391 articles for thisTarget

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The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
27318552	126	Structural modifications of the serotonin 5-HT7 receptor agonist N-(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study.	Universit£
27364609	230	Development of CNS multi-receptor ligands: Modification of known D2 pharmacophores.	Florida A&M University
27312422	219	Design and synthesis of dual 5-HT1A and 5-HT7 receptor ligands.	Florida A&M University
27173799	97	Synthesis, structure-activity relationships, and biological evaluation of a series of benzamides as potential multireceptor antipsychotics.	Shanghai Institute Of Materia Medica
26954848	38	Discovery of 5-Chloro-1-(5-chloro-2-(methylsulfonyl)benzyl)-2-imino-1,2-dihydropyridine-3-carboxamide (TAK-259) as a Novel, Selective, and Orally Activea1D Adrenoceptor Antagonist with Antiurinary Frequency Effects: Reducing Human Ether-a-go-go-Related Gene (hERG) Liabilities.	Takeda Pharmaceutical
26876931	36	Optimization of N'-(arylsulfonyl)pyrazoline-1-carboxamidines by exploiting a novel interaction site in the 5-HT6 antagonistic binding pocket.	Abbott Healthcare Products
26988801	55	Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.	Jagiellonian University Medical College
26900658	56	Rational design in search for 5-phenylhydantoin selective 5-HT7R antagonists. Molecular modeling, synthesis and biological evaluation.	Jagiellonian University Medical College
26874044	56	Scouting new sigma receptor ligands: Synthesis, pharmacological evaluation and molecular modeling of 1,3-dioxolane-based structures and derivatives.	Universit£
26704965	229	Further Advances in Optimizing (2-Phenylcyclopropyl)methylamines as Novel Serotonin 2C Agonists: Effects on Hyperlocomotion, Prepulse Inhibition, and Cognition Models.	University Of Illinois At Chicago
26700945	68	Structure-Based Discovery of Novel and Selective 5-Hydroxytryptamine 2B Receptor Antagonists for the Treatment of Irritable Bowel Syndrome.	National Institute Of Biological Sciences, Beijing
26852005	82	Novel N-acyl-carbazole derivatives as 5-HT7R antagonists.	Yonsei University
26698537	93	Towards new 5-HT7 antagonists among arylsulfonamide derivatives of (aryloxy)ethyl-alkyl amines: Multiobjective based design, synthesis, and antidepressant and anxiolytic properties.	Jagiellonian University Medical College
26739781	237	Receptor binding profiles and quantitative structure-affinity relationships of some 5-substituted-N,N-diallyltryptamines.	The Alexander Shulgin Research Institute
26706111	72	N-Alkylated arylsulfonamides of (aryloxy)ethyl piperidines: 5-HT(7) receptor selectivity versus multireceptor profile.	Jagiellonian University Medical College
26271587	17	Discovery of selective N-[3-(1-methyl-piperidine-4-carbonyl)-phenyl]-benzamide-based 5-HT1 F receptor agonists: Evolution from bicyclic to monocyclic cores.	Eli Lilly
26227779	37	Discovery of novel potent and selective ligands for 5-HT2A receptor with quinazoline scaffold.	Fudan University
26203768	104	High Affinity Dopamine D3 Receptor (D3R)-Selective Antagonists Attenuate Heroin Self-Administration in Wild-Type but not D3R Knockout Mice.	National Institute On Drug Abuse-Intramural Research Program
25288493	96	Human alpha1-adrenoceptor subtype selectivity of substituted homobivalent 4-aminoquinolines.	Unsw Australia
25261823	107	Structure-affinity/activity relationships of 1,4-dioxa-spiro[4.5]decane based ligands ata<alpha>1 and 5-HT1A receptors.	Universit£
26081758	18	Arylpiperazine agonists of the serotonin 5-HT1A receptor preferentially activate cAMP signaling versus recruitment ofß-arrestin-2.	Karolinska Institute And Karolinska University Hospital
25695425	62	Semisynthetic Studies on and Biological Evaluation of N-Methyllaurotetanine Analogues as Ligands for 5-HT Receptors.	City University Of New York
25633969	96	Optimization of 2-phenylcyclopropylmethylamines as selective serotonin 2C receptor agonists and their evaluation as potential antipsychotic agents.	University Of Illinois At Chicago
25557493	109	Novel 5-HT6 receptor antagonists/D2 receptor partial agonists targeting behavioral and psychological symptoms of dementia.	Jagiellonian University Collegium Medicum
25555143	60	Towards novel 5-HT7versus 5-HT1A receptor ligands among LCAPs with cyclic amino acid amide fragments: design, synthesis, and antidepressant properties. Part II.	Jagiellonian University Medical College
25489882	63	Novel 2,4-disubstituted pyrimidines as potent, selective, and cell-permeable inhibitors of neuronal nitric oxide synthase.	Northwestern University
25866241	88	Fingerprint-based consensus virtual screening towards structurally new 5-HT(6)R ligands.	Jagiellonian University
25759032	55	Synthesis and binding properties of new long-chain 4-substituted piperazine derivatives as 5-HT1A and 5-HT7 receptor ligands.	Universit£
25128671	65	Structure-activity relationships and molecular modeling studies of novel arylpiperazinylalkyl 2-benzoxazolones and 2-benzothiazolones as 5-HT(7) and 5-HT(1A) receptor ligands.	Universit£
25127461	36	Novel N-biphenyl-2-ylmethyl 2-methoxyphenylpiperazinylalkanamides as 5-HT7R antagonists for the treatment of depression.	Yonsei University
25073094	24	The extracellular entrance provides selectivity to serotonin 5-HT7 receptor antagonists with antidepressant-like behavior in vivo.	Universidad Complutense De Madrid
25070422	126	Further evaluation of the tropane analogs of haloperidol.	Florida A&M University
25556097	70	Synthesis, pharmacological evaluation and molecular modeling studies of triazole containing dopamine D3 receptor ligands.	Washington University
25343529	221	Targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors for developing effective antipsychotics: synthesis, biological characterization, and behavioral studies.	Universit£
25308766	56	Design, synthesis and evaluation of benzo[a]thieno[3,2-g]quinolizines as novel l-SPD derivatives possessing dopamine D1, D2 and serotonin 5-HT1A multiple action profiles.	Chinese Academy Of Sciences
25241924	47	The design and implementation of a generic lipopeptide scanning platform to enable the identification of 'locally acting' agonists for the apelin receptor.	Novartis Institutes For Biomedical Research
25182564	38	Synthesis and evaluation of arylpiperazines derivatives of 3,5-dioxo-(2H,4H)-1,2,4-triazine as 5-HT1AR ligands.	Stony Brook University
24878222	50	Multiparameter optimization in CNS drug discovery: design of pyrimido[4,5-d]azepines as potent 5-hydroxytryptamine 2C (5-HT2C) receptor agonists with exquisite functional selectivity over 5-HT2A and 5-HT2B receptors.	Pfizer
24805037	380	Novel arylsulfonamide derivatives with 5-HT6/5-HT7 receptor antagonism targeting behavioral and psychological symptoms of dementia.	Adamed
24800940	146	Identification of a new selective dopamine D4 receptor ligand.	Florida A&M University
24900840	35	Enhancing a CH-? Interaction to Increase the Affinity for 5-HT1A Receptors.	University Of Li£Ge
24559051	141	Discovery of a tetracyclic quinoxaline derivative as a potent and orally active multifunctional drug candidate for the treatment of neuropsychiatric and neurological disorders.	Intra-Cellular Therapies
24691057	62	SAR-studies on the importance of aromatic ring topologies in search for selective 5-HT(7) receptor ligands among phenylpiperazine hydantoin derivatives.	Jagiellonian University Medical College
24675176	74	Solid-supported synthesis, molecular modeling, and biological activity of long-chain arylpiperazine derivatives with cyclic amino acid amide fragments as 5-HT(7) and 5-HT(1A) receptor ligands.	Jagiellonian University Medical College
23252794	56	Structure-activity relationships in 1,4-benzodioxan-related compounds. 11. (1) reversed enantioselectivity of 1,4-dioxane derivatives ina1-adrenergic and 5-HT1A receptor binding sites recognition.	University Of Camerino
16730983	165	Diaryl substituted pyrrolidinones and pyrrolones as 5-HT2C inhibitors: synthesis and biological evaluation.	Glaxosmithkline
23477943	51	Discovery of disubstituted piperidines and homopiperidines as potent dual NK1 receptor antagonists-serotonin reuptake transporter inhibitors for the treatment of depression.	Bristol-Myers Squibb
23332346	69	Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D(1), D(2) and serotonin 5-HT(1A) multi-action profile.	Chinese Academy Of Sciences
23425156	24	The discovery of novel potent trans-3,4-disubstituted pyrrolidine inhibitors of the human aspartic protease renin from in silico three-dimensional (3D) pharmacophore searches.	Novartis Pharma
23279866	69	Antidepressant and antipsychotic activity of new quinoline- and isoquinoline-sulfonamide analogs of aripiprazole targeting serotonin 5-HT1A/5-HT2A/5-HT7 and dopamine D2/D3 receptors.	Jagiellonian University Medical College
18162395	89	Ergoline derivatives as highly potent and selective antagonists at the somatostatin sst 1 receptor.	Novartis Institutes For Biomedical Research
12443779	44	2-(Dimethylaminomethyl)-tetrahydroisoxazolopyridobenzazepine derivatives. Synthesis of a new 5-HT(2C) antagonist with potential anxiolytic properties.	Janssen-Cilag
	18	Synthesis and serotonergic activity of benzofuran and dihydrogenzofuran analogues of 5-carboxamidotryptamine.	TBA
24900506	39	Low Doses of Allyphenyline and Cyclomethyline, Effective against Morphine Dependence, Elicit an Antidepressant-like Effect.	TBA
22370341	29	Favourable involvement ofa2A-adrenoreceptor antagonism in the I2-imidazoline binding sites-mediated morphine analgesia enhancement.	University Of Camerino
22145629	68	Synthesis, biological evaluation, and docking studies of tetrahydrofuran- cyclopentanone- and cyclopentanol-based ligands acting at adrenergica1- and serotonine 5-HT1A receptors.	Universit£
17562349	66	A chemometric study of the 5-HT(1A) receptor affinities presented by arylpiperazine compounds.	Universidade De S£O Paulo
20951584	105	5-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}-2(1H)-quinolinones and 3,4-dihydro-2(1H)-quinolinones: dual-acting 5-HT1 receptor antagonists and serotonin reuptake inhibitors. Part 3.	Glaxosmithkline
20801662	60	Structure-activity relationships in 1,4-benzodioxan-related compounds. 10. Novela1-adrenoreceptor antagonists related to openphendioxan: synthesis, biological evaluation, anda1d computational study.	Universit£
20605276	61	1,3-Dioxolane-based ligands incorporating a lactam or imide moiety: structure-affinity/activity relationship at alpha1-adrenoceptor subtypes and at 5-HT1A receptors.	Universit£
20133028	88	Pharmacophore-based 3D QSAR studies on a series of high affinity 5-HT1A receptor ligands.	Universidade Federal Da Para£Ba
20185311	72	Discovery of a new series of 5-HT1A receptor agonists.	Universit£
19846239	24	Application of desirability-based multi(bi)-objective optimization in the design of selective arylpiperazine derivates for the 5-HT1A serotonin receptor.	University Of Porto
19071020	66	Studies on a series of potent, orally bioavailable, 5-HT(1) receptor ligands--part II.	Glaxosmithkline
19286377	101	8-[2-(4-Aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones: dual-acting 5-HT1 receptor antagonists and serotonin reuptake inhibitors--part II.	Glaxosmithkline
18799312	84	6-[2-(4-Aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones: dual-acting 5-HT1 receptor antagonists and serotonin reuptake inhibitors.	Glaxosmithkline
18817363	84	Structure-activity relationships in 1,4-benzodioxan-related compounds. 9. From 1,4-benzodioxane to 1,4-dioxane ring as a promising template of novel alpha1D-adrenoreceptor antagonists, 5-HT1A full agonists, and cytotoxic agents.	Universit£
18829312	64	Novel 5-HT(1A/1B/1D) receptors antagonists with potent 5-HT reuptake inhibitory activity.	Glaxosmithkline
18433113	124	Discovery of potent, orally bioavailable, selective 5-HT1A/B/D receptor antagonists.	Glaxosmithkline
16039851	57	8-Piperazinyl-2,3-dihydropyrrolo[3,2-g]isoquinolines: potent, selective, orally bioavailable 5-HT1 receptor ligands.	Glaxosmithkline
9548813	53	The selective 5-HT1B receptor inverse agonist 1'-methyl-5-[[2'-methyl-4'-(5-methyl-1,2, 4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydro- spiro[furo[2,3-f]indole-3,4'-piperidine] (SB-224289) potently blocks terminal 5-HT autoreceptor function both in vitro and in vivo.	Smithkline Beecham Pharmaceuticals
9191957	210	Novel and selective partial agonists of 5-HT3 receptors. 2. Synthesis and biological evaluation of piperazinopyridopyrrolopyrazines, piperazinopyrroloquinoxalines, and piperazinopyridopyrroloquinoxalines.	Universit£
8642566	277	Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines.	Universit£
7752204	98	Synthesis and serotonergic activity of N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethylamine and analogues: potent agonists for 5-HT1D receptors.	Merck Sharp & Dohme Research Laboratories
8496922	92	Synthesis and serotonergic activity of 5-(oxadiazolyl)tryptamines: potent agonists for 5-HT1D receptors.	Merck Sharp And Dohme Research Laboratories
11755365	113	Synthesis and structure-activity relationship of 2-(aminoalkyl)-2,3,3a,8-tetrahydrodibenzo[c,f]isoxazolo[2,3-a]azepine derivatives: a novel series of 5-HT(2A/2C) receptor antagonists. Part 2.	Janssen-Cilag
11755364	104	Synthesis and structure-activity relationship of 2-(aminoalkyl)-2,3,3a,8-tetrahydrodibenzo[c,f]isoxazolo[2,3-a]azepine derivatives: a novel series of 5-HT(2A/2C) receptor antagonists. Part 1.	Janssen-Cilag
11229746	6	First tricyclic oximino derivatives as 5-HT3 ligands.	Universit£
11140733	92	Phenyl benzenesulfonamides are novel and selective 5-HT6 antagonists: identification of N-(2,5-dibromo-3-fluorophenyl)-4-methoxy-3-piperazin-1-ylbenzenesulfonamide (SB-357134).	Smithkline Beecham Pharmaceuticals
	68	The discovery of a series of new non-indole 5HT1D agonists	TBA
23043306	69	Systematic in vivo screening of a series of 1-propyl-4-arylpiperidines against dopaminergic and serotonergic properties in rat brain: a scaffold-jumping approach.	Neurosearch Sweden
22795332	66	Optimisation of imidazole compounds as selective TAAR1 agonists: discovery of RO5073012.	F. Hoffmann-La Roche
21486038	177	Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder.	H. Lundbeck
23102207	122	Synthesis and structure-affinity relationships of selective high-affinity 5-HT(4) receptor antagonists: application to the design of new potential single photon emission computed tomography tracers.	Universit£
23006002	35	Design, synthesis, and pharmacological evaluation of piperidin-4-yl amino aryl sulfonamides: novel, potent, selective, orally active, and brain penetrant 5-HT6 receptor antagonists.	Suven Life Sciences
22533875	11	Mitigating heterocycle metabolism in drug discovery.	Amgen
22845053	100	Structure-functional selectivity relationship studies ofß-arrestin-biased dopamine D2 receptor agonists.	University Of North Carolina At Chapel Hill
22738628	38	Moderate chemical modifications of WAY-100635 improve the selectivity for 5-HT1A versus D4 receptors.	University Of Li£Ge
22738316	35	Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin(7) (5-HT(7)) receptor with agonist or antagonist action in vitro or ex vivo.	Universit£
22694093	16	Life beyond kinases: structure-based discovery of sorafenib as nanomolar antagonist of 5-HT receptors.	National Institute Of Biological Sciences
22926225	200	The multiobjective based design, synthesis and evaluation of the arylsulfonamide/amide derivatives of aryloxyethyl- and arylthioethyl- piperidines and pyrrolidines as a novel class of potent 5-HT7 receptor antagonists.	TBA
24900202	38	Novel N-Substituted Benzimidazolones as Potent, Selective, CNS-Penetrant, and Orally Active M1 mAChR Agonists.	TBA
22748706	52	Design, synthesis, and pharmacological evaluation of novel tetrahydroprotoberberine derivatives: selective inhibitors of dopamine D1 receptor.	Shenyang Pharmaceutical University
22520153	135	Benzothiazoles as probes for the 5HT1A receptor and the serotonin transporter (SERT): a search for new dual-acting agents as potential antidepressants.	Florida A&M University
22607670	34	Interactions of N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-2-aryl-2-yl-acetamides and 1-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-3-aryl-2-yl-ureas with dopamine D2 and 5-hydroxytryptamine 5HT(1A) receptors.	University Of Belgrade
22542010	31	Discovery of a novel melanin concentrating hormone receptor 1 (MCHR1) antagonist with reduced hERG inhibition.	Amgen
22313242	146	2-(Pyrrolidin-1-yl)ethyl-3,4-dihydroisoquinolin-1(2H)-one derivatives as potent and selective histamine-3 receptor antagonists.	Pfizer
22313227	78	Radiosynthesis and evaluation of an (18)F-labeled positron emission tomography (PET) radioligand for brain histamine subtype-3 receptors based on a nonimidazole 2-aminoethylbenzofuran chemotype.	National Institute Of Mental Health
22268448	34	New pyridobenzoxazepine derivatives derived from 5-(4-methylpiperazin-1-yl)-8-chloro-pyrido[2,3-b][1,5]benzoxazepine (JL13): chemical synthesis and pharmacological evaluation.	University Of Li£Ge
21859078	62	Combination of two pharmacophoric systems: synthesis and pharmacological evaluation of spirocyclic pyranopyrazoles with highs1 receptor affinity.	Institut F£R Pharmazeutische Und Medizinische Chemie Der Universit£T M£Nster
21726069	98	Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators.	University Of Namur
21207959	69	Syntheses of 2-amino and 2-halothiazole derivatives as high-affinity metabotropic glutamate receptor subtype 5 ligands and potential radioligands for in vivo imaging.	National Institute Of Mental Health
20931963	112	Discovery of a novel 5-HT(3) antagonist/5-HT(1A) agonist 3-amino-5,6,7,8-tetrahydro-2-{4-[4-(quinolin-2-yl)piperazin-1-yl]butyl}quinazolin-4(3H)-one (TZB-30878) as an orally bioavailable agent for irritable bowel syndrome.	Aska Pharmaceutical
20684563	176	Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 receptor agonist with unprecedented selectivity and procognitive potential.	H. Lundbeck
20041669	85	Synthesis of dihydrofuroaporphine derivatives: identification of a potent and selective serotonin 5-HT 1A receptor agonist.	Chinese Academy Of Sciences
20153652	49	Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors.	Universidade Federal Do Rio Grande Do Sul
19754201	2	Physical binding pocket induction for affinity prediction.	University Of California
19705871	14	Synthesis and characterization of environment-sensitive fluorescent ligands for human 5-HT1A receptors with 1-arylpiperazine structure.	Universita Degli Studi Di Bari
19559623	33	'Click' D(1) receptor agonists with a 5-HT(1A) receptor pharmacophore producing D(2) receptor activity.	Chinese Academy Of Sciences
19331412	122	N-(4-(4-(2,3-dichloro- or 2-methoxyphenyl)piperazin-1-yl)butyl)heterobiarylcarboxamides with functionalized linking chains as high affinity and enantioselective D3 receptor antagonists.	National Institute On Drug Abuse-Intramural Research Program
19159187	38	Indene-based scaffolds. 2. An indole-indene switch: discovery of novel indenylsulfonamides as 5-HT6 serotonin receptor agonists.	Universitat De Barcelona
18834188	232	Advances toward new antidepressants with dual serotonin transporter and 5-HT1A receptor affinity within a class of 3-aminochroman derivatives. Part 2.	Wyeth Research
16562853	22	Alkaloids from Eschscholzia californica and their capacity to inhibit binding of [3H]8-Hydroxy-2-(di-N-propylamino)tetralin to 5-HT1A receptors in Vitro.	Tom'S Of Maine
18468904	48	High specific activity tritium-labeled N-(2-methoxybenzyl)-2,5-dimethoxy-4-iodophenethylamine (INBMeO): a high-affinity 5-HT2A receptor-selective agonist radioligand.	Purdue University
18083580	118	Novel quinazolinone derivatives as 5-HT7 receptor ligands.	Institute Of Science And Technology
18221879	13	Synthesis and structure-affinity relationships of novel spirocyclic sigma receptor ligands with furopyrazole structure.	Westf£Lische Wilhelms-Universit£T M£Nster
18269229	16	N-[omega-[4-(2-methoxyphenyl)-1-piperazinyl]alkyl]-2-quinolinamines as high-affinity fluorescent 5-HT1A receptor ligands.	Universita Degli Studi Di Bari
17483457	58	A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.	Abbott Laboratories
18029187	20	Synthesis and structure-activity relationships of N-(3-phenylpropyl)-N'-benzylpiperazines: Potent ligands for sigma1 and sigma2 receptors.	University Of Missouri-Columbia
18023344	77	Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: optimising brain penetration.	F. Hoffmann-La Roche
17998160	101	Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation.	F. Hoffmann-La Roche
18181565	71	Multi-target-directed ligands to combat neurodegenerative diseases.	University Of Bologna
16854086	96	Synthesis and biological evaluation of novel compounds within a class of 3-aminochroman derivatives with dual 5-HT1A receptor and serotonin transporter affinity.	Wyeth Research
16789750	155	2-[(4-phenylpiperazin-1-yl)methyl]imidazo(di)azines as selective D4-ligands. Induction of penile erection by 2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]imidazo[1,2-a]pyridine (PIP3EA), a potent and selective D4 partial agonist.	Laboratoire De Chimie Th�Rapeutique
16480278	279	1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors.	Organix
16198561	99	Novel CCR1 antagonists with oral activity in the mouse collagen induced arthritis.	Novartis Institutes For Biomedical Research
16220969	219	Designed multiple ligands. An emerging drug discovery paradigm.	Organon Laboratories
15658848	103	Discovery of 5-arylsulfonamido-3-(pyrrolidin-2-ylmethyl)-1H-indole derivatives as potent, selective 5-HT6 receptor agonists and antagonists.	Wyeth Research
15916420	68	Fancy bioisosteres: metallocene-derived G-protein-coupled receptor ligands with subnanomolar binding affinity and novel selectivity profiles.	Friedrich-Alexander University
15887953	16	Synthesis and biological evaluation of benzodioxanylpiperazine derivatives as potent serotonin 5-HT(1A) antagonists: the discovery of Lecozotan.	Wyeth Research
15634021	113	Synthesis and structure-activity relationships of 1-aralkyl-4-benzylpiperidine and 1-aralkyl-4-benzylpiperazine derivatives as potent sigma ligands.	Universit£
15357957	29	Synthesis, receptor binding and functional studies of mesoridazine stereoisomers.	Brigham & Women'S Hospital
15239663	60	Discovery of 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a dopaminergic agent with a novel mode of action for the potential treatment of erectile dysfunction.	Abbott Laboratories
12519065	243	Synthesis and structure-affinity relationship investigations of 5-heteroaryl-substituted analogues of the antipsychotic sertindole. A new class of highly selective alpha(1) adrenoceptor antagonists.	H. Lundbeck
12954071	109	A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole.	Alcon Research
12825922	207	Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).	Virginia Commonwealth University
12361386	113	Interactive SAR studies: rational discovery of super-potent and highly selective dopamine D3 receptor antagonists and partial agonists.	Friedrich-Alexander University
12213075	70	Lysergamides of isomeric 2,4-dimethylazetidines map the binding orientation of the diethylamide moiety in the potent hallucinogenic agent N,N-diethyllysergamide (LSD).	Purdue University
11170639	73	Current and novel approaches to the drug treatment of schizophrenia.	Merck Sharp And Dohme Research Laboratories
11708905	20	N-[3-(2-Dimethylaminoethyl)-2-methyl-1H- indol-5-yl]-4-fluorobenzamide: a potent, selective, and orally active 5-HT(1F) receptor agonist potentially useful for migraine therapy.	Eli Lilly
11585444	295	From hit to lead. Analyzing structure-profile relationships.	Universities Of Lille
10602703	73	A series of 6- and 7-piperazinyl- and -piperidinylmethylbenzoxazinones with dopamine D4 antagonist activity: discovery of a potential atypical antipsychotic agent.	Warner-Lambert
9083484	84	New benzocycloalkylpiperazines, potent and selective 5-HT1A receptor ligands.	Cooperation Pharmaceutique Fran�Aise
8568804	42	New sigma and 5-HT1A receptor ligands: omega-(tetralin-1-yl)-n-alkylamine derivatives.	Universit£
7562938	17	New antihistamines: substituted piperazine and piperidine derivatives as novel H1-antagonists.	Wyeth-Ayerst Research
7658447	72	Synthesis and serotonergic activity of arylpiperazide derivatives of serotonin: potent agonists for 5-HT1D receptors.	Centre De Recherche Pierre Fabre
7608898	4	The serotonin 5-HT4 receptor. 1. Design of a new class of agonists and receptor map of the agonist recognition site.	Sandoz Pharma
8097538	69	Centrally acting serotonergic and dopaminergic agents. 2. Synthesis and structure-activity relationships of 2,3,3a,4,9,9a-hexahydro-1H-benz[f]indole derivatives.	Upjohn Laboratories
8101876	28	Novel 2-substituted tetrahydro-3H-benz[e]indolamines: highly potent and selective agonists acting at the 5-HT1A receptor as possible anxiolytics and antidepressants.	Upjohn Laboratories
8496900	136	Comparison of 5-HT1A and dopamine D2 pharmacophores. X-ray structures and affinities of conformationally constrained ligands.	Upjohn Laboratories
1348089	71	Dopaminergic and serotonergic activities of imidazoquinolinones and related compounds.	Upjohn Laboratories
15203136	39	(+/-)8-Amino-5,6,7,8-tetrahydroisoquinolines as novel antinociceptive agents.	Virginia Commonwealth University
11844688	102	Di- and trisubstituted pyrazolo[1,5-a]pyridine derivatives: synthesis, dopamine receptor binding and ligand efficacy.	Friedrich-Alexander University
12113813	53	2,4-Disubstituted pyrroles: synthesis, traceless linking and pharmacological investigations leading to the dopamine D4 receptor partial agonist FAUC 356.	Friedrich-Alexander University
11549463	72	Benzamide bioisosteres incorporating dihydroheteroazole substructures: EPC synthesis and SAR leading to a selective dopamine D4 receptor partial agonist (FAUC 179).	Friedrich-Alexander University
10576696	32	Parallel synthesis of 3-aryloxy-2-propanolamines and evaluation as dual affinity 5-HT(1A) and 5-HT re-uptake ligands.	Merck
	25	Pyrazolo[1,5-a]pyridines and pyrazolo[1,5-b]pyridazines as 5ht3-antagonists	TBA
22336245	72	Structure-activity relationship studies of SYA 013, a homopiperazine analog of haloperidol.	Florida A&M University
22309909	37	Synthesis, in vitro binding studies and docking of long-chain arylpiperazine nitroquipazine analogues, as potential serotonin transporter inhibitors.	National Medicines Institute
22245230	128	Multi-receptor drug design: Haloperidol as a scaffold for the design and synthesis of atypical antipsychotic agents.	Florida A&M University
22029386	156	New serotonin 5-HT(1A) receptor agonists with neuroprotective effect against ischemic cell damage.	Universidad Complutense De Madrid
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15239661	120	Studies toward the discovery of the next generation of antidepressants. 3. Dual 5-HT1A and serotonin transporter affinity within a class of N-aryloxyethylindolylalkylamines.	Wyeth Research
15225707	42	Synthesis and radioiodination of selective ligands for the dopamine D3 receptor subtype.	University Of Erlangen-Nuremberg
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14643338	124	Binding of beta-carbolines at 5-HT(2) serotonin receptors.	Virginia Commonwealth University
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12824042	64	Advances Toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT(1A) receptor antagonism/SSRI activities. Part 2.	Eli Lilly
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12161137	39	Fused azaindole derivatives: molecular design, synthesis and in vitro pharmacology leading to the preferential dopamine D3 receptor agonist FAUC 725.	Friedrich-Alexander University
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11728188	53	trans-4-[4-(Methoxyphenyl)cyclohexyl]-1-arylpiperazines: a new class of potent and selective 5-HT(1A) receptor ligands as conformationally constrained analogues of 4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]-1-arylpiperazines.	Università
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11311055	42	Atropisomeric derivatives of 2',6'-disubstituted (R)-11-phenylaporphine: selective serotonin 5-HT(7) receptor antagonists.	Uppsala University
11277522	7	A novel fluorinated tryptamine with highly potent serotonin 5-HT1A receptor agonist properties.	Purdue University
11212112	24	Serotonergic and dopaminergic activities of rigidified (R)-aporphine derivatives.	Uppsala University
11101361	37	Effect of ring fluorination on the pharmacology of hallucinogenic tryptamines.	Purdue University
11055342	21	N1-(Benzenesulfonyl)tryptamines as novel 5-HT6 antagonists.	Virginia Commonwealth University
10841797	110	Design, synthesis, and structure-activity relationships of phthalimide-phenylpiperazines: a novel series of potent and selective alpha(1)(a)-adrenergic receptor antagonists.	The R. W. Johnson Pharmaceutical Research Institute
10753471	64	Derivatives of (R)-1,11-methyleneaporphine: synthesis, structure, and interactions with G-protein coupled receptors.	Uppsala University
10715164	57	2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors.	Virginia Commonwealth University
10585208	212	3-[3-(Piperidin-1-yl)propyl]indoles as highly selective h5-HT(1D) receptor agonists.	Merck Sharp & Dohme Research Laboratories
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10052975	129	Synthesis and serotonergic activity of 3-[2-(pyrrolidin-1-yl)ethyl]indoles: potent agonists for the h5-HT1D receptor with high selectivity over the h5-HT1B receptor.	Merck Sharp And Dohme Research Laboratories
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9873746	13	Design and synthesis of new potent, silent 5-HT1A antagonists by covalent coupling of aminopropanol derivatives with selective serotonin reuptake inhibitors.	Centre De Recherche Pierre Fabre
9871775	29	Dimers of 5HT1 ligands preferentially bind to 5HT1B/1D receptor subtypes.	Centre De Recherche Pierre Fabre
9871581	12	Dimerization of sumatriptan as an efficient way to design a potent, centrally and orally active 5-HT1B agonist.	Centre De Recherche Pierre Fabre
9857099	94	Design and synthesis of novel alpha1a adrenoceptor-selective dihydropyridine antagonists for the treatment of benign prostatic hyperplasia.	Synaptic Pharmaceutical
9632349	38	Isochroman-6-carboxamides as highly selective 5-HT1D agonists: potential new treatment for migraine without cardiovascular side effects.	Pharmacia & Upjohn
9622542	119	Novel benzothiazolin-2-one and benzoxazin-3-one arylpiperazine derivatives with mixed 5HT1A/D2 affinity as potential atypical antipsychotics.	Institut De Chimie Pharmaceutique Albert Lespagnol
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9057850	27	Synthesis and biological activities of (R)-5,6-dihydro-N,N-dimethyl-4H-imidazo[4,5,1-ij]quinolin-5-amine and its metabolites.	Pharmacia & Upjohn
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8960551	74	Serotonin dimers: application of the bivalent ligand approach to the design of new potent and selective 5-HT(1B/1D) agonists.	Centre De Recherche Pierre Fabre
8941384	51	5-HT1D receptor agonist properties of novel 2-[5-[[(trifluoromethyl)sulfonyl]oxy]indolyl]ethylamines and their use as synthetic intermediates.	University Of Groningen
8568822	80	Binding of O-alkyl derivatives of serotonin at human 5-HT1D beta receptors.	Virginia Commonwealth University
8459396	37	Centrally acting serotonergic agents. Synthesis and structure-activity relationships of C-1- or C-3-substituted derivatives of 8-hydroxy-2-(di-n-propylamino)tetralin.	Upjohn Laboratories
8340922	7	Synthesis and biological activity of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro- 3-propyl-1H-benz[e]indole-9-carboxamide: a potent and selective 5-HT1A receptor agonist with good oral availability.	Upjohn Laboratories
8097537	91	Centrally acting serotonergic and dopaminergic agents. 1. Synthesis and structure-activity relationships of 2,3,3a,4,5,9b-hexahydro-1H-benz[e]indole derivatives.	Upjohn Laboratories
8071931	20	5-(Nonyloxy)tryptamine: a novel high-affinity 5-HT1D beta serotonin receptor agonist.	Medical College Of Virginia/Virginia Commonwealth University
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