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PubMed code 11052804

Compile data set for download or QSAR
Found 41 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM27213
PNG
(4-[3-(4-cyclopropanecarbonylphenoxy)propyl]-1H-imi...)
Show SMILES O=C(C1CC1)c1ccc(OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C16H18N2O2/c19-16(12-3-4-12)13-5-7-15(8-6-13)20-9-1-2-14-10-17-11-18-14/h5-8,10-12H,1-4,9H2,(H,17,18)
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0.490n/an/an/an/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Effect on histamine H3 receptors in vitro, on synaptosomes of rat cerebral cortex for the release of [3H]histamine


J Med Chem 43: 3987-94 (2000)

More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM22541
PNG
(CLOBENPROPIT | Clobenpropit | N''-[(4-chlorophenyl...)
Show SMILES NC(SCCCc1cnc[nH]1)=NCc1ccc(Cl)cc1 |w:11.12|
Show InChI InChI=1S/C14H17ClN4S/c15-12-5-3-11(4-6-12)8-18-14(16)20-7-1-2-13-9-17-10-19-13/h3-6,9-10H,1-2,7-8H2,(H2,16,18)(H,17,19)
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0.600n/an/an/an/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Effect on histamine H3 receptors in vitro, on synaptosomes of rat cerebral cortex for the release of [3H]histamine


J Med Chem 43: 3987-94 (2000)

More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50092853
PNG
(1-{4-[3-(1H-Imidazol-4-yl)-propoxy]-phenyl}-propan...)
Show SMILES CCC(=O)c1ccc(OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C15H18N2O2/c1-2-15(18)12-5-7-14(8-6-12)19-9-3-4-13-10-16-11-17-13/h5-8,10-11H,2-4,9H2,1H3,(H,16,17)
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0.740n/an/an/an/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Effect on histamine H3 receptors in vitro, on synaptosomes of rat cerebral cortex for the release of [3H]histamine


J Med Chem 43: 3987-94 (2000)

More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50091386
PNG
(1-{4-[3-(1H-Imidazol-4-yl)-propoxy]-phenyl}-ethano...)
Show SMILES CC(=O)c1ccc(OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C14H16N2O2/c1-11(17)12-4-6-14(7-5-12)18-8-2-3-13-9-15-10-16-13/h4-7,9-10H,2-3,8H2,1H3,(H,15,16)
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0.800n/an/an/an/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Effect on histamine H3 receptors in vitro, on synaptosomes of rat cerebral cortex for the release of [3H]histamine


J Med Chem 43: 3987-94 (2000)

More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50092841
PNG
(CHEMBL128690 | Cyclobutyl-{4-[3-(1H-imidazol-4-yl)...)
Show SMILES O=C(C1CCC1)c1ccc(OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C17H20N2O2/c20-17(13-3-1-4-13)14-6-8-16(9-7-14)21-10-2-5-15-11-18-12-19-15/h6-9,11-13H,1-5,10H2,(H,18,19)
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0.890n/an/an/an/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Effect on histamine H3 receptors in vitro, on synaptosomes of rat cerebral cortex for the release of [3H]histamine


J Med Chem 43: 3987-94 (2000)

More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50092846
PNG
(1-{2-Fluoro-4-[3-(1H-imidazol-4-yl)-propoxy]-pheny...)
Show SMILES CC(=O)c1ccc(OCCCc2cnc[nH]2)cc1F
Show InChI InChI=1S/C14H15FN2O2/c1-10(18)13-5-4-12(7-14(13)15)19-6-2-3-11-8-16-9-17-11/h4-5,7-9H,2-3,6H2,1H3,(H,16,17)
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1.10n/an/an/an/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Effect on histamine H3 receptors in vitro, on synaptosomes of rat cerebral cortex for the release of [3H]histamine


J Med Chem 43: 3987-94 (2000)

More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50092848
PNG
(1-{4-[3-(1H-Imidazol-4-yl)-propoxy]-2-methyl-pheny...)
Show SMILES CC(=O)c1ccc(OCCCc2cnc[nH]2)cc1C
Show InChI InChI=1S/C15H18N2O2/c1-11-8-14(5-6-15(11)12(2)18)19-7-3-4-13-9-16-10-17-13/h5-6,8-10H,3-4,7H2,1-2H3,(H,16,17)
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1.20n/an/an/an/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Effect on histamine H3 receptors in vitro, on synaptosomes of rat cerebral cortex for the release of [3H]histamine


J Med Chem 43: 3987-94 (2000)

More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50092845
PNG
(1-{4-[3-(1H-Imidazol-4-yl)-propoxy]-phenyl}-butan-...)
Show SMILES CCCC(=O)c1ccc(OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C16H20N2O2/c1-2-4-16(19)13-6-8-15(9-7-13)20-10-3-5-14-11-17-12-18-14/h6-9,11-12H,2-5,10H2,1H3,(H,17,18)
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1.90n/an/an/an/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Effect on histamine H3 receptors in vitro, on synaptosomes of rat cerebral cortex for the release of [3H]histamine


J Med Chem 43: 3987-94 (2000)

More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50092844
PNG
(4-[3-(4-Methoxy-phenoxy)-propyl]-1H-imidazole; com...)
Show SMILES COc1ccc(OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C13H16N2O2/c1-16-12-4-6-13(7-5-12)17-8-2-3-11-9-14-10-15-11/h4-7,9-10H,2-3,8H2,1H3,(H,14,15)
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2.20n/an/an/an/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Effect on histamine H3 receptors in vitro, on synaptosomes of rat cerebral cortex for the release of [3H]histamine


J Med Chem 43: 3987-94 (2000)

More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50067472
PNG
(4-[3-(4-Ethynyl-phenoxy)-propyl]-1H-imidazole | 4-...)
Show SMILES C#Cc1ccc(OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C14H14N2O/c1-2-12-5-7-14(8-6-12)17-9-3-4-13-10-15-11-16-13/h1,5-8,10-11H,3-4,9H2,(H,15,16)
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2.30n/an/an/an/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Effect on histamine H3 receptors in vitro, on synaptosomes of rat cerebral cortex for the release of [3H]histamine


J Med Chem 43: 3987-94 (2000)

More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50092843
PNG
(1-{4-[3-(1H-Imidazol-4-yl)-propoxy]-phenyl}-hexan-...)
Show SMILES CCCCCC(=O)c1ccc(OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C18H24N2O2/c1-2-3-4-7-18(21)15-8-10-17(11-9-15)22-12-5-6-16-13-19-14-20-16/h8-11,13-14H,2-7,12H2,1H3,(H,19,20)
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2.5n/an/an/an/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Effect on histamine H3 receptors in vitro, on synaptosomes of rat cerebral cortex for the release of [3H]histamine


J Med Chem 43: 3987-94 (2000)

More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50092838
PNG
(1-{4-[3-(1H-Imidazol-4-yl)-propoxy]-phenyl}-pentan...)
Show SMILES CCCCC(=O)c1ccc(OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C17H22N2O2/c1-2-3-6-17(20)14-7-9-16(10-8-14)21-11-4-5-15-12-18-13-19-15/h7-10,12-13H,2-6,11H2,1H3,(H,18,19)
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2.60n/an/an/an/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Effect on histamine H3 receptors in vitro, on synaptosomes of rat cerebral cortex for the release of [3H]histamine


J Med Chem 43: 3987-94 (2000)

More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM22914
PNG
(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)
Show SMILES S=C(NC1CCCCC1)N1CCC(CC1)c1cnc[nH]1
Show InChI InChI=1S/C15H24N4S/c20-15(18-13-4-2-1-3-5-13)19-8-6-12(7-9-19)14-10-16-11-17-14/h10-13H,1-9H2,(H,16,17)(H,18,20)
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4n/an/an/an/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Effect on histamine H3 receptors in vitro, on synaptosomes of rat cerebral cortex for the release of [3H]histamine


J Med Chem 43: 3987-94 (2000)

More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50092850
PNG
(1-{4-[3-(1H-Imidazol-4-yl)-propoxy]-phenyl}-2-meth...)
Show SMILES CC(C)C(=O)c1ccc(OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C16H20N2O2/c1-12(2)16(19)13-5-7-15(8-6-13)20-9-3-4-14-10-17-11-18-14/h5-8,10-12H,3-4,9H2,1-2H3,(H,17,18)
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4.80n/an/an/an/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Effect on histamine H3 receptors in vitro, on synaptosomes of rat cerebral cortex for the release of [3H]histamine


J Med Chem 43: 3987-94 (2000)

More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50092856
PNG
(1-{4-[3-(1H-Imidazol-4-yl)-propoxy]-3-methyl-pheny...)
Show SMILES CC(=O)c1ccc(OCCCc2cnc[nH]2)c(C)c1
Show InChI InChI=1S/C15H18N2O2/c1-11-8-13(12(2)18)5-6-15(11)19-7-3-4-14-9-16-10-17-14/h5-6,8-10H,3-4,7H2,1-2H3,(H,16,17)
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4.80n/an/an/an/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Effect on histamine H3 receptors in vitro, on synaptosomes of rat cerebral cortex for the release of [3H]histamine


J Med Chem 43: 3987-94 (2000)

More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50092834
PNG
(1-{4-[3-(1H-Imidazol-4-yl)-propoxy]-phenyl}-2-phen...)
Show SMILES O=C(Cc1ccccc1)c1ccc(OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C20H20N2O2/c23-20(13-16-5-2-1-3-6-16)17-8-10-19(11-9-17)24-12-4-7-18-14-21-15-22-18/h1-3,5-6,8-11,14-15H,4,7,12-13H2,(H,21,22)
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5.90n/an/an/an/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Effect on histamine H3 receptors in vitro, on synaptosomes of rat cerebral cortex for the release of [3H]histamine


J Med Chem 43: 3987-94 (2000)

More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50092865
PNG
(1-{4-[3-(1H-Imidazol-4-yl)-propoxy]-phenyl}-heptan...)
Show SMILES CCCCCCC(=O)c1ccc(OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C19H26N2O2/c1-2-3-4-5-8-19(22)16-9-11-18(12-10-16)23-13-6-7-17-14-20-15-21-17/h9-12,14-15H,2-8,13H2,1H3,(H,20,21)
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7n/an/an/an/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Effect on histamine H3 receptors in vitro, on synaptosomes of rat cerebral cortex for the release of [3H]histamine


J Med Chem 43: 3987-94 (2000)

More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50092855
PNG
(CHEMBL129146 | Cyclopentyl-{4-[3-(1H-imidazol-4-yl...)
Show SMILES O=C(C1CCCC1)c1ccc(OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C18H22N2O2/c21-18(14-4-1-2-5-14)15-7-9-17(10-8-15)22-11-3-6-16-12-19-13-20-16/h7-10,12-14H,1-6,11H2,(H,19,20)
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7.20n/an/an/an/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Effect on histamine H3 receptors in vitro, on synaptosomes of rat cerebral cortex for the release of [3H]histamine


J Med Chem 43: 3987-94 (2000)

More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50092863
PNG
(CHEMBL128495 | {4-[3-(1H-Imidazol-4-yl)-propoxy]-p...)
Show SMILES OCc1ccc(OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C13H16N2O2/c16-9-11-3-5-13(6-4-11)17-7-1-2-12-8-14-10-15-12/h3-6,8,10,16H,1-2,7,9H2,(H,14,15)
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8.90n/an/an/an/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Effect on histamine H3 receptors in vitro, on synaptosomes of rat cerebral cortex for the release of [3H]histamine


J Med Chem 43: 3987-94 (2000)

More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50053278
PNG
(4-[3-(1H-Imidazol-4-yl)-propoxy]-benzonitrile | 4-...)
Show SMILES N#Cc1ccc(OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C13H13N3O/c14-8-11-3-5-13(6-4-11)17-7-1-2-12-9-15-10-16-12/h3-6,9-10H,1-2,7H2,(H,15,16)
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12n/an/an/an/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Effect on histamine H3 receptors in vitro, on synaptosomes of rat cerebral cortex for the release of [3H]histamine


J Med Chem 43: 3987-94 (2000)

More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50092836
PNG
(4-[3-(1H-Imidazol-4-yl)-propoxy]-benzaldehyde; com...)
Show SMILES O=Cc1ccc(OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C13H14N2O2/c16-9-11-3-5-13(6-4-11)17-7-1-2-12-8-14-10-15-12/h3-6,8-10H,1-2,7H2,(H,14,15)
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12n/an/an/an/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Effect on histamine H3 receptors in vitro, on synaptosomes of rat cerebral cortex for the release of [3H]histamine


J Med Chem 43: 3987-94 (2000)

More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50092857
PNG
(6-[3-(1H-Imidazol-4-yl)-propoxy]-3,4-dihydro-2H-na...)
Show SMILES O=C1CCCc2cc(OCCCc3cnc[nH]3)ccc12
Show InChI InChI=1S/C16H18N2O2/c19-16-5-1-3-12-9-14(6-7-15(12)16)20-8-2-4-13-10-17-11-18-13/h6-7,9-11H,1-5,8H2,(H,17,18)
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13n/an/an/an/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Effect on histamine H3 receptors in vitro, on synaptosomes of rat cerebral cortex for the release of [3H]histamine


J Med Chem 43: 3987-94 (2000)

More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50092862
PNG
(5-[3-(1H-Imidazol-4-yl)-propoxy]-indan-1-one; comp...)
Show SMILES O=C1CCc2cc(OCCCc3cnc[nH]3)ccc12
Show InChI InChI=1S/C15H16N2O2/c18-15-6-3-11-8-13(4-5-14(11)15)19-7-1-2-12-9-16-10-17-12/h4-5,8-10H,1-3,6-7H2,(H,16,17)
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17n/an/an/an/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Compounds were tested for their effect at histamine H3 receptors in vitro on synaptosomes of rat cerebral cortex for the release of [3H]histamine


J Med Chem 43: 3987-94 (2000)

More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50092849
PNG
(1-{4-[3-(1H-Imidazol-4-yl)-propoxy]-2-trifluoromet...)
Show SMILES CC(=O)c1ccc(OCCCc2cnc[nH]2)cc1C(F)(F)F
Show InChI InChI=1S/C15H15F3N2O2/c1-10(21)13-5-4-12(7-14(13)15(16,17)18)22-6-2-3-11-8-19-9-20-11/h4-5,7-9H,2-3,6H2,1H3,(H,19,20)
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17n/an/an/an/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Effect on histamine H3 receptors in vitro, on synaptosomes of rat cerebral cortex for the release of [3H]histamine


J Med Chem 43: 3987-94 (2000)

More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50092852
PNG
(4-[3-(1H-Imidazol-4-yl)-propoxy]-phenol; compound ...)
Show SMILES Oc1ccc(OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C12H14N2O2/c15-11-3-5-12(6-4-11)16-7-1-2-10-8-13-9-14-10/h3-6,8-9,15H,1-2,7H2,(H,13,14)
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18n/an/an/an/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Effect on histamine H3 receptors in vitro, on synaptosomes of rat cerebral cortex for the release of [3H]histamine


J Med Chem 43: 3987-94 (2000)

More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50092854
PNG
(4-{4-[3-(1H-Imidazol-4-yl)-propoxy]-phenyl}-but-3-...)
Show SMILES CC(=O)C=Cc1ccc(OCCCc2cnc[nH]2)cc1 |w:3.2|
Show InChI InChI=1S/C16H18N2O2/c1-13(19)4-5-14-6-8-16(9-7-14)20-10-2-3-15-11-17-12-18-15/h4-9,11-12H,2-3,10H2,1H3,(H,17,18)
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20n/an/an/an/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Effect on histamine H3 receptors in vitro, on synaptosomes of rat cerebral cortex for the release of [3H]histamine


J Med Chem 43: 3987-94 (2000)

More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50092835
PNG
(1-{4-[3-(1H-Imidazol-4-yl)-propoxy]-phenyl}-3,3-di...)
Show SMILES CC(C)(C)CC(=O)c1ccc(OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C18H24N2O2/c1-18(2,3)11-17(21)14-6-8-16(9-7-14)22-10-4-5-15-12-19-13-20-15/h6-9,12-13H,4-5,10-11H2,1-3H3,(H,19,20)
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27n/an/an/an/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Effect on histamine H3 receptors in vitro, on synaptosomes of rat cerebral cortex for the release of [3H]histamine


J Med Chem 43: 3987-94 (2000)

More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50092847
PNG
(3-{4-[3-(1H-Imidazol-4-yl)-propoxy]-phenyl}-propen...)
Show SMILES O=CC=Cc1ccc(OCCCc2cnc[nH]2)cc1 |w:2.1|
Show InChI InChI=1S/C15H16N2O2/c18-9-1-3-13-5-7-15(8-6-13)19-10-2-4-14-11-16-12-17-14/h1,3,5-9,11-12H,2,4,10H2,(H,16,17)
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32n/an/an/an/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Effect on histamine H3 receptors in vitro, on synaptosomes of rat cerebral cortex for the release of [3H]histamine


J Med Chem 43: 3987-94 (2000)

More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50092837
PNG
(4-[3-(Indan-5-yloxy)-propyl]-1H-imidazole with (0....)
Show SMILES C(COc1ccc2CCCc2c1)Cc1cnc[nH]1
Show InChI InChI=1S/C15H18N2O/c1-3-12-6-7-15(9-13(12)4-1)18-8-2-5-14-10-16-11-17-14/h6-7,9-11H,1-5,8H2,(H,16,17)
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38n/an/an/an/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Effect on histamine H3 receptors in vitro, on synaptosomes of rat cerebral cortex for the release of [3H]histamine


J Med Chem 43: 3987-94 (2000)

More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50092858
PNG
(4-[3-(4-Methanesulfonyl-phenoxy)-propyl]-1H-imidaz...)
Show SMILES CS(=O)(=O)c1ccc(OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C13H16N2O3S/c1-19(16,17)13-6-4-12(5-7-13)18-8-2-3-11-9-14-10-15-11/h4-7,9-10H,2-3,8H2,1H3,(H,14,15)
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40n/an/an/an/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Effect on histamine H3 receptors in vitro, on synaptosomes of rat cerebral cortex for the release of [3H]histamine


J Med Chem 43: 3987-94 (2000)

More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50092864
PNG
(4-[3-(5,6,7,8-Tetrahydro-naphthalen-2-yloxy)-propy...)
Show SMILES C(COc1ccc2CCCCc2c1)Cc1cnc[nH]1
Show InChI InChI=1S/C16H20N2O/c1-2-5-14-10-16(8-7-13(14)4-1)19-9-3-6-15-11-17-12-18-15/h7-8,10-12H,1-6,9H2,(H,17,18)
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45n/an/an/an/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Effect on histamine H3 receptors in vitro, on synaptosomes of rat cerebral cortex for the release of [3H]histamine


J Med Chem 43: 3987-94 (2000)

More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50092859
PNG
(5-{4-[3-(1H-Imidazol-4-yl)-propoxy]-phenyl}-5-oxo-...)
Show SMILES OC(=O)CCCC(=O)c1ccc(OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C17H20N2O4/c20-16(4-1-5-17(21)22)13-6-8-15(9-7-13)23-10-2-3-14-11-18-12-19-14/h6-9,11-12H,1-5,10H2,(H,18,19)(H,21,22)
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49n/an/an/an/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Effect on histamine H3 receptors in vitro, on synaptosomes of rat cerebral cortex for the release of [3H]histamine


J Med Chem 43: 3987-94 (2000)

More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50092860
PNG
(1-{4-[3-(1H-Imidazol-4-yl)-propoxy]-phenyl}-propan...)
Show SMILES CC(=O)Cc1ccc(OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C15H18N2O2/c1-12(18)9-13-4-6-15(7-5-13)19-8-2-3-14-10-16-11-17-14/h4-7,10-11H,2-3,8-9H2,1H3,(H,16,17)
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53n/an/an/an/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Effect on histamine H3 receptors in vitro, on synaptosomes of rat cerebral cortex for the release of [3H]histamine


J Med Chem 43: 3987-94 (2000)

More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50092833
PNG
(4-(3-Phenoxy-propyl)-1H-imidazole with (0.95M)oxal...)
Show SMILES C(COc1ccccc1)Cc1cnc[nH]1
Show InChI InChI=1S/C12H14N2O/c1-2-6-12(7-3-1)15-8-4-5-11-9-13-10-14-11/h1-3,6-7,9-10H,4-5,8H2,(H,13,14)
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55n/an/an/an/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Effect on histamine H3 receptors in vitro, on synaptosomes of rat cerebral cortex for the release of [3H]histamine


J Med Chem 43: 3987-94 (2000)

More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50092840
PNG
(1-{2-Fluoro-4-[3-(1H-imidazol-4-yl)-propoxy]-pheny...)
Show SMILES CCC(=O)c1ccc(OCCCc2cnc[nH]2)cc1F
Show InChI InChI=1S/C15H17FN2O2/c1-2-15(19)13-6-5-12(8-14(13)16)20-7-3-4-11-9-17-10-18-11/h5-6,8-10H,2-4,7H2,1H3,(H,17,18)
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57n/an/an/an/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Effect on histamine H3 receptors in vitro, on synaptosomes of rat cerebral cortex for the release of [3H]histamine


J Med Chem 43: 3987-94 (2000)

More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50092839
PNG
(1-{4-[3-(1H-Imidazol-4-yl)-propoxy]-2,6-dimethyl-p...)
Show SMILES CC(=O)c1c(C)cc(OCCCc2cnc[nH]2)cc1C
Show InChI InChI=1S/C16H20N2O2/c1-11-7-15(8-12(2)16(11)13(3)19)20-6-4-5-14-9-17-10-18-14/h7-10H,4-6H2,1-3H3,(H,17,18)
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90n/an/an/an/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Effect on histamine H3 receptors in vitro, on synaptosomes of rat cerebral cortex for the release of [3H]histamine


J Med Chem 43: 3987-94 (2000)

More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50092866
PNG
(4-{4-[3-(1H-Imidazol-4-yl)-propoxy]-phenyl}-butan-...)
Show SMILES CC(=O)CCc1ccc(OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C16H20N2O2/c1-13(19)4-5-14-6-8-16(9-7-14)20-10-2-3-15-11-17-12-18-15/h6-9,11-12H,2-5,10H2,1H3,(H,17,18)
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91n/an/an/an/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Effect on histamine H3 receptors in vitro, on synaptosomes of rat cerebral cortex for the release of [3H]histamine


J Med Chem 43: 3987-94 (2000)

More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50092851
PNG
(5-{4-[3-(1H-Imidazol-4-yl)-propoxy]-phenyl}-5-oxo-...)
Show SMILES CCOC(=O)CCCC(=O)c1ccc(OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C19H24N2O4/c1-2-24-19(23)7-3-6-18(22)15-8-10-17(11-9-15)25-12-4-5-16-13-20-14-21-16/h8-11,13-14H,2-7,12H2,1H3,(H,20,21)
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122n/an/an/an/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Effect on histamine H3 receptors in vitro, on synaptosomes of rat cerebral cortex for the release of [3H]histamine


J Med Chem 43: 3987-94 (2000)

More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50092861
PNG
(1-{4-[3-(1H-Imidazol-4-yl)-propoxy]-2-methoxy-phen...)
Show SMILES COc1cc(OCCCc2cnc[nH]2)ccc1C(C)=O
Show InChI InChI=1S/C15H18N2O3/c1-11(18)14-6-5-13(8-15(14)19-2)20-7-3-4-12-9-16-10-17-12/h5-6,8-10H,3-4,7H2,1-2H3,(H,16,17)
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325n/an/an/an/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Effect on histamine H3 receptors in vitro, on synaptosomes of rat cerebral cortex for the release of [3H]histamine


J Med Chem 43: 3987-94 (2000)

More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50092867
PNG
(4-(8-Fluoro-1,3,4,5-tetrahydro-pyrido[4,3-b]indol-...)
Show SMILES Fc1ccc2[nH]c3CCN(CCCC(=O)c4ccc(OCCCc5cnc[nH]5)cc4)Cc3c2c1
Show InChI InChI=1S/C27H29FN4O2/c28-20-7-10-25-23(15-20)24-17-32(13-11-26(24)31-25)12-1-4-27(33)19-5-8-22(9-6-19)34-14-2-3-21-16-29-18-30-21/h5-10,15-16,18,31H,1-4,11-14,17H2,(H,29,30)
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410n/an/an/an/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Effect on histamine H3 receptors in vitro, on synaptosomes of rat cerebral cortex for the release of [3H]histamine


J Med Chem 43: 3987-94 (2000)

More data for this
Ligand-Target Pair
Histamine N-methyltransferase


(Rattus norvegicus)
BDBM27213
PNG
(4-[3-(4-cyclopropanecarbonylphenoxy)propyl]-1H-imi...)
Show SMILES O=C(C1CC1)c1ccc(OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C16H18N2O2/c19-16(12-3-4-12)13-5-7-15(8-6-13)20-9-1-2-14-10-17-11-18-14/h5-8,10-12H,1-4,9H2,(H,17,18)
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n/an/a 9.00E+3n/an/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Inhibition against histamine-metabolizing enzyme Histamine N-methyl-transferase


J Med Chem 43: 3987-94 (2000)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%