Compile Data Set for Download or QSAR

Found 521 hits with Last Name = 'demuth' and Initial = 'h'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glutaminyl-peptide cyclotransferase (Homo sapiens (Human))	BDBM259915 (US9512115, 19) Show SMILES Fc1c(F)c(ccc1[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1)N1CCC(F)(F)C1 |r| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	2.49	-49.9	n/a	n/a	n/a	n/a	n/a	6.0	30
PROBIODRUG AG US Patent					Assay Description All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...				US Patent US9512115 (2016) BindingDB Entry DOI: 10.7270/Q2XK8DG4
					More data for this Ligand-Target Pair
Glutaminyl-peptide cyclotransferase (Homo sapiens (Human))	BDBM259915 (US9512115, 19) Show SMILES Fc1c(F)c(ccc1[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1)N1CCC(F)(F)C1 |r| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	2.53	-49.9	n/a	n/a	n/a	n/a	n/a	8.0	30
PROBIODRUG AG US Patent					Assay Description All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...				US Patent US9512115 (2016) BindingDB Entry DOI: 10.7270/Q2XK8DG4
					More data for this Ligand-Target Pair
Glutaminyl-peptide cyclotransferase (Homo sapiens (Human))	BDBM50299858 (1-(3,4-Dimethoxyphenyl)-N-(3-(5-methyl-1H-imidazol...) Show SMILES COc1ccc(cc1OC)C1(CC1)C(=S)NCCCn1cncc1C Show InChI InChI=1S/C19H25N3O2S/c1-14-12-20-13-22(14)10-4-9-21-18(25)19(7-8-19)15-5-6-16(23-2)17(11-15)24-3/h5-6,11-13H,4,7-10H2,1-3H3,(H,21,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Probiodrug AG Curated by ChEMBL					Assay Description Inhibition of human glutaminyl cyclase expressed in Pichia pastoris by pGAP coupled enzyme assay				J Med Chem 52: 7069-80 (2009) Article DOI: 10.1021/jm900969p BindingDB Entry DOI: 10.7270/Q2Q2409C
					More data for this Ligand-Target Pair
Glutaminyl-peptide cyclotransferase (Homo sapiens (Human))	BDBM259914 (US9512115, 18) Show SMILES Fc1cc(ccc1[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1)N1CCC(F)(F)C1 |r| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	2.69	-49.7	n/a	n/a	n/a	n/a	n/a	6.0	30
PROBIODRUG AG US Patent					Assay Description All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...				US Patent US9512115 (2016) BindingDB Entry DOI: 10.7270/Q2XK8DG4
					More data for this Ligand-Target Pair
Glutaminyl-peptide cyclotransferase (Homo sapiens (Human))	BDBM259898 (US9512115, 1) Show SMILES CC(F)(F)CCOc1ccc([C@H]2COC(=O)N2c2ccc3[nH]cnc3c2)c(F)c1F |r| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	2.90	-49.5	n/a	n/a	n/a	n/a	n/a	6.0	30
PROBIODRUG AG US Patent					Assay Description All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...				US Patent US9512115 (2016) BindingDB Entry DOI: 10.7270/Q2XK8DG4
					More data for this Ligand-Target Pair
Glutaminyl-peptide cyclotransferase (Homo sapiens (Human))	BDBM259914 (US9512115, 18) Show SMILES Fc1cc(ccc1[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1)N1CCC(F)(F)C1 |r| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	2.92	-49.5	n/a	n/a	n/a	n/a	n/a	8.0	30
PROBIODRUG AG US Patent					Assay Description All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...				US Patent US9512115 (2016) BindingDB Entry DOI: 10.7270/Q2XK8DG4
					More data for this Ligand-Target Pair
Glutaminyl-peptide cyclotransferase (Homo sapiens (Human))	BDBM149365 (US8962860, 9) Show SMILES COc1ccc(cc1O)C1N(C(=O)NC1=O)c1ccc2[nH]cnc2c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	3.24	-49.3	3.08	n/a	n/a	n/a	n/a	n/a	30
Probiodrug AG US Patent					Assay Description This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...				US Patent US8962860 (2015) BindingDB Entry DOI: 10.7270/Q2B856V2
					More data for this Ligand-Target Pair
Glutaminyl-peptide cyclotransferase (Homo sapiens (Human))	BDBM259907 (US9512115, 11) Show SMILES FC(F)CCOc1ccc([C@H]2COC(=O)N2c2ccc3[nH]cnc3c2)c(F)c1F |r| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	3.34	-49.2	n/a	n/a	n/a	n/a	n/a	6.0	30
PROBIODRUG AG US Patent					Assay Description All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...				US Patent US9512115 (2016) BindingDB Entry DOI: 10.7270/Q2XK8DG4
					More data for this Ligand-Target Pair
Glutaminyl-peptide cyclotransferase (Homo sapiens (Human))	BDBM259898 (US9512115, 1) Show SMILES CC(F)(F)CCOc1ccc([C@H]2COC(=O)N2c2ccc3[nH]cnc3c2)c(F)c1F |r| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	3.58	-49.0	n/a	n/a	n/a	n/a	n/a	8.0	30
PROBIODRUG AG US Patent					Assay Description All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...				US Patent US9512115 (2016) BindingDB Entry DOI: 10.7270/Q2XK8DG4
					More data for this Ligand-Target Pair
Glutaminyl-peptide cyclotransferase (Homo sapiens (Human))	BDBM149363 (US8962860, 6) Show SMILES CCCOc1ccc(cc1)C1N(C(=O)NC1=O)c1ccc2[nH]cnc2c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	3.80	-48.9	234	n/a	n/a	n/a	n/a	n/a	30
Probiodrug AG US Patent					Assay Description This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...				US Patent US8962860 (2015) BindingDB Entry DOI: 10.7270/Q2B856V2
					More data for this Ligand-Target Pair
Glutaminyl-peptide cyclotransferase (Homo sapiens (Human))	BDBM149366 (US8962860, 11) Show SMILES O=C1NC(=O)N(C1c1ccc(cc1)-c1ccccc1)c1ccc2[nH]cnc2c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	4.13	-48.7	48	n/a	n/a	n/a	n/a	n/a	30
Probiodrug AG US Patent					Assay Description This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...				US Patent US8962860 (2015) BindingDB Entry DOI: 10.7270/Q2B856V2
					More data for this Ligand-Target Pair
Glutaminyl-peptide cyclotransferase (Homo sapiens (Human))	BDBM259916 (US9512115, 20) Show SMILES Fc1cc(cc(F)c1[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1)N1CCC(F)(F)C1 |r| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	4.53	-48.4	n/a	n/a	n/a	n/a	n/a	6.0	30
PROBIODRUG AG US Patent					Assay Description All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...				US Patent US9512115 (2016) BindingDB Entry DOI: 10.7270/Q2XK8DG4
					More data for this Ligand-Target Pair
Glutaminyl-peptide cyclotransferase (Homo sapiens (Human))	BDBM259900 (US9512115, 3) Show SMILES CC(F)(F)CCOc1ccc([C@H]2COC(=O)N2c2ccc3[nH]cnc3c2)c(F)c1 |r| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	5.02	-48.2	n/a	n/a	n/a	n/a	n/a	8.0	30
PROBIODRUG AG US Patent					Assay Description All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...				US Patent US9512115 (2016) BindingDB Entry DOI: 10.7270/Q2XK8DG4
					More data for this Ligand-Target Pair
Glutaminyl-peptide cyclotransferase (Homo sapiens (Human))	BDBM259900 (US9512115, 3) Show SMILES CC(F)(F)CCOc1ccc([C@H]2COC(=O)N2c2ccc3[nH]cnc3c2)c(F)c1 |r| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	5.03	-48.2	n/a	n/a	n/a	n/a	n/a	6.0	30
PROBIODRUG AG US Patent					Assay Description All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...				US Patent US9512115 (2016) BindingDB Entry DOI: 10.7270/Q2XK8DG4
					More data for this Ligand-Target Pair
Glutaminyl-peptide cyclotransferase (Homo sapiens (Human))	BDBM259919 (US9512115, 23) Show SMILES FC1(F)CCN(C1)c1ccc([C@H]2COC(=O)N2c2ccc3[nH]cnc3c2)c(c1)C#N |r| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	5.15	-48.1	n/a	n/a	n/a	n/a	n/a	6.0	30
PROBIODRUG AG US Patent					Assay Description All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...				US Patent US9512115 (2016) BindingDB Entry DOI: 10.7270/Q2XK8DG4
					More data for this Ligand-Target Pair
Glutaminyl-peptide cyclotransferase (Homo sapiens (Human))	BDBM259916 (US9512115, 20) Show SMILES Fc1cc(cc(F)c1[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1)N1CCC(F)(F)C1 |r| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	5.29	-48.0	n/a	n/a	n/a	n/a	n/a	8.0	30
PROBIODRUG AG US Patent					Assay Description All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...				US Patent US9512115 (2016) BindingDB Entry DOI: 10.7270/Q2XK8DG4
					More data for this Ligand-Target Pair
Glutaminyl-peptide cyclotransferase (Homo sapiens (Human))	BDBM259907 (US9512115, 11) Show SMILES FC(F)CCOc1ccc([C@H]2COC(=O)N2c2ccc3[nH]cnc3c2)c(F)c1F |r| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	5.54	-47.9	n/a	n/a	n/a	n/a	n/a	8.0	30
PROBIODRUG AG US Patent					Assay Description All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...				US Patent US9512115 (2016) BindingDB Entry DOI: 10.7270/Q2XK8DG4
					More data for this Ligand-Target Pair
Glutaminyl-peptide cyclotransferase (Homo sapiens (Human))	BDBM149358 (US8962860, 1) Show SMILES O=C1NC(=O)N(C1c1ccc2nsnc2c1)c1ccc2[nH]cnc2c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	6.07	-47.7	69.7	n/a	n/a	n/a	n/a	n/a	30
Probiodrug AG US Patent					Assay Description This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...				US Patent US8962860 (2015) BindingDB Entry DOI: 10.7270/Q2B856V2
					More data for this Ligand-Target Pair
Glutaminyl-peptide cyclotransferase (Homo sapiens (Human))	BDBM259903 (US9512115, 6) Show SMILES CC(F)(F)COc1ccc([C@H]2COC(=O)N2c2ccc3[nH]cnc3c2)c(F)c1F |r| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	6.21	-47.6	n/a	n/a	n/a	n/a	n/a	6.0	30
PROBIODRUG AG US Patent					Assay Description All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...				US Patent US9512115 (2016) BindingDB Entry DOI: 10.7270/Q2XK8DG4
					More data for this Ligand-Target Pair
Glutaminyl-peptide cyclotransferase (Homo sapiens (Human))	BDBM50299853 (1-(3,4-Dimethoxyphenyl)-3-(3-(5-methyl-1H-imidazol...) Show SMILES COc1ccc(NC(=S)NCCCn2cncc2C)cc1OC Show InChI InChI=1S/C16H22N4O2S/c1-12-10-17-11-20(12)8-4-7-18-16(23)19-13-5-6-14(21-2)15(9-13)22-3/h5-6,9-11H,4,7-8H2,1-3H3,(H2,18,19,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	6.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Probiodrug AG Curated by ChEMBL					Assay Description Inhibition of human glutaminyl cyclase expressed in Pichia pastoris by pGAP coupled enzyme assay				J Med Chem 52: 7069-80 (2009) Article DOI: 10.1021/jm900969p BindingDB Entry DOI: 10.7270/Q2Q2409C
					More data for this Ligand-Target Pair				3D Structure (docked)
Glutaminyl-peptide cyclotransferase (Homo sapiens (Human))	BDBM149375 (US8962860, 42) Show SMILES Fc1cc(Br)ccc1C1N(C(=O)NC1=S)c1ccc2nc[nH]c2c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	6.49	-47.5	24	n/a	n/a	n/a	n/a	n/a	30
Probiodrug AG US Patent					Assay Description This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...				US Patent US8962860 (2015) BindingDB Entry DOI: 10.7270/Q2B856V2
					More data for this Ligand-Target Pair
Glutaminyl-peptide cyclotransferase (Homo sapiens (Human))	BDBM259899 (US9512115, 2) Show SMILES FC(F)CCOc1ccc([C@H]2COC(=O)N2c2ccc3[nH]cnc3c2)c(F)c1 |r| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	6.54	-47.5	n/a	n/a	n/a	n/a	n/a	8.0	30
PROBIODRUG AG US Patent					Assay Description All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...				US Patent US9512115 (2016) BindingDB Entry DOI: 10.7270/Q2XK8DG4
					More data for this Ligand-Target Pair
Glutaminyl-peptide cyclotransferase (Homo sapiens (Human))	BDBM259913 (US9512115, 17) Show SMILES CC(F)(F)COc1cc(F)c([C@H]2COC(=O)N2c2ccc3[nH]cnc3c2)c(F)c1 |r| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	6.66	-47.4	n/a	n/a	n/a	n/a	n/a	6.0	30
PROBIODRUG AG US Patent					Assay Description All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...				US Patent US9512115 (2016) BindingDB Entry DOI: 10.7270/Q2XK8DG4
					More data for this Ligand-Target Pair
Glutaminyl-peptide cyclotransferase (Homo sapiens (Human))	BDBM259903 (US9512115, 6) Show SMILES CC(F)(F)COc1ccc([C@H]2COC(=O)N2c2ccc3[nH]cnc3c2)c(F)c1F |r| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	6.71	-47.4	n/a	n/a	n/a	n/a	n/a	8.0	30
PROBIODRUG AG US Patent					Assay Description All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...				US Patent US9512115 (2016) BindingDB Entry DOI: 10.7270/Q2XK8DG4
					More data for this Ligand-Target Pair
Glutaminyl-peptide cyclotransferase (Homo sapiens (Human))	BDBM259919 (US9512115, 23) Show SMILES FC1(F)CCN(C1)c1ccc([C@H]2COC(=O)N2c2ccc3[nH]cnc3c2)c(c1)C#N |r| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	7.89	-47.0	n/a	n/a	n/a	n/a	n/a	8.0	30
PROBIODRUG AG US Patent					Assay Description All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...				US Patent US9512115 (2016) BindingDB Entry DOI: 10.7270/Q2XK8DG4
					More data for this Ligand-Target Pair
Glutaminyl-peptide cyclotransferase (Homo sapiens (Human))	BDBM259913 (US9512115, 17) Show SMILES CC(F)(F)COc1cc(F)c([C@H]2COC(=O)N2c2ccc3[nH]cnc3c2)c(F)c1 |r| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	8.29	-46.9	n/a	n/a	n/a	n/a	n/a	8.0	30
PROBIODRUG AG US Patent					Assay Description All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...				US Patent US9512115 (2016) BindingDB Entry DOI: 10.7270/Q2XK8DG4
					More data for this Ligand-Target Pair
Glutaminyl-peptide cyclotransferase (Homo sapiens (Human))	BDBM259899 (US9512115, 2) Show SMILES FC(F)CCOc1ccc([C@H]2COC(=O)N2c2ccc3[nH]cnc3c2)c(F)c1 |r| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	8.5	-46.8	n/a	n/a	n/a	n/a	n/a	6.0	30
PROBIODRUG AG US Patent					Assay Description All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...				US Patent US9512115 (2016) BindingDB Entry DOI: 10.7270/Q2XK8DG4
					More data for this Ligand-Target Pair
Glutaminyl-peptide cyclotransferase (Homo sapiens (Human))	BDBM259906 (US9512115, 10) Show SMILES CC(F)(F)CCOc1ccc(cc1F)[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1 |r| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	8.95	-46.7	n/a	n/a	n/a	n/a	n/a	6.0	30
PROBIODRUG AG US Patent					Assay Description All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...				US Patent US9512115 (2016) BindingDB Entry DOI: 10.7270/Q2XK8DG4
					More data for this Ligand-Target Pair
Glutaminyl-peptide cyclotransferase (Homo sapiens (Human))	BDBM259906 (US9512115, 10) Show SMILES CC(F)(F)CCOc1ccc(cc1F)[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1 |r| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	8.99	-46.7	n/a	n/a	n/a	n/a	n/a	8.0	30
PROBIODRUG AG US Patent					Assay Description All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...				US Patent US9512115 (2016) BindingDB Entry DOI: 10.7270/Q2XK8DG4
					More data for this Ligand-Target Pair
Glutaminyl-peptide cyclotransferase (Homo sapiens (Human))	BDBM259921 (US9512115, 25) Show SMILES Fc1cc(ccc1[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1)C1CCC(F)(F)CC1 |r| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	9.24	-46.6	n/a	n/a	n/a	n/a	n/a	6.0	30
PROBIODRUG AG US Patent					Assay Description All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...				US Patent US9512115 (2016) BindingDB Entry DOI: 10.7270/Q2XK8DG4
					More data for this Ligand-Target Pair
Glutaminyl-peptide cyclotransferase (Homo sapiens (Human))	BDBM259904 (US9512115, 7) Show SMILES CC(C)(F)COc1ccc([C@H]2COC(=O)N2c2ccc3[nH]cnc3c2)c(F)c1 |r| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	9.83	-46.5	n/a	n/a	n/a	n/a	n/a	6.0	30
PROBIODRUG AG US Patent					Assay Description All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...				US Patent US9512115 (2016) BindingDB Entry DOI: 10.7270/Q2XK8DG4
					More data for this Ligand-Target Pair
Glutaminyl-peptide cyclotransferase-like protein (Homo sapiens (Human))	BDBM190690 (US9181233, 67) Show SMILES COc1ccc(SCc2nnc(s2)-c2ccc3[nH]cnc3c2)cc1OC Show InChI InChI=1S/C18H16N4O2S2/c1-23-15-6-4-12(8-16(15)24-2)25-9-17-21-22-18(26-17)11-3-5-13-14(7-11)20-10-19-13/h3-8,10H,9H2,1-2H3,(H,19,20)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	10	-46.4	80	n/a	n/a	n/a	n/a	n/a	30
PROBIODRUG AG US Patent					Assay Description This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...				US Patent US9181233 (2015) BindingDB Entry DOI: 10.7270/Q2S46QQH
					More data for this Ligand-Target Pair
Glutaminyl-peptide cyclotransferase (Homo sapiens (Human))	BDBM259917 (US9512115, 21) Show SMILES Fc1cc(ccc1N1CCC(F)(F)C1)[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1 |r| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	10.4	-46.3	n/a	n/a	n/a	n/a	n/a	6.0	30
PROBIODRUG AG US Patent					Assay Description All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...				US Patent US9512115 (2016) BindingDB Entry DOI: 10.7270/Q2XK8DG4
					More data for this Ligand-Target Pair
Glutaminyl-peptide cyclotransferase (Homo sapiens (Human))	BDBM259904 (US9512115, 7) Show SMILES CC(C)(F)COc1ccc([C@H]2COC(=O)N2c2ccc3[nH]cnc3c2)c(F)c1 |r| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	10.9	-46.2	n/a	n/a	n/a	n/a	n/a	8.0	30
PROBIODRUG AG US Patent					Assay Description All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...				US Patent US9512115 (2016) BindingDB Entry DOI: 10.7270/Q2XK8DG4
					More data for this Ligand-Target Pair
Glutaminyl-peptide cyclotransferase (Homo sapiens (Human))	BDBM259921 (US9512115, 25) Show SMILES Fc1cc(ccc1[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1)C1CCC(F)(F)CC1 |r| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	11.3	-46.1	n/a	n/a	n/a	n/a	n/a	8.0	30
PROBIODRUG AG US Patent					Assay Description All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...				US Patent US9512115 (2016) BindingDB Entry DOI: 10.7270/Q2XK8DG4
					More data for this Ligand-Target Pair
Glutaminyl-peptide cyclotransferase (Homo sapiens (Human))	BDBM259920 (US9512115, 24) Show SMILES FC1(F)CCN(C1)c1ccc(cc1C#N)[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1 |r| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	11.4	-46.1	n/a	n/a	n/a	n/a	n/a	6.0	30
PROBIODRUG AG US Patent					Assay Description All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...				US Patent US9512115 (2016) BindingDB Entry DOI: 10.7270/Q2XK8DG4
					More data for this Ligand-Target Pair
Glutaminyl-peptide cyclotransferase (Homo sapiens (Human))	BDBM259926 (US9512115, 30) Show SMILES CC(F)(F)CCc1ccc([C@H]2COC(=O)N2c2ccc3[nH]cnc3c2)c(F)c1 |r| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	12.0	-46.0	n/a	n/a	n/a	n/a	n/a	6.0	30
PROBIODRUG AG US Patent					Assay Description All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...				US Patent US9512115 (2016) BindingDB Entry DOI: 10.7270/Q2XK8DG4
					More data for this Ligand-Target Pair
Glutaminyl-peptide cyclotransferase (Homo sapiens (Human))	BDBM259926 (US9512115, 30) Show SMILES CC(F)(F)CCc1ccc([C@H]2COC(=O)N2c2ccc3[nH]cnc3c2)c(F)c1 |r| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	12.2	-45.9	n/a	n/a	n/a	n/a	n/a	8.0	30
PROBIODRUG AG US Patent					Assay Description All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...				US Patent US9512115 (2016) BindingDB Entry DOI: 10.7270/Q2XK8DG4
					More data for this Ligand-Target Pair
Glutaminyl-peptide cyclotransferase (Homo sapiens (Human))	BDBM98187 (US8486940, 89 | US9650362, 89) Show SMILES O=C1OC[C@@H](N1c1ccc2nc[nH]c2c1)c1ccc(cc1)N1CCN(CC1)c1ccccc1 |r| Show InChI InChI=1S/C26H25N5O2/c32-26-31(22-10-11-23-24(16-22)28-18-27-23)25(17-33-26)19-6-8-21(9-7-19)30-14-12-29(13-15-30)20-4-2-1-3-5-20/h1-11,16,18,25H,12-15,17H2,(H,27,28)/t25-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	12.5	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
Probiodrug AG US Patent					Assay Description Spectrophotometic Assay: This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spect...				US Patent US8486940 (2013) BindingDB Entry DOI: 10.7270/Q2251GSF
					More data for this Ligand-Target Pair
Glutaminyl-peptide cyclotransferase (Homo sapiens (Human))	BDBM98187 (US8486940, 89 | US9650362, 89) Show SMILES O=C1OC[C@@H](N1c1ccc2nc[nH]c2c1)c1ccc(cc1)N1CCN(CC1)c1ccccc1 |r| Show InChI InChI=1S/C26H25N5O2/c32-26-31(22-10-11-23-24(16-22)28-18-27-23)25(17-33-26)19-6-8-21(9-7-19)30-14-12-29(13-15-30)20-4-2-1-3-5-20/h1-11,16,18,25H,12-15,17H2,(H,27,28)/t25-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	12.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
PROBIODRUG AG US Patent					Assay Description All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometrical...				US Patent US9650362 (2017) BindingDB Entry DOI: 10.7270/Q2VD71H9
					More data for this Ligand-Target Pair
Glutaminyl-peptide cyclotransferase (Homo sapiens (Human))	BDBM259901 (US9512115, 4) Show SMILES FC(F)CCOc1ccc(cc1)[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1 |r| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	12.6	-45.8	n/a	n/a	n/a	n/a	n/a	6.0	30
PROBIODRUG AG US Patent					Assay Description All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...				US Patent US9512115 (2016) BindingDB Entry DOI: 10.7270/Q2XK8DG4
					More data for this Ligand-Target Pair
Glutaminyl-peptide cyclotransferase (Homo sapiens (Human))	BDBM259909 (US9512115, 13) Show SMILES FC(F)CCOc1c(F)cc(cc1F)[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1 |r| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	13.1	-45.7	n/a	n/a	n/a	n/a	n/a	6.0	30
PROBIODRUG AG US Patent					Assay Description All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...				US Patent US9512115 (2016) BindingDB Entry DOI: 10.7270/Q2XK8DG4
					More data for this Ligand-Target Pair
Glutaminyl-peptide cyclotransferase (Homo sapiens (Human))	BDBM259908 (US9512115, 12) Show SMILES FC(F)CCOc1ccc(cc1F)[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1 |r| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	13.1	-45.7	n/a	n/a	n/a	n/a	n/a	6.0	30
PROBIODRUG AG US Patent					Assay Description All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...				US Patent US9512115 (2016) BindingDB Entry DOI: 10.7270/Q2XK8DG4
					More data for this Ligand-Target Pair
Glutaminyl-peptide cyclotransferase (Homo sapiens (Human))	BDBM259922 (US9512115, 26) Show SMILES Fc1cc(ccc1C1CCC(F)(F)CC1)[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1 |r| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	13.6	-45.7	n/a	n/a	n/a	n/a	n/a	6.0	30
PROBIODRUG AG US Patent					Assay Description All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...				US Patent US9512115 (2016) BindingDB Entry DOI: 10.7270/Q2XK8DG4
					More data for this Ligand-Target Pair
Glutaminyl-peptide cyclotransferase (Homo sapiens (Human))	BDBM149371 (US8962860, 16) Show SMILES O=C1NC(=O)N(C1c1ccc2OCCOc2c1)c1ccc2[nH]cnc2c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	13.6	-45.7	128	n/a	n/a	n/a	n/a	n/a	30
Probiodrug AG US Patent					Assay Description This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...				US Patent US8962860 (2015) BindingDB Entry DOI: 10.7270/Q2B856V2
					More data for this Ligand-Target Pair
Glutaminyl-peptide cyclotransferase (Homo sapiens (Human))	BDBM259922 (US9512115, 26) Show SMILES Fc1cc(ccc1C1CCC(F)(F)CC1)[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1 |r| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	14.3	-45.5	n/a	n/a	n/a	n/a	n/a	8.0	30
PROBIODRUG AG US Patent					Assay Description All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...				US Patent US9512115 (2016) BindingDB Entry DOI: 10.7270/Q2XK8DG4
					More data for this Ligand-Target Pair
Glutaminyl-peptide cyclotransferase (Homo sapiens (Human))	BDBM259924 (US9512115, 28) Show SMILES CC(F)(F)CCc1ccc([C@H]2COC(=O)N2c2ccc3[nH]cnc3c2)c(F)c1F |r| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	14.9	-45.4	n/a	n/a	n/a	n/a	n/a	8.0	30
PROBIODRUG AG US Patent					Assay Description All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...				US Patent US9512115 (2016) BindingDB Entry DOI: 10.7270/Q2XK8DG4
					More data for this Ligand-Target Pair
Glutaminyl-peptide cyclotransferase (Homo sapiens (Human))	BDBM259918 (US9512115, 22) Show SMILES FC1(F)CCN(C1)c1ccc(cc1)[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1 |r| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	15.1	-45.4	n/a	n/a	n/a	n/a	n/a	8.0	30
PROBIODRUG AG US Patent					Assay Description All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...				US Patent US9512115 (2016) BindingDB Entry DOI: 10.7270/Q2XK8DG4
					More data for this Ligand-Target Pair
Glutaminyl-peptide cyclotransferase (Homo sapiens (Human))	BDBM259908 (US9512115, 12) Show SMILES FC(F)CCOc1ccc(cc1F)[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1 |r| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	15.4	-45.3	n/a	n/a	n/a	n/a	n/a	8.0	30
PROBIODRUG AG US Patent					Assay Description All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...				US Patent US9512115 (2016) BindingDB Entry DOI: 10.7270/Q2XK8DG4
					More data for this Ligand-Target Pair
Glutaminyl-peptide cyclotransferase (Homo sapiens (Human))	BDBM259923 (US9512115, 27) Show SMILES FC1(F)CCC(CC1)c1ccc(cc1)[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1 |r| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	15.4	-45.3	n/a	n/a	n/a	n/a	n/a	6.0	30
PROBIODRUG AG US Patent					Assay Description All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...				US Patent US9512115 (2016) BindingDB Entry DOI: 10.7270/Q2XK8DG4
					More data for this Ligand-Target Pair

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