29-19)21(30)27-11(2)17-15(22)9-26-20(24)18(17)23/h3-9,11H,1-2H3,(H,27,30)(H,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK1 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50166568
(CHEMBL3799614)Show SMILES Clc1cc(CNC(=O)c2ccc3[nH]nc(-c4ccncc4)c3c2)ccn1 Show InChI InChI=1S/C19H14ClN5O/c20-17-9-12(3-8-22-17)11-23-19(26)14-1-2-16-15(10-14)18(25-24-16)13-4-6-21-7-5-13/h1-10H,11H2,(H,23,26)(H,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK2 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50166424
(CHEMBL3800134)Show SMILES OCC(NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1)c1cccc(Cl)c1 Show InChI InChI=1S/C21H17ClN4O2/c22-16-3-1-2-14(10-16)19(12-27)24-21(28)15-4-5-18-17(11-15)20(26-25-18)13-6-8-23-9-7-13/h1-11,19,27H,12H2,(H,24,28)(H,25,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK2 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50166419
(CHEMBL3797667)Show SMILES C[C@@H](NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1)c1cccc(Cl)c1 |r| Show InChI InChI=1S/C21H17ClN4O/c1-13(15-3-2-4-17(22)11-15)24-21(27)16-5-6-19-18(12-16)20(26-25-19)14-7-9-23-10-8-14/h2-13H,1H3,(H,24,27)(H,25,26)/t13-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK2 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 3
(Homo sapiens (Human)) | BDBM50166408
(CHEMBL3797756)Show SMILES OC[C@@H](NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1)c1cccc(Cl)c1 |r| Show InChI InChI=1S/C21H17ClN4O2/c22-16-3-1-2-14(10-16)19(12-27)24-21(28)15-4-5-18-17(11-15)20(26-25-18)13-6-8-23-9-7-13/h1-11,19,27H,12H2,(H,24,28)(H,25,26)/t19-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK1 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 3
(Homo sapiens (Human)) | BDBM50166568
(CHEMBL3799614)Show SMILES Clc1cc(CNC(=O)c2ccc3[nH]nc(-c4ccncc4)c3c2)ccn1 Show InChI InChI=1S/C19H14ClN5O/c20-17-9-12(3-8-22-17)11-23-19(26)14-1-2-16-15(10-14)18(25-24-16)13-4-6-21-7-5-13/h1-10H,11H2,(H,23,26)(H,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK1 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 3
(Homo sapiens (Human)) | BDBM50166569
(CHEMBL3798257)Show SMILES CC(NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1)c1c(Cl)cncc1Cl Show InChI InChI=1S/C21H17Cl2N5O/c1-11-7-13(5-6-25-11)20-15-8-14(3-4-18(15)27-28-20)21(29)26-12(2)19-16(22)9-24-10-17(19)23/h3-10,12H,1-2H3,(H,26,29)(H,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK1 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 3
(Homo sapiens (Human)) | BDBM50166411
(CHEMBL3799113)Show SMILES Fc1c(Cl)ccc(CNC(=O)c2ccc3[nH]nc(-c4ccncc4)c3c2)c1Cl Show InChI InChI=1S/C20H13Cl2FN4O/c21-15-3-1-13(17(22)18(15)23)10-25-20(28)12-2-4-16-14(9-12)19(27-26-16)11-5-7-24-8-6-11/h1-9H,10H2,(H,25,28)(H,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK1 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50166410
(CHEMBL3800263)Show SMILES Clc1ccccc1CNC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 Show InChI InChI=1S/C20H15ClN4O/c21-17-4-2-1-3-15(17)12-23-20(26)14-5-6-18-16(11-14)19(25-24-18)13-7-9-22-10-8-13/h1-11H,12H2,(H,23,26)(H,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK2 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 3
(Homo sapiens (Human)) | BDBM50166430
(CHEMBL3798692)Show SMILES CC(NC(=O)c1ccc2[nH]nc(-c3cc(F)c(O)c(F)c3)c2c1)c1cccc(Cl)c1 Show InChI InChI=1S/C22H16ClF2N3O2/c1-11(12-3-2-4-15(23)7-12)26-22(30)13-5-6-19-16(8-13)20(28-27-19)14-9-17(24)21(29)18(25)10-14/h2-11,29H,1H3,(H,26,30)(H,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK1 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50166428
(CHEMBL3799983)Show SMILES OCC(NC(=O)c1ccc2[nH]nc(-c3ccc(O)c(F)c3)c2c1)c1cccc(Cl)c1 Show InChI InChI=1S/C22H17ClFN3O3/c23-15-3-1-2-12(8-15)19(11-28)25-22(30)14-4-6-18-16(9-14)21(27-26-18)13-5-7-20(29)17(24)10-13/h1-10,19,28-29H,11H2,(H,25,30)(H,26,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK2 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50166290
(CHEMBL3798926)Show SMILES O=C(NCCCc1ccccc1)c1ccc2[nH]nc(-c3ccncc3)c2c1 Show InChI InChI=1S/C22H20N4O/c27-22(24-12-4-7-16-5-2-1-3-6-16)18-8-9-20-19(15-18)21(26-25-20)17-10-13-23-14-11-17/h1-3,5-6,8-11,13-15H,4,7,12H2,(H,24,27)(H,25,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK2 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 3
(Homo sapiens (Human)) | BDBM50166409
(CHEMBL3797587)Show SMILES CC(NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1)c1ccccc1Cl Show InChI InChI=1S/C21H17ClN4O/c1-13(16-4-2-3-5-18(16)22)24-21(27)15-6-7-19-17(12-15)20(26-25-19)14-8-10-23-11-9-14/h2-13H,1H3,(H,24,27)(H,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK1 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 3
(Homo sapiens (Human)) | BDBM50166324
(CHEMBL3798163)Show SMILES O=C(NCCc1ccccc1)c1ccc2[nH]nc(-c3ccncc3)c2c1 Show InChI InChI=1S/C21H18N4O/c26-21(23-13-8-15-4-2-1-3-5-15)17-6-7-19-18(14-17)20(25-24-19)16-9-11-22-12-10-16/h1-7,9-12,14H,8,13H2,(H,23,26)(H,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK1 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50166322
(CHEMBL3797548)Show SMILES CC(CNC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1)Oc1ccccc1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK2 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 3
(Homo sapiens (Human)) | BDBM50166290
(CHEMBL3798926)Show SMILES O=C(NCCCc1ccccc1)c1ccc2[nH]nc(-c3ccncc3)c2c1 Show InChI InChI=1S/C22H20N4O/c27-22(24-12-4-7-16-5-2-1-3-6-16)18-8-9-20-19(15-18)21(26-25-20)17-10-13-23-14-11-17/h1-3,5-6,8-11,13-15H,4,7,12H2,(H,24,27)(H,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK1 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 3
(Homo sapiens (Human)) | BDBM50166410
(CHEMBL3800263)Show SMILES Clc1ccccc1CNC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 Show InChI InChI=1S/C20H15ClN4O/c21-17-4-2-1-3-15(17)12-23-20(26)14-5-6-18-16(11-14)19(25-24-18)13-7-9-22-10-8-13/h1-11H,12H2,(H,23,26)(H,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 46 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK1 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50166331
(CHEMBL3798109)Show InChI InChI=1S/C20H16N4O/c25-20(22-13-14-4-2-1-3-5-14)16-6-7-18-17(12-16)19(24-23-18)15-8-10-21-11-9-15/h1-12H,13H2,(H,22,25)(H,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 51 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK2 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50166350
(CHEMBL3798631)Show SMILES CC(NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1)c1cccc(Cl)c1 Show InChI InChI=1S/C21H17ClN4O/c1-13(15-3-2-4-17(22)11-15)24-21(27)16-5-6-19-18(12-16)20(26-25-19)14-7-9-23-10-8-14/h2-13H,1H3,(H,24,27)(H,25,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK2 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 3
(Homo sapiens (Human)) | BDBM50166427
(CHEMBL3798015)Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC(CO)c1cccc(Cl)c1 Show InChI InChI=1S/C22H19ClN4O2/c1-13-9-15(7-8-24-13)21-18-11-16(5-6-19(18)26-27-21)22(29)25-20(12-28)14-3-2-4-17(23)10-14/h2-11,20,28H,12H2,1H3,(H,25,29)(H,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK1 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 3
(Homo sapiens (Human)) | BDBM50166567
(CHEMBL3797242)Show SMILES Clc1cncc(Cl)c1CNC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 Show InChI InChI=1S/C19H13Cl2N5O/c20-15-9-23-10-16(21)14(15)8-24-19(27)12-1-2-17-13(7-12)18(26-25-17)11-3-5-22-6-4-11/h1-7,9-10H,8H2,(H,24,27)(H,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK1 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50166352
(CHEMBL3800189)Show SMILES CCC(NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1)c1cccc(Cl)c1 Show InChI InChI=1S/C42H44N6O6/c43-33(23-29-15-19-31(49)20-16-29)39(51)47-37(25-27-9-3-1-4-10-27)41(53)45-35-13-7-8-14-36(35)46-42(54)38(26-28-11-5-2-6-12-28)48-40(52)34(44)24-30-17-21-32(50)22-18-30/h1-22,33-34,37-38,49-50H,23-26,43-44H2,(H,45,53)(H,46,54)(H,47,51)(H,48,52)/t33-,34-,37-,38-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 59 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK2 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50166422
(CHEMBL3797246)Show SMILES OCC(NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1)c1cc(Cl)cc(Cl)c1 Show InChI InChI=1S/C21H16Cl2N4O2/c22-15-7-14(8-16(23)10-15)19(11-28)25-21(29)13-1-2-18-17(9-13)20(27-26-18)12-3-5-24-6-4-12/h1-10,19,28H,11H2,(H,25,29)(H,26,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 61 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK2 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50166414
(CHEMBL3798604)Show SMILES O=C(NCCOc1ccccc1)c1ccc2[nH]nc(-c3ccncc3)c2c1 Show InChI InChI=1S/C21H18N4O2/c26-21(23-12-13-27-17-4-2-1-3-5-17)16-6-7-19-18(14-16)20(25-24-19)15-8-10-22-11-9-15/h1-11,14H,12-13H2,(H,23,26)(H,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK2 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 3
(Homo sapiens (Human)) | BDBM50166429
(CHEMBL3797827)Show SMILES Nc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC(CO)c1cccc(Cl)c1 Show InChI InChI=1S/C21H18ClN5O2/c22-15-3-1-2-12(8-15)18(11-28)25-21(29)14-4-5-17-16(9-14)20(27-26-17)13-6-7-24-19(23)10-13/h1-10,18,28H,11H2,(H2,23,24)(H,25,29)(H,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 67 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK1 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 3
(Homo sapiens (Human)) | BDBM50166424
(CHEMBL3800134)Show SMILES OCC(NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1)c1cccc(Cl)c1 Show InChI InChI=1S/C21H17ClN4O2/c22-16-3-1-2-14(10-16)19(12-27)24-21(28)15-4-5-18-17(11-15)20(26-25-18)13-6-8-23-9-7-13/h1-11,19,27H,12H2,(H,24,28)(H,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 72 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK1 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 3
(Homo sapiens (Human)) | BDBM50166349
(CHEMBL3799716)Show SMILES Clc1cccc(CNC(=O)c2ccc3[nH]nc(-c4ccncc4)c3c2)c1 Show InChI InChI=1S/C42H44N6O6/c43-35(23-29-11-19-33(49)20-12-29)39(51)47-37(25-27-7-3-1-4-8-27)41(53)45-31-15-17-32(18-16-31)46-42(54)38(26-28-9-5-2-6-10-28)48-40(52)36(44)24-30-13-21-34(50)22-14-30/h1-22,35-38,49-50H,23-26,43-44H2,(H,45,53)(H,46,54)(H,47,51)(H,48,52)/t35-,36-,37-,38-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 74 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK1 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 3
(Homo sapiens (Human)) | BDBM50166352
(CHEMBL3800189)Show SMILES CCC(NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1)c1cccc(Cl)c1 Show InChI InChI=1S/C42H44N6O6/c43-33(23-29-15-19-31(49)20-16-29)39(51)47-37(25-27-9-3-1-4-10-27)41(53)45-35-13-7-8-14-36(35)46-42(54)38(26-28-11-5-2-6-12-28)48-40(52)34(44)24-30-17-21-32(50)22-18-30/h1-22,33-34,37-38,49-50H,23-26,43-44H2,(H,45,53)(H,46,54)(H,47,51)(H,48,52)/t33-,34-,37-,38-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 79 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK1 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50166417
(CHEMBL3799370)Show SMILES CC(CNC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1)OCc1ccccc1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 89 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK2 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 3
(Homo sapiens (Human)) | BDBM50166331
(CHEMBL3798109)Show InChI InChI=1S/C20H16N4O/c25-20(22-13-14-4-2-1-3-5-14)16-6-7-18-17(12-16)19(24-23-18)15-8-10-21-11-9-15/h1-12H,13H2,(H,22,25)(H,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 106 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK1 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50166566
(CHEMBL3797371)Show SMILES CC(NC(=O)c1ccc2[nH]nc(-c3cc(C)nc(C)c3)c2c1)c1cccc(Cl)c1 Show InChI InChI=1S/C23H21ClN4O/c1-13-9-18(10-14(2)25-13)22-20-12-17(7-8-21(20)27-28-22)23(29)26-15(3)16-5-4-6-19(24)11-16/h4-12,15H,1-3H3,(H,26,29)(H,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK2 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 3
(Homo sapiens (Human)) | BDBM50166428
(CHEMBL3799983)Show SMILES OCC(NC(=O)c1ccc2[nH]nc(-c3ccc(O)c(F)c3)c2c1)c1cccc(Cl)c1 Show InChI InChI=1S/C22H17ClFN3O3/c23-15-3-1-2-12(8-15)19(11-28)25-22(30)14-4-6-18-16(9-14)21(27-26-18)13-5-7-20(29)17(24)10-13/h1-10,19,28-29H,11H2,(H,25,30)(H,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 111 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK1 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 3
(Homo sapiens (Human)) | BDBM50166322
(CHEMBL3797548)Show SMILES CC(CNC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1)Oc1ccccc1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 128 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK1 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50166416
(CHEMBL3799228)Show SMILES O=C(NCCNc1ccccc1)c1ccc2[nH]nc(-c3ccncc3)c2c1 Show InChI InChI=1S/C21H19N5O/c27-21(24-13-12-23-17-4-2-1-3-5-17)16-6-7-19-18(14-16)20(26-25-19)15-8-10-22-11-9-15/h1-11,14,23H,12-13H2,(H,24,27)(H,25,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK2 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50166423
(CHEMBL3797696)Show SMILES Clc1cccc(Cl)c1CNC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 Show InChI InChI=1S/C20H14Cl2N4O/c21-16-2-1-3-17(22)15(16)11-24-20(27)13-4-5-18-14(10-13)19(26-25-18)12-6-8-23-9-7-12/h1-10H,11H2,(H,24,27)(H,25,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 154 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK2 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 3
(Homo sapiens (Human)) | BDBM50166350
(CHEMBL3798631)Show SMILES CC(NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1)c1cccc(Cl)c1 Show InChI InChI=1S/C21H17ClN4O/c1-13(15-3-2-4-17(22)11-15)24-21(27)16-5-6-19-18(12-16)20(26-25-19)14-7-9-23-10-8-14/h2-13H,1H3,(H,24,27)(H,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 154 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK1 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50166353
(CHEMBL3799725)Show SMILES OC[C@H](NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1)c1cccc(Cl)c1 |r| Show InChI InChI=1S/C40H46N6O6/c41-33(23-29-11-15-31(47)16-12-29)37(49)43-35(25-27-7-3-1-4-8-27)39(51)45-19-21-46(22-20-45)40(52)36(26-28-9-5-2-6-10-28)44-38(50)34(42)24-30-13-17-32(48)18-14-30/h1-18,33-36,47-48H,19-26,41-42H2,(H,43,49)(H,44,50)/t33-,34-,35-,36-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 219 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK2 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50166573
(CHEMBL3798526)Show SMILES CC(NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1)c1ccncc1 Show InChI InChI=1S/C21H19N5O/c1-13-11-16(7-10-23-13)20-18-12-17(3-4-19(18)25-26-20)21(27)24-14(2)15-5-8-22-9-6-15/h3-12,14H,1-2H3,(H,24,27)(H,25,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 226 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK2 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50166425
(CHEMBL3799663)Show SMILES OCC(NC(=O)c1ccc2[nH]nc(-c3ccccc3)c2c1)c1cccc(Cl)c1 Show InChI InChI=1S/C22H18ClN3O2/c23-17-8-4-7-15(11-17)20(13-27)24-22(28)16-9-10-19-18(12-16)21(26-25-19)14-5-2-1-3-6-14/h1-12,20,27H,13H2,(H,24,28)(H,25,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 276 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK2 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50166426
(CHEMBL3798700)Show SMILES OCC(NC(=O)c1ccc2[nH]nc(C3CCOCC3)c2c1)c1cccc(Cl)c1 Show InChI InChI=1S/C21H22ClN3O3/c22-16-3-1-2-14(10-16)19(12-26)23-21(27)15-4-5-18-17(11-15)20(25-24-18)13-6-8-28-9-7-13/h1-5,10-11,13,19,26H,6-9,12H2,(H,23,27)(H,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 297 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK2 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50166418
(CHEMBL3799863)Show SMILES Clc1cccc(CCNC(=O)c2ccc3[nH]nc(-c4ccncc4)c3c2)c1 Show InChI InChI=1S/C21H17ClN4O/c22-17-3-1-2-14(12-17)6-11-24-21(27)16-4-5-19-18(13-16)20(26-25-19)15-7-9-23-10-8-15/h1-5,7-10,12-13H,6,11H2,(H,24,27)(H,25,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 425 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK2 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50166420
(CHEMBL3798137)Show SMILES C[C@H](NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1)c1cccc(Cl)c1 |r| Show InChI InChI=1S/C21H17ClN4O/c1-13(15-3-2-4-17(22)11-15)24-21(27)16-5-6-19-18(12-16)20(26-25-19)14-7-9-23-10-8-14/h2-13H,1H3,(H,24,27)(H,25,26)/t13-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 469 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK2 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50166570
(CHEMBL3798401)Show SMILES C[C@@H](NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1)c1c(Cl)cccc1Cl |r| Show InChI InChI=1S/C22H18Cl2N4O/c1-12-10-14(8-9-25-12)21-16-11-15(6-7-19(16)27-28-21)22(29)26-13(2)20-17(23)4-3-5-18(20)24/h3-11,13H,1-2H3,(H,26,29)(H,27,28)/t13-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 632 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK2 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 3
(Homo sapiens (Human)) | BDBM50166353
(CHEMBL3799725)Show SMILES OC[C@H](NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1)c1cccc(Cl)c1 |r| Show InChI InChI=1S/C40H46N6O6/c41-33(23-29-11-15-31(47)16-12-29)37(49)43-35(25-27-7-3-1-4-8-27)39(51)45-19-21-46(22-20-45)40(52)36(26-28-9-5-2-6-10-28)44-38(50)34(42)24-30-13-17-32(48)18-14-30/h1-18,33-36,47-48H,19-26,41-42H2,(H,43,49)(H,44,50)/t33-,34-,35-,36-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 833 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK1 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50166350
(CHEMBL3798631)Show SMILES CC(NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1)c1cccc(Cl)c1 Show InChI InChI=1S/C21H17ClN4O/c1-13(15-3-2-4-17(22)11-15)24-21(27)16-5-6-19-18(12-16)20(26-25-19)14-7-9-23-10-8-14/h2-13H,1H3,(H,24,27)(H,25,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of PDGFRbeta (unknown origin) by Z-LYTE assay |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50166569
(CHEMBL3798257)Show SMILES CC(NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1)c1c(Cl)cncc1Cl Show InChI InChI=1S/C21H17Cl2N5O/c1-11-7-13(5-6-25-11)20-15-8-14(3-4-18(15)27-28-20)21(29)26-12(2)19-16(22)9-24-10-17(19)23/h3-10,12H,1-2H3,(H,26,29)(H,27,28) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of c-Src (unknown origin) by Z-LYTE assay |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50166350
(CHEMBL3798631)Show SMILES CC(NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1)c1cccc(Cl)c1 Show InChI InChI=1S/C21H17ClN4O/c1-13(15-3-2-4-17(22)11-15)24-21(27)16-5-6-19-18(12-16)20(26-25-19)14-7-9-23-10-8-14/h2-13H,1H3,(H,24,27)(H,25,26) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of EGFR (unknown origin) by Z-LYTE assay |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50166350
(CHEMBL3798631)Show SMILES CC(NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1)c1cccc(Cl)c1 Show InChI InChI=1S/C21H17ClN4O/c1-13(15-3-2-4-17(22)11-15)24-21(27)16-5-6-19-18(12-16)20(26-25-19)14-7-9-23-10-8-14/h2-13H,1H3,(H,24,27)(H,25,26) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of FLT1 (unknown origin) by Z-LYTE assay |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50166350
(CHEMBL3798631)Show SMILES CC(NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1)c1cccc(Cl)c1 Show InChI InChI=1S/C21H17ClN4O/c1-13(15-3-2-4-17(22)11-15)24-21(27)16-5-6-19-18(12-16)20(26-25-19)14-7-9-23-10-8-14/h2-13H,1H3,(H,24,27)(H,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R (unknown origin) by Z-LYTE assay |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50166569
(CHEMBL3798257)Show SMILES CC(NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1)c1c(Cl)cncc1Cl Show InChI InChI=1S/C21H17Cl2N5O/c1-11-7-13(5-6-25-11)20-15-8-14(3-4-18(15)27-28-20)21(29)26-12(2)19-16(22)9-24-10-17(19)23/h3-10,12H,1-2H3,(H,26,29)(H,27,28) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of c-MET (unknown origin) by Z-LYTE assay |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM50166350
(CHEMBL3798631)Show SMILES CC(NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1)c1cccc(Cl)c1 Show InChI InChI=1S/C21H17ClN4O/c1-13(15-3-2-4-17(22)11-15)24-21(27)16-5-6-19-18(12-16)20(26-25-19)14-7-9-23-10-8-14/h2-13H,1H3,(H,24,27)(H,25,26) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of RET (unknown origin) by Z-LYTE assay |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
ALK tyrosine kinase receptor
(Homo sapiens (Human)) | BDBM50166350
(CHEMBL3798631)Show SMILES CC(NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1)c1cccc(Cl)c1 Show InChI InChI=1S/C21H17ClN4O/c1-13(15-3-2-4-17(22)11-15)24-21(27)16-5-6-19-18(12-16)20(26-25-19)14-7-9-23-10-8-14/h2-13H,1H3,(H,24,27)(H,25,26) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of ALK (unknown origin) by Z-LYTE assay |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50166350
(CHEMBL3798631)Show SMILES CC(NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1)c1cccc(Cl)c1 Show InChI InChI=1S/C21H17ClN4O/c1-13(15-3-2-4-17(22)11-15)24-21(27)16-5-6-19-18(12-16)20(26-25-19)14-7-9-23-10-8-14/h2-13H,1H3,(H,24,27)(H,25,26) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of c-MET (unknown origin) by Z-LYTE assay |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50166350
(CHEMBL3798631)Show SMILES CC(NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1)c1cccc(Cl)c1 Show InChI InChI=1S/C21H17ClN4O/c1-13(15-3-2-4-17(22)11-15)24-21(27)16-5-6-19-18(12-16)20(26-25-19)14-7-9-23-10-8-14/h2-13H,1H3,(H,24,27)(H,25,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of FGFR1 (unknown origin) by Z-LYTE assay |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Receptor tyrosine-protein kinase erbB-2
(Homo sapiens (Human)) | BDBM50166569
(CHEMBL3798257)Show SMILES CC(NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1)c1c(Cl)cncc1Cl Show InChI InChI=1S/C21H17Cl2N5O/c1-11-7-13(5-6-25-11)20-15-8-14(3-4-18(15)27-28-20)21(29)26-12(2)19-16(22)9-24-10-17(19)23/h3-10,12H,1-2H3,(H,26,29)(H,27,28) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of ERBB2 (unknown origin) by Z-LYTE assay |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50166569
(CHEMBL3798257)Show SMILES CC(NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1)c1c(Cl)cncc1Cl Show InChI InChI=1S/C21H17Cl2N5O/c1-11-7-13(5-6-25-11)20-15-8-14(3-4-18(15)27-28-20)21(29)26-12(2)19-16(22)9-24-10-17(19)23/h3-10,12H,1-2H3,(H,26,29)(H,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R (unknown origin) by Z-LYTE assay |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase ABL1
(Homo sapiens (Human)) | BDBM50166569
(CHEMBL3798257)Show SMILES CC(NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1)c1c(Cl)cncc1Cl Show InChI InChI=1S/C21H17Cl2N5O/c1-11-7-13(5-6-25-11)20-15-8-14(3-4-18(15)27-28-20)21(29)26-12(2)19-16(22)9-24-10-17(19)23/h3-10,12H,1-2H3,(H,26,29)(H,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of ABL (unknown origin) by Z-LYTE assay |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Receptor tyrosine-protein kinase erbB-2
(Homo sapiens (Human)) | BDBM50166350
(CHEMBL3798631)Show SMILES CC(NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1)c1cccc(Cl)c1 Show InChI InChI=1S/C21H17ClN4O/c1-13(15-3-2-4-17(22)11-15)24-21(27)16-5-6-19-18(12-16)20(26-25-19)14-7-9-23-10-8-14/h2-13H,1H3,(H,24,27)(H,25,26) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of ERBB2 (unknown origin) by Z-LYTE assay |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
ALK tyrosine kinase receptor
(Homo sapiens (Human)) | BDBM50166569
(CHEMBL3798257)Show SMILES CC(NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1)c1c(Cl)cncc1Cl Show InChI InChI=1S/C21H17Cl2N5O/c1-11-7-13(5-6-25-11)20-15-8-14(3-4-18(15)27-28-20)21(29)26-12(2)19-16(22)9-24-10-17(19)23/h3-10,12H,1-2H3,(H,26,29)(H,27,28) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of ALK (unknown origin) by Z-LYTE assay |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase ABL1
(Homo sapiens (Human)) | BDBM50166350
(CHEMBL3798631)Show SMILES CC(NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1)c1cccc(Cl)c1 Show InChI InChI=1S/C21H17ClN4O/c1-13(15-3-2-4-17(22)11-15)24-21(27)16-5-6-19-18(12-16)20(26-25-19)14-7-9-23-10-8-14/h2-13H,1H3,(H,24,27)(H,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of ABL (unknown origin) by Z-LYTE assay |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50166569
(CHEMBL3798257)Show SMILES CC(NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1)c1c(Cl)cncc1Cl Show InChI InChI=1S/C21H17Cl2N5O/c1-11-7-13(5-6-25-11)20-15-8-14(3-4-18(15)27-28-20)21(29)26-12(2)19-16(22)9-24-10-17(19)23/h3-10,12H,1-2H3,(H,26,29)(H,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of FGFR1 (unknown origin) by Z-LYTE assay |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM50166569
(CHEMBL3798257)Show SMILES CC(NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1)c1c(Cl)cncc1Cl Show InChI InChI=1S/C21H17Cl2N5O/c1-11-7-13(5-6-25-11)20-15-8-14(3-4-18(15)27-28-20)21(29)26-12(2)19-16(22)9-24-10-17(19)23/h3-10,12H,1-2H3,(H,26,29)(H,27,28) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of RET (unknown origin) by Z-LYTE assay |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Ephrin type-A receptor 2
(Homo sapiens (Human)) | BDBM50166569
(CHEMBL3798257)Show SMILES CC(NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1)c1c(Cl)cncc1Cl Show InChI InChI=1S/C21H17Cl2N5O/c1-11-7-13(5-6-25-11)20-15-8-14(3-4-18(15)27-28-20)21(29)26-12(2)19-16(22)9-24-10-17(19)23/h3-10,12H,1-2H3,(H,26,29)(H,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of EPHA2 (unknown origin) by Z-LYTE assay |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50166569
(CHEMBL3798257)Show SMILES CC(NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1)c1c(Cl)cncc1Cl Show InChI InChI=1S/C21H17Cl2N5O/c1-11-7-13(5-6-25-11)20-15-8-14(3-4-18(15)27-28-20)21(29)26-12(2)19-16(22)9-24-10-17(19)23/h3-10,12H,1-2H3,(H,26,29)(H,27,28) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of EGFR (unknown origin) by Z-LYTE assay |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50166569
(CHEMBL3798257)Show SMILES CC(NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1)c1c(Cl)cncc1Cl Show InChI InChI=1S/C21H17Cl2N5O/c1-11-7-13(5-6-25-11)20-15-8-14(3-4-18(15)27-28-20)21(29)26-12(2)19-16(22)9-24-10-17(19)23/h3-10,12H,1-2H3,(H,26,29)(H,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of PDGFRbeta (unknown origin) by Z-LYTE assay |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50166569
(CHEMBL3798257)Show SMILES CC(NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1)c1c(Cl)cncc1Cl Show InChI InChI=1S/C21H17Cl2N5O/c1-11-7-13(5-6-25-11)20-15-8-14(3-4-18(15)27-28-20)21(29)26-12(2)19-16(22)9-24-10-17(19)23/h3-10,12H,1-2H3,(H,26,29)(H,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) by Z-LYTE assay |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50166569
(CHEMBL3798257)Show SMILES CC(NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1)c1c(Cl)cncc1Cl Show InChI InChI=1S/C21H17Cl2N5O/c1-11-7-13(5-6-25-11)20-15-8-14(3-4-18(15)27-28-20)21(29)26-12(2)19-16(22)9-24-10-17(19)23/h3-10,12H,1-2H3,(H,26,29)(H,27,28) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of FLT1 (unknown origin) by Z-LYTE assay |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50166350
(CHEMBL3798631)Show SMILES CC(NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1)c1cccc(Cl)c1 Show InChI InChI=1S/C21H17ClN4O/c1-13(15-3-2-4-17(22)11-15)24-21(27)16-5-6-19-18(12-16)20(26-25-19)14-7-9-23-10-8-14/h2-13H,1H3,(H,24,27)(H,25,26) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of c-Src (unknown origin) by Z-LYTE assay |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50166350
(CHEMBL3798631)Show SMILES CC(NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1)c1cccc(Cl)c1 Show InChI InChI=1S/C21H17ClN4O/c1-13(15-3-2-4-17(22)11-15)24-21(27)16-5-6-19-18(12-16)20(26-25-19)14-7-9-23-10-8-14/h2-13H,1H3,(H,24,27)(H,25,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) by Z-LYTE assay |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Ephrin type-A receptor 2
(Homo sapiens (Human)) | BDBM50166350
(CHEMBL3798631)Show SMILES CC(NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1)c1cccc(Cl)c1 Show InChI InChI=1S/C21H17ClN4O/c1-13(15-3-2-4-17(22)11-15)24-21(27)16-5-6-19-18(12-16)20(26-25-19)14-7-9-23-10-8-14/h2-13H,1H3,(H,24,27)(H,25,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of EPHA2 (unknown origin) by Z-LYTE assay |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50166421
(CHEMBL3800463)Show SMILES CC(C)CC(NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1)c1cccc(Cl)c1 Show InChI InChI=1S/C24H23ClN4O/c1-15(2)12-22(17-4-3-5-19(25)13-17)27-24(30)18-6-7-21-20(14-18)23(29-28-21)16-8-10-26-11-9-16/h3-11,13-15,22H,12H2,1-2H3,(H,27,30)(H,28,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Valley Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged ERK2 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft... |
Bioorg Med Chem Lett 26: 2600-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.029
BindingDB Entry DOI: 10.7270/Q2H99731 |
More data for this
Ligand-Target Pair | |
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