Compile Data Set for Download or QSAR

Found 642 hits with Last Name = 'rex' and Initial = 'k'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hepatocyte growth factor receptor [1078-1345,H1094R,L1272V] (Homo sapiens (Human))	BDBM24466 (1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...) Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(C)(C)O)n(-c5ccccc5)c4=O)nc3)ccnc2c1 Show InChI InChI=1S/C30H29N5O5/c1-19-27(29(37)35(20-8-6-5-7-9-20)34(19)18-30(2,3)38)28(36)33-26-13-11-22(17-32-26)40-25-14-15-31-24-16-21(39-4)10-12-23(24)25/h5-17,38H,18H2,1-4H3,(H,32,33,36)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article PubMed	0.5	-52.6	n/a	n/a	n/a	n/a	n/a	7.4	22
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 3688-91 (2008) Article DOI: 10.1021/jm800401t BindingDB Entry DOI: 10.7270/Q2FF3QNG
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50383191 (CHEMBL2031893) Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4c(C)n(C)n(-c5ccccc5)c4=O)cc3F)c2cc1OC Show InChI InChI=1S/C29H25FN4O5/c1-17-27(29(36)34(33(17)2)19-8-6-5-7-9-19)28(35)32-18-10-11-24(21(30)14-18)39-23-12-13-31-22-16-26(38-4)25(37-3)15-20(22)23/h5-16H,1-4H3,(H,32,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant c-met-mediated gastrin phosphorylation by HTRF assay				J Med Chem 55: 1858-67 (2012) Article DOI: 10.1021/jm201330u BindingDB Entry DOI: 10.7270/Q2ZK5HQP
					More data for this Ligand-Target Pair				3D Structure (crystal)
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM24459 (N-{3-fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl}...) Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(C)n(-c5ccccc5)c4=O)cc3F)ccnc2c1 Show InChI InChI=1S/C28H23FN4O4/c1-17-26(28(35)33(32(17)2)19-7-5-4-6-8-19)27(34)31-18-9-12-25(22(29)15-18)37-24-13-14-30-23-16-20(36-3)10-11-21(23)24/h4-16H,1-3H3,(H,31,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	1	-50.9	n/a	n/a	n/a	n/a	n/a	7.4	22
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 3688-91 (2008) Article DOI: 10.1021/jm800401t BindingDB Entry DOI: 10.7270/Q2FF3QNG
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM24462 (N-{3-fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl}...) Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(C[C@@H](C)O)n(-c5ccccc5)c4=O)cc3F)ccnc2c1 |r| Show InChI InChI=1S/C30H27FN4O5/c1-18(36)17-34-19(2)28(30(38)35(34)21-7-5-4-6-8-21)29(37)33-20-9-12-27(24(31)15-20)40-26-13-14-32-25-16-22(39-3)10-11-23(25)26/h4-16,18,36H,17H2,1-3H3,(H,33,37)/t18-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	1	-50.9	n/a	n/a	n/a	n/a	n/a	7.4	22
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 3688-91 (2008) Article DOI: 10.1021/jm800401t BindingDB Entry DOI: 10.7270/Q2FF3QNG
					More data for this Ligand-Target Pair				3D Structure (crystal)
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM24460 (N-{3-fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl}...) Show SMILES CCCn1c(C)c(C(=O)Nc2ccc(Oc3ccnc4cc(OC)ccc34)c(F)c2)c(=O)n1-c1ccccc1 Show InChI InChI=1S/C30H27FN4O4/c1-4-16-34-19(2)28(30(37)35(34)21-8-6-5-7-9-21)29(36)33-20-10-13-27(24(31)17-20)39-26-14-15-32-25-18-22(38-3)11-12-23(25)26/h5-15,17-18H,4,16H2,1-3H3,(H,33,36)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	1.02	-50.8	n/a	n/a	n/a	n/a	n/a	7.4	22
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 3688-91 (2008) Article DOI: 10.1021/jm800401t BindingDB Entry DOI: 10.7270/Q2FF3QNG
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor [1078-1345,V1092I,L1272V] (Homo sapiens (Human))	BDBM24466 (1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...) Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(C)(C)O)n(-c5ccccc5)c4=O)nc3)ccnc2c1 Show InChI InChI=1S/C30H29N5O5/c1-19-27(29(37)35(20-8-6-5-7-9-20)34(19)18-30(2,3)38)28(36)33-26-13-11-22(17-32-26)40-25-14-15-31-24-16-21(39-4)10-12-23(24)25/h5-17,38H,18H2,1-4H3,(H,32,33,36)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article PubMed	1.10	-50.6	n/a	n/a	n/a	n/a	n/a	7.4	22
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 3688-91 (2008) Article DOI: 10.1021/jm800401t BindingDB Entry DOI: 10.7270/Q2FF3QNG
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM24463 (N-{3-fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl}...) Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(C[C@H](C)O)n(-c5ccccc5)c4=O)cc3F)ccnc2c1 |r| Show InChI InChI=1S/C30H27FN4O5/c1-18(36)17-34-19(2)28(30(38)35(34)21-7-5-4-6-8-21)29(37)33-20-9-12-27(24(31)15-20)40-26-13-14-32-25-16-22(39-3)10-11-23(25)26/h4-16,18,36H,17H2,1-3H3,(H,33,37)/t18-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	1.10	-50.6	n/a	n/a	n/a	n/a	n/a	7.4	22
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 3688-91 (2008) Article DOI: 10.1021/jm800401t BindingDB Entry DOI: 10.7270/Q2FF3QNG
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM24466 (1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...) Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(C)(C)O)n(-c5ccccc5)c4=O)nc3)ccnc2c1 Show InChI InChI=1S/C30H29N5O5/c1-19-27(29(37)35(20-8-6-5-7-9-20)34(19)18-30(2,3)38)28(36)33-26-13-11-22(17-32-26)40-25-14-15-31-24-16-21(39-4)10-12-23(24)25/h5-17,38H,18H2,1-4H3,(H,32,33,36)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article PubMed	1.20	-50.4	n/a	n/a	n/a	n/a	n/a	7.4	22
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 3688-91 (2008) Article DOI: 10.1021/jm800401t BindingDB Entry DOI: 10.7270/Q2FF3QNG
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM24464 (N-{3-fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl}...) Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(C)=O)n(-c5ccccc5)c4=O)cc3F)ccnc2c1 Show InChI InChI=1S/C30H25FN4O5/c1-18(36)17-34-19(2)28(30(38)35(34)21-7-5-4-6-8-21)29(37)33-20-9-12-27(24(31)15-20)40-26-13-14-32-25-16-22(39-3)10-11-23(25)26/h4-16H,17H2,1-3H3,(H,33,37)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	1.30	-50.2	n/a	n/a	n/a	n/a	n/a	7.4	22
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 3688-91 (2008) Article DOI: 10.1021/jm800401t BindingDB Entry DOI: 10.7270/Q2FF3QNG
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50299777 (CHEMBL573761 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...) Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)c2cc1OC Show InChI InChI=1S/C27H23FN4O5/c1-35-24-15-19-21(16-25(24)36-2)29-11-10-22(19)37-23-9-8-17(14-20(23)28)30-26(33)32-13-12-31(27(32)34)18-6-4-3-5-7-18/h3-11,14-16H,12-13H2,1-2H3,(H,30,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant c-met-mediated gastrin phosphorylation by HTRF assay				J Med Chem 55: 1858-67 (2012) Article DOI: 10.1021/jm201330u BindingDB Entry DOI: 10.7270/Q2ZK5HQP
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM24464 (N-{3-fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl}...) Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(C)=O)n(-c5ccccc5)c4=O)cc3F)ccnc2c1 Show InChI InChI=1S/C30H25FN4O5/c1-18(36)17-34-19(2)28(30(38)35(34)21-7-5-4-6-8-21)29(37)33-20-9-12-27(24(31)15-20)40-26-13-14-32-25-16-22(39-3)10-11-23(25)26/h4-16H,17H2,1-3H3,(H,33,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	2	-49.2	n/a	n/a	n/a	n/a	n/a	7.4	22
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 3688-91 (2008) Article DOI: 10.1021/jm800401t BindingDB Entry DOI: 10.7270/Q2FF3QNG
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Mus musculus)	BDBM24466 (1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...) Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(C)(C)O)n(-c5ccccc5)c4=O)nc3)ccnc2c1 Show InChI InChI=1S/C30H29N5O5/c1-19-27(29(37)35(20-8-6-5-7-9-20)34(19)18-30(2,3)38)28(36)33-26-13-11-22(17-32-26)40-25-14-15-31-24-16-21(39-4)10-12-23(24)25/h5-17,38H,18H2,1-4H3,(H,32,33,36)	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article PubMed	2	-49.2	n/a	n/a	n/a	n/a	n/a	7.4	22
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 3688-91 (2008) Article DOI: 10.1021/jm800401t BindingDB Entry DOI: 10.7270/Q2FF3QNG
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor [1078-1345,D1228H,L1272V] (Homo sapiens (Human))	BDBM24466 (1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...) Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(C)(C)O)n(-c5ccccc5)c4=O)nc3)ccnc2c1 Show InChI InChI=1S/C30H29N5O5/c1-19-27(29(37)35(20-8-6-5-7-9-20)34(19)18-30(2,3)38)28(36)33-26-13-11-22(17-32-26)40-25-14-15-31-24-16-21(39-4)10-12-23(24)25/h5-17,38H,18H2,1-4H3,(H,32,33,36)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article PubMed	2.20	-48.9	n/a	n/a	n/a	n/a	n/a	7.4	22
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 3688-91 (2008) Article DOI: 10.1021/jm800401t BindingDB Entry DOI: 10.7270/Q2FF3QNG
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM24465 (N-{3-fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl}...) Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(C)(C)O)n(-c5ccccc5)c4=O)cc3F)ccnc2c1 Show InChI InChI=1S/C31H29FN4O5/c1-19-28(30(38)36(21-8-6-5-7-9-21)35(19)18-31(2,3)39)29(37)34-20-10-13-27(24(32)16-20)41-26-14-15-33-25-17-22(40-4)11-12-23(25)26/h5-17,39H,18H2,1-4H3,(H,34,37)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	2.70	-48.4	n/a	n/a	n/a	n/a	n/a	7.4	22
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 3688-91 (2008) Article DOI: 10.1021/jm800401t BindingDB Entry DOI: 10.7270/Q2FF3QNG
					More data for this Ligand-Target Pair				3D Structure (crystal)
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM24772 (2-[(4-fluorophenyl)amino]-5-[5-({6-methoxy-7-[3-(m...) Show SMILES COc1cc2c(Oc3ccc(nc3)-c3cnc(Nc4ccc(F)cc4)n(C)c3=O)ccnc2cc1OCCCN1CCOCC1 Show InChI InChI=1S/C33H33FN6O5/c1-39-32(41)26(21-37-33(39)38-23-6-4-22(34)5-7-23)27-9-8-24(20-36-27)45-29-10-11-35-28-19-31(30(42-2)18-25(28)29)44-15-3-12-40-13-16-43-17-14-40/h4-11,18-21H,3,12-17H2,1-2H3,(H,37,38)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	3.40	-47.8	n/a	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 5766-79 (2008) Article DOI: 10.1021/jm8006189 BindingDB Entry DOI: 10.7270/Q23X84XN
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM24485 (3-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophe...) Show SMILES COc1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)c2cc1OC Show InChI InChI=1S/C26H22FN3O4S/c1-32-23-14-18-20(15-24(23)33-2)28-11-10-21(18)34-22-9-8-17(13-19(22)27)29-26(35)30-25(31)12-16-6-4-3-5-7-16/h3-11,13-15H,12H2,1-2H3,(H2,29,30,31,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant c-met-mediated gastrin phosphorylation by HTRF assay				J Med Chem 55: 1858-67 (2012) Article DOI: 10.1021/jm201330u BindingDB Entry DOI: 10.7270/Q2ZK5HQP
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor [1078-1345,M1250T,L1272V] (Homo sapiens (Human))	BDBM24466 (1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...) Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(C)(C)O)n(-c5ccccc5)c4=O)nc3)ccnc2c1 Show InChI InChI=1S/C30H29N5O5/c1-19-27(29(37)35(20-8-6-5-7-9-20)34(19)18-30(2,3)38)28(36)33-26-13-11-22(17-32-26)40-25-14-15-31-24-16-21(39-4)10-12-23(24)25/h5-17,38H,18H2,1-4H3,(H,32,33,36)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article PubMed	4.10	-47.4	n/a	n/a	n/a	n/a	n/a	7.4	22
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 3688-91 (2008) Article DOI: 10.1021/jm800401t BindingDB Entry DOI: 10.7270/Q2FF3QNG
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor [1078-1345,Y1230H,L1272V] (Homo sapiens (Human))	BDBM24466 (1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...) Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(C)(C)O)n(-c5ccccc5)c4=O)nc3)ccnc2c1 Show InChI InChI=1S/C30H29N5O5/c1-19-27(29(37)35(20-8-6-5-7-9-20)34(19)18-30(2,3)38)28(36)33-26-13-11-22(17-32-26)40-25-14-15-31-24-16-21(39-4)10-12-23(24)25/h5-17,38H,18H2,1-4H3,(H,32,33,36)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article PubMed	4.5	-47.2	n/a	n/a	n/a	n/a	n/a	7.4	22
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 3688-91 (2008) Article DOI: 10.1021/jm800401t BindingDB Entry DOI: 10.7270/Q2FF3QNG
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50383215 (CHEMBL2032039) Show SMILES COc1ccc2c(OCc3nnc4ccc(cn34)-c3cc(F)c(F)c(F)c3)ccnc2c1 Show InChI InChI=1S/C23H15F3N4O2/c1-31-15-3-4-16-19(10-15)27-7-6-20(16)32-12-22-29-28-21-5-2-13(11-30(21)22)14-8-17(24)23(26)18(25)9-14/h2-11H,12H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant c-met-mediated gastrin phosphorylation by HTRF assay				J Med Chem 55: 1858-67 (2012) Article DOI: 10.1021/jm201330u BindingDB Entry DOI: 10.7270/Q2ZK5HQP
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM24769 (5-[3-fluoro-4-({6-methoxy-7-[3-(morpholin-4-yl)pro...) Show SMILES COc1cc2c(Oc3ccc(cc3F)-c3cnc(Nc4ccc(F)cc4)n(C)c3=O)ccnc2cc1OCCCN1CCOCC1 Show InChI InChI=1S/C34H33F2N5O5/c1-40-33(42)26(21-38-34(40)39-24-7-5-23(35)6-8-24)22-4-9-30(27(36)18-22)46-29-10-11-37-28-20-32(31(43-2)19-25(28)29)45-15-3-12-41-13-16-44-17-14-41/h4-11,18-21H,3,12-17H2,1-2H3,(H,38,39)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	4.90	-47.0	n/a	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 5766-79 (2008) Article DOI: 10.1021/jm8006189 BindingDB Entry DOI: 10.7270/Q23X84XN
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM24461 (N-{3-fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl}...) Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(C)C)n(-c5ccccc5)c4=O)cc3F)ccnc2c1 Show InChI InChI=1S/C31H29FN4O4/c1-19(2)18-35-20(3)29(31(38)36(35)22-8-6-5-7-9-22)30(37)34-21-10-13-28(25(32)16-21)40-27-14-15-33-26-17-23(39-4)11-12-24(26)27/h5-17,19H,18H2,1-4H3,(H,34,37)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	8	-45.7	n/a	n/a	n/a	n/a	n/a	7.4	22
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 3688-91 (2008) Article DOI: 10.1021/jm800401t BindingDB Entry DOI: 10.7270/Q2FF3QNG
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM24751 (2-benzyl-5-[3-fluoro-4-({6-methoxy-7-[3-(morpholin...) Show SMILES COc1cc2c(Oc3ccc(cc3F)-c3cnc(Cc4ccccc4)n(C)c3=O)ccnc2cc1OCCCN1CCOCC1 Show InChI InChI=1S/C35H35FN4O5/c1-39-34(19-24-7-4-3-5-8-24)38-23-27(35(39)41)25-9-10-31(28(36)20-25)45-30-11-12-37-29-22-33(32(42-2)21-26(29)30)44-16-6-13-40-14-17-43-18-15-40/h3-5,7-12,20-23H,6,13-19H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	8.90	-45.5	n/a	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 5766-79 (2008) Article DOI: 10.1021/jm8006189 BindingDB Entry DOI: 10.7270/Q23X84XN
					More data for this Ligand-Target Pair				3D Structure (crystal)
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM24754 (2-benzyl-5-[3-fluoro-4-({6-methoxy-7-[3-(4-methylp...) Show SMILES COc1cc2c(Oc3ccc(cc3F)-c3cnc(Cc4ccccc4)n(C)c3=O)ccnc2cc1OCCCN1CCN(C)CC1 Show InChI InChI=1S/C36H38FN5O4/c1-40-15-17-42(18-16-40)14-7-19-45-34-23-30-27(22-33(34)44-3)31(12-13-38-30)46-32-11-10-26(21-29(32)37)28-24-39-35(41(2)36(28)43)20-25-8-5-4-6-9-25/h4-6,8-13,21-24H,7,14-20H2,1-3H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	9.20	-45.4	n/a	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 5766-79 (2008) Article DOI: 10.1021/jm8006189 BindingDB Entry DOI: 10.7270/Q23X84XN
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM24764 (5-[3-fluoro-4-({6-methoxy-7-[3-(morpholin-4-yl)pro...) Show SMILES COc1cc2c(Oc3ccc(cc3F)-c3cnc(Cc4ccc(C)cc4)n(C)c3=O)ccnc2cc1OCCCN1CCOCC1 Show InChI InChI=1S/C36H37FN4O5/c1-24-5-7-25(8-6-24)19-35-39-23-28(36(42)40(35)2)26-9-10-32(29(37)20-26)46-31-11-12-38-30-22-34(33(43-3)21-27(30)31)45-16-4-13-41-14-17-44-18-15-41/h5-12,20-23H,4,13-19H2,1-3H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	9.60	-45.3	n/a	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 5766-79 (2008) Article DOI: 10.1021/jm8006189 BindingDB Entry DOI: 10.7270/Q23X84XN
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM24752 (2-benzyl-5-[3-fluoro-4-({6-methoxy-7-[3-(pyrrolidi...) Show SMILES COc1cc2c(Oc3ccc(cc3F)-c3cnc(Cc4ccccc4)n(C)c3=O)ccnc2cc1OCCCN1CCCC1 Show InChI InChI=1S/C35H35FN4O4/c1-39-34(19-24-9-4-3-5-10-24)38-23-27(35(39)41)25-11-12-31(28(36)20-25)44-30-13-14-37-29-22-33(32(42-2)21-26(29)30)43-18-8-17-40-15-6-7-16-40/h3-5,9-14,20-23H,6-8,15-19H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	12	-44.8	n/a	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 5766-79 (2008) Article DOI: 10.1021/jm8006189 BindingDB Entry DOI: 10.7270/Q23X84XN
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50383209 (CHEMBL2032033) Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)C4CCN(C4=O)c4ccccc4)cc3F)c2cc1OC Show InChI InChI=1S/C28H24FN3O5/c1-35-25-15-20-22(16-26(25)36-2)30-12-10-23(20)37-24-9-8-17(14-21(24)29)31-27(33)19-11-13-32(28(19)34)18-6-4-3-5-7-18/h3-10,12,14-16,19H,11,13H2,1-2H3,(H,31,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	13.7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant c-met-mediated gastrin phosphorylation by HTRF assay				J Med Chem 55: 1858-67 (2012) Article DOI: 10.1021/jm201330u BindingDB Entry DOI: 10.7270/Q2ZK5HQP
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM24768 (5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophe...) Show SMILES COc1cc2nccc(Oc3ccc(cc3F)-c3cnc(Nc4ccc(F)cc4)n(C)c3=O)c2cc1OC Show InChI InChI=1S/C28H22F2N4O4/c1-34-27(35)20(15-32-28(34)33-18-7-5-17(29)6-8-18)16-4-9-24(21(30)12-16)38-23-10-11-31-22-14-26(37-3)25(36-2)13-19(22)23/h4-15H,1-3H3,(H,32,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	14	-44.4	n/a	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 5766-79 (2008) Article DOI: 10.1021/jm8006189 BindingDB Entry DOI: 10.7270/Q23X84XN
					More data for this Ligand-Target Pair				3D Structure (crystal)
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM24766 (5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophe...) Show SMILES COc1cc2nccc(Oc3ccc(cc3F)-c3cnc(Nc4ccccc4)n(C)c3=O)c2cc1OC Show InChI InChI=1S/C28H23FN4O4/c1-33-27(34)20(16-31-28(33)32-18-7-5-4-6-8-18)17-9-10-24(21(29)13-17)37-23-11-12-30-22-15-26(36-3)25(35-2)14-19(22)23/h4-16H,1-3H3,(H,31,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant c-met-mediated gastrin phosphorylation by HTRF assay				J Med Chem 55: 1858-67 (2012) Article DOI: 10.1021/jm201330u BindingDB Entry DOI: 10.7270/Q2ZK5HQP
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM24765 (5-[3-fluoro-4-({6-methoxy-7-[3-(morpholin-4-yl)pro...) Show SMILES COc1cc2c(Oc3ccc(cc3F)-c3cnc(Cc4ccc(F)cc4)n(C)c3=O)ccnc2cc1OCCCN1CCOCC1 Show InChI InChI=1S/C35H34F2N4O5/c1-40-34(18-23-4-7-25(36)8-5-23)39-22-27(35(40)42)24-6-9-31(28(37)19-24)46-30-10-11-38-29-21-33(32(43-2)20-26(29)30)45-15-3-12-41-13-16-44-17-14-41/h4-11,19-22H,3,12-18H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	17	-43.9	n/a	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 5766-79 (2008) Article DOI: 10.1021/jm8006189 BindingDB Entry DOI: 10.7270/Q23X84XN
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM24755 (2-benzyl-5-[4-({7-[3-(4-ethylpiperazin-1-yl)propox...) Show SMILES CCN1CCN(CCCOc2cc3nccc(Oc4ccc(cc4F)-c4cnc(Cc5ccccc5)n(C)c4=O)c3cc2OC)CC1 Show InChI InChI=1S/C37H40FN5O4/c1-4-42-16-18-43(19-17-42)15-8-20-46-35-24-31-28(23-34(35)45-3)32(13-14-39-31)47-33-12-11-27(22-30(33)38)29-25-40-36(41(2)37(29)44)21-26-9-6-5-7-10-26/h5-7,9-14,22-25H,4,8,15-21H2,1-3H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	21	-43.4	n/a	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 5766-79 (2008) Article DOI: 10.1021/jm8006189 BindingDB Entry DOI: 10.7270/Q23X84XN
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM24459 (N-{3-fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl}...) Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(C)n(-c5ccccc5)c4=O)cc3F)ccnc2c1 Show InChI InChI=1S/C28H23FN4O4/c1-17-26(28(35)33(32(17)2)19-7-5-4-6-8-19)27(34)31-18-9-12-25(22(29)15-18)37-24-13-14-30-23-16-20(36-3)10-11-21(23)24/h4-16H,1-3H3,(H,31,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	24	-43.1	n/a	n/a	n/a	n/a	n/a	7.4	22
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 3688-91 (2008) Article DOI: 10.1021/jm800401t BindingDB Entry DOI: 10.7270/Q2FF3QNG
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM24753 (2-benzyl-5-[3-fluoro-4-({6-methoxy-7-[3-(1H-1,2,4-...) Show SMILES COc1cc2c(Oc3ccc(cc3F)-c3cnc(Cc4ccccc4)n(C)c3=O)ccnc2cc1OCCCn1cncn1 Show InChI InChI=1S/C33H29FN6O4/c1-39-32(15-22-7-4-3-5-8-22)37-19-25(33(39)41)23-9-10-29(26(34)16-23)44-28-11-12-36-27-18-31(30(42-2)17-24(27)28)43-14-6-13-40-21-35-20-38-40/h3-5,7-12,16-21H,6,13-15H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	29	-42.6	n/a	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 5766-79 (2008) Article DOI: 10.1021/jm8006189 BindingDB Entry DOI: 10.7270/Q23X84XN
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM24760 (N-[(5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluor...) Show SMILES COc1cc2nccc(Oc3ccc(cc3F)-c3cnc(C(NC(=O)CN(C)C)c4ccccc4)n(C)c3=O)c2cc1OC Show InChI InChI=1S/C33H32FN5O5/c1-38(2)19-30(40)37-31(20-9-7-6-8-10-20)32-36-18-23(33(41)39(32)3)21-11-12-27(24(34)15-21)44-26-13-14-35-25-17-29(43-5)28(42-4)16-22(25)26/h6-18,31H,19H2,1-5H3,(H,37,40)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	30	-42.5	n/a	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 5766-79 (2008) Article DOI: 10.1021/jm8006189 BindingDB Entry DOI: 10.7270/Q23X84XN
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM24756 (2-benzyl-5-[3-fluoro-4-({7-[3-(4-hydroxypiperidin-...) Show SMILES COc1cc2c(Oc3ccc(cc3F)-c3cnc(Cc4ccccc4)n(C)c3=O)ccnc2cc1OCCCN1CCC(O)CC1 Show InChI InChI=1S/C36H37FN4O5/c1-40-35(19-24-7-4-3-5-8-24)39-23-28(36(40)43)25-9-10-32(29(37)20-25)46-31-11-14-38-30-22-34(33(44-2)21-27(30)31)45-18-6-15-41-16-12-26(42)13-17-41/h3-5,7-11,14,20-23,26,42H,6,12-13,15-19H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	33	-42.3	n/a	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 5766-79 (2008) Article DOI: 10.1021/jm8006189 BindingDB Entry DOI: 10.7270/Q23X84XN
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50383213 (CHEMBL2032037) Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)N4CCC(Cc5ccccc5)C4=O)cc3F)c2cc1OC Show InChI InChI=1S/C29H26FN3O5/c1-36-26-16-21-23(17-27(26)37-2)31-12-10-24(21)38-25-9-8-20(15-22(25)30)32-29(35)33-13-11-19(28(33)34)14-18-6-4-3-5-7-18/h3-10,12,15-17,19H,11,13-14H2,1-2H3,(H,32,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	37.8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant c-met-mediated gastrin phosphorylation by HTRF assay				J Med Chem 55: 1858-67 (2012) Article DOI: 10.1021/jm201330u BindingDB Entry DOI: 10.7270/Q2ZK5HQP
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM24770 (5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophe...) Show SMILES COc1cc2nccc(Oc3ccc(cc3F)-c3cnc(Nc4cccc(F)c4)n(C)c3=O)c2cc1OC Show InChI InChI=1S/C28H22F2N4O4/c1-34-27(35)20(15-32-28(34)33-18-6-4-5-17(29)12-18)16-7-8-24(21(30)11-16)38-23-9-10-31-22-14-26(37-3)25(36-2)13-19(22)23/h4-15H,1-3H3,(H,32,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	38	-41.9	n/a	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 5766-79 (2008) Article DOI: 10.1021/jm8006189 BindingDB Entry DOI: 10.7270/Q23X84XN
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM24750 (2-benzyl-5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-...) Show SMILES COc1cc2nccc(Oc3ccc(cc3F)-c3cnc(Cc4ccccc4)n(C)c3=O)c2cc1OC Show InChI InChI=1S/C29H24FN3O4/c1-33-28(13-18-7-5-4-6-8-18)32-17-21(29(33)34)19-9-10-25(22(30)14-19)37-24-11-12-31-23-16-27(36-3)26(35-2)15-20(23)24/h4-12,14-17H,13H2,1-3H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	39	-41.9	n/a	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 5766-79 (2008) Article DOI: 10.1021/jm8006189 BindingDB Entry DOI: 10.7270/Q23X84XN
					More data for this Ligand-Target Pair				3D Structure (crystal)
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM24767 (5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophe...) Show SMILES COc1cc2nccc(Oc3ccc(cc3F)-c3cnc(Nc4ccccc4F)n(C)c3=O)c2cc1OC Show InChI InChI=1S/C28H22F2N4O4/c1-34-27(35)18(15-32-28(34)33-21-7-5-4-6-19(21)29)16-8-9-24(20(30)12-16)38-23-10-11-31-22-14-26(37-3)25(36-2)13-17(22)23/h4-15H,1-3H3,(H,32,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	45	-41.5	n/a	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 5766-79 (2008) Article DOI: 10.1021/jm8006189 BindingDB Entry DOI: 10.7270/Q23X84XN
					More data for this Ligand-Target Pair
Sphingosine kinase 1 (Homo sapiens (Human))	BDBM50343835 ((S)-1-(4-(4-(3-(2-Cyclohexylethyl)phenyl)oxazol-2-...) Show SMILES NC(=N)[C@@H]1CCCN1C(=O)c1ccc(cc1)-c1nc(co1)-c1cccc(CCC2CCCCC2)c1 |r| Show InChI InChI=1S/C29H34N4O2/c30-27(31)26-10-5-17-33(26)29(34)23-15-13-22(14-16-23)28-32-25(19-35-28)24-9-4-8-21(18-24)12-11-20-6-2-1-3-7-20/h4,8-9,13-16,18-20,26H,1-3,5-7,10-12,17H2,(H3,30,31)/t26-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	50	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation counting				Bioorg Med Chem Lett 23: 4608-16 (2013) Article DOI: 10.1016/j.bmcl.2013.06.030 BindingDB Entry DOI: 10.7270/Q2736SB3
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM24762 (N-[(5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluor...) Show SMILES COc1cc2nccc(Oc3ccc(cc3F)-c3cnc(C(NC(=O)CCSC)c4ccccc4)n(C)c3=O)c2cc1OC Show InChI InChI=1S/C33H31FN4O5S/c1-38-32(31(20-8-6-5-7-9-20)37-30(39)13-15-44-4)36-19-23(33(38)40)21-10-11-27(24(34)16-21)43-26-12-14-35-25-18-29(42-3)28(41-2)17-22(25)26/h5-12,14,16-19,31H,13,15H2,1-4H3,(H,37,39)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	52	-41.2	n/a	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 5766-79 (2008) Article DOI: 10.1021/jm8006189 BindingDB Entry DOI: 10.7270/Q23X84XN
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50383210 (CHEMBL2032034) Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)C4(C)CCN(C4=O)c4ccccc4)cc3F)c2cc1OC Show InChI InChI=1S/C29H26FN3O5/c1-29(12-14-33(28(29)35)19-7-5-4-6-8-19)27(34)32-18-9-10-24(21(30)15-18)38-23-11-13-31-22-17-26(37-3)25(36-2)16-20(22)23/h4-11,13,15-17H,12,14H2,1-3H3,(H,32,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	56.7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant c-met-mediated gastrin phosphorylation by HTRF assay				J Med Chem 55: 1858-67 (2012) Article DOI: 10.1021/jm201330u BindingDB Entry DOI: 10.7270/Q2ZK5HQP
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50383212 (CHEMBL2032036) Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)C4CCN(Cc5ccccc5)C4=O)cc3F)c2cc1OC Show InChI InChI=1S/C29H26FN3O5/c1-36-26-15-21-23(16-27(26)37-2)31-12-10-24(21)38-25-9-8-19(14-22(25)30)32-28(34)20-11-13-33(29(20)35)17-18-6-4-3-5-7-18/h3-10,12,14-16,20H,11,13,17H2,1-2H3,(H,32,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	60.2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant c-met-mediated gastrin phosphorylation by HTRF assay				J Med Chem 55: 1858-67 (2012) Article DOI: 10.1021/jm201330u BindingDB Entry DOI: 10.7270/Q2ZK5HQP
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM24766 (5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophe...) Show SMILES COc1cc2nccc(Oc3ccc(cc3F)-c3cnc(Nc4ccccc4)n(C)c3=O)c2cc1OC Show InChI InChI=1S/C28H23FN4O4/c1-33-27(34)20(16-31-28(33)32-18-7-5-4-6-8-18)17-9-10-24(21(29)13-17)37-23-11-12-30-22-15-26(36-3)25(35-2)14-19(22)23/h4-16H,1-3H3,(H,31,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	63	-40.7	n/a	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 5766-79 (2008) Article DOI: 10.1021/jm8006189 BindingDB Entry DOI: 10.7270/Q23X84XN
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM24761 (N-[(5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluor...) Show SMILES CCC(=O)NC(c1ccccc1)c1ncc(-c2ccc(Oc3ccnc4cc(OC)c(OC)cc34)c(F)c2)c(=O)n1C Show InChI InChI=1S/C32H29FN4O5/c1-5-29(38)36-30(19-9-7-6-8-10-19)31-35-18-22(32(39)37(31)2)20-11-12-26(23(33)15-20)42-25-13-14-34-24-17-28(41-4)27(40-3)16-21(24)25/h6-18,30H,5H2,1-4H3,(H,36,38)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	71	-40.4	n/a	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 5766-79 (2008) Article DOI: 10.1021/jm8006189 BindingDB Entry DOI: 10.7270/Q23X84XN
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM24759 (2-[amino(phenyl)methyl]-5-{4-[(6,7-dimethoxyquinol...) Show SMILES COc1cc2nccc(Oc3ccc(cc3F)-c3cnc(C(N)c4ccccc4)n(C)c3=O)c2cc1OC Show InChI InChI=1S/C29H25FN4O4/c1-34-28(27(31)17-7-5-4-6-8-17)33-16-20(29(34)35)18-9-10-24(21(30)13-18)38-23-11-12-32-22-15-26(37-3)25(36-2)14-19(22)23/h4-16,27H,31H2,1-3H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	72	-40.4	n/a	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 5766-79 (2008) Article DOI: 10.1021/jm8006189 BindingDB Entry DOI: 10.7270/Q23X84XN
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM24772 (2-[(4-fluorophenyl)amino]-5-[5-({6-methoxy-7-[3-(m...) Show SMILES COc1cc2c(Oc3ccc(nc3)-c3cnc(Nc4ccc(F)cc4)n(C)c3=O)ccnc2cc1OCCCN1CCOCC1 Show InChI InChI=1S/C33H33FN6O5/c1-39-32(41)26(21-37-33(39)38-23-6-4-22(34)5-7-23)27-9-8-24(20-36-27)45-29-10-11-35-28-19-31(30(42-2)18-25(28)29)44-15-3-12-40-13-16-43-17-14-40/h4-11,18-21H,3,12-17H2,1-2H3,(H,37,38)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	83	-40.0	n/a	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 5766-79 (2008) Article DOI: 10.1021/jm8006189 BindingDB Entry DOI: 10.7270/Q23X84XN
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM24485 (3-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophe...) Show SMILES COc1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)c2cc1OC Show InChI InChI=1S/C26H22FN3O4S/c1-32-23-14-18-20(15-24(23)33-2)28-11-10-21(18)34-22-9-8-17(13-19(22)27)29-26(35)30-25(31)12-16-6-4-3-5-7-16/h3-11,13-15H,12H2,1-2H3,(H2,29,30,31,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	103	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of VEGFR2				J Med Chem 55: 1858-67 (2012) Article DOI: 10.1021/jm201330u BindingDB Entry DOI: 10.7270/Q2ZK5HQP
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM24757 (2-benzyl-5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-...) Show SMILES COc1cc2nccc(Oc3ccc(cc3F)-c3cnc(Cc4ccccc4)[nH]c3=O)c2cc1OC Show InChI InChI=1S/C28H22FN3O4/c1-34-25-14-19-22(15-26(25)35-2)30-11-10-23(19)36-24-9-8-18(13-21(24)29)20-16-31-27(32-28(20)33)12-17-6-4-3-5-7-17/h3-11,13-16H,12H2,1-2H3,(H,31,32,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	107	-39.4	n/a	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 5766-79 (2008) Article DOI: 10.1021/jm8006189 BindingDB Entry DOI: 10.7270/Q23X84XN
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM24771 (5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophe...) Show SMILES COc1cc2nccc(Oc3ccc(cc3F)-c3cnc(Nc4ccc(cc4)C(F)(F)F)n(C)c3=O)c2cc1OC Show InChI InChI=1S/C29H22F4N4O4/c1-37-27(38)20(15-35-28(37)36-18-7-5-17(6-8-18)29(31,32)33)16-4-9-24(21(30)12-16)41-23-10-11-34-22-14-26(40-3)25(39-2)13-19(22)23/h4-15H,1-3H3,(H,35,36)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	136	-38.8	n/a	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 5766-79 (2008) Article DOI: 10.1021/jm8006189 BindingDB Entry DOI: 10.7270/Q23X84XN
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM24769 (5-[3-fluoro-4-({6-methoxy-7-[3-(morpholin-4-yl)pro...) Show SMILES COc1cc2c(Oc3ccc(cc3F)-c3cnc(Nc4ccc(F)cc4)n(C)c3=O)ccnc2cc1OCCCN1CCOCC1 Show InChI InChI=1S/C34H33F2N5O5/c1-40-33(42)26(21-38-34(40)39-24-7-5-23(35)6-8-24)22-4-9-30(27(36)18-22)46-29-10-11-37-28-20-32(31(43-2)19-25(28)29)45-15-3-12-41-13-16-44-17-14-41/h4-11,18-21H,3,12-17H2,1-2H3,(H,38,39)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	139	-38.7	n/a	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 5766-79 (2008) Article DOI: 10.1021/jm8006189 BindingDB Entry DOI: 10.7270/Q23X84XN
					More data for this Ligand-Target Pair

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