Found 39 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50358043
(CHEMBL1794051 | GW-5074)Show InChI InChI=1S/C15H10Br2INO2/c16-11-4-7(5-12(17)14(11)20)3-10-9-6-8(18)1-2-13(9)19-15(10)21/h1-6,15,19-21H | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory concentration against raf kinase. |
Bioorg Med Chem Lett 11: 2775-8 (2001)
BindingDB Entry DOI: 10.7270/Q2NS0VD5 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 11/12/13/14
(Homo sapiens (Human)) | BDBM50095423
(5-tert-Butyl-3-(3-phenyl-ureido)-thiophene-2-carbo...)Show InChI InChI=1S/C17H20N2O3S/c1-17(2,3)13-10-12(14(23-13)15(20)22-4)19-16(21)18-11-8-6-5-7-9-11/h5-10H,1-4H3,(H2,18,19,21) | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 290 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibition of Mitogen-activated protein kinase p38 |
Bioorg Med Chem Lett 11: 2775-8 (2001)
BindingDB Entry DOI: 10.7270/Q2NS0VD5 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 11/12/13/14
(Homo sapiens (Human)) | BDBM50105619
(1-(5-tert-Butyl-isoxazol-3-yl)-3-(4-phenoxy-phenyl...)Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccccc3)cc2)no1 Show InChI InChI=1S/C20H21N3O3/c1-20(2,3)17-13-18(23-26-17)22-19(24)21-14-9-11-16(12-10-14)25-15-7-5-4-6-8-15/h4-13H,1-3H3,(H2,21,22,23,24) | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 360 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibition of Escherichia coli derived Mitogen-activated protein kinase p38 |
Bioorg Med Chem Lett 11: 2775-8 (2001)
BindingDB Entry DOI: 10.7270/Q2NS0VD5 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50105619
(1-(5-tert-Butyl-isoxazol-3-yl)-3-(4-phenoxy-phenyl...)Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccccc3)cc2)no1 Show InChI InChI=1S/C20H21N3O3/c1-20(2,3)17-13-18(23-26-17)22-19(24)21-14-9-11-16(12-10-14)25-15-7-5-4-6-8-15/h4-13H,1-3H3,(H2,21,22,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 540 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory concentration against raf kinase. |
Bioorg Med Chem Lett 11: 2775-8 (2001)
BindingDB Entry DOI: 10.7270/Q2NS0VD5 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50105601
(5-tert-Butyl-3-[3-(5-methyl-[1,3,4]thiadiazol-2-yl...)Show InChI InChI=1S/C14H18N4O3S2/c1-7-17-18-13(22-7)16-12(20)15-8-6-9(14(2,3)4)23-10(8)11(19)21-5/h6H,1-5H3,(H2,15,16,18,20) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory concentration against raf kinase. |
Bioorg Med Chem Lett 11: 2775-8 (2001)
BindingDB Entry DOI: 10.7270/Q2NS0VD5 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50095399
(5-tert-Butyl-3-(3-p-tolyl-ureido)-thiophene-2-carb...)Show InChI InChI=1S/C18H22N2O3S/c1-11-6-8-12(9-7-11)19-17(22)20-13-10-14(18(2,3)4)24-15(13)16(21)23-5/h6-10H,1-5H3,(H2,19,20,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory concentration against raf kinase. |
Bioorg Med Chem Lett 11: 2775-8 (2001)
BindingDB Entry DOI: 10.7270/Q2NS0VD5 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50105621
(5-tert-Butyl-3-[3-(5-cyclopropyl-[1,3,4]thiadiazol...)Show SMILES COC(=O)c1sc(cc1NC(=O)Nc1nnc(s1)C1CC1)C(C)(C)C Show InChI InChI=1S/C16H20N4O3S2/c1-16(2,3)10-7-9(11(24-10)13(21)23-4)17-14(22)18-15-20-19-12(25-15)8-5-6-8/h7-8H,5-6H2,1-4H3,(H2,17,18,20,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory concentration against raf kinase. |
Bioorg Med Chem Lett 11: 2775-8 (2001)
BindingDB Entry DOI: 10.7270/Q2NS0VD5 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50105597
(5-tert-Butyl-3-[3-(5-ethyl-[1,3,4]thiadiazol-2-yl)...)Show InChI InChI=1S/C15H20N4O3S2/c1-6-10-18-19-14(24-10)17-13(21)16-8-7-9(15(2,3)4)23-11(8)12(20)22-5/h7H,6H2,1-5H3,(H2,16,17,19,21) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory concentration against raf kinase. |
Bioorg Med Chem Lett 11: 2775-8 (2001)
BindingDB Entry DOI: 10.7270/Q2NS0VD5 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50095396
(5-tert-Butyl-3-(3-p-tolyl-ureido)-furan-2-carboxyl...)Show InChI InChI=1S/C18H22N2O4/c1-11-6-8-12(9-7-11)19-17(22)20-13-10-14(18(2,3)4)24-15(13)16(21)23-5/h6-10H,1-5H3,(H2,19,20,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory concentration against raf kinase. |
Bioorg Med Chem Lett 11: 2775-8 (2001)
BindingDB Entry DOI: 10.7270/Q2NS0VD5 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50095428
(5-tert-Butyl-3-(3-p-tolyl-ureido)-1H-pyrrole-2-car...)Show SMILES COC(=O)c1[nH]c(cc1NC(=O)Nc1ccc(C)cc1)C(C)(C)C Show InChI InChI=1S/C18H23N3O3/c1-11-6-8-12(9-7-11)19-17(23)20-13-10-14(18(2,3)4)21-15(13)16(22)24-5/h6-10,21H,1-5H3,(H2,19,20,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory concentration against raf kinase. |
Bioorg Med Chem Lett 11: 2775-8 (2001)
BindingDB Entry DOI: 10.7270/Q2NS0VD5 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50105606
(5-tert-Butyl-3-[3-(4-methyl-thiophen-2-yl)-ureido]...)Show InChI InChI=1S/C16H20N2O3S2/c1-9-6-12(22-8-9)18-15(20)17-10-7-11(16(2,3)4)23-13(10)14(19)21-5/h6-8H,1-5H3,(H2,17,18,20) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 3.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory concentration against raf kinase. |
Bioorg Med Chem Lett 11: 2775-8 (2001)
BindingDB Entry DOI: 10.7270/Q2NS0VD5 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50105620
(5-tert-Butyl-3-[3-(5-methyl-thiophen-2-yl)-ureido]...)Show InChI InChI=1S/C16H20N2O3S2/c1-9-6-7-12(22-9)18-15(20)17-10-8-11(16(2,3)4)23-13(10)14(19)21-5/h6-8H,1-5H3,(H2,17,18,20) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 3.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory concentration against raf kinase. |
Bioorg Med Chem Lett 11: 2775-8 (2001)
BindingDB Entry DOI: 10.7270/Q2NS0VD5 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50105612
(5-Isopropyl-3-(3-p-tolyl-ureido)-thiophene-2-carbo...)Show InChI InChI=1S/C17H20N2O3S/c1-10(2)14-9-13(15(23-14)16(20)22-4)19-17(21)18-12-7-5-11(3)6-8-12/h5-10H,1-4H3,(H2,18,19,21) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory concentration against raf kinase. |
Bioorg Med Chem Lett 11: 2775-8 (2001)
BindingDB Entry DOI: 10.7270/Q2NS0VD5 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50095403
(1-(5-tert-butyl-2-(methylcarbamoyl)thiophen-3-yl)-...)Show InChI InChI=1S/C18H23N3O2S/c1-11-6-8-12(9-7-11)20-17(23)21-13-10-14(18(2,3)4)24-15(13)16(22)19-5/h6-10H,1-5H3,(H,19,22)(H2,20,21,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 4.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory concentration against raf kinase. |
Bioorg Med Chem Lett 11: 2775-8 (2001)
BindingDB Entry DOI: 10.7270/Q2NS0VD5 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50105599
(5-Bromomethyl-3-(3-p-tolyl-ureido)-thiophene-2-car...)Show InChI InChI=1S/C15H15BrN2O3S/c1-9-3-5-10(6-4-9)17-15(20)18-12-7-11(8-16)22-13(12)14(19)21-2/h3-7H,8H2,1-2H3,(H2,17,18,20) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory concentration against raf kinase. |
Bioorg Med Chem Lett 11: 2775-8 (2001)
BindingDB Entry DOI: 10.7270/Q2NS0VD5 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50095414
(5-tert-Butyl-3-(3-p-tolyl-ureido)-thiophene-2-carb...)Show SMILES CCOC(=O)c1sc(cc1NC(=O)Nc1ccc(C)cc1)C(C)(C)C Show InChI InChI=1S/C19H24N2O3S/c1-6-24-17(22)16-14(11-15(25-16)19(3,4)5)21-18(23)20-13-9-7-12(2)8-10-13/h7-11H,6H2,1-5H3,(H2,20,21,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory concentration against raf kinase. |
Bioorg Med Chem Lett 11: 2775-8 (2001)
BindingDB Entry DOI: 10.7270/Q2NS0VD5 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50105615
(5-tert-Butyl-3-[3-(5-trifluoromethyl-[1,3,4]thiadi...)Show SMILES COC(=O)c1sc(cc1NC(=O)Nc1nnc(s1)C(F)(F)F)C(C)(C)C Show InChI InChI=1S/C14H15F3N4O3S2/c1-13(2,3)7-5-6(8(25-7)9(22)24-4)18-11(23)19-12-21-20-10(26-12)14(15,16)17/h5H,1-4H3,(H2,18,19,21,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 6.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory concentration against raf kinase. |
Bioorg Med Chem Lett 11: 2775-8 (2001)
BindingDB Entry DOI: 10.7270/Q2NS0VD5 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50105613
(5-tert-Butyl-3-[3-(1-methyl-1H-pyrazol-3-yl)-ureid...)Show InChI InChI=1S/C15H20N4O3S/c1-15(2,3)10-8-9(12(23-10)13(20)22-5)16-14(21)17-11-6-7-19(4)18-11/h6-8H,1-5H3,(H2,16,17,18,21) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 6.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory concentration against raf kinase. |
Bioorg Med Chem Lett 11: 2775-8 (2001)
BindingDB Entry DOI: 10.7270/Q2NS0VD5 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50095420
(5-tert-Butyl-3-[3-(4-chloro-phenyl)-ureido]-thioph...)Show SMILES COC(=O)c1sc(cc1NC(=O)Nc1ccc(Cl)cc1)C(C)(C)C Show InChI InChI=1S/C17H19ClN2O3S/c1-17(2,3)13-9-12(14(24-13)15(21)23-4)20-16(22)19-11-7-5-10(18)6-8-11/h5-9H,1-4H3,(H2,19,20,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 6.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory concentration against raf kinase. |
Bioorg Med Chem Lett 11: 2775-8 (2001)
BindingDB Entry DOI: 10.7270/Q2NS0VD5 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50105598
(5-tert-Butyl-3-[3-(1-ethyl-1H-pyrrol-3-yl)-ureido]...)Show InChI InChI=1S/C17H23N3O3S/c1-6-20-8-7-11(10-20)18-16(22)19-12-9-13(17(2,3)4)24-14(12)15(21)23-5/h7-10H,6H2,1-5H3,(H2,18,19,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 7.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory concentration against raf kinase. |
Bioorg Med Chem Lett 11: 2775-8 (2001)
BindingDB Entry DOI: 10.7270/Q2NS0VD5 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50095394
(5-tert-Butyl-3-[3-(3,4-dichloro-phenyl)-ureido]-fu...)Show SMILES COC(=O)c1oc(cc1NC(=O)Nc1ccc(Cl)c(Cl)c1)C(C)(C)C Show InChI InChI=1S/C17H18Cl2N2O4/c1-17(2,3)13-8-12(14(25-13)15(22)24-4)21-16(23)20-9-5-6-10(18)11(19)7-9/h5-8H,1-4H3,(H2,20,21,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 7.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory concentration against raf kinase. |
Bioorg Med Chem Lett 11: 2775-8 (2001)
BindingDB Entry DOI: 10.7270/Q2NS0VD5 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50105596
(5-tert-Butyl-3-[3-(1-ethyl-1H-pyrazol-3-yl)-ureido...)Show InChI InChI=1S/C16H22N4O3S/c1-6-20-8-7-12(19-20)18-15(22)17-10-9-11(16(2,3)4)24-13(10)14(21)23-5/h7-9H,6H2,1-5H3,(H2,17,18,19,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 8.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory concentration against raf kinase. |
Bioorg Med Chem Lett 11: 2775-8 (2001)
BindingDB Entry DOI: 10.7270/Q2NS0VD5 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50105614
(5-tert-Butyl-3-[3-(1-isopropyl-1H-pyrrol-3-yl)-ure...)Show SMILES COC(=O)c1sc(cc1NC(=O)Nc1ccn(c1)C(C)C)C(C)(C)C Show InChI InChI=1S/C18H25N3O3S/c1-11(2)21-8-7-12(10-21)19-17(23)20-13-9-14(18(3,4)5)25-15(13)16(22)24-6/h7-11H,1-6H3,(H2,19,20,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 8.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory concentration against raf kinase. |
Bioorg Med Chem Lett 11: 2775-8 (2001)
BindingDB Entry DOI: 10.7270/Q2NS0VD5 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50105604
(5-tert-Butyl-3-[3-(5-tert-butyl-[1,3,4]thiadiazol-...)Show SMILES COC(=O)c1sc(cc1NC(=O)Nc1nnc(s1)C(C)(C)C)C(C)(C)C Show InChI InChI=1S/C17H24N4O3S2/c1-16(2,3)10-8-9(11(25-10)12(22)24-7)18-14(23)19-15-21-20-13(26-15)17(4,5)6/h8H,1-7H3,(H2,18,19,21,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory concentration against raf kinase. |
Bioorg Med Chem Lett 11: 2775-8 (2001)
BindingDB Entry DOI: 10.7270/Q2NS0VD5 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50105602
(5-tert-Butyl-3-[3-(1-propyl-1H-pyrrol-3-yl)-ureido...)Show SMILES CCCn1ccc(NC(=O)Nc2cc(sc2C(=O)OC)C(C)(C)C)c1 Show InChI InChI=1S/C18H25N3O3S/c1-6-8-21-9-7-12(11-21)19-17(23)20-13-10-14(18(2,3)4)25-15(13)16(22)24-5/h7,9-11H,6,8H2,1-5H3,(H2,19,20,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory concentration against raf kinase. |
Bioorg Med Chem Lett 11: 2775-8 (2001)
BindingDB Entry DOI: 10.7270/Q2NS0VD5 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50105610
(5-tert-Butyl-3-(3-thiophen-2-yl-ureido)-thiophene-...)Show InChI InChI=1S/C15H18N2O3S2/c1-15(2,3)10-8-9(12(22-10)13(18)20-4)16-14(19)17-11-6-5-7-21-11/h5-8H,1-4H3,(H2,16,17,19) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory concentration against raf kinase. |
Bioorg Med Chem Lett 11: 2775-8 (2001)
BindingDB Entry DOI: 10.7270/Q2NS0VD5 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50105617
(3-[3-(1-Benzyl-1H-pyrazol-3-yl)-ureido]-5-tert-but...)Show SMILES COC(=O)c1sc(cc1NC(=O)Nc1ccn(Cc2ccccc2)n1)C(C)(C)C Show InChI InChI=1S/C21H24N4O3S/c1-21(2,3)16-12-15(18(29-16)19(26)28-4)22-20(27)23-17-10-11-25(24-17)13-14-8-6-5-7-9-14/h5-12H,13H2,1-4H3,(H2,22,23,24,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory concentration against raf kinase. |
Bioorg Med Chem Lett 11: 2775-8 (2001)
BindingDB Entry DOI: 10.7270/Q2NS0VD5 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50105607
(5-tert-Butyl-3-[3-(3,4-dichloro-phenyl)-ureido]-1H...)Show SMILES COC(=O)c1[nH]c(cc1NC(=O)Nc1ccc(Cl)c(Cl)c1)C(C)(C)C Show InChI InChI=1S/C17H19Cl2N3O3/c1-17(2,3)13-8-12(14(22-13)15(23)25-4)21-16(24)20-9-5-6-10(18)11(19)7-9/h5-8,22H,1-4H3,(H2,20,21,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory concentration against raf kinase. |
Bioorg Med Chem Lett 11: 2775-8 (2001)
BindingDB Entry DOI: 10.7270/Q2NS0VD5 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50105611
(1-(2-(aminomethyl)-5-tert-butylthiophen-3-yl)-3-p-...)Show InChI InChI=1S/C17H23N3OS/c1-11-5-7-12(8-6-11)19-16(21)20-13-9-15(17(2,3)4)22-14(13)10-18/h5-9H,10,18H2,1-4H3,(H2,19,20,21) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| PubMed
| n/a | n/a | 1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory concentration against raf kinase. |
Bioorg Med Chem Lett 11: 2775-8 (2001)
BindingDB Entry DOI: 10.7270/Q2NS0VD5 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50105600
(5-tert-Butyl-3-[3-(3,4-dimethyl-phenyl)-ureido]-th...)Show SMILES COC(=O)c1sc(cc1NC(=O)Nc1ccc(C)c(C)c1)C(C)(C)C Show InChI InChI=1S/C19H24N2O3S/c1-11-7-8-13(9-12(11)2)20-18(23)21-14-10-15(19(3,4)5)25-16(14)17(22)24-6/h7-10H,1-6H3,(H2,20,21,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory concentration against raf kinase. |
Bioorg Med Chem Lett 11: 2775-8 (2001)
BindingDB Entry DOI: 10.7270/Q2NS0VD5 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50095411
(5-tert-Butyl-3-[3-(4-hydroxy-phenyl)-ureido]-thiop...)Show InChI InChI=1S/C17H20N2O4S/c1-17(2,3)13-9-12(14(24-13)15(21)23-4)19-16(22)18-10-5-7-11(20)8-6-10/h5-9,20H,1-4H3,(H2,18,19,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory concentration against raf kinase. |
Bioorg Med Chem Lett 11: 2775-8 (2001)
BindingDB Entry DOI: 10.7270/Q2NS0VD5 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50105618
(1-(5-tert-butyl-2-(dimethylcarbamoyl)thiophen-3-yl...)Show SMILES CN(C)C(=O)c1sc(cc1NC(=O)Nc1ccc(C)cc1)C(C)(C)C Show InChI InChI=1S/C19H25N3O2S/c1-12-7-9-13(10-8-12)20-18(24)21-14-11-15(19(2,3)4)25-16(14)17(23)22(5)6/h7-11H,1-6H3,(H2,20,21,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory concentration against raf kinase. |
Bioorg Med Chem Lett 11: 2775-8 (2001)
BindingDB Entry DOI: 10.7270/Q2NS0VD5 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50105608
(5-tert-Butyl-3-[3-(1-isopropyl-1H-pyrazol-3-yl)-ur...)Show SMILES COC(=O)c1sc(cc1NC(=O)Nc1ccn(n1)C(C)C)C(C)(C)C Show InChI InChI=1S/C17H24N4O3S/c1-10(2)21-8-7-13(20-21)19-16(23)18-11-9-12(17(3,4)5)25-14(11)15(22)24-6/h7-10H,1-6H3,(H2,18,19,20,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory concentration against raf kinase. |
Bioorg Med Chem Lett 11: 2775-8 (2001)
BindingDB Entry DOI: 10.7270/Q2NS0VD5 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50095423
(5-tert-Butyl-3-(3-phenyl-ureido)-thiophene-2-carbo...)Show InChI InChI=1S/C17H20N2O3S/c1-17(2,3)13-10-12(14(23-13)15(20)22-4)19-16(21)18-11-8-6-5-7-9-11/h5-10H,1-4H3,(H2,18,19,21) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory concentration against raf kinase. |
Bioorg Med Chem Lett 11: 2775-8 (2001)
BindingDB Entry DOI: 10.7270/Q2NS0VD5 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50095395
(3-[3-(4-Amino-phenyl)-ureido]-5-tert-butyl-thiophe...)Show InChI InChI=1S/C17H21N3O3S/c1-17(2,3)13-9-12(14(24-13)15(21)23-4)20-16(22)19-11-7-5-10(18)6-8-11/h5-9H,18H2,1-4H3,(H2,19,20,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 1.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory concentration against raf kinase. |
Bioorg Med Chem Lett 11: 2775-8 (2001)
BindingDB Entry DOI: 10.7270/Q2NS0VD5 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50105605
(5-tert-Butyl-3-[3-(1-propyl-1H-pyrazol-3-yl)-ureid...)Show SMILES CCCn1ccc(NC(=O)Nc2cc(sc2C(=O)OC)C(C)(C)C)n1 Show InChI InChI=1S/C17H24N4O3S/c1-6-8-21-9-7-13(20-21)19-16(23)18-11-10-12(17(2,3)4)25-14(11)15(22)24-5/h7,9-10H,6,8H2,1-5H3,(H2,18,19,20,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory concentration against raf kinase. |
Bioorg Med Chem Lett 11: 2775-8 (2001)
BindingDB Entry DOI: 10.7270/Q2NS0VD5 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50105603
(5-tert-Butyl-3-[3-(3,4-dichloro-phenyl)-ureido]-th...)Show SMILES COC(=O)c1sc(cc1NC(=O)Nc1ccc(Cl)c(Cl)c1)C(C)(C)C Show InChI InChI=1S/C17H18Cl2N2O3S/c1-17(2,3)13-8-12(14(25-13)15(22)24-4)21-16(23)20-9-5-6-10(18)11(19)7-9/h5-8H,1-4H3,(H2,20,21,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory concentration against raf kinase. |
Bioorg Med Chem Lett 11: 2775-8 (2001)
BindingDB Entry DOI: 10.7270/Q2NS0VD5 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50105616
(5-tert-Butyl-3-(3-m-tolyl-ureido)-thiophene-2-carb...)Show InChI InChI=1S/C18H22N2O3S/c1-11-7-6-8-12(9-11)19-17(22)20-13-10-14(18(2,3)4)24-15(13)16(21)23-5/h6-10H,1-5H3,(H2,19,20,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory concentration against raf kinase. |
Bioorg Med Chem Lett 11: 2775-8 (2001)
BindingDB Entry DOI: 10.7270/Q2NS0VD5 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50105609
(5-tert-Butyl-3-[3-(3-chloro-phenyl)-ureido]-thioph...)Show SMILES COC(=O)c1sc(cc1NC(=O)Nc1cccc(Cl)c1)C(C)(C)C Show InChI InChI=1S/C17H19ClN2O3S/c1-17(2,3)13-9-12(14(24-13)15(21)23-4)20-16(22)19-11-7-5-6-10(18)8-11/h5-9H,1-4H3,(H2,19,20,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 2.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory concentration against raf kinase. |
Bioorg Med Chem Lett 11: 2775-8 (2001)
BindingDB Entry DOI: 10.7270/Q2NS0VD5 |
More data for this
Ligand-Target Pair | |
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