Compile Data Set for Download or QSAR

Found 73 hits Enz. Inhib. hit(s) with all data for entry = 50032108   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50324585 (CHEMBL1215022 | N-(4-(1H-Pyrazol-4-yl)phenyl)-2-am...) Show SMILES NC(C(=O)Nc1ccc(cc1)-c1cn[nH]c1)c1ccc(Cl)cc1 Show InChI InChI=1S/C17H15ClN4O/c18-14-5-1-12(2-6-14)16(19)17(23)22-15-7-3-11(4-8-15)13-9-20-21-10-13/h1-10,16H,19H2,(H,20,21)(H,22,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50324574 ((R)-6-Methoxy-N-(2-((1-methylpiperidin-4-yl)methox...) Show SMILES COc1ccc2CN[C@H](Cc2c1)C(=O)Nc1ccc(cc1OCC1CCN(C)CC1)-c1cn[nH]c1 |r| Show InChI InChI=1S/C27H33N5O3/c1-32-9-7-18(8-10-32)17-35-26-13-19(22-15-29-30-16-22)4-6-24(26)31-27(33)25-12-21-11-23(34-2)5-3-20(21)14-28-25/h3-6,11,13,15-16,18,25,28H,7-10,12,14,17H2,1-2H3,(H,29,30)(H,31,33)/t25-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50324592 ((R)-N-(2-(2-(Dimethylamino)ethoxy)-5-fluoro-4-(1H-...) Show SMILES CCN1Cc2ccccc2C[C@@H]1C(=O)Nc1cc(F)c(cc1OCCN(C)C)-c1cn[nH]c1 |r| Show InChI InChI=1S/C25H30FN5O2/c1-4-31-16-18-8-6-5-7-17(18)11-23(31)25(32)29-22-13-21(26)20(19-14-27-28-15-19)12-24(22)33-10-9-30(2)3/h5-8,12-15,23H,4,9-11,16H2,1-3H3,(H,27,28)(H,29,32)/t23-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50324604 (CHEMBL1215021 | N-(4-(1H-Pyrazol-4-yl)phenyl)-2-am...) Show SMILES NC(Cc1ccc(Cl)cc1)C(=O)Nc1ccc(cc1)-c1cn[nH]c1 Show InChI InChI=1S/C18H17ClN4O/c19-15-5-1-12(2-6-15)9-17(20)18(24)23-16-7-3-13(4-8-16)14-10-21-22-11-14/h1-8,10-11,17H,9,20H2,(H,21,22)(H,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50324602 ((R)-6-Methoxy-N-(2-(1-methylpiperidin-4-yloxy)-4-(...) Show SMILES COc1ccc2CN[C@H](Cc2c1)C(=O)Nc1ccc(cc1OC1CCN(C)CC1)-c1cn[nH]c1 |r| Show InChI InChI=1S/C26H31N5O3/c1-31-9-7-21(8-10-31)34-25-13-17(20-15-28-29-16-20)4-6-23(25)30-26(32)24-12-19-11-22(33-2)5-3-18(19)14-27-24/h3-6,11,13,15-16,21,24,27H,7-10,12,14H2,1-2H3,(H,28,29)(H,30,32)/t24-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50324605 ((R)-N-(2-(2-(Dimethylamino)ethoxy)-5-fluoro-4-(1H-...) Show SMILES COc1ccc2CN[C@H](Cc2c1)C(=O)Nc1cc(F)c(cc1OCCN(C)C)-c1cn[nH]c1 |r| Show InChI InChI=1S/C24H28FN5O3/c1-30(2)6-7-33-23-10-19(17-13-27-28-14-17)20(25)11-21(23)29-24(31)22-9-16-8-18(32-3)5-4-15(16)12-26-22/h4-5,8,10-11,13-14,22,26H,6-7,9,12H2,1-3H3,(H,27,28)(H,29,31)/t22-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50324590 ((R)-N-(2-(4-(Dimethylamino)-4-oxobutylthio)-4-(3-m...) Show SMILES COc1ccc2CN[C@H](Cc2c1)C(=O)Nc1ccc(cc1SCCC(=O)N(C)C)-c1cn[nH]c1 |r| Show InChI InChI=1S/C25H29N5O3S/c1-30(2)24(31)8-9-34-23-12-16(19-14-27-28-15-19)5-7-21(23)29-25(32)22-11-18-10-20(33-3)6-4-17(18)13-26-22/h4-7,10,12,14-15,22,26H,8-9,11,13H2,1-3H3,(H,27,28)(H,29,32)/t22-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50324599 ((R)-N-(4-(1H-Pyrazol-4-yl)-2-(2-(pyrrolidin-1-yl)e...) Show SMILES COc1ccc2CN[C@H](Cc2c1)C(=O)Nc1ccc(cc1OCCN1CCCC1)-c1cn[nH]c1 |r| Show InChI InChI=1S/C26H31N5O3/c1-33-22-6-4-19-15-27-24(13-20(19)12-22)26(32)30-23-7-5-18(21-16-28-29-17-21)14-25(23)34-11-10-31-8-2-3-9-31/h4-7,12,14,16-17,24,27H,2-3,8-11,13,15H2,1H3,(H,28,29)(H,30,32)/t24-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50324578 ((R)-N-(2-(2-(Dimethylamino)ethoxy)-5-fluoro-4-(1H-...) Show SMILES CN(C)CCOc1cc(-c2cn[nH]c2)c(F)cc1NC(=O)[C@H]1Cc2ccccc2CN1 |r| Show InChI InChI=1S/C23H26FN5O2/c1-29(2)7-8-31-22-10-18(17-13-26-27-14-17)19(24)11-20(22)28-23(30)21-9-15-5-3-4-6-16(15)12-25-21/h3-6,10-11,13-14,21,25H,7-9,12H2,1-2H3,(H,26,27)(H,28,30)/t21-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50324580 ((S)-N-(2-(2-(Dimethylamino)ethoxy)-4-(1H-pyrazol-4...) Show SMILES CN(C)CCOc1cc(ccc1NC(=O)[C@@H]1Cc2ccccc2CN1)-c1cn[nH]c1 |r| Show InChI InChI=1S/C23H27N5O2/c1-28(2)9-10-30-22-12-17(19-14-25-26-15-19)7-8-20(22)27-23(29)21-11-16-5-3-4-6-18(16)13-24-21/h3-8,12,14-15,21,24H,9-11,13H2,1-2H3,(H,25,26)(H,27,29)/t21-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50324573 ((R)-N-(2-(2-(Dimethylamino)ethoxy)-4-(1H-pyrazol-4...) Show SMILES CN(C)CCOc1cc(ccc1NC(=O)[C@H]1Cc2cc(Cl)ccc2CN1)-c1cn[nH]c1 |r| Show InChI InChI=1S/C23H26ClN5O2/c1-29(2)7-8-31-22-11-15(18-13-26-27-14-18)4-6-20(22)28-23(30)21-10-17-9-19(24)5-3-16(17)12-25-21/h3-6,9,11,13-14,21,25H,7-8,10,12H2,1-2H3,(H,26,27)(H,28,30)/t21-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50324581 ((R)-N-(2-(2-(Dimethylamino)ethoxy)-4-(1H-pyrazol-4...) Show SMILES CN(C)CCOc1cc(ccc1NC(=O)[C@H]1Cc2ccccc2CN1)-c1cn[nH]c1 |r| Show InChI InChI=1S/C23H27N5O2/c1-28(2)9-10-30-22-12-17(19-14-25-26-15-19)7-8-20(22)27-23(29)21-11-16-5-3-4-6-18(16)13-24-21/h3-8,12,14-15,21,24H,9-11,13H2,1-2H3,(H,25,26)(H,27,29)/t21-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50324579 ((R)-N-(2-(2-(dimethylamino)ethoxy)-4-(1H-pyrazol-4...) Show SMILES CCN1Cc2ccc(OC)cc2C[C@@H]1C(=O)Nc1cc(F)c(cc1OCCN(C)C)-c1cn[nH]c1 |r| Show InChI InChI=1S/C26H32FN5O3/c1-5-32-16-17-6-7-20(34-4)10-18(17)11-24(32)26(33)30-23-13-22(27)21(19-14-28-29-15-19)12-25(23)35-9-8-31(2)3/h6-7,10,12-15,24H,5,8-9,11,16H2,1-4H3,(H,28,29)(H,30,33)/t24-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM50324574 ((R)-6-Methoxy-N-(2-((1-methylpiperidin-4-yl)methox...) Show SMILES COc1ccc2CN[C@H](Cc2c1)C(=O)Nc1ccc(cc1OCC1CCN(C)CC1)-c1cn[nH]c1 |r| Show InChI InChI=1S/C27H33N5O3/c1-32-9-7-18(8-10-32)17-35-26-13-19(22-15-29-30-16-22)4-6-24(26)31-27(33)25-12-21-11-23(34-2)5-3-20(21)14-28-25/h3-6,11,13,15-16,18,25,28H,7-10,12,14,17H2,1-2H3,(H,29,30)(H,31,33)/t25-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK1				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50324577 ((S)-N-(2-(2-(Dimethylamino)ethoxy)-4-(1H-pyrazol-4...) Show SMILES COc1ccc2CN[C@@H](Cc2c1)C(=O)Nc1ccc(cc1OCCN(C)C)-c1cn[nH]c1 |r| Show InChI InChI=1S/C24H29N5O3/c1-29(2)8-9-32-23-12-16(19-14-26-27-15-19)5-7-21(23)28-24(30)22-11-18-10-20(31-3)6-4-17(18)13-25-22/h4-7,10,12,14-15,22,25H,8-9,11,13H2,1-3H3,(H,26,27)(H,28,30)/t22-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50324592 ((R)-N-(2-(2-(Dimethylamino)ethoxy)-5-fluoro-4-(1H-...) Show SMILES CCN1Cc2ccccc2C[C@@H]1C(=O)Nc1cc(F)c(cc1OCCN(C)C)-c1cn[nH]c1 |r| Show InChI InChI=1S/C25H30FN5O2/c1-4-31-16-18-8-6-5-7-17(18)11-23(31)25(32)29-22-13-21(26)20(19-14-27-28-15-19)12-24(22)33-10-9-30(2)3/h5-8,12-15,23H,4,9-11,16H2,1-3H3,(H,27,28)(H,29,32)/t23-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assay				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50324594 ((R)-N-(4-(1H-Pyrazol-4-yl)phenyl)-2-amino-3-(3-flu...) Show SMILES N[C@H](Cc1cccc(F)c1)C(=O)Nc1ccc(cc1)-c1cn[nH]c1 |r| Show InChI InChI=1S/C18H17FN4O/c19-15-3-1-2-12(8-15)9-17(20)18(24)23-16-6-4-13(5-7-16)14-10-21-22-11-14/h1-8,10-11,17H,9,20H2,(H,21,22)(H,23,24)/t17-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50324605 ((R)-N-(2-(2-(Dimethylamino)ethoxy)-5-fluoro-4-(1H-...) Show SMILES COc1ccc2CN[C@H](Cc2c1)C(=O)Nc1cc(F)c(cc1OCCN(C)C)-c1cn[nH]c1 |r| Show InChI InChI=1S/C24H28FN5O3/c1-30(2)6-7-33-23-10-19(17-13-27-28-14-17)20(25)11-21(23)29-24(31)22-9-16-8-18(32-3)5-4-15(16)12-26-22/h4-5,8,10-11,13-14,22,26H,6-7,9,12H2,1-3H3,(H,27,28)(H,29,31)/t22-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assay				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50324598 ((R)-N-(2-(2-(Dimethylamino)ethylthio)-4-(1H-pyrazo...) Show SMILES COc1ccc2CN[C@H](Cc2c1)C(=O)Nc1ccc(cc1SCCN(C)C)-c1cn[nH]c1 |r| Show InChI InChI=1S/C24H29N5O2S/c1-29(2)8-9-32-23-12-16(19-14-26-27-15-19)5-7-21(23)28-24(30)22-11-18-10-20(31-3)6-4-17(18)13-25-22/h4-7,10,12,14-15,22,25H,8-9,11,13H2,1-3H3,(H,26,27)(H,28,30)/t22-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50324578 ((R)-N-(2-(2-(Dimethylamino)ethoxy)-5-fluoro-4-(1H-...) Show SMILES CN(C)CCOc1cc(-c2cn[nH]c2)c(F)cc1NC(=O)[C@H]1Cc2ccccc2CN1 |r| Show InChI InChI=1S/C23H26FN5O2/c1-29(2)7-8-31-22-10-18(17-13-26-27-14-17)19(24)11-20(22)28-23(30)21-9-15-5-3-4-6-16(15)12-25-21/h3-6,10-11,13-14,21,25H,7-9,12H2,1-2H3,(H,26,27)(H,28,30)/t21-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assay				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM50324592 ((R)-N-(2-(2-(Dimethylamino)ethoxy)-5-fluoro-4-(1H-...) Show SMILES CCN1Cc2ccccc2C[C@@H]1C(=O)Nc1cc(F)c(cc1OCCN(C)C)-c1cn[nH]c1 |r| Show InChI InChI=1S/C25H30FN5O2/c1-4-31-16-18-8-6-5-7-17(18)11-23(31)25(32)29-22-13-21(26)20(19-14-27-28-15-19)12-24(22)33-10-9-30(2)3/h5-8,12-15,23H,4,9-11,16H2,1-3H3,(H,27,28)(H,29,32)/t23-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK1				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50324601 ((R)-N-(2-(2-(Dimethylamino)ethylthio)-4-(3-methyl-...) Show SMILES COc1ccc2CN[C@H](Cc2c1)C(=O)Nc1ccc(cc1SCCN(C)C)-c1cn[nH]c1C |r| Show InChI InChI=1S/C25H31N5O2S/c1-16-21(15-27-29-16)17-6-8-22(24(13-17)33-10-9-30(2)3)28-25(31)23-12-19-11-20(32-4)7-5-18(19)14-26-23/h5-8,11,13,15,23,26H,9-10,12,14H2,1-4H3,(H,27,29)(H,28,31)/t23-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50324603 ((R)-N-(2-(2-(Dimethylamino)ethoxy)-5-fluoro-4-(1H-...) Show SMILES CN(C)CCOc1cc(-c2cn[nH]c2)c(F)cc1NC(=O)[C@H]1Cc2ccccc2CN1C |r| Show InChI InChI=1S/C24H28FN5O2/c1-29(2)8-9-32-23-11-19(18-13-26-27-14-18)20(25)12-21(23)28-24(31)22-10-16-6-4-5-7-17(16)15-30(22)3/h4-7,11-14,22H,8-10,15H2,1-3H3,(H,26,27)(H,28,31)/t22-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50324582 ((R)-2-(Cyclopropylmethyl)-N-(2-(2-(dimethylamino)e...) Show SMILES CN(C)CCOc1cc(-c2cn[nH]c2)c(F)cc1NC(=O)[C@H]1Cc2ccccc2CN1CC1CC1 |r| Show InChI InChI=1S/C27H32FN5O2/c1-32(2)9-10-35-26-12-22(21-14-29-30-15-21)23(28)13-24(26)31-27(34)25-11-19-5-3-4-6-20(19)17-33(25)16-18-7-8-18/h3-6,12-15,18,25H,7-11,16-17H2,1-2H3,(H,29,30)(H,31,34)/t25-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assay				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50324604 (CHEMBL1215021 | N-(4-(1H-Pyrazol-4-yl)phenyl)-2-am...) Show SMILES NC(Cc1ccc(Cl)cc1)C(=O)Nc1ccc(cc1)-c1cn[nH]c1 Show InChI InChI=1S/C18H17ClN4O/c19-15-5-1-12(2-6-15)9-17(20)18(24)23-16-7-3-13(4-8-16)14-10-21-22-11-14/h1-8,10-11,17H,9,20H2,(H,21,22)(H,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assay				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50324588 (2-Amino-2-(4-chlorophenyl)-N-(2-(2-(dimethylamino)...) Show SMILES CN(C)CCOc1cc(ccc1NC(=O)C(N)c1ccc(Cl)cc1)-c1cn[nH]c1 Show InChI InChI=1S/C21H24ClN5O2/c1-27(2)9-10-29-19-11-15(16-12-24-25-13-16)5-8-18(19)26-21(28)20(23)14-3-6-17(22)7-4-14/h3-8,11-13,20H,9-10,23H2,1-2H3,(H,24,25)(H,26,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50324586 ((R)-N-(2-(2-(Dimethylamino)ethoxy)-6-fluoro-4-(1H-...) Show SMILES COc1ccc2CN[C@H](Cc2c1)C(=O)Nc1c(F)cc(cc1OCCN(C)C)-c1cn[nH]c1 |r| Show InChI InChI=1S/C24H28FN5O3/c1-30(2)6-7-33-22-11-17(18-13-27-28-14-18)9-20(25)23(22)29-24(31)21-10-16-8-19(32-3)5-4-15(16)12-26-21/h4-5,8-9,11,13-14,21,26H,6-7,10,12H2,1-3H3,(H,27,28)(H,29,31)/t21-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50324587 ((S)-N-(2-(2-(Dimethylamino)ethoxy)-4-(1H-pyrazol-4...) Show SMILES CN(C)CCOc1cc(ccc1NC(=O)[C@@H]1Cc2cc(Cl)ccc2CN1)-c1cn[nH]c1 |r| Show InChI InChI=1S/C23H26ClN5O2/c1-29(2)7-8-31-22-11-15(18-13-26-27-14-18)4-6-20(22)28-23(30)21-10-17-9-19(24)5-3-16(17)12-25-21/h3-6,9,11,13-14,21,25H,7-8,10,12H2,1-2H3,(H,26,27)(H,28,30)/t21-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50324585 (CHEMBL1215022 | N-(4-(1H-Pyrazol-4-yl)phenyl)-2-am...) Show SMILES NC(C(=O)Nc1ccc(cc1)-c1cn[nH]c1)c1ccc(Cl)cc1 Show InChI InChI=1S/C17H15ClN4O/c18-14-5-1-12(2-6-14)16(19)17(23)22-15-7-3-11(4-8-15)13-9-20-21-10-13/h1-10,16H,19H2,(H,20,21)(H,22,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assay				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50324584 ((R)-6-Methoxy-N-(2-(2-methoxyethoxy)-4-(1H-pyrazol...) Show SMILES COCCOc1cc(ccc1NC(=O)[C@H]1Cc2cc(OC)ccc2CN1)-c1cn[nH]c1 |r| Show InChI InChI=1S/C23H26N4O4/c1-29-7-8-31-22-11-15(18-13-25-26-14-18)4-6-20(22)27-23(28)21-10-17-9-19(30-2)5-3-16(17)12-24-21/h3-6,9,11,13-14,21,24H,7-8,10,12H2,1-2H3,(H,25,26)(H,27,28)/t21-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50324583 ((R)-N-(2-(2-(Dimethylamino)ethoxy)-3-fluoro-4-(1H-...) Show SMILES COc1ccc2CN[C@H](Cc2c1)C(=O)Nc1ccc(-c2cn[nH]c2)c(F)c1OCCN(C)C |r| Show InChI InChI=1S/C24H28FN5O3/c1-30(2)8-9-33-23-20(7-6-19(22(23)25)17-13-27-28-14-17)29-24(31)21-11-16-10-18(32-3)5-4-15(16)12-26-21/h4-7,10,13-14,21,26H,8-9,11-12H2,1-3H3,(H,27,28)(H,29,31)/t21-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50324582 ((R)-2-(Cyclopropylmethyl)-N-(2-(2-(dimethylamino)e...) Show SMILES CN(C)CCOc1cc(-c2cn[nH]c2)c(F)cc1NC(=O)[C@H]1Cc2ccccc2CN1CC1CC1 |r| Show InChI InChI=1S/C27H32FN5O2/c1-32(2)9-10-35-26-12-22(21-14-29-30-15-21)23(28)13-24(26)31-27(34)25-11-19-5-3-4-6-20(19)17-33(25)16-18-7-8-18/h3-6,12-15,18,25H,7-11,16-17H2,1-2H3,(H,29,30)(H,31,34)/t25-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50324580 ((S)-N-(2-(2-(Dimethylamino)ethoxy)-4-(1H-pyrazol-4...) Show SMILES CN(C)CCOc1cc(ccc1NC(=O)[C@@H]1Cc2ccccc2CN1)-c1cn[nH]c1 |r| Show InChI InChI=1S/C23H27N5O2/c1-28(2)9-10-30-22-12-17(19-14-25-26-15-19)7-8-20(22)27-23(29)21-11-16-5-3-4-6-18(16)13-24-21/h3-8,12,14-15,21,24H,9-11,13H2,1-2H3,(H,25,26)(H,27,29)/t21-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assay				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50324579 ((R)-N-(2-(2-(dimethylamino)ethoxy)-4-(1H-pyrazol-4...) Show SMILES CCN1Cc2ccc(OC)cc2C[C@@H]1C(=O)Nc1cc(F)c(cc1OCCN(C)C)-c1cn[nH]c1 |r| Show InChI InChI=1S/C26H32FN5O3/c1-5-32-16-17-6-7-20(34-4)10-18(17)11-24(32)26(33)30-23-13-22(27)21(19-14-28-29-15-19)12-25(23)35-9-8-31(2)3/h6-7,10,12-15,24H,5,8-9,11,16H2,1-4H3,(H,28,29)(H,30,33)/t24-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assay				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50324581 ((R)-N-(2-(2-(Dimethylamino)ethoxy)-4-(1H-pyrazol-4...) Show SMILES CN(C)CCOc1cc(ccc1NC(=O)[C@H]1Cc2ccccc2CN1)-c1cn[nH]c1 |r| Show InChI InChI=1S/C23H27N5O2/c1-28(2)9-10-30-22-12-17(19-14-25-26-15-19)7-8-20(22)27-23(29)21-11-16-5-3-4-6-18(16)13-24-21/h3-8,12,14-15,21,24H,9-11,13H2,1-2H3,(H,25,26)(H,27,29)/t21-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assay				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM50324578 ((R)-N-(2-(2-(Dimethylamino)ethoxy)-5-fluoro-4-(1H-...) Show SMILES CN(C)CCOc1cc(-c2cn[nH]c2)c(F)cc1NC(=O)[C@H]1Cc2ccccc2CN1 |r| Show InChI InChI=1S/C23H26FN5O2/c1-29(2)7-8-31-22-10-18(17-13-26-27-14-17)19(24)11-20(22)28-23(30)21-9-15-5-3-4-6-16(15)12-25-21/h3-6,10-11,13-14,21,25H,7-9,12H2,1-2H3,(H,26,27)(H,28,30)/t21-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK1				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50324577 ((S)-N-(2-(2-(Dimethylamino)ethoxy)-4-(1H-pyrazol-4...) Show SMILES COc1ccc2CN[C@@H](Cc2c1)C(=O)Nc1ccc(cc1OCCN(C)C)-c1cn[nH]c1 |r| Show InChI InChI=1S/C24H29N5O3/c1-29(2)8-9-32-23-12-16(19-14-26-27-15-19)5-7-21(23)28-24(30)22-11-18-10-20(31-3)6-4-17(18)13-25-22/h4-7,10,12,14-15,22,25H,8-9,11,13H2,1-3H3,(H,26,27)(H,28,30)/t22-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assay				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50324576 ((R)-N-(2-(2-Hydroxyethoxy)-4-(1H-pyrazol-4-yl)phen...) Show SMILES COc1ccc2CN[C@H](Cc2c1)C(=O)Nc1ccc(cc1OCCO)-c1cn[nH]c1 |r| Show InChI InChI=1S/C22H24N4O4/c1-29-18-4-2-15-11-23-20(9-16(15)8-18)22(28)26-19-5-3-14(17-12-24-25-13-17)10-21(19)30-7-6-27/h2-5,8,10,12-13,20,23,27H,6-7,9,11H2,1H3,(H,24,25)(H,26,28)/t20-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM50324575 ((R)-N-(2-(2-(Dimethylamino)ethoxy)-4-(1H-pyrazol-4...) Show SMILES COc1ccc2CN[C@H](Cc2c1)C(=O)Nc1ccc(cc1OCCN(C)C)-c1cn[nH]c1 |r| Show InChI InChI=1S/C24H29N5O3/c1-29(2)8-9-32-23-12-16(19-14-26-27-15-19)5-7-21(23)28-24(30)22-11-18-10-20(31-3)6-4-17(18)13-25-22/h4-7,10,12,14-15,22,25H,8-9,11,13H2,1-3H3,(H,26,27)(H,28,30)/t22-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	48	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK1				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50324574 ((R)-6-Methoxy-N-(2-((1-methylpiperidin-4-yl)methox...) Show SMILES COc1ccc2CN[C@H](Cc2c1)C(=O)Nc1ccc(cc1OCC1CCN(C)CC1)-c1cn[nH]c1 |r| Show InChI InChI=1S/C27H33N5O3/c1-32-9-7-18(8-10-32)17-35-26-13-19(22-15-29-30-16-22)4-6-24(26)31-27(33)25-12-21-11-23(34-2)5-3-20(21)14-28-25/h3-6,11,13,15-16,18,25,28H,7-10,12,14,17H2,1-2H3,(H,29,30)(H,31,33)/t25-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	51	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assay				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50324575 ((R)-N-(2-(2-(Dimethylamino)ethoxy)-4-(1H-pyrazol-4...) Show SMILES COc1ccc2CN[C@H](Cc2c1)C(=O)Nc1ccc(cc1OCCN(C)C)-c1cn[nH]c1 |r| Show InChI InChI=1S/C24H29N5O3/c1-29(2)8-9-32-23-12-16(19-14-26-27-15-19)5-7-21(23)28-24(30)22-11-18-10-20(31-3)6-4-17(18)13-25-22/h4-7,10,12,14-15,22,25H,8-9,11,13H2,1-3H3,(H,26,27)(H,28,30)/t22-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	51	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50324573 ((R)-N-(2-(2-(Dimethylamino)ethoxy)-4-(1H-pyrazol-4...) Show SMILES CN(C)CCOc1cc(ccc1NC(=O)[C@H]1Cc2cc(Cl)ccc2CN1)-c1cn[nH]c1 |r| Show InChI InChI=1S/C23H26ClN5O2/c1-29(2)7-8-31-22-11-15(18-13-26-27-14-18)4-6-20(22)28-23(30)21-10-17-9-19(24)5-3-16(17)12-25-21/h3-6,9,11,13-14,21,25H,7-8,10,12H2,1-2H3,(H,26,27)(H,28,30)/t21-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	52	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assay				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50324572 ((R)-N-(2-(2-(Dimethylamino)ethoxy)-4-(1H-pyrazol-4...) Show SMILES CN(C)CCOc1cc(ccc1NC(=O)[C@H]1Cc2cc(F)ccc2CN1)-c1cn[nH]c1 |r| Show InChI InChI=1S/C23H26FN5O2/c1-29(2)7-8-31-22-11-15(18-13-26-27-14-18)4-6-20(22)28-23(30)21-10-17-9-19(24)5-3-16(17)12-25-21/h3-6,9,11,13-14,21,25H,7-8,10,12H2,1-2H3,(H,26,27)(H,28,30)/t21-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	59	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50324603 ((R)-N-(2-(2-(Dimethylamino)ethoxy)-5-fluoro-4-(1H-...) Show SMILES CN(C)CCOc1cc(-c2cn[nH]c2)c(F)cc1NC(=O)[C@H]1Cc2ccccc2CN1C |r| Show InChI InChI=1S/C24H28FN5O2/c1-29(2)8-9-32-23-11-19(18-13-26-27-14-18)20(25)12-21(23)28-24(31)22-10-16-6-4-5-7-17(16)15-30(22)3/h4-7,11-14,22H,8-10,15H2,1-3H3,(H,26,27)(H,28,31)/t22-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	62	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assay				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50324602 ((R)-6-Methoxy-N-(2-(1-methylpiperidin-4-yloxy)-4-(...) Show SMILES COc1ccc2CN[C@H](Cc2c1)C(=O)Nc1ccc(cc1OC1CCN(C)CC1)-c1cn[nH]c1 |r| Show InChI InChI=1S/C26H31N5O3/c1-31-9-7-21(8-10-31)34-25-13-17(20-15-28-29-16-20)4-6-23(25)30-26(32)24-12-19-11-22(33-2)5-3-18(19)14-27-24/h3-6,11,13,15-16,21,24,27H,7-10,12,14H2,1-2H3,(H,28,29)(H,30,32)/t24-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assay				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50324601 ((R)-N-(2-(2-(Dimethylamino)ethylthio)-4-(3-methyl-...) Show SMILES COc1ccc2CN[C@H](Cc2c1)C(=O)Nc1ccc(cc1SCCN(C)C)-c1cn[nH]c1C |r| Show InChI InChI=1S/C25H31N5O2S/c1-16-21(15-27-29-16)17-6-8-22(24(13-17)33-10-9-30(2)3)28-25(31)23-12-19-11-20(32-4)7-5-18(19)14-26-23/h5-8,11,13,15,23,26H,9-10,12,14H2,1-4H3,(H,27,29)(H,28,31)/t23-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	74	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assay				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50324587 ((S)-N-(2-(2-(Dimethylamino)ethoxy)-4-(1H-pyrazol-4...) Show SMILES CN(C)CCOc1cc(ccc1NC(=O)[C@@H]1Cc2cc(Cl)ccc2CN1)-c1cn[nH]c1 |r| Show InChI InChI=1S/C23H26ClN5O2/c1-29(2)7-8-31-22-11-15(18-13-26-27-14-18)4-6-20(22)28-23(30)21-10-17-9-19(24)5-3-16(17)12-25-21/h3-6,9,11,13-14,21,25H,7-8,10,12H2,1-2H3,(H,26,27)(H,28,30)/t21-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	85	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assay				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50324600 (CHEMBL1215238 | rac-N-(2-(2-(Dimethylamino)ethoxy)...) Show SMILES CCOc1ccc2CNC(Cc2c1)C(=O)Nc1ccc(cc1OCCN(C)C)-c1cn[nH]c1 Show InChI InChI=1S/C25H31N5O3/c1-4-32-21-7-5-18-14-26-23(12-19(18)11-21)25(31)29-22-8-6-17(20-15-27-28-16-20)13-24(22)33-10-9-30(2)3/h5-8,11,13,15-16,23,26H,4,9-10,12,14H2,1-3H3,(H,27,28)(H,29,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	156	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50324586 ((R)-N-(2-(2-(Dimethylamino)ethoxy)-6-fluoro-4-(1H-...) Show SMILES COc1ccc2CN[C@H](Cc2c1)C(=O)Nc1c(F)cc(cc1OCCN(C)C)-c1cn[nH]c1 |r| Show InChI InChI=1S/C24H28FN5O3/c1-30(2)6-7-33-22-11-17(18-13-27-28-14-18)9-20(25)23(22)29-24(31)21-10-16-8-19(32-3)5-4-15(16)12-26-21/h4-5,8-9,11,13-14,21,26H,6-7,10,12H2,1-3H3,(H,27,28)(H,29,31)/t21-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assay				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50324599 ((R)-N-(4-(1H-Pyrazol-4-yl)-2-(2-(pyrrolidin-1-yl)e...) Show SMILES COc1ccc2CN[C@H](Cc2c1)C(=O)Nc1ccc(cc1OCCN1CCCC1)-c1cn[nH]c1 |r| Show InChI InChI=1S/C26H31N5O3/c1-33-22-6-4-19-15-27-24(13-20(19)12-22)26(32)30-23-7-5-18(21-16-28-29-17-21)14-25(23)34-11-10-31-8-2-3-9-31/h4-7,12,14,16-17,24,27H,2-3,8-11,13,15H2,1H3,(H,28,29)(H,30,32)/t24-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	218	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assay				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair

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