205 articles for thisTarget

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The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
27676089	35	A Cyclic Tetrapeptide ("Cyclodal") and Its Mirror-Image Isomer Are Both High-Affinityµ Opioid Receptor Antagonists.	Clinical Research Institute of Montreal
27301366	30	[Dmt(1)]DALDA analogues modified with tyrosine analogues at position 1.	Nanjing Medical University
27035422	46	Bifunctional Peptide-Based Opioid Agonist-Nociceptin Antagonist Ligands for Dual Treatment of Acute and Neuropathic Pain.	Vrije Universiteit Brussel
27234885	31	Evaluation of N-substituent structural variations in opioid receptor profile of LP1.	University of Catania
26713106	59	Dual Alleviation of Acute and Neuropathic Pain by Fused Opioid Agonist-Neurokinin 1 Antagonist Peptidomimetics.	Vrije Universiteit Brussel
26656913	85	Multitarget opioid ligands in pain relief: New players in an old game.	University of Catania
26712115	36	Design synthesis and structure-activity relationship of 5-substituted (tetrahydronaphthalen-2yl)methyl with N-phenyl-N-(piperidin-2-yl)propionamide derivatives as opioid ligands.	University of Arizona
26330078	51	Synthesis and biological evaluation of 2-alkyl-2-methoxymethyl-salvinorin ethers as selective¿-opioid receptor agonists.	Harvard Medical School
26323872	49	Design and synthesis of novel bivalent ligands (MOR and DOR) by conjugation of enkephalin analogues with 4-anilidopiperidine derivatives.	University of Arizona
26299827	43	Discovery of 5-substituted tetrahydronaphthalen-2yl-methyl with N-phenyl-N-(piperidin-4-yl)propionamide derivatives as potent opioid receptor ligands.	University of Arizona
26346669	53	Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 5, novel pentacyclic propellane derivatives with a 6-amide side chain.	University of Tsukuba
26252963	15	Novel diazabicycloalkane delta opioid agonists.	Istituto Di Farmacologia Traslazionale
25283554	43	Design, synthesis, and structure-activity relationship of novel opioid¿ receptor selective agonists:a-iminoamide derivatives with an azabicyclo[2.2.2]octene skeleton.	Kitasato University
25147605	52	Synthesis and Pharmacology of a Novel¿ Opioid Receptor (KOR) Agonist with a 1,3,5-Trioxazatriquinane Skeleton.	Kitasato University
25129170	20	'Carba'-carfentanil (trans isomer): aµ opioid receptor (MOR) partial agonist with a distinct binding mode.	Clinical Research Institute of Montreal
25544687	60	Synthesis and biological evaluation of compact, conformationally constrained bifunctional opioid agonist - neurokinin-1 antagonist peptidomimetics.	Vrije Universiteit Brussel
25783191	87	Design, syntheses, and pharmacological characterization of 17-cyclopropylmethyl-3,14ß-dihydroxy-4,5a-epoxy-6a-(isoquinoline-3'-carboxamido)morphinan analogues as opioid receptor ligands.	Virginia Commonwealth University
25562563	18	Methoxyflavones from Stachys glutinosa with binding affinity to opioid receptors: in silico, in vitro, and in vivo studies.	National Research Council
25248680	67	Synthesis of a novel universal opioid receptor agonist with the 1,3,5-trioxazatriquinane skeleton and its pharmacologies.	Kitasato University
25221662	24	Novel cyclic biphalin analogue with improved antinociceptive properties.	Universit£
24900842	71	Novel delta opioid receptor agonists with oxazatricyclodecane structure.	Kitasato University
24839540	26	In Vitro Membrane Permeation Studies and in Vivo Antinociception of Glycosylated Dmt	Vrije Universiteit Brussel
24613457	64	Endomorphin analogues with mixedµ-opioid (MOP) receptor agonism/d-opioid (DOP) receptor antagonism and lackingß-arrestin2 recruitment activity.	Nanjing Medical University
24602401	40	[Dmt(1)]DALDA analogues with enhancedµ opioid agonist potency and with a mixedµ/¿ opioid activity profile.	Nanjing Medical University
23547584	19	Biological active analogues of the opioid peptide biphalin: mixeda/ß(3)-peptides.	Universit£
23360448	18	Development of¿ opioid receptor antagonists.	Research Triangle Institute
23200250	36	The effect of 17-N substituents on the activity of the opioid¿ receptor in nalfurafine derivatives.	Kitasato University
16290934	51	Highly potent and selective zwitterionic agonists of the delta-opioid receptor. Part 1.	Pfizer
7154003	7	A quantitative structure-activity relationship study of the inhibitory action of a series of enkephalin-like peptides in the guinea pig ileum and mouse vas deferens bioassays.	TBA
11133082	32	Assessment of substitution in the second pharmacophore of Dmt-Tic analogues.	University of Naples
23131341	50	Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. 3: synthesis of novel triplet drugs with the bis(epoxymethano) or bis(dimethylepoxymethano) structure (double-capped triplet).	Kitasato University
23116891	15	Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: part 3, novel propellane derivatives with pentacyclic skeletons.	Kitasato University
23103094	39	Essential structure of opioid¿ receptor agonist nalfurafine for binding to the¿ receptor 3: synthesis of decahydro(iminoethano)phenanthrene derivatives with an oxygen functionality at the 3-position and their pharmacologies.	Kitasato University
22325949	28	Novel TIPP (H-Tyr-Tic-Phe-Phe-OH) analogues displaying a wide range of efficacies at thed opioid receptor. Discovery of two highly potent and selectived opioid agonists.	Clinical Research Institute of Montreal
23102273	60	Variation of the net charge, lipophilicity, and side chain flexibility in Dmt(1)-DALDA: Effect on Opioid Activity and Biodistribution.	Vrije Universiteit Brussel
22966938	20	cis-4-amino-L-proline residue as a scaffold for the synthesis of cyclic and linear endomorphin-2 analogues: part 2.	Universit£
22734622	78	Synthesis and evaluation of aryl-naloxamide opiate analgesics targeting truncated exon 11-associatedµ opioid receptor (MOR-1) splice variants.	Memorial Sloan-Kettering Cancer Center
22724433	76	A new class of highly potent and selective endomorphin-1 analogues containinga-methylene-ß-aminopropanoic acids (map).	Lanzhou University
23585918	16	Tuned-Affinity Bivalent Ligands for the Characterization of Opioid Receptor Heteromers.	TBA
22967810	102	Synthesis of quinolinomorphinan derivatives as highly selectived opioid receptor ligands.	Kitasato University
22742909	24	Essential structure of opioid¿ receptor agonist nalfurafine for binding to the¿ receptor 2: synthesis of decahydro(iminoethano)phenanthrene derivatives and their pharmacologies.	Kitasato University
22445285	26	Design and synthesis of novel opioid ligands with an azabicyclo[2.2.2]octane skeleton and their pharmacologies.	Kitasato University
21128594	93	Development of potent µ and d opioid agonists with high lipophilicity.	University of Arizona
20547453	122	Design and synthesis of trivalent ligands targeting opioid, cholecystokinin, and melanocortin receptors for the treatment of pain.	University of Arizona
20218625	27	"Carba"-analogues of fentanyl are opioid receptor agonists.	Clinical Research Institute of Montreal
20560643	71	Improving metabolic stability by glycosylation: bifunctional peptide derivatives that are opioid receptor agonists and neurokinin 1 receptor antagonists.	University of Arizona
19211245	27	Synthesis and biological evaluation of C-12 triazole and oxadiazole analogs of salvinorin A.	Harvard Medical School
18990576	11	Synthesis of a novel 6,14-epoxymorphinan derivative and its pharmacology.	Kitasato University
18337104	7	Syntheses of 4,6'-epoxymorphinan derivatives and their pharmacologies.	Kitasato University
18370374	12	Blood-brain barrier penetration by two dermorphin tetrapeptide analogues: role of lipophilicity vs structural flexibility.	Vrije Universiteit Brussel
18311909	10	Synthesis of a potent and selective (18)F-labeled delta-opioid receptor antagonist derived from the Dmt-Tic pharmacophore for positron emission tomography imaging.	Stanford University School of Medicine
18178091	24	Role of benzimidazole (Bid) in the delta-opioid agonist pseudopeptide H-Dmt-Tic-NH-CH(2)-Bid (UFP-502).	University of Ferrara
18166466	12	Novel coumarin glycoside and phenethyl vanillate from Notopterygium forbesii and their binding affinities for opioid and dopamine receptors.	Harvard Medical School
17981041	79	Standard protecting groups create potent and selective kappa opioids: salvinorin B alkoxymethyl ethers.	Mclean Hospital
18293909	5	Toward a structure-based model of salvinorin A recognition of the kappa-opioid receptor.	University of Minnesota
17402725	9	Indium-labeled macrocyclic conjugates of naltrindole: high-affinity radioligands for in vivo studies of peripheral delta opioid receptors.	University of Missouri-Columbia
16942034	19	Effect of lysine at C-terminus of the Dmt-Tic opioid pharmacophore.	University of Cagliari
16789756	25	New 2',6'-dimethyl-L-tyrosine (Dmt) opioid peptidomimetics based on the Aba-Gly scaffold. Development of unique mu-opioid receptor ligands.	Vrije Universiteit Brussels
16509592	101	Design and synthesis of novel hydrazide-linked bifunctional peptides as delta/mu opioid receptor agonists and CCK-1/CCK-2 receptor antagonists.	University of Arizona
15857143	48	Synthesis and biological evaluation of 14-alkoxymorphinans. 22.(1) Influence of the 14-alkoxy group and the substitution in position 5 in 14-alkoxymorphinan-6-ones on in vitro and in vivo activities.	Sapienza University of Rome
15863299	8	Synthesis and biological evaluation of new biphalin analogues with non-hydrazine linkers.	University of Arizona
14998329	142	Identification of opioid ligands possessing mixed micro agonist/delta antagonist activity among pyridomorphinans derived from naloxone, oxymorphone, and hydromorphone [correction of hydropmorphone].	Southern Research Institute
13678399	54	Peptide science: exploring the use of chemical principles and interdisciplinary collaboration for understanding life processes.	University of Arizona
12459023	46	Potent delta-opioid receptor agonists containing the Dmt-Tic pharmacophore.	University of Cagliari
11311071	53	Effect of N-alkyl and N-alkenyl substituents in noroxymorphindole, 17-substituted-6,7-dehydro-4,5alpha-epoxy-3,14-dihydroxy-6,7:2',3'-indolomorphinans, on opioid receptor affinity, selectivity, and efficacy.	National Institute of Diabetes and Digestive and Kidney Diseases
11300867	32	Investigation of the selectivity of oxymorphone- and naltrexone-derived ligands via site-directed mutagenesis of opioid receptors: exploring the"address" recognition locus.	University of Minnesota
11543672	24	[2',6'-Dimethyltyrosine]dynorphin A(1-11)-NH2 analogues lacking an N-terminal amino group: potent and selective kappa opioid antagonists.	Clinical Research Institute of Montreal
11405645	13	Transformation of a kappa-opioid receptor antagonist to a kappa-agonist by transfer of a guanidinium group from the 5'- to 6'-position of naltrindole.	University of Minnesota
11052799	10	Synthesis and evaluation of N,N-dialkyl enkephalin-based affinity labels for delta opioid receptors.	University of Maryland
10639287	62	Probes for narcotic receptor mediated phenomena. 26. Synthesis and biological evaluation of diarylmethylpiperazines and diarylmethylpiperidines as novel, nonpeptidic delta opioid receptor ligands.	National Institute of Diabetes and Digestive and Kidney Diseases
10479286	53	Synthesis, opioid receptor binding, and biological activities of naltrexone-derived pyrido- and pyrimidomorphinans.	Southern Research Institute
9667975	86	Synthesis, opioid receptor binding, and bioassay of naltrindole analogues substituted in the indolic benzene moiety.	Southern Research Institute
9057856	53	Probes for narcotic receptor mediated phenomena. 23. Synthesis, opioid receptor binding, and bioassay of the highly selective delta agonist (+)-4-[(alpha R)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]- N,N-diethylbenzamide (SNC 80) and related novel nonpeptide delta opioid r	National Institute of Diabetes and Digestive and Kidney Diseases
9397176	28	Cyclic enkephalin analogues with exceptional potency and selectivity for delta-opioid receptors.	University of Arizona
9379438	31	Discovery of a novel class of substituted pyrrolooctahydroisoquinolines as potent and selective delta opioid agonists, based on an extension of the message-address concept.	Smithkline Beecham
9301674	60	Evolution of the Dmt-Tic pharmacophore: N-terminal methylated derivatives with extraordinary delta opioid antagonist activity.	University of Ferrara
9207938	15	Pyrrolomorphinans as delta opioid receptor antagonists. The role of steric hindrance in conferring selectivity.	University of Minnesota
9171881	17	7-Spiroindanyl derivatives of naltrexone and oxymorphone as selective ligands for delta opioid receptors.	University of Minnesota
8642567	64	Probes for narcotic receptor-mediated phenomena. 21. Novel derivatives of 3-(1,2,3,4,5,11-hexahydro-3-methyl-2,6-methano-6H-azocino[4,5-b]indol- 6-yl)-phenols with improved delta opioid receptor selectivity.	National Institute of Diabetes and Digestive and Kidney Diseases
7739011	90	Probes for narcotic receptor-mediated phenomena. 20. Alteration of opioid receptor subtype selectivity of the 5-(3-hydroxyphenyl)morphans by application of the message-address concept: preparation of delta-opioid receptor ligands.	National Institute of Diabetes and Digestive and Kidney Diseases
8035418	30	Probes for narcotic receptor mediated phenomena. 19. Synthesis of (+)-4-[(alpha R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3- methoxybenzyl]-N,N-diethylbenzamide (SNC 80): a highly selective, nonpeptide delta opioid receptor agonist.	National Institute of Diabetes and Digestive and Kidney Diseases
8021929	13	Synthesis and delta-opioid receptor antagonist activity of a naltrindole analogue with a regioisomeric indole moiety.	University of Minnesota
8021915	16	Newly discovered stereochemical requirements in the side-chain conformation of delta opioid agonists for recognizing opioid delta receptors.	University of Arizona
8201592	27	[L-Ala3]DPDPE: a new enkephalin analog with a unique opioid receptor activity profile. Further evidence of delta-opioid receptor multiplicity.	University of Arizona
8289188	30	Cyclic enkephalin analogs with exceptional potency at peripheral delta opioid receptors.	University of Arizona
8360887	9	Synthesis and kappa-opioid antagonist selectivity of a norbinaltorphimine congener. Identification of the address moiety required for kappa-antagonist activity.	University of Minnesota
1648137	30	Topographically designed analogues of [D-Pen,D-Pen5]enkephalin.	University of Arizona
1851843	96	Synthesis and structure-activity relationships of deltorphin analogues.	University of Ferrara
2832604	3	Binaltorphimine-related bivalent ligands and their kappa opioid receptor antagonist selectivity.	University of Minnesota
6296388	68	Synthesis and pharmacological characterization in vitro of cyclic enkephalin analogues: effect of conformational constraints on opiate receptor selectivity.	TBA
6276540	20	Evidence of the preferential involvement of mu receptors in analgesia using enkephalins highly selective for peripheral mu or delta receptors.	TBA
15115401	24	Oral bioavailability of a new class of micro-opioid receptor agonists containing 3,6-bis[Dmt-NH(CH(2))(n)]-2(1H)-pyrazinone with central-mediated analgesia.	National Institutes of Environmental Health Sciences
11755357	14	Synthesis and biological activities of YkFA analogues: effects of position 4 substitutions and altered ring size on in vitro opioid activity.	University of Louisville
10612597	31	Optically pure (-)-4-[(N-allyl-3-methyl-4-piperidinyl)phenyl-amino]-N,N-diethylbenzami de displays selective binding and full agonist activity for the delta opioid receptor.	Research Triangle Institute
10571174	25	(+/-)-4-[(N-allyl-cis-3-methyl-4-piperidinyl)phenylamino]-N,N-diethylbenzamide displays selective binding for the delta opioid receptor.	Research Triangle Institute
	36	Pyrrolooctahydroisoquinolines as potent and selective opioid receptor ligands: SAR analysis and docking studies	TBA
22197670	51	Synthesis of quinolinomorphinan-4-ol derivatives asd opioid receptor agonists.	Kitasato University
21925887	10	Synthesis and biological evaluation of new opioid agonist and neurokinin-1 antagonist bivalent ligands.	University of Arizona
21889335	27	Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. Part 2: Synthesis of novel triplet drugs with the epoxymethano structure (capped homotriplet).	Kitasato University
21413804	21	Design of novel neurokinin 1 receptor antagonists based on conformationally constrained aromatic amino acids and discovery of a potent chimeric opioid agonist-neurokinin 1 receptor antagonist.	Vrije Universiteit Brussel
21366266	66	Discovery of a potent and efficacious peptide derivative ford/µ opioid agonist/neurokinin 1 antagonist activity with a 2',6'-dimethyl-L-tyrosine: in vitro, in vivo, and NMR-based structural studies.	University of Arizona
20850307	27	Design and synthesis of KNT-127, ad-opioid receptor agonist effective by systemic administration.	Kitasato University
20692738	34	Synthesis and activity of endomorphin-2 and morphiceptin analogues with proline surrogates in position 2.	Sapienza University of Rome
20637637	46	Role of 2',6'-dimethyl-l-tyrosine (Dmt) in some opioid lead compounds.	University of Cagliari
20617791	70	Biological and conformational evaluation of bifunctional compounds for opioid receptor agonists and neurokinin 1 receptor antagonists possessing two penicillamines.	University of Arizona
20476738	14	Synthesis and evaluation of new endomorphin-2 analogues containing (Z)-alpha,beta-didehydrophenylalanine (Delta(Z)Phe) residues.	Universit£
20137938	28	Novel multiple opioid ligands based on 4-aminobenzazepinone (Aba), azepinoindole (Aia) and tetrahydroisoquinoline (Tic) scaffolds.	Vrije Universiteit Brussel
19762245	69	The biological activity and metabolic stability of peptidic bifunctional compounds that are opioid receptor agonists and neurokinin-1 receptor antagonists with a cystine moiety.	University of Arizona
19646882	72	Novel delta opioid receptor agonists exhibit differential stimulation of signaling pathways.	University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School and The Informatics Institute of Umdnj
19540763	4	Synthesis and investigations of double-pharmacophore ligands for treatment of chronic and neuropathic pain.	University of Arizona
19827750	39	Agonist vs antagonist behavior of delta opioid peptides containing novel phenylalanine analogues in place of Tyr(1).	Clinical Research Institute of Montreal
19807094	45	The effects of C-terminal modifications on the opioid activity of [N-benzylTyr(1)]dynorphin A-(1-11) analogues.	University of Kansas
19715279	20	Design, synthesis, and pharmacological activities of dynorphin A analogues cyclized by ring-closing metathesis.	The University of Kansas
19642675	60	Influence of the side chain next to C-terminal benzimidazole in opioid pseudopeptides containing the Dmt-Tic pharmacophore.	University of Cagliari
19560919	28	Synthesis and evaluation of new endomorphin analogues modified at the Pro(2) residue.	Universit£
	12	The stereochemical requirements of the novel δ-opioid selective dipeptide antagonist TMT-Tic	TBA
	8	Topographical requirements for delta opioid ligands: The synthesis and biological properties of a cyclic analogue of deltorphin I	TBA
19147366	60	Modification of the furan ring of salvinorin A: identification of a selective partial agonist at the kappa opioid receptor.	Mclean Hospital
19062273	41	Conformationally constrained opioid ligands: the Dmt-Aba and Dmt-Aia versus Dmt-Tic scaffold.	Vrije Universiteit Brussel
18821747	45	The importance of micelle-bound states for the bioactivities of bifunctional peptide derivatives for delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists.	University of Arizona
18800771	26	Novel opioid peptide derived antagonists containing (2S)-2-methyl-3-(2,6-dimethyl-4-carbamoylphenyl)propanoic acid [(2S)-Mdcp].	National University of Singapore
18701308	1	Design and synthesis of a metabolically stable and potent antitussive agent, a novel delta opioid receptor antagonist, TRK-851.	Toray Industries
18680274	44	Further studies on lead compounds containing the opioid pharmacophore Dmt-Tic.	University of Cagliari
18490168	32	Structure-activity study of endomorphin-2 analogs with C-terminal modifications by NMR spectroscopy and molecular modeling.	Lanzhou University
17826995	48	Design and synthesis of opioidmimetics containing 2',6'-dimethyl-L-tyrosine and a pyrazinone-ring platform.	Kobe Gakuin University
17497839	72	Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mixed mu-agonist/delta-antagonist and dual mu-agonist/delta-agonist opioid ligands.	Kobe Gakuin University
17350835	88	Further studies of tyrosine surrogates in opioid receptor peptide ligands.	Adolor
17315860	40	Dicarba analogues of the cyclic enkephalin peptides H-Tyr-c[D-Cys-Gly-Phe-D(or L)-Cys]NH(2) retain high opioid activity.	Clinical Research Institute of Montreal
17266203	29	Synthesis and characterization of potent and selective mu-opioid receptor antagonists, [Dmt(1), D-2-Nal(4)]endomorphin-1 (Antanal-1) and [Dmt(1), D-2-Nal(4)]endomorphin-2 (Antanal-2).	Medical University
17201419	93	Partial retro-inverso, retro, and inverso modifications of hydrazide linked bifunctional peptides for opioid and cholecystokinin (CCK) receptors.	University of Arizona
17188879	16	Endomorphin-1 analogs with enhanced metabolic stability and systemic analgesic activity: design, synthesis, and pharmacological characterization.	Lanzhou University
17142049	40	Transformation of mu-opioid receptor agonists into biologically potent mu-opioid receptor antagonists.	Kobe Gakuin University
16949282	12	Synthesis of 3,6-bis[H-Tyr/H-Dmt-NH(CH2)m,n]-2(1H)pyrazinone derivatives: function of alkyl chain length on opioid activity.	Kobe Gakuin University
16828552	20	Synthesis and evaluation of 3-aminopropionyl substituted fentanyl analogues for opioid activity.	University of Arizona
16759107	18	6-N,N-dimethylamino-2,3-naphthalimide: a new environment-sensitive fluorescent probe in delta- and mu-selective opioid peptides.	Universidad De Santiago De Compostela
16483774	66	Identification of potent phenyl imidazoles as opioid receptor agonists.	Johnson & Johnson Pharmaceutical Research & Development
16366592	33	Conversion of the potent delta-opioid agonist H-Dmt-Tic-NH-CH(2)-bid into delta-opioid antagonists by N(1)-benzimidazole alkylation(1).	University of Cagliari
16335927	48	Potent Dmt-Tic pharmacophoric delta- and mu-opioid receptor antagonists.	Kobe Gakuin University
16275086	18	Synthesis and biological activity of the first cyclic biphalin analogues.	University of Arizona
16183273	12	New series of potent delta-opioid antagonists containing the H-Dmt-Tic-NH-hexyl-NH-R motif.	Kobe Gakuin University
16107162	10	From the potent and selective mu opioid receptor agonist H-Dmt-d-Arg-Phe-Lys-NH(2) to the potent delta antagonist H-Dmt-Tic-Phe-Lys(Z)-OH.	University of Cagliari
15780619	15	Structure-activity relationship of the novel bivalent and C-terminal modified analogues of endomorphin-2.	Lanzhou University
15658871	28	Development of potent mu-opioid receptor ligands using unique tyrosine analogues of endomorphin-2.	Kobe Gakuin University
15324897	3	A novel cyclic enkephalin analogue with potent opioid antagonist activity.	Clinical Research Institute of Montreal
14711314	63	Synthesis and opioid activity of side-chain-to-side-chain cyclic dynorphin A-(1-11) amide analogues cyclized between positions 2 and 5. 1. Substitutions in position 3.	University of Maryland
12954053	39	Effects of the substitution of Phe4 in the opioid peptide [D-Ala8]dynorphin A-(1-11)NH2.	University of Maryland
12852751	34	Unique high-affinity synthetic mu-opioid receptor agonists with central- and systemic-mediated analgesia.	Kobe Gakuin University
12657261	32	Dermorphin tetrapeptide analogues with 2',6'-dimethylphenylalanine (Dmp) substituted for aromatic amino acids have high mu opioid receptor binding and biological activities.	Tohoku Pharmaceutical University
12408719	21	Synthesis and structure-activity relationships of an orally available and long-acting analgesic peptide, N(alpha)-amidino-Tyr-D-Arg-Phe-MebetaAla-OH (ADAMB).	Daiichi Fine Chemical
12190304	10	Solid phase synthesis and evaluation of Tyr-Tic-Phe-Phe(p-NHCOCH(2)Br) ([Phe(p-bromoacetamide)(4)]TIPP), a potent affinity label for delta opioid receptors.	University of Maryland
12166947	30	Synthesis and biological activities of cyclic lanthionine enkephalin analogues: delta-opioid receptor selective ligands.	University of California
11958984	24	Dermorphin and deltorphin heptapeptide analogues: replacement of Phe residue by Dmp greatly improves opioid receptor affinity and selectivity.	Tohoku Pharmaceutical University
11212102	24	Enkephalin analogues with 2',6'-dimethylphenylalanine replacing phenylalanine in position 4.	Tohoku Pharmaceutical University
11150176	9	Synthesis and evaluation of isothiocyanate-containing derivatives of the delta-opioid receptor antagonist Tyr-Tic-Phe-Phe (TIPP) as potential affinity labels for delta-opioid receptors.	University of Maryland
11150174	84	Synthesis and in vitro and in vivo activity of (-)-(1R,5R,9R)- and (+)-(1S,5S,9S)-N-alkenyl-, -N-alkynyl-, and -N-cyanoalkyl-5, 9-dimethyl-2'-hydroxy-6,7-benzomorphan homologues.	Virginia Commonwealth University
27556704	64	Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit ?-Arrestin-2.	Memorial Sloan Kettering Cancer Center
10753473	14	Deltorphin II analogues with 6-hydroxy-2-aminotetralin-2-carboxylic acid in position 1.	Hungarian Academy of Sciences
10617088	15	Synthesis and biological activities of position one and three transposed analogs of the opioid peptide YKFA.	University of Louisville
9986710	28	Dermorphin and deltorphin glycosylated analogues: synthesis and antinociceptive activity after systemic administration.	Sapienza University of Rome
9871617	24	Modifications of the 4,4'-residues and SAR studies of Biphalin, a highly potent opioid receptor active peptide.	University of Arizona
9822547	41	De novo design, synthesis, and biological activities of high-affinity and selective non-peptide agonists of the delta-opioid receptor.	The University of Arizona
30608693	48	Design, Synthesis, and Biological Evaluation of the Third Generation 17-Cyclopropylmethyl-3,14?-dihydroxy-4,5?-epoxy-6?-[(4'-pyridyl)carboxamido]morphinan (NAP) Derivatives as ?/? Opioid Receptor Dual Selective Ligands.	Virginia Commonwealth University
9301669	24	7-spirobenzocyclohexyl derivatives of naltrexone, oxymorphone, and hydromorphone as selective opioid receptor ligands.	University of Minnesota
9258365	28	Helix-inducing alpha-aminoisobutyric acid in opioid mimetic deltorphin C analogues.	National Institute of Environmental Health Sciences
31782922	107	Application of Bivalent Bioisostere Concept on Design and Discovery of Potent Opioid Receptor Modulators.	Virginia Commonwealth University
8691442	52	Effects of modifications of residues in position 3 of dynorphin A(1-11)-NH2 on kappa receptor selectivity and potency.	University of Arizona
26611918	45	Enkephalin analogues with N-phenyl-N-(piperidin-2-ylmethyl)propionamide derivatives: Synthesis and biological evaluations.	University of Arizona
8576920	34	Design and synthesis of 1-aminocycloalkane-1-carboxylic acid-substituted deltorphin analogues: unique delta and mu opioid activity in modified peptides.	University of Ferrara
26465170	87	Discovery of Novel Multifunctional Ligands with ?/? Opioid Agonist/Neurokinin-1 (NK1) Antagonist Activities for the Treatment of Pain.	University of Arizona
26212775	77	Discovery of tripeptide-derived multifunctional ligands possessing delta/mu opioid receptor agonist and neurokinin 1 receptor antagonist activities.	University of Arizona
8384662	20	A topochemical approach to explain morphiceptin bioactivity.	University of California
8289187	47	Design of cyclic deltorphins and dermenkephalins with a disulfide bridge leads to analogues with high selectivity for delta-opioid receptors.	University of Arizona
24262888	105	The most effective influence of 17-(3-ethoxypropyl) substituent on the binding affinity and the agonistic activity in KNT-127 derivatives, ? opioid receptor agonists.	Kitasato University
24095014	52	N-Alkyl dien- and trienamides from the roots of Otanthus maritimus with binding affinity for opioid and cannabinoid receptors.	Uos of Cagliari
8096246	70	Design and synthesis of highly potent and selective cyclic dynorphin A analogs. 2. New analogs.	University of Arizona
24103580	36	Novel 6?-acylaminomorphinans with analgesic activity.	Semmelweis University
24090913	42	Synthesis and biological evaluation of novel delta (?) opioid receptor ligands with diazatricyclodecane skeletons.	C.N.R. Istituto Di Farmacologia Traslazionale
23988352	9	Systematic replacement of amides by 1,4-disubstituted[1,2,3]triazoles in Leu-enkephalin and the impact on the delta opioid receptor activity.	Universit£
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