360 articles for thisTarget

---

The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
28319392	216	Scaffold Repurposing of Nucleosides (Adenosine Receptor Agonists): Enhanced Activity at the Human Dopamine and Norepinephrine Sodium Symporters.	National Institute Of Diabetes And Digestive And Kidney Diseases
28244748	119	The 2014 Philip S. Portoghese Medicinal Chemistry Lectureship: The"Phenylalkylaminome" with a Focus on Selected Drugs of Abuse.	Virginia Commonwealth University
28274674	93	Design, synthesis and in vitro activity of 1,4-disubstituted piperazines and piperidines as triple reuptake inhibitors.	Chonnam National University
28089699	63	Investigation of piperazine benzamides as humanß	Merck
28041833	52	X-ray structure based evaluation of analogs of citalopram: Compounds with increased affinity and selectivity compared with R-citalopram for the allosteric site (S2) on hSERT.	3D-2Drug
27876250	60	Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH	Jagiellonian University Medical College
27939174	84	Challenges in the development of an M	Vanderbilt University Medical Center
27865645	62	Discovery of SMP-304, a novel benzylpiperidine derivative with serotonin transporter inhibitory activity and 5-HT	Sumitomo Dainippon Pharma
27537923	31	Novel bis-arylalkylamines as myeloperoxidase inhibitors: Design, synthesis, and structure-activity relationship study.	Universit£
27839919	192	Decahydrobenzoquinolin-5-one sigma receptor ligands: Divergent development of both sigma 1 and sigma 2 receptor selective examples.	University Of Kansas
27280968	6	Polycyclic Polyprenylated Acylphloroglucinol Congeners from Hypericum scabrum.	Chinese Academy Of Medical Sciences And Peking Union Medical College
27364609	230	Development of CNS multi-receptor ligands: Modification of known D2 pharmacophores.	Florida A&M University
27325446	42	Design, synthesis, and biological evaluation of a novel series of peripheral-selective noradrenaline reuptake inhibitors - Part 3.	Takeda Pharmaceutical
27312422	219	Design and synthesis of dual 5-HT1A and 5-HT7 receptor ligands.	Florida A&M University
27160055	76	Synthesis and inhibitory evaluation of 3-linked imipramines for the exploration of the S2 site of the human serotonin transporter.	Aarhus University
27041397	24	Design, synthesis, and biological evaluation of arylpiperazine-benzylpiperidines with dual serotonin and norepinephrine reuptake inhibitory activities.	Chonnam National University
26988801	55	Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.	Jagiellonian University Medical College
26935940	23	Emerging targets and new small molecule therapies in Parkinson's disease treatment.	School Of Medicine Of University Of Electronic Science And Technology Of China
26704965	229	Further Advances in Optimizing (2-Phenylcyclopropyl)methylamines as Novel Serotonin 2C Agonists: Effects on Hyperlocomotion, Prepulse Inhibition, and Cognition Models.	University Of Illinois At Chicago
26709102	142	Discovery of Vibegron: A Potent and Selectiveß3 Adrenergic Receptor Agonist for the Treatment of Overactive Bladder.	Merck Research Laboratories
26748694	44	The influence of 5-HT(2A) activity on a 5-HT(2C) specific in vivo assay used for early identification of multiple acting SERT and 5-HT(2C) receptor ligands.	Gedeon Richter
26739781	237	Receptor binding profiles and quantitative structure-affinity relationships of some 5-substituted-N,N-diallyltryptamines.	The Alexander Shulgin Research Institute
26372073	1	Reengineered tricyclic anti-cancer agents.	Icahn School Of Medicine At Mt. Sinai
26337019	22	Design and synthesis of 4-benzylpiperidine carboxamides as dual serotonin and norepinephrine reuptake inhibitors.	Chonnam National University
26233799	15	Ethylenedioxy homologs of N-methyl-(3,4-methylenedioxyphenyl)-2-aminopropane (MDMA) and its corresponding cathinone analog methylenedioxymethcathinone: Interactions with transporters for serotonin, dopamine, and norepinephrine.	Virginia Commonwealth University
25164761	41	Synthesis and pharmacological investigation of aralkyl diamine derivatives as potential triple reuptake inhibitors.	Shanghai Institute Of Pharmaceutical Industry
26051602	51	Design, synthesis and biological evaluation of a novel series of peripheral-selective noradrenaline reuptake inhibitor.	Takeda Pharmaceutical
26153715	4	Novel Azido-Iodo Photoaffinity Ligands for the Human Serotonin Transporter Based on the Selective Serotonin Reuptake Inhibitor (S)-Citalopram.	National Institute On Drug Abuse
25695425	62	Semisynthetic Studies on and Biological Evaluation of N-Methyllaurotetanine Analogues as Ligands for 5-HT Receptors.	City University Of New York
25557493	109	Novel 5-HT6 receptor antagonists/D2 receptor partial agonists targeting behavioral and psychological symptoms of dementia.	Jagiellonian University Collegium Medicum
25070422	126	Further evaluation of the tropane analogs of haloperidol.	Florida A&M University
25050161	112	Design and synthesis of 4-heteroaryl 1,2,3,4-tetrahydroisoquinolines as triple reuptake inhibitors.	Amri
25017029	39	Design, synthesis, and biological activities of 1-aryl-1,4-diazepan-2-one derivatives as novel triple reuptake inhibitors.	Takeda Pharmaceutical
24974340	90	Synthesis and biological evaluation of 3-phenethylazetidine derivatives as triple reuptake inhibitors.	Korea University
24881566	140	Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120).	Glaxosmithkline
25221656	116	Exploration of 3-Aminoazetidines as Triple Reuptake Inhibitors by Bioisosteric Modification of 3-a-Oxyazetidine.	Korea University
24944732	37	Hybrid dopamine uptake blocker-serotonin releaser ligands: a new twist on transporter-focused therapeutics.	Rti International
24944746	13	Novel and high affinity fluorescent ligands for the serotonin transporter based on (s)-citalopram.	National Institute On Drug Abuse-Intramural Research Program
24805037	380	Novel arylsulfonamide derivatives with 5-HT6/5-HT7 receptor antagonism targeting behavioral and psychological symptoms of dementia.	Adamed
24900826	22	Selective 5-HT Receptor Modulators May Deliver Focused Targeting with Fewer Adverse Effects.	Therachem Research Medilab (India)
24559051	141	Discovery of a tetracyclic quinoxaline derivative as a potent and orally active multifunctional drug candidate for the treatment of neuropsychiatric and neurological disorders.	Intra-Cellular Therapies
24187998	96	Design, synthesis, and biological evaluation of Erythrina alkaloid analogues as neuronal nicotinic acetylcholine receptor antagonists.	University Of Copenhagen
23581551	75	Design, synthesis, and structure-activity relationship studies of novel 3-alkylindole derivatives as selective and highly potent myeloperoxidase inhibitors.	Universit£
23477943	51	Discovery of disubstituted piperidines and homopiperidines as potent dual NK1 receptor antagonists-serotonin reuptake transporter inhibitors for the treatment of depression.	Bristol-Myers Squibb
23385211	6	Basic N-interlinked imipramines show apoptotic activity against malignant cells including Burkitt's lymphoma.	Trinity College
23253443	135	Design, optimization, and in vivo evaluation of a series of pyridine derivatives with dual NK1 antagonism and SERT inhibition for the treatment of depression.	Bristol-Myers Squibb Research And Development
23168018	10	A rhodamine-labeled citalopram analogue as a high-affinity fluorescent probe for the serotonin transporter.	National Institute On Drug Abuse-Intramural Research Program
24900562	126	Azepines and piperidines with dual norepinephrine dopamine uptake inhibition and antidepressant activity.	Astrazeneca
23265880	8	A new single-photon emission computed tomography (SPECT) imaging agent for serotonin transporters: [(125)I]Flip-IDAM, (2-((2-((dimethylamino)methyl)-4-iodophenyl)thio)phenyl)methanol.	University Of Pennsylvania
23061607	10	Organosilicon molecules with medicinal applications.	University Of California Davis
20951584	105	5-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}-2(1H)-quinolinones and 3,4-dihydro-2(1H)-quinolinones: dual-acting 5-HT1 receptor antagonists and serotonin reuptake inhibitors. Part 3.	Glaxosmithkline
19592243	66	Novel, achiral aminoheterocycles as selective monoamine reuptake inhibitors.	Roche Palo Alto
19286377	101	8-[2-(4-Aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones: dual-acting 5-HT1 receptor antagonists and serotonin reuptake inhibitors--part II.	Glaxosmithkline
18799312	84	6-[2-(4-Aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones: dual-acting 5-HT1 receptor antagonists and serotonin reuptake inhibitors.	Glaxosmithkline
18433113	124	Discovery of potent, orally bioavailable, selective 5-HT1A/B/D receptor antagonists.	Glaxosmithkline
15745809	15	Homotryptamines as potent and selective serotonin reuptake inhibitors (SSRIs).	Bristol-Myers Squibb Pharmaceutical Research Institute
12657274	109	Synthesis and SAR of aminoalkoxy-biaryl-4-carboxamides: novel and selective histamine H3 receptor antagonists.	Abbott Laboratories
23084899	102	4-Phenyl tetrahydroisoquinolines as dual norepinephrine and dopamine reuptake inhibitors.	Amri
23043306	69	Systematic in vivo screening of a series of 1-propyl-4-arylpiperidines against dopaminergic and serotonergic properties in rat brain: a scaffold-jumping approach.	Neurosearch Sweden
22959245	175	As(1) receptor pharmacophore derived from a series of N-substituted 4-azahexacyclo[5.4.1.0(2,6).0(3,10).0(5,9).0(8,11)]dodecan-3-ols (AHDs).	The University Of Sydney
22082561	9	Characterisation of [¹¹C]PR04.MZ in Papio anubis baboon: a selective high-affinity radioligand for quantitative imaging of the dopamine transporter.	Johannes Gutenberg University
21486038	177	Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder.	H. Lundbeck
21413808	170	Synopsis of some recent tactical application of bioisosteres in drug design.	Bristol-Myers Squibb Pharmaceutical Research And Development
23006002	35	Design, synthesis, and pharmacological evaluation of piperidin-4-yl amino aryl sulfonamides: novel, potent, selective, orally active, and brain penetrant 5-HT6 receptor antagonists.	Suven Life Sciences
22224640	53	Update on the development of antagonists of chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2). From lead optimization to clinical proof-of-concept in asthma and allergic rhinitis.	Oxagen
22938049	29	Exploration of novel 3-substituted azetidine derivatives as triple reuptake inhibitors.	Korea Institute Of Science And Technology
22608762	25	Synthesis and antidepressant activity of arylalkanol-piperidine derivatives as triple reuptake inhibitors.	Shanghai Institute Of Pharmaceutical Industry
22520153	135	Benzothiazoles as probes for the 5HT1A receptor and the serotonin transporter (SERT): a search for new dual-acting agents as potential antidepressants.	Florida A&M University
22607684	50	7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (s2) receptor ligands.	The University Of Sydney
22542010	31	Discovery of a novel melanin concentrating hormone receptor 1 (MCHR1) antagonist with reduced hERG inhibition.	Amgen
22313242	146	2-(Pyrrolidin-1-yl)ethyl-3,4-dihydroisoquinolin-1(2H)-one derivatives as potent and selective histamine-3 receptor antagonists.	Pfizer
22313227	78	Radiosynthesis and evaluation of an (18)F-labeled positron emission tomography (PET) radioligand for brain histamine subtype-3 receptors based on a nonimidazole 2-aminoethylbenzofuran chemotype.	National Institute Of Mental Health
22398259	87	Synthesis and structure-activity relationship studies of 3-biaryl-8-oxabicyclo[3.2.1]octane-2-carboxylic acid methyl esters.	Tubitak Mam Chemistry Institute P K 21 Gebze
21927645	1	NO-SSRIs: Nitric Oxide Chimera Drugs Incorporating a Selective Serotonin Reuptake Inhibitor.	TBA
21859078	62	Combination of two pharmacophoric systems: synthesis and pharmacological evaluation of spirocyclic pyranopyrazoles with highs1 receptor affinity.	Institut F£R Pharmazeutische Und Medizinische Chemie Der Universit£T M£Nster
21726069	98	Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators.	University Of Namur
21058665	52	Nicotinic Acetylcholine Receptor Efficacy and Pharmacological Properties of 3-(Substituted phenyl)-2ß-substituted Tropanes.	Research Triangle Institute
21207959	69	Syntheses of 2-amino and 2-halothiazole derivatives as high-affinity metabotropic glutamate receptor subtype 5 ligands and potential radioligands for in vivo imaging.	National Institute Of Mental Health
20875743	90	Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: design, synthesis, and structure-activity rela	Pfizer
20684563	176	Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 receptor agonist with unprecedented selectivity and procognitive potential.	H. Lundbeck
20724153	31	Synthesis and pharmacological evaluation of 3-aryl-3-azolylpropan-1-amines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors.	Korea Institute Of Science And Technology
20597489	17	Synthesis, fluorine-18 radiolabeling, and biological evaluation of N-((E)-4-fluorobut-2-en-1-yl)-2beta-carbomethoxy-3beta-(4'-halophenyl)nortropanes: candidate radioligands for in vivo imaging of the brain dopamine transporter with positron emission tomography.	Emory University
20471260	146	Second generation N-(1,2-diphenylethyl)piperazines as dual serotonin and noradrenaline reuptake inhibitors: improving metabolic stability and reducing ion channel activity.	Pfizer
20153188	44	Structure-activity relationships of norepinephrine reuptake inhibitors with benzothiadiazine dioxide or dihydrosulfostyril cores.	Pfizer
19963380	38	Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine.	Hunter College And The Graduate Center Of The City University Of New York
19740668	48	Inhibition of serotonin and norepinephrine reuptake and inhibition of phosphodiesterase by multi-target inhibitors as potential agents for depression.	Human Biomolecular Research Institute
19720528	54	Tetrahydrocarbazole-based serotonin reuptake inhibitor/dopamine D2 partial agonists for the potential treatment of schizophrenia.	Wyeth Research
19821575	47	Antagonists of the calcium receptor. 2. Amino alcohol-based parathyroid hormone secretagogues.	Glaxosmithkline
19523837	54	Synthesis and structure-activity relationship of 3beta-(4-alkylthio, -methylsulfinyl, and -methylsulfonylphenyl)tropane and 3beta-(4-alkylthiophenyl)nortropane derivatives for monoamine transporters.	Research Triangle Institute
19821577	178	Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for cocaine addiction.	Research Triangle Institute
19722525	31	1- or 3-(3-Amino-2-hydroxy-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones: potent, selective, and orally efficacious norepinephrine reuptake inhibitors.	Wyeth Research
19329313	50	3-(Arylamino)-3-phenylpropan-2-olamines as a new series of dual norepinephrine and serotonin reuptake inhibitors.	Wyeth Research
17846138	26	Design, synthesis, and evaluation of 10-N-substituted acridones as novel chemosensitizers in Plasmodium falciparum.	Veterans Affairs Medical Center
19201198	210	2,5-Disubstituted tetrahydrofurans as selective serotonin re-uptake inhibitors.	Human Biomolecular Research Institute
18954038	62	Characterization of thien-2-yl 1S,2R-milnacipran analogues as potent norepinephrine/serotonin transporter inhibitors for the treatment of neuropathic pain.	Neurocrine Biosciences
19159187	38	Indene-based scaffolds. 2. An indole-indene switch: discovery of novel indenylsulfonamides as 5-HT6 serotonin receptor agonists.	Universitat De Barcelona
18800760	96	Enantiomeric propanolamines as selective N-methyl-D-aspartate 2B receptor antagonists.	Emory University
19067522	18	Synthesis, radiosynthesis, and biological evaluation of carbon-11 and fluorine-18 labeled reboxetine analogues: potential positron emission tomography radioligands for in vivo imaging of the norepinephrine transporter.	Emory University
19014888	52	Stereoselective inhibition of serotonin re-uptake and phosphodiesterase by dual inhibitors as potential agents for depression.	Human Biomolecular Research Institute
18951020	34	Synthesis and activity of novel 1- or 3-(3-amino-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones as selective norepinephrine reuptake inhibitors.	Wyeth Research
18847250	37	Potential modes of interaction of 9-aminomethyl-9,10-dihydroanthracene (AMDA) derivatives with the 5-HT2A receptor: a ligand structure-affinity relationship, receptor mutagenesis and receptor modeling investigation.	Virginia Commonwealth University
18834188	232	Advances toward new antidepressants with dual serotonin transporter and 5-HT1A receptor affinity within a class of 3-aminochroman derivatives. Part 2.	Wyeth Research
18771916	37	Synthesis and activity of 1-(3-amino-1-phenylpropyl)indolin-2-ones: a new class of selective norepinephrine reuptake inhibitors.	Wyeth Research
18760923	37	Synthesis and biological affinity of new imidazo- and indol-arylpiperazine derivatives: further validation of a pharmacophore model for alpha(1)-adrenoceptor antagonists.	Universit£
18550369	82	Discovery of a potent, selective, and less flexible selective norepinephrine reuptake inhibitor (sNRI).	Neurocrine Biosciences
18539031	126	Studies on the structure-activity relationship of bicifadine analogs as monoamine transporter inhibitors.	Neurocrine Biosciences
18672364	119	Structure-activity relationships of chiral selective norepinephrine reuptake inhibitors (sNRI) with increased oxidative stability.	Neurocrine Biosciences
18556210	75	Synthesis and monoamine transporter binding properties of 2beta-[3'-(substituted benzyl)isoxazol-5-yl]- and 2beta-[3'-methyl-4'-(substituted phenyl)isoxazol-5-yl]-3beta-(substituted phenyl)tropanes.	Research Triangle Institute
18468904	48	High specific activity tritium-labeled N-(2-methoxybenzyl)-2,5-dimethoxy-4-iodophenethylamine (INBMeO): a high-affinity 5-HT2A receptor-selective agonist radioligand.	Purdue University
18434164	42	Synthesis and receptor binding properties of 2beta-alkynyl and 2beta-(1,2,3-triazol)substituted 3beta-(substituted phenyl)tropane derivatives.	Research Triangle Institute
18417343	62	Pyridyl-phenyl ether monoamine reuptake inhibitors: Impact of lipophilicity on dual SNRI pharmacology and off-target promiscuity.	Pfizer
18313294	68	[4-(Phenoxy)pyridin-3-yl]methylamines: a new class of selective noradrenaline reuptake inhibitors.	Pfizer
18221879	13	Synthesis and structure-affinity relationships of novel spirocyclic sigma receptor ligands with furopyrazole structure.	Westf£Lische Wilhelms-Universit£T M£Nster
18053732	26	The synthesis of bivalent 2beta-carbomethoxy-3beta-(3,4-dichlorophenyl)-8-heterobicyclo[3.2.1]octanes as probes for proximal binding sites on the dopamine and serotonin transporters.	Organix
18207394	126	Studies on the SAR and pharmacophore of milnacipran derivatives as monoamine transporter inhibitors.	Neurocrine Bioscience
18468895	102	Studies on a series of milnacipran analogs containing a heteroaromatic group as potent norepinephrine and serotonin transporter inhibitors.	Neurocrine Bioscience
18445525	141	Identification of 1S,2R-milnacipran analogs as potent norepinephrine and serotonin transporter inhibitors.	Neurocrine Bioscience
17983754	21	Synthesis, in vitro characterization, and radiolabeling of reboxetine analogs as potential PET radioligands for imaging the norepinephrine transporter.	Emory University
18242987	75	In vitro and in vivo evaluation of O-alkyl derivatives of tramadol.	Sepracor
18240382	104	1-(2-Phenoxyphenyl)methanamines: SAR for dual serotonin/noradrenaline reuptake inhibition, metabolic stability and hERG affinity.	Pfizer
18060777	158	Synthesis and biological activity of piperazine and diazepane amides that are histamine H3 antagonists and serotonin reuptake inhibitors.	Johnson & Johnson Pharmaceutical Research & Development
18181565	71	Multi-target-directed ligands to combat neurodegenerative diseases.	University Of Bologna
17766113	51	Conformationally restricted homotryptamines. Part 4: Heterocyclic and naphthyl analogs of a potent selective serotonin reuptake inhibitor.	Bristol-Myers Squibb Pharmaceutical Research Institute
17446076	187	Synthesis, inhibition and binding of simple non-nitrogen inhibitors of monoamine transporters.	University Of Aarhus
17407815	27	Tricyclic isoxazolines: identification of R226161 as a potential new antidepressant that combines potent serotonin reuptake inhibition and alpha2-adrenoceptor antagonism.	Janssen-Cilag
16279803	59	Synthesis and monoamine transporter binding properties of 2,3-diaryltropanes.	Research Triangle Institute
15566309	69	Monoamine transporter binding, locomotor activity, and drug discrimination properties of 3-(4-substituted-phenyl)tropane-2-carboxylic acid methyl ester isomers.	Research Triangle Institute
17228864	328	Slow-onset, long-duration, alkyl analogues of methylphenidate with enhanced selectivity for the dopamine transporter.	Massachusetts College Of Pharmacy And Health Sciences
16750359	58	N-(1,2-diphenylethyl)piperazines: a new class of dual serotonin/noradrenaline reuptake inhibitor.	Pfizer
16750363	101	Structure-activity relationships of N-substituted piperazine amine reuptake inhibitors.	Pfizer
16854086	96	Synthesis and biological evaluation of novel compounds within a class of 3-aminochroman derivatives with dual 5-HT1A receptor and serotonin transporter affinity.	Wyeth Research
16854064	65	Synthesis and monoamine transporter binding properties of 2,3-cyclo analogues of 3beta-(4'-aminophenyl)-2beta-tropanemethanol.	Research Triangle Institute
16480278	279	1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors.	Organix
16257206	18	Derivatives of tramadol for increased duration of effect.	Sepracor
16213721	60	N-8-Substituted benztropinamine analogs as selective dopamine transporter ligands.	National Institute On Drug Abuse-Intramural Research Program
16220969	219	Designed multiple ligands. An emerging drug discovery paradigm.	Organon Laboratories
16162005	30	Conformationally restricted homotryptamines. 2. Indole cyclopropylmethylamines as selective serotonin reuptake inhibitors.	Bristol-Myers Squibb Pharmaceutical Research Institute
15828826	17	Synthesis and pharmacology of ethylphenidate enantiomers: the human transesterification metabolite of methylphenidate and ethanol.	Medical University Of South Carolina
15546718	28	Synthesis of 8-thiabicyclo[3.2.1]oct-2-enes and their binding affinity for the dopamine and serotonin transporters.	Organix
12954071	109	A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole.	Alcon Research
12723940	145	2002 Medicinal Chemistry Division Award address: monoamine transporters and opioid receptors. Targets for addiction therapy.	Research Triangle Institute
12213053	117	Mazindol analogues as potential inhibitors of the cocaine binding site at the dopamine transporter.	Drew University
11472216	89	Synthesis of 6- and 7- hydroxy-8-azabicyclo[3.2.1]octanes and their binding affinity for the dopamine and serotonin transporters.	Organix
11150168	165	Slow-onset, long-duration 3-(3',4'-dichlorophenyl)-1-indanamine monoamine reuptake blockers as potential medications to treat cocaine abuse.	Pharm-Eco Laboratories
10649976	72	Novel 3-aminomethyl- and 4-aminopiperidine analogues of 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazines: synthesis and evaluation as dopamine transporter ligands.	Massachusetts General Hospital
10956207	43	2-Carbomethoxy-3-aryl-8-bicyclo[3.2.1]octanes: potent non-nitrogen inhibitors of monoamine transporters.	Organix
10821718	69	Novel conformationally constrained tropane analogues by 6-endo-trig radical cyclization and stille coupling - switch of activity toward the serotonin and/or norepinephrine transporter.	Georgetown University Medical Center
10479296	66	Design, synthesis, and biological evaluation of novel non-piperazine analogues of 1-[2-(diphenylmethoxy)ethyl]- and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines as dopamine transporter inhibitors.	Massachusetts General Hospital
9804682	12	TROTEC-1: a new high-affinity ligand for labeling of the dopamine transporter.	Institut F£R Bioanorganische Und Radiopharmazeutische Chemie
9276012	53	2-Carbomethoxy-3-aryl-8-oxabicyclo[3.2.1]octanes: potent non-nitrogen inhibitors of monoamine transporters.	Organix
8558504	43	2-Carbomethoxy-3-(diarylmethoxy)-1 alpha H, 5 alpha H-tropane analogs: synthesis and inhibition of binding at the dopamine transporter and comparison with piperazines of the GBR series.	Organix
8027983	16	The discovery of an unusually selective and novel cocaine analog: difluoropine. Synthesis and inhibition of binding at cocaine recognition sites.	Organix
8464040	21	Substituted 3-phenyltropane analogs of cocaine: synthesis, inhibition of binding at cocaine recognition sites, and positron emission tomography imaging.	Organix
7452682	76	3-(4-Piperidinylalkyl)indoles, selective inhibitors of neuronal 5-hydroxytryptamine uptake.	TBA
12565962	41	Pharmacophore-based discovery of substituted pyridines as novel dopamine transporter inhibitors.	University Of Michigan
14592523	42	Synthesis and biological activity of 2-carbomethoxy-3-catechol-8-azabicyclo[3.2.1]octanes.	Organix
12798324	36	Bivalent biogenic amine reuptake inhibitors.	Human Biomolecular Research Institute
10698458	26	Design, synthesis and biological evaluation of 7-azatricyclodecanes: analogues of cocaine.	Georgetown University Medical Center
10206550	28	Bicyclo[3.2.1]octanes: synthesis and inhibition of binding at the dopamine and serotonin transporters.	Organix
9871604	114	Synthesis of a potent wide-spectrum serotonin-, norepinephrine-, dopamine-reuptake inhibitor (SNDRI) and a species-selective dopamine-reuptake inhibitor based on the gamma-amino alcohol functional group.	Hong Kong University Of Science And Technology
	8	Synthesis and pharmacological characterization of A-80426: A putative novel antidepressant combining -2 antagonism with 5-HT uptake inhibition	TBA
22309909	37	Synthesis, in vitro binding studies and docking of long-chain arylpiperazine nitroquipazine analogues, as potential serotonin transporter inhibitors.	National Medicines Institute
22300887	8	QSAR study and synthesis of new phenyltropanes as ligands of the dopamine transporter (DAT).	University Of Tours
22123324	36	Discovery and characterization of a potent and selective antagonist of melanin-concentrating hormone receptor 2.	Amgen
22037049	62	Trace amine-associated receptor 1 is a stereoselective binding site for compounds in the amphetamine class.	Research Triangle Institute
21458259	29	Synthesis and evaluation of novel N-fluoropyridyl derivatives of tropane as potential PET imaging agents for the dopamine transporter.	Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)
21782428	61	Discovery of Lu AA33810: a highly selective and potent NPY5 antagonist with in vivo efficacy in a model of mood disorder.	Lundbeck Research Usa
21916421	68	Discovery of novel selective norepinephrine inhibitors: 1-(2-morpholin-2-ylethyl)-3-aryl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxides (WYE-114152).	Pfizer
21899931	27	Synthesis and pharmacological evaluation of indole-based sigma receptor ligands.	The University Of Mississippi
21823597	373	Design and synthesis of novel arylpiperazine derivatives containing the imidazole core targeting 5-HT(2A) receptor and 5-HT transporter.	Green Cross
21319801	54	Synthesis of 2-(substituted phenyl)-3,5,5-trimethylmorpholine analogues and their effects on monoamine uptake, nicotinic acetylcholine receptor function, and behavioral effects of nicotine.	Research Triangle Institute
21398123	56	The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS).	Astrazeneca Charnwood
21310612	99	Discovery of N-methyl-1-(1-phenylcyclohexyl)ethanamine, a novel triple serotonin, norepinephrine and dopamine reuptake inhibitor.	Sunovion Pharmaceuticals
21310609	108	Discovery of N-methyl-1-(1-phenylcyclohexyl)methanamine, a novel triple serotonin, norepinephrine, and dopamine reuptake inhibitor.	Sunovion Pharmaceuticals
21227702	9	Synthesis and serotonin transporter activity of 1,3-bis(aryl)-2-nitro-1-propenes as a new class of anticancer agents.	Trinity College
21095126	60	Discovery of 1-(3,4-dichlorophenyl)-N,N-dimethyl-1,2,3,4-tetrahydroquinolin-4-amine, a dual serotonin and dopamine reuptake inhibitor.	Sunovion Pharmaceuticals
21093273	154	Synthesis and pharmacological evaluation of 4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalenyl amines as triple reuptake inhibitors.	Sepracor
21146989	46	Trishomocubane as a scaffold for the development of selective dopamine transporter (DAT) ligands.	The University Of Sydney
21146984	58	The synthesis and biological evaluation of 2-(3-methyl or 3-phenylisoxazol-5-yl)-3-aryl-8-thiabicyclo[3.2.1]octanes.	Organix
21112782	80	The identification, and optimisation of hERG selectivity, of a mixed NET/SERT re-uptake inhibitor for the treatment of pain.	Msd
21185183	111	Design, synthesis, and pharmacological evaluation of azetedine and pyrrolidine derivatives as dual norepinephrine reuptake inhibitors and 5-HT(1A) partial agonists.	Pfizer
20949929	63	Conformationally restricted homotryptamines. Part 7: 3-cis-(3-aminocyclopentyl)indoles as potent selective serotonin reuptake inhibitors.	Bristol-Myers Squibb
20945906	33	Diaryldiamines with dual inhibition of the histamine H(3) receptor and the norepinephrine transporter and the efficacy of 4-(3-(methylamino)-1-phenylpropyl)-6-(2-(pyrrolidin-1-yl)ethoxy)naphthalen-1-ol in pain.	Abbott Laboratories
20933409	50	Arylpiperazine-containing pyrimidine 4-carboxamide derivatives targeting serotonin 5-HT(2A), 5-HT(2C), and the serotonin transporter as a potential antidepressant.	Green Cross
20812727	157	Synthesis, structure-affinity relationships, and radiolabeling of selective high-affinity 5-HT4 receptor ligands as prospective imaging probes for positron emission tomography.	National Institute Of Mental Health
20801650	245	6-Alkoxyisoindolin-1-one based dopamine D2 partial agonists as potential antipsychotics.	Pfizer
20813948	63	Spiroindolones, a potent compound class for the treatment of malaria.	Swiss Tropical And Public Health Institute
20692833	41	N-tetrahydrothiochromenoisoxazole-1-carboxamides as selective antagonists of cloned human 5-HT2B.	Csiro Molecular And Health Technologies
20637635	180	Further optimization of novel pyrrole 3-carboxamides for targeting serotonin 5-HT(2A), 5-HT(2C), and the serotonin transporter as a potential antidepressant.	Green Cross
20591666	66	A new group of oxime carbamates as reversible inhibitors of fatty acid amide hydrolase.	Università
20509659	182	Synthesis and characterization of in vitro and in vivo profiles of hydroxybupropion analogues: aids to smoking cessation.	Barrow Neurological Institute
20466553	6	Synthesis and in vitro toxicity of 4-MTA, its characteristic clandestine synthesis byproducts and related sulfur substituted alpha-alkylthioamphetamines.	Trinity College
20529687	3	Synthesis and in vivo evaluation of [11C]MPTQ: a potential PET tracer for alpha2A-adrenergic receptors.	Columbia University
20462211	92	Discovery of novel selective norepinephrine reuptake inhibitors: 4-[3-aryl-2,2-dioxido-2,1,3-benzothiadiazol-1(3H)-yl]-1-(methylamino)butan-2-ols (WYE-103231).	Pfizer
20378347	27	Heterocyclic cycloalkanol ethylamines as norepinephrine reuptake inhibitors.	Wyeth Research
20347298	28	Potent dihydroquinolinone dopamine D2 partial agonist/serotonin reuptake inhibitors for the treatment of schizophrenia.	Wyeth Research
20149649	133	Arylpiperazine-containing pyrrole 3-carboxamide derivatives targeting serotonin 5-HT(2A), 5-HT(2C), and the serotonin transporter as a potential antidepressant.	Green Cross
20137933	218	Identification of piperazine-bisamide GHSR antagonists for the treatment of obesity.	Amgen
19717215	56	Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents.	Trinity College
19647430	104	N-[(3S)-Pyrrolidin-3-yl]benzamides as novel dual serotonin and noradrenaline reuptake inhibitors: impact of small structural modifications on P-gp recognition and CNS penetration.	Pfizer
20034793	31	Synthesis and hSERT activity of homotryptamine analogs. Part 6: [3+2] dipolar cycloaddition of 3-vinylindoles.	Bristol-Myers Squibb
20031410	84	Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agonists.	Pfizer
19926484	26	Synthesis and in vitro evaluation of fluorinated diphenyloxide derivatives and sulfur analogs as serotonin transporter ligands.	University Of Tours
20158204	136	Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation.	Research Triangle Institute
20131864	59	1-(Indolin-1-yl)-1-phenyl-3-propan-2-olamines as potent and selective norepinephrine reuptake inhibitors.	Wyeth Research
19932965	80	Synthesis and structure-activity relationship of novel lactam-fused chroman derivatives having dual affinity at the 5-HT(1A) receptor and the serotonin transporter.	Wyeth Research
19646882	72	Novel delta opioid receptor agonists exhibit differential stimulation of signaling pathways.	University Of Medicine And Dentistry Of New Jersey-Robert Wood Johnson Medical School And The Informatics Institute Of Umdnj
19560930	69	An extended study of dimeric phenyl tropanes.	Aarhus University
19740658	73	Design and optimisation of selective serotonin re-uptake inhibitors with high synthetic accessibility: part 2.	Pfizer
19632110	29	Discovery of a new series of monoamine reuptake inhibitors, the 1-amino-3-(1H-indol-1-yl)-3-phenylpropan-2-ols.	Wyeth Research
19739674	39	Identification of novel indanylsulfonamide guanylhydrazones as potent 5-HT6 serotonin receptor antagonists.	Universitat De Barcelona
19713106	66	Structure-activity relationships of the 1-amino-3-(1H-indol-1-yl)-3-phenylpropan-2-ol series of monoamine reuptake inhibitors.	Wyeth Research
19854053	152	Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1A partial agonists.	Pfizer
19791802	21	Synthesis of 1,1-[1-naphthyloxy-2-thiophenyl]-2-methylaminomethylcyclopropanes and their evaluation as inhibitors of serotonin, norepinephrine, and dopamine transporters.	Oregon State University
19616432	176	Design, synthesis and evaluation of N-[(3S)-pyrrolidin-3-yl]benzamides as selective noradrenaline reuptake inhibitors: CNS penetration in a more polar template.	Pfizer
19596193	72	Design, synthesis and evaluation of a novel cyclohexanamine class of neuropeptide Y Y1 receptor antagonists.	Tsukuba Research Institute
19560923	20	Conformationally restricted homotryptamines. Part 5: 3-(trans-2-aminomethylcyclopentyl)indoles as potent selective serotonin reuptake inhibitors.	Bristol-Myers Squibb Pharmaceutical Research Institute
19719241	55	Synthesis, potency, and in vivo evaluation of 2-piperazin-1-ylquinoline analogues as dual serotonin reuptake inhibitors and serotonin 5-HT1A receptor antagonists.	Wyeth Research
19359175	132	4-Piperidines and 3-pyrrolidines as dual serotonin and noradrenaline reuptake inhibitors: design, synthesis and structure-activity relationships.	Pfizer
8496700	16	The Role of Receptor Binding in Drug Discovery	TBA
19492813	56	Antagonists of the calcium receptor I. Amino alcohol-based parathyroid hormone secretagogues.	Glaxosmithkline
19445453	87	Structure-activity relationships comparing N-(6-methylpyridin-yl)-substituted aryl amides to 2-methyl-6-(substituted-arylethynyl)pyridines or 2-methyl-4-(substituted-arylethynyl)thiazoles as novel metabotropic glutamate receptor subtype 5 antagonists.	National Institute On Drug Abuse-Intramural Research Program
19329329	183	Synthesis and in vitro affinities of various MDL 100907 derivatives as potential 18F-radioligands for 5-HT2A receptor imaging with PET.	Institute Of Nuclear Chemistry Johannes Gutenberg-University Mainz
19284718	191	Selective 5-hydroxytryptamine 2C receptor agonists derived from the lead compound tranylcypromine: identification of drugs with antidepressant-like action.	University Of Illinois At Chicago
19282174	85	Design and optimization of selective serotonin re-uptake inhibitors with high synthetic accessibility. Part 1.	Pfizer
19053782	18	Synthesis, radiosynthesis, and biological evaluation of fluorine-18-labeled 2beta-carbo(fluoroalkoxy)-3beta-(3'-((Z)-2-haloethenyl)phenyl)nortropanes: candidate radioligands for in vivo imaging of the serotonin transporter with positron emission tomography.	Emory University
19053748	57	Development of 3-phenyltropane analogues with high affinity for the dopamine and serotonin transporters and low affinity for the norepinephrine transporter.	Research Triangle Institute
18954985	111	Novel 3,3-disubstituted pyrrolidines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors.	Roche Palo Alto
18954981	108	Synthesis and structure-activity relationships of selective norepinephrine reuptake inhibitors (sNRI) with improved pharmaceutical characteristics.	Neurocrine Biosciences
18948001	179	Quantitative structure-activity relationship of phenoxyphenyl-methanamine compounds with 5HT2A, SERT, and hERG activities.	Pfizer
18783208	11	Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function.	National Institute Of Mental Health
18782666	34	Designing rapid onset selective serotonin re-uptake inhibitors. Part 3: Site-directed metabolism as a strategy to avoid active circulating metabolites: structure-activity relationships of (thioalkyl)phenoxy benzylamines.	Pfizer
18701276	97	Highly functionalized 7-azaindoles as selective PPAR gamma modulators.	Merck Research Laboratories
18667309	123	Synthesis and structure-activity relationships of selective norepinephrine reuptake inhibitors (sNRI) with a heterocyclic ring constraint.	Neurocrine Biosciences
18644726	36	3-(4-(6-Fluoroalkoxy-3,4-dihydroisoquinoline-2(1H)-yl)cyclohexyl)-1H-indole-5-carbonitriles for SERT imaging: chemical synthesis, evaluation in vitro and radiofluorination.	Institut FüR InterdisziplinäRe Isotopenforschung
18625557	60	N-Benzyl-N-(pyrrolidin-3-yl)carboxamides as a new class of selective dual serotonin/noradrenaline reuptake inhibitors.	Pfizer
18621528	133	Derivatives of (3S)-N-(biphenyl-2-ylmethyl)pyrrolidin-3-amine as selective noradrenaline reuptake inhibitors: Reducing P-gp mediated efflux by modulation of H-bond acceptor capacity.	Pfizer
18595716	142	Identification of a butyrophenone analog as a potential atypical antipsychotic agent: 4-[4-(4-chlorophenyl)-1,4-diazepan-1-yl]-1-(4-fluorophenyl)butan-1-one.	Florida A&M University
18571404	132	Designing rapid onset selective serotonin re-uptake inhibitors. 2: structure-activity relationships of substituted (aryl)benzylamines.	Pfizer
18557608	108	Structure-activity relationships of the cycloalkanol ethylamine scaffold: discovery of selective norepinephrine reuptake inhibitors.	Wyeth Research
18487050	36	Carbon-11 labeled indolylpropylamine analog as a new potential PET agent for imaging of the serotonin transporter.	Hadassah Hebrew University Hospital
18461921	65	Trifluoromethoxyl substituted phenylethylene diamines as high affinity sigma receptor ligands with potent anti-cocaine actions.	University Of Maryland
17698848	4	Ibogaine, a noncompetitive inhibitor of serotonin transport, acts by stabilizing the cytoplasm-facing state of the transporter.	Yale University
18085744	12	Synthesis and in vivo evaluation of halogenated N,N-dimethyl-2-(2'-amino-4'-hydroxymethylphenylthio)benzylamine derivatives as PET serotonin transporter ligands.	Emory University
18052090	39	2-(2'-((dimethylamino)methyl)-4'-(fluoroalkoxy)-phenylthio)benzenamine derivatives as serotonin transporter imaging agents.	University Of Pennsylvania
17900912	15	1-Aminocyclopentane-1,2,4-tricarboxylic acids screening on glutamatergic and serotonergic systems.	Università
17869101	60	High dopamine transporter selectivity can be displayed by remarkably simple non-nitrogen containing inhibitors.	University Of Aarhus
17766114	2	Synthesis and characterization of a pegylated derivative of 3-(1,2,3,6-tetrahydro-pyridin-4yl)-1H-indole (IDT199): a high affinity SERT ligand for conjugation to quantum dots.	Vanderbilt University
17765543	56	Dual serotonin transporter inhibitor/histamine H3 antagonists: development of rigidified H3 pharmacophores.	Johnson & Johnson Pharmaceutical Research And Development
17761416	53	The discovery of 6-amino nicotinamides as potent and selective histone deacetylase inhibitors.	Merck Research Laboratories
17705359	3	Synthesis and in vivo evaluation of fluorine-18 and iodine-123 labeled 2beta-carbo(2-fluoroethoxy)-3beta-(4'-((Z)-2-iodoethenyl)phenyl)nortropane as a candidate serotonin transporter imaging agent.	Emory University
17690258	2	LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake.	New York University School Of Medicine
17616397	107	Benzylamine histamine H(3) antagonists and serotonin reuptake inhibitors.	Johnson & Johnson Pharmaceutical Research & Development
17583504	51	Pyrrolidino-tetrahydroisoquinolines bearing pendant heterocycles as potent dual H3 antagonist and serotonin transporter inhibitors.	Johnson & Johnson Pharmaceutical Research & Development
17571866	49	Synthesis and simple 18F-labeling of 3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethynyl)benzonitrile as a high affinity radioligand for imaging monkey brain metabotropic glutamate subtype-5 receptors with positron emission tomography.	National Institute Of Mental Health
17446069	15	Synthesis and biological evaluation of 2beta,3alpha-(substituted phenyl)nortropanes as potential norepinephrine transporter imaging agents.	Emory University
17434731	51	Naphthyl piperazines with dual activity as 5-HT1D antagonists and 5-HT reuptake inhibitors.	Eli Lilly
17418570	141	CC chemokine receptor-3 (CCR3) antagonists: improving the selectivity of DPC168 by reducing central ring lipophilicity.	Bristol-Myers Squibb Pharmaceutical Research Institute
17412583	81	Synthesis and biological evaluation of diamine-based histamine H3 antagonists with serotonin reuptake inhibitor activity.	Johnson & Johnson Pharmaceutical Research & Development
17391962	27	Conformationally restricted homotryptamines 3. Indole tetrahydropyridines and cyclohexenylamines as selective serotonin reuptake inhibitors.	Bristol-Myers Squibb Pharmaceutical Research Institute
17307358	81	Novel naphthyridines are histamine H3 antagonists and serotonin reuptake transporter inhibitors.	Johnson & Johnson Pharmaceutical Research & Development
17267217	76	N-Benzyl-N-(tetrahydro-2H-pyran-4-yl)pyrrolidin-3-amines as selective dual serotonin/noradrenaline reuptake inhibitors.	Pfizer
17154506	6	Synthesis, radiosynthesis, and biological evaluation of carbon-11 labeled 2beta-carbomethoxy-3beta-(3'-((Z)-2-haloethenyl)phenyl)nortropanes: candidate radioligands for in vivo imaging of the serotonin transporter with positron emission tomography.	Emory University
17127059	96	Novel tetrahydroisoquinolines are histamine H3 antagonists and serotonin reuptake inhibitors.	Johnson & Johnson Pharmaceutical Research And Development
17107798	90	Dual serotonin transporter/histamine H3 ligands: Optimization of the H3 pharmacophore.	Johnson & Johnson Pharmaceutical Research And Development
16931001	93	2,4-Disubstituted piperidines as selective CC chemokine receptor 3 (CCR3) antagonists: synthesis and selectivity.	Bristol-Myers Squibb Pharmaceutical Research Institute
16784855	22	Synthesis and monoamine transporter affinity of front bridged tricyclic 3beta-(4'-halo or 4'-methyl)phenyltropanes bearing methylene or carbomethoxymethylene on the bridge to the 2beta-position.	Emory University
16722655	28	Discovery of a novel, orally active, small molecule gonadotropin-releasing hormone (GnRH) receptor antagonist.	Pfizer
16722631	87	An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.	Predix Pharmaceuticals
16513343	3	(R)-sila-venlafaxine: a selective noradrenaline reuptake inhibitor for the treatment of emesis.	Paradigm Therapeutics
16509591	75	Design and synthesis of promiscuous high-affinity monoamine transporter ligands: unraveling transporter selectivity.	Niddk
16497500	128	N-Alkyl-N-arylmethylpiperidin-4-amines: novel dual inhibitors of serotonin and norepinephrine reuptake.	Eli Lilly
16458504	37	Synthesis, in vitro and in vivo evaluation of [O-methyl-11C] 2-{4-[4-(3-methoxyphenyl)piperazin-1-yl]-butyl}-4-methyl-2H-[1,2,4]-triazine-3,5-dione: a novel agonist 5-HT1A receptor PET ligand.	Columbia University College Of Physicians And Surgeons
16451060	3	Evaluation of carbon-11-labeled 2beta-carbomethoxy-3beta-[4'-((Z)-2-iodoethenyl)phenyl]nortropane as a potential radioligand for imaging the serotonin transporter by PET.	Emory University
16392816	113	1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity.	Alcon Research
16392798	46	Synthesis and in vivo validation of [O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)piperazin- 1-yl]butyl}-4-methyl-2H-[1,2,4]triazine-3,5-dione: a novel 5-HT1A receptor agonist positron emission tomography ligand.	Columbia University College Of Physicians And Surgeons
16361098	70	Synthesis and biological evaluation of novel hexahydro-pyrido[3',2':4,5]pyrrolo[1,2-a]pyrazines as potent and selective 5-HT(2C) receptor agonists.	F. Hoffmann-La Roche
16337793	39	Synthesis and in vitro evaluation of novel derivatives of diphenylsulfide as serotonin transporter ligands.	University Of Tours
16314097	113	Designing rapid onset selective serotonin re-uptake inhibitors. Part 1: Structure-activity relationships of substituted (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydro-1-naphthaleneamine.	Pfizer
16302792	19	Rhodamine-labeled 2beta-carbomethoxy-3beta-(3,4-dichlorophenyl)tropane analogues as high-affinity fluorescent probes for the dopamine transporter.	National Institute On Drug Abuse-Intramural Research Program
16298130	32	Advances toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 5.	Eli Lilly
16202585	30	Synthesis and monoamine transporter affinity of 3-aryl substituted trop-2-enes.	University Of Illinois At Chicago
16183285	4	Inhibitors of the serotonin transporter protein (SERT): the design and synthesis of biotinylated derivatives of 3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indoles. High-affinity serotonergic ligands for conjugation with quantum dots.	Vanderbilt University
16137883	84	1-Aryl-3,4-dihydro-1H-quinolin-2-one derivatives, novel and selective norepinephrine reuptake inhibitors.	Eli Lilly
15974579	36	Synthesis, in vitro characterization, and radiolabeling of N,N-dimethyl-2-(2'-amino-4'-substituted-phenylthio)benzylamines: potential candidates as selective serotonin transporter radioligands.	Emory University
15801845	45	Fluorinated diaryl sulfides as serotonin transporter ligands: synthesis, structure-activity relationship study, and in vivo evaluation of fluorine-18-labeled compounds as PET imaging agents.	Columbia University College Of Physicians And Surgeons
15771448	187	Discovery of a new series of centrally active tricyclic isoxazoles combining serotonin (5-HT) reuptake inhibition with alpha2-adrenoceptor blocking activity.	Janssen-Cilag
15456270	24	2-(2-(dimethylaminomethyl)phenoxy)-5-iodophenylamine: an improved serotonin transporter imaging agent.	University Of Pennsylvania
15357973	24	Ligand conformation has a definitive effect on 5-HT1A and serotonin reuptake affinity.	Bristol-Myers Squibb Pharmaceutical Research Institute
15239661	120	Studies toward the discovery of the next generation of antidepressants. 3. Dual 5-HT1A and serotonin transporter affinity within a class of N-aryloxyethylindolylalkylamines.	Wyeth Research
15177457	39	Synthesis and biological activity of some known and putative duloxetine metabolites.	Eli Lilly
15125959	72	Synthesis of 3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazoles, displaying combined 5-HT uptake inhibiting and alpha2-adrenoceptor antagonistic activities. Part 2: Further exploration on the cinnamyl moiety.	Janssen-Cilag
15109671	29	Advances toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 4.	Eli Lilly
15081025	23	Structural determinants for high 5-HT(2A) receptor affinity of spiro[9,10-dihydroanthracene]-9,3(')-pyrrolidine (SpAMDA).	Virginia Commonwealth University
15080991	38	Synthesis and monoamine transporter affinity of 3'-analogs of 2-beta-carbomethoxy-3-beta-(4'-iodophenyl)tropane (beta-CIT).	Yale School Of Medicine
14971892	32	Synthesis, radiosynthesis, and biological evaluation of carbon-11 and iodine-123 labeled 2beta-carbomethoxy-3beta-[4'-((Z)-2-haloethenyl)phenyl]tropanes: candidate radioligands for in vivo imaging of the serotonin transporter.	Emory University
14698193	43	Modulation of selective serotonin reuptake inhibitor and 5-HT1A antagonist activity in 8-aza-bicyclo[3.2.1]octane derivatives of 2,3-dihydro-1,4-benzodioxane.	Wyeth Research
14643350	38	Duloxetine (Cymbalta), a dual inhibitor of serotonin and norepinephrine reuptake.	Eli Lilly
14643338	124	Binding of beta-carbolines at 5-HT(2) serotonin receptors.	Virginia Commonwealth University
12951108	63	Bicyclo[2.2.1]heptanes as novel triple re-uptake inhibitors for the treatment of depression.	Eli Lilly
12877586	40	A second-generation 99m technetium single photon emission computed tomography agent that provides in vivo images of the dopamine transporter in primate brain.	Organix
12620070	24	Synthesis and characterization of iodine-123 labeled 2beta-carbomethoxy-3beta-(4'-((Z)-2-iodoethenyl)phenyl)nortropane. A ligand for in vivo imaging of serotonin transporters by single-photon-emission tomography.	Emory University
12372513	102	Indoline and piperazine containing derivatives as a novel class of mixed D(2)/D(4) receptor antagonists. Part 2: asymmetric synthesis and biological evaluation.	Neurogen
12361398	19	New PET imaging agent for the serotonin transporter: [(18)F]ACF (2-[(2-amino-4-chloro-5-fluorophenyl)thio]-N,N-dimethyl-benzenmethanamine).	University Of Pennsylvania
12213078	31	Piperidine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909): high affinity ligands for the dopamine transporter.	Niddk
12213054	38	Benzo- and cyclohexanomazindol analogues as potential inhibitors of the cocaine binding site at the dopamine transporter.	Drew University
11814784	53	Studies toward the discovery of the next generation of antidepressants. Part 2: incorporating a 5-HT(1A) antagonist component into a class of serotonin reuptake inhibitors.	Wyeth-Ayerst Research Laboratories
10956218	12	Novel radiotracers for imaging the serotonin transporter by positron emission tomography: synthesis, radiosynthesis, and in vitro and ex vivo evaluation of (11)C-labeled 2-(phenylthio)araalkylamines.	Centre For Addiction And Mental Health
10715164	57	2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors.	Virginia Commonwealth University
10691690	6	Synthesis, biodistribution, and primate imaging of fluorine-18 labeled 2beta-carbo-1'-fluoro-2-propoxy-3beta-(4-chlorophenyl)tr opanes. Ligands for the imaging of dopamine transporters by positron emission tomography.	Emory University
10669578	44	New selective and potent 5-HT(1B/1D) antagonists: chemistry and pharmacological evaluation of N-piperazinylphenyl biphenylcarboxamides and biphenylsulfonamides.	University Of Groningen
10576690	13	Synthesis and biological evaluation of two novel DAT-binding technetium complexes containing a piperidine based analogue of cocaine.	Georgetown University Medical Center
9986702	11	A new single-photon emission computed tomography imaging agent for serotonin transporters: [123I]IDAM, 5-iodo-2-((2-((dimethylamino)methyl)phenyl)thio)benzyl alcohol.	University Of Pennsylvania
9871666	4	Design and synthesis of a biotinylated dopamine transporter ligand for the purification and labeling of dopaminergic neurons.	Novartis Pharma
9703474	21	Tolerance in the replacement of the benzhydrylic O atom in 4-[2-(diphenylmethoxy)ethyl]-1-benzylpiperidine derivatives by an N atom: development of new-generation potent and selective N-analogue molecules for the dopamine transporter.	Organix
9191960	21	A technetium-99m SPECT imaging agent which targets the dopamine transporter in primate brain.	Organix
8515428	2	Enantioselectivity of cocaine recognition sites: binding of (1S)- and (1R)-2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane (beta-CIT) to monoamine transporters.	Northeastern University
22803662	7	Synthesis, antielastase, antioxidant and radical scavenging activities of 4-(aza substituted) methylene substituted dihydroxy coumarines.	Giresun University
26864917	3	Discovery of Novel Allosteric Eg5 Inhibitors Through Structure-Based Virtual Screening.	Southern Research Institute
26943478	16	Synthesis and anti-acetylcholinesterase activity of scopoletin derivatives.	Chulabhorn Research Institute
26214585	23	Virtual Screening for UDP-Galactopyranose Mutase Ligands Identifies a New Class of Antimycobacterial Agents.	University Of Wisconsin-Madison
9349523	22	Cloning and expression of a human serotonin 5-HT4 receptor cDNA.	Janssen Research Foundation
2530094	94	The dopamine inhibitor GBR 12909: selectivity and molecular mechanism of action.	Novo Industri
16807364	18	Inhibition of the enzymatic activity of heme oxygenases by azole-based antifungal drugs.	Queen'S University
19326941	104	Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6.	Washington University
18221310	180	Rhodanine derivatives as selective protease inhibitors against bacterial toxins.	Burnham Institute For Medical Research
16731764	10	CRA-024781: a novel synthetic inhibitor of histone deacetylase enzymes with antitumor activity in vitro and in vivo.	Celera Genomics
18434145	56	Discovery of a novel and potent series of thieno[3,2-b]pyridine-based inhibitors of c-Met and VEGFR2 tyrosine kinases.	Methylgene
15771455	110	Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating hydrazino moieties.	Universita Degli Studi Di Firenze