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PubMed code 18318469

Compile data set for download or QSAR
Found 75 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21599
PNG
(2-{5-chloro-1'-[(3-methyl-5-phenyl-1,2-oxazol-4-yl...)
Show SMILES Cc1noc(c1CN1CC2(CC1=O)C(=O)N(CC(O)=O)c1ccc(Cl)cc21)-c1ccccc1
Show InChI InChI=1S/C24H20ClN3O5/c1-14-17(22(33-26-14)15-5-3-2-4-6-15)11-27-13-24(10-20(27)29)18-9-16(25)7-8-19(18)28(23(24)32)12-21(30)31/h2-9H,10-13H2,1H3,(H,30,31)
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 3.80n/an/an/a 19n/an/an/an/a



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Mus musculus (mouse))		BDBM21610
PNG
(2-[(3R)-5-chloro-1'-[(5-chloro-2-fluorophenyl)meth...)
Show SMILES OC(=O)CN1C(=O)[C@@]2(CC(=O)N(Cc3cc(Cl)ccc3F)C2=O)c2cc(Cl)ccc12 |r|
Show InChI InChI=1S/C20H13Cl2FN2O5/c21-11-1-3-14(23)10(5-11)8-25-16(26)7-20(19(25)30)13-6-12(22)2-4-15(13)24(18(20)29)9-17(27)28/h1-6H,7-9H2,(H,27,28)/t20-/m1/s1
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 5n/an/an/an/an/an/an/an/a



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21595
PNG
(2-{5-chloro-1'-[(3-methyl-5-phenyl-1,2-oxazol-4-yl...)
Show SMILES Cc1noc(c1CN1C(=O)CC2(C1=O)C(=O)N(CC(O)=O)c1ccc(Cl)cc21)-c1ccccc1
Show InChI InChI=1S/C24H18ClN3O6/c1-13-16(21(34-26-13)14-5-3-2-4-6-14)11-28-19(29)10-24(23(28)33)17-9-15(25)7-8-18(17)27(22(24)32)12-20(30)31/h2-9H,10-12H2,1H3,(H,30,31)
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 5.30n/an/an/a 23n/an/an/an/a



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21610
PNG
(2-[(3R)-5-chloro-1'-[(5-chloro-2-fluorophenyl)meth...)
Show SMILES OC(=O)CN1C(=O)[C@@]2(CC(=O)N(Cc3cc(Cl)ccc3F)C2=O)c2cc(Cl)ccc12 |r|
Show InChI InChI=1S/C20H13Cl2FN2O5/c21-11-1-3-14(23)10(5-11)8-25-16(26)7-20(19(25)30)13-6-12(22)2-4-15(13)24(18(20)29)9-17(27)28/h1-6H,7-9H2,(H,27,28)/t20-/m1/s1
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 5.30n/an/an/a 66n/an/an/an/a



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21594
PNG
(2-{5-chloro-1'-[(5-methyl-3-phenyl-1,2-oxazol-4-yl...)
Show SMILES Cc1onc(c1CN1C(=O)CC2(C1=O)C(=O)N(CC(O)=O)c1ccc(Cl)cc21)-c1ccccc1
Show InChI InChI=1S/C24H18ClN3O6/c1-13-16(21(26-34-13)14-5-3-2-4-6-14)11-28-19(29)10-24(23(28)33)17-9-15(25)7-8-18(17)27(22(24)32)12-20(30)31/h2-9H,10-12H2,1H3,(H,30,31)
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 7.60n/an/an/a 21n/an/an/an/a



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21579
PNG
(2-{5-chloro-1'-[(5-chloro-2-fluorophenyl)methyl]-1...)
Show SMILES OC(=O)CN1C(=O)C2(CC(=O)N(Cc3cc(Cl)ccc3F)C2=O)c2cc(Cl)ccc12
Show InChI InChI=1S/C20H13Cl2FN2O5/c21-11-1-3-14(23)10(5-11)8-25-16(26)7-20(19(25)30)13-6-12(22)2-4-15(13)24(18(20)29)9-17(27)28/h1-6H,7-9H2,(H,27,28)
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 10n/an/an/a 48n/an/an/an/a



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21596
PNG
(2-{5-chloro-1'-[(4-methoxy-3,5-dimethylpyridin-2-y...)
Show SMILES COc1c(C)cnc(CN2C(=O)CC3(C2=O)C(=O)N(CC(O)=O)c2ccc(Cl)cc32)c1C
Show InChI InChI=1S/C22H20ClN3O6/c1-11-8-24-15(12(2)19(11)32-3)9-26-17(27)7-22(21(26)31)14-6-13(23)4-5-16(14)25(20(22)30)10-18(28)29/h4-6,8H,7,9-10H2,1-3H3,(H,28,29)
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 12n/an/an/an/an/an/an/an/a



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21611
PNG
(2-[(3S)-5-chloro-1'-[(5-chloro-2-fluorophenyl)meth...)
Show SMILES OC(=O)CN1C(=O)[C@]2(CN(Cc3cc(Cl)ccc3F)C(=O)C2)c2cc(Cl)ccc12 |r|
Show InChI InChI=1S/C20H15Cl2FN2O4/c21-12-1-3-15(23)11(5-12)8-24-10-20(7-17(24)26)14-6-13(22)2-4-16(14)25(19(20)29)9-18(27)28/h1-6H,7-10H2,(H,27,28)/t20-/m1/s1
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 13n/an/an/an/an/an/an/an/a



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21581
PNG
(2-{5-chloro-1'-[(3-chloro-5-fluorophenyl)methyl]-1...)
Show SMILES OC(=O)CN1C(=O)C2(CC(=O)N(Cc3cc(F)cc(Cl)c3)C2=O)c2cc(Cl)ccc12
Show InChI InChI=1S/C20H13Cl2FN2O5/c21-11-1-2-15-14(6-11)20(18(29)24(15)9-17(27)28)7-16(26)25(19(20)30)8-10-3-12(22)5-13(23)4-10/h1-6H,7-9H2,(H,27,28)
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 20n/an/an/an/an/an/an/an/a



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21575
PNG
(2-{5-chloro-1'-[(2,5-difluorophenyl)methyl]-1,2-di...)
Show SMILES OC(=O)CN1C(=O)C2(CC(=O)N(Cc3cc(F)ccc3F)C2=O)c2cc(Cl)ccc12
Show InChI InChI=1S/C20H13ClF2N2O5/c21-11-1-4-15-13(6-11)20(18(29)24(15)9-17(27)28)7-16(26)25(19(20)30)8-10-5-12(22)2-3-14(10)23/h1-6H,7-9H2,(H,27,28)
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 21n/an/an/an/an/an/an/an/a



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Mus musculus (mouse))		BDBM21603
PNG
(2-[(3R)-5-chloro-1'-[(2-fluorophenyl)methyl]-1,2-d...)
Show SMILES OC(=O)CN1C(=O)[C@@]2(CC(=O)N(Cc3ccccc3F)C2=O)c2cc(Cl)ccc12 |r|
Show InChI InChI=1S/C20H14ClFN2O5/c21-12-5-6-15-13(7-12)20(18(28)23(15)10-17(26)27)8-16(25)24(19(20)29)9-11-3-1-2-4-14(11)22/h1-7H,8-10H2,(H,26,27)/t20-/m1/s1
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 22n/an/an/an/an/an/an/an/a



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21605
PNG
(2-[(3R)-5-chloro-1'-[(3-chlorophenyl)methyl]-1,2-d...)
Show SMILES OC(=O)CN1C(=O)[C@@]2(CC(=O)N(Cc3cccc(Cl)c3)C2=O)c2cc(Cl)ccc12 |r|
Show InChI InChI=1S/C20H14Cl2N2O5/c21-12-3-1-2-11(6-12)9-24-16(25)8-20(19(24)29)14-7-13(22)4-5-15(14)23(18(20)28)10-17(26)27/h1-7H,8-10H2,(H,26,27)/t20-/m1/s1
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 23n/an/an/a 107n/an/an/an/a



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21603
PNG
(2-[(3R)-5-chloro-1'-[(2-fluorophenyl)methyl]-1,2-d...)
Show SMILES OC(=O)CN1C(=O)[C@@]2(CC(=O)N(Cc3ccccc3F)C2=O)c2cc(Cl)ccc12 |r|
Show InChI InChI=1S/C20H14ClFN2O5/c21-12-5-6-15-13(7-12)20(18(28)23(15)10-17(26)27)8-16(25)24(19(20)29)9-11-3-1-2-4-14(11)22/h1-7H,8-10H2,(H,26,27)/t20-/m1/s1
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 23n/an/an/an/an/an/an/an/a



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21585
PNG
(2-(5-chloro-1'-{[2-(3-chlorophenyl)-1,3-thiazol-4-...)
Show SMILES OC(=O)CN1C(=O)C2(CC(=O)N(Cc3csc(n3)-c3cccc(Cl)c3)C2=O)c2cc(Cl)ccc12
Show InChI InChI=1S/C23H15Cl2N3O5S/c24-13-3-1-2-12(6-13)20-26-15(11-34-20)9-28-18(29)8-23(22(28)33)16-7-14(25)4-5-17(16)27(21(23)32)10-19(30)31/h1-7,11H,8-10H2,(H,30,31)
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 24n/an/an/a 48n/an/an/an/a



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21574
PNG
(2-{5-chloro-1'-[(2,3-difluorophenyl)methyl]-1,2-di...)
Show SMILES OC(=O)CN1C(=O)C2(CC(=O)N(Cc3cccc(F)c3F)C2=O)c2cc(Cl)ccc12
Show InChI InChI=1S/C20H13ClF2N2O5/c21-11-4-5-14-12(6-11)20(18(29)24(14)9-16(27)28)7-15(26)25(19(20)30)8-10-2-1-3-13(22)17(10)23/h1-6H,7-9H2,(H,27,28)
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 25n/an/an/a 296n/an/an/an/a



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21598
PNG
(2-{5-chloro-1'-[(5-chloro-2-fluorophenyl)methyl]-1...)
Show SMILES OC(=O)CN1C(=O)C2(CN(Cc3cc(Cl)ccc3F)C(=O)C2)c2cc(Cl)ccc12
Show InChI InChI=1S/C20H15Cl2FN2O4/c21-12-1-3-15(23)11(5-12)8-24-10-20(7-17(24)26)14-6-13(22)2-4-16(14)25(19(20)29)9-18(27)28/h1-6H,7-10H2,(H,27,28)
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 32n/an/an/an/an/an/an/an/a



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Mus musculus (mouse))		BDBM21605
PNG
(2-[(3R)-5-chloro-1'-[(3-chlorophenyl)methyl]-1,2-d...)
Show SMILES OC(=O)CN1C(=O)[C@@]2(CC(=O)N(Cc3cccc(Cl)c3)C2=O)c2cc(Cl)ccc12 |r|
Show InChI InChI=1S/C20H14Cl2N2O5/c21-12-3-1-2-11(6-12)9-24-16(25)8-20(19(24)29)14-7-13(22)4-5-15(14)23(18(20)28)10-17(26)27/h1-7H,8-10H2,(H,26,27)/t20-/m1/s1
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 33n/an/an/an/an/an/an/an/a



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21580
PNG
(2-{5-chloro-1'-[(3,5-dichlorophenyl)methyl]-1,2-di...)
Show SMILES OC(=O)CN1C(=O)C2(CC(=O)N(Cc3cc(Cl)cc(Cl)c3)C2=O)c2cc(Cl)ccc12
Show InChI InChI=1S/C20H13Cl3N2O5/c21-11-1-2-15-14(6-11)20(18(29)24(15)9-17(27)28)7-16(26)25(19(20)30)8-10-3-12(22)5-13(23)4-10/h1-6H,7-9H2,(H,27,28)
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 36n/an/an/a 82n/an/an/an/a



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21566
PNG
(2-{5-chloro-1'-[(2-fluorophenyl)methyl]-1,2-dihydr...)
Show SMILES OC(=O)CN1C(=O)C2(CC(=O)N(Cc3ccccc3F)C2=O)c2cc(Cl)ccc12
Show InChI InChI=1S/C20H14ClFN2O5/c21-12-5-6-15-13(7-12)20(18(28)23(15)10-17(26)27)8-16(25)24(19(20)29)9-11-3-1-2-4-14(11)22/h1-7H,8-10H2,(H,26,27)
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 37 -42.0n/an/a 212n/an/a7.422



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21576
PNG
(2-{5-chloro-1'-[(3,5-difluorophenyl)methyl]-1,2-di...)
Show SMILES OC(=O)CN1C(=O)C2(CC(=O)N(Cc3cc(F)cc(F)c3)C2=O)c2cc(Cl)ccc12
Show InChI InChI=1S/C20H13ClF2N2O5/c21-11-1-2-15-14(5-11)20(18(29)24(15)9-17(27)28)7-16(26)25(19(20)30)8-10-3-12(22)6-13(23)4-10/h1-6H,7-9H2,(H,27,28)
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 37n/an/an/an/an/an/an/an/a



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21584
PNG
(2-{5-chloro-1'-[(2-methyl-1,3-thiazol-4-yl)methyl]...)
Show SMILES Cc1nc(CN2C(=O)CC3(C2=O)C(=O)N(CC(O)=O)c2ccc(Cl)cc32)cs1
Show InChI InChI=1S/C18H14ClN3O5S/c1-9-20-11(8-28-9)6-22-14(23)5-18(17(22)27)12-4-10(19)2-3-13(12)21(16(18)26)7-15(24)25/h2-4,8H,5-7H2,1H3,(H,24,25)
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 38n/an/an/a 236n/an/an/an/a



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21578
PNG
(2-{5-chloro-1'-[(2-chloro-5-fluorophenyl)methyl]-1...)
Show SMILES OC(=O)CN1C(=O)C2(CC(=O)N(Cc3cc(F)ccc3Cl)C2=O)c2cc(Cl)ccc12
Show InChI InChI=1S/C20H13Cl2FN2O5/c21-11-1-4-15-13(6-11)20(18(29)24(15)9-17(27)28)7-16(26)25(19(20)30)8-10-5-12(23)2-3-14(10)22/h1-6H,7-9H2,(H,27,28)
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 43n/an/an/an/an/an/an/an/a



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21593
PNG
(2-{5-chloro-1'-[(3,5-dimethyl-1,2-oxazol-4-yl)meth...)
Show SMILES Cc1noc(C)c1CN1C(=O)CC2(C1=O)C(=O)N(CC(O)=O)c1ccc(Cl)cc21
Show InChI InChI=1S/C19H16ClN3O6/c1-9-12(10(2)29-21-9)7-23-15(24)6-19(18(23)28)13-5-11(20)3-4-14(13)22(17(19)27)8-16(25)26/h3-5H,6-8H2,1-2H3,(H,25,26)
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 51n/an/an/a 220n/an/an/an/a



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21586
PNG
(2-(5-chloro-1'-{[2-(4-chlorophenyl)-1,3-thiazol-4-...)
Show SMILES OC(=O)CN1C(=O)C2(CC(=O)N(Cc3csc(n3)-c3ccc(Cl)cc3)C2=O)c2cc(Cl)ccc12
Show InChI InChI=1S/C23H15Cl2N3O5S/c24-13-3-1-12(2-4-13)20-26-15(11-34-20)9-28-18(29)8-23(22(28)33)16-7-14(25)5-6-17(16)27(21(23)32)10-19(30)31/h1-7,11H,8-10H2,(H,30,31)
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 55n/an/an/an/an/an/an/an/a



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21568
PNG
(2-{5-chloro-1'-[(3-chlorophenyl)methyl]-1,2-dihydr...)
Show SMILES OC(=O)CN1C(=O)C2(CC(=O)N(Cc3cccc(Cl)c3)C2=O)c2cc(Cl)ccc12
Show InChI InChI=1S/C20H14Cl2N2O5/c21-12-3-1-2-11(6-12)9-24-16(25)8-20(19(24)29)14-7-13(22)4-5-15(14)23(18(20)28)10-17(26)27/h1-7H,8-10H2,(H,26,27)
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 68 -40.5n/an/a 122n/an/a7.422



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21607
PNG
(2-[(3R)-5-chloro-1'-[(3-methoxyphenyl)methyl]-1,2-...)
Show SMILES COc1cccc(CN2C(=O)C[C@@]3(C(=O)N(CC(O)=O)c4ccc(Cl)cc34)C2=O)c1 |r|
Show InChI InChI=1S/C21H17ClN2O6/c1-30-14-4-2-3-12(7-14)10-24-17(25)9-21(20(24)29)15-8-13(22)5-6-16(15)23(19(21)28)11-18(26)27/h2-8H,9-11H2,1H3,(H,26,27)/t21-/m1/s1
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 72n/an/an/an/an/an/an/an/a



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21601
PNG
(2-[(3R)-1'-benzyl-5-chloro-1,2-dihydrospiro[indole...)
Show SMILES OC(=O)CN1C(=O)[C@@]2(CC(=O)N(Cc3ccccc3)C2=O)c2cc(Cl)ccc12 |r|
Show InChI InChI=1S/C20H15ClN2O5/c21-13-6-7-15-14(8-13)20(18(27)22(15)11-17(25)26)9-16(24)23(19(20)28)10-12-4-2-1-3-5-12/h1-8H,9-11H2,(H,25,26)/t20-/m1/s1
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 81n/an/an/an/an/an/an/an/a



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Mus musculus (mouse))		BDBM21611
PNG
(2-[(3S)-5-chloro-1'-[(5-chloro-2-fluorophenyl)meth...)
Show SMILES OC(=O)CN1C(=O)[C@]2(CN(Cc3cc(Cl)ccc3F)C(=O)C2)c2cc(Cl)ccc12 |r|
Show InChI InChI=1S/C20H15Cl2FN2O4/c21-12-1-3-15(23)11(5-12)8-24-10-20(7-17(24)26)14-6-13(22)2-4-16(14)25(19(20)29)9-18(27)28/h1-6H,7-10H2,(H,27,28)/t20-/m1/s1
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 88n/an/an/an/an/an/an/an/a



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21577
PNG
(2-{5-chloro-1'-[(3,4-difluorophenyl)methyl]-1,2-di...)
Show SMILES OC(=O)CN1C(=O)C2(CC(=O)N(Cc3ccc(F)c(F)c3)C2=O)c2cc(Cl)ccc12
Show InChI InChI=1S/C20H13ClF2N2O5/c21-11-2-4-15-12(6-11)20(18(29)24(15)9-17(27)28)7-16(26)25(19(20)30)8-10-1-3-13(22)14(23)5-10/h1-6H,7-9H2,(H,27,28)
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 89n/an/an/an/an/an/an/an/a



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21567
PNG
(2-{5-chloro-1'-[(4-fluorophenyl)methyl]-1,2-dihydr...)
Show SMILES OC(=O)CN1C(=O)C2(CC(=O)N(Cc3ccc(F)cc3)C2=O)c2cc(Cl)ccc12
Show InChI InChI=1S/C20H14ClFN2O5/c21-12-3-6-15-14(7-12)20(18(28)23(15)10-17(26)27)8-16(25)24(19(20)29)9-11-1-4-13(22)5-2-11/h1-7H,8-10H2,(H,26,27)
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 96 -39.7n/an/a 182n/an/a7.422



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21569
PNG
(2-{5-chloro-1'-[(4-chlorophenyl)methyl]-1,2-dihydr...)
Show SMILES OC(=O)CN1C(=O)C2(CC(=O)N(Cc3ccc(Cl)cc3)C2=O)c2cc(Cl)ccc12
Show InChI InChI=1S/C20H14Cl2N2O5/c21-12-3-1-11(2-4-12)9-24-16(25)8-20(19(24)29)14-7-13(22)5-6-15(14)23(18(20)28)10-17(26)27/h1-7H,8-10H2,(H,26,27)
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 115 -39.2n/an/an/an/an/a7.422



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21572
PNG
(2-{5-chloro-1'-[(4-phenoxyphenyl)methyl]-1,2-dihyd...)
Show SMILES OC(=O)CN1C(=O)C2(CC(=O)N(Cc3ccc(Oc4ccccc4)cc3)C2=O)c2cc(Cl)ccc12
Show InChI InChI=1S/C26H19ClN2O6/c27-17-8-11-21-20(12-17)26(24(33)28(21)15-23(31)32)13-22(30)29(25(26)34)14-16-6-9-19(10-7-16)35-18-4-2-1-3-5-18/h1-12H,13-15H2,(H,31,32)
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 143n/an/an/an/an/an/an/an/a



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Mus musculus (mouse))		BDBM21543
PNG
(2-{1'-benzyl-5-chloro-1,2-dihydrospiro[indole-3,3'...)
Show SMILES OC(=O)CN1C(=O)C2(CC(=O)N(Cc3ccccc3)C2=O)c2cc(Cl)ccc12
Show InChI InChI=1S/C20H15ClN2O5/c21-13-6-7-15-14(8-13)20(18(27)22(15)11-17(25)26)9-16(24)23(19(20)28)10-12-4-2-1-3-5-12/h1-8H,9-11H2,(H,25,26)
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 150 -38.6n/an/an/an/an/a7.422



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21582
PNG
(2-{5-chloro-1'-[(3-fluoro-4-methoxyphenyl)methyl]-...)
Show SMILES COc1ccc(CN2C(=O)CC3(C2=O)C(=O)N(CC(O)=O)c2ccc(Cl)cc32)cc1F
Show InChI InChI=1S/C21H16ClFN2O6/c1-31-16-5-2-11(6-14(16)23)9-25-17(26)8-21(20(25)30)13-7-12(22)3-4-15(13)24(19(21)29)10-18(27)28/h2-7H,8-10H2,1H3,(H,27,28)
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 154n/an/an/an/an/an/an/an/a



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21571
PNG
(2-{5-chloro-1'-[(3-methoxyphenyl)methyl]-1,2-dihyd...)
Show SMILES COc1cccc(CN2C(=O)CC3(C(=O)N(CC(O)=O)c4ccc(Cl)cc34)C2=O)c1
Show InChI InChI=1S/C21H17ClN2O6/c1-30-14-4-2-3-12(7-14)10-24-17(25)9-21(20(24)29)15-8-13(22)5-6-16(15)23(19(21)28)11-18(26)27/h2-8H,9-11H2,1H3,(H,26,27)
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 169n/an/an/an/an/an/an/an/a



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21543
PNG
(2-{1'-benzyl-5-chloro-1,2-dihydrospiro[indole-3,3'...)
Show SMILES OC(=O)CN1C(=O)C2(CC(=O)N(Cc3ccccc3)C2=O)c2cc(Cl)ccc12
Show InChI InChI=1S/C20H15ClN2O5/c21-13-6-7-15-14(8-13)20(18(27)22(15)11-17(25)26)9-16(24)23(19(20)28)10-12-4-2-1-3-5-12/h1-8H,9-11H2,(H,25,26)
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 196 -37.9n/an/a 418n/an/a7.422



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21587
PNG
(2-(5-chloro-1'-{[5-(4-methoxyphenyl)-1,2,4-oxadiaz...)
Show SMILES COc1ccc(cc1)-c1nc(CN2C(=O)CC3(C2=O)C(=O)N(CC(O)=O)c2ccc(Cl)cc32)no1
Show InChI InChI=1S/C23H17ClN4O7/c1-34-14-5-2-12(3-6-14)20-25-17(26-35-20)10-28-18(29)9-23(22(28)33)15-8-13(24)4-7-16(15)27(21(23)32)11-19(30)31/h2-8H,9-11H2,1H3,(H,30,31)
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 212n/an/an/an/an/an/an/an/a



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21570
PNG
(2-{5-chloro-1'-[(2-methoxyphenyl)methyl]-1,2-dihyd...)
Show SMILES COc1ccccc1CN1C(=O)CC2(C(=O)N(CC(O)=O)c3ccc(Cl)cc23)C1=O
Show InChI InChI=1S/C21H17ClN2O6/c1-30-16-5-3-2-4-12(16)10-24-17(25)9-21(20(24)29)14-8-13(22)6-7-15(14)23(19(21)28)11-18(26)27/h2-8H,9-11H2,1H3,(H,26,27)
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 233n/an/an/an/an/an/an/an/a



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21563
PNG
(2-[5-chloro-1'-(2-phenylethyl)-1,2-dihydrospiro[in...)
Show SMILES OC(=O)CN1C(=O)C2(CC(=O)N(CCc3ccccc3)C2=O)c2cc(Cl)ccc12
Show InChI InChI=1S/C21H17ClN2O5/c22-14-6-7-16-15(10-14)21(20(29)24(16)12-18(26)27)11-17(25)23(19(21)28)9-8-13-4-2-1-3-5-13/h1-7,10H,8-9,11-12H2,(H,26,27)
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 267 -37.1n/an/an/an/an/a7.422



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21609
PNG
(2-[(3S)-5-chloro-1'-[(5-chloro-2-fluorophenyl)meth...)
Show SMILES OC(=O)CN1C(=O)[C@]2(CC(=O)N(Cc3cc(Cl)ccc3F)C2=O)c2cc(Cl)ccc12 |r|
Show InChI InChI=1S/C20H13Cl2FN2O5/c21-11-1-3-14(23)10(5-11)8-25-16(26)7-20(19(25)30)13-6-12(22)2-4-15(13)24(18(20)29)9-17(27)28/h1-6H,7-9H2,(H,27,28)/t20-/m0/s1
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 302n/an/an/an/an/an/an/an/a



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21591
PNG
(2-[5-chloro-1'-(furan-3-ylmethyl)-1,2-dihydrospiro...)
Show SMILES OC(=O)CN1C(=O)C2(CC(=O)N(Cc3ccoc3)C2=O)c2cc(Cl)ccc12
Show InChI InChI=1S/C18H13ClN2O6/c19-11-1-2-13-12(5-11)18(16(25)20(13)8-15(23)24)6-14(22)21(17(18)26)7-10-3-4-27-9-10/h1-5,9H,6-8H2,(H,23,24)
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 318n/an/an/an/an/an/an/an/a



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21565
PNG
(2-[5-chloro-1'-(1-phenylethyl)-1,2-dihydrospiro[in...)
Show SMILES CC(N1C(=O)CC2(C(=O)N(CC(O)=O)c3ccc(Cl)cc23)C1=O)c1ccccc1
Show InChI InChI=1S/C21H17ClN2O5/c1-12(13-5-3-2-4-6-13)24-17(25)10-21(20(24)29)15-9-14(22)7-8-16(15)23(19(21)28)11-18(26)27/h2-9,12H,10-11H2,1H3,(H,26,27)
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 356 -36.4n/an/an/an/an/a7.422



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21589
PNG
(2-[5-chloro-1'-(1,3-oxazol-2-ylmethyl)-1,2-dihydro...)
Show SMILES OC(=O)CN1C(=O)C2(CC(=O)N(Cc3ncco3)C2=O)c2cc(Cl)ccc12
Show InChI InChI=1S/C17H12ClN3O6/c18-9-1-2-11-10(5-9)17(15(25)20(11)8-14(23)24)6-13(22)21(16(17)26)7-12-19-3-4-27-12/h1-5H,6-8H2,(H,23,24)
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 438n/an/an/an/an/an/an/an/a



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Mus musculus (mouse))		BDBM21597
PNG
(2-{1'-benzyl-5-chloro-1,2-dihydrospiro[indole-3,3'...)
Show SMILES OC(=O)CN1C(=O)C2(CN(Cc3ccccc3)C(=O)C2)c2cc(Cl)ccc12
Show InChI InChI=1S/C20H17ClN2O4/c21-14-6-7-16-15(8-14)20(19(27)23(16)11-18(25)26)9-17(24)22(12-20)10-13-4-2-1-3-5-13/h1-8H,9-12H2,(H,25,26)
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 480n/an/an/an/an/an/an/an/a



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21590
PNG
(2-{5-chloro-1'-[(5-cyclopropyl-1,3,4-thiadiazol-2-...)
Show SMILES OC(=O)CN1C(=O)C2(CC(=O)N(Cc3nnc(s3)C3CC3)C2=O)c2cc(Cl)ccc12
Show InChI InChI=1S/C19H15ClN4O5S/c20-10-3-4-12-11(5-10)19(17(28)23(12)8-15(26)27)6-14(25)24(18(19)29)7-13-21-22-16(30-13)9-1-2-9/h3-5,9H,1-2,6-8H2,(H,26,27)
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 497n/an/an/an/an/an/an/an/a



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21592
PNG
(2-[5-chloro-1'-(1H-indol-3-ylmethyl)-1,2-dihydrosp...)
Show SMILES OC(=O)CN1C(=O)C2(CC(=O)N(Cc3c[nH]c4ccccc34)C2=O)c2cc(Cl)ccc12
Show InChI InChI=1S/C22H16ClN3O5/c23-13-5-6-17-15(7-13)22(20(30)25(17)11-19(28)29)8-18(27)26(21(22)31)10-12-9-24-16-4-2-1-3-14(12)16/h1-7,9,24H,8,10-11H2,(H,28,29)
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 596n/an/an/an/an/an/an/an/a



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21612
PNG
(2-[(3R)-5-chloro-1'-[(5-chloro-2-fluorophenyl)meth...)
Show SMILES OC(=O)CN1C(=O)[C@@]2(CN(Cc3cc(Cl)ccc3F)C(=O)C2)c2cc(Cl)ccc12 |r|
Show InChI InChI=1S/C20H15Cl2FN2O4/c21-12-1-3-15(23)11(5-12)8-24-10-20(7-17(24)26)14-6-13(22)2-4-16(14)25(19(20)29)9-18(27)28/h1-6H,7-10H2,(H,27,28)/t20-/m0/s1
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 683n/an/an/an/an/an/an/an/a



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21597
PNG
(2-{1'-benzyl-5-chloro-1,2-dihydrospiro[indole-3,3'...)
Show SMILES OC(=O)CN1C(=O)C2(CN(Cc3ccccc3)C(=O)C2)c2cc(Cl)ccc12
Show InChI InChI=1S/C20H17ClN2O4/c21-14-6-7-16-15(8-14)20(19(27)23(16)11-18(25)26)9-17(24)22(12-20)10-13-4-2-1-3-5-13/h1-8H,9-12H2,(H,25,26)
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 702n/an/an/an/an/an/an/an/a



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21545
PNG
(2-{1'-benzyl-5-fluoro-1,2-dihydrospiro[indole-3,3'...)
Show SMILES OC(=O)CN1C(=O)C2(CC(=O)N(Cc3ccccc3)C2=O)c2cc(F)ccc12
Show InChI InChI=1S/C20H15FN2O5/c21-13-6-7-15-14(8-13)20(18(27)22(15)11-17(25)26)9-16(24)23(19(20)28)10-12-4-2-1-3-5-12/h1-8H,9-11H2,(H,25,26)
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 712 -34.7n/an/an/an/an/a7.422



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21564
PNG
(2-{5-chloro-1'-[(2E)-3-phenylprop-2-en-1-yl]-1,2-d...)
Show SMILES OC(=O)CN1C(=O)C2(CC(=O)N(C\C=C\c3ccccc3)C2=O)c2cc(Cl)ccc12
Show InChI InChI=1S/C22H17ClN2O5/c23-15-8-9-17-16(11-15)22(21(30)25(17)13-19(27)28)12-18(26)24(20(22)29)10-4-7-14-5-2-1-3-6-14/h1-9,11H,10,12-13H2,(H,27,28)/b7-4+
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 747 -34.6n/an/an/an/an/a7.422



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21561
PNG
(4-{5-chloro-1'-[(4-chlorophenyl)methyl]-1,2-dihydr...)
Show SMILES OC(=O)CCCN1C(=O)C2(CC(=O)N(Cc3ccc(Cl)cc3)C2=O)c2cc(Cl)ccc12
Show InChI InChI=1S/C22H18Cl2N2O5/c23-14-5-3-13(4-6-14)12-26-18(27)11-22(21(26)31)16-10-15(24)7-8-17(16)25(20(22)30)9-1-2-19(28)29/h3-8,10H,1-2,9,11-12H2,(H,28,29)
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 758 -34.6n/an/a 5.60E+3n/an/a7.422



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21550
PNG
(4-[5-chloro-1'-(prop-2-en-1-yl)-1,2-dihydrospiro[i...)
Show SMILES OC(=O)CCCN1C(=O)C2(CC(=O)N(CC=C)C2=O)c2cc(Cl)ccc12
Show InChI InChI=1S/C18H17ClN2O5/c1-2-7-21-14(22)10-18(17(21)26)12-9-11(19)5-6-13(12)20(16(18)25)8-3-4-15(23)24/h2,5-6,9H,1,3-4,7-8,10H2,(H,23,24)
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 769 -34.5n/an/an/an/an/a7.422



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21606
PNG
(2-[(3S)-5-chloro-1'-[(3-chlorophenyl)methyl]-1,2-d...)
Show SMILES OC(=O)CN1C(=O)[C@]2(CC(=O)N(Cc3cccc(Cl)c3)C2=O)c2cc(Cl)ccc12 |r|
Show InChI InChI=1S/C20H14Cl2N2O5/c21-12-3-1-2-11(6-12)9-24-16(25)8-20(19(24)29)14-7-13(22)4-5-15(14)23(18(20)28)10-17(26)27/h1-7H,8-10H2,(H,26,27)/t20-/m0/s1
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 870n/an/an/an/an/an/an/an/a



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21604
PNG
(2-[(3S)-5-chloro-1'-[(2-fluorophenyl)methyl]-1,2-d...)
Show SMILES OC(=O)CN1C(=O)[C@]2(CC(=O)N(Cc3ccccc3F)C2=O)c2cc(Cl)ccc12 |r|
Show InChI InChI=1S/C20H14ClFN2O5/c21-12-5-6-15-13(7-12)20(18(28)23(15)10-17(26)27)8-16(25)24(19(20)29)9-11-3-1-2-4-14(11)22/h1-7H,8-10H2,(H,26,27)/t20-/m0/s1
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 926n/an/an/an/an/an/an/an/a



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21560
PNG
(4-{5-chloro-1'-[(4-methoxyphenyl)methyl]-1,2-dihyd...)
Show SMILES COc1ccc(CN2C(=O)CC3(C(=O)N(CCCC(O)=O)c4ccc(Cl)cc34)C2=O)cc1
Show InChI InChI=1S/C23H21ClN2O6/c1-32-16-7-4-14(5-8-16)13-26-19(27)12-23(22(26)31)17-11-15(24)6-9-18(17)25(21(23)30)10-2-3-20(28)29/h4-9,11H,2-3,10,12-13H2,1H3,(H,28,29)
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 960 -34.0n/an/an/an/an/a7.422



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21608
PNG
(2-[(3S)-5-chloro-1'-[(3-methoxyphenyl)methyl]-1,2-...)
Show SMILES COc1cccc(CN2C(=O)C[C@]3(C(=O)N(CC(O)=O)c4ccc(Cl)cc34)C2=O)c1 |r|
Show InChI InChI=1S/C21H17ClN2O6/c1-30-14-4-2-3-12(7-14)10-24-17(25)9-21(20(24)29)15-8-13(22)5-6-16(15)23(19(21)28)11-18(26)27/h2-8H,9-11H2,1H3,(H,26,27)/t21-/m0/s1
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 1.17E+3n/an/an/an/an/an/an/an/a



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21583
PNG
(2-{5-chloro-1'-[(1-methyl-1H-1,2,3-benzotriazol-5-...)
Show SMILES Cn1nnc2cc(CN3C(=O)CC4(C3=O)C(=O)N(CC(O)=O)c3ccc(Cl)cc43)ccc12
Show InChI InChI=1S/C21H16ClN5O5/c1-25-16-4-2-11(6-14(16)23-24-25)9-27-17(28)8-21(20(27)32)13-7-12(22)3-5-15(13)26(19(21)31)10-18(29)30/h2-7H,8-10H2,1H3,(H,29,30)
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 1.30E+3n/an/an/an/an/an/an/an/a



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21588
PNG
(2-{1'-[(5-tert-butyl-1,2,4-oxadiazol-3-yl)methyl]-...)
Show SMILES CC(C)(C)c1nc(CN2C(=O)CC3(C2=O)C(=O)N(CC(O)=O)c2ccc(Cl)cc32)no1
Show InChI InChI=1S/C20H19ClN4O6/c1-19(2,3)16-22-13(23-31-16)8-25-14(26)7-20(18(25)30)11-6-10(21)4-5-12(11)24(17(20)29)9-15(27)28/h4-6H,7-9H2,1-3H3,(H,27,28)
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 1.34E+3n/an/an/an/an/an/an/an/a



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21553
PNG
(2-[5-chloro-1'-(2-methoxyethyl)-1,2-dihydrospiro[i...)
Show SMILES COCCN1C(=O)CC2(C1=O)C(=O)N(CC(O)=O)c1ccc(Cl)cc21
Show InChI InChI=1S/C16H15ClN2O6/c1-25-5-4-18-12(20)7-16(14(18)23)10-6-9(17)2-3-11(10)19(15(16)24)8-13(21)22/h2-3,6H,4-5,7-8H2,1H3,(H,21,22)
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 1.45E+3 -33.0n/an/an/an/an/a7.422



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21573
PNG
(2-{5-chloro-1'-[(4-methanesulfonylphenyl)methyl]-1...)
Show SMILES CS(=O)(=O)c1ccc(CN2C(=O)CC3(C2=O)C(=O)N(CC(O)=O)c2ccc(Cl)cc32)cc1
Show InChI InChI=1S/C21H17ClN2O7S/c1-32(30,31)14-5-2-12(3-6-14)10-24-17(25)9-21(20(24)29)15-8-13(22)4-7-16(15)23(19(21)28)11-18(26)27/h2-8H,9-11H2,1H3,(H,26,27)
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 1.51E+3n/an/an/an/an/an/an/an/a



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21562
PNG
(1'-benzyl-5-chloro-1-(1H-1,2,3,4-tetrazol-5-ylmeth...)
Show SMILES Clc1ccc2N(Cc3nnn[nH]3)C(=O)C3(CC(=O)N(Cc4ccccc4)C3=O)c2c1
Show InChI InChI=1S/C20H15ClN6O3/c21-13-6-7-15-14(8-13)20(18(29)26(15)11-16-22-24-25-23-16)9-17(28)27(19(20)30)10-12-4-2-1-3-5-12/h1-8H,9-11H2,(H,22,23,24,25)
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 1.54E+3 -32.8n/an/an/an/an/a7.422



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21554
PNG
(4-{1'-benzyl-5-chloro-1,2-dihydrospiro[indole-3,3'...)
Show SMILES OC(=O)CCCN1C(=O)C2(CC(=O)N(Cc3ccccc3)C2=O)c2cc(Cl)ccc12
Show InChI InChI=1S/C22H19ClN2O5/c23-15-8-9-17-16(11-15)22(20(29)24(17)10-4-7-19(27)28)12-18(26)25(21(22)30)13-14-5-2-1-3-6-14/h1-3,5-6,8-9,11H,4,7,10,12-13H2,(H,27,28)
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 1.66E+3 -32.7n/an/an/an/an/a7.422



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21559
PNG
(4-{5-chloro-1'-[(2-fluorophenyl)methyl]-1,2-dihydr...)
Show SMILES OC(=O)CCCN1C(=O)C2(CC(=O)N(Cc3ccccc3F)C2=O)c2cc(Cl)ccc12
Show InChI InChI=1S/C22H18ClFN2O5/c23-14-7-8-17-15(10-14)22(20(30)25(17)9-3-6-19(28)29)11-18(27)26(21(22)31)12-13-4-1-2-5-16(13)24/h1-2,4-5,7-8,10H,3,6,9,11-12H2,(H,28,29)
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 1.76E+3 -32.5n/an/a 2.20E+3n/an/a7.422



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21602
PNG
(2-[(3S)-1'-benzyl-5-chloro-1,2-dihydrospiro[indole...)
Show SMILES OC(=O)CN1C(=O)[C@]2(CC(=O)N(Cc3ccccc3)C2=O)c2cc(Cl)ccc12 |r|
Show InChI InChI=1S/C20H15ClN2O5/c21-13-6-7-15-14(8-13)20(18(27)22(15)11-17(25)26)9-16(24)23(19(20)28)10-12-4-2-1-3-5-12/h1-8H,9-11H2,(H,25,26)/t20-/m0/s1
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 2.04E+3n/an/an/an/an/an/an/an/a



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21600
PNG
(2-{5-chloro-1'-[(5-methyl-3-phenyl-1,2-oxazol-4-yl...)
Show SMILES Cc1onc(c1CN1CCC2(C1=O)C(=O)N(CC(O)=O)c1ccc(Cl)cc21)-c1ccccc1
Show InChI InChI=1S/C24H20ClN3O5/c1-14-17(21(26-33-14)15-5-3-2-4-6-15)12-27-10-9-24(22(27)31)18-11-16(25)7-8-19(18)28(23(24)32)13-20(29)30/h2-8,11H,9-10,12-13H2,1H3,(H,29,30)
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 2.24E+3n/an/an/an/an/an/an/an/a



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21546
PNG
(2-{1'-benzyl-5-methoxy-1,2-dihydrospiro[indole-3,3...)
Show SMILES COc1ccc2N(CC(O)=O)C(=O)C3(CC(=O)N(Cc4ccccc4)C3=O)c2c1
Show InChI InChI=1S/C21H18N2O6/c1-29-14-7-8-16-15(9-14)21(19(27)22(16)12-18(25)26)10-17(24)23(20(21)28)11-13-5-3-2-4-6-13/h2-9H,10-12H2,1H3,(H,25,26)
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 2.74E+3 -31.4n/an/an/an/an/a7.422



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21549
PNG
(2-{5-fluoro-1'-[(2-methoxyethoxy)methyl]-1,2-dihyd...)
Show SMILES COCCOCN1C(=O)CC2(C1=O)C(=O)N(CC(O)=O)c1ccc(F)cc21
Show InChI InChI=1S/C17H17FN2O7/c1-26-4-5-27-9-20-13(21)7-17(16(20)25)11-6-10(18)2-3-12(11)19(15(17)24)8-14(22)23/h2-3,6H,4-5,7-9H2,1H3,(H,22,23)
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 3.83E+3 -30.6n/an/an/an/an/a7.422



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21556
PNG
(4-[5-fluoro-1'-(prop-2-en-1-yl)-1,2-dihydrospiro[i...)
Show SMILES OC(=O)CCCN1C(=O)C2(CC(=O)N(CC=C)C2=O)c2cc(F)ccc12
Show InChI InChI=1S/C18H17FN2O5/c1-2-7-21-14(22)10-18(17(21)26)12-9-11(19)5-6-13(12)20(16(18)25)8-3-4-15(23)24/h2,5-6,9H,1,3-4,7-8,10H2,(H,23,24)
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 4.13E+3 -30.4n/an/an/an/an/a7.422



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21557
PNG
(4-{1'-benzyl-5-fluoro-1,2-dihydrospiro[indole-3,3'...)
Show SMILES OC(=O)CCCN1C(=O)C2(CC(=O)N(Cc3ccccc3)C2=O)c2cc(F)ccc12
Show InChI InChI=1S/C22H19FN2O5/c23-15-8-9-17-16(11-15)22(20(29)24(17)10-4-7-19(27)28)12-18(26)25(21(22)30)13-14-5-2-1-3-6-14/h1-3,5-6,8-9,11H,4,7,10,12-13H2,(H,27,28)
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 4.17E+3 -30.4n/an/an/an/an/a7.422



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21548
PNG
(2-{5-chloro-1'-[(dimethylcarbamoyl)methyl]-1,2-dih...)
Show SMILES CN(C)C(=O)CN1C(=O)CC2(C1=O)C(=O)N(CC(O)=O)c1ccc(Cl)cc21
Show InChI InChI=1S/C17H16ClN3O6/c1-19(2)13(23)7-21-12(22)6-17(16(21)27)10-5-9(18)3-4-11(10)20(15(17)26)8-14(24)25/h3-5H,6-8H2,1-2H3,(H,24,25)
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 4.67E+3 -30.1n/an/an/an/an/a7.422



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21552
PNG
(2-{5-chloro-1'-methyl-1,2-dihydrospiro[indole-3,3'...)
Show SMILES CN1C(=O)CC2(C1=O)C(=O)N(CC(O)=O)c1ccc(Cl)cc21
Show InChI InChI=1S/C14H11ClN2O5/c1-16-10(18)5-14(12(16)21)8-4-7(15)2-3-9(8)17(13(14)22)6-11(19)20/h2-4H,5-6H2,1H3,(H,19,20)
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 7.62E+3 -28.9n/an/an/an/an/a7.422



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21555
PNG
(4-{5-fluoro-1'-methyl-1,2-dihydrospiro[indole-3,3'...)
Show SMILES CN1C(=O)CC2(C1=O)C(=O)N(CCCC(O)=O)c1ccc(F)cc21
Show InChI InChI=1S/C16H15FN2O5/c1-18-12(20)8-16(14(18)23)10-7-9(17)4-5-11(10)19(15(16)24)6-2-3-13(21)22/h4-5,7H,2-3,6,8H2,1H3,(H,21,22)
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 8.90E+3 -28.5n/an/an/an/an/a7.422



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21551
PNG
(1'-benzyl-5-chloro-1-methyl-1,2-dihydrospiro[indol...)
Show SMILES CN1C(=O)C2(CC(=O)N(Cc3ccccc3)C2=O)c2cc(Cl)ccc12
Show InChI InChI=1S/C19H15ClN2O3/c1-21-15-8-7-13(20)9-14(15)19(17(21)24)10-16(23)22(18(19)25)11-12-5-3-2-4-6-12/h2-9H,10-11H2,1H3
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 1.16E+4 -27.9n/an/an/an/an/a7.422



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21547
PNG
(2-{1'-[(dimethylcarbamoyl)methyl]-5-fluoro-1,2-dih...)
Show SMILES CN(C)C(=O)CN1C(=O)CC2(C1=O)C(=O)N(CC(O)=O)c1ccc(F)cc21
Show InChI InChI=1S/C17H16FN3O6/c1-19(2)13(23)7-21-12(22)6-17(16(21)27)10-5-9(18)3-4-11(10)20(15(17)26)8-14(24)25/h3-5H,6-8H2,1-2H3,(H,24,25)
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>3.00E+4>-25.6n/an/an/an/an/a7.422



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM21558
PNG
(Spiro-indolinone analogue, 51 | ethyl 2-{1'-benzyl...)
Show SMILES CCOC(=O)CN1C(=O)C2(CC(=O)N(Cc3ccccc3)C2=O)c2cc(Cl)ccc12
Show InChI InChI=1S/C22H19ClN2O5/c1-2-30-19(27)13-24-17-9-8-15(23)10-16(17)22(20(24)28)11-18(26)25(21(22)29)12-14-6-4-3-5-7-14/h3-10H,2,11-13H2,1H3
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>3.00E+4>-25.6n/an/an/an/an/a7.422



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...

J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%