Compile Data Set for Download or QSAR

Found 306 hits Enz. Inhib. hit(s) with Target = 'Thyrotropin-releasing hormone receptor'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Thyrotropin-releasing hormone receptor (MOUSE)	BDBM50050531 (1-[3-(1-methyl-4-imidazolyl)-2-[2-oxo-(5S)-dihydro...) Show SMILES Cn1cnc(C[C@H](NC(=O)[C@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)c1 Show InChI InChI=1S/C17H24N6O4/c1-22-8-10(19-9-22)7-12(21-16(26)11-4-5-14(24)20-11)17(27)23-6-2-3-13(23)15(18)25/h8-9,11-13H,2-7H2,1H3,(H2,18,25)(H,20,24)(H,21,26)/t11-,12+,13+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Washington University Curated by ChEMBL					Assay Description Binding affinity against TRH-R receptor in AtT-20 mouse pituitary tumor cells				J Med Chem 39: 1571-4 (1996) Article DOI: 10.1021/jm960053k BindingDB Entry DOI: 10.7270/Q2H70GGR
					More data for this Ligand-Target Pair
Thyrotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50196446 (CHEMBL224730 | [N tau(1)-Me-His]-TRH) Show SMILES C[n+]1c[nH]cc1C[C@H](N)C(=O)N1[C@@H](CCC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O Show InChI InChI=1S/C23H31N9O5/c1-30-12-27-10-14(30)8-15(24)22(36)32-18(4-5-19(32)33)21(35)29-16(7-13-9-26-11-28-13)23(37)31-6-2-3-17(31)20(25)34/h9-12,15-18H,2-8,24H2,1H3,(H4,25,26,28,29,34,35)/p+1/t15-,16-,17-,18-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Pharmaceutical Education and Research Curated by ChEMBL					Assay Description Displacement of [3H]N(1)-Me-His-TRH from TRHR1				Bioorg Med Chem 15: 433-43 (2006) Article DOI: 10.1016/j.bmc.2006.09.045 BindingDB Entry DOI: 10.7270/Q2ZW1KJV
					More data for this Ligand-Target Pair
Thyrotropin-releasing hormone receptor (Rattus norvegicus)	BDBM50173826 (1-[(S)-2-Amino-3-(3-methyl-3H-imidazol-4-yl)-propi...) Show SMILES Cn1cncc1C[C@H](N)C(=O)N1[C@@H](CCC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O Show InChI InChI=1S/C23H31N9O5/c1-30-12-27-10-14(30)8-15(24)22(36)32-18(4-5-19(32)33)21(35)29-16(7-13-9-26-11-28-13)23(37)31-6-2-3-17(31)20(25)34/h9-12,15-18H,2-8,24H2,1H3,(H2,25,34)(H,26,28)(H,29,35)/t15-,16-,17-,18-/m0/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
National Institute of Pharmaceutical Education and Research Curated by ChEMBL					Assay Description Inhibitory constant against thyrotropin releasing hormone receptor 1 expressed in HEK 293EM cells upon incubation at 37 degee C for 1 hr at pH 7.4 us...				J Med Chem 48: 6162-5 (2005) Article DOI: 10.1021/jm0505462 BindingDB Entry DOI: 10.7270/Q2PK0FQG
					More data for this Ligand-Target Pair
Thyrotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50196451 ((2S)-1-{(2S)-3-(1-methyl-1H-4-imidazolyl)-2-[(2S)-...) Show SMILES Cn1cnc(C[C@H](NC(=O)[C@@H]2CCCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)c1 Show InChI InChI=1S/C18H26N6O4/c1-23-9-11(20-10-23)8-13(18(28)24-7-3-5-14(24)16(19)26)22-17(27)12-4-2-6-15(25)21-12/h9-10,12-14H,2-8H2,1H3,(H2,19,26)(H,21,25)(H,22,27)/t12-,13-,14-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Pharmaceutical Education and Research Curated by ChEMBL					Assay Description Displacement of [3H]N(1)-Me-His-TRH from TRHR1				Bioorg Med Chem 15: 433-43 (2006) Article DOI: 10.1016/j.bmc.2006.09.045 BindingDB Entry DOI: 10.7270/Q2ZW1KJV
					More data for this Ligand-Target Pair
Thyrotropin-releasing hormone receptor (MOUSE)	BDBM50072394 (1-[3-(1H-4-imidazolyl)-2-(5-oxotetrahydro-1H-2-pyr...) Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1 |r| Show InChI InChI=1S/C16H22N6O4/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25)/t10-,11-,12-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase KEGG PC cid PC sid UniChem Similars	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Washington University Curated by ChEMBL					Assay Description Binding affinity against TRH-R receptor in AtT-20 mouse pituitary tumor cells				J Med Chem 39: 1571-4 (1996) Article DOI: 10.1021/jm960053k BindingDB Entry DOI: 10.7270/Q2H70GGR
					More data for this Ligand-Target Pair
Thyrotropin-releasing hormone receptor (Rattus norvegicus)	BDBM50072394 (1-[3-(1H-4-imidazolyl)-2-(5-oxotetrahydro-1H-2-pyr...) Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1 |r| Show InChI InChI=1S/C16H22N6O4/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25)/t10-,11-,12-/m0/s1	KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase KEGG PC cid PC sid UniChem Similars	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
National Institute of Pharmaceutical Education and Research Curated by ChEMBL					Assay Description Inhibitory constant against thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells upon incubation at 37 degee C for 1 hr at pH 7.4 us...				J Med Chem 48: 6162-5 (2005) Article DOI: 10.1021/jm0505462 BindingDB Entry DOI: 10.7270/Q2PK0FQG
					More data for this Ligand-Target Pair
Thyrotropin-releasing hormone receptor (Rattus norvegicus)	BDBM50072394 (1-[3-(1H-4-imidazolyl)-2-(5-oxotetrahydro-1H-2-pyr...) Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1 |r| Show InChI InChI=1S/C16H22N6O4/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25)/t10-,11-,12-/m0/s1	KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase KEGG PC cid PC sid UniChem Similars	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Pharmaceutical Education and Research Curated by ChEMBL					Assay Description Displacement of [3H]N(1)-Me-His-TRH from TRHR2				Bioorg Med Chem 15: 433-43 (2006) Article DOI: 10.1016/j.bmc.2006.09.045 BindingDB Entry DOI: 10.7270/Q2ZW1KJV
					More data for this Ligand-Target Pair
Thyrotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50196457 ((2S)-1-{(2S)-3-(1-ethyl-1H-4-imidazolyl)-2-[(2S)-6...) Show SMILES CCn1cnc(C[C@H](NC(=O)[C@@H]2CCCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)c1 Show InChI InChI=1S/C19H28N6O4/c1-2-24-10-12(21-11-24)9-14(19(29)25-8-4-6-15(25)17(20)27)23-18(28)13-5-3-7-16(26)22-13/h10-11,13-15H,2-9H2,1H3,(H2,20,27)(H,22,26)(H,23,28)/t13-,14-,15-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	11	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Pharmaceutical Education and Research Curated by ChEMBL					Assay Description Displacement of [3H]N(1)-Me-His-TRH from TRHR1				Bioorg Med Chem 15: 433-43 (2006) Article DOI: 10.1016/j.bmc.2006.09.045 BindingDB Entry DOI: 10.7270/Q2ZW1KJV
					More data for this Ligand-Target Pair
Thyrotropin-releasing hormone receptor (Rattus norvegicus)	BDBM50196451 ((2S)-1-{(2S)-3-(1-methyl-1H-4-imidazolyl)-2-[(2S)-...) Show SMILES Cn1cnc(C[C@H](NC(=O)[C@@H]2CCCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)c1 Show InChI InChI=1S/C18H26N6O4/c1-23-9-11(20-10-23)8-13(18(28)24-7-3-5-14(24)16(19)26)22-17(27)12-4-2-6-15(25)21-12/h9-10,12-14H,2-8H2,1H3,(H2,19,26)(H,21,25)(H,22,27)/t12-,13-,14-/m0/s1	KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	13	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Pharmaceutical Education and Research Curated by ChEMBL					Assay Description Displacement of [3H]N(1)-Me-His-TRH from TRHR2				Bioorg Med Chem 15: 433-43 (2006) Article DOI: 10.1016/j.bmc.2006.09.045 BindingDB Entry DOI: 10.7270/Q2ZW1KJV
					More data for this Ligand-Target Pair
Thyrotropin-releasing hormone receptor (MOUSE)	BDBM86214 (CAS_32281 | NSC_32281 | Phe2TRH | TRH) Show SMILES NC(=O)C1CCCN1C(=O)C(Cc1cnc[nH]1)NC(=O)C1CCC(=O)N1 Show InChI InChI=1S/C16H22N6O4/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Diabetes and Digestive and Kidney Diseases Curated by PDSP Ki Database									Endocrinology 144: 1842-6 (2003) Article DOI: 10.1210/en.2002-221074 BindingDB Entry DOI: 10.7270/Q2736PGN
					More data for this Ligand-Target Pair
Thyrotropin-releasing hormone receptor (Xenopus)	BDBM86214 (CAS_32281 | NSC_32281 | Phe2TRH | TRH) Show SMILES NC(=O)C1CCCN1C(=O)C(Cc1cnc[nH]1)NC(=O)C1CCC(=O)N1 Show InChI InChI=1S/C16H22N6O4/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25)	KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	17	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Diabetes and Digestive and Kidney Diseases Curated by PDSP Ki Database									Endocrinology 144: 1842-6 (2003) Article DOI: 10.1210/en.2002-221074 BindingDB Entry DOI: 10.7270/Q2736PGN
					More data for this Ligand-Target Pair
Thyrotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50072394 (1-[3-(1H-4-imidazolyl)-2-(5-oxotetrahydro-1H-2-pyr...) Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1 |r| Show InChI InChI=1S/C16H22N6O4/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25)/t10-,11-,12-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid UniChem Similars	Article PubMed	20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Pharmaceutical Education and Research Curated by ChEMBL					Assay Description Displacement of [3H]N(1)-Me-His-TRH from TRHR1				Bioorg Med Chem 15: 433-43 (2006) Article DOI: 10.1016/j.bmc.2006.09.045 BindingDB Entry DOI: 10.7270/Q2ZW1KJV
					More data for this Ligand-Target Pair
Thyrotropin-releasing hormone receptor (Rattus norvegicus)	BDBM50072394 (1-[3-(1H-4-imidazolyl)-2-(5-oxotetrahydro-1H-2-pyr...) Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1 |r| Show InChI InChI=1S/C16H22N6O4/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25)/t10-,11-,12-/m0/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase KEGG PC cid PC sid UniChem Similars	Article PubMed	20	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
National Institute of Pharmaceutical Education and Research Curated by ChEMBL					Assay Description Inhibitory constant against thyrotropin releasing hormone receptor 1 expressed in HEK 293EM cells upon incubation at 37 degee C for 1 hr at pH 7.4 us...				J Med Chem 48: 6162-5 (2005) Article DOI: 10.1021/jm0505462 BindingDB Entry DOI: 10.7270/Q2PK0FQG
					More data for this Ligand-Target Pair
Thyrotropin-releasing hormone receptor (MOUSE)	BDBM50072394 (1-[3-(1H-4-imidazolyl)-2-(5-oxotetrahydro-1H-2-pyr...) Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1 |r| Show InChI InChI=1S/C16H22N6O4/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25)/t10-,11-,12-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase KEGG PC cid PC sid UniChem Similars	Article PubMed	23	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Washington University Curated by ChEMBL					Assay Description Ability to bind thyroliberin endocrine receptor (TRH-R) using AtT-20 mouse pituitary tumor cells.				Bioorg Med Chem Lett 8: 3093-6 (1999) Article DOI: 10.1016/S0960-894X(98)00567-8 BindingDB Entry DOI: 10.7270/Q21R6PP1
					More data for this Ligand-Target Pair
Thyrotropin-releasing hormone receptor (Rattus norvegicus)	BDBM50196457 ((2S)-1-{(2S)-3-(1-ethyl-1H-4-imidazolyl)-2-[(2S)-6...) Show SMILES CCn1cnc(C[C@H](NC(=O)[C@@H]2CCCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)c1 Show InChI InChI=1S/C19H28N6O4/c1-2-24-10-12(21-11-24)9-14(19(29)25-8-4-6-15(25)17(20)27)23-18(28)13-5-3-7-16(26)22-13/h10-11,13-15H,2-9H2,1H3,(H2,20,27)(H,22,26)(H,23,28)/t13-,14-,15-/m0/s1	KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	34	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Pharmaceutical Education and Research Curated by ChEMBL					Assay Description Displacement of [3H]N(1)-Me-His-TRH from TRHR2				Bioorg Med Chem 15: 433-43 (2006) Article DOI: 10.1016/j.bmc.2006.09.045 BindingDB Entry DOI: 10.7270/Q2ZW1KJV
					More data for this Ligand-Target Pair
Thyrotropin-releasing hormone receptor (Rattus norvegicus)	BDBM50072394 (1-[3-(1H-4-imidazolyl)-2-(5-oxotetrahydro-1H-2-pyr...) Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1 |r| Show InChI InChI=1S/C16H22N6O4/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25)/t10-,11-,12-/m0/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase KEGG PC cid PC sid UniChem Similars	Article PubMed	42	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florida Curated by ChEMBL					Assay Description Inhibition of [3H]-[3-Me-His2]-TRH binding to thyrotropin releasing hormone receptor of rat forebrain				J Med Chem 47: 6025-33 (2004) Article DOI: 10.1021/jm020531t BindingDB Entry DOI: 10.7270/Q2W095F0
					More data for this Ligand-Target Pair
Thyrotropin-releasing hormone receptor (Rattus norvegicus)	BDBM50196445 ((2S)-1-[(2S)-2-(2S)-6-oxohexahydro-2-pyridinylcarb...) Show SMILES CCCc1ncc(C[C@H](NC(=O)[C@@H]2CCCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)[nH]1 Show InChI InChI=1S/C20H30N6O4/c1-2-5-16-22-11-12(23-16)10-14(20(30)26-9-4-7-15(26)18(21)28)25-19(29)13-6-3-8-17(27)24-13/h11,13-15H,2-10H2,1H3,(H2,21,28)(H,22,23)(H,24,27)(H,25,29)/t13-,14-,15-/m0/s1	KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	290	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Pharmaceutical Education and Research Curated by ChEMBL					Assay Description Displacement of [3H]N(1)-Me-His-TRH from TRHR2				Bioorg Med Chem 15: 433-43 (2006) Article DOI: 10.1016/j.bmc.2006.09.045 BindingDB Entry DOI: 10.7270/Q2ZW1KJV
					More data for this Ligand-Target Pair
Thyrotropin-releasing hormone receptor (Rattus norvegicus)	BDBM50173828 (1-[2-[5-oxo-(2S)-tetrahydro-1H-2-pyrrolylcarboxami...) Show SMILES CCCc1ncc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)[nH]1 Show InChI InChI=1S/C19H28N6O4/c1-2-4-15-21-10-11(22-15)9-13(24-18(28)12-6-7-16(26)23-12)19(29)25-8-3-5-14(25)17(20)27/h10,12-14H,2-9H2,1H3,(H2,20,27)(H,21,22)(H,23,26)(H,24,28)/t12-,13-,14-/m0/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	320	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
National Institute of Pharmaceutical Education and Research Curated by ChEMBL					Assay Description Inhibitory constant against thyrotropin releasing hormone receptor 1 expressed in HEK 293EM cells upon incubation at 37 degee C for 1 hr at pH 7.4 us...				J Med Chem 48: 6162-5 (2005) Article DOI: 10.1021/jm0505462 BindingDB Entry DOI: 10.7270/Q2PK0FQG
					More data for this Ligand-Target Pair
Thyrotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50196445 ((2S)-1-[(2S)-2-(2S)-6-oxohexahydro-2-pyridinylcarb...) Show SMILES CCCc1ncc(C[C@H](NC(=O)[C@@H]2CCCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)[nH]1 Show InChI InChI=1S/C20H30N6O4/c1-2-5-16-22-11-12(23-16)10-14(20(30)26-9-4-7-15(26)18(21)28)25-19(29)13-6-3-8-17(27)24-13/h11,13-15H,2-10H2,1H3,(H2,21,28)(H,22,23)(H,24,27)(H,25,29)/t13-,14-,15-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Pharmaceutical Education and Research Curated by ChEMBL					Assay Description Displacement of [3H]N(1)-Me-His-TRH from TRHR1				Bioorg Med Chem 15: 433-43 (2006) Article DOI: 10.1016/j.bmc.2006.09.045 BindingDB Entry DOI: 10.7270/Q2ZW1KJV
					More data for this Ligand-Target Pair
Thyrotropin-releasing hormone receptor (MOUSE)	BDBM50072396 (7-cyclohexyl-6-(2,6-dioxo-1,7-diazaspiro[4.4]non-7...) Show SMILES NC(=O)[C@@H]1CC[C@H]2CC(C3CCCCC3)=C(N3CC[C@]4(CCC(=O)N4)C3=O)C(=O)N12 |t:15| Show InChI InChI=1S/C22H30N4O4/c23-19(28)16-7-6-14-12-15(13-4-2-1-3-5-13)18(20(29)26(14)16)25-11-10-22(21(25)30)9-8-17(27)24-22/h13-14,16H,1-12H2,(H2,23,28)(H,24,27)/t14-,16-,22+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Washington University Curated by ChEMBL					Assay Description Ability to activate thyroliberin endocrine receptor (TRH-R) using AtT-20 mouse pituitary tumor cells prelabelled with myo-[3H] inositol				Bioorg Med Chem Lett 8: 3093-6 (1999) Article DOI: 10.1016/S0960-894X(98)00567-8 BindingDB Entry DOI: 10.7270/Q21R6PP1
					More data for this Ligand-Target Pair
Thyrotropin-releasing hormone receptor (MOUSE)	BDBM50050532 (1-[2-[2-oxo-(5S)-dihydro-2H-5-pyrrolylcarboxamido]...) Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCC(=O)N1 Show InChI InChI=1S/C19H24N4O4/c20-17(25)15-7-4-10-23(15)19(27)14(11-12-5-2-1-3-6-12)22-18(26)13-8-9-16(24)21-13/h1-3,5-6,13-15H,4,7-11H2,(H2,20,25)(H,21,24)(H,22,26)/t13-,14-,15-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Washington University Curated by ChEMBL					Assay Description Binding affinity against TRH-R receptor in AtT-20 mouse pituitary tumor cells				J Med Chem 39: 1571-4 (1996) Article DOI: 10.1021/jm960053k BindingDB Entry DOI: 10.7270/Q2H70GGR
					More data for this Ligand-Target Pair
Thyrotropin-releasing hormone receptor (Xenopus)	BDBM86217 (Desaza1TRH) Show SMILES NC(=O)C1CCCN1C(=O)C(Cc1cnc[nH]1)NC(=O)C1CCC(=O)C1 Show InChI InChI=1S/C17H23N5O4/c18-15(24)14-2-1-5-22(14)17(26)13(7-11-8-19-9-20-11)21-16(25)10-3-4-12(23)6-10/h8-10,13-14H,1-7H2,(H2,18,24)(H,19,20)(H,21,25)	KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Diabetes and Digestive and Kidney Diseases Curated by PDSP Ki Database									Endocrinology 144: 1842-6 (2003) Article DOI: 10.1210/en.2002-221074 BindingDB Entry DOI: 10.7270/Q2736PGN
					More data for this Ligand-Target Pair
Thyrotropin-releasing hormone receptor (MOUSE)	BDBM50050529 ((S)-1-[2-((5R,7R)-2,6-Dioxo-1,7-diaza-spiro[4.4]no...) Show SMILES NC(=O)[C@@H]1CCCN1C(=O)C(Cc1ccccc1)N1CC[C@]2(CCC(=O)N2)C1=O Show InChI InChI=1S/C21H26N4O4/c22-18(27)15-7-4-11-24(15)19(28)16(13-14-5-2-1-3-6-14)25-12-10-21(20(25)29)9-8-17(26)23-21/h1-3,5-6,15-16H,4,7-13H2,(H2,22,27)(H,23,26)/t15-,16?,21+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	4.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Washington University Curated by ChEMBL					Assay Description Binding affinity against TRH-R receptor in AtT-20 mouse pituitary tumor cells				J Med Chem 39: 1571-4 (1996) Article DOI: 10.1021/jm960053k BindingDB Entry DOI: 10.7270/Q2H70GGR
					More data for this Ligand-Target Pair
Thyrotropin-releasing hormone receptor (Xenopus)	BDBM86214 (CAS_32281 | NSC_32281 | Phe2TRH | TRH) Show SMILES NC(=O)C1CCCN1C(=O)C(Cc1cnc[nH]1)NC(=O)C1CCC(=O)N1 Show InChI InChI=1S/C16H22N6O4/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25)	KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	4.80E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Diabetes and Digestive and Kidney Diseases Curated by PDSP Ki Database									Endocrinology 144: 1842-6 (2003) Article DOI: 10.1210/en.2002-221074 BindingDB Entry DOI: 10.7270/Q2736PGN
					More data for this Ligand-Target Pair
Thyrotropin-releasing hormone receptor (MOUSE)	BDBM86214 (CAS_32281 | NSC_32281 | Phe2TRH | TRH) Show SMILES NC(=O)C1CCCN1C(=O)C(Cc1cnc[nH]1)NC(=O)C1CCC(=O)N1 Show InChI InChI=1S/C16H22N6O4/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	5.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Diabetes and Digestive and Kidney Diseases Curated by PDSP Ki Database									Endocrinology 144: 1842-6 (2003) Article DOI: 10.1210/en.2002-221074 BindingDB Entry DOI: 10.7270/Q2736PGN
					More data for this Ligand-Target Pair
Thyrotropin-releasing hormone receptor (MOUSE)	BDBM50072395 (1-[3-cyclohexyl-2-(5-oxotetrahydro-1H-2-pyrrolylca...) Show SMILES [H][C@]1(CCC(=O)N1)C(=O)N[C@@H](CC1CCCCC1)C(=O)N1CCC[C@H]1C(N)=O Show InChI InChI=1S/C19H30N4O4/c20-17(25)15-7-4-10-23(15)19(27)14(11-12-5-2-1-3-6-12)22-18(26)13-8-9-16(24)21-13/h12-15H,1-11H2,(H2,20,25)(H,21,24)(H,22,26)/t13-,14-,15-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	6.50E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Washington University Curated by ChEMBL					Assay Description Ability to bind thyroliberin endocrine receptor (TRH-R) using AtT-20 mouse pituitary tumor cells.				Bioorg Med Chem Lett 8: 3093-6 (1999) Article DOI: 10.1016/S0960-894X(98)00567-8 BindingDB Entry DOI: 10.7270/Q21R6PP1
					More data for this Ligand-Target Pair
Thyrotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50196449 ((2S)-1-{(2S)-3-(1-allyl-1H-4-imidazolyl)-2-[(2S)-6...) Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cn(CC=C)cn1)NC(=O)[C@@H]1CCCC(=O)N1 Show InChI InChI=1S/C20H28N6O4/c1-2-8-25-11-13(22-12-25)10-15(20(30)26-9-4-6-16(26)18(21)28)24-19(29)14-5-3-7-17(27)23-14/h2,11-12,14-16H,1,3-10H2,(H2,21,28)(H,23,27)(H,24,29)/t14-,15-,16-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	7.50E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Pharmaceutical Education and Research Curated by ChEMBL					Assay Description Displacement of [3H]N(1)-Me-His-TRH from TRHR1				Bioorg Med Chem 15: 433-43 (2006) Article DOI: 10.1016/j.bmc.2006.09.045 BindingDB Entry DOI: 10.7270/Q2ZW1KJV
					More data for this Ligand-Target Pair
Thyrotropin-releasing hormone receptor (Rattus norvegicus)	BDBM50156183 (3-carbamoyl-1-{6-(2-carbamoyl-pyrrolidin-1-yl)-6-o...) Show SMILES NC(=O)C1CCCN1C(=O)C(CCCC[n+]1cccc(c1)C(N)=O)NC(=O)C1CCC(=O)N1 Show InChI InChI=1S/C22H30N6O5/c23-19(30)14-5-3-11-27(13-14)10-2-1-6-16(26-21(32)15-8-9-18(29)25-15)22(33)28-12-4-7-17(28)20(24)31/h3,5,11,13,15-17H,1-2,4,6-10,12H2,(H5-,23,24,25,26,29,30,31,32)/p+1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florida Curated by ChEMBL					Assay Description Inhibition of [3H]-[3-Me-His2]-TRH binding to thyrotropin releasing hormone receptor of rat forebrain				J Med Chem 47: 6025-33 (2004) Article DOI: 10.1021/jm020531t BindingDB Entry DOI: 10.7270/Q2W095F0
					More data for this Ligand-Target Pair
Thyrotropin-releasing hormone receptor (Rattus norvegicus)	BDBM50156182 (3-carbamoyl-1-{5-(2-carbamoyl-pyrrolidin-1-yl)-5-o...) Show SMILES NC(=O)C1CCCN1C(=O)C(CCC[n+]1cccc(c1)C(N)=O)NC(=O)C1CCC(=O)N1 Show InChI InChI=1S/C21H28N6O5/c22-18(29)13-4-1-9-26(12-13)10-2-5-15(25-20(31)14-7-8-17(28)24-14)21(32)27-11-3-6-16(27)19(23)30/h1,4,9,12,14-16H,2-3,5-8,10-11H2,(H5-,22,23,24,25,28,29,30,31)/p+1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florida Curated by ChEMBL					Assay Description Inhibition of [3H]-[3-Me-His2]-TRH binding to thyrotropin releasing hormone receptor of rat forebrain				J Med Chem 47: 6025-33 (2004) Article DOI: 10.1021/jm020531t BindingDB Entry DOI: 10.7270/Q2W095F0
					More data for this Ligand-Target Pair
Thyrotropin-releasing hormone receptor (Rattus norvegicus)	BDBM50156181 (3-carbamoyl-1-{3-(2-carbamoyl-pyrrolidin-1-yl)-3-o...) Show SMILES NC(=O)C1CCCN1C(=O)C(C[n+]1cccc(c1)C(N)=O)NC(=O)C1CCC(=O)N1 Show InChI InChI=1S/C19H24N6O5/c20-16(27)11-3-1-7-24(9-11)10-13(23-18(29)12-5-6-15(26)22-12)19(30)25-8-2-4-14(25)17(21)28/h1,3,7,9,12-14H,2,4-6,8,10H2,(H5-,20,21,22,23,26,27,28,29)/p+1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florida Curated by ChEMBL					Assay Description Inhibition of [3H]-[3-Me-His2]-TRH binding to thyrotropin releasing hormone receptor of rat forebrain				J Med Chem 47: 6025-33 (2004) Article DOI: 10.1021/jm020531t BindingDB Entry DOI: 10.7270/Q2W095F0
					More data for this Ligand-Target Pair
Thyrotropin-releasing hormone receptor (Rattus norvegicus)	BDBM85330 (CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...) Show SMILES Cc1nccn1CC1CCc2c(C1=O)c1ccccc1n2C Show InChI InChI=1S/C18H19N3O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2/h3-6,9-10,13H,7-8,11H2,1-2H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Solvay Duphar B.V. Curated by ChEMBL					Assay Description The binding affinity of the compound was measured on TRH receptor using [3H]- MeTRH as radioligand.				J Med Chem 36: 3693-9 (1994) BindingDB Entry DOI: 10.7270/Q2NS0SZH
					More data for this Ligand-Target Pair
Thyrotropin-releasing hormone receptor (Xenopus)	BDBM86215 (Pyr3TRH) Show SMILES NC(=O)C1CCCN1C(=O)C(Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)C1 Show InChI InChI=1S/C17H23N5O4/c18-15(24)14-2-1-5-22(14)17(26)13(7-11-8-19-9-20-11)21-16(25)10-3-4-12(23)6-10/h8-10,13-14H,1-7H2,(H2,18,24)(H,19,20)(H,21,25)/t10-,13?,14?/m1/s1	KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Diabetes and Digestive and Kidney Diseases Curated by PDSP Ki Database									Endocrinology 144: 1842-6 (2003) Article DOI: 10.1210/en.2002-221074 BindingDB Entry DOI: 10.7270/Q2736PGN
					More data for this Ligand-Target Pair
Thyrotropin-releasing hormone receptor (MOUSE)	BDBM86215 (Pyr3TRH) Show SMILES NC(=O)C1CCCN1C(=O)C(Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)C1 Show InChI InChI=1S/C17H23N5O4/c18-15(24)14-2-1-5-22(14)17(26)13(7-11-8-19-9-20-11)21-16(25)10-3-4-12(23)6-10/h8-10,13-14H,1-7H2,(H2,18,24)(H,19,20)(H,21,25)/t10-,13?,14?/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Diabetes and Digestive and Kidney Diseases Curated by PDSP Ki Database									Endocrinology 144: 1842-6 (2003) Article DOI: 10.1210/en.2002-221074 BindingDB Entry DOI: 10.7270/Q2736PGN
					More data for this Ligand-Target Pair
Thyrotropin-releasing hormone receptor (Rattus norvegicus)	BDBM50231569 (Cilansetron | KC-9946) Show SMILES Cc1nccn1C[C@H]1CCc2c(C1=O)c1cccc3CCCn2c13 Show InChI InChI=1S/C20H21N3O/c1-13-21-9-11-22(13)12-15-7-8-17-18(20(15)24)16-6-2-4-14-5-3-10-23(17)19(14)16/h2,4,6,9,11,15H,3,5,7-8,10,12H2,1H3/t15-/m1/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Solvay Duphar B.V. Curated by ChEMBL					Assay Description The binding affinity was measured on TRH receptor using [3H]- MeTRH as radioligand.				J Med Chem 36: 3693-9 (1994) BindingDB Entry DOI: 10.7270/Q2NS0SZH
					More data for this Ligand-Target Pair
Thyrotropin-releasing hormone receptor (Rattus norvegicus)	BDBM50156179 (3-carbamoyl-1-{4-(2-carbamoyl-pyrrolidin-1-yl)-4-o...) Show SMILES NC(=O)C1CCCN1C(=O)C(CC[n+]1cccc(c1)C(N)=O)NC(=O)C1CCC(=O)N1 Show InChI InChI=1S/C20H26N6O5/c21-17(28)12-3-1-8-25(11-12)10-7-14(24-19(30)13-5-6-16(27)23-13)20(31)26-9-2-4-15(26)18(22)29/h1,3,8,11,13-15H,2,4-7,9-10H2,(H5-,21,22,23,24,27,28,29,30)/p+1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florida Curated by ChEMBL					Assay Description Inhibition of [3H]-[3-Me-His2]-TRH binding to thyrotropin releasing hormone receptor of rat forebrain				J Med Chem 47: 6025-33 (2004) Article DOI: 10.1021/jm020531t BindingDB Entry DOI: 10.7270/Q2W095F0
					More data for this Ligand-Target Pair
Thyrotropin-releasing hormone receptor (Rattus norvegicus)	BDBM50173828 (1-[2-[5-oxo-(2S)-tetrahydro-1H-2-pyrrolylcarboxami...) Show SMILES CCCc1ncc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)[nH]1 Show InChI InChI=1S/C19H28N6O4/c1-2-4-15-21-10-11(22-15)9-13(24-18(28)12-6-7-16(26)23-12)19(29)25-8-3-5-14(25)17(20)27/h10,12-14H,2-9H2,1H3,(H2,20,27)(H,21,22)(H,23,26)(H,24,28)/t12-,13-,14-/m0/s1	KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.70E+4	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
National Institute of Pharmaceutical Education and Research Curated by ChEMBL					Assay Description Inhibitory constant against thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells upon incubation at 37 degee C for 1 hr at pH 7.4 us...				J Med Chem 48: 6162-5 (2005) Article DOI: 10.1021/jm0505462 BindingDB Entry DOI: 10.7270/Q2PK0FQG
					More data for this Ligand-Target Pair
Thyrotropin-releasing hormone receptor (Rattus norvegicus)	BDBM50196449 ((2S)-1-{(2S)-3-(1-allyl-1H-4-imidazolyl)-2-[(2S)-6...) Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cn(CC=C)cn1)NC(=O)[C@@H]1CCCC(=O)N1 Show InChI InChI=1S/C20H28N6O4/c1-2-8-25-11-13(22-12-25)10-15(20(30)26-9-4-6-16(26)18(21)28)24-19(29)14-5-3-7-17(27)23-14/h2,11-12,14-16H,1,3-10H2,(H2,21,28)(H,23,27)(H,24,29)/t14-,15-,16-/m0/s1	KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.10E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Pharmaceutical Education and Research Curated by ChEMBL					Assay Description Displacement of [3H]N(1)-Me-His-TRH from TRHR2				Bioorg Med Chem 15: 433-43 (2006) Article DOI: 10.1016/j.bmc.2006.09.045 BindingDB Entry DOI: 10.7270/Q2ZW1KJV
					More data for this Ligand-Target Pair
Thyrotropin-releasing hormone receptor (MOUSE)	BDBM50072397 (7-cyclohexyl-6-(2,6-dioxo-1,7-diazaspiro[4.4]non-7...) Show SMILES NC(=O)[C@@H]1CC[C@@H]2CC(C3CCCCC3)=C(N3CC[C@]4(CCC(=O)N4)C3=O)C(=O)N12 |t:15| Show InChI InChI=1S/C22H30N4O4/c23-19(28)16-7-6-14-12-15(13-4-2-1-3-5-13)18(20(29)26(14)16)25-11-10-22(21(25)30)9-8-17(27)24-22/h13-14,16H,1-12H2,(H2,23,28)(H,24,27)/t14-,16+,22-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.60E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Washington University Curated by ChEMBL					Assay Description Ability to bind thyroliberin endocrine receptor (TRH-R) using AtT-20 mouse pituitary tumor cells.				Bioorg Med Chem Lett 8: 3093-6 (1999) Article DOI: 10.1016/S0960-894X(98)00567-8 BindingDB Entry DOI: 10.7270/Q21R6PP1
					More data for this Ligand-Target Pair
Thyrotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50196458 ((2S)-1-{(2S)-3-(1-benzyl-1H-4-imidazolyl)-2-[(2S)-...) Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cn(Cc2ccccc2)cn1)NC(=O)[C@@H]1CCCC(=O)N1 Show InChI InChI=1S/C24H30N6O4/c25-22(32)20-9-5-11-30(20)24(34)19(28-23(33)18-8-4-10-21(31)27-18)12-17-14-29(15-26-17)13-16-6-2-1-3-7-16/h1-3,6-7,14-15,18-20H,4-5,8-13H2,(H2,25,32)(H,27,31)(H,28,33)/t18-,19-,20-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Pharmaceutical Education and Research Curated by ChEMBL					Assay Description Displacement of [3H]N(1)-Me-His-TRH from TRHR1				Bioorg Med Chem 15: 433-43 (2006) Article DOI: 10.1016/j.bmc.2006.09.045 BindingDB Entry DOI: 10.7270/Q2ZW1KJV
					More data for this Ligand-Target Pair
Thyrotropin-releasing hormone receptor (Rattus norvegicus)	BDBM50196452 ((2S)-1-[(2S)-2-(1S)-3-oxocyclopentylcarboxamido]-3...) Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc([nH]1)C1CCCCC1)NC(=O)[C@H]1CCC(=O)C1 Show InChI InChI=1S/C23H33N5O4/c24-20(30)19-7-4-10-28(19)23(32)18(27-22(31)15-8-9-17(29)11-15)12-16-13-25-21(26-16)14-5-2-1-3-6-14/h13-15,18-19H,1-12H2,(H2,24,30)(H,25,26)(H,27,31)/t15-,18-,19-/m0/s1	KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Pharmaceutical Education and Research Curated by ChEMBL					Assay Description Displacement of [3H]N(1)-Me-His-TRH from TRHR2				Bioorg Med Chem 15: 433-43 (2006) Article DOI: 10.1016/j.bmc.2006.09.045 BindingDB Entry DOI: 10.7270/Q2ZW1KJV
					More data for this Ligand-Target Pair
Thyrotropin-releasing hormone receptor (Rattus norvegicus)	BDBM50173821 (1-[3-[2-(tert-butyl)-1H-4-imidazolyl]-2-[5-oxo-(2S...) Show SMILES CC(C)(C)c1ncc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)[nH]1 Show InChI InChI=1S/C20H30N6O4/c1-20(2,3)19-22-10-11(23-19)9-13(25-17(29)12-6-7-15(27)24-12)18(30)26-8-4-5-14(26)16(21)28/h10,12-14H,4-9H2,1-3H3,(H2,21,28)(H,22,23)(H,24,27)(H,25,29)/t12-,13-,14-/m0/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
National Institute of Pharmaceutical Education and Research Curated by ChEMBL					Assay Description Inhibitory constant against thyrotropin releasing hormone receptor 1 expressed in HEK 293EM cells upon incubation at 37 degee C for 1 hr at pH 7.4 us...				J Med Chem 48: 6162-5 (2005) Article DOI: 10.1021/jm0505462 BindingDB Entry DOI: 10.7270/Q2PK0FQG
					More data for this Ligand-Target Pair
Thyrotropin-releasing hormone receptor (Rattus norvegicus)	BDBM50173822 (1-[3-(2-cyclohexyl-1H-4-imidazolyl)-2-[5-oxo-(2S)-...) Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc([nH]1)C1CCCCC1)NC(=O)[C@@H]1CCC(=O)N1 Show InChI InChI=1S/C22H32N6O4/c23-19(30)17-7-4-10-28(17)22(32)16(27-21(31)15-8-9-18(29)26-15)11-14-12-24-20(25-14)13-5-2-1-3-6-13/h12-13,15-17H,1-11H2,(H2,23,30)(H,24,25)(H,26,29)(H,27,31)/t15-,16-,17-/m0/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
National Institute of Pharmaceutical Education and Research Curated by ChEMBL					Assay Description Inhibitory constant against thyrotropin releasing hormone receptor 1 expressed in HEK 293EM cells upon incubation at 37 degee C for 1 hr at pH 7.4 us...				J Med Chem 48: 6162-5 (2005) Article DOI: 10.1021/jm0505462 BindingDB Entry DOI: 10.7270/Q2PK0FQG
					More data for this Ligand-Target Pair
Thyrotropin-releasing hormone receptor (Rattus norvegicus)	BDBM50173825 (1-[3-(2-isopropyl-1H-4-imidazolyl)-2-[5-oxo-(2S)-t...) Show SMILES CC(C)c1ncc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)[nH]1 Show InChI InChI=1S/C19H28N6O4/c1-10(2)17-21-9-11(22-17)8-13(24-18(28)12-5-6-15(26)23-12)19(29)25-7-3-4-14(25)16(20)27/h9-10,12-14H,3-8H2,1-2H3,(H2,20,27)(H,21,22)(H,23,26)(H,24,28)/t12-,13-,14-/m0/s1	KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
National Institute of Pharmaceutical Education and Research Curated by ChEMBL					Assay Description Inhibitory constant against thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells upon incubation at 37 degee C for 1 hr at pH 7.4 us...				J Med Chem 48: 6162-5 (2005) Article DOI: 10.1021/jm0505462 BindingDB Entry DOI: 10.7270/Q2PK0FQG
					More data for this Ligand-Target Pair
Thyrotropin-releasing hormone receptor (Rattus norvegicus)	BDBM50173822 (1-[3-(2-cyclohexyl-1H-4-imidazolyl)-2-[5-oxo-(2S)-...) Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc([nH]1)C1CCCCC1)NC(=O)[C@@H]1CCC(=O)N1 Show InChI InChI=1S/C22H32N6O4/c23-19(30)17-7-4-10-28(17)22(32)16(27-21(31)15-8-9-18(29)26-15)11-14-12-24-20(25-14)13-5-2-1-3-6-13/h12-13,15-17H,1-11H2,(H2,23,30)(H,24,25)(H,26,29)(H,27,31)/t15-,16-,17-/m0/s1	KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
National Institute of Pharmaceutical Education and Research Curated by ChEMBL					Assay Description Inhibitory constant against thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells upon incubation at 37 degee C for 1 hr at pH 7.4 us...				J Med Chem 48: 6162-5 (2005) Article DOI: 10.1021/jm0505462 BindingDB Entry DOI: 10.7270/Q2PK0FQG
					More data for this Ligand-Target Pair
Thyrotropin-releasing hormone receptor (Rattus norvegicus)	BDBM50173824 (1-[3-{2-[1-(1-adamantyl)ethyl]-1H-4-imidazolyl}-2-...) Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc([nH]1)C12CC3CC(CC(C3)C1)C2)NC(=O)[C@@H]1CCC(=O)N1 |TLB:24:19:26:25.23.22,24:23:26:18.19.20,THB:22:21:18:25.23.24,22:23:18:26.21.20| Show InChI InChI=1S/C26H36N6O4/c27-22(34)20-2-1-5-32(20)24(36)19(31-23(35)18-3-4-21(33)30-18)9-17-13-28-25(29-17)26-10-14-6-15(11-26)8-16(7-14)12-26/h13-16,18-20H,1-12H2,(H2,27,34)(H,28,29)(H,30,33)(H,31,35)/t14?,15?,16?,18-,19-,20-,26?/m0/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
National Institute of Pharmaceutical Education and Research Curated by ChEMBL					Assay Description Inhibitory constant against thyrotropin releasing hormone receptor 1 expressed in HEK 293EM cells upon incubation at 37 degee C for 1 hr at pH 7.4 us...				J Med Chem 48: 6162-5 (2005) Article DOI: 10.1021/jm0505462 BindingDB Entry DOI: 10.7270/Q2PK0FQG
					More data for this Ligand-Target Pair
Thyrotropin-releasing hormone receptor (Rattus norvegicus)	BDBM50173821 (1-[3-[2-(tert-butyl)-1H-4-imidazolyl]-2-[5-oxo-(2S...) Show SMILES CC(C)(C)c1ncc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)[nH]1 Show InChI InChI=1S/C20H30N6O4/c1-20(2,3)19-22-10-11(23-19)9-13(25-17(29)12-6-7-15(27)24-12)18(30)26-8-4-5-14(26)16(21)28/h10,12-14H,4-9H2,1-3H3,(H2,21,28)(H,22,23)(H,24,27)(H,25,29)/t12-,13-,14-/m0/s1	KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
National Institute of Pharmaceutical Education and Research Curated by ChEMBL					Assay Description Inhibitory constant against thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells upon incubation at 37 degee C for 1 hr at pH 7.4 us...				J Med Chem 48: 6162-5 (2005) Article DOI: 10.1021/jm0505462 BindingDB Entry DOI: 10.7270/Q2PK0FQG
					More data for this Ligand-Target Pair
Thyrotropin-releasing hormone receptor (Rattus norvegicus)	BDBM50173824 (1-[3-{2-[1-(1-adamantyl)ethyl]-1H-4-imidazolyl}-2-...) Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc([nH]1)C12CC3CC(CC(C3)C1)C2)NC(=O)[C@@H]1CCC(=O)N1 |TLB:24:19:26:25.23.22,24:23:26:18.19.20,THB:22:21:18:25.23.24,22:23:18:26.21.20| Show InChI InChI=1S/C26H36N6O4/c27-22(34)20-2-1-5-32(20)24(36)19(31-23(35)18-3-4-21(33)30-18)9-17-13-28-25(29-17)26-10-14-6-15(11-26)8-16(7-14)12-26/h13-16,18-20H,1-12H2,(H2,27,34)(H,28,29)(H,30,33)(H,31,35)/t14?,15?,16?,18-,19-,20-,26?/m0/s1	KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
National Institute of Pharmaceutical Education and Research Curated by ChEMBL					Assay Description Inhibitory constant against thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells upon incubation at 37 degee C for 1 hr at pH 7.4 us...				J Med Chem 48: 6162-5 (2005) Article DOI: 10.1021/jm0505462 BindingDB Entry DOI: 10.7270/Q2PK0FQG
					More data for this Ligand-Target Pair
Thyrotropin-releasing hormone receptor (Rattus norvegicus)	BDBM50173827 (1-[3-(2-cyclopropyl-1H-4-imidazolyl)-2-[5-oxo-(2S)...) Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc([nH]1)C1CC1)NC(=O)[C@@H]1CCC(=O)N1 Show InChI InChI=1S/C19H26N6O4/c20-16(27)14-2-1-7-25(14)19(29)13(24-18(28)12-5-6-15(26)23-12)8-11-9-21-17(22-11)10-3-4-10/h9-10,12-14H,1-8H2,(H2,20,27)(H,21,22)(H,23,26)(H,24,28)/t12-,13-,14-/m0/s1	KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
National Institute of Pharmaceutical Education and Research Curated by ChEMBL					Assay Description Inhibitory constant against thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells upon incubation at 37 degee C for 1 hr at pH 7.4 us...				J Med Chem 48: 6162-5 (2005) Article DOI: 10.1021/jm0505462 BindingDB Entry DOI: 10.7270/Q2PK0FQG
					More data for this Ligand-Target Pair
Thyrotropin-releasing hormone receptor (Rattus norvegicus)	BDBM50173825 (1-[3-(2-isopropyl-1H-4-imidazolyl)-2-[5-oxo-(2S)-t...) Show SMILES CC(C)c1ncc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)[nH]1 Show InChI InChI=1S/C19H28N6O4/c1-10(2)17-21-9-11(22-17)8-13(24-18(28)12-5-6-15(26)23-12)19(29)25-7-3-4-14(25)16(20)27/h9-10,12-14H,3-8H2,1-2H3,(H2,20,27)(H,21,22)(H,23,26)(H,24,28)/t12-,13-,14-/m0/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
National Institute of Pharmaceutical Education and Research Curated by ChEMBL					Assay Description Inhibitory constant against thyrotropin releasing hormone receptor 1 expressed in HEK 293EM cells upon incubation at 37 degee C for 1 hr at pH 7.4 us...				J Med Chem 48: 6162-5 (2005) Article DOI: 10.1021/jm0505462 BindingDB Entry DOI: 10.7270/Q2PK0FQG
					More data for this Ligand-Target Pair
Thyrotropin-releasing hormone receptor (Rattus norvegicus)	BDBM50173827 (1-[3-(2-cyclopropyl-1H-4-imidazolyl)-2-[5-oxo-(2S)...) Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc([nH]1)C1CC1)NC(=O)[C@@H]1CCC(=O)N1 Show InChI InChI=1S/C19H26N6O4/c20-16(27)14-2-1-7-25(14)19(29)13(24-18(28)12-5-6-15(26)23-12)8-11-9-21-17(22-11)10-3-4-10/h9-10,12-14H,1-8H2,(H2,20,27)(H,21,22)(H,23,26)(H,24,28)/t12-,13-,14-/m0/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
National Institute of Pharmaceutical Education and Research Curated by ChEMBL					Assay Description Inhibitory constant against thyrotropin releasing hormone receptor 1 expressed in HEK 293EM cells upon incubation at 37 degee C for 1 hr at pH 7.4 us...				J Med Chem 48: 6162-5 (2005) Article DOI: 10.1021/jm0505462 BindingDB Entry DOI: 10.7270/Q2PK0FQG
					More data for this Ligand-Target Pair

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