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Patent code US8575157

Compile Data Set for Download or QSAR

Found 341 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM107578
PNG
(US8575157, 2)
Show SMILES C[C@H](N1CC[C@@](CC(C)(C)O)(OC1=O)c1ccccc1)c1ccc(cc1)-c1cc[nH]c(=O)c1 |r|
Show InChI InChI=1S/C27H30N2O4/c1-19(20-9-11-21(12-10-20)22-13-15-28-24(30)17-22)29-16-14-27(33-25(29)31,18-26(2,3)32)23-7-5-4-6-8-23/h4-13,15,17,19,32H,14,16,18H2,1-3H3,(H,28,30)/t19-,27-/m0/s1
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n/an/a 0.310n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH

US Patent


Assay Description
The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...

US Patent US8575157 (2013)


BindingDB Entry DOI: 10.7270/Q2416VPS
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM50353390
PNG
(CHEMBL1829768 | US8575157, 193 | US8592410, Compar...)
Show SMILES C[C@H](N1CC[C@@](CCO)(OC1=O)c1ccc(F)cc1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C26H25F2NO3/c1-18(19-2-4-20(5-3-19)21-6-10-23(27)11-7-21)29-16-14-26(15-17-30,32-25(29)31)22-8-12-24(28)13-9-22/h2-13,18,30H,14-17H2,1H3/t18-,26-/m0/s1
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n/an/a 0.510n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH

US Patent


Assay Description
The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...

US Patent US8575157 (2013)


BindingDB Entry DOI: 10.7270/Q2416VPS
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM107485
PNG
(US8575157, 199 | US8592410, Comparator 11 | US8598...)
Show SMILES C[C@H](N1CC[C@@](CCC(N)=O)(OC1=O)c1ccccc1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C27H27FN2O3/c1-19(20-7-9-21(10-8-20)22-11-13-24(28)14-12-22)30-18-17-27(33-26(30)32,16-15-25(29)31)23-5-3-2-4-6-23/h2-14,19H,15-18H2,1H3,(H2,29,31)/t19-,27+/m0/s1
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n/an/a 0.550n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH

US Patent


Assay Description
The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...

US Patent US8575157 (2013)


BindingDB Entry DOI: 10.7270/Q2416VPS
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM50353392
PNG
(CHEMBL1829761 | US8575157, 197 | US8592410, Compar...)
Show SMILES C[C@H](N1CC[C@@](CCCO)(OC1=O)c1ccccc1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C27H28FNO3/c1-20(21-8-10-22(11-9-21)23-12-14-25(28)15-13-23)29-18-17-27(16-5-19-30,32-26(29)31)24-6-3-2-4-7-24/h2-4,6-15,20,30H,5,16-19H2,1H3/t20-,27+/m0/s1
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n/an/a 0.550n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH

US Patent


Assay Description
The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...

US Patent US8575157 (2013)


BindingDB Entry DOI: 10.7270/Q2416VPS
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM107586
PNG
(US8575157, 15)
Show SMILES C[C@H](N1CC[C@@](CC(C)(C)C#N)(OC1=O)c1ccc(F)cc1)c1ccc(cc1)-c1ccc(=O)[nH]c1 |r|
Show InChI InChI=1S/C28H28FN3O3/c1-19(20-4-6-21(7-5-20)22-8-13-25(33)31-16-22)32-15-14-28(35-26(32)34,17-27(2,3)18-30)23-9-11-24(29)12-10-23/h4-13,16,19H,14-15,17H2,1-3H3,(H,31,33)/t19-,28-/m0/s1
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n/an/a 0.580n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH

US Patent


Assay Description
The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...

US Patent US8575157 (2013)


BindingDB Entry DOI: 10.7270/Q2416VPS
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM107601
PNG
(US8575157, 50)
Show SMILES C[C@H](N1CC[C@@](CC(C)(C)C#N)(OC1=O)c1ccccc1)c1ccc(cc1)-c1ccn(C)c(=O)c1 |r|
Show InChI InChI=1S/C29H31N3O3/c1-21(22-10-12-23(13-11-22)24-14-16-31(4)26(33)18-24)32-17-15-29(35-27(32)34,19-28(2,3)20-30)25-8-6-5-7-9-25/h5-14,16,18,21H,15,17,19H2,1-4H3/t21-,29-/m0/s1
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n/an/a 0.610n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH

US Patent


Assay Description
The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...

US Patent US8575157 (2013)


BindingDB Entry DOI: 10.7270/Q2416VPS
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM107666
PNG
(US8575157, 230)
Show SMILES C[C@H](N1CC[C@@](CC(C)(C)C#C)(OC1=O)c1ccccc1)c1ccc(cc1)-c1ccc(=O)[nH]c1 |r|
Show InChI InChI=1S/C29H30N2O3/c1-5-28(3,4)20-29(25-9-7-6-8-10-25)17-18-31(27(33)34-29)21(2)22-11-13-23(14-12-22)24-15-16-26(32)30-19-24/h1,6-16,19,21H,17-18,20H2,2-4H3,(H,30,32)/t21-,29-/m0/s1
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n/an/a 0.650n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH

US Patent


Assay Description
The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...

US Patent US8575157 (2013)


BindingDB Entry DOI: 10.7270/Q2416VPS
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM107619
PNG
(US8575157, 69)
Show SMILES C[C@H](N1CC[C@@](CC(C)(C)C#N)(OC1=O)c1ccc(F)cc1)c1ccc(cc1)-c1ccc(=O)n(C)c1 |r|
Show InChI InChI=1S/C29H30FN3O3/c1-20(21-5-7-22(8-6-21)23-9-14-26(34)32(4)17-23)33-16-15-29(36-27(33)35,18-28(2,3)19-31)24-10-12-25(30)13-11-24/h5-14,17,20H,15-16,18H2,1-4H3/t20-,29-/m0/s1
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n/an/a 0.720n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH

US Patent


Assay Description
The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...

US Patent US8575157 (2013)


BindingDB Entry DOI: 10.7270/Q2416VPS
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM50353405
PNG
(CHEMBL1829759 | US8575157, 196 | US8592410, 93 | U...)
Show SMILES C[C@H](N1CC[C@@](CCCO)(OC1=O)c1ccccc1)c1ccc(cc1)-c1ccc(F)cc1F |r|
Show InChI InChI=1S/C27H27F2NO3/c1-19(20-8-10-21(11-9-20)24-13-12-23(28)18-25(24)29)30-16-15-27(14-5-17-31,33-26(30)32)22-6-3-2-4-7-22/h2-4,6-13,18-19,31H,5,14-17H2,1H3/t19-,27+/m0/s1
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n/an/a 0.720n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH

US Patent


Assay Description
The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...

US Patent US8575157 (2013)


BindingDB Entry DOI: 10.7270/Q2416VPS
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM107610
PNG
(US8575157, 60)
Show SMILES CC[C@H](N1CC[C@@](CC)(OC1=O)c1ccccc1)c1ccc(cc1)-c1ccc(=O)n(c1)C(C)C |r|
Show InChI InChI=1S/C29H34N2O3/c1-5-26(30-19-18-29(6-2,34-28(30)33)25-10-8-7-9-11-25)23-14-12-22(13-15-23)24-16-17-27(32)31(20-24)21(3)4/h7-17,20-21,26H,5-6,18-19H2,1-4H3/t26-,29+/m0/s1
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n/an/a 0.75n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH

US Patent


Assay Description
The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...

US Patent US8575157 (2013)


BindingDB Entry DOI: 10.7270/Q2416VPS
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM50353386
PNG
(CHEMBL1829763 | US8592410, 88 | US8592410, Compara...)
Show SMILES C[C@H](N1CC[C@@](CCO)(OC1=O)c1ccc(F)cc1)c1ccc(cc1)-c1ccc(F)cc1F |r|
Show InChI InChI=1S/C26H24F3NO3/c1-17(18-2-4-19(5-3-18)23-11-10-22(28)16-24(23)29)30-14-12-26(13-15-31,33-25(30)32)20-6-8-21(27)9-7-20/h2-11,16-17,31H,12-15H2,1H3/t17-,26-/m0/s1
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n/an/a 0.75n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH

US Patent


Assay Description
The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...

US Patent US8575157 (2013)


BindingDB Entry DOI: 10.7270/Q2416VPS
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM107487
PNG
(US8575157, 201 | US8592410, Comparator 13 | US8598...)
Show SMILES C[C@H](N1CC[C@@](CC(C)(C)O)(OC1=O)c1ccc(F)cc1)c1ccc(Br)cc1 |r|
Show InChI InChI=1S/C22H25BrFNO3/c1-15(16-4-8-18(23)9-5-16)25-13-12-22(28-20(25)26,14-21(2,3)27)17-6-10-19(24)11-7-17/h4-11,15,27H,12-14H2,1-3H3/t15-,22-/m0/s1
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n/an/a 0.760n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH

US Patent


Assay Description
The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...

US Patent US8575157 (2013)


BindingDB Entry DOI: 10.7270/Q2416VPS
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM107481
PNG
(US8575157, 189 | US8592410, Comparator 1 | US85981...)
Show SMILES OCC[C@@]1(CCN(C(=O)O1)c1cccc(c1)-c1ccc(F)cc1F)c1ccccc1 |r|
Show InChI InChI=1S/C24H21F2NO3/c25-19-9-10-21(22(26)16-19)17-5-4-8-20(15-17)27-13-11-24(12-14-28,30-23(27)29)18-6-2-1-3-7-18/h1-10,15-16,28H,11-14H2/t24-/m0/s1
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n/an/a 0.770n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH

US Patent


Assay Description
The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...

US Patent US8575157 (2013)


BindingDB Entry DOI: 10.7270/Q2416VPS
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM107489
PNG
(US8575157, 203 | US8592410, Comparator 15 | US8598...)
Show SMILES C[C@H](N1CC[C@@](CC(C)(C)O)(OC1=O)c1ccccc1)c1ccc(Br)cc1 |r|
Show InChI InChI=1S/C22H26BrNO3/c1-16(17-9-11-19(23)12-10-17)24-14-13-22(27-20(24)25,15-21(2,3)26)18-7-5-4-6-8-18/h4-12,16,26H,13-15H2,1-3H3/t16-,22-/m0/s1
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n/an/a 0.790n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH

US Patent


Assay Description
The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...

US Patent US8575157 (2013)


BindingDB Entry DOI: 10.7270/Q2416VPS
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM107615
PNG
(US8575157, 65)
Show SMILES CCn1ccc(cc1=O)-c1ccc(cc1)[C@H](C)N1CC[C@@](CC(C)(C)O)(OC1=O)c1ccccc1 |r|
Show InChI InChI=1S/C29H34N2O4/c1-5-30-17-15-24(19-26(30)32)23-13-11-22(12-14-23)21(2)31-18-16-29(35-27(31)33,20-28(3,4)34)25-9-7-6-8-10-25/h6-15,17,19,21,34H,5,16,18,20H2,1-4H3/t21-,29-/m0/s1
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n/an/a 0.800n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH

US Patent


Assay Description
The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...

US Patent US8575157 (2013)


BindingDB Entry DOI: 10.7270/Q2416VPS
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM107609
PNG
(US8575157, 58)
Show SMILES CC[C@H](N1CC[C@@](CC)(OC1=O)c1ccccc1)c1ccc(cc1)-c1ccn(C)c(=O)c1 |r|
Show InChI InChI=1S/C27H30N2O3/c1-4-24(21-13-11-20(12-14-21)22-15-17-28(3)25(30)19-22)29-18-16-27(5-2,32-26(29)31)23-9-7-6-8-10-23/h6-15,17,19,24H,4-5,16,18H2,1-3H3/t24-,27+/m0/s1
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n/an/a 0.870n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH

US Patent


Assay Description
The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...

US Patent US8575157 (2013)


BindingDB Entry DOI: 10.7270/Q2416VPS
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM107645
PNG
(US8575157, 16)
Show SMILES C[C@H](N1CC[C@@](CC(C)(C)C#N)(OC1=O)c1ccc(F)cc1)c1ccc(cc1)-c1ccn(C)c(=O)c1 |r|
Show InChI InChI=1S/C29H30FN3O3/c1-20(21-5-7-22(8-6-21)23-13-15-32(4)26(34)17-23)33-16-14-29(36-27(33)35,18-28(2,3)19-31)24-9-11-25(30)12-10-24/h5-13,15,17,20H,14,16,18H2,1-4H3/t20-,29-/m0/s1
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n/an/a 0.900n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH

US Patent


Assay Description
The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...

US Patent US8575157 (2013)


BindingDB Entry DOI: 10.7270/Q2416VPS
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM107663
PNG
(US8575157, 47)
Show SMILES C[C@H](N1CC[C@@](CCCO)(OC1=O)c1ccccc1)c1ccc(cc1)-c1ccn(C)c(=O)c1 |r|
Show InChI InChI=1S/C27H30N2O4/c1-20(21-9-11-22(12-10-21)23-13-16-28(2)25(31)19-23)29-17-15-27(14-6-18-30,33-26(29)32)24-7-4-3-5-8-24/h3-5,7-13,16,19-20,30H,6,14-15,17-18H2,1-2H3/t20-,27+/m0/s1
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n/an/a 0.960n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH

US Patent


Assay Description
The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...

US Patent US8575157 (2013)


BindingDB Entry DOI: 10.7270/Q2416VPS
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM107618
PNG
(US8575157, 68)
Show SMILES CC(C)n1ccc(cc1=O)-c1ccc(cc1)[C@H](C)N1CC[C@@](CC(C)(C)O)(OC1=O)c1ccccc1 |r|
Show InChI InChI=1S/C30H36N2O4/c1-21(2)31-17-15-25(19-27(31)33)24-13-11-23(12-14-24)22(3)32-18-16-30(36-28(32)34,20-29(4,5)35)26-9-7-6-8-10-26/h6-15,17,19,21-22,35H,16,18,20H2,1-5H3/t22-,30-/m0/s1
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n/an/a 0.960n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH

US Patent


Assay Description
The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...

US Patent US8575157 (2013)


BindingDB Entry DOI: 10.7270/Q2416VPS
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM50353387
PNG
(CHEMBL1829777 | US8575157, 195 | US8592410, Compar...)
Show SMILES C[C@H](N1CC[C@@](CCC(N)=O)(OC1=O)c1ccc(F)cc1)c1ccc(cc1)-c1ccc(F)cc1F |r|
Show InChI InChI=1S/C27H25F3N2O3/c1-17(18-2-4-19(5-3-18)23-11-10-22(29)16-24(23)30)32-15-14-27(35-26(32)34,13-12-25(31)33)20-6-8-21(28)9-7-20/h2-11,16-17H,12-15H2,1H3,(H2,31,33)/t17-,27+/m0/s1
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n/an/a 0.990n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH

US Patent


Assay Description
The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...

US Patent US8575157 (2013)


BindingDB Entry DOI: 10.7270/Q2416VPS
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM107620
PNG
(US8575157, 70)
Show SMILES CCn1cc(cc(C)c1=O)-c1ccc(cc1)[C@H](C)N1CC[C@@](CC(C)(C)O)(OC1=O)c1ccccc1 |r|
Show InChI InChI=1S/C30H36N2O4/c1-6-31-19-25(18-21(2)27(31)33)24-14-12-23(13-15-24)22(3)32-17-16-30(36-28(32)34,20-29(4,5)35)26-10-8-7-9-11-26/h7-15,18-19,22,35H,6,16-17,20H2,1-5H3/t22-,30-/m0/s1
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n/an/a 1.01n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH

US Patent


Assay Description
The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...

US Patent US8575157 (2013)


BindingDB Entry DOI: 10.7270/Q2416VPS
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM107600
PNG
(US8575157, 49)
Show SMILES C[C@H](N1CC[C@@](CC(C)(C)C#N)(OC1=O)c1ccccc1)c1ccc(cc1)-c1ccc(=O)n(C)c1 |r|
Show InChI InChI=1S/C29H31N3O3/c1-21(22-10-12-23(13-11-22)24-14-15-26(33)31(4)18-24)32-17-16-29(35-27(32)34,19-28(2,3)20-30)25-8-6-5-7-9-25/h5-15,18,21H,16-17,19H2,1-4H3/t21-,29-/m0/s1
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n/an/a 1.03n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH

US Patent


Assay Description
The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...

US Patent US8575157 (2013)


BindingDB Entry DOI: 10.7270/Q2416VPS
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM107607
PNG
(US8575157, 56)
Show SMILES CC[C@H](N1CC[C@@](CC)(OC1=O)c1ccccc1)c1ccc(cc1)-c1ccc(=O)n(C)c1 |r|
Show InChI InChI=1S/C27H30N2O3/c1-4-24(21-13-11-20(12-14-21)22-15-16-25(30)28(3)19-22)29-18-17-27(5-2,32-26(29)31)23-9-7-6-8-10-23/h6-16,19,24H,4-5,17-18H2,1-3H3/t24-,27+/m0/s1
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n/an/a 1.03n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH

US Patent


Assay Description
The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...

US Patent US8575157 (2013)


BindingDB Entry DOI: 10.7270/Q2416VPS
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM107597
PNG
(US8575157, 44)
Show SMILES CC[C@H](N1CC[C@@](CCCO)(OC1=O)c1ccccc1)c1ccc(cc1)-c1ccc(=O)n(C)c1 |r|
Show InChI InChI=1S/C28H32N2O4/c1-3-25(22-12-10-21(11-13-22)23-14-15-26(32)29(2)20-23)30-18-17-28(16-7-19-31,34-27(30)33)24-8-5-4-6-9-24/h4-6,8-15,20,25,31H,3,7,16-19H2,1-2H3/t25-,28+/m0/s1
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n/an/a 1.08n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH

US Patent


Assay Description
The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...

US Patent US8575157 (2013)


BindingDB Entry DOI: 10.7270/Q2416VPS
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM107486
PNG
(US8575157, 200 | US8592410, Comparator 12 | US8598...)
Show SMILES C[C@H](N1CC[C@@](CC(C)(C)O)(OC1=O)c1ccccc1)c1ccc(cc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C28H30FNO3/c1-20(21-9-11-22(12-10-21)23-13-15-25(29)16-14-23)30-18-17-28(33-26(30)31,19-27(2,3)32)24-7-5-4-6-8-24/h4-16,20,32H,17-19H2,1-3H3/t20-,28-/m0/s1
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n/an/a 1.08n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH

US Patent


Assay Description
The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...

US Patent US8575157 (2013)


BindingDB Entry DOI: 10.7270/Q2416VPS
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM107585
PNG
(US8575157, 14)
Show SMILES C[C@H](N1CC[C@@](CC(C)(C)C#N)(OC1=O)c1ccccc1)c1ccc(cc1)-c1cc[nH]c(=O)c1 |r|
Show InChI InChI=1S/C28H29N3O3/c1-20(21-9-11-22(12-10-21)23-13-15-30-25(32)17-23)31-16-14-28(34-26(31)33,18-27(2,3)19-29)24-7-5-4-6-8-24/h4-13,15,17,20H,14,16,18H2,1-3H3,(H,30,32)/t20-,28-/m0/s1
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n/an/a 1.11n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH

US Patent


Assay Description
The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...

US Patent US8575157 (2013)


BindingDB Entry DOI: 10.7270/Q2416VPS
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM107633
PNG
(US8575157, 88)
Show SMILES C[C@H](N1CC[C@@](CC(C)(C)O)(OC1=O)c1ccccc1F)c1ccc(cc1)-c1ccn(C2CC2)c(=O)c1 |r|
Show InChI InChI=1S/C30H33FN2O4/c1-20(21-8-10-22(11-9-21)23-14-16-33(24-12-13-24)27(34)18-23)32-17-15-30(37-28(32)35,19-29(2,3)36)25-6-4-5-7-26(25)31/h4-11,14,16,18,20,24,36H,12-13,15,17,19H2,1-3H3/t20-,30-/m0/s1
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n/an/a 1.20n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH

US Patent


Assay Description
The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...

US Patent US8575157 (2013)


BindingDB Entry DOI: 10.7270/Q2416VPS
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM107667
PNG
(US8575157, 74)
Show SMILES CC(C)n1cc(ccc1=O)-c1ccc(cc1)[C@H](C)N1CC[C@@](CC(C)(C)C#C)(OC1=O)c1ccccc1 |r|
Show InChI InChI=1S/C32H36N2O3/c1-7-31(5,6)22-32(28-11-9-8-10-12-28)19-20-33(30(36)37-32)24(4)25-13-15-26(16-14-25)27-17-18-29(35)34(21-27)23(2)3/h1,8-18,21,23-24H,19-20,22H2,2-6H3/t24-,32-/m0/s1
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n/an/a 1.21n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH

US Patent


Assay Description
The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...

US Patent US8575157 (2013)


BindingDB Entry DOI: 10.7270/Q2416VPS
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM107642
PNG
(US8575157, 5)
Show SMILES C[C@H](N1CC[C@@](CC(C)(C)O)(OC1=O)c1ccccc1)c1ccc(cc1)-c1ccn(C(F)F)c(=O)c1 |r|
Show InChI InChI=1S/C28H30F2N2O4/c1-19(20-9-11-21(12-10-20)22-13-15-32(25(29)30)24(33)17-22)31-16-14-28(36-26(31)34,18-27(2,3)35)23-7-5-4-6-8-23/h4-13,15,17,19,25,35H,14,16,18H2,1-3H3/t19-,28-/m0/s1
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n/an/a 1.25n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH

US Patent


Assay Description
The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...

US Patent US8575157 (2013)


BindingDB Entry DOI: 10.7270/Q2416VPS
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM107608
PNG
(US8575157, 57)
Show SMILES CC[C@H](N1CC[C@@](CC)(OC1=O)c1ccccc1)c1ccc(cc1)-c1ccc(=O)n(CC)c1 |r|
Show InChI InChI=1S/C28H32N2O3/c1-4-25(22-14-12-21(13-15-22)23-16-17-26(31)29(6-3)20-23)30-19-18-28(5-2,33-27(30)32)24-10-8-7-9-11-24/h7-17,20,25H,4-6,18-19H2,1-3H3/t25-,28+/m0/s1
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n/an/a 1.26n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH

US Patent


Assay Description
The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...

US Patent US8575157 (2013)


BindingDB Entry DOI: 10.7270/Q2416VPS
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM107488
PNG
(US8575157, 202 | US8592410, Comparator 14 | US8598...)
Show SMILES C[C@H](N1CC[C@@](CCO)(OC1=O)c1ccc(F)cc1)c1ccc(OC(F)F)cc1 |r|
Show InChI InChI=1S/C21H22F3NO4/c1-14(15-2-8-18(9-3-15)28-19(23)24)25-12-10-21(11-13-26,29-20(25)27)16-4-6-17(22)7-5-16/h2-9,14,19,26H,10-13H2,1H3/t14-,21-/m0/s1
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n/an/a 1.30n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH

US Patent


Assay Description
The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...

US Patent US8575157 (2013)


BindingDB Entry DOI: 10.7270/Q2416VPS
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM107593
PNG
(US8575157, 39)
Show SMILES C[C@H](N1CC[C@@](CCCNS(C)(=O)=O)(OC1=O)c1ccccc1)c1ccc(cc1)-c1ccc(=O)n(C)c1 |r|
Show InChI InChI=1S/C28H33N3O5S/c1-21(22-10-12-23(13-11-22)24-14-15-26(32)30(2)20-24)31-19-17-28(36-27(31)33,25-8-5-4-6-9-25)16-7-18-29-37(3,34)35/h4-6,8-15,20-21,29H,7,16-19H2,1-3H3/t21-,28+/m0/s1
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n/an/a 1.31n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH

US Patent


Assay Description
The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...

US Patent US8575157 (2013)


BindingDB Entry DOI: 10.7270/Q2416VPS
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM107604
PNG
(US8575157, 53)
Show SMILES CCn1cc(ccc1=O)-c1ccc(cc1)[C@H](C)N1CC[C@@](CC(C)(C)O)(OC1=O)c1ccccc1 |r|
Show InChI InChI=1S/C29H34N2O4/c1-5-30-19-24(15-16-26(30)32)23-13-11-22(12-14-23)21(2)31-18-17-29(35-27(31)33,20-28(3,4)34)25-9-7-6-8-10-25/h6-16,19,21,34H,5,17-18,20H2,1-4H3/t21-,29-/m0/s1
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n/an/a 1.35n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH

US Patent


Assay Description
The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...

US Patent US8575157 (2013)


BindingDB Entry DOI: 10.7270/Q2416VPS
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM107655
PNG
(US8575157, 29)
Show SMILES C[C@H](N1CC[C@@](CCCO)(OC1=O)c1ccccc1)c1ccc(cc1)-c1ccc(=O)[nH]c1 |r|
Show InChI InChI=1S/C26H28N2O4/c1-19(20-8-10-21(11-9-20)22-12-13-24(30)27-18-22)28-16-15-26(14-5-17-29,32-25(28)31)23-6-3-2-4-7-23/h2-4,6-13,18-19,29H,5,14-17H2,1H3,(H,27,30)/t19-,26+/m0/s1
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n/an/a 1.39n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH

US Patent


Assay Description
The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...

US Patent US8575157 (2013)


BindingDB Entry DOI: 10.7270/Q2416VPS
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM107670
PNG
(US8575157, 87)
Show SMILES CCCn1cc(ccc1=O)-c1ccc(cc1)[C@H](C)N1CC[C@@](CC(C)(C)O)(OC1=O)c1ccccc1 |r|
Show InChI InChI=1S/C30H36N2O4/c1-5-18-31-20-25(15-16-27(31)33)24-13-11-23(12-14-24)22(2)32-19-17-30(36-28(32)34,21-29(3,4)35)26-9-7-6-8-10-26/h6-16,20,22,35H,5,17-19,21H2,1-4H3/t22-,30-/m0/s1
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n/an/a 1.40n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH

US Patent


Assay Description
The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...

US Patent US8575157 (2013)


BindingDB Entry DOI: 10.7270/Q2416VPS
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM107611
PNG
(US8575157, 61)
Show SMILES C[C@H](N1CC[C@@](CC(C)(C)O)(OC1=O)c1ccccc1)c1ccc(cc1)-c1cc(C)c(=O)n(C)c1 |r|
Show InChI InChI=1S/C29H34N2O4/c1-20-17-24(18-30(5)26(20)32)23-13-11-22(12-14-23)21(2)31-16-15-29(35-27(31)33,19-28(3,4)34)25-9-7-6-8-10-25/h6-14,17-18,21,34H,15-16,19H2,1-5H3/t21-,29-/m0/s1
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n/an/a 1.40n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH

US Patent


Assay Description
The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...

US Patent US8575157 (2013)


BindingDB Entry DOI: 10.7270/Q2416VPS
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM107623
PNG
(US8575157, 75)
Show SMILES C[C@H](N1CC[C@@](CC(C)(C)O)(OC1=O)c1ccccc1)c1ccc(cc1)-c1ccn(C2CC2)c(=O)c1 |r|
Show InChI InChI=1S/C30H34N2O4/c1-21(22-9-11-23(12-10-22)24-15-17-32(26-13-14-26)27(33)19-24)31-18-16-30(36-28(31)34,20-29(2,3)35)25-7-5-4-6-8-25/h4-12,15,17,19,21,26,35H,13-14,16,18,20H2,1-3H3/t21-,30-/m0/s1
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US Patent
n/an/a 1.40n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH

US Patent


Assay Description
The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...

US Patent US8575157 (2013)


BindingDB Entry DOI: 10.7270/Q2416VPS
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM107656
PNG
(US8575157, 30)
Show SMILES C[C@H](N1CC[C@@](CCCO)(OC1=O)c1ccccc1)c1ccc(cc1)-c1ccc(=O)n(C)c1 |r|
Show InChI InChI=1S/C27H30N2O4/c1-20(21-9-11-22(12-10-21)23-13-14-25(31)28(2)19-23)29-17-16-27(15-6-18-30,33-26(29)32)24-7-4-3-5-8-24/h3-5,7-14,19-20,30H,6,15-18H2,1-2H3/t20-,27+/m0/s1
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n/an/a 1.44n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH

US Patent


Assay Description
The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...

US Patent US8575157 (2013)


BindingDB Entry DOI: 10.7270/Q2416VPS
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM107483
PNG
(US8575157, 192 | US8592410, Comparator 4 | US85981...)
Show SMILES OCC[C@@]1(CCN(C(=O)O1)c1cccc(n1)-c1ccc(F)cc1)c1ccccc1 |r|
Show InChI InChI=1S/C23H21FN2O3/c24-19-11-9-17(10-12-19)20-7-4-8-21(25-20)26-15-13-23(14-16-27,29-22(26)28)18-5-2-1-3-6-18/h1-12,27H,13-16H2/t23-/m0/s1
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n/an/a 1.44n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH

US Patent


Assay Description
The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...

US Patent US8575157 (2013)


BindingDB Entry DOI: 10.7270/Q2416VPS
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM107616
PNG
(US8575157, 66)
Show SMILES C[C@H](N1CC[C@@](CC(C)(C)O)(OC1=O)c1ccccc1)c1ccc(cc1)-c1ccn(CC(F)(F)F)c(=O)c1 |r|
Show InChI InChI=1S/C29H31F3N2O4/c1-20(21-9-11-22(12-10-21)23-13-15-33(25(35)17-23)19-29(30,31)32)34-16-14-28(38-26(34)36,18-27(2,3)37)24-7-5-4-6-8-24/h4-13,15,17,20,37H,14,16,18-19H2,1-3H3/t20-,28-/m0/s1
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n/an/a 1.47n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH

US Patent


Assay Description
The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...

US Patent US8575157 (2013)


BindingDB Entry DOI: 10.7270/Q2416VPS
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM107484
PNG
(US8575157, 194 | US8592410, Comparator 6 | US85981...)
Show SMILES C[C@H](N1CC[C@@](CC(C)(C)O)(OC1=O)c1ccc(F)cc1)c1ccc(cc1)-c1ccc(F)cc1F |r|
Show InChI InChI=1S/C28H28F3NO3/c1-18(19-4-6-20(7-5-19)24-13-12-23(30)16-25(24)31)32-15-14-28(35-26(32)33,17-27(2,3)34)21-8-10-22(29)11-9-21/h4-13,16,18,34H,14-15,17H2,1-3H3/t18-,28-/m0/s1
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n/an/a 1.48n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH

US Patent


Assay Description
The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...

US Patent US8575157 (2013)


BindingDB Entry DOI: 10.7270/Q2416VPS
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM107588
PNG
(US8575157, 26)
Show SMILES C[C@H](N1CC[C@@](CC(C)(C)O)(OC1=O)c1ccccc1F)c1ccc(cc1)-c1ccn(C)c(=O)c1 |r|
Show InChI InChI=1S/C28H31FN2O4/c1-19(20-9-11-21(12-10-20)22-13-15-30(4)25(32)17-22)31-16-14-28(35-26(31)33,18-27(2,3)34)23-7-5-6-8-24(23)29/h5-13,15,17,19,34H,14,16,18H2,1-4H3/t19-,28-/m0/s1
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n/an/a 1.49n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH

US Patent


Assay Description
The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...

US Patent US8575157 (2013)


BindingDB Entry DOI: 10.7270/Q2416VPS
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM107577
PNG
(US8575157, 1)
Show SMILES C[C@H](N1CC[C@@](CC(C)(C)O)(OC1=O)c1ccccc1)c1ccc(cc1)-c1ccc(=O)[nH]c1 |r|
Show InChI InChI=1S/C27H30N2O4/c1-19(20-9-11-21(12-10-20)22-13-14-24(30)28-17-22)29-16-15-27(33-25(29)31,18-26(2,3)32)23-7-5-4-6-8-23/h4-14,17,19,32H,15-16,18H2,1-3H3,(H,28,30)/t19-,27-/m0/s1
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n/an/a 1.51n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH

US Patent


Assay Description
The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...

US Patent US8575157 (2013)


BindingDB Entry DOI: 10.7270/Q2416VPS
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM107665
PNG
(US8575157, 59)
Show SMILES CC(C)n1cc(ccc1=O)-c1ccc(cc1)[C@H](C)N1CC[C@@](CC(C)(C)O)(OC1=O)c1ccccc1 |r|
Show InChI InChI=1S/C30H36N2O4/c1-21(2)32-19-25(15-16-27(32)33)24-13-11-23(12-14-24)22(3)31-18-17-30(36-28(31)34,20-29(4,5)35)26-9-7-6-8-10-26/h6-16,19,21-22,35H,17-18,20H2,1-5H3/t22-,30-/m0/s1
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n/an/a 1.53n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH

US Patent


Assay Description
The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...

US Patent US8575157 (2013)


BindingDB Entry DOI: 10.7270/Q2416VPS
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM107598
PNG
(US8575157, 45)
Show SMILES C[C@H](N1CC[C@@](CCCO)(OC1=O)c1ccccc1)c1ccc(cc1)-c1cc[nH]c(=O)c1 |r|
Show InChI InChI=1S/C26H28N2O4/c1-19(20-8-10-21(11-9-20)22-12-15-27-24(30)18-22)28-16-14-26(13-5-17-29,32-25(28)31)23-6-3-2-4-7-23/h2-4,6-12,15,18-19,29H,5,13-14,16-17H2,1H3,(H,27,30)/t19-,26+/m0/s1
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n/an/a 1.58n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH

US Patent


Assay Description
The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...

US Patent US8575157 (2013)


BindingDB Entry DOI: 10.7270/Q2416VPS
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM107640
PNG
(US8575157, 3)
Show SMILES C[C@H](N1CC[C@@](CC(C)(C)O)(OC1=O)c1ccccc1)c1ccc(cc1)-c1ccc(=O)n(c1)C1CC1 |r|
Show InChI InChI=1S/C30H34N2O4/c1-21(22-9-11-23(12-10-22)24-13-16-27(33)32(19-24)26-14-15-26)31-18-17-30(36-28(31)34,20-29(2,3)35)25-7-5-4-6-8-25/h4-13,16,19,21,26,35H,14-15,17-18,20H2,1-3H3/t21-,30-/m0/s1
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n/an/a 1.59n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH

US Patent


Assay Description
The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...

US Patent US8575157 (2013)


BindingDB Entry DOI: 10.7270/Q2416VPS
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM107664
PNG
(US8575157, 48)
Show SMILES C[C@H](N1CC[C@@](CC(C)(C)O)(OC1=O)c1ccccc1)c1ccc(cc1)-c1ccn(C)c(=O)c1 |r|
Show InChI InChI=1S/C28H32N2O4/c1-20(21-10-12-22(13-11-21)23-14-16-29(4)25(31)18-23)30-17-15-28(34-26(30)32,19-27(2,3)33)24-8-6-5-7-9-24/h5-14,16,18,20,33H,15,17,19H2,1-4H3/t20-,28-/m0/s1
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n/an/a 1.62n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH

US Patent


Assay Description
The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...

US Patent US8575157 (2013)


BindingDB Entry DOI: 10.7270/Q2416VPS
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM107614
PNG
(US8575157, 64)
Show SMILES C[C@H](N1CC[C@@](CC(C)(C)O)(OC1=O)c1ccccc1)c1ccc(cc1)-c1cc(C)n(C)c(=O)c1 |r|
Show InChI InChI=1S/C29H34N2O4/c1-20-17-24(18-26(32)30(20)5)23-13-11-22(12-14-23)21(2)31-16-15-29(35-27(31)33,19-28(3,4)34)25-9-7-6-8-10-25/h6-14,17-18,21,34H,15-16,19H2,1-5H3/t21-,29-/m0/s1
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n/an/a 1.64n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH

US Patent


Assay Description
The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...

US Patent US8575157 (2013)


BindingDB Entry DOI: 10.7270/Q2416VPS
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM107606
PNG
(US8575157, 55)
Show SMILES CC[C@H](N1CC[C@@](CC(C)(C)O)(OC1=O)c1ccccc1)c1ccc(cc1)-c1ccn(C)c(=O)c1 |r|
Show InChI InChI=1S/C29H34N2O4/c1-5-25(22-13-11-21(12-14-22)23-15-17-30(4)26(32)19-23)31-18-16-29(35-27(31)33,20-28(2,3)34)24-9-7-6-8-10-24/h6-15,17,19,25,34H,5,16,18,20H2,1-4H3/t25-,29-/m0/s1
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n/an/a 1.66n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH

US Patent


Assay Description
The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...

US Patent US8575157 (2013)


BindingDB Entry DOI: 10.7270/Q2416VPS
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM107661
PNG
(US8575157, 37)
Show SMILES C[C@H](N1CC[C@@](CC(C)(C)O)(OC1=O)c1ccccc1)c1ccc(cc1)-c1ccc(=O)n(C)c1 |r|
Show InChI InChI=1S/C28H32N2O4/c1-20(21-10-12-22(13-11-21)23-14-15-25(31)29(4)18-23)30-17-16-28(34-26(30)32,19-27(2,3)33)24-8-6-5-7-9-24/h5-15,18,20,33H,16-17,19H2,1-4H3/t20-,28-/m0/s1
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n/an/a 1.67n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH

US Patent


Assay Description
The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...

US Patent US8575157 (2013)


BindingDB Entry DOI: 10.7270/Q2416VPS
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 341 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%