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PubMed code 22910039

Compile data set for download or QSAR
Found 66 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50390916
PNG
(CHEMBL2070953)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2ccc(C)cc2)n1 |r|
Show InChI InChI=1S/C23H25N3O4S2/c1-16-6-12-19(13-7-16)32(28,29)26-14-4-3-5-21(26)22(27)25-23-24-20(15-31-23)17-8-10-18(30-2)11-9-17/h6-13,15,21H,3-5,14H2,1-2H3,(H,24,25,27)/t21-/m1/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of human ERG expressed in CHO cells after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390870
PNG
(CHEMBL2070962)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2ccc3OCOc3c2)n1 |r|
Show InChI InChI=1S/C23H23N3O6S2/c1-30-16-7-5-15(6-8-16)18-13-33-23(24-18)25-22(27)19-4-2-3-11-26(19)34(28,29)17-9-10-20-21(12-17)32-14-31-20/h5-10,12-13,19H,2-4,11,14H2,1H3,(H,24,25,27)/t19-/m1/s1
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n/an/an/an/a 780n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390883
PNG
(CHEMBL2070975)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)Cc2ccccc2Cl)n1 |r|
Show InChI InChI=1S/C23H24ClN3O4S2/c1-31-18-11-9-16(10-12-18)20-14-32-23(25-20)26-22(28)21-8-4-5-13-27(21)33(29,30)15-17-6-2-3-7-19(17)24/h2-3,6-7,9-12,14,21H,4-5,8,13,15H2,1H3,(H,25,26,28)/t21-/m1/s1
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390884
PNG
(CHEMBL2070976)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)Cc2ccc(Cl)cc2)n1 |r|
Show InChI InChI=1S/C23H24ClN3O4S2/c1-31-19-11-7-17(8-12-19)20-14-32-23(25-20)26-22(28)21-4-2-3-13-27(21)33(29,30)15-16-5-9-18(24)10-6-16/h5-12,14,21H,2-4,13,15H2,1H3,(H,25,26,28)/t21-/m1/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390887
PNG
(CHEMBL2070979)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2cn(C)cn2)n1 |r|
Show InChI InChI=1S/C20H23N5O4S2/c1-24-11-18(21-13-24)31(27,28)25-10-4-3-5-17(25)19(26)23-20-22-16(12-30-20)14-6-8-15(29-2)9-7-14/h6-9,11-13,17H,3-5,10H2,1-2H3,(H,22,23,26)/t17-/m1/s1
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390891
PNG
(CHEMBL2070984)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)C2CCCCCN2S(=O)(=O)c2ccc(C)cc2)n1
Show InChI InChI=1S/C24H27N3O4S2/c1-17-7-13-20(14-8-17)33(29,30)27-15-5-3-4-6-22(27)23(28)26-24-25-21(16-32-24)18-9-11-19(31-2)12-10-18/h7-14,16,22H,3-6,15H2,1-2H3,(H,25,26,28)
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390907
PNG
(CHEMBL2071002)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N1CCCC[C@@H]1C(=O)Nc1nccs1 |r|
Show InChI InChI=1S/C16H19N3O3S2/c1-12-5-7-13(8-6-12)24(21,22)19-10-3-2-4-14(19)15(20)18-16-17-9-11-23-16/h5-9,11,14H,2-4,10H2,1H3,(H,17,18,20)/t14-/m1/s1
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390916
PNG
(CHEMBL2070953)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2ccc(C)cc2)n1 |r|
Show InChI InChI=1S/C23H25N3O4S2/c1-16-6-12-19(13-7-16)32(28,29)26-14-4-3-5-21(26)22(27)25-23-24-20(15-31-23)17-8-10-18(30-2)11-9-17/h6-13,15,21H,3-5,14H2,1-2H3,(H,24,25,27)/t21-/m1/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of KCNQ2 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay relative to c...


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390919
PNG
(CHEMBL2070831)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccccc2)n1 |r|
Show InChI InChI=1S/C22H23N3O4S2/c1-29-17-12-10-16(11-13-17)19-15-30-22(23-19)24-21(26)20-9-5-6-14-25(20)31(27,28)18-7-3-2-4-8-18/h2-4,7-8,10-13,15,20H,5-6,9,14H2,1H3,(H,23,24,26)/t20-/m0/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390927
PNG
(CHEMBL2071000)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N1CCCC[C@@H]1C(=O)Nc1nc(cs1)-c1ccc(cc1)[N+]([O-])=O |r|
Show InChI InChI=1S/C22H22N4O5S2/c1-15-5-11-18(12-6-15)33(30,31)25-13-3-2-4-20(25)21(27)24-22-23-19(14-32-22)16-7-9-17(10-8-16)26(28)29/h5-12,14,20H,2-4,13H2,1H3,(H,23,24,27)/t20-/m1/s1
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390888
PNG
(CHEMBL2070980)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2cccnc2C)n1 |r|
Show InChI InChI=1S/C22H24N4O4S2/c1-15-20(7-5-12-23-15)32(28,29)26-13-4-3-6-19(26)21(27)25-22-24-18(14-31-22)16-8-10-17(30-2)11-9-16/h5,7-12,14,19H,3-4,6,13H2,1-2H3,(H,24,25,27)/t19-/m1/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390920
PNG
(CHEMBL2070832)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2ccccc2C)n1 |r|
Show InChI InChI=1S/C23H25N3O4S2/c1-16-7-3-4-9-21(16)32(28,29)26-14-6-5-8-20(26)22(27)25-23-24-19(15-31-23)17-10-12-18(30-2)13-11-17/h3-4,7,9-13,15,20H,5-6,8,14H2,1-2H3,(H,24,25,27)/t20-/m1/s1
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n/an/an/an/a 1.38E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390925
PNG
(CHEMBL2070957)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2ccccc2C(F)(F)F)n1 |r|
Show InChI InChI=1S/C23H22F3N3O4S2/c1-33-16-11-9-15(10-12-16)18-14-34-22(27-18)28-21(30)19-7-4-5-13-29(19)35(31,32)20-8-3-2-6-17(20)23(24,25)26/h2-3,6,8-12,14,19H,4-5,7,13H2,1H3,(H,27,28,30)/t19-/m1/s1
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n/an/an/an/a 4.74E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390873
PNG
(CHEMBL2070965)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2ccc(cc2)C#N)n1 |r|
Show InChI InChI=1S/C23H22N4O4S2/c1-31-18-9-7-17(8-10-18)20-15-32-23(25-20)26-22(28)21-4-2-3-13-27(21)33(29,30)19-11-5-16(14-24)6-12-19/h5-12,15,21H,2-4,13H2,1H3,(H,25,26,28)/t21-/m1/s1
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n/an/an/an/a 1.63E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390877
PNG
(CHEMBL2070969)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2cccc(Cl)c2)n1 |r|
Show InChI InChI=1S/C22H22ClN3O4S2/c1-30-17-10-8-15(9-11-17)19-14-31-22(24-19)25-21(27)20-7-2-3-12-26(20)32(28,29)18-6-4-5-16(23)13-18/h4-6,8-11,13-14,20H,2-3,7,12H2,1H3,(H,24,25,27)/t20-/m1/s1
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n/an/an/an/a 1.41E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390880
PNG
(CHEMBL2070972)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2ccc(F)cc2Cl)n1 |r|
Show InChI InChI=1S/C22H21ClFN3O4S2/c1-31-16-8-5-14(6-9-16)18-13-32-22(25-18)26-21(28)19-4-2-3-11-27(19)33(29,30)20-10-7-15(24)12-17(20)23/h5-10,12-13,19H,2-4,11H2,1H3,(H,25,26,28)/t19-/m1/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390914
PNG
(CHEMBL2071009)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N1CCCC[C@@H]1C(=O)Nc1nnc(s1)-c1ccc2occc2c1 |r|
Show InChI InChI=1S/C23H22N4O4S2/c1-15-5-8-18(9-6-15)33(29,30)27-12-3-2-4-19(27)21(28)24-23-26-25-22(32-23)17-7-10-20-16(14-17)11-13-31-20/h5-11,13-14,19H,2-4,12H2,1H3,(H,24,26,28)/t19-/m1/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390917
PNG
(CHEMBL1352968)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)C2CCCCN2S(=O)(=O)c2ccccc2)n1
Show InChI InChI=1S/C22H23N3O4S2/c1-29-17-12-10-16(11-13-17)19-15-30-22(23-19)24-21(26)20-9-5-6-14-25(20)31(27,28)18-7-3-2-4-8-18/h2-4,7-8,10-13,15,20H,5-6,9,14H2,1H3,(H,23,24,26)
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n/an/an/an/a 1.69E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390921
PNG
(CHEMBL2070952)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2cccc(C)c2)n1 |r|
Show InChI InChI=1S/C23H25N3O4S2/c1-16-6-5-7-19(14-16)32(28,29)26-13-4-3-8-21(26)22(27)25-23-24-20(15-31-23)17-9-11-18(30-2)12-10-17/h5-7,9-12,14-15,21H,3-4,8,13H2,1-2H3,(H,24,25,27)/t21-/m1/s1
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n/an/an/an/a 890n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390928
PNG
(CHEMBL2070958)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2cccc(c2)C(F)(F)F)n1 |r|
Show InChI InChI=1S/C23H22F3N3O4S2/c1-33-17-10-8-15(9-11-17)19-14-34-22(27-19)28-21(30)20-7-2-3-12-29(20)35(31,32)18-6-4-5-16(13-18)23(24,25)26/h4-6,8-11,13-14,20H,2-3,7,12H2,1H3,(H,27,28,30)/t20-/m1/s1
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n/an/an/an/a 1.00E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390878
PNG
(CHEMBL2070970)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2ccc(Cl)cc2)n1 |r|
Show InChI InChI=1S/C22H22ClN3O4S2/c1-30-17-9-5-15(6-10-17)19-14-31-22(24-19)25-21(27)20-4-2-3-13-26(20)32(28,29)18-11-7-16(23)8-12-18/h5-12,14,20H,2-4,13H2,1H3,(H,24,25,27)/t20-/m1/s1
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n/an/an/an/a 420n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390899
PNG
(CHEMBL2070993)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H](NS(=O)(=O)c2ccc(C)cc2)C(C)(C)C)n1 |r|
Show InChI InChI=1S/C23H27N3O4S2/c1-15-6-12-18(13-7-15)32(28,29)26-20(23(2,3)4)21(27)25-22-24-19(14-31-22)16-8-10-17(30-5)11-9-16/h6-14,20,26H,1-5H3,(H,24,25,27)/t20-/m0/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390902
PNG
(CHEMBL2070996)
Show SMILES CC(C)c1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2ccc(C)cc2)n1 |r|
Show InChI InChI=1S/C25H29N3O3S2/c1-17(2)19-9-11-20(12-10-19)22-16-32-25(26-22)27-24(29)23-6-4-5-15-28(23)33(30,31)21-13-7-18(3)8-14-21/h7-14,16-17,23H,4-6,15H2,1-3H3,(H,26,27,29)/t23-/m1/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390903
PNG
(CHEMBL2070997)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N1CCCC[C@@H]1C(=O)Nc1nc(cs1)-c1ccccc1 |r|
Show InChI InChI=1S/C22H23N3O3S2/c1-16-10-12-18(13-11-16)30(27,28)25-14-6-5-9-20(25)21(26)24-22-23-19(15-29-22)17-7-3-2-4-8-17/h2-4,7-8,10-13,15,20H,5-6,9,14H2,1H3,(H,23,24,26)/t20-/m1/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390904
PNG
(CHEMBL2070998)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N1CCCC[C@@H]1C(=O)Nc1nc(cs1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C22H22FN3O3S2/c1-15-5-11-18(12-6-15)31(28,29)26-13-3-2-4-20(26)21(27)25-22-24-19(14-30-22)16-7-9-17(23)10-8-16/h5-12,14,20H,2-4,13H2,1H3,(H,24,25,27)/t20-/m1/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390913
PNG
(CHEMBL2071008)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N1CCCC[C@@H]1C(=O)Nc1ncc(s1)-c1ccc2occc2c1 |r|
Show InChI InChI=1S/C24H23N3O4S2/c1-16-5-8-19(9-6-16)33(29,30)27-12-3-2-4-20(27)23(28)26-24-25-15-22(32-24)18-7-10-21-17(14-18)11-13-31-21/h5-11,13-15,20H,2-4,12H2,1H3,(H,25,26,28)/t20-/m1/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390918
PNG
(CHEMBL2070830)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2ccccc2)n1 |r|
Show InChI InChI=1S/C22H23N3O4S2/c1-29-17-12-10-16(11-13-17)19-15-30-22(23-19)24-21(26)20-9-5-6-14-25(20)31(27,28)18-7-3-2-4-8-18/h2-4,7-8,10-13,15,20H,5-6,9,14H2,1H3,(H,23,24,26)/t20-/m1/s1
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n/an/an/an/a 1.47E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390926
PNG
(CHEMBL2070981)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2C(=O)c2cccc(F)c2)n1 |r|
Show InChI InChI=1S/C23H22FN3O3S/c1-30-18-10-8-15(9-11-18)19-14-31-23(25-19)26-21(28)20-7-2-3-12-27(20)22(29)16-5-4-6-17(24)13-16/h4-6,8-11,13-14,20H,2-3,7,12H2,1H3,(H,25,26,28)/t20-/m1/s1
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n/an/an/an/a 6.13E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390876
PNG
(CHEMBL2070968)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2ccccc2Cl)n1 |r|
Show InChI InChI=1S/C22H22ClN3O4S2/c1-30-16-11-9-15(10-12-16)18-14-31-22(24-18)25-21(27)19-7-4-5-13-26(19)32(28,29)20-8-3-2-6-17(20)23/h2-3,6,8-12,14,19H,4-5,7,13H2,1H3,(H,24,25,27)/t19-/m1/s1
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n/an/an/an/a 730n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390881
PNG
(CHEMBL2070973)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2cc(Cl)ccc2F)n1 |r|
Show InChI InChI=1S/C22H21ClFN3O4S2/c1-31-16-8-5-14(6-9-16)18-13-32-22(25-18)26-21(28)19-4-2-3-11-27(19)33(29,30)20-12-15(23)7-10-17(20)24/h5-10,12-13,19H,2-4,11H2,1H3,(H,25,26,28)/t19-/m1/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390890
PNG
(CHEMBL2070983)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2C(=O)c2ccccc2OC)n1 |r|
Show InChI InChI=1S/C24H25N3O4S/c1-30-17-12-10-16(11-13-17)19-15-32-24(25-19)26-22(28)20-8-5-6-14-27(20)23(29)18-7-3-4-9-21(18)31-2/h3-4,7,9-13,15,20H,5-6,8,14H2,1-2H3,(H,25,26,28)/t20-/m1/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390897
PNG
(CHEMBL2070990)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCN(C2)S(=O)(=O)c2ccc(C)cc2)n1 |r|
Show InChI InChI=1S/C23H25N3O4S2/c1-16-5-11-20(12-6-16)32(28,29)26-13-3-4-18(14-26)22(27)25-23-24-21(15-31-23)17-7-9-19(30-2)10-8-17/h5-12,15,18H,3-4,13-14H2,1-2H3,(H,24,25,27)/t18-/m0/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390900
PNG
(CHEMBL2070994)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H](NS(=O)(=O)c2ccc(C)cc2)C(C)C)n1 |r|
Show InChI InChI=1S/C22H25N3O4S2/c1-14(2)20(25-31(27,28)18-11-5-15(3)6-12-18)21(26)24-22-23-19(13-30-22)16-7-9-17(29-4)10-8-16/h5-14,20,25H,1-4H3,(H,23,24,26)/t20-/m1/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390909
PNG
(CHEMBL2071004)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N1CCCC[C@@H]1C(=O)Nc1nc(cs1)-c1ccc2occc2c1 |r|
Show InChI InChI=1S/C24H23N3O4S2/c1-16-5-8-19(9-6-16)33(29,30)27-12-3-2-4-21(27)23(28)26-24-25-20(15-32-24)17-7-10-22-18(14-17)11-13-31-22/h5-11,13-15,21H,2-4,12H2,1H3,(H,25,26,28)/t21-/m1/s1
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n/an/an/an/a 1.32E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390922
PNG
(CHEMBL2070954)
Show SMILES CCCc1ccc(cc1)S(=O)(=O)N1CCCC[C@@H]1C(=O)Nc1nc(cs1)-c1ccc(OC)cc1 |r|
Show InChI InChI=1S/C25H29N3O4S2/c1-3-6-18-8-14-21(15-9-18)34(30,31)28-16-5-4-7-23(28)24(29)27-25-26-22(17-33-25)19-10-12-20(32-2)13-11-19/h8-15,17,23H,3-7,16H2,1-2H3,(H,26,27,29)/t23-/m1/s1
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n/an/an/an/a 700n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390923
PNG
(CHEMBL2070955)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2ccc(cc2)C(C)C)n1 |r|
Show InChI InChI=1S/C25H29N3O4S2/c1-17(2)18-9-13-21(14-10-18)34(30,31)28-15-5-4-6-23(28)24(29)27-25-26-22(16-33-25)19-7-11-20(32-3)12-8-19/h7-14,16-17,23H,4-6,15H2,1-3H3,(H,26,27,29)/t23-/m1/s1
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n/an/an/an/a 2.59E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390869
PNG
(CHEMBL2070961)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2cccc(OC)c2)n1 |r|
Show InChI InChI=1S/C23H25N3O5S2/c1-30-17-11-9-16(10-12-17)20-15-32-23(24-20)25-22(27)21-8-3-4-13-26(21)33(28,29)19-7-5-6-18(14-19)31-2/h5-7,9-12,14-15,21H,3-4,8,13H2,1-2H3,(H,24,25,27)/t21-/m1/s1
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n/an/an/an/a 810n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390882
PNG
(CHEMBL2070974)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2cccc(F)c2C)n1 |r|
Show InChI InChI=1S/C23H24FN3O4S2/c1-15-18(24)6-5-8-21(15)33(29,30)27-13-4-3-7-20(27)22(28)26-23-25-19(14-32-23)16-9-11-17(31-2)12-10-16/h5-6,8-12,14,20H,3-4,7,13H2,1-2H3,(H,25,26,28)/t20-/m1/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390885
PNG
(CHEMBL2070977)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2nccc3ccccc23)n1 |r|
Show InChI InChI=1S/C25H24N4O4S2/c1-33-19-11-9-18(10-12-19)21-16-34-25(27-21)28-23(30)22-8-4-5-15-29(22)35(31,32)24-20-7-3-2-6-17(20)13-14-26-24/h2-3,6-7,9-14,16,22H,4-5,8,15H2,1H3,(H,27,28,30)/t22-/m1/s1
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n/an/an/an/a 7.97E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390893
PNG
(CHEMBL2070986)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)C2CCN2S(=O)(=O)c2ccc(C)cc2)n1
Show InChI InChI=1S/C21H21N3O4S2/c1-14-3-9-17(10-4-14)30(26,27)24-12-11-19(24)20(25)23-21-22-18(13-29-21)15-5-7-16(28-2)8-6-15/h3-10,13,19H,11-12H2,1-2H3,(H,22,23,25)
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390905
PNG
(CHEMBL2070999)
Show SMILES Cc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2ccc(C)cc2)n1 |r|
Show InChI InChI=1S/C23H25N3O3S2/c1-16-6-10-18(11-7-16)20-15-30-23(24-20)25-22(27)21-5-3-4-14-26(21)31(28,29)19-12-8-17(2)9-13-19/h6-13,15,21H,3-5,14H2,1-2H3,(H,24,25,27)/t21-/m1/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390912
PNG
(CHEMBL2071007)
Show SMILES COc1ccc(cc1)-c1nnc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2ccc(C)cc2)s1 |r|
Show InChI InChI=1S/C22H24N4O4S2/c1-15-6-12-18(13-7-15)32(28,29)26-14-4-3-5-19(26)20(27)23-22-25-24-21(31-22)16-8-10-17(30-2)11-9-16/h6-13,19H,3-5,14H2,1-2H3,(H,23,25,27)/t19-/m1/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390915
PNG
(CHEMBL2071010)
Show SMILES COc1ccc(cc1)-c1nnc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2ccc(Cl)cc2)s1 |r|
Show InChI InChI=1S/C21H21ClN4O4S2/c1-30-16-9-5-14(6-10-16)20-24-25-21(31-20)23-19(27)18-4-2-3-13-26(18)32(28,29)17-11-7-15(22)8-12-17/h5-12,18H,2-4,13H2,1H3,(H,23,25,27)/t18-/m1/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390916
PNG
(CHEMBL2070953)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2ccc(C)cc2)n1 |r|
Show InChI InChI=1S/C23H25N3O4S2/c1-16-6-12-19(13-7-16)32(28,29)26-14-4-3-5-21(26)22(27)25-23-24-20(15-31-23)17-8-10-18(30-2)11-9-17/h6-13,15,21H,3-5,14H2,1-2H3,(H,24,25,27)/t21-/m1/s1
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n/an/an/an/a 260n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390867
PNG
(CHEMBL2070959)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2ccc(cc2)C(F)(F)F)n1 |r|
Show InChI InChI=1S/C23H22F3N3O4S2/c1-33-17-9-5-15(6-10-17)19-14-34-22(27-19)28-21(30)20-4-2-3-13-29(20)35(31,32)18-11-7-16(8-12-18)23(24,25)26/h5-12,14,20H,2-4,13H2,1H3,(H,27,28,30)/t20-/m1/s1
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n/an/an/an/a 1.71E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390868
PNG
(CHEMBL2070960)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2ccccc2OC)n1 |r|
Show InChI InChI=1S/C23H25N3O5S2/c1-30-17-12-10-16(11-13-17)18-15-32-23(24-18)25-22(27)19-7-5-6-14-26(19)33(28,29)21-9-4-3-8-20(21)31-2/h3-4,8-13,15,19H,5-7,14H2,1-2H3,(H,24,25,27)/t19-/m1/s1
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n/an/an/an/a 1.78E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390872
PNG
(CHEMBL2070964)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2cccc(c2)C#N)n1 |r|
Show InChI InChI=1S/C23H22N4O4S2/c1-31-18-10-8-17(9-11-18)20-15-32-23(25-20)26-22(28)21-7-2-3-12-27(21)33(29,30)19-6-4-5-16(13-19)14-24/h4-6,8-11,13,15,21H,2-3,7,12H2,1H3,(H,25,26,28)/t21-/m1/s1
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n/an/an/an/a 880n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390874
PNG
(CHEMBL2070966)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2cccc(F)c2)n1 |r|
Show InChI InChI=1S/C22H22FN3O4S2/c1-30-17-10-8-15(9-11-17)19-14-31-22(24-19)25-21(27)20-7-2-3-12-26(20)32(28,29)18-6-4-5-16(23)13-18/h4-6,8-11,13-14,20H,2-3,7,12H2,1H3,(H,24,25,27)/t20-/m1/s1
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n/an/an/an/a 1.16E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390875
PNG
(CHEMBL2070967)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2ccc(F)cc2)n1 |r|
Show InChI InChI=1S/C22H22FN3O4S2/c1-30-17-9-5-15(6-10-17)19-14-31-22(24-19)25-21(27)20-4-2-3-13-26(20)32(28,29)18-11-7-16(23)8-12-18/h5-12,14,20H,2-4,13H2,1H3,(H,24,25,27)/t20-/m1/s1
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n/an/an/an/a 1.03E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390879
PNG
(CHEMBL2070971)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2cccc(Cl)c2Cl)n1 |r|
Show InChI InChI=1S/C22H21Cl2N3O4S2/c1-31-15-10-8-14(9-11-15)17-13-32-22(25-17)26-21(28)18-6-2-3-12-27(18)33(29,30)19-7-4-5-16(23)20(19)24/h4-5,7-11,13,18H,2-3,6,12H2,1H3,(H,25,26,28)/t18-/m1/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390889
PNG
(CHEMBL2070982)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2C(=O)c2ccccc2)n1 |r|
Show InChI InChI=1S/C23H23N3O3S/c1-29-18-12-10-16(11-13-18)19-15-30-23(24-19)25-21(27)20-9-5-6-14-26(20)22(28)17-7-3-2-4-8-17/h2-4,7-8,10-13,15,20H,5-6,9,14H2,1H3,(H,24,25,27)/t20-/m1/s1
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n/an/an/an/a 8.16E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390892
PNG
(CHEMBL2070985)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)C2CCCN2S(=O)(=O)c2ccc(C)cc2)n1
Show InChI InChI=1S/C22H23N3O4S2/c1-15-5-11-18(12-6-15)31(27,28)25-13-3-4-20(25)21(26)24-22-23-19(14-30-22)16-7-9-17(29-2)10-8-16/h5-12,14,20H,3-4,13H2,1-2H3,(H,23,24,26)
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n/an/an/an/a 2.86E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390894
PNG
(CHEMBL2070987)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)C2COCCN2S(=O)(=O)c2ccc(C)cc2)n1
Show InChI InChI=1S/C22H23N3O5S2/c1-15-3-9-18(10-4-15)32(27,28)25-11-12-30-13-20(25)21(26)24-22-23-19(14-31-22)16-5-7-17(29-2)8-6-16/h3-10,14,20H,11-13H2,1-2H3,(H,23,24,26)
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n/an/an/an/a 4.38E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390895
PNG
(CHEMBL2070988)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)C2CSCCN2S(=O)(=O)c2ccc(C)cc2)n1
Show InChI InChI=1S/C22H23N3O4S3/c1-15-3-9-18(10-4-15)32(27,28)25-11-12-30-14-20(25)21(26)24-22-23-19(13-31-22)16-5-7-17(29-2)8-6-16/h3-10,13,20H,11-12,14H2,1-2H3,(H,23,24,26)
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n/an/an/an/a 600n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390898
PNG
(CHEMBL2070992)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)CCNS(=O)(=O)c2ccc(C)cc2)n1
Show InChI InChI=1S/C20H21N3O4S2/c1-14-3-9-17(10-4-14)29(25,26)21-12-11-19(24)23-20-22-18(13-28-20)15-5-7-16(27-2)8-6-15/h3-10,13,21H,11-12H2,1-2H3,(H,22,23,24)
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390901
PNG
(CHEMBL2070995)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@@H](C)NS(=O)(=O)c2ccc(C)cc2)n1 |r|
Show InChI InChI=1S/C20H21N3O4S2/c1-13-4-10-17(11-5-13)29(25,26)23-14(2)19(24)22-20-21-18(12-28-20)15-6-8-16(27-3)9-7-15/h4-12,14,23H,1-3H3,(H,21,22,24)/t14-/m1/s1
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n/an/an/an/a 1.29E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390906
PNG
(CHEMBL2071001)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N1CCCC[C@@H]1C(=O)Nc1nc(cs1)-c1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C22H22ClN3O3S2/c1-15-5-11-18(12-6-15)31(28,29)26-13-3-2-4-20(26)21(27)25-22-24-19(14-30-22)16-7-9-17(23)10-8-16/h5-12,14,20H,2-4,13H2,1H3,(H,24,25,27)/t20-/m1/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390908
PNG
(CHEMBL2071003)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N1CCCC[C@@H]1C(=O)Nc1nc2ccccc2s1 |r|
Show InChI InChI=1S/C20H21N3O3S2/c1-14-9-11-15(12-10-14)28(25,26)23-13-5-4-7-17(23)19(24)22-20-21-16-6-2-3-8-18(16)27-20/h2-3,6,8-12,17H,4-5,7,13H2,1H3,(H,21,22,24)/t17-/m1/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390910
PNG
(CHEMBL2071005)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N1CCCC[C@@H]1C(=O)Nc1nc(cs1)-c1ccc(OC(F)(F)F)cc1 |r|
Show InChI InChI=1S/C23H22F3N3O4S2/c1-15-5-11-18(12-6-15)35(31,32)29-13-3-2-4-20(29)21(30)28-22-27-19(14-34-22)16-7-9-17(10-8-16)33-23(24,25)26/h5-12,14,20H,2-4,13H2,1H3,(H,27,28,30)/t20-/m1/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390916
PNG
(CHEMBL2070953)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2ccc(C)cc2)n1 |r|
Show InChI InChI=1S/C23H25N3O4S2/c1-16-6-12-19(13-7-16)32(28,29)26-14-4-3-5-21(26)22(27)25-23-24-20(15-31-23)17-8-10-18(30-2)11-9-17/h6-13,15,21H,3-5,14H2,1-2H3,(H,24,25,27)/t21-/m1/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of KCNQ4 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay relative to c...


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390871
PNG
(CHEMBL2070963)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2ccccc2C#N)n1 |r|
Show InChI InChI=1S/C23H22N4O4S2/c1-31-18-11-9-16(10-12-18)19-15-32-23(25-19)26-22(28)20-7-4-5-13-27(20)33(29,30)21-8-3-2-6-17(21)14-24/h2-3,6,8-12,15,20H,4-5,7,13H2,1H3,(H,25,26,28)/t20-/m1/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390886
PNG
(CHEMBL2070978)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2cccnc2)n1 |r|
Show InChI InChI=1S/C21H22N4O4S2/c1-29-16-9-7-15(8-10-16)18-14-30-21(23-18)24-20(26)19-6-2-3-12-25(19)31(27,28)17-5-4-11-22-13-17/h4-5,7-11,13-14,19H,2-3,6,12H2,1H3,(H,23,24,26)/t19-/m1/s1
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n/an/an/an/a 1.36E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390896
PNG
(CHEMBL2070989)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)C2CNCCN2S(=O)(=O)c2ccc(C)cc2)n1
Show InChI InChI=1S/C22H24N4O4S2/c1-15-3-9-18(10-4-15)32(28,29)26-12-11-23-13-20(26)21(27)25-22-24-19(14-31-22)16-5-7-17(30-2)8-6-16/h3-10,14,20,23H,11-13H2,1-2H3,(H,24,25,27)
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390897
PNG
(CHEMBL2070990)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCN(C2)S(=O)(=O)c2ccc(C)cc2)n1 |r|
Show InChI InChI=1S/C23H25N3O4S2/c1-16-5-11-20(12-6-16)32(28,29)26-13-3-4-18(14-26)22(27)25-23-24-21(15-31-23)17-7-9-19(30-2)10-8-17/h5-12,15,18H,3-4,13-14H2,1-2H3,(H,24,25,27)/t18-/m0/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390911
PNG
(CHEMBL2071006)
Show SMILES COc1ccc(cc1)-c1cnc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2ccc(C)cc2)s1 |r|
Show InChI InChI=1S/C23H25N3O4S2/c1-16-6-12-19(13-7-16)32(28,29)26-14-4-3-5-20(26)22(27)25-23-24-15-21(31-23)17-8-10-18(30-2)11-9-17/h6-13,15,20H,3-5,14H2,1-2H3,(H,24,25,27)/t20-/m1/s1
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n/an/an/an/a 2.74E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390924
PNG
(CHEMBL2070956)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2ccc(cc2)C(C)(C)C)n1 |r|
Show InChI InChI=1S/C26H31N3O4S2/c1-26(2,3)19-10-14-21(15-11-19)35(31,32)29-16-6-5-7-23(29)24(30)28-25-27-22(17-34-25)18-8-12-20(33-4)13-9-18/h8-15,17,23H,5-7,16H2,1-4H3,(H,27,28,30)/t23-/m1/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%