Compile Data Set for Download or QSAR

Found 47 hits Enz. Inhib. hit(s) with all data for entry = 6313   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM122451 (US8729074, 8) Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2ccc(cn12)-c1cccnc1 Show InChI InChI=1S/C23H15ClFN5O2S/c24-23-20(29-33(31,32)19-6-4-18(25)5-7-19)10-17(12-28-23)21-13-27-22-8-3-16(14-30(21)22)15-2-1-9-26-11-15/h1-14,29H	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,...				US Patent US8729074 (2014) BindingDB Entry DOI: 10.7270/Q2RJ4H4G
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM122459 (US8729074, 19) Show SMILES CN(C)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2ccc(cn12)-c1ccnc(c1)C(F)(F)F Show InChI InChI=1S/C20H16ClF3N6O2S/c1-29(2)33(31,32)28-15-7-14(9-27-19(15)21)16-10-26-18-4-3-13(11-30(16)18)12-5-6-25-17(8-12)20(22,23)24/h3-11,28H,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,...				US Patent US8729074 (2014) BindingDB Entry DOI: 10.7270/Q2RJ4H4G
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM122468 (US8729074, 18) Show SMILES CN(C)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2ccc(cn12)-c1ccncc1 Show InChI InChI=1S/C19H17ClN6O2S/c1-25(2)29(27,28)24-16-9-15(10-23-19(16)20)17-11-22-18-4-3-14(12-26(17)18)13-5-7-21-8-6-13/h3-12,24H,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,...				US Patent US8729074 (2014) BindingDB Entry DOI: 10.7270/Q2RJ4H4G
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM122450 (US8729074, 7) Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2ccc(cn12)-c1ccncc1 Show InChI InChI=1S/C23H15ClFN5O2S/c24-23-20(29-33(31,32)19-4-2-18(25)3-5-19)11-17(12-28-23)21-13-27-22-6-1-16(14-30(21)22)15-7-9-26-10-8-15/h1-14,29H	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	2	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,...				US Patent US8729074 (2014) BindingDB Entry DOI: 10.7270/Q2RJ4H4G
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM122452 (US8729074, 9) Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2ccc(cn12)N1CCOCC1 Show InChI InChI=1S/C22H19ClFN5O3S/c23-22-19(27-33(30,31)18-4-1-16(24)2-5-18)11-15(12-26-22)20-13-25-21-6-3-17(14-29(20)21)28-7-9-32-10-8-28/h1-6,11-14,27H,7-10H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	4	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,...				US Patent US8729074 (2014) BindingDB Entry DOI: 10.7270/Q2RJ4H4G
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM122469 (US8729074, 23) Show SMILES CN(C)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2cc(C)c(cn12)-c1ccncc1 Show InChI InChI=1S/C20H19ClN6O2S/c1-13-8-19-23-11-18(27(19)12-16(13)14-4-6-22-7-5-14)15-9-17(20(21)24-10-15)25-30(28,29)26(2)3/h4-12,25H,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,...				US Patent US8729074 (2014) BindingDB Entry DOI: 10.7270/Q2RJ4H4G
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM122460 (US8729074, 20) Show SMILES CS(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2cc(ccn12)-c1cccnc1 Show InChI InChI=1S/C18H14ClN5O2S/c1-27(25,26)23-15-7-14(10-22-18(15)19)16-11-21-17-8-12(4-6-24(16)17)13-3-2-5-20-9-13/h2-11,23H,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,...				US Patent US8729074 (2014) BindingDB Entry DOI: 10.7270/Q2RJ4H4G
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM122449 (US8729074, 6) Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2ccc(Br)cn12 Show InChI InChI=1S/C18H11BrClFN4O2S/c19-12-1-6-17-22-9-16(25(17)10-12)11-7-15(18(20)23-8-11)24-28(26,27)14-4-2-13(21)3-5-14/h1-10,24H	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	6	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,...				US Patent US8729074 (2014) BindingDB Entry DOI: 10.7270/Q2RJ4H4G
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM122461 (US8729074, 21) Show SMILES CN(C)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2cc(ccn12)-c1ccncc1 Show InChI InChI=1S/C19H17ClN6O2S/c1-25(2)29(27,28)24-16-9-15(11-23-19(16)20)17-12-22-18-10-14(5-8-26(17)18)13-3-6-21-7-4-13/h3-12,24H,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,...				US Patent US8729074 (2014) BindingDB Entry DOI: 10.7270/Q2RJ4H4G
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM122465 (US8729074, 4) Show SMILES Cc1ccn2c(cnc2c1)-c1cnc(Cl)c(NS(=O)(=O)c2ccc(F)cc2)c1 Show InChI InChI=1S/C19H14ClFN4O2S/c1-12-6-7-25-17(11-22-18(25)8-12)13-9-16(19(20)23-10-13)24-28(26,27)15-4-2-14(21)3-5-15/h2-11,24H,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	19	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,...				US Patent US8729074 (2014) BindingDB Entry DOI: 10.7270/Q2RJ4H4G
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM122448 (US8729074, 5) Show SMILES Cc1nc2ccc(Br)cn2c1-c1cnc(Cl)c(NS(=O)(=O)c2ccc(F)cc2)c1 Show InChI InChI=1S/C19H13BrClFN4O2S/c1-11-18(26-10-13(20)2-7-17(26)24-11)12-8-16(19(21)23-9-12)25-29(27,28)15-5-3-14(22)4-6-15/h2-10,25H,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	20	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,...				US Patent US8729074 (2014) BindingDB Entry DOI: 10.7270/Q2RJ4H4G
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM122462 (US8729074, 22) Show SMILES CN(C)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2cc(ccn12)-c1cccnc1 Show InChI InChI=1S/C19H17ClN6O2S/c1-25(2)29(27,28)24-16-8-15(11-23-19(16)20)17-12-22-18-9-13(5-7-26(17)18)14-4-3-6-21-10-14/h3-12,24H,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	21	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,...				US Patent US8729074 (2014) BindingDB Entry DOI: 10.7270/Q2RJ4H4G
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM122463 (US8729074, 25) Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2ccc(Cl)nn12 Show InChI InChI=1S/C17H10Cl2FN5O2S/c18-15-5-6-16-21-9-14(25(16)23-15)10-7-13(17(19)22-8-10)24-28(26,27)12-3-1-11(20)2-4-12/h1-9,24H	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	22	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,...				US Patent US8729074 (2014) BindingDB Entry DOI: 10.7270/Q2RJ4H4G
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM122464 (US8729074, 3) Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2ccccn12 Show InChI InChI=1S/C18H12ClFN4O2S/c19-18-15(23-27(25,26)14-6-4-13(20)5-7-14)9-12(10-22-18)16-11-21-17-3-1-2-8-24(16)17/h1-11,23H	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	28	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,...				US Patent US8729074 (2014) BindingDB Entry DOI: 10.7270/Q2RJ4H4G
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM122446 (US8729074, 1) Show SMILES Cc1nc2ccccn2c1-c1cnc(Cl)c(NS(=O)(=O)c2ccc(F)cc2)c1 Show InChI InChI=1S/C19H14ClFN4O2S/c1-12-18(25-9-3-2-4-17(25)23-12)13-10-16(19(20)22-11-13)24-28(26,27)15-7-5-14(21)6-8-15/h2-11,24H,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	126	n/a	76	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,...				US Patent US8729074 (2014) BindingDB Entry DOI: 10.7270/Q2RJ4H4G
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM122456 (US8729074, 14) Show SMILES COc1cc(cnc1OC)-c1cnc2ccc(cn12)N1[C@H](Cc2ccccc2)COC1=O |r| Show InChI InChI=1S/C24H22N4O4/c1-30-21-11-17(12-26-23(21)31-2)20-13-25-22-9-8-18(14-27(20)22)28-19(15-32-24(28)29)10-16-6-4-3-5-7-16/h3-9,11-14,19H,10,15H2,1-2H3/t19-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	268	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,...				US Patent US8729074 (2014) BindingDB Entry DOI: 10.7270/Q2RJ4H4G
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM122457 (US8729074, 15) Show SMILES COc1cc(cnc1OC)-c1cnc2ccc(cn12)N1[C@@H](Cc2ccccc2)COC1=O |r| Show InChI InChI=1S/C24H22N4O4/c1-30-21-11-17(12-26-23(21)31-2)20-13-25-22-9-8-18(14-27(20)22)28-19(15-32-24(28)29)10-16-6-4-3-5-7-16/h3-9,11-14,19H,10,15H2,1-2H3/t19-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	286	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,...				US Patent US8729074 (2014) BindingDB Entry DOI: 10.7270/Q2RJ4H4G
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM122470 (US8729074, 24) Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2ncccn12 Show InChI InChI=1S/C17H11ClFN5O2S/c18-16-14(23-27(25,26)13-4-2-12(19)3-5-13)8-11(9-21-16)15-10-22-17-20-6-1-7-24(15)17/h1-10,23H	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	378	n/a	781	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,...				US Patent US8729074 (2014) BindingDB Entry DOI: 10.7270/Q2RJ4H4G
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM122467 (US8729074, 17) Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2ccn(Cc3ccccc3)c(=O)n12 Show InChI InChI=1S/C24H17ClFN5O3S/c25-23-20(29-35(33,34)19-8-6-18(26)7-9-19)12-17(13-28-23)21-14-27-22-10-11-30(24(32)31(21)22)15-16-4-2-1-3-5-16/h1-14,29H,15H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	465	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,...				US Patent US8729074 (2014) BindingDB Entry DOI: 10.7270/Q2RJ4H4G
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM122454 (US8729074, 12) Show SMILES COc1cc(cnc1OC)-c1cnc2ccc(cn12)-c1ccncc1 Show InChI InChI=1S/C19H16N4O2/c1-24-17-9-15(10-22-19(17)25-2)16-11-21-18-4-3-14(12-23(16)18)13-5-7-20-8-6-13/h3-12H,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	626	n/a	861	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,...				US Patent US8729074 (2014) BindingDB Entry DOI: 10.7270/Q2RJ4H4G
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM122453 (US8729074, 11) Show SMILES COc1cc(cnc1OC)-c1cnc2ccc(Br)cn12 Show InChI InChI=1S/C14H12BrN3O2/c1-19-12-5-9(6-17-14(12)20-2)11-7-16-13-4-3-10(15)8-18(11)13/h3-8H,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	779	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,...				US Patent US8729074 (2014) BindingDB Entry DOI: 10.7270/Q2RJ4H4G
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM122458 (US8729074, 16) Show SMILES COc1cc(cnc1OC)-c1cnc2ccc(cn12)N1CCOCC1 Show InChI InChI=1S/C18H20N4O3/c1-23-16-9-13(10-20-18(16)24-2)15-11-19-17-4-3-14(12-22(15)17)21-5-7-25-8-6-21/h3-4,9-12H,5-8H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.08E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,...				US Patent US8729074 (2014) BindingDB Entry DOI: 10.7270/Q2RJ4H4G
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM122447 (US8729074, 2) Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cncc(c1)-c1cnc2ccccn12 Show InChI InChI=1S/C18H13FN4O2S/c19-14-4-6-16(7-5-14)26(24,25)22-15-9-13(10-20-11-15)17-12-21-18-3-1-2-8-23(17)18/h1-12,22H	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.29E+3	n/a	931	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,...				US Patent US8729074 (2014) BindingDB Entry DOI: 10.7270/Q2RJ4H4G
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM122455 (US8729074, 13) Show SMILES COc1cc(cnc1OC)-c1cnc2ccc(cn12)N1CCOC1=O Show InChI InChI=1S/C17H16N4O4/c1-23-14-7-11(8-19-16(14)24-2)13-9-18-15-4-3-12(10-21(13)15)20-5-6-25-17(20)22/h3-4,7-10H,5-6H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	>1.50E+3	n/a	4.67E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,...				US Patent US8729074 (2014) BindingDB Entry DOI: 10.7270/Q2RJ4H4G
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM122466 (US8729074, 10) Show SMILES COc1cc(cnc1OC)-c1cnc2ccccn12 Show InChI InChI=1S/C14H13N3O2/c1-18-12-7-10(8-16-14(12)19-2)11-9-15-13-5-3-4-6-17(11)13/h3-9H,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	>1.50E+3	n/a	1.57E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,...				US Patent US8729074 (2014) BindingDB Entry DOI: 10.7270/Q2RJ4H4G
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM122459 (US8729074, 19) Show SMILES CN(C)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2ccc(cn12)-c1ccnc(c1)C(F)(F)F Show InChI InChI=1S/C20H16ClF3N6O2S/c1-29(2)33(31,32)28-15-7-14(9-27-19(15)21)16-10-26-18-4-3-13(11-30(16)18)12-5-6-25-17(8-12)20(22,23)24/h3-11,28H,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vit...				US Patent US8729074 (2014) BindingDB Entry DOI: 10.7270/Q2RJ4H4G
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM122468 (US8729074, 18) Show SMILES CN(C)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2ccc(cn12)-c1ccncc1 Show InChI InChI=1S/C19H17ClN6O2S/c1-25(2)29(27,28)24-16-9-15(10-23-19(16)20)17-11-22-18-4-3-14(12-26(17)18)13-5-7-21-8-6-13/h3-12,24H,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vit...				US Patent US8729074 (2014) BindingDB Entry DOI: 10.7270/Q2RJ4H4G
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM122469 (US8729074, 23) Show SMILES CN(C)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2cc(C)c(cn12)-c1ccncc1 Show InChI InChI=1S/C20H19ClN6O2S/c1-13-8-19-23-11-18(27(19)12-16(13)14-4-6-22-7-5-14)15-9-17(20(21)24-10-15)25-30(28,29)26(2)3/h4-12,25H,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vit...				US Patent US8729074 (2014) BindingDB Entry DOI: 10.7270/Q2RJ4H4G
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM122451 (US8729074, 8) Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2ccc(cn12)-c1cccnc1 Show InChI InChI=1S/C23H15ClFN5O2S/c24-23-20(29-33(31,32)19-6-4-18(25)5-7-19)10-17(12-28-23)21-13-27-22-8-3-16(14-30(21)22)15-2-1-9-26-11-15/h1-14,29H	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vit...				US Patent US8729074 (2014) BindingDB Entry DOI: 10.7270/Q2RJ4H4G
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM122460 (US8729074, 20) Show SMILES CS(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2cc(ccn12)-c1cccnc1 Show InChI InChI=1S/C18H14ClN5O2S/c1-27(25,26)23-15-7-14(10-22-18(15)19)16-11-21-17-8-12(4-6-24(16)17)13-3-2-5-20-9-13/h2-11,23H,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vit...				US Patent US8729074 (2014) BindingDB Entry DOI: 10.7270/Q2RJ4H4G
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM122450 (US8729074, 7) Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2ccc(cn12)-c1ccncc1 Show InChI InChI=1S/C23H15ClFN5O2S/c24-23-20(29-33(31,32)19-4-2-18(25)3-5-19)11-17(12-28-23)21-13-27-22-6-1-16(14-30(21)22)15-7-9-26-10-8-15/h1-14,29H	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vit...				US Patent US8729074 (2014) BindingDB Entry DOI: 10.7270/Q2RJ4H4G
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM122449 (US8729074, 6) Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2ccc(Br)cn12 Show InChI InChI=1S/C18H11BrClFN4O2S/c19-12-1-6-17-22-9-16(25(17)10-12)11-7-15(18(20)23-8-11)24-28(26,27)14-4-2-13(21)3-5-14/h1-10,24H	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vit...				US Patent US8729074 (2014) BindingDB Entry DOI: 10.7270/Q2RJ4H4G
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM122463 (US8729074, 25) Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2ccc(Cl)nn12 Show InChI InChI=1S/C17H10Cl2FN5O2S/c18-15-5-6-16-21-9-14(25(16)23-15)10-7-13(17(19)22-8-10)24-28(26,27)12-3-1-11(20)2-4-12/h1-9,24H	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	102	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vit...				US Patent US8729074 (2014) BindingDB Entry DOI: 10.7270/Q2RJ4H4G
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM122464 (US8729074, 3) Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2ccccn12 Show InChI InChI=1S/C18H12ClFN4O2S/c19-18-15(23-27(25,26)14-6-4-13(20)5-7-14)9-12(10-22-18)16-11-21-17-3-1-2-8-24(16)17/h1-11,23H	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	155	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vit...				US Patent US8729074 (2014) BindingDB Entry DOI: 10.7270/Q2RJ4H4G
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM122462 (US8729074, 22) Show SMILES CN(C)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2cc(ccn12)-c1cccnc1 Show InChI InChI=1S/C19H17ClN6O2S/c1-25(2)29(27,28)24-16-8-15(11-23-19(16)20)17-12-22-18-9-13(5-7-26(17)18)14-4-3-6-21-10-14/h3-12,24H,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	157	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vit...				US Patent US8729074 (2014) BindingDB Entry DOI: 10.7270/Q2RJ4H4G
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM122467 (US8729074, 17) Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2ccn(Cc3ccccc3)c(=O)n12 Show InChI InChI=1S/C24H17ClFN5O3S/c25-23-20(29-35(33,34)19-8-6-18(26)7-9-19)12-17(13-28-23)21-14-27-22-10-11-30(24(32)31(21)22)15-16-4-2-1-3-5-16/h1-14,29H,15H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vit...				US Patent US8729074 (2014) BindingDB Entry DOI: 10.7270/Q2RJ4H4G
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM122461 (US8729074, 21) Show SMILES CN(C)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2cc(ccn12)-c1ccncc1 Show InChI InChI=1S/C19H17ClN6O2S/c1-25(2)29(27,28)24-16-9-15(11-23-19(16)20)17-12-22-18-10-14(5-8-26(17)18)13-3-6-21-7-4-13/h3-12,24H,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	258	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vit...				US Patent US8729074 (2014) BindingDB Entry DOI: 10.7270/Q2RJ4H4G
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM122452 (US8729074, 9) Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2ccc(cn12)N1CCOCC1 Show InChI InChI=1S/C22H19ClFN5O3S/c23-22-19(27-33(30,31)18-4-1-16(24)2-5-18)11-15(12-26-22)20-13-25-21-6-3-17(14-29(20)21)28-7-9-32-10-8-28/h1-6,11-14,27H,7-10H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	364	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vit...				US Patent US8729074 (2014) BindingDB Entry DOI: 10.7270/Q2RJ4H4G
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM122448 (US8729074, 5) Show SMILES Cc1nc2ccc(Br)cn2c1-c1cnc(Cl)c(NS(=O)(=O)c2ccc(F)cc2)c1 Show InChI InChI=1S/C19H13BrClFN4O2S/c1-11-18(26-10-13(20)2-7-17(26)24-11)12-8-16(19(21)23-9-12)25-29(27,28)15-5-3-14(22)4-6-15/h2-10,25H,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	848	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vit...				US Patent US8729074 (2014) BindingDB Entry DOI: 10.7270/Q2RJ4H4G
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM122457 (US8729074, 15) Show SMILES COc1cc(cnc1OC)-c1cnc2ccc(cn12)N1[C@@H](Cc2ccccc2)COC1=O |r| Show InChI InChI=1S/C24H22N4O4/c1-30-21-11-17(12-26-23(21)31-2)20-13-25-22-9-8-18(14-27(20)22)28-19(15-32-24(28)29)10-16-6-4-3-5-7-16/h3-9,11-14,19H,10,15H2,1-2H3/t19-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.04E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vit...				US Patent US8729074 (2014) BindingDB Entry DOI: 10.7270/Q2RJ4H4G
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM122453 (US8729074, 11) Show SMILES COc1cc(cnc1OC)-c1cnc2ccc(Br)cn12 Show InChI InChI=1S/C14H12BrN3O2/c1-19-12-5-9(6-17-14(12)20-2)11-7-16-13-4-3-10(15)8-18(11)13/h3-8H,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.17E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vit...				US Patent US8729074 (2014) BindingDB Entry DOI: 10.7270/Q2RJ4H4G
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM122454 (US8729074, 12) Show SMILES COc1cc(cnc1OC)-c1cnc2ccc(cn12)-c1ccncc1 Show InChI InChI=1S/C19H16N4O2/c1-24-17-9-15(10-22-19(17)25-2)16-11-21-18-4-3-14(12-23(16)18)13-5-7-20-8-6-13/h3-12H,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.75E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vit...				US Patent US8729074 (2014) BindingDB Entry DOI: 10.7270/Q2RJ4H4G
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM122458 (US8729074, 16) Show SMILES COc1cc(cnc1OC)-c1cnc2ccc(cn12)N1CCOCC1 Show InChI InChI=1S/C18H20N4O3/c1-23-16-9-13(10-20-18(16)24-2)15-11-19-17-4-3-14(12-22(15)17)21-5-7-25-8-6-21/h3-4,9-12H,5-8H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.52E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vit...				US Patent US8729074 (2014) BindingDB Entry DOI: 10.7270/Q2RJ4H4G
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM122456 (US8729074, 14) Show SMILES COc1cc(cnc1OC)-c1cnc2ccc(cn12)N1[C@H](Cc2ccccc2)COC1=O |r| Show InChI InChI=1S/C24H22N4O4/c1-30-21-11-17(12-26-23(21)31-2)20-13-25-22-9-8-18(14-27(20)22)28-19(15-32-24(28)29)10-16-6-4-3-5-7-16/h3-9,11-14,19H,10,15H2,1-2H3/t19-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vit...				US Patent US8729074 (2014) BindingDB Entry DOI: 10.7270/Q2RJ4H4G
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM122455 (US8729074, 13) Show SMILES COc1cc(cnc1OC)-c1cnc2ccc(cn12)N1CCOC1=O Show InChI InChI=1S/C17H16N4O4/c1-23-14-7-11(8-19-16(14)24-2)13-9-18-15-4-3-12(10-21(13)15)20-5-6-25-17(20)22/h3-4,7-10H,5-6H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9.66E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vit...				US Patent US8729074 (2014) BindingDB Entry DOI: 10.7270/Q2RJ4H4G
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM122466 (US8729074, 10) Show SMILES COc1cc(cnc1OC)-c1cnc2ccccn12 Show InChI InChI=1S/C14H13N3O2/c1-18-12-7-10(8-16-14(12)19-2)11-9-15-13-5-3-4-6-17(11)13/h3-9H,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vit...				US Patent US8729074 (2014) BindingDB Entry DOI: 10.7270/Q2RJ4H4G
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM122470 (US8729074, 24) Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2ncccn12 Show InChI InChI=1S/C17H11ClFN5O2S/c18-16-14(23-27(25,26)13-4-2-12(19)3-5-13)8-11(9-21-16)15-10-22-17-20-6-1-7-24(15)17/h1-10,23H	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vit...				US Patent US8729074 (2014) BindingDB Entry DOI: 10.7270/Q2RJ4H4G
					More data for this Ligand-Target Pair