Compile Data Set for Download or QSAR

Found 128 hits with Last Name = 'muthuppalaniappan' and Initial = 'm'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM184555 (US9150579, A1) Show SMILES CC(C)Oc1ccc(cc1F)-c1nn([C@@H](C)c2oc3ccccc3c(=O)c2-c2cccc(F)c2)c2ncnc(N)c12 |r| Show InChI InChI=1S/C31H25F2N5O3/c1-16(2)40-24-12-11-19(14-22(24)33)27-26-30(34)35-15-36-31(26)38(37-27)17(3)29-25(18-7-6-8-20(32)13-18)28(39)21-9-4-5-10-23(21)41-29/h4-17H,1-3H3,(H2,34,35,36)/t17-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13.8	n/a	n/a	n/a	n/a	n/a	25
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description The homogenous time resolved fluorescence (HTRF) assay allows detection of 3,4,5-triphosphate (PIP3) formed as a result of phosphorylation of phosp...				US Patent US9150579 (2015) BindingDB Entry DOI: 10.7270/Q26T0KD5
					More data for this Ligand-Target Pair
EF-hand calcium-binding domain-containing protein 4B (Homo sapiens (Human))	BDBM141416 (US10668051, Compound Example 67 | US8921364, 67) Show SMILES Fc1cnccc1C(=O)Nc1ccc(cc1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C19H14F4N4O/c20-15-10-24-8-7-14(15)18(28)25-12-3-5-13(6-4-12)27-16(11-1-2-11)9-17(26-27)19(21,22)23/h3-11H,1-2H2,(H,25,28)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	20.4	n/a	n/a	n/a	n/a	n/a	37
Rhizen Pharmaceuticals SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu...				US Patent US8921364 (2014) BindingDB Entry DOI: 10.7270/Q2N58K3N
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel protein 1 (Homo sapiens (Human))	BDBM141416 (US10668051, Compound Example 67 | US8921364, 67) Show SMILES Fc1cnccc1C(=O)Nc1ccc(cc1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C19H14F4N4O/c20-15-10-24-8-7-14(15)18(28)25-12-3-5-13(6-4-12)27-16(11-1-2-11)9-17(26-27)19(21,22)23/h3-11H,1-2H2,(H,25,28)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	20.4	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020) BindingDB Entry DOI: 10.7270/Q2V40Z7G
					More data for this Ligand-Target Pair
EF-hand calcium-binding domain-containing protein 4B (Homo sapiens (Human))	BDBM141426 (US10668051, Compound Example 84 | US8921364, 84) Show SMILES Cc1oncc1C(=O)Nc1ccc(c(F)c1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C18H14F4N4O2/c1-9-12(8-23-28-9)17(27)24-11-4-5-14(13(19)6-11)26-15(10-2-3-10)7-16(25-26)18(20,21)22/h4-8,10H,2-3H2,1H3,(H,24,27)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	20.8	n/a	n/a	n/a	n/a	n/a	37
Rhizen Pharmaceuticals SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu...				US Patent US8921364 (2014) BindingDB Entry DOI: 10.7270/Q2N58K3N
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel protein 1 (Homo sapiens (Human))	BDBM141426 (US10668051, Compound Example 84 | US8921364, 84) Show SMILES Cc1oncc1C(=O)Nc1ccc(c(F)c1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C18H14F4N4O2/c1-9-12(8-23-28-9)17(27)24-11-4-5-14(13(19)6-11)26-15(10-2-3-10)7-16(25-26)18(20,21)22/h4-8,10H,2-3H2,1H3,(H,24,27)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	20.8	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020) BindingDB Entry DOI: 10.7270/Q2V40Z7G
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM184556 (US9150579, B1) Show SMILES CC(C)Oc1ccc(cc1F)-c1nn([C@@H](C)c2oc3ccc(F)cc3c(=O)c2-c2cccc(F)c2)c2ncnc(N)c12 |r| Show InChI InChI=1S/C31H24F3N5O3/c1-15(2)41-24-9-7-18(12-22(24)34)27-26-30(35)36-14-37-31(26)39(38-27)16(3)29-25(17-5-4-6-19(32)11-17)28(40)21-13-20(33)8-10-23(21)42-29/h4-16H,1-3H3,(H2,35,36,37)/t16-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	US Patent	n/a	n/a	22.3	n/a	n/a	n/a	n/a	n/a	25
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description The homogenous time resolved fluorescence (HTRF) assay allows detection of 3,4,5-triphosphate (PIP3) formed as a result of phosphorylation of phosp...				US Patent US9150579 (2015) BindingDB Entry DOI: 10.7270/Q26T0KD5
					More data for this Ligand-Target Pair
EF-hand calcium-binding domain-containing protein 4B (Homo sapiens (Human))	BDBM141438 (US10668051, Compound Example 104 | US8921364, 104) Show SMILES Cc1ccccc1C(=O)Nc1ccc(nc1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C20H17F3N4O/c1-12-4-2-3-5-15(12)19(28)25-14-8-9-18(24-11-14)27-16(13-6-7-13)10-17(26-27)20(21,22)23/h2-5,8-11,13H,6-7H2,1H3,(H,25,28)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	23.0	n/a	n/a	n/a	n/a	n/a	37
Rhizen Pharmaceuticals SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu...				US Patent US8921364 (2014) BindingDB Entry DOI: 10.7270/Q2N58K3N
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel protein 1 (Homo sapiens (Human))	BDBM141438 (US10668051, Compound Example 104 | US8921364, 104) Show SMILES Cc1ccccc1C(=O)Nc1ccc(nc1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C20H17F3N4O/c1-12-4-2-3-5-15(12)19(28)25-14-8-9-18(24-11-14)27-16(13-6-7-13)10-17(26-27)20(21,22)23/h2-5,8-11,13H,6-7H2,1H3,(H,25,28)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020) BindingDB Entry DOI: 10.7270/Q2V40Z7G
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM184554 (US9150579, B) Show SMILES CC(C)Oc1ccc(cc1F)-c1nn(C(C)c2oc3ccc(F)cc3c(=O)c2-c2cccc(F)c2)c2ncnc(N)c12 Show InChI InChI=1S/C31H24F3N5O3/c1-15(2)41-24-9-7-18(12-22(24)34)27-26-30(35)36-14-37-31(26)39(38-27)16(3)29-25(17-5-4-6-19(32)11-17)28(40)21-13-20(33)8-10-23(21)42-29/h4-16H,1-3H3,(H2,35,36,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	US Patent	n/a	n/a	24.9	n/a	n/a	n/a	n/a	n/a	25
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description The homogenous time resolved fluorescence (HTRF) assay allows detection of 3,4,5-triphosphate (PIP3) formed as a result of phosphorylation of phosp...				US Patent US9150579 (2015) BindingDB Entry DOI: 10.7270/Q26T0KD5
					More data for this Ligand-Target Pair
EF-hand calcium-binding domain-containing protein 4B (Homo sapiens (Human))	BDBM141428 (US10668051, Compound Example 87 | US8921364, 87) Show SMILES Fc1cccc(C(=O)Nc2ccc(c(F)c2)-n2nc(cc2C2CC2)C(F)(F)F)c1F Show InChI InChI=1S/C20H13F6N3O/c21-13-3-1-2-12(18(13)23)19(30)27-11-6-7-15(14(22)8-11)29-16(10-4-5-10)9-17(28-29)20(24,25)26/h1-3,6-10H,4-5H2,(H,27,30)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	32.6	n/a	n/a	n/a	n/a	n/a	37
Rhizen Pharmaceuticals SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu...				US Patent US8921364 (2014) BindingDB Entry DOI: 10.7270/Q2N58K3N
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel protein 1 (Homo sapiens (Human))	BDBM141428 (US10668051, Compound Example 87 | US8921364, 87) Show SMILES Fc1cccc(C(=O)Nc2ccc(c(F)c2)-n2nc(cc2C2CC2)C(F)(F)F)c1F Show InChI InChI=1S/C20H13F6N3O/c21-13-3-1-2-12(18(13)23)19(30)27-11-6-7-15(14(22)8-11)29-16(10-4-5-10)9-17(28-29)20(24,25)26/h1-3,6-10H,4-5H2,(H,27,30)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	32.6	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020) BindingDB Entry DOI: 10.7270/Q2V40Z7G
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel protein 1 (Homo sapiens (Human))	BDBM141421 (US10668051, Compound Example 78 | US8921364, 78) Show SMILES Cc1ncsc1NC(=O)c1ccc(cc1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C18H15F3N4OS/c1-10-17(27-9-22-10)23-16(26)12-4-6-13(7-5-12)25-14(11-2-3-11)8-15(24-25)18(19,20)21/h4-9,11H,2-3H2,1H3,(H,23,26)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	34.1	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020) BindingDB Entry DOI: 10.7270/Q2V40Z7G
					More data for this Ligand-Target Pair
EF-hand calcium-binding domain-containing protein 4B (Homo sapiens (Human))	BDBM141421 (US10668051, Compound Example 78 | US8921364, 78) Show SMILES Cc1ncsc1NC(=O)c1ccc(cc1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C18H15F3N4OS/c1-10-17(27-9-22-10)23-16(26)12-4-6-13(7-5-12)25-14(11-2-3-11)8-15(24-25)18(19,20)21/h4-9,11H,2-3H2,1H3,(H,23,26)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	34.1	n/a	n/a	n/a	n/a	n/a	37
Rhizen Pharmaceuticals SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu...				US Patent US8921364 (2014) BindingDB Entry DOI: 10.7270/Q2N58K3N
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel protein 1 (Homo sapiens (Human))	BDBM141424 (US10668051, Compound Example 82 | US8921364, 82) Show SMILES Cc1nnsc1C(=O)Nc1ccc(c(F)c1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C17H13F4N5OS/c1-8-15(28-25-23-8)16(27)22-10-4-5-12(11(18)6-10)26-13(9-2-3-9)7-14(24-26)17(19,20)21/h4-7,9H,2-3H2,1H3,(H,22,27)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	35.7	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020) BindingDB Entry DOI: 10.7270/Q2V40Z7G
					More data for this Ligand-Target Pair
EF-hand calcium-binding domain-containing protein 4B (Homo sapiens (Human))	BDBM141424 (US10668051, Compound Example 82 | US8921364, 82) Show SMILES Cc1nnsc1C(=O)Nc1ccc(c(F)c1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C17H13F4N5OS/c1-8-15(28-25-23-8)16(27)22-10-4-5-12(11(18)6-10)26-13(9-2-3-9)7-14(24-26)17(19,20)21/h4-7,9H,2-3H2,1H3,(H,22,27)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	35.7	n/a	n/a	n/a	n/a	n/a	37
Rhizen Pharmaceuticals SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu...				US Patent US8921364 (2014) BindingDB Entry DOI: 10.7270/Q2N58K3N
					More data for this Ligand-Target Pair
EF-hand calcium-binding domain-containing protein 4B (Homo sapiens (Human))	BDBM141396 (US10668051, Compound Example 7 | US8921364, 7) Show SMILES Cc1ccccc1C(=O)Nc1ccc(cc1)-n1nc(cc1C1CC1)C1CC1 Show InChI InChI=1S/C23H23N3O/c1-15-4-2-3-5-20(15)23(27)24-18-10-12-19(13-11-18)26-22(17-8-9-17)14-21(25-26)16-6-7-16/h2-5,10-14,16-17H,6-9H2,1H3,(H,24,27)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	36.4	n/a	n/a	n/a	n/a	n/a	37
Rhizen Pharmaceuticals SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu...				US Patent US8921364 (2014) BindingDB Entry DOI: 10.7270/Q2N58K3N
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel protein 1 (Homo sapiens (Human))	BDBM141396 (US10668051, Compound Example 7 | US8921364, 7) Show SMILES Cc1ccccc1C(=O)Nc1ccc(cc1)-n1nc(cc1C1CC1)C1CC1 Show InChI InChI=1S/C23H23N3O/c1-15-4-2-3-5-20(15)23(27)24-18-10-12-19(13-11-18)26-22(17-8-9-17)14-21(25-26)16-6-7-16/h2-5,10-14,16-17H,6-9H2,1H3,(H,24,27)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	36.4	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020) BindingDB Entry DOI: 10.7270/Q2V40Z7G
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM184559 (US9150579, A) Show SMILES CC(C)Oc1ccc(cc1F)-c1nn(C(C)c2oc3ccccc3c(=O)c2-c2cccc(F)c2)c2ncnc(N)c12 Show InChI InChI=1S/C31H25F2N5O3/c1-16(2)40-24-12-11-19(14-22(24)33)27-26-30(34)35-15-36-31(26)38(37-27)17(3)29-25(18-7-6-8-20(32)13-18)28(39)21-9-4-5-10-23(21)41-29/h4-17H,1-3H3,(H2,34,35,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	37.3	n/a	n/a	n/a	n/a	n/a	25
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description The homogenous time resolved fluorescence (HTRF) assay allows detection of 3,4,5-triphosphate (PIP3) formed as a result of phosphorylation of phosp...				US Patent US9150579 (2015) BindingDB Entry DOI: 10.7270/Q26T0KD5
					More data for this Ligand-Target Pair
EF-hand calcium-binding domain-containing protein 4B (Homo sapiens (Human))	BDBM141444 (US10668051, Compound Example 114 | US8921364, 114) Show SMILES Fc1cnccc1C(=O)Nc1ccc(nc1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C18H13F4N5O/c19-13-9-23-6-5-12(13)17(28)25-11-3-4-16(24-8-11)27-14(10-1-2-10)7-15(26-27)18(20,21)22/h3-10H,1-2H2,(H,25,28)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	37.6	n/a	n/a	n/a	n/a	n/a	37
Rhizen Pharmaceuticals SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu...				US Patent US8921364 (2014) BindingDB Entry DOI: 10.7270/Q2N58K3N
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel protein 1 (Homo sapiens (Human))	BDBM141444 (US10668051, Compound Example 114 | US8921364, 114) Show SMILES Fc1cnccc1C(=O)Nc1ccc(nc1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C18H13F4N5O/c19-13-9-23-6-5-12(13)17(28)25-11-3-4-16(24-8-11)27-14(10-1-2-10)7-15(26-27)18(20,21)22/h3-10H,1-2H2,(H,25,28)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	37.6	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020) BindingDB Entry DOI: 10.7270/Q2V40Z7G
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel protein 1 (Homo sapiens (Human))	BDBM152937 (US8993612, 20) Show SMILES FC(F)(F)c1cc(C2CC2)n(n1)-c1ccc(NC(=O)Cn2nnc3ccccc23)cc1 Show InChI InChI=1S/C21H17F3N6O/c22-21(23,24)19-11-18(13-5-6-13)30(27-19)15-9-7-14(8-10-15)25-20(31)12-29-17-4-2-1-3-16(17)26-28-29/h1-4,7-11,13H,5-6,12H2,(H,25,31)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	39.2	n/a	n/a	n/a	n/a	n/a	37
Rhizen Pharmaceuticals SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu...				US Patent US8993612 (2015) BindingDB Entry DOI: 10.7270/Q2CN72NK
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel protein 1 (Homo sapiens (Human))	BDBM141442 (US10668051, Compound Example 111 | US8921364, 111) Show SMILES FC(F)(F)c1cc(C2CC2)n(n1)-c1ccc(NC(=O)c2cccnc2)cn1 Show InChI InChI=1S/C18H14F3N5O/c19-18(20,21)15-8-14(11-3-4-11)26(25-15)16-6-5-13(10-23-16)24-17(27)12-2-1-7-22-9-12/h1-2,5-11H,3-4H2,(H,24,27)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	47.2	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020) BindingDB Entry DOI: 10.7270/Q2V40Z7G
					More data for this Ligand-Target Pair
EF-hand calcium-binding domain-containing protein 4B (Homo sapiens (Human))	BDBM141442 (US10668051, Compound Example 111 | US8921364, 111) Show SMILES FC(F)(F)c1cc(C2CC2)n(n1)-c1ccc(NC(=O)c2cccnc2)cn1 Show InChI InChI=1S/C18H14F3N5O/c19-18(20,21)15-8-14(11-3-4-11)26(25-15)16-6-5-13(10-23-16)24-17(27)12-2-1-7-22-9-12/h1-2,5-11H,3-4H2,(H,24,27)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	47.2	n/a	n/a	n/a	n/a	n/a	37
Rhizen Pharmaceuticals SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu...				US Patent US8921364 (2014) BindingDB Entry DOI: 10.7270/Q2N58K3N
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel protein 1 (Homo sapiens (Human))	BDBM141419 (US10668051, Compound Example 74 | US8921364, 74) Show SMILES Cc1ncsc1CNc1ccc(cc1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C18H17F3N4S/c1-11-16(26-10-23-11)9-22-13-4-6-14(7-5-13)25-15(12-2-3-12)8-17(24-25)18(19,20)21/h4-8,10,12,22H,2-3,9H2,1H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	48	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020) BindingDB Entry DOI: 10.7270/Q2V40Z7G
					More data for this Ligand-Target Pair
EF-hand calcium-binding domain-containing protein 4B (Homo sapiens (Human))	BDBM141419 (US10668051, Compound Example 74 | US8921364, 74) Show SMILES Cc1ncsc1CNc1ccc(cc1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C18H17F3N4S/c1-11-16(26-10-23-11)9-22-13-4-6-14(7-5-13)25-15(12-2-3-12)8-17(24-25)18(19,20)21/h4-8,10,12,22H,2-3,9H2,1H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	48.0	n/a	n/a	n/a	n/a	n/a	37
Rhizen Pharmaceuticals SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu...				US Patent US8921364 (2014) BindingDB Entry DOI: 10.7270/Q2N58K3N
					More data for this Ligand-Target Pair
EF-hand calcium-binding domain-containing protein 4B (Homo sapiens (Human))	BDBM141425 (US10668051, Compound Example 83 | US8921364, 83) Show SMILES Cc1ncsc1C(=O)Nc1ccc(c(F)c1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C18H14F4N4OS/c1-9-16(28-8-23-9)17(27)24-11-4-5-13(12(19)6-11)26-14(10-2-3-10)7-15(25-26)18(20,21)22/h4-8,10H,2-3H2,1H3,(H,24,27)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	48.2	n/a	n/a	n/a	n/a	n/a	37
Rhizen Pharmaceuticals SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu...				US Patent US8921364 (2014) BindingDB Entry DOI: 10.7270/Q2N58K3N
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel protein 1 (Homo sapiens (Human))	BDBM141425 (US10668051, Compound Example 83 | US8921364, 83) Show SMILES Cc1ncsc1C(=O)Nc1ccc(c(F)c1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C18H14F4N4OS/c1-9-16(28-8-23-9)17(27)24-11-4-5-13(12(19)6-11)26-14(10-2-3-10)7-15(25-26)18(20,21)22/h4-8,10H,2-3H2,1H3,(H,24,27)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	48.2	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020) BindingDB Entry DOI: 10.7270/Q2V40Z7G
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel protein 1 (Homo sapiens (Human))	BDBM141418 (US10668051, Compound Example 72 | US8921364, 72) Show SMILES FC(F)(F)c1cc(C2CC2)n(n1)-c1ccc(NC(=O)Cc2cccnc2)cc1 Show InChI InChI=1S/C20H17F3N4O/c21-20(22,23)18-11-17(14-3-4-14)27(26-18)16-7-5-15(6-8-16)25-19(28)10-13-2-1-9-24-12-13/h1-2,5-9,11-12,14H,3-4,10H2,(H,25,28)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	48.2	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020) BindingDB Entry DOI: 10.7270/Q2V40Z7G
					More data for this Ligand-Target Pair
EF-hand calcium-binding domain-containing protein 4B (Homo sapiens (Human))	BDBM141418 (US10668051, Compound Example 72 | US8921364, 72) Show SMILES FC(F)(F)c1cc(C2CC2)n(n1)-c1ccc(NC(=O)Cc2cccnc2)cc1 Show InChI InChI=1S/C20H17F3N4O/c21-20(22,23)18-11-17(14-3-4-14)27(26-18)16-7-5-15(6-8-16)25-19(28)10-13-2-1-9-24-12-13/h1-2,5-9,11-12,14H,3-4,10H2,(H,25,28)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	48.2	n/a	n/a	n/a	n/a	n/a	37
Rhizen Pharmaceuticals SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu...				US Patent US8921364 (2014) BindingDB Entry DOI: 10.7270/Q2N58K3N
					More data for this Ligand-Target Pair
EF-hand calcium-binding domain-containing protein 4B (Homo sapiens (Human))	BDBM141441 (US10668051, Compound Example 108 | US8921364, 108) Show SMILES Fc1cccc(F)c1C(=O)Nc1ccc(nc1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C19H13F5N4O/c20-12-2-1-3-13(21)17(12)18(29)26-11-6-7-16(25-9-11)28-14(10-4-5-10)8-15(27-28)19(22,23)24/h1-3,6-10H,4-5H2,(H,26,29)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	50.6	n/a	n/a	n/a	n/a	n/a	37
Rhizen Pharmaceuticals SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu...				US Patent US8921364 (2014) BindingDB Entry DOI: 10.7270/Q2N58K3N
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel protein 1 (Homo sapiens (Human))	BDBM141441 (US10668051, Compound Example 108 | US8921364, 108) Show SMILES Fc1cccc(F)c1C(=O)Nc1ccc(nc1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C19H13F5N4O/c20-12-2-1-3-13(21)17(12)18(29)26-11-6-7-16(25-9-11)28-14(10-4-5-10)8-15(27-28)19(22,23)24/h1-3,6-10H,4-5H2,(H,26,29)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	50.6	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020) BindingDB Entry DOI: 10.7270/Q2V40Z7G
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel protein 1 (Homo sapiens (Human))	BDBM152932 (US8993612, 6) Show SMILES O=C(Cn1nnc2ccccc12)Nc1ccc(cc1)-n1nc(cc1C1CC1)C1CC1 Show InChI InChI=1S/C23H22N6O/c30-23(14-28-21-4-2-1-3-19(21)25-27-28)24-17-9-11-18(12-10-17)29-22(16-7-8-16)13-20(26-29)15-5-6-15/h1-4,9-13,15-16H,5-8,14H2,(H,24,30)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	51.3	n/a	n/a	n/a	n/a	n/a	37
Rhizen Pharmaceuticals SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu...				US Patent US8993612 (2015) BindingDB Entry DOI: 10.7270/Q2CN72NK
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel protein 1 (Homo sapiens (Human))	BDBM141448 (US10668051, Compound Example 126 | US8921364, 126) Show SMILES Cc1ncsc1C(=O)Nc1ccc(cc1)-n1nc(cc1C(F)F)C(F)(F)F Show InChI InChI=1S/C16H11F5N4OS/c1-8-13(27-7-22-8)15(26)23-9-2-4-10(5-3-9)25-11(14(17)18)6-12(24-25)16(19,20)21/h2-7,14H,1H3,(H,23,26)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	52.6	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020) BindingDB Entry DOI: 10.7270/Q2V40Z7G
					More data for this Ligand-Target Pair
EF-hand calcium-binding domain-containing protein 4B (Homo sapiens (Human))	BDBM141448 (US10668051, Compound Example 126 | US8921364, 126) Show SMILES Cc1ncsc1C(=O)Nc1ccc(cc1)-n1nc(cc1C(F)F)C(F)(F)F Show InChI InChI=1S/C16H11F5N4OS/c1-8-13(27-7-22-8)15(26)23-9-2-4-10(5-3-9)25-11(14(17)18)6-12(24-25)16(19,20)21/h2-7,14H,1H3,(H,23,26)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	52.6	n/a	n/a	n/a	n/a	n/a	37
Rhizen Pharmaceuticals SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu...				US Patent US8921364 (2014) BindingDB Entry DOI: 10.7270/Q2N58K3N
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel protein 1 (Homo sapiens (Human))	BDBM152936 (US8993612, 18) Show SMILES FC(F)(F)c1cc(C2CC2)n(n1)-c1ccc(NC(=O)c2ccc3nccnc3c2)cc1 Show InChI InChI=1S/C22H16F3N5O/c23-22(24,25)20-12-19(13-1-2-13)30(29-20)16-6-4-15(5-7-16)28-21(31)14-3-8-17-18(11-14)27-10-9-26-17/h3-13H,1-2H2,(H,28,31)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	53.4	n/a	n/a	n/a	n/a	n/a	37
Rhizen Pharmaceuticals SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu...				US Patent US8993612 (2015) BindingDB Entry DOI: 10.7270/Q2CN72NK
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel protein 1 (Homo sapiens (Human))	BDBM141439 (US10668051, Compound Example 106 | US8921364, 106) Show SMILES Fc1ccccc1C(=O)Nc1ccc(nc1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C19H14F4N4O/c20-14-4-2-1-3-13(14)18(28)25-12-7-8-17(24-10-12)27-15(11-5-6-11)9-16(26-27)19(21,22)23/h1-4,7-11H,5-6H2,(H,25,28)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020) BindingDB Entry DOI: 10.7270/Q2V40Z7G
					More data for this Ligand-Target Pair
EF-hand calcium-binding domain-containing protein 4B (Homo sapiens (Human))	BDBM141439 (US10668051, Compound Example 106 | US8921364, 106) Show SMILES Fc1ccccc1C(=O)Nc1ccc(nc1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C19H14F4N4O/c20-14-4-2-1-3-13(14)18(28)25-12-7-8-17(24-10-12)27-15(11-5-6-11)9-16(26-27)19(21,22)23/h1-4,7-11H,5-6H2,(H,25,28)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	37
Rhizen Pharmaceuticals SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu...				US Patent US8921364 (2014) BindingDB Entry DOI: 10.7270/Q2N58K3N
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel protein 1 (Homo sapiens (Human))	BDBM141402 (US10668051, Compound Example 28 | US8921364, 28) Show SMILES Cc1nnsc1C(=O)Nc1ccc(c(F)c1)-n1nc(cc1C1CC1)C1CC1 Show InChI InChI=1S/C19H18FN5OS/c1-10-18(27-24-22-10)19(26)21-13-6-7-16(14(20)8-13)25-17(12-4-5-12)9-15(23-25)11-2-3-11/h6-9,11-12H,2-5H2,1H3,(H,21,26)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	60.3	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020) BindingDB Entry DOI: 10.7270/Q2V40Z7G
					More data for this Ligand-Target Pair
EF-hand calcium-binding domain-containing protein 4B (Homo sapiens (Human))	BDBM141402 (US10668051, Compound Example 28 | US8921364, 28) Show SMILES Cc1nnsc1C(=O)Nc1ccc(c(F)c1)-n1nc(cc1C1CC1)C1CC1 Show InChI InChI=1S/C19H18FN5OS/c1-10-18(27-24-22-10)19(26)21-13-6-7-16(14(20)8-13)25-17(12-4-5-12)9-15(23-25)11-2-3-11/h6-9,11-12H,2-5H2,1H3,(H,21,26)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	60.3	n/a	n/a	n/a	n/a	n/a	37
Rhizen Pharmaceuticals SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu...				US Patent US8921364 (2014) BindingDB Entry DOI: 10.7270/Q2N58K3N
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel protein 1 (Homo sapiens (Human))	BDBM141393 (US10668051, Compound Example 1 | US8921364, 1) Show SMILES Cc1nnsc1C(=O)Nc1ccc(cc1)-n1nc(cc1C1CC1)C1CC1 Show InChI InChI=1S/C19H19N5OS/c1-11-18(26-23-21-11)19(25)20-14-6-8-15(9-7-14)24-17(13-4-5-13)10-16(22-24)12-2-3-12/h6-10,12-13H,2-5H2,1H3,(H,20,25)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	62.4	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020) BindingDB Entry DOI: 10.7270/Q2V40Z7G
					More data for this Ligand-Target Pair
EF-hand calcium-binding domain-containing protein 4B (Homo sapiens (Human))	BDBM141393 (US10668051, Compound Example 1 | US8921364, 1) Show SMILES Cc1nnsc1C(=O)Nc1ccc(cc1)-n1nc(cc1C1CC1)C1CC1 Show InChI InChI=1S/C19H19N5OS/c1-11-18(26-23-21-11)19(25)20-14-6-8-15(9-7-14)24-17(13-4-5-13)10-16(22-24)12-2-3-12/h6-10,12-13H,2-5H2,1H3,(H,20,25)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	62.4	n/a	n/a	n/a	n/a	n/a	37
Rhizen Pharmaceuticals SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu...				US Patent US8921364 (2014) BindingDB Entry DOI: 10.7270/Q2N58K3N
					More data for this Ligand-Target Pair
EF-hand calcium-binding domain-containing protein 4B (Homo sapiens (Human))	BDBM141443 (US10668051, Compound Example 113 | US8921364, 113) Show SMILES FC(F)(F)c1cc(C2CC2)n(n1)-c1ccc(NC(=O)c2ccncc2)cn1 Show InChI InChI=1S/C18H14F3N5O/c19-18(20,21)15-9-14(11-1-2-11)26(25-15)16-4-3-13(10-23-16)24-17(27)12-5-7-22-8-6-12/h3-11H,1-2H2,(H,24,27)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	62.6	n/a	n/a	n/a	n/a	n/a	37
Rhizen Pharmaceuticals SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu...				US Patent US8921364 (2014) BindingDB Entry DOI: 10.7270/Q2N58K3N
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel protein 1 (Homo sapiens (Human))	BDBM141443 (US10668051, Compound Example 113 | US8921364, 113) Show SMILES FC(F)(F)c1cc(C2CC2)n(n1)-c1ccc(NC(=O)c2ccncc2)cn1 Show InChI InChI=1S/C18H14F3N5O/c19-18(20,21)15-9-14(11-1-2-11)26(25-15)16-4-3-13(10-23-16)24-17(27)12-5-7-22-8-6-12/h3-11H,1-2H2,(H,24,27)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	62.6	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020) BindingDB Entry DOI: 10.7270/Q2V40Z7G
					More data for this Ligand-Target Pair
EF-hand calcium-binding domain-containing protein 4B (Homo sapiens (Human))	BDBM141412 (US10668051, Compound Example 56 | US8921364, 56) Show SMILES Cc1oncc1C(=O)Nc1ccc(cc1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C18H15F3N4O2/c1-10-14(9-22-27-10)17(26)23-12-4-6-13(7-5-12)25-15(11-2-3-11)8-16(24-25)18(19,20)21/h4-9,11H,2-3H2,1H3,(H,23,26)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	63.2	n/a	n/a	n/a	n/a	n/a	37
Rhizen Pharmaceuticals SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu...				US Patent US8921364 (2014) BindingDB Entry DOI: 10.7270/Q2N58K3N
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel protein 1 (Homo sapiens (Human))	BDBM141412 (US10668051, Compound Example 56 | US8921364, 56) Show SMILES Cc1oncc1C(=O)Nc1ccc(cc1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C18H15F3N4O2/c1-10-14(9-22-27-10)17(26)23-12-4-6-13(7-5-12)25-15(11-2-3-11)8-16(24-25)18(19,20)21/h4-9,11H,2-3H2,1H3,(H,23,26)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	63.2	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020) BindingDB Entry DOI: 10.7270/Q2V40Z7G
					More data for this Ligand-Target Pair
EF-hand calcium-binding domain-containing protein 4B (Homo sapiens (Human))	BDBM141409 (US10668051, Compound Example 49 | US8921364, 49) Show SMILES FC(F)(F)c1cc(C2CC2)n(n1)-c1ccc(NC(=O)c2c(Cl)cncc2Cl)cc1 Show InChI InChI=1S/C19H13Cl2F3N4O/c20-13-8-25-9-14(21)17(13)18(29)26-11-3-5-12(6-4-11)28-15(10-1-2-10)7-16(27-28)19(22,23)24/h3-10H,1-2H2,(H,26,29)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	65.5	n/a	n/a	n/a	n/a	n/a	37
Rhizen Pharmaceuticals SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu...				US Patent US8921364 (2014) BindingDB Entry DOI: 10.7270/Q2N58K3N
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel protein 1 (Homo sapiens (Human))	BDBM141409 (US10668051, Compound Example 49 | US8921364, 49) Show SMILES FC(F)(F)c1cc(C2CC2)n(n1)-c1ccc(NC(=O)c2c(Cl)cncc2Cl)cc1 Show InChI InChI=1S/C19H13Cl2F3N4O/c20-13-8-25-9-14(21)17(13)18(29)26-11-3-5-12(6-4-11)28-15(10-1-2-10)7-16(27-28)19(22,23)24/h3-10H,1-2H2,(H,26,29)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	65.5	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020) BindingDB Entry DOI: 10.7270/Q2V40Z7G
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel protein 1 (Homo sapiens (Human))	BDBM141440 (US10668051, Compound Example 107 | US8921364, 107) Show SMILES Fc1cccc(C(=O)Nc2ccc(nc2)-n2nc(cc2C2CC2)C(F)(F)F)c1F Show InChI InChI=1S/C19H13F5N4O/c20-13-3-1-2-12(17(13)21)18(29)26-11-6-7-16(25-9-11)28-14(10-4-5-10)8-15(27-28)19(22,23)24/h1-3,6-10H,4-5H2,(H,26,29)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	70.3	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020) BindingDB Entry DOI: 10.7270/Q2V40Z7G
					More data for this Ligand-Target Pair
EF-hand calcium-binding domain-containing protein 4B (Homo sapiens (Human))	BDBM141440 (US10668051, Compound Example 107 | US8921364, 107) Show SMILES Fc1cccc(C(=O)Nc2ccc(nc2)-n2nc(cc2C2CC2)C(F)(F)F)c1F Show InChI InChI=1S/C19H13F5N4O/c20-13-3-1-2-12(17(13)21)18(29)26-11-6-7-16(25-9-11)28-14(10-4-5-10)8-15(27-28)19(22,23)24/h1-3,6-10H,4-5H2,(H,26,29)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	70.3	n/a	n/a	n/a	n/a	n/a	37
Rhizen Pharmaceuticals SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu...				US Patent US8921364 (2014) BindingDB Entry DOI: 10.7270/Q2N58K3N
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel protein 1 (Homo sapiens (Human))	BDBM141411 (US10668051, Compound Example 53 | US8921364, 53) Show SMILES Cc1ncsc1C(=O)Nc1ccc(cc1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C18H15F3N4OS/c1-10-16(27-9-22-10)17(26)23-12-4-6-13(7-5-12)25-14(11-2-3-11)8-15(24-25)18(19,20)21/h4-9,11H,2-3H2,1H3,(H,23,26)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	72	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020) BindingDB Entry DOI: 10.7270/Q2V40Z7G
					More data for this Ligand-Target Pair

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