Compile Data Set for Download or QSAR

Found 70 hits with Last Name = 'tolf' and Initial = 'br'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50232153 ((1-(4-fluorophenethyl)piperidin-4-yl)(2,3-dimethox...) Show SMILES COc1cccc(C(O)C2CCN(CCc3ccc(F)cc3)CC2)c1OC Show InChI InChI=1S/C22H28FNO3/c1-26-20-5-3-4-19(22(20)27-2)21(25)17-11-14-24(15-12-17)13-10-16-6-8-18(23)9-7-16/h3-9,17,21,25H,10-15H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.0300	-55.8	n/a	n/a	n/a	n/a	n/a	n/a	4
ACADIA Pharmaceuticals Inc.					Assay Description For the membrane binding, NIH-3T3 cells were grown to 70% confluence in 15-cm2 dishes and transfected with 10 ug of receptor plasmid DNA using Polyfe...				J Pharmacol Exp Ther 317: 910-8 (2006) Article DOI: 10.1124/jpet.105.097006 BindingDB Entry DOI: 10.7270/Q269728N
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM139371 (eplivanserin) Show SMILES [#6]-[#7](-[#6])-[#6]-[#6]-[#8]-[#7]\[#6](=[#6]\[#6]=[#6]-1\[#6]=[#6]-[#6](=O)-[#6]=[#6]-1)-c1ccccc1F |c:11,15| Show InChI InChI=1S/C19H21FN2O2/c1-22(2)13-14-24-21-19(17-5-3-4-6-18(17)20)12-9-15-7-10-16(23)11-8-15/h3-12,21H,13-14H2,1-2H3/b19-12+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	0.0460	-54.8	n/a	n/a	n/a	n/a	n/a	n/a	4
ACADIA Pharmaceuticals Inc.					Assay Description For the membrane binding, NIH-3T3 cells were grown to 70% confluence in 15-cm2 dishes and transfected with 10 ug of receptor plasmid DNA using Polyfe...				J Pharmacol Exp Ther 317: 910-8 (2006) Article DOI: 10.1124/jpet.105.097006 BindingDB Entry DOI: 10.7270/Q269728N
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50001775 ((ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methyle...) Show SMILES [#6]-c1nc2sccn2c(=O)c1-[#6]-[#6]-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6](\c1ccc(F)cc1)-c1ccc(F)cc1 Show InChI InChI=1S/C27H25F2N3OS/c1-18-24(26(33)32-16-17-34-27(32)30-18)12-15-31-13-10-21(11-14-31)25(19-2-6-22(28)7-3-19)20-4-8-23(29)9-5-20/h2-9,16-17H,10-15H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	0.0830	-53.5	n/a	n/a	n/a	n/a	n/a	n/a	4
ACADIA Pharmaceuticals Inc.					Assay Description For the membrane binding, NIH-3T3 cells were grown to 70% confluence in 15-cm2 dishes and transfected with 10 ug of receptor plasmid DNA using Polyfe...				J Pharmacol Exp Ther 317: 910-8 (2006) Article DOI: 10.1124/jpet.105.097006 BindingDB Entry DOI: 10.7270/Q269728N
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50090771 ((R)-1-[3-(Isopropyl-propyl-amino)-chroman-5-yl]-et...) Show SMILES CCCN(C(C)C)C1COc2cccc(C(C)=O)c2C1 Show InChI InChI=1S/C17H25NO2/c1-5-9-18(12(2)3)14-10-16-15(13(4)19)7-6-8-17(16)20-11-14/h6-8,12,14H,5,9-11H2,1-4H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	0.300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Södertälje Curated by ChEMBL					Assay Description In vitro binding affinity at 5-HT1A receptors assayed by displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor in rat hippocampal membr...				J Med Chem 43: 2837-50 (2000) BindingDB Entry DOI: 10.7270/Q2610ZJK
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50090762 ((R)-3-(Isopropyl-propyl-amino)-chroman-5-carboxyli...) Show SMILES CCCN(C(C)C)C1COc2cccc(C(=O)OC)c2C1 Show InChI InChI=1S/C17H25NO3/c1-5-9-18(12(2)3)13-10-15-14(17(19)20-4)7-6-8-16(15)21-11-13/h6-8,12-13H,5,9-11H2,1-4H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	0.320	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Södertälje Curated by ChEMBL					Assay Description In vitro binding affinity at 5-HT1A receptors assayed by displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor in rat hippocampal membr...				J Med Chem 43: 2837-50 (2000) BindingDB Entry DOI: 10.7270/Q2610ZJK
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50090763 ((R)-3-{[4-(7,9-Dioxo-8-aza-spiro[4.5]dec-8-yl)-but...) Show SMILES CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(C(=O)NC)c2C1 Show InChI InChI=1S/C27H39N3O4/c1-3-13-29(20-16-22-21(26(33)28-2)9-8-10-23(22)34-19-20)14-6-7-15-30-24(31)17-27(18-25(30)32)11-4-5-12-27/h8-10,20H,3-7,11-19H2,1-2H3,(H,28,33)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.340	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Södertälje Curated by ChEMBL					Assay Description In vitro binding affinity at 5-HT1A receptors assayed by displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor in rat hippocampal membr...				J Med Chem 43: 2837-50 (2000) BindingDB Entry DOI: 10.7270/Q2610ZJK
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50090756 ((R)-3-(Cyclopentyl-propyl-amino)-chroman-5-carboxy...) Show SMILES CCCN(C1CCCC1)C1COc2cccc(C(=O)OC)c2C1 Show InChI InChI=1S/C19H27NO3/c1-3-11-20(14-7-4-5-8-14)15-12-17-16(19(21)22-2)9-6-10-18(17)23-13-15/h6,9-10,14-15H,3-5,7-8,11-13H2,1-2H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.410	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Södertälje Curated by ChEMBL					Assay Description In vitro binding affinity at 5-HT1A receptors assayed by displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor in rat hippocampal membr...				J Med Chem 43: 2837-50 (2000) BindingDB Entry DOI: 10.7270/Q2610ZJK
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50001775 ((ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methyle...) Show SMILES [#6]-c1nc2sccn2c(=O)c1-[#6]-[#6]-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6](\c1ccc(F)cc1)-c1ccc(F)cc1 Show InChI InChI=1S/C27H25F2N3OS/c1-18-24(26(33)32-16-17-34-27(32)30-18)12-15-31-13-10-21(11-14-31)25(19-2-6-22(28)7-3-19)20-4-8-23(29)9-5-20/h2-9,16-17H,10-15H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	0.440	-49.6	n/a	n/a	n/a	n/a	n/a	n/a	4
ACADIA Pharmaceuticals Inc.					Assay Description For the membrane binding, NIH-3T3 cells were grown to 70% confluence in 15-cm2 dishes and transfected with 10 ug of receptor plasmid DNA using Polyfe...				J Pharmacol Exp Ther 317: 910-8 (2006) Article DOI: 10.1124/jpet.105.097006 BindingDB Entry DOI: 10.7270/Q269728N
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50090764 ((R)-3-(Isopropyl-propyl-amino)-chroman-5-carboxyli...) Show SMILES CCCN(C(C)C)C1COc2cccc(C(N)=O)c2C1 Show InChI InChI=1S/C16H24N2O2/c1-4-8-18(11(2)3)12-9-14-13(16(17)19)6-5-7-15(14)20-10-12/h5-7,11-12H,4,8-10H2,1-3H3,(H2,17,19)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	0.480	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Södertälje Curated by ChEMBL					Assay Description In vitro binding affinity at 5-HT1A receptors assayed by displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor in rat hippocampal membr...				J Med Chem 43: 2837-50 (2000) BindingDB Entry DOI: 10.7270/Q2610ZJK
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM139370 (ACP-103 | Nuplazid | Pimavanserin | Pimavanserin h...) Show SMILES CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cc2)C2CCN(C)CC2)cc1 Show InChI InChI=1S/C25H34FN3O2/c1-19(2)18-31-24-10-6-20(7-11-24)16-27-25(30)29(23-12-14-28(3)15-13-23)17-21-4-8-22(26)9-5-21/h4-11,19,23H,12-18H2,1-3H3,(H,27,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid UniChem	Article PubMed	0.5	-49.3	n/a	n/a	n/a	n/a	n/a	n/a	4
ACADIA Pharmaceuticals Inc.					Assay Description For the membrane binding, NIH-3T3 cells were grown to 70% confluence in 15-cm2 dishes and transfected with 10 ug of receptor plasmid DNA using Polyfe...				J Pharmacol Exp Ther 317: 910-8 (2006) Article DOI: 10.1124/jpet.105.097006 BindingDB Entry DOI: 10.7270/Q269728N
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM22869 (6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...) Show SMILES CN1CCN(CC1)C1=c2ccccc2=Nc2ccc(Cl)cc2N1 |c:8,15| Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,21H,8-11H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	0.550	-49.1	n/a	n/a	n/a	n/a	n/a	n/a	4
ACADIA Pharmaceuticals Inc.					Assay Description For the membrane binding, NIH-3T3 cells were grown to 70% confluence in 15-cm2 dishes and transfected with 10 ug of receptor plasmid DNA using Polyfe...				J Pharmacol Exp Ther 317: 910-8 (2006) Article DOI: 10.1124/jpet.105.097006 BindingDB Entry DOI: 10.7270/Q269728N
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM21398 (4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...) Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1 Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	0.700	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
ACADIA Pharmaceuticals, Inc., Curated by PDSP Ki Database									J Pharmacol Exp Ther 310: 943-51 (2004) Article DOI: 10.1124/jpet.104.066688 BindingDB Entry DOI: 10.7270/Q28S4NH4
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50073274 (3-Methyl-7-[3-(4-phenyl-piperazin-1-yl)-propoxy]-c...) Show SMILES Cc1cc2ccc(OCCCN3CCN(CC3)c3ccccc3)cc2oc1=O Show InChI InChI=1S/C23H26N2O3/c1-18-16-19-8-9-21(17-22(19)28-23(18)26)27-15-5-10-24-11-13-25(14-12-24)20-6-3-2-4-7-20/h2-4,6-9,16-17H,5,10-15H2,1H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.790	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Vigo Curated by ChEMBL					Assay Description Compound was measured for the inhibition of [3H]-8-OH-DPAT binding to rat hippocampus membrane (5-HT1A receptor)				Bioorg Med Chem Lett 8: 3567-70 (1999) BindingDB Entry DOI: 10.7270/Q2CV4GWM
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM22869 (6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...) Show SMILES CN1CCN(CC1)C1=c2ccccc2=Nc2ccc(Cl)cc2N1 |c:8,15| Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,21H,8-11H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
ACADIA Pharmaceuticals, Inc., Curated by PDSP Ki Database									J Pharmacol Exp Ther 310: 943-51 (2004) Article DOI: 10.1124/jpet.104.066688 BindingDB Entry DOI: 10.7270/Q28S4NH4
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM139371 (eplivanserin) Show SMILES [#6]-[#7](-[#6])-[#6]-[#6]-[#8]-[#7]\[#6](=[#6]\[#6]=[#6]-1\[#6]=[#6]-[#6](=O)-[#6]=[#6]-1)-c1ccccc1F |c:11,15| Show InChI InChI=1S/C19H21FN2O2/c1-22(2)13-14-24-21-19(17-5-3-4-6-18(17)20)12-9-15-7-10-16(23)11-8-15/h3-12,21H,13-14H2,1-2H3/b19-12+	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	1.30	-47.1	n/a	n/a	n/a	n/a	n/a	n/a	4
ACADIA Pharmaceuticals Inc.					Assay Description For the membrane binding, NIH-3T3 cells were grown to 70% confluence in 15-cm2 dishes and transfected with 10 ug of receptor plasmid DNA using Polyfe...				J Pharmacol Exp Ther 317: 910-8 (2006) Article DOI: 10.1124/jpet.105.097006 BindingDB Entry DOI: 10.7270/Q269728N
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM22869 (6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...) Show SMILES CN1CCN(CC1)C1=c2ccccc2=Nc2ccc(Cl)cc2N1 |c:8,15| Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,21H,8-11H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	1.30	-47.1	n/a	n/a	n/a	n/a	n/a	n/a	4
ACADIA Pharmaceuticals Inc.					Assay Description For the membrane binding, NIH-3T3 cells were grown to 70% confluence in 15-cm2 dishes and transfected with 10 ug of receptor plasmid DNA using Polyfe...				J Pharmacol Exp Ther 317: 910-8 (2006) Article DOI: 10.1124/jpet.105.097006 BindingDB Entry DOI: 10.7270/Q269728N
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM139370 (ACP-103 | Nuplazid | Pimavanserin | Pimavanserin h...) Show SMILES CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cc2)C2CCN(C)CC2)cc1 Show InChI InChI=1S/C25H34FN3O2/c1-19(2)18-31-24-10-6-20(7-11-24)16-27-25(30)29(23-12-14-28(3)15-13-23)17-21-4-8-22(26)9-5-21/h4-11,19,23H,12-18H2,1-3H3,(H,27,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid UniChem	Article PubMed	1.60	-46.7	n/a	n/a	n/a	n/a	n/a	n/a	4
ACADIA Pharmaceuticals Inc.					Assay Description For the membrane binding, NIH-3T3 cells were grown to 70% confluence in 15-cm2 dishes and transfected with 10 ug of receptor plasmid DNA using Polyfe...				J Pharmacol Exp Ther 317: 910-8 (2006) Article DOI: 10.1124/jpet.105.097006 BindingDB Entry DOI: 10.7270/Q269728N
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM22869 (6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...) Show SMILES CN1CCN(CC1)C1=c2ccccc2=Nc2ccc(Cl)cc2N1 |c:8,15| Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,21H,8-11H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	1.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
ACADIA Pharmaceuticals, Inc., Curated by PDSP Ki Database									J Pharmacol Exp Ther 310: 943-51 (2004) Article DOI: 10.1124/jpet.104.066688 BindingDB Entry DOI: 10.7270/Q28S4NH4
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50090772 ((R)-3-(Isobutyl-propyl-amino)-chroman-5-carboxylic...) Show SMILES CCCN(CC(C)C)C1COc2cccc(C(=O)NC)c2C1 Show InChI InChI=1S/C18H28N2O2/c1-5-9-20(11-13(2)3)14-10-16-15(18(21)19-4)7-6-8-17(16)22-12-14/h6-8,13-14H,5,9-12H2,1-4H3,(H,19,21)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	2.37	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Södertälje Curated by ChEMBL					Assay Description In vitro binding affinity at 5-HT1A receptors assayed by displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor in rat hippocampal membr...				J Med Chem 43: 2837-50 (2000) BindingDB Entry DOI: 10.7270/Q2610ZJK
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM86496 (AC-90179 | N-(4-Methylbenzyl)-N-(1-methyl-4-piperi...) Show SMILES COc1ccc(CC(=O)N(Cc2ccc(C)cc2)C2CCN(C)CC2)cc1 Show InChI InChI=1S/C23H30N2O2/c1-18-4-6-20(7-5-18)17-25(21-12-14-24(2)15-13-21)23(26)16-19-8-10-22(27-3)11-9-19/h4-11,21H,12-17H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	2.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
ACADIA Pharmaceuticals, Inc., Curated by PDSP Ki Database									J Pharmacol Exp Ther 310: 943-51 (2004) Article DOI: 10.1124/jpet.104.066688 BindingDB Entry DOI: 10.7270/Q28S4NH4
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50090770 ((R)-Isopropyl-(5-methoxy-chroman-3-yl)-propyl-amin...) Show SMILES CCCN(C(C)C)C1COc2cccc(OC)c2C1 Show InChI InChI=1S/C16H25NO2/c1-5-9-17(12(2)3)13-10-14-15(18-4)7-6-8-16(14)19-11-13/h6-8,12-13H,5,9-11H2,1-4H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	3.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Södertälje Curated by ChEMBL					Assay Description In vitro binding affinity at 5-HT1A receptor by measuring its ability to displace [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor in rat hippocam...				J Med Chem 43: 2837-50 (2000) BindingDB Entry DOI: 10.7270/Q2610ZJK
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50232153 ((1-(4-fluorophenethyl)piperidin-4-yl)(2,3-dimethox...) Show SMILES COc1cccc(C(O)C2CCN(CCc3ccc(F)cc3)CC2)c1OC Show InChI InChI=1S/C22H28FNO3/c1-26-20-5-3-4-19(22(20)27-2)21(25)17-11-14-24(15-12-17)13-10-16-6-8-18(23)9-7-16/h3-9,17,21,25H,10-15H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	3.80	-44.7	n/a	n/a	n/a	n/a	n/a	n/a	4
ACADIA Pharmaceuticals Inc.					Assay Description For the membrane binding, NIH-3T3 cells were grown to 70% confluence in 15-cm2 dishes and transfected with 10 ug of receptor plasmid DNA using Polyfe...				J Pharmacol Exp Ther 317: 910-8 (2006) Article DOI: 10.1124/jpet.105.097006 BindingDB Entry DOI: 10.7270/Q269728N
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50073273 (3,4-Dimethyl-7-[3-(4-phenyl-piperazin-1-yl)-propox...) Show SMILES Cc1c(C)c(=O)oc2cc(OCCCN3CCN(CC3)c3ccccc3)ccc12 Show InChI InChI=1S/C24H28N2O3/c1-18-19(2)24(27)29-23-17-21(9-10-22(18)23)28-16-6-11-25-12-14-26(15-13-25)20-7-4-3-5-8-20/h3-5,7-10,17H,6,11-16H2,1-2H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	5.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Vigo Curated by ChEMBL					Assay Description Compound was measured for the inhibition of [3H]-8-OH-DPAT binding to rat hippocampus membrane (5-HT1A receptor)				Bioorg Med Chem Lett 8: 3567-70 (1999) BindingDB Entry DOI: 10.7270/Q2CV4GWM
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50073272 (4-Methyl-7-[3-(4-phenyl-piperazin-1-yl)-propoxy]-c...) Show SMILES Cc1cc(=O)oc2cc(OCCCN3CCN(CC3)c3ccccc3)ccc12 Show InChI InChI=1S/C23H26N2O3/c1-18-16-23(26)28-22-17-20(8-9-21(18)22)27-15-5-10-24-11-13-25(14-12-24)19-6-3-2-4-7-19/h2-4,6-9,16-17H,5,10-15H2,1H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	5.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Vigo Curated by ChEMBL					Assay Description Compound was measured for the inhibition of [3H]-8-OH-DPAT binding to rat hippocampus membrane (5-HT1A receptor)				Bioorg Med Chem Lett 8: 3567-70 (1999) BindingDB Entry DOI: 10.7270/Q2CV4GWM
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50073271 (7-[3-(4-Phenyl-piperazin-1-yl)-propoxy]-chromen-2-...) Show SMILES O=c1ccc2ccc(OCCCN3CCN(CC3)c3ccccc3)cc2o1 Show InChI InChI=1S/C22H24N2O3/c25-22-10-8-18-7-9-20(17-21(18)27-22)26-16-4-11-23-12-14-24(15-13-23)19-5-2-1-3-6-19/h1-3,5-10,17H,4,11-16H2	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	5.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Vigo Curated by ChEMBL					Assay Description Compound was measured for the inhibition of [3H]-8-OH-DPAT binding to rat hippocampus membrane (5-HT1A receptor)				Bioorg Med Chem Lett 8: 3567-70 (1999) BindingDB Entry DOI: 10.7270/Q2CV4GWM
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50073273 (3,4-Dimethyl-7-[3-(4-phenyl-piperazin-1-yl)-propox...) Show SMILES Cc1c(C)c(=O)oc2cc(OCCCN3CCN(CC3)c3ccccc3)ccc12 Show InChI InChI=1S/C24H28N2O3/c1-18-19(2)24(27)29-23-17-21(9-10-22(18)23)28-16-6-11-25-12-14-26(15-13-25)20-7-4-3-5-8-20/h3-5,7-10,17H,6,11-16H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	5.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Vigo Curated by ChEMBL					Assay Description Compound was measured for the binding affinity in homogenated mouse fibroblast (LTK) cells transfected with human Dopamine receptor D2A using [3H]-ra...				Bioorg Med Chem Lett 8: 3567-70 (1999) BindingDB Entry DOI: 10.7270/Q2CV4GWM
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50073274 (3-Methyl-7-[3-(4-phenyl-piperazin-1-yl)-propoxy]-c...) Show SMILES Cc1cc2ccc(OCCCN3CCN(CC3)c3ccccc3)cc2oc1=O Show InChI InChI=1S/C23H26N2O3/c1-18-16-19-8-9-21(17-22(19)28-23(18)26)27-15-5-10-24-11-13-25(14-12-24)20-6-3-2-4-7-20/h2-4,6-9,16-17H,5,10-15H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	11	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Vigo Curated by ChEMBL					Assay Description Compound was measured for the binding affinity in homogenated mouse fibroblast (LTK) cells transfected with human Dopamine receptor D2A using [3H]-ra...				Bioorg Med Chem Lett 8: 3567-70 (1999) BindingDB Entry DOI: 10.7270/Q2CV4GWM
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50090771 ((R)-1-[3-(Isopropyl-propyl-amino)-chroman-5-yl]-et...) Show SMILES CCCN(C(C)C)C1COc2cccc(C(C)=O)c2C1 Show InChI InChI=1S/C17H25NO2/c1-5-9-18(12(2)3)14-10-16-15(13(4)19)7-6-8-17(16)20-11-14/h6-8,12,14H,5,9-11H2,1-4H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	11.9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Södertälje Curated by ChEMBL					Assay Description In vitro binding affinity at 5-HT1A receptors assayed by displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor in rat hippocampal membr...				J Med Chem 43: 2837-50 (2000) BindingDB Entry DOI: 10.7270/Q2610ZJK
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50073272 (4-Methyl-7-[3-(4-phenyl-piperazin-1-yl)-propoxy]-c...) Show SMILES Cc1cc(=O)oc2cc(OCCCN3CCN(CC3)c3ccccc3)ccc12 Show InChI InChI=1S/C23H26N2O3/c1-18-16-23(26)28-22-17-20(8-9-21(18)22)27-15-5-10-24-11-13-25(14-12-24)19-6-3-2-4-7-19/h2-4,6-9,16-17H,5,10-15H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Vigo Curated by ChEMBL					Assay Description Compound was measured for the binding affinity in homogenated mouse fibroblast (LTK) cells transfected with human Dopamine receptor D2A using [3H]-ra...				Bioorg Med Chem Lett 8: 3567-70 (1999) BindingDB Entry DOI: 10.7270/Q2CV4GWM
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50090759 ((R)-3-Dipropylamino-chroman-5-carboxylic acid isop...) Show SMILES CCCN(CCC)C1COc2cccc(C(=O)NC(C)C)c2C1 Show InChI InChI=1S/C19H30N2O2/c1-5-10-21(11-6-2)15-12-17-16(19(22)20-14(3)4)8-7-9-18(17)23-13-15/h7-9,14-15H,5-6,10-13H2,1-4H3,(H,20,22)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Södertälje Curated by ChEMBL					Assay Description In vitro binding affinity at 5-HT1A receptors assayed by displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor in rat hippocampal membr...				J Med Chem 43: 2837-50 (2000) BindingDB Entry DOI: 10.7270/Q2610ZJK
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50073271 (7-[3-(4-Phenyl-piperazin-1-yl)-propoxy]-chromen-2-...) Show SMILES O=c1ccc2ccc(OCCCN3CCN(CC3)c3ccccc3)cc2o1 Show InChI InChI=1S/C22H24N2O3/c25-22-10-8-18-7-9-20(17-21(18)27-22)26-16-4-11-23-12-14-24(15-13-23)19-5-2-1-3-6-19/h1-3,5-10,17H,4,11-16H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Vigo Curated by ChEMBL					Assay Description Compound was measured for the binding affinity in homogenated mouse fibroblast (LTK) cells transfected with human Dopamine receptor D2A using [3H]-ra...				Bioorg Med Chem Lett 8: 3567-70 (1999) BindingDB Entry DOI: 10.7270/Q2CV4GWM
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50090761 ((R)-3-(Cyclopentyl-propyl-amino)-chroman-5-carboxy...) Show SMILES CCCN(C1CCCC1)C1COc2cccc(C(=O)NC)c2C1 Show InChI InChI=1S/C19H28N2O2/c1-3-11-21(14-7-4-5-8-14)15-12-17-16(19(22)20-2)9-6-10-18(17)23-13-15/h6,9-10,14-15H,3-5,7-8,11-13H2,1-2H3,(H,20,22)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	18.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Södertälje Curated by ChEMBL					Assay Description In vitro binding affinity at 5-HT1A receptors assayed by displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor in rat hippocampal membr...				J Med Chem 43: 2837-50 (2000) BindingDB Entry DOI: 10.7270/Q2610ZJK
					More data for this Ligand-Target Pair
D(3) dopamine receptor (Homo sapiens (Human))	BDBM50073274 (3-Methyl-7-[3-(4-phenyl-piperazin-1-yl)-propoxy]-c...) Show SMILES Cc1cc2ccc(OCCCN3CCN(CC3)c3ccccc3)cc2oc1=O Show InChI InChI=1S/C23H26N2O3/c1-18-16-19-8-9-21(17-22(19)28-23(18)26)27-15-5-10-24-11-13-25(14-12-24)20-6-3-2-4-7-20/h2-4,6-9,16-17H,5,10-15H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	19	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Vigo Curated by ChEMBL					Assay Description Compound was measured for the binding affinity in chinese hamster ovary (CHO) cells transfected with human Dopamine receptor D3 using [3H]-raclopride...				Bioorg Med Chem Lett 8: 3567-70 (1999) BindingDB Entry DOI: 10.7270/Q2CV4GWM
					More data for this Ligand-Target Pair
D(3) dopamine receptor (Homo sapiens (Human))	BDBM50073273 (3,4-Dimethyl-7-[3-(4-phenyl-piperazin-1-yl)-propox...) Show SMILES Cc1c(C)c(=O)oc2cc(OCCCN3CCN(CC3)c3ccccc3)ccc12 Show InChI InChI=1S/C24H28N2O3/c1-18-19(2)24(27)29-23-17-21(9-10-22(18)23)28-16-6-11-25-12-14-26(15-13-25)20-7-4-3-5-8-20/h3-5,7-10,17H,6,11-16H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	45	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Vigo Curated by ChEMBL					Assay Description Compound was measured for the binding affinity in chinese hamster ovary (CHO) cells transfected with human Dopamine receptor D3 using [3H]-raclopride...				Bioorg Med Chem Lett 8: 3567-70 (1999) BindingDB Entry DOI: 10.7270/Q2CV4GWM
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM22869 (6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...) Show SMILES CN1CCN(CC1)C1=c2ccccc2=Nc2ccc(Cl)cc2N1 |c:8,15| Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,21H,8-11H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	49.9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
ACADIA Pharmaceuticals, Inc., Curated by PDSP Ki Database									J Pharmacol Exp Ther 310: 943-51 (2004) Article DOI: 10.1124/jpet.104.066688 BindingDB Entry DOI: 10.7270/Q28S4NH4
					More data for this Ligand-Target Pair
D(3) dopamine receptor (Homo sapiens (Human))	BDBM50073271 (7-[3-(4-Phenyl-piperazin-1-yl)-propoxy]-chromen-2-...) Show SMILES O=c1ccc2ccc(OCCCN3CCN(CC3)c3ccccc3)cc2o1 Show InChI InChI=1S/C22H24N2O3/c25-22-10-8-18-7-9-20(17-21(18)27-22)26-16-4-11-23-12-14-24(15-13-23)19-5-2-1-3-6-19/h1-3,5-10,17H,4,11-16H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	50	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Vigo Curated by ChEMBL					Assay Description Compound was measured for the binding affinity in chinese hamster ovary (CHO) cells transfected with human Dopamine receptor D3 using [3H]-raclopride...				Bioorg Med Chem Lett 8: 3567-70 (1999) BindingDB Entry DOI: 10.7270/Q2CV4GWM
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50090759 ((R)-3-Dipropylamino-chroman-5-carboxylic acid isop...) Show SMILES CCCN(CCC)C1COc2cccc(C(=O)NC(C)C)c2C1 Show InChI InChI=1S/C19H30N2O2/c1-5-10-21(11-6-2)15-12-17-16(19(22)20-14(3)4)8-7-9-18(17)23-13-15/h7-9,14-15H,5-6,10-13H2,1-4H3,(H,20,22)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	64	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Södertälje Curated by ChEMBL					Assay Description In vitro binding affinity at 5-HT1A receptor by measuring its ability to displace [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor in rat hippocam...				J Med Chem 43: 2837-50 (2000) BindingDB Entry DOI: 10.7270/Q2610ZJK
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM21398 (4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...) Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1 Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	70.2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
ACADIA Pharmaceuticals, Inc., Curated by PDSP Ki Database									J Pharmacol Exp Ther 310: 943-51 (2004) Article DOI: 10.1124/jpet.104.066688 BindingDB Entry DOI: 10.7270/Q28S4NH4
					More data for this Ligand-Target Pair
D(3) dopamine receptor (Homo sapiens (Human))	BDBM50073272 (4-Methyl-7-[3-(4-phenyl-piperazin-1-yl)-propoxy]-c...) Show SMILES Cc1cc(=O)oc2cc(OCCCN3CCN(CC3)c3ccccc3)ccc12 Show InChI InChI=1S/C23H26N2O3/c1-18-16-23(26)28-22-17-20(8-9-21(18)22)27-15-5-10-24-11-13-25(14-12-24)19-6-3-2-4-7-19/h2-4,6-9,16-17H,5,10-15H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	74	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Vigo Curated by ChEMBL					Assay Description Compound was measured for the binding affinity in chinese hamster ovary (CHO) cells transfected with human Dopamine receptor D3 using [3H]-raclopride...				Bioorg Med Chem Lett 8: 3567-70 (1999) BindingDB Entry DOI: 10.7270/Q2CV4GWM
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50090754 ((R)-3-Propylamino-chroman-5-carboxylic acid amide ...) Show SMILES CCCNC1COc2cccc(C(N)=O)c2C1 Show InChI InChI=1S/C13H18N2O2/c1-2-6-15-9-7-11-10(13(14)16)4-3-5-12(11)17-8-9/h3-5,9,15H,2,6-8H2,1H3,(H2,14,16)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	98.4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Södertälje Curated by ChEMBL					Assay Description In vitro binding affinity at 5-HT1A receptors assayed by displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor in rat hippocampal membr...				J Med Chem 43: 2837-50 (2000) BindingDB Entry DOI: 10.7270/Q2610ZJK
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50090770 ((R)-Isopropyl-(5-methoxy-chroman-3-yl)-propyl-amin...) Show SMILES CCCN(C(C)C)C1COc2cccc(OC)c2C1 Show InChI InChI=1S/C16H25NO2/c1-5-9-17(12(2)3)13-10-14-15(18-4)7-6-8-16(14)19-11-13/h6-8,12-13H,5,9-11H2,1-4H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	134	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Södertälje Curated by ChEMBL					Assay Description In vitro binding affinity at 5-HT1A receptor by measuring its ability to displace [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor in rat hippocam...				J Med Chem 43: 2837-50 (2000) BindingDB Entry DOI: 10.7270/Q2610ZJK
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50090757 ((R)-3-Isopropylamino-chroman-5-carboxylic acid ami...) Show SMILES CC(C)NC1COc2cccc(C(N)=O)c2C1 Show InChI InChI=1S/C13H18N2O2/c1-8(2)15-9-6-11-10(13(14)16)4-3-5-12(11)17-7-9/h3-5,8-9,15H,6-7H2,1-2H3,(H2,14,16)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	397	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Södertälje Curated by ChEMBL					Assay Description In vitro binding affinity at 5-HT1A receptors assayed by displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor in rat hippocampal membr...				J Med Chem 43: 2837-50 (2000) BindingDB Entry DOI: 10.7270/Q2610ZJK
					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM50090759 ((R)-3-Dipropylamino-chroman-5-carboxylic acid isop...) Show SMILES CCCN(CCC)C1COc2cccc(C(=O)NC(C)C)c2C1 Show InChI InChI=1S/C19H30N2O2/c1-5-10-21(11-6-2)15-12-17-16(19(22)20-14(3)4)8-7-9-18(17)23-13-15/h7-9,14-15H,5-6,10-13H2,1-4H3,(H,20,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Södertälje Curated by ChEMBL					Assay Description In vitro binding affinity at D1 receptor by measuring its ability to displace [3H]-SCH-23,390 from Dopamine receptor D1 in rat striatum				J Med Chem 43: 2837-50 (2000) BindingDB Entry DOI: 10.7270/Q2610ZJK
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50090758 ((R)-3-(Cyclopentyl-propyl-amino)-chroman-5-carboxy...) Show SMILES CCCN(C1CCCC1)C1COc2cccc(C(N)=O)c2C1 Show InChI InChI=1S/C18H26N2O2/c1-2-10-20(13-6-3-4-7-13)14-11-16-15(18(19)21)8-5-9-17(16)22-12-14/h5,8-9,13-14H,2-4,6-7,10-12H2,1H3,(H2,19,21)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Södertälje Curated by ChEMBL					Assay Description In vitro binding affinity at human cloned Dopamine receptor D2A measured by ability to displace [3H]-raclopride from D2A receptor expressed in mouse ...				J Med Chem 43: 2837-50 (2000) BindingDB Entry DOI: 10.7270/Q2610ZJK
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50090754 ((R)-3-Propylamino-chroman-5-carboxylic acid amide ...) Show SMILES CCCNC1COc2cccc(C(N)=O)c2C1 Show InChI InChI=1S/C13H18N2O2/c1-2-6-15-9-7-11-10(13(14)16)4-3-5-12(11)17-8-9/h3-5,9,15H,2,6-8H2,1H3,(H2,14,16)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Södertälje Curated by ChEMBL					Assay Description In vitro binding affinity at human cloned Dopamine receptor D2A measured by ability to displace [3H]-raclopride from D2A receptor expressed in mouse ...				J Med Chem 43: 2837-50 (2000) BindingDB Entry DOI: 10.7270/Q2610ZJK
					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM50090757 ((R)-3-Isopropylamino-chroman-5-carboxylic acid ami...) Show SMILES CC(C)NC1COc2cccc(C(N)=O)c2C1 Show InChI InChI=1S/C13H18N2O2/c1-8(2)15-9-6-11-10(13(14)16)4-3-5-12(11)17-7-9/h3-5,8-9,15H,6-7H2,1-2H3,(H2,14,16)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Södertälje Curated by ChEMBL					Assay Description In vitro binding affinity at D1 receptor by measuring its ability to displace [3H]-SCH-23,390 from Dopamine receptor D1 in rat striatum				J Med Chem 43: 2837-50 (2000) BindingDB Entry DOI: 10.7270/Q2610ZJK
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat))	BDBM50090764 ((R)-3-(Isopropyl-propyl-amino)-chroman-5-carboxyli...) Show SMILES CCCN(C(C)C)C1COc2cccc(C(N)=O)c2C1 Show InChI InChI=1S/C16H24N2O2/c1-4-8-18(11(2)3)12-9-14-13(16(17)19)6-5-7-15(14)20-10-12/h5-7,11-12H,4,8-10H2,1-3H3,(H2,17,19)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Södertälje Curated by ChEMBL					Assay Description In vitro binding affinity at 5-hydroxytryptamine 2A receptor by displacement of [3H]-ketanserin from rat cortex				J Med Chem 43: 2837-50 (2000) BindingDB Entry DOI: 10.7270/Q2610ZJK
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat))	BDBM50090754 ((R)-3-Propylamino-chroman-5-carboxylic acid amide ...) Show SMILES CCCNC1COc2cccc(C(N)=O)c2C1 Show InChI InChI=1S/C13H18N2O2/c1-2-6-15-9-7-11-10(13(14)16)4-3-5-12(11)17-8-9/h3-5,9,15H,2,6-8H2,1H3,(H2,14,16)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Södertälje Curated by ChEMBL					Assay Description In vitro binding affinity at 5-hydroxytryptamine 2A receptor by displacement of [3H]-ketanserin from rat cortex				J Med Chem 43: 2837-50 (2000) BindingDB Entry DOI: 10.7270/Q2610ZJK
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat))	BDBM50090758 ((R)-3-(Cyclopentyl-propyl-amino)-chroman-5-carboxy...) Show SMILES CCCN(C1CCCC1)C1COc2cccc(C(N)=O)c2C1 Show InChI InChI=1S/C18H26N2O2/c1-2-10-20(13-6-3-4-7-13)14-11-16-15(18(19)21)8-5-9-17(16)22-12-14/h5,8-9,13-14H,2-4,6-7,10-12H2,1H3,(H2,19,21)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Södertälje Curated by ChEMBL					Assay Description In vitro binding affinity at 5-hydroxytryptamine 2A receptor by displacement of [3H]-ketanserin from rat cortex				J Med Chem 43: 2837-50 (2000) BindingDB Entry DOI: 10.7270/Q2610ZJK
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50090759 ((R)-3-Dipropylamino-chroman-5-carboxylic acid isop...) Show SMILES CCCN(CCC)C1COc2cccc(C(=O)NC(C)C)c2C1 Show InChI InChI=1S/C19H30N2O2/c1-5-10-21(11-6-2)15-12-17-16(19(22)20-14(3)4)8-7-9-18(17)23-13-15/h7-9,14-15H,5-6,10-13H2,1-4H3,(H,20,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Södertälje Curated by ChEMBL					Assay Description In vitro binding affinity at human cloned Dopamine receptor D2A measured by ability to displace [3H]-raclopride from D2A receptor expressed in mouse ...				J Med Chem 43: 2837-50 (2000) BindingDB Entry DOI: 10.7270/Q2610ZJK
					More data for this Ligand-Target Pair

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