282 articles for thisTarget

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The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
28657744	167	Discovery of N-Substituted (2-Phenylcyclopropyl)methylamines as Functionally Selective Serotonin 2C Receptor Agonists for Potential Use as Antipsychotic Medications.	University of Illinois At Chicago
28635286	207	Utilization of an Active Site Mutant Receptor for the Identification of Potent and Selective Atypical 5-HT	Bristol-Myers Squibb
27997171	48	Pyrimidine-Based Inhibitors of Dynamin I GTPase Activity: Competitive Inhibition at the Pleckstrin Homology Domain.	The University of Newcastle
12392747	36	SB-656104-A: a novel 5-HT(7) receptor antagonist with improved in vivo properties.	Glaxosmithkline
11992776	70	Bicyclic piperazinylbenzenesulphonamides are potent and selective 5-HT6 receptor antagonists.	Glaxosmithkline
11266169	27	Design and synthesis of novel 2,3-dihydro-1H-isoindoles with high affinity and selectivity for the dopamine D3 receptor.	Smithkline Beecham Pharmaceuticals
11597412	116	Novel (4-piperazin-1-ylquinolin-6-yl) arylsulfonamides with high affinity and selectivity for the 5-HT(6) receptor.	Glaxosmithkline
11459658	18	1,3-Biarylureas as selective non-peptide antagonists of the orexin-1 receptor.	Glaxosmithkline
10969987	63	1-[2-[(Heteroarylmethoxy)aryl]carbamoyl]indolines are selective and orally active 5-HT2C receptor inverse agonists.	Smithkline Beecham Pharmaceuticals
10969986	123	1-[2-[(Heteroaryloxy)heteroaryl]carbamoyl]indolines: novel and selective 5-HT2C receptor inverse agonists with potential as antidepressant/anxiolytic agents.	Smithkline Beecham Pharmaceuticals
27876250	60	Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH	Jagiellonian University Medical College
27908761	55	Discovery of dual positive allosteric modulators (PAMs) of the metabotropic glutamate 2 receptor and CysLT1 antagonists for treating migraine headache.	Eli Lilly
27864071	116	Tetrahydroquinoline-based tricyclic amines as potent and selective agonists of the 5-HT	Arena Pharmaceuticals
27839919	192	Decahydrobenzoquinolin-5-one sigma receptor ligands: Divergent development of both sigma 1 and sigma 2 receptor selective examples.	University of Kansas
27933810	166	Structure-Based Scaffold Repurposing for G Protein-Coupled Receptors: Transformation of Adenosine Derivatives into 5HT	National Institute of Diabetes and Digestive and Kidney Diseases
27717652	275	Synthesis and evaluation of the structural elements in alkylated tetrahydroisoquinolines for binding to CNS receptors.	Florida A&M University
27490827	24	Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy.	Pfizer
27364609	230	Development of CNS multi-receptor ligands: Modification of known D2 pharmacophores.	Florida A&M University
27312422	219	Design and synthesis of dual 5-HT1A and 5-HT7 receptor ligands.	Florida A&M University
27261181	45	New halogenated tris-(phenylalkyl)amines as h5-HT2B receptor ligands.	City University of New York
26988801	55	Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.	Jagiellonian University Medical College
26704965	229	Further Advances in Optimizing (2-Phenylcyclopropyl)methylamines as Novel Serotonin 2C Agonists: Effects on Hyperlocomotion, Prepulse Inhibition, and Cognition Models.	University of Illinois At Chicago
26700945	68	Structure-Based Discovery of Novel and Selective 5-Hydroxytryptamine 2B Receptor Antagonists for the Treatment of Irritable Bowel Syndrome.	National Institute of Biological Sciences, Beijing
26852005	82	Novel N-acyl-carbazole derivatives as 5-HT7R antagonists.	Yonsei University
26810316	29	Discovery of 5-aryl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-ones as positive allosteric modulators of metabotropic glutamate subtype-2 (mGlu2) receptors with efficacy in a preclinical model of psychosis.	Merck Research Laboratories
26739781	237	Receptor binding profiles and quantitative structure-affinity relationships of some 5-substituted-N,N-diallyltryptamines.	The Alexander Shulgin Research Institute
26475518	19	Synthesis and evaluation of aporphine analogs containing C1 allyl isosteres at the h5-HT(2A) receptor.	City University of New York
26421921	43	Design, Synthesis, and Pharmacological Evaluation of 5,6-Disubstituted Pyridin-2(1H)-one Derivatives as Phosphodiesterase 10A (PDE10A) Antagonists.	Glenmark Research Centre
26099069	15	Therapeutic Potential of 5-HT6 Receptor Agonists.	Universit£
26191370	34	Rigidified A3 Adenosine Receptor Agonists: 1-Deazaadenine Modification Maintains High in Vivo Efficacy.	National Institute of Diabetes and Digestive and Kidney Diseases
26227772	22	C4 phenyl aporphines with selective h5-HT(2B) receptor affinity.	City University of New York
26270954	7	Synthesis and Characterization of 5-Hydroxy-2-(2-phenylethyl)chromone (5-HPEC) and Its Analogues as Non-nitrogenous 5-HT2B Ligands.	Virginia Commonwealth University
25695425	62	Semisynthetic Studies on and Biological Evaluation of N-Methyllaurotetanine Analogues as Ligands for 5-HT Receptors.	City University of New York
25815155	21	Design, Synthesis, and Evaluation of Tetrasubstituted Pyridines as Potent 5-HT2C Receptor Agonists.	University of Cambridge
25633969	96	Optimization of 2-phenylcyclopropylmethylamines as selective serotonin 2C receptor agonists and their evaluation as potential antipsychotic agents.	University of Illinois At Chicago
25422861	78	In vivo phenotypic screening for treating chronic neuropathic pain: modification of C2-arylethynyl group of conformationally constrained A3 adenosine receptor agonists.	National Institute of Diabetes and Digestive and Kidney Diseases
25703249	132	Novel 4-substituted-N,N-dimethyltetrahydronaphthalen-2-amines: synthesis, affinity, and in silico docking studies at serotonin 5-HT2-type and histamine H1 G protein-coupled receptors.	University of Florida
25699143	26	Evaluation and synthesis of polar aryl- and heteroaryl spiroazetidine-piperidine acetamides as ghrelin inverse agonists.	Pfizer
25070422	126	Further evaluation of the tropane analogs of haloperidol.	Florida A&M University
24916029	42	Synthesis and structure-activity relationships of new carbonyl guanidine derivatives as novel dual 5-HT2B and 5-HT7 receptor antagonists. Part 2.	Astellas Pharma
24863744	15	DDD-028: a potent potential non-opioid, non-cannabinoid analgesic for neuropathic and inflammatory pain.	University of Missouri
25241924	47	The design and implementation of a generic lipopeptide scanning platform to enable the identification of 'locally acting' agonists for the apelin receptor.	Novartis Institutes For Biomedical Research
24900864	21	Discovery of PF-5190457, a Potent, Selective, and Orally Bioavailable Ghrelin Receptor Inverse Agonist Clinical Candidate.	Pfizer
24878222	50	Multiparameter optimization in CNS drug discovery: design of pyrimido[4,5-d]azepines as potent 5-hydroxytryptamine 2C (5-HT2C) receptor agonists with exquisite functional selectivity over 5-HT2A and 5-HT2B receptors.	Pfizer
24800940	146	Identification of a new selective dopamine D4 receptor ligand.	Florida A&M University
24279689	56	Prostanoid receptor EP2 as a therapeutic target.	Emory University
24704027	31	Lactam and oxazolidinone derived potent 5-hydroxytryptamine 6 receptor antagonists.	Cephalon
24690494	92	Antagonists of the kappa opioid receptor.	The Scripps Research Institute
24900826	22	Selective 5-HT Receptor Modulators May Deliver Focused Targeting with Fewer Adverse Effects.	Therachem Research Medilab (India)
24900821	5	Quinoline Derivatives as 5-HT6 Receptor PET Ligands.	Dart Neuroscience
16730983	165	Diaryl substituted pyrrolidinones and pyrrolones as 5-HT2C inhibitors: synthesis and biological evaluation.	Glaxosmithkline
23477943	51	Discovery of disubstituted piperidines and homopiperidines as potent dual NK1 receptor antagonists-serotonin reuptake transporter inhibitors for the treatment of depression.	Bristol-Myers Squibb
23560650	46	Synthesis and biological evaluation of a new series of hexahydro-2H-pyrano[3,2-c]quinolines as novel selectives1 receptor ligands.	Esteve
23374867	40	Discovery of (1R,2R)-N-(4-(6-isopropylpyridin-2-yl)-3-(2-methyl-2H-indazol-5-yl)isothiazol-5-yl)-2-methylcyclopropanecarboxamide, a potent and orally efficacious mGlu5 receptor negative allosteric modulator.	Eli Lilly
23177783	130	Synthesis and SAR of 2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-ones as 5-HT2C receptor agonists.	Bristol-Myers Squibb Research and Development
23425156	24	The discovery of novel potent trans-3,4-disubstituted pyrrolidine inhibitors of the human aspartic protease renin from in silico three-dimensional (3D) pharmacophore searches.	Novartis Pharma
23606928	14	Synthesis of novel analogs of cabergoline: improving cardiovascular safety by removing 5-HT2B receptor agonism.	University of Minnesota
20674357	66	Novel imidazobenzazepine derivatives as dual H1/5-HT2A antagonists for the treatment of sleep disorders.	Glaxosmithkline
19146417	70	The discovery of a selective, small molecule agonist for the MAS-related gene X1 receptor.	Glaxosmithkline
18829312	64	Novel 5-HT(1A/1B/1D) receptors antagonists with potent 5-HT reuptake inhibitory activity.	Glaxosmithkline
18433113	124	Discovery of potent, orally bioavailable, selective 5-HT1A/B/D receptor antagonists.	Glaxosmithkline
16168649	65	A series of bisaryl imidazolidin-2-ones has shown to be selective and orally active 5-HT2C receptor antagonists.	Glaxosmithkline
11140733	92	Phenyl benzenesulfonamides are novel and selective 5-HT6 antagonists: identification of N-(2,5-dibromo-3-fluorophenyl)-4-methoxy-3-piperazin-1-ylbenzenesulfonamide (SB-357134).	Smithkline Beecham Pharmaceuticals
23084435	17	Synthesis of N-phenyl-N-(3-(piperidin-1-yl)propyl)benzofuran-2-carboxamides as new selective ligands for sigma receptors.	Savannah State University
22959245	175	As(1) receptor pharmacophore derived from a series of N-substituted 4-azahexacyclo[5.4.1.0(2,6).0(3,10).0(5,9).0(8,11)]dodecan-3-ols (AHDs).	The University of Sydney
23641311	38	From a4ß2 Nicotinic Ligands to the Discovery of s1 Receptor Ligands: Pharmacophore Analysis and Rational Design.	TBA
23102207	122	Synthesis and structure-affinity relationships of selective high-affinity 5-HT(4) receptor antagonists: application to the design of new potential single photon emission computed tomography tracers.	Universit£
22784008	100	Synthesis and biological evaluation of the 1-arylpyrazole class ofs(1) receptor antagonists: identification of 4-{2-[5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine (S1RA, E-52862).	Esteve
22664127	19	Antagonists of 5-HT6 receptors. Substituted 3-(phenylsulfonyl)pyrazolo[1,5-a]pyrido[3,4-e]pyrimidines and 3-(phenylsulfonyl)pyrazolo[1,5-a]pyrido[4,3-d]pyrimidines-Synthesis and 'structure-activity' relationship.	Chemical Diversity Research Institute
22845053	100	Structure-functional selectivity relationship studies ofß-arrestin-biased dopamine D2 receptor agonists.	University of North Carolina At Chapel Hill
22738628	38	Moderate chemical modifications of WAY-100635 improve the selectivity for 5-HT1A versus D4 receptors.	University of Li£Ge
22694093	16	Life beyond kinases: structure-based discovery of sorafenib as nanomolar antagonist of 5-HT receptors.	National Institute of Biological Sciences
22386241	46	Synthesis and pharmacological evaluation of carbamic acid 1-phenyl-3-(4-phenyl-piperazine-1-yl)-propyl ester derivatives as new analgesic agents.	Sk Biopharmaceuticals
22313242	146	2-(Pyrrolidin-1-yl)ethyl-3,4-dihydroisoquinolin-1(2H)-one derivatives as potent and selective histamine-3 receptor antagonists.	Pfizer
22313227	78	Radiosynthesis and evaluation of an (18)F-labeled positron emission tomography (PET) radioligand for brain histamine subtype-3 receptors based on a nonimidazole 2-aminoethylbenzofuran chemotype.	National Institute of Mental Health
22778800	24	Rational Drug Design Leading to the Identification of a Potent 5-HT(2C) Agonist Lacking 5-HT(2B) Activity.	TBA
22465637	48	4-(1-Phenyl-1H-pyrazol-4-yl)quinolines as novel, selective and brain penetrant metabotropic glutamate receptor 4 positive allosteric modulators.	Lundbeck Research Usa
21726069	98	Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators.	University of Namur
21207959	69	Syntheses of 2-amino and 2-halothiazole derivatives as high-affinity metabotropic glutamate receptor subtype 5 ligands and potential radioligands for in vivo imaging.	National Institute of Mental Health
20727749	17	Pyrazolo[1,5-a]pyrimidine acetamides: 4-Phenyl alkyl ether derivatives as potent ligands for the 18 kDa translocator protein (TSPO).	University of Sydney
20684563	176	Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 receptor agonist with unprecedented selectivity and procognitive potential.	H. Lundbeck
20560595	21	(3-Phenylsulfonylcycloalkano[e and d]pyrazolo[1,5-a]pyrimidin-2-yl)amines: potent and selective antagonists of the serotonin 5-HT6 receptor.	Chemical Diversity Research Institute
19963380	38	Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine.	Hunter College and The Graduate Center of The City University of New York
19720528	54	Tetrahydrocarbazole-based serotonin reuptake inhibitor/dopamine D2 partial agonists for the potential treatment of schizophrenia.	Wyeth Research
18468904	48	High specific activity tritium-labeled N-(2-methoxybenzyl)-2,5-dimethoxy-4-iodophenethylamine (INBMeO): a high-affinity 5-HT2A receptor-selective agonist radioligand.	Purdue University
18083579	33	Synthesis and structure-activity relationships of a series of benzazepine derivatives as 5-HT2C receptor agonists.	Astellas Pharma
18035544	52	Synthesis and structure-activity relationships of a series of substituted 2-(1H-furo[2,3-g]indazol-1-yl)ethylamine derivatives as 5-HT2C receptor agonists.	Astellas Pharma
18282705	69	2-Alkyl-4-aryl-pyrimidine fused heterocycles as selective 5-HT2A antagonists.	Johnson & Johnson Pharmaceutical Research and Development
17998160	101	Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation.	F. Hoffmann-La Roche
16198561	99	Novel CCR1 antagonists with oral activity in the mouse collagen induced arthritis.	Novartis Institutes For Biomedical Research
12954071	109	A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole.	Alcon Research
12213075	70	Lysergamides of isomeric 2,4-dimethylazetidines map the binding orientation of the diethylamide moiety in the potent hallucinogenic agent N,N-diethyllysergamide (LSD).	Purdue University
11708905	20	N-[3-(2-Dimethylaminoethyl)-2-methyl-1H- indol-5-yl]-4-fluorobenzamide: a potent, selective, and orally active 5-HT(1F) receptor agonist potentially useful for migraine therapy.	Eli Lilly
15203136	39	(+/-)8-Amino-5,6,7,8-tetrahydroisoquinolines as novel antinociceptive agents.	Virginia Commonwealth University
22226656	75	Discovery of 7-arylsulfonyl-1,2,3,4, 4a,9a-hexahydro-benzo[4,5]furo[2,3-c]pyridines: identification of a potent and selective 5-HT6 receptor antagonist showing activity in rat social recognition test.	Cephalon
22153937	52	Novel brain penetrant benzofuropiperidine 5-HT6 receptor antagonists.	Cephalon
22001031	6	Usabamycins A-C: new anthramycin-type analogues from a marine-derived actinomycete.	Nippon Suisan Kaisha
22000209	54	Design, synthesis and in vitro evaluation of bridgehead fluoromethyl analogs of N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexanecarboxamide (WAY-100635) for the 5-HT(1A) receptor.	Vu University Medical Center
21871797	33	Effects of linker elongation in a series of N-(2-benzofuranylmethyl)-N'-(methoxyphenylalkyl)piperazines¿? receptor ligands.	The University of Sydney
21782428	61	Discovery of Lu AA33810: a highly selective and potent NPY5 antagonist with in vivo efficacy in a model of mood disorder.	Lundbeck Research Usa
21907583	48	CNS and antimalarial activity of synthetic meridianin and psammopemmin analogs.	University of South Florida
21195614	56	Pyrimido[4,5-d]azepines as potent and selective 5-HT2C receptor agonists: design, synthesis, and evaluation of PF-3246799 as a treatment for urinary incontinence.	Pfizer
21333408	21	2-Substituted 5,6-dimethyl-3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidines: new series of highly potent and specific serotonin 5-HT6 receptor antagonists.	Chemical Diversity Research Institute
21028889	7	Pulicatins A-E, neuroactive thiazoline metabolites from cone snail-associated bacteria.	University of Utah
21093272	126	Identification of 3-sulfonylindazole derivatives as potent and selective 5-HT(6) antagonists.	Wyeth Research
21146989	46	Trishomocubane as a scaffold for the development of selective dopamine transporter (DAT) ligands.	The University of Sydney
21146986	50	Novel 6,7,8,9-tetrahydro-5H-1,4,7,10a-tetraaza-cyclohepta[f]indene analogues as potent and selective 5-HT(2C) agonists for the treatment of metabolic disorders.	Evotec
20958049	12	Development, validation, and use of quantitative structure-activity relationship models of 5-hydroxytryptamine (2B) receptor ligands to identify novel receptor binders and putative valvulopathic compounds among common drugs.	University of North Carolina At Chapel Hill
20949929	63	Conformationally restricted homotryptamines. Part 7: 3-cis-(3-aminocyclopentyl)indoles as potent selective serotonin reuptake inhibitors.	Bristol-Myers Squibb
20932009	127	5-Piperazinyl-3-sulfonylindazoles as potent and selective 5-hydroxytryptamine-6 antagonists.	Wyeth Research
20812727	157	Synthesis, structure-affinity relationships, and radiolabeling of selective high-affinity 5-HT4 receptor ligands as prospective imaging probes for positron emission tomography.	National Institute of Mental Health
20813948	63	Spiroindolones, a potent compound class for the treatment of malaria.	Swiss Tropical and Public Health Institute
20692833	41	N-tetrahydrothiochromenoisoxazole-1-carboxamides as selective antagonists of cloned human 5-HT2B.	Csiro Molecular and Health Technologies
20662542	64	Design, synthesis, and structure-affinity relationships of regioisomeric N-benzyl alkyl ether piperazine derivatives as sigma-1 receptor ligands.	University of Sydney
20620058	41	Smoothened antagonists for hair inhibition.	Pfizer
20455563	49	Discovery and structure-activity relationship of 3-methoxy-N-(3-(1-methyl-1H-pyrazol-5-yl)-4-(2-morpholinoethoxy)phenyl)benzamide (APD791): a highly selective 5-hydroxytryptamine2A receptor inverse agonist for the treatment of arterial thrombosis.	Arena Pharmaceuticals
20207539	15	Synthesis of cycloalkane-annelated 3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidines and their evaluation as 5-HT6 receptor antagonists.	Chemical Diversity Research Institute
20202843	40	Orally active and brain permeable proline amides as highly selective 5HT2c agonists for the treatment of obesity.	Pfizer
19786348	261	Benzoxazole piperidines as selective and potent somatostatin receptor subtype 5 antagonists.	F. Hoffmann-La Roche
20022752	94	Tricyclic dihydroquinazolinones as novel 5-HT2C selective and orally efficacious anti-obesity agents.	Bristol-Myers Squibb
20170099	58	5-Cyclic amine-3-arylsulfonylindazoles as novel 5-HT6 receptor antagonists.	Wyeth Research
19914063	84	Design and synthesis of orally-active and selective azaindane 5HT2c agonist for the treatment of obesity.	Pfizer
19646882	72	Novel delta opioid receptor agonists exhibit differential stimulation of signaling pathways.	University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School and The Informatics Institute of Umdnj
19773162	72	Pyrimidine-based antagonists of h-MCH-R1 derived from ATC0175: in vitro profiling and in vivo evaluation.	Arena Pharmaceuticals
19716297	45	Design and synthesis of pyridazinone-based 5-HT(2C) agonists.	Pfizer
19692241	36	Design and synthesis of piperazinylpyrimidinones as novel selective 5-HT(2C) agonists.	Pfizer
19646865	45	Discovery of a novel azepine series of potent and selective 5-HT2C agonists as potential treatments for urinary incontinence.	Pfizer
19783143	65	Special ergolines are highly selective, potent antagonists of the chemokine receptor CXCR3: discovery, characterization and preliminary SAR of a promising lead.	Novartis Institutes For Biomedical Research
19329329	183	Synthesis and in vitro affinities of various MDL 100907 derivatives as potential 18F-radioligands for 5-HT2A receptor imaging with PET.	Institute of Nuclear Chemistry Johannes Gutenberg-University Mainz
19307114	73	A new class of 5-HT2B antagonists possesses favorable potency, selectivity, and rat pharmacokinetic properties.	Boehringer Ingelheim Pharmaceuticals
19284718	191	Selective 5-hydroxytryptamine 2C receptor agonists derived from the lead compound tranylcypromine: identification of drugs with antidepressant-like action.	University of Illinois At Chicago
19269173	81	7-Sulfonamido-3-benzazepines as potent and selective 5-HT2C receptor agonists: hit-to-lead optimization.	Pfizer
18701276	97	Highly functionalized 7-azaindoles as selective PPAR gamma modulators.	Merck Research Laboratories
18640038	74	Structural modifications of N-arylamide oxadiazoles: Identification of N-arylpiperidine oxadiazoles as potent and selective agonists of CB2.	Amgen
18621528	133	Derivatives of (3S)-N-(biphenyl-2-ylmethyl)pyrrolidin-3-amine as selective noradrenaline reuptake inhibitors: Reducing P-gp mediated efflux by modulation of H-bond acceptor capacity.	Pfizer
18595716	142	Identification of a butyrophenone analog as a potential atypical antipsychotic agent: 4-[4-(4-chlorophenyl)-1,4-diazepan-1-yl]-1-(4-fluorophenyl)butan-1-one.	Florida A&M University
18573659	47	Urotensin-II receptor antagonists: synthesis and SAR of N-cyclic azaalkyl benzamides.	Glaxosmithkline
18557608	108	Structure-activity relationships of the cycloalkanol ethylamine scaffold: discovery of selective norepinephrine reuptake inhibitors.	Wyeth Research
17571866	49	Synthesis and simple 18F-labeling of 3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethynyl)benzonitrile as a high affinity radioligand for imaging monkey brain metabotropic glutamate subtype-5 receptors with positron emission tomography.	National Institute of Mental Health
17315987	268	Discovery of (R)-9-ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol- 6(2H)-one, a selective, orally active agonist of the 5-HT(2C) receptor.	Pharmaceutical Research Institute
17178222	29	Quinazoline and benzimidazole MCH-1R antagonists.	Argenta Discovery
16844377	40	New spiro-piperidines as 5-HT2B receptor antagonists.	Hopital Saint-Louis
16722631	87	An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.	Predix Pharmaceuticals
16546379	30	The identification of pyrimidine-diazabicyclo[3.3.0]octane derivatives as 5-HT2C receptor agonists.	Athersys
16458504	37	Synthesis, in vitro and in vivo evaluation of [O-methyl-11C] 2-{4-[4-(3-methoxyphenyl)piperazin-1-yl]-butyl}-4-methyl-2H-[1,2,4]-triazine-3,5-dione: a novel agonist 5-HT1A receptor PET ligand.	Columbia University College of Physicians and Surgeons
16392816	113	1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity.	Alcon Research
16361098	70	Synthesis and biological evaluation of novel hexahydro-pyrido[3',2':4,5]pyrrolo[1,2-a]pyrazines as potent and selective 5-HT(2C) receptor agonists.	F. Hoffmann-La Roche
16257207	96	Pyrrolo(iso)quinoline derivatives as 5-HT(2C) receptor agonists.	Vernalis
16061378	87	SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist.	Organix
15975787	39	Identification of 4-methyl-1,2,3,4,10,10a-hexahydropyrazino[1,2-a]indoles as 5-HT2C receptor agonists.	Vernalis Research
15713408	96	Discovery and SAR of new benzazepines as potent and selective 5-HT(2C) receptor agonists for the treatment of obesity.	Arena Pharmaceuticals
15225734	10	Structure-activity relationships of a novel series of melanin-concentrating hormone (MCH) receptor antagonists.	Argenta Discovery
15109661	21	Cycloalkyl[b][1,4]benzodiazepinoindoles are agonists at the human 5-HT2C receptor.	Wyeth Research
15081042	84	Indoline derivatives as 5-HT(2C) receptor agonists.	Vernalis Research
12825944	184	Novel potent 5-HT(1F) receptor agonists: structure-activity studies of a series of substituted N-[3-(1-methyl-4-piperidinyl)-1H-pyrrolo[3,2-b]pyridin-5-yl]amides.	Eli Lilly
12643910	55	Identification of a novel series of selective 5-HT7 receptor antagonists.	Glaxosmithkline
12502367	17	New benzo[h][1,6]naphthyridine and azepino[3,2-c]quinoline derivatives as selective antagonists of 5-HT4 receptors: binding profile and pharmacological characterization.	Université
11514164	36	Conformationally restricted indolopiperidine derivatives as potent CCR2B receptor antagonists.	Glaxosmithkline
32527538	30	Azetidine-based selective glycine transporter-1 (GlyT1) inhibitors with memory enhancing properties.	Dart Neuroscience
32551645	51	2-Arylbenzo[	University of Oxford
31952960	234	Discovery of a lead series of potent benzodiazepine 5-HT	Arena Pharmaceuticals
32227883	40	Isolation and Synthesis of Veranamine, an Antidepressant Lead from the Marine Sponge	University of Mississippi
27410258	21	South (S)- and North (N)-Methanocarba-7-Deazaadenosine Analogues as Inhibitors of Human Adenosine Kinase.	National Institute of Diabetes and Digestive and Kidney Diseases
27381086	68	Selective 5-HT2C receptor agonists: Design and synthesis of pyridazine-fused azepines.	Pfizer
30622024	9	Identification of dual role of piperazine-linked phenyl cyclopropyl methanone as positive allosteric modulator of 5-HT	Csir-Central Drug Research Institute (Csir-Cdri)
30597325	17	Synthesis of spiro-2,6-dioxopiperazine and spiro-2,6-dioxopyrazine scaffolds using amino acids in a three-component reaction to generate potential Sigma-1 (?	Memorial Sloan Kettering Cancer Center
10737744	146	Biarylcarbamoylindolines are novel and selective 5-HT(2C) receptor inverse agonists: identification of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]- 5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic agent.	Smithkline Beecham Pharmaceuticals
31298539	18	Design, Synthesis, and Characterization of Ogerin-Based Positive Allosteric Modulators for G Protein-Coupled Receptor 68 (GPR68).	Icahn School of Medicine At Mount Sinai
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31586817	96	Synthesis and biological evaluation of new multi-target 3-(1H-indol-3-yl)pyrrolidine-2,5-dione derivatives with potential antidepressant effect.	Medical University of Warsaw
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