Found 677 hits with Last Name = 'gwaltney' and Initial = 'sl' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Tubulin beta-2B chain
(Bos taurus) | BDBM50005480
((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)Show InChI InChI=1S/C18H20O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11,19H,1-4H3/b6-5- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| PDB PubMed
| 180 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding constant at colchicine site of bovine brain tubulin |
Bioorg Med Chem Lett 12: 465-9 (2002)
BindingDB Entry DOI: 10.7270/Q2PC32W7 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Tubulin beta-2B chain
(Bos taurus) | BDBM50109343
(1-Methyl-5-[(S)-5-(3,4,5-trimethoxy-phenyl)-4,5-di...)Show SMILES COc1cc(cc(OC)c1OC)[C@H]1CN=C(O1)c1ccc2n(C)ccc2c1 |c:15| Show InChI InChI=1S/C21H22N2O4/c1-23-8-7-13-9-14(5-6-16(13)23)21-22-12-19(27-21)15-10-17(24-2)20(26-4)18(11-15)25-3/h5-11,19H,12H2,1-4H3/t19-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 630 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding constant at colchicine site of bovine brain tubulin |
Bioorg Med Chem Lett 12: 465-9 (2002)
BindingDB Entry DOI: 10.7270/Q2PC32W7 |
More data for this Ligand-Target Pair | |
Tubulin beta-2B chain
(Bos taurus) | BDBM50014846
((S)-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-...)Show SMILES COc1cc2CC[C@H](NC(C)=O)c3cc(=O)c(OC)ccc3-c2c(OC)c1OC |r| Show InChI InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB PubMed
| 780 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding constant at colchicine site of bovine brain tubulin |
Bioorg Med Chem Lett 12: 465-9 (2002)
BindingDB Entry DOI: 10.7270/Q2PC32W7 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Tubulin beta-2B chain
(Bos taurus) | BDBM50109342
(1-Methyl-5-[(R)-5-(3,4,5-trimethoxy-phenyl)-4,5-di...)Show SMILES COc1cc(cc(OC)c1OC)[C@@H]1CN=C(O1)c1ccc2n(C)ccc2c1 |c:15| Show InChI InChI=1S/C21H22N2O4/c1-23-8-7-13-9-14(5-6-16(13)23)21-22-12-19(27-21)15-10-17(24-2)20(26-4)18(11-15)25-3/h5-11,19H,12H2,1-4H3/t19-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 3.69E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding constant at colchicine site of bovine brain tubulin |
Bioorg Med Chem Lett 12: 465-9 (2002)
BindingDB Entry DOI: 10.7270/Q2PC32W7 |
More data for this Ligand-Target Pair | |
Tubulin beta-2B chain
(Bos taurus) | BDBM50012278
((2ALPHA,2''BETA,3BETA,4ALPHA,5BETA)-VINCALEUKOBLAS...)Show SMILES CC[C@]1(O)C[C@@H]2CN(C1)CCc1c([nH]c3ccccc13)[C@@](C2)(C(=O)OC)c1cc2c(cc1OC)N(C)[C@@H]1[C@]22CCN3CC=C[C@](CC)([C@@H]23)[C@@H](OC(C)=O)[C@]1(O)C(=O)OC |r,c:48| Show InChI InChI=1S/C46H58N4O9/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3/t28-,37-,38+,39+,42-,43+,44+,45-,46-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB PubMed
| >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding constant at colchicine site of bovine brain tubulin |
Bioorg Med Chem Lett 12: 465-9 (2002)
BindingDB Entry DOI: 10.7270/Q2PC32W7 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50135360
(5-(3-Chloro-phenyl)-6-[(4-cyano-phenyl)-(3-methyl-...)Show SMILES CCCn1c(COC(c2cncn2C)c2ccc(cc2)C#N)c(cc(C#N)c1=O)-c1cccc(Cl)c1 Show InChI InChI=1S/C28H24ClN5O2/c1-3-11-34-26(24(13-22(15-31)28(34)35)21-5-4-6-23(29)12-21)17-36-27(25-16-32-18-33(25)2)20-9-7-19(14-30)8-10-20/h4-10,12-13,16,18,27H,3,11,17H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.0360 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against farnesyltransferase (FT) |
Bioorg Med Chem Lett 13: 4001-5 (2003)
BindingDB Entry DOI: 10.7270/Q2H41QVX |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153786
(4-((5-((4-cyanophenoxy)methyl)-1H-imidazol-1-yl)me...)Show SMILES N#Cc1ccc(OCc2cncn2Cc2ccc(C#N)c(c2)-c2cccc3ccccc23)cc1 Show InChI InChI=1S/C29H20N4O/c30-15-21-9-12-26(13-10-21)34-19-25-17-32-20-33(25)18-22-8-11-24(16-31)29(14-22)28-7-3-5-23-4-1-2-6-27(23)28/h1-14,17,20H,18-19H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.320 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011 BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50135354
(6-[(3-Chloro-4-cyano-phenyl)-(3-methyl-3H-imidazol...)Show SMILES Cn1cncc1C(OCc1c(cc(C#N)c(=O)n1C)-c1ccc(OC(F)(F)F)cc1)c1ccc(C#N)c(Cl)c1 Show InChI InChI=1S/C27H19ClF3N5O3/c1-35-15-34-13-23(35)25(17-3-4-18(11-32)22(28)10-17)38-14-24-21(9-19(12-33)26(37)36(24)2)16-5-7-20(8-6-16)39-27(29,30)31/h3-10,13,15,25H,14H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.360 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against farnesyltransferase (FT) |
Bioorg Med Chem Lett 13: 4001-5 (2003)
BindingDB Entry DOI: 10.7270/Q2H41QVX |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153166
(3''-Chloro-6-[3-(4-cyano-benzyl)-3H-imidazol-4-ylm...)Show SMILES Clc1cccc(c1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N Show InChI InChI=1S/C26H19ClN4O/c27-24-3-1-2-22(11-24)26-10-21(13-29)8-9-23(26)16-32-17-25-14-30-18-31(25)15-20-6-4-19(12-28)5-7-20/h1-11,14,18H,15-17H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.370 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011 BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153802
(3'',4''-Dichloro-6-[3-(4-cyano-benzyl)-3H-imidazol...)Show SMILES Clc1ccc(cc1Cl)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N Show InChI InChI=1S/C26H18Cl2N4O/c27-25-8-7-21(10-26(25)28)24-9-20(12-30)5-6-22(24)15-33-16-23-13-31-17-32(23)14-19-3-1-18(11-29)2-4-19/h1-10,13,17H,14-16H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.370 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011 BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153785
(4-((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)-2-...)Show SMILES N#Cc1ccc(Cn2cncc2COc2ccc(C#N)c(c2)-c2cccc3ccccc23)cc1 Show InChI InChI=1S/C29H20N4O/c30-15-21-8-10-22(11-9-21)18-33-20-32-17-25(33)19-34-26-13-12-24(16-31)29(14-26)28-7-3-5-23-4-1-2-6-27(23)28/h1-14,17,20H,18-19H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.380 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011 BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50135391
(6-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)Show SMILES COc1cccc(c1)-c1cc(C#N)c(=O)n(C)c1COC(c1cncn1C)c1ccc(cc1)C#N Show InChI InChI=1S/C27H23N5O3/c1-31-17-30-15-24(31)26(19-9-7-18(13-28)8-10-19)35-16-25-23(12-21(14-29)27(33)32(25)2)20-5-4-6-22(11-20)34-3/h4-12,15,17,26H,16H2,1-3H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.410 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against farnesyltransferase (FT) |
Bioorg Med Chem Lett 13: 4001-5 (2003)
BindingDB Entry DOI: 10.7270/Q2H41QVX |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50135361
(6-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)Show SMILES Cn1cncc1C(OCc1c(cc(C#N)c(=O)n1C)-c1cccc(OC(F)(F)F)c1)c1ccc(cc1)C#N Show InChI InChI=1S/C27H20F3N5O3/c1-34-16-33-14-23(34)25(18-8-6-17(12-31)7-9-18)37-15-24-22(11-20(13-32)26(36)35(24)2)19-4-3-5-21(10-19)38-27(28,29)30/h3-11,14,16,25H,15H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.420 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against farnesyltransferase (FT) |
Bioorg Med Chem Lett 13: 4001-5 (2003)
BindingDB Entry DOI: 10.7270/Q2H41QVX |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50135367
(5-Benzo[1,3]dioxol-5-yl-6-[(4-cyano-phenyl)-(3-met...)Show SMILES Cn1cncc1C(OCc1c(cc(C#N)c(=O)n1C)-c1ccc2OCOc2c1)c1ccc(cc1)C#N Show InChI InChI=1S/C27H21N5O4/c1-31-15-30-13-22(31)26(18-5-3-17(11-28)4-6-18)34-14-23-21(9-20(12-29)27(33)32(23)2)19-7-8-24-25(10-19)36-16-35-24/h3-10,13,15,26H,14,16H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.420 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against farnesyltransferase (FT) |
Bioorg Med Chem Lett 13: 4001-5 (2003)
BindingDB Entry DOI: 10.7270/Q2H41QVX |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50135390
(6-[(3-Bromo-4-cyano-phenyl)-(3-methyl-3H-imidazol-...)Show SMILES Cn1cncc1C(OCc1c(cc(C#N)c(=O)n1C)-c1cc(Cl)cc(Cl)c1)c1ccc(C#N)c(Br)c1 Show InChI InChI=1S/C26H18BrCl2N5O2/c1-33-14-32-12-23(33)25(15-3-4-16(10-30)22(27)8-15)36-13-24-21(7-18(11-31)26(35)34(24)2)17-5-19(28)9-20(29)6-17/h3-9,12,14,25H,13H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.420 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against farnesyltransferase (FT) |
Bioorg Med Chem Lett 13: 4001-5 (2003)
BindingDB Entry DOI: 10.7270/Q2H41QVX |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153176
(4''-tert-Butyl-6-[3-(4-cyano-benzyl)-3H-imidazol-4...)Show SMILES CC(C)(C)c1ccc(cc1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N Show InChI InChI=1S/C30H28N4O/c1-30(2,3)27-12-10-25(11-13-27)29-14-24(16-32)8-9-26(29)19-35-20-28-17-33-21-34(28)18-23-6-4-22(15-31)5-7-23/h4-14,17,21H,18-20H2,1-3H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.440 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011 BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50135353
(5-(3-Chloro-phenyl)-6-[(4-cyano-phenyl)-(3-methyl-...)Show SMILES Cn1cncc1C(OCc1c(cc(C#N)c(=O)n1C)-c1cccc(Cl)c1)c1ccc(cc1)C#N Show InChI InChI=1S/C26H20ClN5O2/c1-31-16-30-14-23(31)25(18-8-6-17(12-28)7-9-18)34-15-24-22(19-4-3-5-21(27)10-19)11-20(13-29)26(33)32(24)2/h3-11,14,16,25H,15H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.440 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against farnesyltransferase (FT) |
Bioorg Med Chem Lett 13: 4001-5 (2003)
BindingDB Entry DOI: 10.7270/Q2H41QVX |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50135383
(6-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)Show SMILES Cn1cncc1C(OCc1c(cc(C#N)c(=O)n1C)-c1cc(Cl)cc(Cl)c1)c1ccc(cc1)C#N Show InChI InChI=1S/C26H19Cl2N5O2/c1-32-15-31-13-23(32)25(17-5-3-16(11-29)4-6-17)35-14-24-22(9-19(12-30)26(34)33(24)2)18-7-20(27)10-21(28)8-18/h3-10,13,15,25H,14H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.460 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against farnesyltransferase (FT) |
Bioorg Med Chem Lett 13: 4001-5 (2003)
BindingDB Entry DOI: 10.7270/Q2H41QVX |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM16181
(1-[2-(4-cyanophenyl)-2-hydroxy-2-(1-methyl-1H-imid...)Show SMILES Cn1cncc1C(O)(CN1CCC(C#N)=C(C1)c1cccc2ccccc12)c1ccc(cc1)C#N |c:15| Show InChI InChI=1S/C29H25N5O/c1-33-20-32-17-28(33)29(35,24-11-9-21(15-30)10-12-24)19-34-14-13-23(16-31)27(18-34)26-8-4-6-22-5-2-3-7-25(22)26/h2-12,17,20,35H,13-14,18-19H2,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| PubMed
| n/a | n/a | 0.480 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description In vitro inhibition of farnesyltransferase |
Bioorg Med Chem Lett 13: 1363-6 (2003)
BindingDB Entry DOI: 10.7270/Q24B30PD |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153172
(6-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)me...)Show SMILES FC(F)(F)Oc1cccc(c1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N Show InChI InChI=1S/C27H19F3N4O2/c28-27(29,30)36-25-3-1-2-22(11-25)26-10-21(13-32)8-9-23(26)16-35-17-24-14-33-18-34(24)15-20-6-4-19(12-31)5-7-20/h1-11,14,18H,15-17H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.490 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011 BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50135362
(6-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)Show SMILES Cn1cncc1C(OCc1c(cc(C#N)c(=O)n1C)-c1ccc(Cl)c(Cl)c1)c1ccc(cc1)C#N Show InChI InChI=1S/C26H19Cl2N5O2/c1-32-15-31-13-23(32)25(17-5-3-16(11-29)4-6-17)35-14-24-20(9-19(12-30)26(34)33(24)2)18-7-8-21(27)22(28)10-18/h3-10,13,15,25H,14H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.490 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against farnesyltransferase (FT) |
Bioorg Med Chem Lett 13: 4001-5 (2003)
BindingDB Entry DOI: 10.7270/Q2H41QVX |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50126326
(1-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)Show SMILES Cn1cncc1C(N1CCC(C#N)=C(C1)c1cccc2ccccc12)c1ccc(cc1)C#N |c:13| Show InChI InChI=1S/C28H23N5/c1-32-19-31-17-27(32)28(22-11-9-20(15-29)10-12-22)33-14-13-23(16-30)26(18-33)25-8-4-6-21-5-2-3-7-24(21)25/h2-12,17,19,28H,13-14,18H2,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description In vitro inhibition of farnesyltransferase |
Bioorg Med Chem Lett 13: 1363-6 (2003)
BindingDB Entry DOI: 10.7270/Q24B30PD |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50135389
(5-(3-Chloro-phenyl)-6-[(4-cyano-phenyl)-(3-methyl-...)Show SMILES Cn1cncc1C(OCc1c(cc(C#N)c(=O)n1CC1CC1)-c1cccc(Cl)c1)c1ccc(cc1)C#N Show InChI InChI=1S/C29H24ClN5O2/c1-34-18-33-15-26(34)28(21-9-7-19(13-31)8-10-21)37-17-27-25(22-3-2-4-24(30)11-22)12-23(14-32)29(36)35(27)16-20-5-6-20/h2-4,7-12,15,18,20,28H,5-6,16-17H2,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against farnesyltransferase (FT) |
Bioorg Med Chem Lett 13: 4001-5 (2003)
BindingDB Entry DOI: 10.7270/Q2H41QVX |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50126320
(1-{[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-m...)Show SMILES Cn1cncc1C(NN1CCC(C#N)=C(C1)c1cccc2ccccc12)c1ccc(cc1)C#N |c:14| Show InChI InChI=1S/C28H24N6/c1-33-19-31-17-27(33)28(22-11-9-20(15-29)10-12-22)32-34-14-13-23(16-30)26(18-34)25-8-4-6-21-5-2-3-7-24(21)25/h2-12,17,19,28,32H,13-14,18H2,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description In vitro inhibition of farnesyltransferase |
Bioorg Med Chem Lett 13: 1363-6 (2003)
BindingDB Entry DOI: 10.7270/Q24B30PD |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50135378
(5-(3-Bromo-phenyl)-6-[(4-cyano-phenyl)-(3-methyl-3...)Show SMILES Cn1cncc1C(OCc1c(cc(C#N)c(=O)n1C)-c1cccc(Br)c1)c1ccc(cc1)C#N Show InChI InChI=1S/C26H20BrN5O2/c1-31-16-30-14-23(31)25(18-8-6-17(12-28)7-9-18)34-15-24-22(19-4-3-5-21(27)10-19)11-20(13-29)26(33)32(24)2/h3-11,14,16,25H,15H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.510 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against farnesyltransferase (FT) |
Bioorg Med Chem Lett 13: 4001-5 (2003)
BindingDB Entry DOI: 10.7270/Q2H41QVX |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM17327
((2S)-2-({1-[benzyl(1,3-thiazol-5-ylmethyl)carbamoy...)Show SMILES CSCC[C@H](NC(=O)C1=C(CN(CC1)C(=O)N(Cc1cncs1)Cc1ccccc1)c1ccccc1C)C(O)=O |r,t:8| Show InChI InChI=1S/C30H34N4O4S2/c1-21-8-6-7-11-24(21)26-19-33(14-12-25(26)28(35)32-27(29(36)37)13-15-39-2)30(38)34(18-23-16-31-20-40-23)17-22-9-4-3-5-10-22/h3-11,16,20,27H,12-15,17-19H2,1-2H3,(H,32,35)(H,36,37)/t27-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.560 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Abbott Laboratories
| Assay Description The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r... |
Bioorg Med Chem Lett 13: 1359-62 (2003)
Article DOI: 10.1016/S0960-894X(03)00095-7 BindingDB Entry DOI: 10.7270/Q2QJ7FK9 |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153776
(5-((5-(((5-cyano-3'-ethoxybiphenyl-2-yl)methoxy)me...)Show SMILES CCOc1cccc(c1)-c1cc(ccc1COCc1cncn1Cc1ccc(nc1)C#N)C#N Show InChI InChI=1S/C27H23N5O2/c1-2-34-26-5-3-4-22(11-26)27-10-20(12-28)6-8-23(27)17-33-18-25-15-30-19-32(25)16-21-7-9-24(13-29)31-14-21/h3-11,14-15,19H,2,16-18H2,1H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.580 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011 BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153782
(6-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)me...)Show SMILES Cc1ccc(cc1C)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N Show InChI InChI=1S/C28H24N4O/c1-20-3-9-25(11-21(20)2)28-12-24(14-30)8-10-26(28)17-33-18-27-15-31-19-32(27)16-23-6-4-22(13-29)5-7-23/h3-12,15,19H,16-18H2,1-2H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011 BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153779
(4-((5-(((3',5-dichlorobiphenyl-2-yl)methoxy)methyl...)Show SMILES Clc1cccc(c1)-c1cc(Cl)ccc1COCc1cncn1Cc1ccc(cc1)C#N Show InChI InChI=1S/C25H19Cl2N3O/c26-22-3-1-2-20(10-22)25-11-23(27)9-8-21(25)15-31-16-24-13-29-17-30(24)14-19-6-4-18(12-28)5-7-19/h1-11,13,17H,14-16H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.620 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011 BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50126335
(6-[(R)-Amino-(4-chloro-phenyl)-(3-methyl-3H-imidaz...)Show SMILES Cn1ccnc1C(N)(c1ccc(Cl)cc1)c1ccc2n(C)c(=O)cc(-c3cccc(Cl)c3)c2c1 Show InChI InChI=1S/C27H22Cl2N4O/c1-32-13-12-31-26(32)27(30,18-6-9-20(28)10-7-18)19-8-11-24-23(15-19)22(16-25(34)33(24)2)17-4-3-5-21(29)14-17/h3-16H,30H2,1-2H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid UniChem
Patents
Similars
| MMDB Article PubMed
| n/a | n/a | 0.650 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011 BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153774
(4-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methylamin...)Show SMILES N#Cc1ccc(Cn2cncc2CNCc2ccc(C#N)c(c2)-c2cccc3ccccc23)cc1 Show InChI InChI=1S/C30H23N5/c31-15-22-8-10-23(11-9-22)20-35-21-34-19-27(35)18-33-17-24-12-13-26(16-32)30(14-24)29-7-3-5-25-4-1-2-6-28(25)29/h1-14,19,21,33H,17-18,20H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.650 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011 BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153174
(6-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)me...)Show SMILES FC(F)(F)Oc1ccc(cc1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N Show InChI InChI=1S/C27H19F3N4O2/c28-27(29,30)36-25-9-7-22(8-10-25)26-11-21(13-32)5-6-23(26)16-35-17-24-14-33-18-34(24)15-20-3-1-19(12-31)2-4-20/h1-11,14,18H,15-17H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.650 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011 BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50135372
(6-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)Show SMILES CCOc1cccc(c1)-c1cc(C#N)c(=O)n(C)c1COC(c1cncn1C)c1ccc(cc1)C#N Show InChI InChI=1S/C28H25N5O3/c1-4-35-23-7-5-6-21(12-23)24-13-22(15-30)28(34)33(3)26(24)17-36-27(25-16-31-18-32(25)2)20-10-8-19(14-29)9-11-20/h5-13,16,18,27H,4,17H2,1-3H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.670 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against farnesyltransferase (FT) |
Bioorg Med Chem Lett 13: 4001-5 (2003)
BindingDB Entry DOI: 10.7270/Q2H41QVX |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50135355
(6-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)Show SMILES Cn1cncc1C(OCc1c(cc(C#N)c(=O)n1C)-c1ccc2OC(F)(F)Oc2c1)c1ccc(cc1)C#N Show InChI InChI=1S/C27H19F2N5O4/c1-33-15-32-13-21(33)25(17-5-3-16(11-30)4-6-17)36-14-22-20(9-19(12-31)26(35)34(22)2)18-7-8-23-24(10-18)38-27(28,29)37-23/h3-10,13,15,25H,14H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.690 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against farnesyltransferase (FT) |
Bioorg Med Chem Lett 13: 4001-5 (2003)
BindingDB Entry DOI: 10.7270/Q2H41QVX |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50135368
(5-(3-Chloro-5-fluoro-phenyl)-6-[(4-cyano-phenyl)-(...)Show SMILES Cn1cncc1C(OCc1c(cc(C#N)c(=O)n1C)-c1cc(F)cc(Cl)c1)c1ccc(cc1)C#N Show InChI InChI=1S/C26H19ClFN5O2/c1-32-15-31-13-23(32)25(17-5-3-16(11-29)4-6-17)35-14-24-22(9-19(12-30)26(34)33(24)2)18-7-20(27)10-21(28)8-18/h3-10,13,15,25H,14H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against farnesyltransferase (FT) |
Bioorg Med Chem Lett 13: 4001-5 (2003)
BindingDB Entry DOI: 10.7270/Q2H41QVX |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM17328
((2S)-2-[(1-{[3-cyclohexyl-1-(1,3-thiazol-5-yl)prop...)Show SMILES CSCC[C@H](NC(=O)C1=C(CN(CC1)C(=O)OC(CCC1CCCCC1)c1cncs1)c1ccccc1C)C(O)=O |r,t:8| Show InChI InChI=1S/C31H41N3O5S2/c1-21-8-6-7-11-23(21)25-19-34(16-14-24(25)29(35)33-26(30(36)37)15-17-40-2)31(38)39-27(28-18-32-20-41-28)13-12-22-9-4-3-5-10-22/h6-8,11,18,20,22,26-27H,3-5,9-10,12-17,19H2,1-2H3,(H,33,35)(H,36,37)/t26-,27?/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.710 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Abbott Laboratories
| Assay Description The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r... |
Bioorg Med Chem Lett 13: 1359-62 (2003)
Article DOI: 10.1016/S0960-894X(03)00095-7 BindingDB Entry DOI: 10.7270/Q2QJ7FK9 |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50127315
(6-[(4-Cyano-3-naphthalen-1-yl-phenyl)-(3-methyl-3H...)Show SMILES Cn1cncc1C(OCc1ccc(cn1)C#N)c1ccc(C#N)c(c1)-c1cccc2ccccc12 Show InChI InChI=1S/C29H21N5O/c1-34-19-32-17-28(34)29(35-18-24-12-9-20(14-30)16-33-24)22-10-11-23(15-31)27(13-22)26-8-4-6-21-5-2-3-7-25(21)26/h2-13,16-17,19,29H,18H2,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.730 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against farnesyltransferase (FT) |
Bioorg Med Chem Lett 13: 4001-5 (2003)
BindingDB Entry DOI: 10.7270/Q2H41QVX |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50135364
(5-(3-Chloro-phenyl)-6-[(4-cyano-phenyl)-(3-methyl-...)Show SMILES CCn1c(COC(c2cncn2C)c2ccc(cc2)C#N)c(cc(C#N)c1=O)-c1cccc(Cl)c1 Show InChI InChI=1S/C27H22ClN5O2/c1-3-33-25(23(12-21(14-30)27(33)34)20-5-4-6-22(28)11-20)16-35-26(24-15-31-17-32(24)2)19-9-7-18(13-29)8-10-19/h4-12,15,17,26H,3,16H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.730 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against farnesyltransferase (FT) |
Bioorg Med Chem Lett 13: 4001-5 (2003)
BindingDB Entry DOI: 10.7270/Q2H41QVX |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50135377
(6-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)Show SMILES Cn1cncc1C(OCc1c(cc(C#N)c(=O)n1C)-c1ccc(OC(F)(F)F)cc1)c1ccc(cc1)C#N Show InChI InChI=1S/C27H20F3N5O3/c1-34-16-33-14-23(34)25(19-5-3-17(12-31)4-6-19)37-15-24-22(11-20(13-32)26(36)35(24)2)18-7-9-21(10-8-18)38-27(28,29)30/h3-11,14,16,25H,15H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.730 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against farnesyltransferase (FT) |
Bioorg Med Chem Lett 13: 4001-5 (2003)
BindingDB Entry DOI: 10.7270/Q2H41QVX |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50135386
(5-(3-Chloro-phenyl)-6-[(4-cyano-3-iodo-phenyl)-(3-...)Show SMILES Cn1cncc1C(OCc1c(cc(C#N)c(=O)n1C)-c1cccc(Cl)c1)c1ccc(C#N)c(I)c1 Show InChI InChI=1S/C26H19ClIN5O2/c1-32-15-31-13-23(32)25(17-6-7-18(11-29)22(28)10-17)35-14-24-21(16-4-3-5-20(27)8-16)9-19(12-30)26(34)33(24)2/h3-10,13,15,25H,14H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.75 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against farnesyltransferase (FT) |
Bioorg Med Chem Lett 13: 4001-5 (2003)
BindingDB Entry DOI: 10.7270/Q2H41QVX |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50135366
(6-[(3-Chloro-4-cyano-phenyl)-(3-methyl-3H-imidazol...)Show SMILES Cn1cncc1C(OCc1c(cc(C#N)c(=O)n1C)-c1cc(Cl)cc(Cl)c1)c1ccc(C#N)c(Cl)c1 Show InChI InChI=1S/C26H18Cl3N5O2/c1-33-14-32-12-23(33)25(15-3-4-16(10-30)22(29)8-15)36-13-24-21(7-18(11-31)26(35)34(24)2)17-5-19(27)9-20(28)6-17/h3-9,12,14,25H,13H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.770 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against farnesyltransferase (FT) |
Bioorg Med Chem Lett 13: 4001-5 (2003)
BindingDB Entry DOI: 10.7270/Q2H41QVX |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50135392
(6-[(4-Cyano-3-iodo-phenyl)-(3-methyl-3H-imidazol-4...)Show SMILES Cn1cncc1C(OCc1c(cc(C#N)c(=O)n1C)-c1cc(Cl)cc(Cl)c1)c1ccc(C#N)c(I)c1 Show InChI InChI=1S/C26H18Cl2IN5O2/c1-33-14-32-12-23(33)25(15-3-4-16(10-30)22(29)8-15)36-13-24-21(7-18(11-31)26(35)34(24)2)17-5-19(27)9-20(28)6-17/h3-9,12,14,25H,13H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.810 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against farnesyltransferase (FT) |
Bioorg Med Chem Lett 13: 4001-5 (2003)
BindingDB Entry DOI: 10.7270/Q2H41QVX |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153784
(3-(benzo[d][1,3]dioxol-4-yl)-4-(((1-(4-cyanobenzyl...)Show SMILES N#Cc1ccc(Cn2cncc2COCc2ccc(cc2-c2cccc3OCOc23)C#N)cc1 Show InChI InChI=1S/C27H20N4O3/c28-11-19-4-6-20(7-5-19)14-31-17-30-13-23(31)16-32-15-22-9-8-21(12-29)10-25(22)24-2-1-3-26-27(24)34-18-33-26/h1-10,13,17H,14-16,18H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.810 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011 BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50135394
(6-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)Show SMILES Cn1cncc1C(OCc1c(cc(C#N)c(=O)n1C)-c1cc(F)cc(F)c1)c1ccc(cc1)C#N Show InChI InChI=1S/C26H19F2N5O2/c1-32-15-31-13-23(32)25(17-5-3-16(11-29)4-6-17)35-14-24-22(9-19(12-30)26(34)33(24)2)18-7-20(27)10-21(28)8-18/h3-10,13,15,25H,14H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.840 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against farnesyltransferase (FT) |
Bioorg Med Chem Lett 13: 4001-5 (2003)
BindingDB Entry DOI: 10.7270/Q2H41QVX |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50135381
(5-(3-Chloro-phenyl)-6-[(4-cyano-phenyl)-(3-methyl-...)Show SMILES Cn1cncc1C(OCc1[nH]c(=O)c(cc1-c1cccc(Cl)c1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C25H18ClN5O2/c1-31-15-29-13-23(31)24(17-7-5-16(11-27)6-8-17)33-14-22-21(10-19(12-28)25(32)30-22)18-3-2-4-20(26)9-18/h2-10,13,15,24H,14H2,1H3,(H,30,32) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.850 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against farnesyltransferase (FT) |
Bioorg Med Chem Lett 13: 4001-5 (2003)
BindingDB Entry DOI: 10.7270/Q2H41QVX |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50135382
(6-[(3-Bromo-4-cyano-phenyl)-(3-methyl-3H-imidazol-...)Show SMILES Cn1cncc1C(OCc1c(cc(C#N)c(=O)n1C)-c1ccc(OC(F)(F)F)cc1)c1ccc(C#N)c(Br)c1 Show InChI InChI=1S/C27H19BrF3N5O3/c1-35-15-34-13-23(35)25(17-3-4-18(11-32)22(28)10-17)38-14-24-21(9-19(12-33)26(37)36(24)2)16-5-7-20(8-6-16)39-27(29,30)31/h3-10,13,15,25H,14H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.890 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against farnesyltransferase (FT) |
Bioorg Med Chem Lett 13: 4001-5 (2003)
BindingDB Entry DOI: 10.7270/Q2H41QVX |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153778
(6-((1-(4-cyano-3-(naphthalen-1-yl)benzyl)-1H-imida...)Show SMILES N#Cc1ccc(OCc2cncn2Cc2ccc(C#N)c(c2)-c2cccc3ccccc23)nc1 Show InChI InChI=1S/C28H19N5O/c29-13-21-9-11-28(32-15-21)34-18-24-16-31-19-33(24)17-20-8-10-23(14-30)27(12-20)26-7-3-5-22-4-1-2-6-25(22)26/h1-12,15-16,19H,17-18H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011 BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM17335
(1-[(2R)-2-{[(4-cyanophenyl)methyl](methyl)amino}-3...)Show SMILES CN(Cc1ccc(cc1)C#N)[C@H](Cc1cncn1C)C(=O)N1CCC(C#N)=C(C1)c1cccc2ccccc12 |r,c:28| Show InChI InChI=1S/C32H30N6O/c1-36(20-24-12-10-23(17-33)11-13-24)31(16-27-19-35-22-37(27)2)32(39)38-15-14-26(18-34)30(21-38)29-9-5-7-25-6-3-4-8-28(25)29/h3-13,19,22,31H,14-16,20-21H2,1-2H3/t31-/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.920 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Abbott Laboratories
| Assay Description The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r... |
Bioorg Med Chem Lett 13: 1359-62 (2003)
Article DOI: 10.1016/S0960-894X(03)00095-7 BindingDB Entry DOI: 10.7270/Q2QJ7FK9 |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153777
(4-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)me...)Show SMILES N#Cc1ccc(Cn2cncc2COCc2ccc(cc2-c2ccc3ccccc3c2)C#N)cc1 Show InChI InChI=1S/C30H22N4O/c31-15-22-5-7-23(8-6-22)18-34-21-33-17-29(34)20-35-19-28-10-9-24(16-32)13-30(28)27-12-11-25-3-1-2-4-26(25)14-27/h1-14,17,21H,18-20H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.920 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011 BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM17335
(1-[(2R)-2-{[(4-cyanophenyl)methyl](methyl)amino}-3...)Show SMILES CN(Cc1ccc(cc1)C#N)[C@H](Cc1cncn1C)C(=O)N1CCC(C#N)=C(C1)c1cccc2ccccc12 |r,c:28| Show InChI InChI=1S/C32H30N6O/c1-36(20-24-12-10-23(17-33)11-13-24)31(16-27-19-35-22-37(27)2)32(39)38-15-14-26(18-34)30(21-38)29-9-5-7-25-6-3-4-8-28(25)29/h3-13,19,22,31H,14-16,20-21H2,1-2H3/t31-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.920 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description In vitro inhibition of farnesyltransferase |
Bioorg Med Chem Lett 13: 1363-6 (2003)
BindingDB Entry DOI: 10.7270/Q24B30PD |
More data for this Ligand-Target Pair | |