The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
1560440 |
42 |
Synthesis and muscarinic activities of quinuclidin-3-yltriazole and -tetrazole derivatives. |
Smithkline Beecham Pharmaceuticals |
1732545 |
27 |
Phenyl-substituted analogues of oxotremorine as muscarinic antagonists. |
University of Uppsala |
1619616 |
94 |
Substituent variation in azabicyclic triazole- and tetrazole-based muscarinic receptor ligands. |
Smithkline Beecham Pharmaceuticals |
1895293 |
44 |
Comparison of azabicyclic esters and oxadiazoles as ligands for the muscarinic receptor. |
Smithkline Beecham Pharmaceuticals |
1875333 |
132 |
Cholinergic activity of acetylenic imidazoles and related compounds. |
Upjohn |
1995893 |
81 |
Muscarinic cholinergic agonists and antagonists of the 3-(3-alkyl-1,2,4-oxadiazol-5-yl)-1,2,5,6-tetrahydropyridine type. Synthesis and structure-activity relationships. |
Ferrosan |
2299626 |
18 |
Beta-lactam analogues of oxotremorine. 3- and 4-methyl-substituted 2-azetidinones. |
University of Uppsala |
2258905 |
135 |
Chemical and biochemical studies of 2-propynylpyrrolidine derivatives. Restricted-rotation analogues of N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide (BM-5). |
American Cyanamid |
2296026 |
12 |
Synthesis of some 3-(1-azabicyclo[2.2.2]octyl) 3-amino-2-hydroxy-2-phenylpropionates: profile of antimuscarinic efficacy and selectivity. |
Nova Pharmaceutical |
2724292 |
120 |
Regional differences in the binding of selective muscarinic receptor antagonists in rat brain: comparison with minimum-energy conformations. |
University of Toledo |
2785211 |
18 |
Synthesis and biological evaluation of [125I]- and [123I]-4-iododexetimide, a potent muscarinic cholinergic receptor antagonist. |
Johns Hopkins Medical Institutions |
2704032 |
10 |
Conformationally restricted analogues of the muscarinic agent N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide. |
University of Uppsala |
3351856 |
3 |
Synthesis and antiulcer activity of 5,11-dihydro[1]benzoxepino[3,4-b]pyridines. |
Kyowa Hakko Kogyo |
3336015 |
8 |
Dimethylsulfonium and thiolanium analogues of the muscarinic agent oxotremorine. |
University of California |
3039133 |
9 |
Tricyclic compounds as selective antimuscarinics. 1. Structural requirements for selectivity toward the muscarinic acetylcholine receptor in a series of pirenzepine and imipramine analogues. |
TBA |
3806613 |
2 |
Molecular modification of anticholinergics as probes for muscarinic receptors. 3. Conformationally restricted analogues of benactyzine. |
TBA |
2866248 |
8 |
Examination of a series of 8-[3-[bis(4-fluorophenyl)amino]propyl]-1-aryl-1,3,8- triazaspiro[4.5]decan-4-ones as potential antipsychotic agents. |
TBA |
7108902 |
18 |
Affinity of 10-(4-methylpiperazino)dibenz[b,f]oxepins for clozapine and spiroperidol binding sites in rat brain. |
TBA |
6128416 |
29 |
Effects of conformationally restricted 4-piperazinyl-10H-thienobenzodiazepine neuroleptics on central dopaminergic and cholinergic systems. |
TBA |
7288815 |
18 |
Synthesis of clozapine analogues and their affinity for clozapine and spiroperidol binding sites in rat brain. |
TBA |
6249933 |
12 |
Conformationally restricted tricyclic antidepressants. 1. Octahydrodibenzazepinonaphthyridines as rigid imipramine analogues. |
TBA |
27939174 |
84 |
Challenges in the development of an M |
Vanderbilt University Medical Center |
27173801 |
29 |
Further optimization of the M1 PAM VU0453595: Discovery of novel heterobicyclic core motifs with improved CNS penetration. |
Vanderbilt University Medical Center |
26191354 |
20 |
Pyrrolopyridine or Pyrazolopyridine Derivatives. |
Temple University |
25147929 |
105 |
Development of a highly potent, novel M5 positive allosteric modulator (PAM) demonstrating CNS exposure: 1-((1H-indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piperidine-4-carboxamide (ML380). |
Vanderbilt University Medical Center |
24837158 |
60 |
Novel quinuclidinyl heteroarylcarbamate derivatives as muscarinic receptor antagonists. |
Astellas Pharma |
23200253 |
67 |
Further exploration of M1 allosteric agonists: subtle structural changes abolish M1 allosteric agonism and result in pan-mAChR orthosteric antagonism. |
Vanderbilt University Medical Center |
23177787 |
59 |
Discovery of a selective M4 positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophrenia. |
Vanderbilt University Medical Center |
| 7 |
6-Carboxymethyl-2-azabicyclo[2.2.1]heptane enantiomers: muscarinic activities of rigid analogues of arecoline |
TBA |
9767650 |
48 |
Universal template approach to drug design: polyamines as selective muscarinic receptor antagonists. |
University of Bologna |
12392730 |
10 |
Synthesis and muscarinic M(2) subtype antagonistic activity of enantiomeric pairs of 3-demethylhimbacine (3-norhimbacine) and its C(4)-epimer. |
Kyorin Pharmaceutical |
12270166 |
8 |
Synthesis and muscarinic M2 subtype antagonistic activity of unnatural ent-himbacine and an enantiomeric pair of (2'S,6'R)-diepihimbacine. |
Kyorin Pharmaceutical |
| 20 |
Design, synthesis and biological activity of some 4-DAMP- related compounds |
TBA |
22546204 |
9 |
Recent developments and biological activities of thiazolidinone derivatives: a review. |
Dr. Hari Singh Gour University |
18178088 |
64 |
Synthesis and SAR of selective muscarinic acetylcholine receptor subtype 1 (M1 mAChR) antagonists. |
Vanderbilt Institute of Chemical Biology |
17034144 |
72 |
Structure-activity relationship studies on a novel series of (S)-2beta-substituted 3alpha-[bis(4-fluoro- or 4-chlorophenyl)methoxy]tropane analogues for in vivo investigation. |
National Institute On Drug Abuse-Intramural Research Program |
16250647 |
71 |
2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization. |
Universit£ |
16220976 |
66 |
Synthesis and antimuscarinic properties of quinuclidin-3-yl 1,2,3,4-tetrahydroisoquinoline-2-carboxylate derivatives as novel muscarinic receptor antagonists. |
Astellas Pharma |
15027858 |
35 |
Synthesis and monoamine transporter binding of 2-(diarylmethoxymethyl)-3 beta-aryltropane derivatives. |
University of New Orleans |
15189035 |
67 |
Structure-activity relationships at monoamine transporters for a series of N-substituted 3alpha-(bis[4-fluorophenyl]methoxy)tropanes: comparative molecular field analysis, synthesis, and pharmacological evaluation. |
National Institute On Drug Abuse-Intramural Research Program |
12825932 |
61 |
Structure-activity relationship comparison of (S)-2beta-substituted 3alpha-(bis[4-fluorophenyl]methoxy)tropanes and (R)-2beta-substituted 3beta-(3,4-dichlorophenyl)tropanes at the dopamine transporter. |
National Institute On Drug Abuse |
11784139 |
82 |
Pyrrolo[1,3]benzothiazepine-based atypical antipsychotic agents. Synthesis, structure-activity relationship, molecular modeling, and biological studies. |
Universit£ |
11170654 |
72 |
Structure-activity relationships at monoamine transporters and muscarinic receptors for N-substituted-3alpha-(3'-chloro-, 4'-chloro-, and 4',4''-dichloro-substituted-diphenyl)methoxytropanes. |
National Institute On Drug Abuse-Intramural Research Program |
11689080 |
43 |
Synthesis and biological evaluation of tropane-like 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909) analogues. |
National Institute of Diabetes and Digestive and Kidney Diseases |
10737741 |
50 |
Highly selective chiral N-substituted 3alpha-[bis(4'-fluorophenyl)methoxy]tropane analogues for the dopamine transporter: synthesis and comparative molecular field analysis. |
National Institute On Drug Abuse-Intramural Research Program |
9464362 |
19 |
5-HT3 antagonists derived from aminopyridazine-type muscarinic M1 agonists. |
Universit£ |
9622546 |
109 |
6beta-Acetoxynortropane: a potent muscarinic agonist with apparent selectivity toward M2-receptors. |
National Institute of Diabetes and Digestive and Kidney Diseases |
9083473 |
33 |
3'-Chloro-3 alpha-(diphenylmethoxy)tropane but not 4'-chloro-3 alpha-(diphenylmethoxy)tropane produces a cocaine-like behavioral profile. |
National Institutes of Health |
9016336 |
15 |
Stereoselective synthesis and biodistribution of potent [11C]-labeled antagonists for positron emission tomography imaging of muscarinic receptors in the airways. |
Groningen University Hospital |
8765504 |
34 |
(S)-(-)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine maleate (SIB-1508Y): a novel anti-parkinsonian agent with selectivity for neuronal nicotinic acetylcholine receptors. |
Sibia Neurosciences |
7562926 |
81 |
Novel 4'-substituted and 4',4"-disubstituted 3 alpha-(diphenylmethoxy)tropane analogs as potent and selective dopamine uptake inhibitors. |
National Institutes of Health |
7562924 |
10 |
Resolution and in vitro and initial in vivo evaluation of isomers of iodine-125-labeled 1-azabicyclo[2.2.2]oct-3-yl alpha-hydroxy-alpha-(1-iodo-1-propen-3-yl)-alpha-phenylacetate: a high-affinity ligand for the muscarinic receptor. |
Oak Ridge National Laboratory (Ornl) |
7658434 |
52 |
Functionally selective M1 muscarinic agonists. 3. Side chains and azacycles contributing to functional muscarinic selectivity among pyrazinylazacycles. |
Eli Lilly |
8064804 |
3 |
Design, synthesis, and neurochemical evaluation of 2-amino-5-(alkoxycarbonyl)-3,4,5,6-tetrahydropyridines and 2-amino-5-(alkoxycarbonyl)-1,4,5,6-tetrahydropyrimidines as M1 muscarinic receptor agonists. |
University of Toledo |
8027978 |
50 |
Novel (4-phenylpiperidinyl)- and (4-phenylpiperazinyl)alkyl-spaced esters of 1-phenylcyclopentanecarboxylic acids as potent sigma-selective compounds. |
Albany Molecular Research |
8464039 |
12 |
Synthesis and biodistribution of iodine-125-labeled 1-azabicyclo[2.2.2]oct-3-yl alpha-hydroxy-alpha-(1-iodo-1-propen-3-yl)-alpha-phenylacetate. A new ligand for the potential imaging of muscarinic receptors by single photon emission computed tomography. |
Oak Ridge National Laboratory |
8246221 |
90 |
The synthesis and biochemical pharmacology of enantiomerically pure methylated oxotremorine derivatives. |
Medical Research Division of American Cyanamid |
8394936 |
11 |
Design of potent non-peptide competitive antagonists of the human bradykinin B2 receptor. |
Sterling Winthrop Pharmaceutical Research Division |
8360873 |
25 |
Synthesis and structure-activity studies of a series of spirooxazolidine-2,4-diones: 4-oxa analogues of the muscarinic agonist 2-ethyl-8-methyl-2,8-diazaspiro[4.5]decane-1,3-dione. |
Institute For Drug Discovery Research |
1319493 |
31 |
Synthesis and receptor binding properties of fluoro- and iodo-substituted high affinity sigma receptor ligands: identification of potential PET and SPECT sigma receptor imaging agents. |
National Institute of Diabetes and Digestive and Kidney Diseases |
1956033 |
121 |
Synthesis, molecular modeling studies, and muscarinic receptor activity of azaprophen analogues. |
Research Triangle Institute |
1920350 |
22 |
Muscarinic receptor binding profile of para-substituted caramiphen analogues. |
Virginia Commonwealth University |
2374141 |
33 |
Synthesis and biological evaluation of new antimuscarinic compounds with amidine basic centers. A useful bioisosteric replacement of classical cationic heads. |
Istituto De Angeli |
2573732 |
84 |
Synthesis and pharmacological evaluation of a series of 4-piperazinylpyrazolo[3,4-b]- and -[4,3-b][1,5]benzodiazepines as potential anxiolytics. |
Eli Lilly |
2571731 |
33 |
Synthesis and pharmacological evaluation of CNS activities of [1,2,3]triazolo[4,5-b][1,5]-, imidazolo[4,5-b][1,5]-, and pyrido[2,3-b][1,5]benzodiazepines. 10-Piperazinyl-4H-1,2,3-triazolo[4,5-b][1,5]benzodiazepines with neuroleptic activity. |
Eli Lilly |
3385735 |
32 |
Affinity and selectivity of the optical isomers of 3-quinuclidinyl benzilate and related muscarinic antagonists. |
Nova Pharmaceutical |
3385727 |
48 |
Heterocyclic muscarinic agonists. Synthesis and biological activity of some bicyclic sulfonium arecoline bioisosteres. |
Royal Danish School of Pharmacy |
3039136 |
328 |
Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships. |
TBA |
2869146 |
72 |
Synthesis and biological evaluation of 1-(1,2-benzisothiazol-3-yl)- and (1,2-benzisoxazol-3-yl)piperazine derivatives as potential antipsychotic agents. |
TBA |
6134835 |
76 |
Synthesis and receptor binding studies relevant to the neuroleptic activities of some 1-methyl-4-piperidylidene-9-substituted-pyrrolo[2,1-b][3]benzazepine derivatives. |
TBA |
15149693 |
56 |
The effect of 6-substituted-4',4"-difluorobenztropines on monoamine transporters and the muscarinic M1 receptor. |
National Institute On Drug Abuse-Intramural Research Program |
10450949 |
24 |
Discovery of a highly potent, functionally-selective muscarinic M1 agonist, WAY-132983 using rational drug design and receptor modelling. |
Wyeth-Ayerst Research |
9873644 |
74 |
Identification of side chains on 1,2,5-thiadiazole-azacycles optimal for muscarinic m1 receptor activation. |
Novo Nordisk |
| 28 |
Design of dual acting anticonvulsant-antimuscarinic succinimide and hydantoin derivatives |
TBA |
| 40 |
Structure activity relationships of non-peptide bradykinin B2 receptor antagonists |
TBA |
| 59 |
Muscarinic agonist SAR of azaspirodioxolanes |
TBA |
14695828 |
107 |
Pyrrolo[1,3]benzothiazepine-based serotonin and dopamine receptor antagonists. Molecular modeling, further structure-activity relationship studies, and identification of novel atypical antipsychotic agents. |
Universit£ |
22197142 |
42 |
Development of a more highly selective M(1) antagonist from the continued optimization of the MLPCN Probe ML012. |
Vanderbilt University Medical Center |
21930376 |
92 |
Development of a highly selective, orally bioavailable and CNS penetrant M1 agonist derived from the MLPCN probe ML071. |
Vanderbilt University Medical Center |
21194936 |
39 |
Discovery and optimization of a novel, selective and brain penetrant M1 positive allosteric modulator (PAM): the development of ML169, an MLPCN probe. |
Vanderbilt Institute of Chemical Biology/Chemical Synthesis Core |
19595599 |
14 |
Muscarinic receptor 1 agonist activity of novel N-aryl carboxamide substituted 3-morpholino arecoline derivatives in Alzheimer's presenile dementia models. |
University of Mysore |
20202841 |
47 |
Synthesis and SAR of N-(4-(4-alklylpiperazin-1-yl)phenyl)benzamides as muscarinic acetylcholine receptor subtype 1 (M1) anatgonists. |
Vanderbilt University Medical Center |
20004578 |
28 |
Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM. |
Vanderbilt University Medical Center |
19717214 |
28 |
Synthesis and pharmacological evaluation of novel N-alkyl/aryl substituted thiazolidinone arecoline analogues as muscarinic receptor 1 agonist in Alzheimer's dementia models. |
University of Mysore |
| 20 |
Synthesis and binding affinity of new muscarinic ligands structurally related to oxotremorine |
TBA |
| 16 |
Identification of novel (isoxazole)methylene-1-azabicyclic compounds with high affinity for the central nicotinic cholinergic receptor |
TBA |
| 28 |
Acylhydrazones as M1/M3 selective muscarinic agonists |
TBA |
| 8 |
Synthesis and biological activity of enantiomers of a conformationally restricted muscarone analog |
TBA |
| 32 |
Synthesis and structure activity relationships of alkyl substituted analogues of the functional M1 selective muscarinic receptor agonist xanomeline |
TBA |
| 3 |
Muscarinic receptor probes based on amine congeners of pirenzepine and telenzepine |
TBA |
| 45 |
SR 46559 A and related aminopyridazines are potent muscarinic agonists with no cholinergic syndrome |
TBA |
| 88 |
A rationale for the design and synthesis of m1 selective muscarinic agonists. |
TBA |
| 21 |
Synthesis and structure-activity relationships of heterocyclic analogues of the functional M1 selective muscarinic agonist hexyloxy-TZTP |
TBA |
| 40 |
Cholinergic agents: aldehyde, ketone, and oxime analogues of the muscarinic agonist UH5 |
TBA |
| 14 |
Cholinergic agents: 2-oxazolidinone analogues of the acetylcholine-receptor muscarinic agonist pilocarpine |
TBA |
19438238 |
45 |
Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins. |
Vanderbilt University Medical Center |
18640043 |
20 |
Muscarinic receptor 1 agonist activity of novel N-arylthioureas substituted 3-morpholino arecoline derivatives in Alzheimer's presenile dementia models. |
University of Mysore |
18359231 |
18 |
Effect of novel N-aryl sulfonamide substituted 3-morpholino arecoline derivatives as muscarinic receptor 1 agonists in Alzheimer's dementia models. |
University of Mysore |
12729659 |
29 |
4-(3,4-dihydro-1H-isoquinolin-2yl)-pyridines and 4-(3,4-dihydro-1H-isoquinolin-2-yl)-quinolines as potent NR1/2B subtype selective NMDA receptor antagonists. |
F. Hoffmann-La Roche |
11965364 |
36 |
Enantioselective synthesis of S-(+)-2beta-carboalkoxy-3alpha-[bis(4-fluorophenyl)methoxy]tropanes as novel probes for the dopamine transporter. |
National Institute On Drug Abuse-Intramural Research Program |
11934576 |
85 |
Synthesis and pharmacological evaluation of 6-piperidino- and 6-piperazinoalkyl-2(3H)-benzothiazolones as mixed sigma/5-HT(1A) ligands. |
Université |
32202101 |
120 |
Regiospecific Introduction of Halogens on the 2-Aminobiphenyl Subunit Leading to Highly Potent and Selective M3 Muscarinic Acetylcholine Receptor Antagonists and Weak Inverse Agonists. |
Friedrich-Alexander-Universit£T Erlangen-N£Rnberg |
10636243 |
6 |
Synthesis and binding studies of some epibatidine analogues. |
Institute of Pharmacy and Biochemistry |
10571170 |
27 |
Quinolizidinyl derivatives of 5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one as ligands for muscarinic receptors. |
Dipartimento Di Scienze Farmaceutiche - Università |
31492518 |
40 |
Discovery of novel steroidal histamine H |
Chemical Works of Gedeon Richter |
9464368 |
78 |
1,2,5-Thiadiazole analogues of aceclidine as potent m1 muscarinic agonists. |
Eli Lilly |
9435902 |
60 |
Novel N-substituted 3 alpha-[bis(4'-fluorophenyl)methoxy]tropane analogues: selective ligands for the dopamine transporter. |
National Institute On Drug Abuse |
30827105 |
23 |
Fluorination of Photoswitchable Muscarinic Agonists Tunes Receptor Pharmacology and Photochromic Properties. |
Julius Maximilian University of W£Rzburg |
8709107 |
99 |
Dopamine D3 and D4 receptor antagonists: synthesis and structure--activity relationships of (S)-(+)-N-(1-Benzyl-3-pyrrolidinyl)-5-chloro-4- [(cyclopropylcarbonyl) amino]-2-methoxybenzamide (YM-43611) and related compounds. |
Yamanouchi Pharmaceutical |
8558530 |
4 |
Substituted (pyrroloamino)pyridines: potential agents for the treatment of Alzheimer's disease. |
Hoechst-Roussel Pharmaceuticals |
8558529 |
195 |
Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeutic agents for Alzheimer's disease. |
Hoechst-Roussel Pharmaceuticals |
8410999 |
81 |
3,4-Dimethyl-4-(3-hydroxyphenyl)piperidines: opioid antagonists with potent anorectant activity. |
Eli Lilly |
8355251 |
8 |
Synthesis and binding properties of MK-801 isothiocyanates; (+)-3-isothiocyanato-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten- 5,10-imine hydrochloride: a new, potent and selective electrophilic affinity ligand for the NMDA receptor-coupled phencyclidine binding site. |
National Institute of Diabetes and Digestive and Kidney Diseases |
8246239 |
84 |
Development of high-affinity 5-HT3 receptor antagonists. Structure-affinity relationships of novel 1,7-annelated indole derivatives. |
Solvay Duphar |
8101877 |
80 |
New pyridobenzodiazepine derivatives as potential antipsychotics: synthesis and neurochemical study. |
University of LièGe |
23792350 |
53 |
Synthesis and pharmacological evaluation of new N-phenylpiperazine derivatives designed as homologues of the antipsychotic lead compound LASSBio-579. |
Universidade Federal Do Rio De Janeiro |
7990109 |
62 |
Bioisosteres of arecoline: 1,2,3,6-tetrahydro-5-pyridyl-substituted and 3-piperidyl-substituted derivatives of tetrazoles and 1,2,3-triazoles. Synthesis and muscarinic activity. |
H. Lundbeck |
23352509 |
27 |
Pharmacological properties and predicted binding mode of arylmethylene quinuclidine-like derivatives at the ?3?4 nicotinic acetylcholine receptor (nAChR). |
Targacept |
11087580 |
31 |
Synthesis, (18)F-labeling, and biological evaluation of piperidyl and pyrrolidyl benzilates as in vivo ligands for muscarinic acetylcholine receptors. |
University of Michigan Medical School |
10585207 |
31 |
Improving the nicotinic pharmacophore with a series of (Isoxazole)methylene-1-azacyclic compounds: synthesis, structure-activity relationship, and molecular modeling. |
Novo Nordisk |
9784090 |
11 |
Synthesis and modeling studies of a potent conformationally rigid muscarinic agonist: 1-azabicyclo[2.2.1]heptanespirofuranone. |
Astra Arcus Usa |
9703467 |
84 |
Synthesis and pharmacological characterization of O-alkynyloximes of tropinone and N-methylpiperidinone as muscarinic agonists. |
National University of Singapore |
9046345 |
20 |
Muscarinic analgesics with potent and selective effects on the gastrointestinal tract: potential application for the treatment of irritable bowel syndrome. |
Lilly Research Laboratories |
7739014 |
23 |
In vitro muscarinic activity of spiromuscarones and related analogs. |
Fisons Pharmaceuticals |
8201606 |
2 |
Presynaptic cholinergic modulators as potent cognition enhancers and analgesic drugs. 2. 2-Phenoxy-, 2-(phenylthio)-, and 2-(phenylamino)alkanoic acid esters. |
Universit£ |
8201605 |
3 |
Presynaptic cholinergic modulators as potent cognition enhancers and analgesic drugs. 1. Tropic and 2-phenylpropionic acid esters. |
Universit£ |
8464038 |
14 |
Design, synthesis, and neurochemical evaluation of 5-(3-alkyl-1,2,4- oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidines as M1 muscarinic receptor agonists. |
University of Toledo |
3746815 |
15 |
In vitro labeling of serotonin-S2 receptors: synthesis and binding characteristics of [3H]-7-aminoketanserin. |
TBA |
3712371 |
49 |
A novel class of conformationally restricted heterocyclic muscarinic agonists. |
TBA |
30258541 |
94 |
VU6007477, a Novel M |
Vanderbilt Univercity |
3373484 |
36 |
Tricyclic compounds as selective antimuscarinics. 2. Structure-activity relationships of M1-selective antimuscarinics related to pirenzepine. |
Dr. Karl Thomae |
29652494 |
18 |
Ligand-Phospholipid Conjugation: A Versatile Strategy for Developing Long-Acting Ligands That Bind to Membrane Proteins by Restricting the Subcellular Localization of the Ligand. |
University of Shizuoka |
2892936 |
21 |
Synthesis and potential antipsychotic activity of 1H-imidazo[1,2-c]pyrazolo[3,4-e]pyrimidines. |
Warner-Lambert |
29146472 |
71 |
Discovery of the first low-shift positive allosteric modulators for the muscarinic M1 receptor. |
Roche Pharma Research and Early Development |
2875184 |
57 |
(5-Amino-1,3-dimethyl-1H-pyrazol-4-yl)(2-fluorophenyl)methanones . A series of novel potential antipsychotic agents. |
TBA |
2571728 |
21 |
Sterically hindered 5,11-dicarbo analogues of clozapine as potential chiral antipsychotic agents. |
Vanderbilt University |
29754948 |
69 |
The discovery of VU0486846: steep SAR from a series of M |
Vanderbilt University Medical Center |
2066986 |
137 |
Functionalized congener approach to muscarinic antagonists: analogues of pirenzepine. |
Niddk |
28633897 |
73 |
Discovery and optimization of 3-(4-aryl/heteroarylsulfonyl)piperazin-1-yl)-6-(piperidin-1-yl)pyridazines as novel, CNS penetrant pan-muscarinic antagonists. |
Vanderbilt University School of Medicine |
1967652 |
27 |
Chloro-substituted, sterically hindered 5,11-dicarbo analogues of clozapine as potential chiral antipsychotic agents. |
Vanderbilt University |
1732522 |
42 |
Muscarinic activity of the thiolactone, lactam, lactol, and thiolactol analogues of pilocarpine and a hypothetical model for the binding of agonists to the m1 receptor. |
Sandoz Pharma |
1613751 |
68 |
Novel functional M1 selective muscarinic agonists. Synthesis and structure-activity relationships of 3-(1,2,5-thiadiazolyl)-1,2,5,6-tetrahydro-1-methylpyridines . |
Novo Nordisk Cns Division |
1613746 |
48 |
Synthesis and muscarinic receptor activity of ester derivatives of 2-substituted 2-azabicyclo[2.2.1]heptan-5-ol and -6-ol. |
Research Triangle Institute |
1588567 |
18 |
Synthesis and pharmacological investigation of the enantiomers of muscarone and allomuscarone. |
Istituto Chimico-Farmaceutico Dell'Università |
1578480 |
26 |
Synthesis and in vitro characterization of novel amino terminally modified oxotremorine derivatives for brain muscarinic receptors. |
Abbott Laboratories |
1548680 |
12 |
Synthesis and in vitro biological profile of all four isomers of the potent muscarinic agonist 3-(3-methyl-1,2,4-oxadiazol-5-yl)-1-azabicyclo[2.2.1]heptane. |
Merck Sharp and Dohme Research Laboratories |
28442253 |
68 |
Optimization of M |
Vanderbilt University Medical Center |
1507212 |
42 |
Urea and 2-imidazolidone derivatives of the muscarinic agents oxotremorine and N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide. |
University of Uppsala |
1433209 |
58 |
Novel functional M1 selective muscarinic agonists. 2. Synthesis and structure-activity relationships of 3-pyrazinyl-1,2,5,6-tetrahydro-1-methylpyridines. Construction of a molecular model for the M1 pharmacophore. |
Eli Lilly |
23548908 |
1 |
Inhibition of isoleucyl-tRNA synthetase as a potential treatment for human African Trypanosomiasis. |
University of Washington |
26051755 |
2 |
New monomeric and dimeric uridinyl derivatives as inhibitors of chitin synthase. |
Silesian University of Technology |
10956187 |
18 |
Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles. |
University of Newcastle |