362 articles for thisTarget

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The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
28134521	8	Phloroglucinol Derivatives with Protein Tyrosine Phosphatase 1B Inhibitory Activities from Eugenia jambolana Seeds.	Northeastern University
28109786	1	A tetramic acid derivative with protein tyrosine phosphatase 1B inhibitory activity and a new nortriterpene glycoside from the Indonesian marine sponge Petrosia sp.	Tohoku Medical and Pharmaceutical University
28111140	24	Discovery of core-structurally novel PTP1B inhibitors with specific selectivity containing oxindole-fused spirotetrahydrofurochroman by one-pot reaction.	East China Normal University
28189419	20	Furanoterpenes, new types of protein tyrosine phosphatase 1B inhibitors, from two Indonesian marine sponges, Ircinia and Spongia spp.	Tohoku Medical and Pharmaceutical University
27842892	18	Discovery of 4-[(5-arylidene-4-oxothiazolidin-3-yl)methyl]benzoic acid derivatives active as novel potent allosteric inhibitors of protein tyrosine phosphatase 1B: In silico studies and in vitro evaluation as insulinomimetic and anti-inflammatory agents.	University of Messina
28202316	3	An epigenetic modifier induces production of (10'S)-verruculide B, an inhibitor of protein tyrosine phosphatases by Phoma sp. nov. LG0217, a fungal endophyte of Parkinsonia microphylla.	University of Arizona
28340988	9	Rational design, synthesis, and structure-activity relationships of 5-amino-1H-pyrazole-4-carboxylic acid derivatives as protein tyrosine phosphatase 1B inhibitors.	Advinus Therapeutics
27526040	21	Design and synthesis of new potent PTP1B inhibitors with the skeleton of 2-substituted imino-3-substituted-5-heteroarylidene-1,3-thiazolidine-4-one: Part I.	Xi'An Jiaotong University
27336796	11	Sesquiterpene Hydroquinones with Protein Tyrosine Phosphatase 1B Inhibitory Activities from a Dysidea sp. Marine Sponge Collected in Okinawa.	Tohoku Medical and Pharmaceutical University
27142786	11	Eucarobustols A-I, Conjugates of Sesquiterpenoids and Acylphloroglucinols from Eucalyptus robusta.	Chinese Academy of Sciences
27123900	17	Discovery of novel, high potent, ABC type PTP1B inhibitors with TCPTP selectivity and cellular activity.	Qilu University of Technology
27353889	34	The design strategy of selective PTP1B inhibitors over TCPTP.	Chinese Academy of Sciences
26841168	9	Bioactive Constituents of Glycyrrhiza uralensis (Licorice): Discovery of the Effective Components of a Traditional Herbal Medicine.	Peking University
26961283	10	In vitro and in silico PTP-1B inhibition and in vivo antidiabetic activity of semisynthetic moronic acid derivatives.	Universidad Aut£Noma Del Estado De Morelos
26965864	5	Novel Imbricatolic acid derivatives as protein tyrosine phosphatase-1B inhibitors: Design, synthesis, biological evaluation and molecular docking.	University of Lucknow
26774579	140	Design, synthesis and in vitro activity of phidianidine B derivatives as novel PTP1B inhibitors with specific selectivity.	Shanghai Institute of Materia Medica
26704263	17	Novel chromenedione derivatives displaying inhibition of protein tyrosine phosphatase 1B (PTP1B) from Flemingia philippinensis.	Qiqihar University
26711144	4	A dimeric urea of the bisabolene sesquiterpene from the Okinawan marine sponge Axinyssa sp. inhibits protein tyrosine phosphatase 1B activity in Huh-7 human hepatoma cells.	Tohoku Pharmaceutical University
26481657	20	Novel, potent, selective and cellular active ABC type PTP1B inhibitors containing (methanesulfonyl-phenyl-amino)-acetic acid methyl ester phosphotyrosine mimetic.	Qilu University of Technology
26396684	15	Identification of Bidentate Salicylic Acid Inhibitors of PTP1B.	University of Toronto Mississauga
26348881	54	Identification of Substituted Naphthotriazolediones as Novel Tryptophan 2,3-Dioxygenase (TDO) Inhibitors through Structure-Based Virtual Screening.	National Health Research Institutes
26342135	39	Synthesis, biological evaluation and 3D-QSAR studies of imidazolidine-2,4-dione derivatives as novel protein tyrosine phosphatase 1B inhibitors.	Tianjin Medical University
26253631	8	Strongylophorines, new protein tyrosine phosphatase 1B inhibitors, from the marine sponge Strongylophora strongilata collected at Iriomote Island.	Tohoku Pharmaceutical University
26191366	66	Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 Inhibitors.	Indiana University School of Medicine
26115570	4	Verruculides A and B, two new protein tyrosine phosphatase 1B inhibitors from an Indonesian ascidian-derived Penicillium verruculosum.	Tohoku Pharmaceutical University
25264584	20	Synthesis of oleanolic acid derivatives: In vitro, in vivo and in silico studies for PTP-1B inhibition.	Universidad Aut£Noma Del Estado De Morelos
25162754	2	Structure-based optimization of a peptidyl inhibitor against calcineurin-nuclear factor of activated T cell (NFAT) interaction.	The Ohio State University
26117648	5	Crystal structures of the apo form and a complex of human LMW-PTP with a phosphonic acid provide new evidence of a secondary site potentially related to the anchorage of natural substrates.	University of Campinas
26100442	17	Discovery of novel, potent, selective and cellular active ADC type PTP1B inhibitors via fragment-docking-oriented de novel design.	Qilu University of Technology
25907369	17	Selaginellin and biflavonoids as protein tyrosine phosphatase 1B inhibitors from Selaginella tamariscina and their glucose uptake stimulatory effects.	Catholic University of Daegu
25890697	6	Thiazolidine-2,4-dione derivatives: programmed chemical weapons for key protein targets of various pathological conditions.	Punjabi University
26083682	12	Structures and Biological Evaluations of Agelasines Isolated from the Okinawan Marine Sponge Agelas nakamurai.	Tohoku Pharmaceutical University
25835537	5	Steroidal Alkaloids from Veratrum nigrum Enhance Glucose Uptake in Skeletal Muscle Cells.	Chungnam National University
25938987	49	Is RK-682 a promiscuous enzyme inhibitor? Synthesis and in vitro evaluation of protein tyrosine phosphatase inhibition of racemic RK-682 and analogues.	University of Campinas
25921264	21	Perspective: Tyrosine phosphatases as novel targets for antiplatelet therapy.	Sanford-Burnham Medical Research Institute
25907367	6	Light-switched inhibitors of protein tyrosine phosphatase PTP1B based on phosphonocarbonyl phenylalanine as photoactive phosphotyrosine mimetic.	Freie Universit£T Berlin
25907364	29	A potent and selective inhibitor for the UBLCP1 proteasome phosphatase.	Indiana University
25703307	30	Synthesis and biological evaluation of 3-aminoisoquinolin-1(2H)-one based inhibitors of the dual-specificity phosphatase Cdc25B.	University of Pittsburgh
25638569	3	Chalcones and their therapeutic targets for the management of diabetes: structural and pharmacological perspectives.	Guru Ghasidas Vishwavidyalaya (A Central University)
25891102	14	PTP1B inhibitors from stems of Angelica keiskei (Ashitaba).	Chinese Academy of Sciences
25872983	57	Design and synthesis of novel 1,2-dithiolan-4-yl benzoate derivatives as PTP1B inhibitors.	Chinese Academy of Sciences
25819098	13	Canthinone alkaloids are novel protein tyrosine phosphatase 1B inhibitors.	Toho University
25600405	7	Absolute structures and bioactivities of euryspongins and eurydiene obtained from the marine sponge Euryspongia sp. collected at Iriomote Island.	Tohoku Pharmaceutical University
25595683	3	Two new protein tyrosine phosphatase 1B inhibitors, hyattellactones A and B, from the Indonesian marine sponge Hyattella sp.	Tohoku Pharmaceutical University
25559759	12	Insulin-mimetic selaginellins from Selaginella tamariscina with protein tyrosine phosphatase 1B (PTP1B) inhibitory activity.	Catholic University of Daegu
25124112	54	Synthesis and biological evaluation of novel thiadiazole amides as potent Cdc25B and PTP1B inhibitors.	Liaoning Normal University
25064350	5	Discovery of diethyl 2,5-diaminothiophene-3,4-dicarboxylate derivatives as potent anticancer and antimicrobial agents and screening of anti-diabetic activity: synthesis and in vitro biological evaluation. Part 1.	Chinese Academy of Sciences
25003231	59	Therapeutic potential of targeting the oncogenic SHP2 phosphatase.	Indiana University School of Medicine
24953600	35	Design, synthesis and docking study of 5-(substituted benzylidene)thiazolidine-2,4-dione derivatives as inhibitors of protein tyrosine phosphatase 1B.	Chonnam National University
24906513	21	4-Quinolone-3-carboxylic acids as cell-permeable inhibitors of protein tyrosine phosphatase 1B.	Chinese Academy of Sciences
25497963	19	Bioactive constituents from the green alga Caulerpa racemosa.	Nanchang University
25453820	2	Tanzawaic acid derivatives from a marine isolate of Penicillium sp. (SF-6013) with anti-inflammatory and PTP1B inhibitory activities.	Wonkwang University
25372368	58	Fast identification of novel lymphoid tyrosine phosphatase inhibitors using target-ligand interaction-based virtual screening.	Shandong University
24840014	25	Ingol-type diterpenes from Euphorbia antiquorum with mouse 11ß-hydroxysteroid dehydrogenase type 1 inhibition activity.	Lanzhou University
24593120	5	Highly conjugated norditerpenoid and pyrroloquinoline alkaloids with potent PTP1B inhibitory activity from Nigella glandulifera.	Chinese Academy of Sciences
24721313	21	Synthesis and evaluation of several oleanolic acid glycoconjugates as protein tyrosine phosphatase 1B inhibitors.	North-West University
24287560	61	Synthesis, biological activity and structure-activity relationships of new benzoic acid-based protein tyrosine phosphatase inhibitors endowed with insulinomimetic effects in mouse C2C12 skeletal muscle cells.	University of Messina
24224843	11	Protein tyrosine phosphatase 1B (PTP1B) inhibitors from Morinda citrifolia (Noni) and their insulin mimetic activity.	Chosun University
24185377	6	Design, synthesis and molecular modelling studies of novel 3-acetamido-4-methyl benzoic acid derivatives as inhibitors of protein tyrosine phosphatase 1B.	School of Pharmaceutical Sciences
24148325	8	Discovery of novel PTP1B inhibitors via pharmacophore-oriented scaffold hopping from Ertiprotafib.	Chinese Academy of Medical Sciences and Peking Union Medical College
24090912	54	Design, synthesis, and biological evaluation of novel 2-ethyl-5-phenylthiazole-4-carboxamide derivatives as protein tyrosine phosphatase 1B inhibitors with improved cellular efficacy.	Chinese Academy of Sciences
24047800	19	Evaluation of licorice flavonoids as protein tyrosine phosphatase 1B inhibitors.	Toho University
24012179	30	Calix[4]arene methylenebisphosphonic acids as inhibitors of protein tyrosine phosphatase 1B.	National Academy of Sciences of Ukraine
23957426	14	Identification of cryptotanshinone as an inhibitor of oncogenic protein tyrosine phosphatase SHP2 (PTPN11).	Case Western Reserve University
23942421	43	The first synthesis of natural disulfide bruguiesulfurol and biological evaluation of its derivatives as a novel scaffold for PTP1B inhibitors.	Chinese Academy of Sciences
23859780	5	Cembrane diterpenoids from the soft coral Sarcophyton trocheliophorum Marenzeller as a new class of PTP1B inhibitors.	Chinese Academy of Sciences
23713581	75	A potent and selective small-molecule inhibitor for the lymphoid-specific tyrosine phosphatase (LYP), a target associated with autoimmune diseases.	Indiana University School of Medicine
23644196	3	Discovery of novel bromophenol 3,4-dibromo-5-(2-bromo-3,4-dihydroxy-6-(isobutoxymethyl)benzyl)benzene-1,2-diol as protein tyrosine phosphatase 1B inhibitor and its anti-diabetic properties in C57BL/KsJ-db/db mice.	Chinese Academy of Sciences
23531458	6	Synthesis and biological evaluation of oleanolic acid derivatives as PTP1B inhibitors.	North-West University
23528300	48	Design and synthesis of 2-substituted benzoxazoles as novel PTP1B inhibitors.	Aurigene Discovery Technologies
23499238	15	Design, synthesis and insulin-sensitising effects of novel PTP1B inhibitors.	Chinese Academy of Medical Sciences and Peking Union Medical College
23434422	2	Euryspongins A-C, three new unique sesquiterpenes from a marine sponge Euryspongia sp.	Tohoku Pharmaceutical University
23387824	18	Sesquiterpenes from the rhizomes of Curcuma heyneana.	University of Toyama
23357636	4	Bioactive polyhydroxylated steroids from the Hainan soft coral Sinularia depressa Tixier-Durivault.	Chinese Academy of Sciences
23305444	171	Discovery and evaluation of novel inhibitors of mycobacterium protein tyrosine phosphatase B from the 6-Hydroxy-benzofuran-5-carboxylic acid scaffold.	Indiana University School of Medicine
23177789	16	Protein tyrosine phosphatase 1B inhibitory effect by dammarane-type triterpenes from hydrolyzate of total Gynostemma pentaphyllum saponins.	Shenyang Pharmaceutical University
20452766	96	Studies on two types of PTP1B inhibitors for the treatment of type 2 diabetes: Hologram QSAR for OBA and BBB analogues.	Tsinghua University
19385614	303	Large-scale application of high-throughput molecular mechanics with Poisson-Boltzmann surface area for routine physics-based scoring of protein-ligand complexes.	Abbott Laboratories
15537353	59	Building predictive models for protein tyrosine phosphatase 1B inhibitors based on discriminating structural features by reassembling medicinal chemistry building blocks.	Leadscope
14561096	16	Finding discriminating structural features by reassembling common building blocks.	Leadscope
22546204	9	Recent developments and biological activities of thiazolidinone derivatives: a review.	Dr. Hari Singh Gour University
23141910	2	New diterpene furanoids from the Antarctic lichen Huea sp.	Silla University
23141909	46	Design and synthesis of novel bis-thiazolone derivatives as micromolar CDC25 phosphatase inhibitors: effect of dimerisation on phosphatase inhibition.	University of Paris
23122867	27	7-Phenyl-pyrido[2,3-d]pyrimidine-2,4-diamines: novel and highly selective protein tyrosine phosphatase 1B inhibitors.	Roche Research Center
23122522	25	Discovery of di-indolinone as a novel scaffold for protein tyrosine phosphatase 1B inhibitors.	East China University of Science and Technology
23067554	37	Synthesis and biological evaluation of 4,4-dimethyl lithocholic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B.	East China Normal University
22341243	6	Synthesis of propiophenone derivatives as new class of antidiabetic agents reducing body weight in db/db mice.	Central Drug Research Institute
23022281	7	New prenylated isoflavonoids as protein tyrosine phosphatase 1B (PTP1B) inhibitors from Erythrina addisoniae.	Chosun University
21988196	15	Low molecular weight phosphotyrosine protein phosphatases as emerging targets for the design of novel therapeutic agents.	University of Messina
21453996	20	Antidiabetic activity of some pentacyclic acid triterpenoids, role of PTP-1B: in vitro, in silico, and in vivo approaches.	Universidad Aut£Noma Del Estado De Morelos
23043764	70	Design, synthesis, and evaluation of 2-substituted ethenesulfonic acid ester derivatives as protein tyrosine phosphatase 1B inhibitors.	Shanghai Jiao Tong University
22940448	8	Rhododendric acid A, a new ursane-type PTP1B inhibitor from the endangered plant Rhododendron brachycarpum G. Don.	Yeungnam University
22690646	6	Structure and bioassay of triterpenoids and steroids isolated from Sinocalamus affinis.	Chinese Academy of Medical Sciences and Peking Union Medical College
22506091	151	Dual-Specificity Phosphatase CDC25A/B Inhibitor Identified from a Focused Library with Nonelectrophilic Core Structure.	TBA
22705189	24	Arylstibonic acids are potent and isoform-selective inhibitors of Cdc25a and Cdc25b phosphatases.	Imperial College
22583779	6	Synthesis, in vitro and in silico screening of ethyl 2-(6-substituted benzo[d]thiazol-2-ylamino)-2-oxoacetates as protein-tyrosine phosphatase 1B inhibitors.	Universidad Aut£Noma Del Estado De Morelos
22444684	9	Bromophenols as inhibitors of protein tyrosine phosphatase 1B with antidiabetic properties.	Chinese Academy of Sciences
22424978	23	Discovery of novel and potent heterocyclic carboxylic acid derivatives as protein tyrosine phosphatase 1B inhibitors.	Advinus Therapeutics
22381357	41	New 4-[(5-arylidene-2-arylimino-4-oxo-3-thiazolidinyl)methyl]benzoic acids active as protein tyrosine phosphatase inhibitors endowed with insulinomimetic effect on mouse C2C12 skeletal muscle cells.	University of Messina
22133902	9	Bicyclic benzofuran and indole-based salicylic acids as protein tyrosine phosphatase inhibitors.	Indiana University
20724155	7	Prenylflavonoids from Glycyrrhiza uralensis and their protein tyrosine phosphatase-1B inhibitory activities.	Toho University
20462762	19	Inhibition of Mycobacterium tuberculosis tyrosine phosphatase PtpA by synthetic chalcones: kinetics, molecular modeling, toxicity and effect on growth.	Universidade Federal De Santa Catarina
19836230	17	Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica.	Chosun University
20153651	37	Novel thiophene derivatives as PTP1B inhibitors with selectivity and cellular activity.	Chinese Academy of Sciences
19846295	8	Protein tyrosine phosphatase 1B inhibitors isolated from Morus bombycis.	Korea Research Institute of Bioscience and Biotechnology
19632832	15	Inhibitory effect of chalcones and their derivatives from Glycyrrhiza inflata on protein tyrosine phosphatase 1B.	Institute
19269068	11	Structure-based virtual screening approach to identify novel classes of PTP1B inhibitors.	Sejong University
19362837	10	Protein tyrosine phosphatase 1B inhibitory effects of depsidone and pseudodepsidone metabolites from the Antarctic lichen Stereocaulon alpinum.	Silla University
19008110	18	Flavanones from the stem bark of Erythrina abyssinica.	Korea Research Institute of Bioscience and Biotechnology (Kribb)
18798681	17	Triterpenoids from the leaves of Diospyros kaki (persimmon) and their inhibitory effects on protein tyrosine phosphatase 1B.	Chosun University
18993066	12	Beta-C-glycosiduronic acids and beta-C-glycosyl compounds: new PTP1B inhibitors.	Cnrs
18555687	14	A re-examination of the difluoromethylenesulfonic acid group as a phosphotyrosine mimic for PTP1B inhibition.	University of Waterloo
17125223	15	Protein tyrosine phosphatase-1B inhibitory activity of isoprenylated flavonoids isolated from Erythrina mildbraedii.	Korea Research Institute of Bioscience and Biotechnology
18288807	5	Usimines A-C, bioactive usnic acid derivatives from the Antarctic lichen Stereocaulon alpinum.	Silla University
18056643	8	Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases.	Indiana University School of Medicine
18372175	45	PTP1B inhibitors: synthesis and evaluation of difluoro-methylenephosphonate bioisosteres on a sulfonamide scaffold.	Affymax
18053716	6	Ohioensins F and G: protein tyrosine phosphatase 1B inhibitory benzonaphthoxanthenones from the Antarctic moss Polytrichastrum alpinum.	Silla University
18477508	39	Discovery of [(3-bromo-7-cyano-2-naphthyl)(difluoro)methyl]phosphonic acid, a potent and orally active small molecule PTP1B inhibitor.	Merck Frosst Centre For Therapeutic Research
17728130	36	2-O-carboxymethylpyrogallol derivatives as PTP1B inhibitors with antihyperglycemic activity.	Inha University
17543532	46	5-Arylidene-2,4-thiazolidinediones as inhibitors of protein tyrosine phosphatases.	Universit£
17596944	10	Design, synthesis, and discovery of stilbene derivatives based on lithospermic acid B as potent protein tyrosine phosphatase 1B inhibitors.	Yonsei University
17368023	24	Methylenedisalicylic acid derivatives: new PTP1B inhibitors that confer resistance to diet-induced obesity.	Inha University
17489632	15	Isoprenylated flavonoids from the stem bark of Erythrina abyssinica.	Korea Research Institute of Bioscience and Biotechnology
16545563	9	Inhibition of protein tyrosine phosphatase 1B by diterpenoids isolated from Acanthopanax koreanum.	Korea Research Institute of Bioscience and Biotechnology
16580200	13	Protein tyrosine phosphatase 1B inhibitory activity of triterpenes isolated from Astilbe koreana.	Korea Research Institute of Bioscience and Biotechnology
15380203	3	Development of a polyvalent assay system for lead identification.	Wyeth Research
15214773	76	Fragment-based drug discovery.	Sunesis Pharmaceuticals
12014959	11	Molecular docking and high-throughput screening for novel inhibitors of protein tyrosine phosphatase-1B.	Pfizer
11741477	37	Structure of protein tyrosine phosphatase 1B in complex with inhibitors bearing two phosphotyrosine mimetics.	University of Waterloo
9379439	16	A model for binding of structurally diverse natural product inhibitors of protein phosphatases PP1 and PP2A.	University of California
15050628	26	Evans Blue and other dyes as protein tyrosine phosphatase inhibitors.	Inha University
11814804	9	The first two cantharidin analogues displaying PP1 selectivity.	The University of Newcastle
12419386	5	Synthesis of [difluoro-(3-alkenylphenyl)-methyl]-phosphonic acids on non-crosslinked polystyrene and their evaluation as inhibitors of PTP1B.	University of Waterloo
11677131	42	Cantharimides: a new class of modified cantharidin analogues inhibiting protein phosphatases 1 and 2A.	The University of Newcastle
10743947	12	Synthesis and characterization of a novel class of protein tyrosine phosphatase inhibitors.	New York University
9871682	19	Naphthalenebis[alpha,alpha-difluoromethylenephosphonates] as potent inhibitors of protein tyrosine phosphatases.	University of Toronto
	7	The conserved acid binding domain model of inhibitors of protein phosphatases 1 and 2A: Molecular modelling aspects.	TBA
22318165	85	Exploration ofa-aminophosphonate N-derivatives as novel, potent and selective inhibitors of protein tyrosine phosphatases.	Shanxi University
22136336	55	Synthesis, biological evaluation, and molecular modeling of chalcone derivatives as potent inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatases (PtpA and PtpB).	Universidade Federal De Santa Catarina
22189136	25	Discovery of potent, selective and orally bioavailable triaryl-sulfonamide based PTP1B inhibitors.	M.S. University of Baroda
22197396	57	Novel (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids: peroxisome proliferator-activated receptor¿ selective agonists with protein-tyrosine phosphatase 1B inhibition.	Kyoto Pharmaceutical Industries
22044245	4	Cucurbitane glucosides from the root of Machilus yaoshansis.	State Key Laboratory of Bioactive Substance and Function of Natural Medicines, and Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine
21882820	72	Small molecule receptor protein tyrosine phosphatase¿ (RPTP¿) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop.	Bristol-Myers Squibb Research and Development
21745700	20	Click to a focused library of benzyl 6-triazolo(hydroxy)benzoic glucosides: novel construction of PTP1B inhibitors on a sugar scaffold.	East China University of Science and Technology
21680062	77	Synthesis and biological evaluation of (±)-3-(2-(2-fluorobenzyloxy) naphthalen-6-yl)-2-aminopropanoic acid derivatives as novel PTP1B inhibitors.	Yanbian University
21571537	14	New 5-deoxyflavonoids and their inhibitory effects on protein tyrosine phosphatase 1B (PTP1B) activity.	Chosun University
20850970	27	Novel thiazolidinedione derivatives with anti-obesity effects: dual action as PTP1B inhibitors and PPAR-¿ activators.	Inha University
21669525	18	Small molecule inhibitors of SHP2 tyrosine phosphatase discovered by virtual screening.	Indiana University
21696953	3	Pyrrolo[2,3-c]azepine derivatives: a new class of potent protein tyrosine phosphatase 1B inhibitors.	Sun Yat-Sen University
21665482	62	Facile fabrication of promising protein tyrosine phosphatase (PTP) inhibitor entities based on 'clicked' serine/threonine-monosaccharide hybrids.	East China University of Science and Technology
19500993	42	Design and synthesis of 3,5-diarylisoxazole derivatives as novel class of anti-hyperglycemic and lipid lowering agents.	Central Drug Research Institute
21548579	4	Hippolides A-H, acyclic manoalide derivatives from the marine sponge Hippospongia lachne.	Second Military Medical University
21555221	44	Design, synthesis, and evaluation of bromo-retrochalcone derivatives as protein tyrosine phosphatase 1B inhibitors.	Chonnam National University
21443195	9	Utilization of nitrophenylphosphates and oxime-based ligation for the development of nanomolar affinity inhibitors of the Yersinia pestis outer protein H (YopH) phosphatase.	National Cancer Institute-Frederick
21420867	68	Using small molecules to target protein phosphatases.	Max Planck Institute of Molecular Physiology
21251827	60	A unique and rapid approach toward the efficient development of novel protein tyrosine phosphatase (PTP) inhibitors based on 'clicked' pseudo-glycopeptides.	East China University of Science and Technology
21190368	60	Inhibition of lymphoid tyrosine phosphatase by benzofuran salicylic acids.	Sanford-Burnham Medical Research Institute
21193311	22	Shp2 protein tyrosine phosphatase inhibitor activity of estramustine phosphate and its triterpenoid analogs.	H. Lee Moffitt Cancer Center and Research Institute
20964318	4	Synthesis and biological evaluation of oleanolic acid derivatives as inhibitors of protein tyrosine phosphatase 1B.	Xihua University
20731359	29	A focused library of protein tyrosine phosphatase inhibitors.	Brown University
20627471	54	Synthesis and evaluation of some novel dibenzo[b,d]furan carboxylic acids as potential anti-diabetic agents.	Glenmark Research Center
20806783	2	Bioactivity-guided isolation of 1,2,3,4,6-Penta-O-galloyl-D-glucopyranose from Paeonia lactiflora roots as a PTP1B inhibitor.	University of Vienna
20472439	37	Dammaranes from Gynostemma pentaphyllum and synthesis of their derivatives as inhibitors of protein tyrosine phosphatase 1B.	Chinese Academy of Sciences
20471838	9	Design and synthesis of 2,4-disubstituted polyhydroquinolines as prospective antihyperglycemic and lipid modulating agents.	Central Drug Research Institute
20363629	49	Discovery and structural optimization of pyrazole derivatives as novel inhibitors of Cdc25B.	Chinese Academy of Sciences
19889539	49	Fragment-based discovery of selective inhibitors of the Mycobacterium tuberculosis protein tyrosine phosphatase PtpA.	University of California
19811915	11	Pyranocoumarins: a new class of anti-hyperglycemic and anti-dyslipidemic agents.	Central Drug Research Institute
19782562	10	Isolation of the protein tyrosine phosphatase 1B inhibitory metabolite from the marine-derived fungus Cosmospora sp. SF-5060.	Silla University
19702283	1	Chemical Constituents of the Roots of Euphorbia micractina.	Chinese Academy of Medical Sciences and Peking Union Medical College
19476336	4	Chemical constituents from the aerial parts of Artemisia minor.	Chinese Academy of Sciences
20000419	51	Recent advances in the discovery of competitive protein tyrosine phosphatase 1B inhibitors for the treatment of diabetes, obesity, and cancer.	Incyte
20170098	21	Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2).	Indiana University School of Medicine
19888758	55	Multidentate small-molecule inhibitors of vaccinia H1-related (VHR) phosphatase decrease proliferation of cervix cancer cells.	Institute For Medical Research
19846303	59	Synthesis and biological evaluation of heterocyclic ring-substituted maslinic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B.	East China Normal University
19810703	102	Knowledge-based characterization of similarity relationships in the human protein-tyrosine phosphatase family for rational inhibitor design.	University of Miami
19783142	27	Thiazolidinedione derivatives as PTP1B inhibitors with antihyperglycemic and antiobesity effects.	Inha University
19500977	20	Structure-based virtual screening approach to identify novel classes of Cdc25B phosphatase inhibitors.	Sejong University
19349096	81	Synthesis and evaluation of some novel isochroman carboxylic acid derivatives as potential anti-diabetic agents.	Glenmark Research Center
	75	Synthesis and phosphatase inhibitory activity of analogs of sulfircin	TBA
19362487	4	Synthesis, in vitro and computational studies of protein tyrosine phosphatase 1B inhibition of a small library of 2-arylsulfonylaminobenzothiazoles with antihyperglycemic activity.	Universidad AutóNoma Del Estado De Morelos
19303291	4	5,6-Diarylanthranilo-1,3-dinitriles as a new class of antihyperglycemic agents.	Central Drug Research Institute
19297174	41	Synthesis, activity and molecular modeling of a new series of chromones as low molecular weight protein tyrosine phosphatase inhibitors.	University of Modena and R.E.
19282172	3	Synthesis of protein tyrosine phosphatase 1B inhibitors: model validation and docking studies.	Central Drug Research Institute
19217304	44	5-Arylidene-2-phenylimino-4-thiazolidinones as PTP1B and LMW-PTP inhibitors.	University of Messina
19091557	2	A novel sesquiterpene quinone from Hainan sponge Dysidea villosa.	Chinese Academy of Sciences
18922697	5	Synthesis of triazole-linked beta-C-glycosyl dimers as inhibitors of PTP1B.	Cnrs
18722777	37	Derivatives of 1,4-bis(3-hydroxycarbonyl-4-hydroxyl)styrylbenzene as PTP1B inhibitors with hypoglycemic activity.	Inha University
18707891	152	Oleanolic acid and its derivatives: new inhibitor of protein tyrosine phosphatase 1B with cellular activities.	Chinese Academy of Sciences
18595691	1	Oxidative inactivation of protein tyrosine phosphatase 1B by organic hydroperoxides.	University of Missouri-Columbia
18579388	18	Illudalic acid as a potential LAR inhibitor: synthesis, SAR, and preliminary studies on the mechanism of action.	Chinese Academy of Sciences
18436346	28	Novel 2-aryl-naphtho[1,2-d]oxazole derivatives as potential PTP-1B inhibitors showing antihyperglycemic activities.	Central Drug Research Institute
17897956	3	Lateral compartmentalization of T cell receptor versus CD45 by galectin-N-glycan binding and microfilaments coordinate basal and activation signaling.	University of California
18037290	66	Isothiazolidinone inhibitors of PTP1B containing imidazoles and imidazolines.	Incyte
17949055	2	Vanillic acid derivatives from the green algae Cladophora socialis as potent protein tyrosine phosphatase 1B inhibitors.	Griffith University
17931864	18	2-Aryl-3,3,3-trifluoro-2-hydroxypropionic acids: a new class of protein tyrosine phosphatase 1B inhibitors.	Heriot-Watt University
17705360	76	Structure-based optimization of protein tyrosine phosphatase 1B inhibitors: from the active site to the second phosphotyrosine binding site.	Wyeth Research
17692525	33	Mono- and disalicylic acid derivatives: PTP1B inhibitors as potential anti-obesity drugs.	Inha University
17517504	6	Inhibitory effect of 2-arylbenzofurans from Erythrina addisoniae on protein tyrosine phosphatase-1B.	Korea Research Institute of Bioscience and Biotechnology
17407812	2	PTP1B inhibitor Ertiprotafib is also a potent inhibitor of IkappaB kinase beta (IKK-beta).	Inha University
17394300	35	Development of molecular probes for second-site screening and design of protein tyrosine phosphatase inhibitors.	Institute For Medical Research
17336064	44	Probing acid replacements of thiophene PTP1B inhibitors.	Wyeth Research
17279797	2	Structures, biogenesis, and biological activities of pyrano[4,3-c]isochromen-4-one derivatives from the Fungus Phellinus igniarius.	Chinese Academy of Medical Sciences and Peking Union Medical College
17249650	1	Synthesis and cell-based activity of a potent and selective protein tyrosine phosphatase 1B inhibitor prodrug.	Purdue University
17095232	20	Synthesis of benzofuran scaffold-based potential PTP-1B inhibitors.	Central Drug Research Institute
16884299	18	Brunsvicamides A-C: sponge-related cyanobacterial peptides with Mycobacterium tuberculosis protein tyrosine phosphatase inhibitory activity.	University of Bonn
16789735	57	Potent benzimidazole sulfonamide protein tyrosine phosphatase 1B inhibitors containing the heterocyclic (S)-isothiazolidinone phosphotyrosine mimetic.	Incyte
16759857	59	Design and synthesis of potent, non-peptidic inhibitors of HPTPbeta.	Procter & Gamble Pharmaceuticals
16716588	9	A gatekeeper residue for inhibitor sensitization of protein tyrosine phosphatases.	Amherst College
16563751	1	Two novel aromatic valerenane-type sesquiterpenes from the Chinese green alga Caulerpa taxifolia.	Chinese Academy of Sciences
16460930	10	Synthesis of novel benzofuran isoxazolines as protein tyrosine phosphatase 1B inhibitors.	Central Drug Research Institute
16434190	48	Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases.	Graduate School of Chinese Academy of Sciences
16356713	14	Protein tyrosine phosphatase 1B inhibitors from Morus root bark.	Korea Research Institute of Bioscience and Biotechnology (Kribb)
16289879	34	PTP-1B inhibitors: cyclopenta[d][1,2]-oxazine derivatives.	Korea Research Institute of Chemical Technology
16236508	35	3-Substituted indolizine-1-carbonitrile derivatives as phosphatase inhibitors.	Technische UniversitäT MüNchen
16220970	7	Structure-based design and discovery of protein tyrosine phosphatase inhibitors incorporating novel isothiazolidinone heterocyclic phosphotyrosine mimetics.	Incyte
16046123	41	Discovery and structure-activity relationships of novel sulfonamides as potent PTP1B inhibitors.	Affymax
16039123	32	Synthesis of tripeptides as potent Yersinia protein tyrosine phosphatase inhibitors.	Nih
15863305	5	Structure-based design of protein tyrosine phosphatase-1B inhibitors.	Astrazeneca
15293983	3	Prospects for inhibitors of protein tyrosine phosphatase 1B as antidiabetic drugs.	Serono Pharmaceutical Research Institute
15013020	94	Structure based design of a series of potent and selective non peptidic PTP-1B inhibitors.	Merck Frosst Centre For Therapeutic Research
15013019	47	The development of potent non-peptidic PTP-1B inhibitors.	Merck Frosst Centre For Therapeutic Research
14611852	34	Identification of a novel class of orally active pyrimido[5,4-3][1,2,4]triazine-5,7-diamine-based hypoglycemic agents with protein tyrosine phosphatase inhibitory activity.	Roche Research Center
13678400	9	Fragment screening and assembly: a highly efficient approach to a selective and cell active protein tyrosine phosphatase 1B inhibitor.	Abbott Laboratories
12951078	38	Discovery and SAR of novel, potent and selective protein tyrosine phosphatase 1B inhibitors.	Abbott Laboratories
12941322	12	Acylsulfonamide-containing PTP1B inhibitors designed to mimic an enzyme-bound water of hydration.	Nih
12877578	33	Selective protein tyrosine phosphatase 1B inhibitors: targeting the second phosphotyrosine binding site with non-carboxylic acid-containing ligands.	Abbott Laboratories
12852970	28	Tripeptide inhibitors of Yersinia protein-tyrosine phosphatase.	National Cancer Institute-Frederick
12852966	23	Formylchromone derivatives as a novel class of protein tyrosine phosphatase 1B inhibitors.	Inha University
12617932	10	Modification of the N-terminus of peptidomimetic protein tyrosine phosphatase 1B (PTP1B) inhibitors: identification of analogues with cellular activity.	Pharmacia
12419367	5	Natural PTP1B inhibitors from Broussonetia papyrifera.	Chinese Academy of Sciences
12372498	23	alpha-bromoacetophenone derivatives as neutral protein tyrosine phosphatase inhibitors: structure-Activity relationship.	The Ohio State University
12238924	145	Discovery and SAR of a novel selective and orally bioavailable nonpeptide classical competitive inhibitor class of protein-tyrosine phosphatase 1B.	Novo Nordisk
12190316	15	Divalent and trivalent alpha-ketocarboxylic acids as inhibitors of protein tyrosine phosphatases.	Brown University
12113814	60	Synthesis and PTP1B inhibition of 1,2-naphthoquinone derivatives as potent anti-diabetic agents.	Korea Research Institute of Chemical Technology
11960490	3	Investigation of potential bioisosteric replacements for the carboxyl groups of peptidomimetic inhibitors of protein tyrosine phosphatase 1B: identification of a tetrazole-containing inhibitor with cellular activity.	Biovitrum
11708908	55	Discovery and biological evaluation of a new family of potent inhibitors of the dual specificity protein phosphatase Cdc25.	University of Pittsburgh
11520195	19	Utilization of a peptide lead for the discovery of a novel PTP1B-binding motif.	National Cancer Institute-Frederick
11459664	21	alpha-Ketocarboxylic acid-based inhibitors of protein tyrosine phosphatases.	Brown University
32787087	215	Highly Potent and Selective	Purdue University
32631548	15	A chalcone derivative binds a putative allosteric site of YopH: Inhibition of a virulence factor of Yersinia.	Universidade Federal De Santa Catarina
32008883	41	Anti-diabetic drugs recent approaches and advancements.	Mizoram University
11356112	175	Potent reversible inhibitors of the protein tyrosine phosphatase CD45.	Astrazeneca Pharmaceuticals
32273218	21	Synthesis and biological evaluation of heterocyclic bis-aryl amides as novel Src homology 2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitors.	Jiangnan University
32298122	11	Naphthacemycins from a	Hebei Medical University
32255628	20	PTP1B-Inhibiting Branched-Chain Fatty Acid Dimers from	University of Copenhagen
11212099	107	Sulfonylated aminothiazoles as new small molecule inhibitors of protein phosphatases.	University of Pittsburgh
31898904	5	?-Glucosidase and Protein Tyrosine Phosphatase 1B Inhibitors from	University of North Carolina Greensboro
32196343	19	Prenylated Phenolic Compounds from the Aerial Parts of	Peking University
31924496	7	Spirobiflavonoid stereoisomers from the endangered conifer Glyptostrobus pensilis and their protein tyrosine phosphatase 1B inhibitory activity.	Fudan University
11128645	16	Synthesis and characterization of a potent and selective protein tyrosine phosphatase inhibitor, 2.	Taisho Pharmaceutical
31944695	23	Stilbenes with Potent Protein Tyrosine Phosphatase-1B Inhibitory Activity from the Roots of	Kyungpook National University
26960032	15	Identification of PTP1B and ?-Glucosidase Inhibitory Serrulatanes from Eremophila spp. by Combined use of Dual High-Resolution PTP1B and ?-Glucosidase Inhibition Profiling and HPLC-HRMS-SPE-NMR.	University of Copenhagen
31307888	15	Tapping the therapeutic potential of protein tyrosine phosphatase 4A with small molecule inhibitors.	University of Pittsburgh
31221555	48	Identification and characterization of potent and selective inhibitors targeting protein tyrosine phosphatase 1B (PTP1B).	Zhejiang Sci-Tech University
10915044	4	Synthesis and PTP1B inhibition of novel 4-aryl-1-oxa-9-thiacyclopenta[b]fluorenes.	Wyeth-Ayerst Research
27064611	3	Structure and Configuration of Phosphoeleganin, a Protein Tyrosine Phosphatase 1B Inhibitor from the Mediterranean Ascidian Sidnyum elegans.	University of Naples Federico Ii
10853661	25	Examination of novel non-phosphorus-containing phosphotyrosyl mimetics against protein-tyrosine phosphatase-1B and demonstration of differential affinities toward Grb2 SH2 domains.	National Cancer Institute-Bethesda
30737132	39	Synthesis, biological evaluation, and molecular docking study of novel allyl-retrochalcones as a new class of protein tyrosine phosphatase 1B inhibitors.	Wenzhou Medical University
30704811	17	Calixarene-based phosphinic acids as inhibitors of protein tyrosine phosphatases.	V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of The National Academy of Sciences of Ukraine
30611982	64	Investigation of stereoisomeric bisarylethenesulfonic acid esters for discovering potent and selective PTP1B inhibitors.	Shanghai Jiao Tong University (Sjtu)
10753467	118	Novel benzofuran and benzothiophene biphenyls as inhibitors of protein tyrosine phosphatase 1B with antihyperglycemic properties.	Wyeth-Ayerst Research
31738062	22	Psiguadiols A-J, Rearranged Meroterpenoids as Potent PTP1B Inhibitors from	China Pharmaceutical University
31618031	28	Protein Tyrosine Phosphatase 1B Inhibitory Iridoids from	University of Illinois At Chicago
10715163	35	New azolidinediones as inhibitors of protein tyrosine phosphatase 1B with antihyperglycemic properties.	Wyeth-Ayerst Research
31532203	24	Cinerols, Nitrogenous Meroterpenoids from the Marine Sponge	Shanghai Jiao Tong University
31469560	20	Indole-Diterpenoids with Protein Tyrosine Phosphatase Inhibitory Activities from the Marine-Derived Fungus	Hebei University
30711829	54	Toward a treatment of diabesity: In vitro and in vivo evaluation of uncharged bromophenol derivatives as a new series of PTP1B inhibitors.	Chinese Academy of Sciences
10464006	22	PTP1B inhibition and antihyperglycemic activity in the ob/ob mouse model of novel 11-arylbenzo[b]naphtho[2,3-d]furans and 11-arylbenzo[b]naphtho[2,3-d]thiophenes.	Wyeth-Ayerst Research
31095389	29	Diketopiperazine-Type Alkaloids from a Deep-Sea-Derived Aspergillus puniceus Fungus and Their Effects on Liver X Receptor ?.	Chinese Academy of Sciences
31047750	845	Dual-targeting GroEL/ES chaperonin and protein tyrosine phosphatase B (PtpB) inhibitors: A polypharmacology strategy for treating Mycobacterium tuberculosis infections.	Indiana University School of Medicine
30448416	4	Benzofuran derivatives and their anti-tubercular, anti-bacterial activities.	Huanghuai University
10098656	13	Synthesis and biological evaluation of alpha,alpha-difluorobenzylphosphonic acid derivatives as small molecular inhibitors of protein-tyrosine phosphatase 1B.	Tokyo University of Pharmacy & Life Science
10091683	12	Periodinates: a new class of protein tyrosine phosphatase inhibitors.	Mcgill University
30525586	14	Celastrol Promotes Weight Loss in Diet-Induced Obesity by Inhibiting the Protein Tyrosine Phosphatases PTP1B and TCPTP in the Hypothalamus.	Helmholtz Zentrum M�Nchen
9873717	12	Novel phosphate mimetics for the design of non-peptidyl inhibitors of protein tyrosine phosphatases.	University of Toronto
30501963	4	BH3 mimetics derived from Bim-BH3 domain core region show PTP1B inhibitory activity.	Ocean University of China
29400967	136	Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design.	Bristol-Myers Squibb
9873503	4	Potent inhibition of protein-tyrosine phosphatase-1B using the phosphotyrosyl mimetic fluoro-O-malonyl tyrosine (FOMT).	National Cancer Institute-Bethesda
30830783	13	Potential Anticancer Agents Characterized from Selected Tropical Plants.	The Ohio State University
30978561	50	Synthesis and biological evaluation of tryptophan-derived rhodanine derivatives as PTP1B inhibitors and anti-bacterial agents.	Yanbian University College of Pharmacy
30342956	44	An investigation on 4-thiazolidinone derivatives as dual inhibitors of aldose reductase and protein tyrosine phosphatase 1B, in the search for potential agents for the treatment of type 2 diabetes mellitus and its complications.	University of Messina
30910462	53	Discovery of 1,3-diphenyl-1H-pyrazole derivatives containing rhodanine-3-alkanoic acid groups as potential PTP1B inhibitors.	Yanbian University
30739823	8	An overview of grayanane diterpenoids and their biological activities from the Ericaceae family in the last seven years.	Northwest A & F University
8676336	2	4'-O-[2-(2-fluoromalonyl)]-L-tyrosine: a phosphotyrosyl mimic for the preparation of signal transduction inhibitory peptides.	National Cancer Institute-Bethesda
26230724	10	New Frontiers in Druggability.	Stony Brook University
25505942	8	Diversity-Oriented Synthesis for Novel, Selective and Drug-like Inhibitors for a Phosphatase from Mycobacterium Tuberculosis.	Indiana University School of Medicine
20961755	5	Highly brominated metabolites from marine red alga Laurencia similis inhibit protein tyrosine phosphatase 1B.	Jilin University
19061360	1	Lipidyl pseudopteranes A-F: isolation, biomimetic synthesis, and PTP1B inhibitory activity of a new class of pseudopteranoids from the Gorgonian Pseudopterogorgia acerosa.	University of Prince Edward Island
18627201	4	Sesquiterpenes from the Hainan Sponge Dysidea septosa.	Chinese Academy of Sciences
16989529	3	Oculatol, oculatolide, and A-nor sterols from the sponge Haliclona oculata.	Peking University
16230012	39	Molecular docking and 3D-QSAR on 2-(oxalylamino) benzoic acid and its analogues as protein tyrosine phosphatase 1B inhibitors.	Graduate University of Chinese Academy of Sciences
30389409	33	Synthetic thiosemicarbazones as a new class of Mycobacterium tuberculosis protein tyrosine phosphatase A inhibitors.	Universidade Federal De Santa Catarina
29275231	9	Development of inhibitors of receptor protein tyrosine phosphatase ?/? (PTPRZ1) as candidates for CNS disorders.	Universidad San Pablo-Ceu
29275228	58	Naturally occurring Diels-Alder-type adducts from Morus nigra as potent inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B.	Universidade Federal De Santa Catarina
30289713	1	Structurally Diverse Sesquiterpenoids from the Endangered Ornamental Plant Michelia shiluensis.	Chinese Academy of Sciences
30207720	8	Dihydrochalcone Glucosides from the Subaerial Parts of Thonningia sanguinea and Their in Vitro PTP1B Inhibitory Activities.	University of Innsbruck
30153005	46	Structure-Based Design of MptpB Inhibitors That Reduce Multidrug-Resistant Mycobacterium tuberculosis Survival and Infection Burden in Vivo.	University of Manchester
30067363	8	Enantiomeric Pairs of Meroterpenoids with Diverse Heterocyclic Systems from Rhododendron nyingchiense.	Fudan University
29525218	13	Identification of caffeoylquinic acid derivatives as natural protein tyrosine phosphatase 1B inhibitors from Artemisia princeps.	China Pharmaceutical University
29306546	52	Inhibition of protein tyrosine phosphatase 1B (PTP1B) and ?-glucosidase by xanthones from Cratoxylum cochinchinense, and their kinetic characterization.	Gyeongsang National University
29100798	21	Benzo[c][1,2,5]thiadiazole derivatives: A new class of potent Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitors.	Jiangnan University
29878768	6	Total Syntheses of Lobaric Acid and Its Derivatives from the Antarctic Lichen Stereocaulon alpinum.	Korea Polar Research Institute
29289892	32	Discovery of novel high potent and cellular active ADC type PTP1B inhibitors with selectivity over TC-PTP via modification interacting with C site.	Qilu University of Technology
28511130	30	Design, synthesis and biological evaluation of uncharged catechol derivatives as selective inhibitors of PTP1B.	Chinese Academy of Sciences
29064696	18	Camellianols A-G, Barrigenol-like Triterpenoids with PTP1B Inhibitory Effects from the Endangered Ornamental Plant Camellia crapnelliana.	Fudan University
28834433	2	Meroterpenoids with Protein Tyrosine Phosphatase 1B Inhibitory Activity from a Hyrtios sp. Marine Sponge.	Shenyang Pharmaceutical University
29673715	4	Optimized allosteric inhibition of engineered protein tyrosine phosphatases with an expanded palette of biarsenical small molecules.	Amherst College
28642102	25	Varic acid analogues from fungus as PTP1B inhibitors: Biological evaluation and structure-activity relationships.	Dalian University of Technology
28624142	12	Anti-diabetic xanthones from the bark of Garcinia xanthochymus.	Vnuhcm-University of Science
28140583	10	Glycybridins A-K, Bioactive Phenolic Compounds from Glycyrrhiza glabra.	Peking University
28951079	5	PTP1B inhibitors from the seeds of Iris sanguinea and their insulin mimetic activities via AMPK and ACC phosphorylation.	Seoul National University
28389151	8	A bromopyrrole-containing diterpene alkaloid from the Okinawan marine sponge Agelas nakamurai activates the insulin pathway in Huh-7 human hepatoma cells by inhibiting protein tyrosine phosphatase 1B.	Tohoku Medical and Pharmaceutical University
28372909	45	Y-shaped bis-arylethenesulfonic acid esters: Potential potent and membrane permeable protein tyrosine phosphatase 1B inhibitors.	Shanghai Jiao Tong University
28318895	19	Competitive protein tyrosine phosphatase 1B (PTP1B) inhibitors, prenylated caged xanthones from Garcinia hanburyi and their inhibitory mechanism.	Gyeongsang National University
28579122	16	Design, synthesis, in silico and in vitro evaluation of thiophene derivatives: A potent tyrosine phosphatase 1B inhibitor and anticancer activity.	K L University
28522265	10	Screening for bioactive natural products from a 67-compound library of Glycyrrhiza inflata.	Peking University
29155585	9	Allosteric Inhibitors of SHP2 with Therapeutic Potential for Cancer Treatment.	Chinese Academy of Sciences
29116812	29	X-ray Characterization and Structure-Based Optimization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors.	Yale University
28454670	5	Structure-related protein tyrosine phosphatase 1B inhibition by naringenin derivatives.	Chonbuk National University
28395151	21	Discovery and evaluation of the hybrid of bromophenol and saccharide as potent and selective protein tyrosine phosphatase 1B inhibitors.	Chinese Academy of Sciences
22380772	34	Secondary/tertiary benzenesulfonamides with inhibitory action against the cytosolic human carbonic anhydrase isoforms I and II.	Ataturk University
25352216	105	A Molecular Dynamics Investigation of Mycobacterium tuberculosis Prenyl Synthases: Conformational Flexibility and Implications for Computer-aided Drug Discovery.	University of California San Diego
20209559	7	Structural investigation of the binding of 5-substituted swainsonine analogues to Golgi alpha-mannosidase II.	University of Toronto
20797617	8	Application of fragment-based drug discovery to membrane proteins: identification of ligands of the integral membrane enzyme DsbB.	Leiden University
19515558	120	Dipeptidyl nitrile inhibitors of Cathepsin L.	Astrazeneca