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Compile Data Set for Download or QSAR

Found 56 hits Enz. Inhib. hit(s) with all data for entry = 7523   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Endothelial lipase


(Mus musculus (Mouse))
BDBM199225
PNG
(US9216998, 8)
Show SMILES Nc1cc2CCCn3c(CCCOc4ccccc4)c(c(c1)c23)C(F)(F)F
Show InChI InChI=1S/C21H21F3N2O/c22-21(23,24)19-17-13-15(25)12-14-6-4-10-26(20(14)17)18(19)9-5-11-27-16-7-2-1-3-8-16/h1-3,7-8,12-13H,4-6,9-11,25H2
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n/an/a 4n/an/an/an/a7.2n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...


US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM199225
PNG
(US9216998, 8)
Show SMILES Nc1cc2CCCn3c(CCCOc4ccccc4)c(c(c1)c23)C(F)(F)F
Show InChI InChI=1S/C21H21F3N2O/c22-21(23,24)19-17-13-15(25)12-14-6-4-10-26(20(14)17)18(19)9-5-11-27-16-7-2-1-3-8-16/h1-3,7-8,12-13H,4-6,9-11,25H2
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...


US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM50443627
PNG
(CHEMBL3092450 | US9216998, 5)
Show SMILES COc1cc2CCCn3c(CCc4ccccc4)c(c(c1)c23)C(F)(F)F
Show InChI InChI=1S/C21H20F3NO/c1-26-16-12-15-8-5-11-25-18(10-9-14-6-3-2-4-7-14)19(21(22,23)24)17(13-16)20(15)25/h2-4,6-7,12-13H,5,8-11H2,1H3
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...


US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM199219
PNG
(US9216998, 7 | US9216998, Reference Compound 2)
Show SMILES FC(F)(F)c1c(CCc2ccccc2)n2CCCc3cccc1c23
Show InChI InChI=1S/C20H18F3N/c21-20(22,23)18-16-10-4-8-15-9-5-13-24(19(15)16)17(18)12-11-14-6-2-1-3-7-14/h1-4,6-8,10H,5,9,11-13H2
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...


US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))
BDBM50443627
PNG
(CHEMBL3092450 | US9216998, 5)
Show SMILES COc1cc2CCCn3c(CCc4ccccc4)c(c(c1)c23)C(F)(F)F
Show InChI InChI=1S/C21H20F3NO/c1-26-16-12-15-8-5-11-25-18(10-9-14-6-3-2-4-7-14)19(21(22,23)24)17(13-16)20(15)25/h2-4,6-7,12-13H,5,8-11H2,1H3
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...


US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM199219
PNG
(US9216998, 7 | US9216998, Reference Compound 2)
Show SMILES FC(F)(F)c1c(CCc2ccccc2)n2CCCc3cccc1c23
Show InChI InChI=1S/C20H18F3N/c21-20(22,23)18-16-10-4-8-15-9-5-13-24(19(15)16)17(18)12-11-14-6-2-1-3-7-14/h1-4,6-8,10H,5,9,11-13H2
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...


US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))
BDBM199219
PNG
(US9216998, 7 | US9216998, Reference Compound 2)
Show SMILES FC(F)(F)c1c(CCc2ccccc2)n2CCCc3cccc1c23
Show InChI InChI=1S/C20H18F3N/c21-20(22,23)18-16-10-4-8-15-9-5-13-24(19(15)16)17(18)12-11-14-6-2-1-3-7-14/h1-4,6-8,10H,5,9,11-13H2
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...


US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))
BDBM50443625
PNG
(CHEMBL3092448 | US9216998, 25)
Show SMILES FC(F)(F)c1c(CCc2ccccc2)n2CCOc3cccc1c23
Show InChI InChI=1S/C19H16F3NO/c20-19(21,22)17-14-7-4-8-16-18(14)23(11-12-24-16)15(17)10-9-13-5-2-1-3-6-13/h1-8H,9-12H2
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...


US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))
BDBM199205
PNG
(US9216998, 9)
Show SMILES FC(F)(F)c1c(CCc2ccccc2)n2CCCCc3cccc1c23
Show InChI InChI=1S/C21H20F3N/c22-21(23,24)19-17-11-6-10-16-9-4-5-14-25(20(16)17)18(19)13-12-15-7-2-1-3-8-15/h1-3,6-8,10-11H,4-5,9,12-14H2
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...


US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM50443625
PNG
(CHEMBL3092448 | US9216998, 25)
Show SMILES FC(F)(F)c1c(CCc2ccccc2)n2CCOc3cccc1c23
Show InChI InChI=1S/C19H16F3NO/c20-19(21,22)17-14-7-4-8-16-18(14)23(11-12-24-16)15(17)10-9-13-5-2-1-3-6-13/h1-8H,9-12H2
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...


US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM199205
PNG
(US9216998, 9)
Show SMILES FC(F)(F)c1c(CCc2ccccc2)n2CCCCc3cccc1c23
Show InChI InChI=1S/C21H20F3N/c22-21(23,24)19-17-11-6-10-16-9-4-5-14-25(20(16)17)18(19)13-12-15-7-2-1-3-8-15/h1-3,6-8,10-11H,4-5,9,12-14H2
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...


US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))
BDBM199219
PNG
(US9216998, 7 | US9216998, Reference Compound 2)
Show SMILES FC(F)(F)c1c(CCc2ccccc2)n2CCCc3cccc1c23
Show InChI InChI=1S/C20H18F3N/c21-20(22,23)18-16-10-4-8-15-9-5-13-24(19(15)16)17(18)12-11-14-6-2-1-3-7-14/h1-4,6-8,10H,5,9,11-13H2
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...


US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM199226
PNG
(US9216998, 10)
Show SMILES FC(F)(F)c1c(Cc2ccccc2)n2CCCCc3cccc1c23
Show InChI InChI=1S/C20H18F3N/c21-20(22,23)18-16-11-6-10-15-9-4-5-12-24(19(15)16)17(18)13-14-7-2-1-3-8-14/h1-3,6-8,10-11H,4-5,9,12-13H2
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...


US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM199207
PNG
(US9216998, 19)
Show SMILES NS(=O)(=O)N1CCn2c(CCc3ccccc3)c(c3cccc(C1)c23)C(F)(F)F
Show InChI InChI=1S/C20H20F3N3O2S/c21-20(22,23)18-16-8-4-7-15-13-25(29(24,27)28)11-12-26(19(15)16)17(18)10-9-14-5-2-1-3-6-14/h1-8H,9-13H2,(H2,24,27,28)
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...


US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM199223
PNG
(US9216998, 6)
Show SMILES Oc1cc2CCCn3c(CCc4ccccc4)c(c(c1)c23)C(F)(F)F
Show InChI InChI=1S/C20H18F3NO/c21-20(22,23)18-16-12-15(25)11-14-7-4-10-24(19(14)16)17(18)9-8-13-5-2-1-3-6-13/h1-3,5-6,11-12,25H,4,7-10H2
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...


US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))
BDBM199226
PNG
(US9216998, 10)
Show SMILES FC(F)(F)c1c(Cc2ccccc2)n2CCCCc3cccc1c23
Show InChI InChI=1S/C20H18F3N/c21-20(22,23)18-16-11-6-10-15-9-4-5-12-24(19(15)16)17(18)13-14-7-2-1-3-8-14/h1-3,6-8,10-11H,4-5,9,12-13H2
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...


US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM199229
PNG
(US9216998, 27)
Show SMILES FC(F)(F)c1c(CCCOc2ccccc2)n2CCOc3cccc1c23
Show InChI InChI=1S/C20H18F3NO2/c21-20(22,23)18-15-8-4-10-17-19(15)24(11-13-26-17)16(18)9-5-12-25-14-6-2-1-3-7-14/h1-4,6-8,10H,5,9,11-13H2
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...


US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))
BDBM199207
PNG
(US9216998, 19)
Show SMILES NS(=O)(=O)N1CCn2c(CCc3ccccc3)c(c3cccc(C1)c23)C(F)(F)F
Show InChI InChI=1S/C20H20F3N3O2S/c21-20(22,23)18-16-8-4-7-15-13-25(29(24,27)28)11-12-26(19(15)16)17(18)10-9-14-5-2-1-3-6-14/h1-8H,9-13H2,(H2,24,27,28)
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...


US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))
BDBM199221
PNG
(US9216998, 3)
Show SMILES FC(F)(F)c1c(Cc2ccccc2)n2CCCc3cccc1c23
Show InChI InChI=1S/C19H16F3N/c20-19(21,22)17-15-10-4-8-14-9-5-11-23(18(14)15)16(17)12-13-6-2-1-3-7-13/h1-4,6-8,10H,5,9,11-12H2
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...


US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM199216
PNG
(US9216998, 22)
Show SMILES CC(CC(=O)N1CCn2c(CCc3ccccc3)c(c3cccc(C1)c23)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C25H24F6N2O/c1-16(24(26,27)28)14-21(34)32-12-13-33-20(11-10-17-6-3-2-4-7-17)22(25(29,30)31)19-9-5-8-18(15-32)23(19)33/h2-9,16H,10-15H2,1H3
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...


US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))
BDBM199229
PNG
(US9216998, 27)
Show SMILES FC(F)(F)c1c(CCCOc2ccccc2)n2CCOc3cccc1c23
Show InChI InChI=1S/C20H18F3NO2/c21-20(22,23)18-15-8-4-10-17-19(15)24(11-13-26-17)16(18)9-5-12-25-14-6-2-1-3-7-14/h1-4,6-8,10H,5,9,11-13H2
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...


US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM199221
PNG
(US9216998, 3)
Show SMILES FC(F)(F)c1c(Cc2ccccc2)n2CCCc3cccc1c23
Show InChI InChI=1S/C19H16F3N/c20-19(21,22)17-15-10-4-8-14-9-5-11-23(18(14)15)16(17)12-13-6-2-1-3-7-13/h1-4,6-8,10H,5,9,11-12H2
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...


US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))
BDBM199209
PNG
(US9216998, 13)
Show SMILES CC(C)(C)OC(=O)N1CCn2c(CCc3ccccc3)c(c3cccc(C1)c23)C(F)(F)F
Show InChI InChI=1S/C25H27F3N2O2/c1-24(2,3)32-23(31)29-14-15-30-20(13-12-17-8-5-4-6-9-17)21(25(26,27)28)19-11-7-10-18(16-29)22(19)30/h4-11H,12-16H2,1-3H3
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...


US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))
BDBM199208
PNG
(US9216998, 12)
Show SMILES CC(C)NC(=O)N1CCn2c(CCc3ccccc3)c(c3cccc(C1)c23)C(F)(F)F
Show InChI InChI=1S/C24H26F3N3O/c1-16(2)28-23(31)29-13-14-30-20(12-11-17-7-4-3-5-8-17)21(24(25,26)27)19-10-6-9-18(15-29)22(19)30/h3-10,16H,11-15H2,1-2H3,(H,28,31)
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...


US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM199208
PNG
(US9216998, 12)
Show SMILES CC(C)NC(=O)N1CCn2c(CCc3ccccc3)c(c3cccc(C1)c23)C(F)(F)F
Show InChI InChI=1S/C24H26F3N3O/c1-16(2)28-23(31)29-13-14-30-20(12-11-17-7-4-3-5-8-17)21(24(25,26)27)19-10-6-9-18(15-29)22(19)30/h3-10,16H,11-15H2,1-2H3,(H,28,31)
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...


US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))
BDBM199223
PNG
(US9216998, 6)
Show SMILES Oc1cc2CCCn3c(CCc4ccccc4)c(c(c1)c23)C(F)(F)F
Show InChI InChI=1S/C20H18F3NO/c21-20(22,23)18-16-12-15(25)11-14-7-4-10-24(19(14)16)17(18)9-8-13-5-2-1-3-6-13/h1-3,5-6,11-12,25H,4,7-10H2
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...


US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))
BDBM199216
PNG
(US9216998, 22)
Show SMILES CC(CC(=O)N1CCn2c(CCc3ccccc3)c(c3cccc(C1)c23)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C25H24F6N2O/c1-16(24(26,27)28)14-21(34)32-12-13-33-20(11-10-17-6-3-2-4-7-17)22(25(29,30)31)19-9-5-8-18(15-32)23(19)33/h2-9,16H,10-15H2,1H3
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...


US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM199222
PNG
(US9216998, 4)
Show SMILES FC(F)(F)c1c(CCCc2ccccc2)n2CCCc3cccc1c23
Show InChI InChI=1S/C21H20F3N/c22-21(23,24)19-17-12-5-10-16-11-6-14-25(20(16)17)18(19)13-4-9-15-7-2-1-3-8-15/h1-3,5,7-8,10,12H,4,6,9,11,13-14H2
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...


US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM199209
PNG
(US9216998, 13)
Show SMILES CC(C)(C)OC(=O)N1CCn2c(CCc3ccccc3)c(c3cccc(C1)c23)C(F)(F)F
Show InChI InChI=1S/C25H27F3N2O2/c1-24(2,3)32-23(31)29-14-15-30-20(13-12-17-8-5-4-6-9-17)21(25(26,27)28)19-11-7-10-18(16-29)22(19)30/h4-11H,12-16H2,1-3H3
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...


US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))
BDBM199210
PNG
(US9216998, 14)
Show SMILES FC(F)(F)c1c(CCc2ccccc2)n2CCN(Cc3cccc1c23)C(=O)Nc1ccccc1
Show InChI InChI=1S/C27H24F3N3O/c28-27(29,30)24-22-13-7-10-20-18-32(26(34)31-21-11-5-2-6-12-21)16-17-33(25(20)22)23(24)15-14-19-8-3-1-4-9-19/h1-13H,14-18H2,(H,31,34)
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...


US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM199210
PNG
(US9216998, 14)
Show SMILES FC(F)(F)c1c(CCc2ccccc2)n2CCN(Cc3cccc1c23)C(=O)Nc1ccccc1
Show InChI InChI=1S/C27H24F3N3O/c28-27(29,30)24-22-13-7-10-20-18-32(26(34)31-21-11-5-2-6-12-21)16-17-33(25(20)22)23(24)15-14-19-8-3-1-4-9-19/h1-13H,14-18H2,(H,31,34)
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...


US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM199220
PNG
(US9216998, 1)
Show SMILES FC(F)(F)c1c(CCCc2ccccc2)n2CCc3cccc1c23
Show InChI InChI=1S/C20H18F3N/c21-20(22,23)18-16-10-5-9-15-12-13-24(19(15)16)17(18)11-4-8-14-6-2-1-3-7-14/h1-3,5-7,9-10H,4,8,11-13H2
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...


US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM199218
PNG
(US9216998, 24)
Show SMILES CS(=O)(=O)N1CCn2c(CCc3ccccc3)c(c3cccc(C1)c23)C(F)(F)F
Show InChI InChI=1S/C21H21F3N2O2S/c1-29(27,28)25-12-13-26-18(11-10-15-6-3-2-4-7-15)19(21(22,23)24)17-9-5-8-16(14-25)20(17)26/h2-9H,10-14H2,1H3
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...


US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))
BDBM199220
PNG
(US9216998, 1)
Show SMILES FC(F)(F)c1c(CCCc2ccccc2)n2CCc3cccc1c23
Show InChI InChI=1S/C20H18F3N/c21-20(22,23)18-16-10-5-9-15-12-13-24(19(15)16)17(18)11-4-8-14-6-2-1-3-7-14/h1-3,5-7,9-10H,4,8,11-13H2
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...


US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))
BDBM199222
PNG
(US9216998, 4)
Show SMILES FC(F)(F)c1c(CCCc2ccccc2)n2CCCc3cccc1c23
Show InChI InChI=1S/C21H20F3N/c22-21(23,24)19-17-12-5-10-16-11-6-14-25(20(16)17)18(19)13-4-9-15-7-2-1-3-8-15/h1-3,5,7-8,10,12H,4,6,9,11,13-14H2
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...


US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))
BDBM199215
PNG
(US9216998, 21)
Show SMILES FC(F)(F)CC(=O)N1CCn2c(CCc3ccccc3)c(c3cccc(C1)c23)C(F)(F)F
Show InChI InChI=1S/C23H20F6N2O/c24-22(25,26)13-19(32)30-11-12-31-18(10-9-15-5-2-1-3-6-15)20(23(27,28)29)17-8-4-7-16(14-30)21(17)31/h1-8H,9-14H2
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...


US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM199215
PNG
(US9216998, 21)
Show SMILES FC(F)(F)CC(=O)N1CCn2c(CCc3ccccc3)c(c3cccc(C1)c23)C(F)(F)F
Show InChI InChI=1S/C23H20F6N2O/c24-22(25,26)13-19(32)30-11-12-31-18(10-9-15-5-2-1-3-6-15)20(23(27,28)29)17-8-4-7-16(14-30)21(17)31/h1-8H,9-14H2
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...


US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM199217
PNG
(US9216998, 23)
Show SMILES OCCN1CCn2c(CCc3ccccc3)c(c3cccc(C1)c23)C(F)(F)F
Show InChI InChI=1S/C22H23F3N2O/c23-22(24,25)20-18-8-4-7-17-15-26(13-14-28)11-12-27(21(17)18)19(20)10-9-16-5-2-1-3-6-16/h1-8,28H,9-15H2
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...


US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))
BDBM199218
PNG
(US9216998, 24)
Show SMILES CS(=O)(=O)N1CCn2c(CCc3ccccc3)c(c3cccc(C1)c23)C(F)(F)F
Show InChI InChI=1S/C21H21F3N2O2S/c1-29(27,28)25-12-13-26-18(11-10-15-6-3-2-4-7-15)19(21(22,23)24)17-9-5-8-16(14-25)20(17)26/h2-9H,10-14H2,1H3
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...


US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))
BDBM199217
PNG
(US9216998, 23)
Show SMILES OCCN1CCn2c(CCc3ccccc3)c(c3cccc(C1)c23)C(F)(F)F
Show InChI InChI=1S/C22H23F3N2O/c23-22(24,25)20-18-8-4-7-17-15-26(13-14-28)11-12-27(21(17)18)19(20)10-9-16-5-2-1-3-6-16/h1-8,28H,9-15H2
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...


US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM199227
PNG
(US9216998, 11)
Show SMILES FC(F)(F)c1c(CCCc2ccccc2)n2CCCCc3cccc1c23
Show InChI InChI=1S/C22H22F3N/c23-22(24,25)20-18-13-7-12-17-11-4-5-15-26(21(17)18)19(20)14-6-10-16-8-2-1-3-9-16/h1-3,7-9,12-13H,4-6,10-11,14-15H2
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...


US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM199228
PNG
(US9216998, 26)
Show SMILES FC(F)(F)c1c(CCCc2ccccc2)n2CCOc3cccc1c23
Show InChI InChI=1S/C20H18F3NO/c21-20(22,23)18-15-9-5-11-17-19(15)24(12-13-25-17)16(18)10-4-8-14-6-2-1-3-7-14/h1-3,5-7,9,11H,4,8,10,12-13H2
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...


US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM199214
PNG
(US9216998, 20)
Show SMILES CC(=O)OCC(=O)N1CCn2c(CCc3ccccc3)c(c3cccc(C1)c23)C(F)(F)F
Show InChI InChI=1S/C24H23F3N2O3/c1-16(30)32-15-21(31)28-12-13-29-20(11-10-17-6-3-2-4-7-17)22(24(25,26)27)19-9-5-8-18(14-28)23(19)29/h2-9H,10-15H2,1H3
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...


US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))
BDBM199214
PNG
(US9216998, 20)
Show SMILES CC(=O)OCC(=O)N1CCn2c(CCc3ccccc3)c(c3cccc(C1)c23)C(F)(F)F
Show InChI InChI=1S/C24H23F3N2O3/c1-16(30)32-15-21(31)28-12-13-29-20(11-10-17-6-3-2-4-7-17)22(24(25,26)27)19-9-5-8-18(14-28)23(19)29/h2-9H,10-15H2,1H3
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...


US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))
BDBM199228
PNG
(US9216998, 26)
Show SMILES FC(F)(F)c1c(CCCc2ccccc2)n2CCOc3cccc1c23
Show InChI InChI=1S/C20H18F3NO/c21-20(22,23)18-15-9-5-11-17-19(15)24(12-13-25-17)16(18)10-4-8-14-6-2-1-3-7-14/h1-3,5-7,9,11H,4,8,10,12-13H2
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...


US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))
BDBM199206
PNG
(US9216998, 15)
Show SMILES FC(F)(F)c1c(CCc2ccccc2)n2CCNCc3cccc1c23
Show InChI InChI=1S/C20H19F3N2/c21-20(22,23)18-16-8-4-7-15-13-24-11-12-25(19(15)16)17(18)10-9-14-5-2-1-3-6-14/h1-8,24H,9-13H2
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...


US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM199206
PNG
(US9216998, 15)
Show SMILES FC(F)(F)c1c(CCc2ccccc2)n2CCNCc3cccc1c23
Show InChI InChI=1S/C20H19F3N2/c21-20(22,23)18-16-8-4-7-15-13-24-11-12-25(19(15)16)17(18)10-9-14-5-2-1-3-6-14/h1-8,24H,9-13H2
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 694n/an/an/an/a7.2n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...


US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM199211
PNG
(US9216998, 16)
Show SMILES CN(C)CC(=O)N1CCn2c(CCc3ccccc3)c(c3cccc(C1)c23)C(F)(F)F
Show InChI InChI=1S/C24H26F3N3O/c1-28(2)16-21(31)29-13-14-30-20(12-11-17-7-4-3-5-8-17)22(24(25,26)27)19-10-6-9-18(15-29)23(19)30/h3-10H,11-16H2,1-2H3
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 959n/an/an/an/a7.2n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...


US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))
BDBM199211
PNG
(US9216998, 16)
Show SMILES CN(C)CC(=O)N1CCn2c(CCc3ccccc3)c(c3cccc(C1)c23)C(F)(F)F
Show InChI InChI=1S/C24H26F3N3O/c1-28(2)16-21(31)29-13-14-30-20(12-11-17-7-4-3-5-8-17)22(24(25,26)27)19-10-6-9-18(15-29)23(19)30/h3-10H,11-16H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.00E+3n/an/an/an/a7.2n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...


US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))
BDBM199227
PNG
(US9216998, 11)
Show SMILES FC(F)(F)c1c(CCCc2ccccc2)n2CCCCc3cccc1c23
Show InChI InChI=1S/C22H22F3N/c23-22(24,25)20-18-13-7-12-17-11-4-5-15-26(21(17)18)19(20)14-6-10-16-8-2-1-3-9-16/h1-3,7-9,12-13H,4-6,10-11,14-15H2
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.20E+3n/an/an/an/a7.2n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...


US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
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