Compile Data Set for Download or QSAR

Found 66 hits with Last Name = 'edgerton' and Initial = 'jr'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50240692 (CHEMBL4078588) Show SMILES Cc1ccc(Cc2cc3c(ncn([C@H]4CCCC[C@@H]4O)c3=O)c3ccccc23)cn1 |r| Show InChI InChI=1S/C25H25N3O2/c1-16-10-11-17(14-26-16)12-18-13-21-24(20-7-3-2-6-19(18)20)27-15-28(25(21)30)22-8-4-5-9-23(22)29/h2-3,6-7,10-11,13-15,22-23,29H,4-5,8-9,12H2,1H3/t22-,23-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem	Article PubMed	8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Displacement of [3H]PT-1284 human muscarinic acetylcholine receptor M1 expressed in CHO cell membranes after 90 mins scintillation counting method				J Med Chem 60: 6649-6663 (2017) Article DOI: 10.1021/acs.jmedchem.7b00597 BindingDB Entry DOI: 10.7270/Q2ZK5JS0
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50240694 (CHEMBL4067722) Show SMILES Cc1cc2CN([C@H]3CCOC[C@@H]3O)C(=O)c2cc1Cc1ccc(cc1)-c1cocn1 |r| Show InChI InChI=1S/C24H24N2O4/c1-15-8-19-11-26(22-6-7-29-13-23(22)27)24(28)20(19)10-18(15)9-16-2-4-17(5-3-16)21-12-30-14-25-21/h2-5,8,10,12,14,22-23,27H,6-7,9,11,13H2,1H3/t22-,23-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Displacement of [3H]PT-1284 human muscarinic acetylcholine receptor M1 expressed in CHO cell membranes after 90 mins scintillation counting method				J Med Chem 60: 6649-6663 (2017) Article DOI: 10.1021/acs.jmedchem.7b00597 BindingDB Entry DOI: 10.7270/Q2ZK5JS0
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50240693 (CHEMBL4097569) Show SMILES Cc1cnc(cc1Cc1ccc(cc1)-c1cscn1)C(=O)N[C@H]1CCOC[C@@H]1O |r| Show InChI InChI=1S/C22H23N3O3S/c1-14-10-23-19(22(27)25-18-6-7-28-11-21(18)26)9-17(14)8-15-2-4-16(5-3-15)20-12-29-13-24-20/h2-5,9-10,12-13,18,21,26H,6-8,11H2,1H3,(H,25,27)/t18-,21-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	19	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Displacement of [3H]PT-1284 human muscarinic acetylcholine receptor M1 expressed in CHO cell membranes after 90 mins scintillation counting method				J Med Chem 60: 6649-6663 (2017) Article DOI: 10.1021/acs.jmedchem.7b00597 BindingDB Entry DOI: 10.7270/Q2ZK5JS0
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50135213 (CHEMBL3747016) Show SMILES Cn1ccc(n1)-c1ccc(Cn2cc(C(=O)N[C@H]3CCOC[C@@H]3O)c3ncccc23)cc1 |r| Show InChI InChI=1S/C24H25N5O3/c1-28-11-8-19(27-28)17-6-4-16(5-7-17)13-29-14-18(23-21(29)3-2-10-25-23)24(31)26-20-9-12-32-15-22(20)30/h2-8,10-11,14,20,22,30H,9,12-13,15H2,1H3,(H,26,31)/t20-,22-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description In vitro inhibitory activity against [3H]- (+)-3-PPP binding to Sigma opioid receptor in guinea pig brain membrane homogenates				J Med Chem 60: 6649-6663 (2017) Article DOI: 10.1021/acs.jmedchem.7b00597 BindingDB Entry DOI: 10.7270/Q2ZK5JS0
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50240693 (CHEMBL4097569) Show SMILES Cc1cnc(cc1Cc1ccc(cc1)-c1cscn1)C(=O)N[C@H]1CCOC[C@@H]1O |r| Show InChI InChI=1S/C22H23N3O3S/c1-14-10-23-19(22(27)25-18-6-7-28-11-21(18)26)9-17(14)8-15-2-4-16(5-3-15)20-12-29-13-24-20/h2-5,9-10,12-13,18,21,26H,6-8,11H2,1H3,(H,25,27)/t18-,21-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.09E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of PDE2A (unknown origin)				Citation and Details Article DOI: 10.1021/acs.jmedchem.6b00544 BindingDB Entry DOI: 10.7270/Q2MC93Q2
					More data for this Ligand-Target Pair
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (Homo sapiens (Human))	BDBM50240693 (CHEMBL4097569) Show SMILES Cc1cnc(cc1Cc1ccc(cc1)-c1cscn1)C(=O)N[C@H]1CCOC[C@@H]1O |r| Show InChI InChI=1S/C22H23N3O3S/c1-14-10-23-19(22(27)25-18-6-7-28-11-21(18)26)9-17(14)8-15-2-4-16(5-3-15)20-12-29-13-24-20/h2-5,9-10,12-13,18,21,26H,6-8,11H2,1H3,(H,25,27)/t18-,21-/m0/s1	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.94E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of PDE11A4 (unknown origin)				Citation and Details Article DOI: 10.1021/acs.jmedchem.6b00544 BindingDB Entry DOI: 10.7270/Q2MC93Q2
					More data for this Ligand-Target Pair
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (Homo sapiens (Human))	BDBM50240694 (CHEMBL4067722) Show SMILES Cc1cc2CN([C@H]3CCOC[C@@H]3O)C(=O)c2cc1Cc1ccc(cc1)-c1cocn1 |r| Show InChI InChI=1S/C24H24N2O4/c1-15-8-19-11-26(22-6-7-29-13-23(22)27)24(28)20(19)10-18(15)9-16-2-4-17(5-3-16)21-12-30-14-25-21/h2-5,8,10,12,14,22-23,27H,6-7,9,11,13H2,1H3/t22-,23-/m0/s1	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.06E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of PDE11A4 (unknown origin)				J Med Chem 60: 6649-6663 (2017) Article DOI: 10.1021/acs.jmedchem.7b00597 BindingDB Entry DOI: 10.7270/Q2ZK5JS0
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50135188 (CHEMBL3746377) Show SMILES Cn1ccc(n1)-c1ccc(Cn2cc(C(=O)N[C@H]3CCCC[C@@H]3O)c3ncccc23)cc1 |r| Show InChI InChI=1S/C25H27N5O2/c1-29-14-12-20(28-29)18-10-8-17(9-11-18)15-30-16-19(24-22(30)6-4-13-26-24)25(32)27-21-5-2-3-7-23(21)31/h4,6,8-14,16,21,23,31H,2-3,5,7,15H2,1H3,(H,27,32)/t21-,23-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	89	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 26: 650-5 (2016) Article DOI: 10.1016/j.bmcl.2015.11.053 BindingDB Entry DOI: 10.7270/Q29C708F
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50135190 (CHEMBL3745973) Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)c1cn(Cc2ccc(cc2)-n2cccn2)c2cccnc12 |r| Show InChI InChI=1S/C24H25N5O2/c30-22-7-2-1-5-20(22)27-24(31)19-16-28(21-6-3-12-25-23(19)21)15-17-8-10-18(11-9-17)29-14-4-13-26-29/h3-4,6,8-14,16,20,22,30H,1-2,5,7,15H2,(H,27,31)/t20-,22-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	101	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 26: 650-5 (2016) Article DOI: 10.1016/j.bmcl.2015.11.053 BindingDB Entry DOI: 10.7270/Q29C708F
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50135191 (CHEMBL3746904) Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)c1cn(Cc2ccc3ncccc3c2)c2cccnc12 |r| Show InChI InChI=1S/C24H24N4O2/c29-22-8-2-1-6-20(22)27-24(30)18-15-28(21-7-4-12-26-23(18)21)14-16-9-10-19-17(13-16)5-3-11-25-19/h3-5,7,9-13,15,20,22,29H,1-2,6,8,14H2,(H,27,30)/t20-,22-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	185	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 26: 650-5 (2016) Article DOI: 10.1016/j.bmcl.2015.11.053 BindingDB Entry DOI: 10.7270/Q29C708F
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50135192 (CHEMBL3747037) Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)c1cn(Cc2ccc(cc2)-n2cc(cn2)-c2ccncc2)c2cccnc12 |r| Show InChI InChI=1S/C29H28N6O2/c36-27-6-2-1-4-25(27)33-29(37)24-19-34(26-5-3-13-31-28(24)26)17-20-7-9-23(10-8-20)35-18-22(16-32-35)21-11-14-30-15-12-21/h3,5,7-16,18-19,25,27,36H,1-2,4,6,17H2,(H,33,37)/t25-,27-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	273	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 26: 650-5 (2016) Article DOI: 10.1016/j.bmcl.2015.11.053 BindingDB Entry DOI: 10.7270/Q29C708F
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50135194 (CHEMBL3745962) Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)c1cn(Cc2ccc(cc2)-c2cncnc2)c2cccnc12 |r| Show InChI InChI=1S/C25H25N5O2/c31-23-6-2-1-4-21(23)29-25(32)20-15-30(22-5-3-11-28-24(20)22)14-17-7-9-18(10-8-17)19-12-26-16-27-13-19/h3,5,7-13,15-16,21,23,31H,1-2,4,6,14H2,(H,29,32)/t21-,23-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	371	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 26: 650-5 (2016) Article DOI: 10.1016/j.bmcl.2015.11.053 BindingDB Entry DOI: 10.7270/Q29C708F
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50135196 (CHEMBL3745995) Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)c1cn(Cc2ccc(cc2)C#N)c2cccnc12 |r| Show InChI InChI=1S/C22H22N4O2/c23-12-15-7-9-16(10-8-15)13-26-14-17(21-19(26)5-3-11-24-21)22(28)25-18-4-1-2-6-20(18)27/h3,5,7-11,14,18,20,27H,1-2,4,6,13H2,(H,25,28)/t18-,20-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	478	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 26: 650-5 (2016) Article DOI: 10.1016/j.bmcl.2015.11.053 BindingDB Entry DOI: 10.7270/Q29C708F
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50135199 (CHEMBL3747166) Show SMILES O[C@H]1COCC[C@@H]1NC(=O)c1cn(Cc2ccc(cc2)-n2cccn2)c2cccnc12 |r| Show InChI InChI=1S/C23H23N5O3/c29-21-15-31-12-8-19(21)26-23(30)18-14-27(20-3-1-9-24-22(18)20)13-16-4-6-17(7-5-16)28-11-2-10-25-28/h1-7,9-11,14,19,21,29H,8,12-13,15H2,(H,26,30)/t19-,21-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	63	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 26: 650-5 (2016) Article DOI: 10.1016/j.bmcl.2015.11.053 BindingDB Entry DOI: 10.7270/Q29C708F
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50135200 (CHEMBL3746514) Show SMILES CN(C)C(=O)CNC(=O)c1cn(Cc2ccc(cc2)-n2cccn2)c2cccnc12 Show InChI InChI=1S/C22H22N6O2/c1-26(2)20(29)13-24-22(30)18-15-27(19-5-3-10-23-21(18)19)14-16-6-8-17(9-7-16)28-12-4-11-25-28/h3-12,15H,13-14H2,1-2H3,(H,24,30)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	112	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 26: 650-5 (2016) Article DOI: 10.1016/j.bmcl.2015.11.053 BindingDB Entry DOI: 10.7270/Q29C708F
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50135204 (CHEMBL3747254) Show SMILES O=C(NC[C@@H]1CCCO1)c1cn(Cc2ccc(cc2)-n2cccn2)c2cccnc12 |r| Show InChI InChI=1S/C23H23N5O2/c29-23(25-14-19-4-2-13-30-19)20-16-27(21-5-1-10-24-22(20)21)15-17-6-8-18(9-7-17)28-12-3-11-26-28/h1,3,5-12,16,19H,2,4,13-15H2,(H,25,29)/t19-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	175	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 26: 650-5 (2016) Article DOI: 10.1016/j.bmcl.2015.11.053 BindingDB Entry DOI: 10.7270/Q29C708F
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50135205 (CHEMBL3745855) Show SMILES OC[C@H]1CC[C@@H](CC1)NC(=O)c1cn(Cc2ccc(cc2)-n2cccn2)c2cccnc12 |r,wU:5.8,wD:2.1,(6.87,9.12,;5.66,8.87,;5.18,7.41,;3.68,7.09,;3.2,5.62,;4.23,4.48,;5.73,4.8,;6.21,6.26,;3.75,3.01,;2.24,2.7,;1.42,3.61,;1.76,1.24,;2.66,.02,;1.76,-1.24,;2.24,-2.7,;3.75,-3.01,;4.24,-4.47,;5.75,-4.78,;6.77,-3.63,;6.28,-2.16,;4.77,-1.86,;8.28,-3.93,;8.9,-5.33,;10.43,-5.16,;10.73,-3.65,;9.39,-2.89,;.3,-.77,;-1.03,-1.55,;-2.38,-.77,;-2.38,.77,;-1.03,1.55,;.3,.77,)| Show InChI InChI=1S/C25H27N5O2/c31-17-19-4-8-20(9-5-19)28-25(32)22-16-29(23-3-1-12-26-24(22)23)15-18-6-10-21(11-7-18)30-14-2-13-27-30/h1-3,6-7,10-14,16,19-20,31H,4-5,8-9,15,17H2,(H,28,32)/t19-,20-	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	248	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 26: 650-5 (2016) Article DOI: 10.1016/j.bmcl.2015.11.053 BindingDB Entry DOI: 10.7270/Q29C708F
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50135206 (CHEMBL3747724) Show SMILES Cn1ccc(NC(=O)c2cn(Cc3ccc(cc3)-n3cccn3)c3cccnc23)n1 Show InChI InChI=1S/C22H19N7O/c1-27-13-9-20(26-27)25-22(30)18-15-28(19-4-2-10-23-21(18)19)14-16-5-7-17(8-6-16)29-12-3-11-24-29/h2-13,15H,14H2,1H3,(H,25,26,30)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	258	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 26: 650-5 (2016) Article DOI: 10.1016/j.bmcl.2015.11.053 BindingDB Entry DOI: 10.7270/Q29C708F
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50135207 (CHEMBL3747287) Show SMILES OC1(CNC(=O)c2cn(Cc3ccc(cc3)-n3cccn3)c3cccnc23)CCC1 Show InChI InChI=1S/C23H23N5O2/c29-22(25-16-23(30)9-2-10-23)19-15-27(20-4-1-11-24-21(19)20)14-17-5-7-18(8-6-17)28-13-3-12-26-28/h1,3-8,11-13,15,30H,2,9-10,14,16H2,(H,25,29)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	500	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 26: 650-5 (2016) Article DOI: 10.1016/j.bmcl.2015.11.053 BindingDB Entry DOI: 10.7270/Q29C708F
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50135208 (CHEMBL3746599) Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)c1cn(Cc2ccc(cc2)-n2cccn2)c2ccccc12 |r| Show InChI InChI=1S/C25H26N4O2/c30-24-9-4-2-7-22(24)27-25(31)21-17-28(23-8-3-1-6-20(21)23)16-18-10-12-19(13-11-18)29-15-5-14-26-29/h1,3,5-6,8,10-15,17,22,24,30H,2,4,7,9,16H2,(H,27,31)/t22-,24-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	163	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 26: 650-5 (2016) Article DOI: 10.1016/j.bmcl.2015.11.053 BindingDB Entry DOI: 10.7270/Q29C708F
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50135209 (CHEMBL3746322) Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)c1nn(Cc2ccc(cc2)-n2cccn2)c2ccccc12 |r| Show InChI InChI=1S/C24H25N5O2/c30-22-9-4-2-7-20(22)26-24(31)23-19-6-1-3-8-21(19)29(27-23)16-17-10-12-18(13-11-17)28-15-5-14-25-28/h1,3,5-6,8,10-15,20,22,30H,2,4,7,9,16H2,(H,26,31)/t20-,22-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	4.50E+3	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 26: 650-5 (2016) Article DOI: 10.1016/j.bmcl.2015.11.053 BindingDB Entry DOI: 10.7270/Q29C708F
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50135210 (CHEMBL3746104) Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)c1nn(Cc2ccc(cc2)-n2cccn2)c2cccnc12 |r| Show InChI InChI=1S/C23H24N6O2/c30-20-7-2-1-5-18(20)26-23(31)22-21-19(6-3-12-24-21)29(27-22)15-16-8-10-17(11-9-16)28-14-4-13-25-28/h3-4,6,8-14,18,20,30H,1-2,5,7,15H2,(H,26,31)/t18-,20-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	215	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 26: 650-5 (2016) Article DOI: 10.1016/j.bmcl.2015.11.053 BindingDB Entry DOI: 10.7270/Q29C708F
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50135213 (CHEMBL3747016) Show SMILES Cn1ccc(n1)-c1ccc(Cn2cc(C(=O)N[C@H]3CCOC[C@@H]3O)c3ncccc23)cc1 |r| Show InChI InChI=1S/C24H25N5O3/c1-28-11-8-19(27-28)17-6-4-16(5-7-17)13-29-14-18(23-21(29)3-2-10-25-23)24(31)26-20-9-12-32-15-22(20)30/h2-8,10-11,14,20,22,30H,9,12-13,15H2,1H3,(H,26,31)/t20-,22-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	55	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 26: 650-5 (2016) Article DOI: 10.1016/j.bmcl.2015.11.053 BindingDB Entry DOI: 10.7270/Q29C708F
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50135215 (CHEMBL3745724) Show SMILES Cc1ccc2n(Cc3ccc(cc3)-c3ccn(C)n3)cc(C(=O)N[C@H]3CCOC[C@@H]3O)c2n1 |r| Show InChI InChI=1S/C25H27N5O3/c1-16-3-8-22-24(26-16)19(25(32)27-21-10-12-33-15-23(21)31)14-30(22)13-17-4-6-18(7-5-17)20-9-11-29(2)28-20/h3-9,11,14,21,23,31H,10,12-13,15H2,1-2H3,(H,27,32)/t21-,23-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	293	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 26: 650-5 (2016) Article DOI: 10.1016/j.bmcl.2015.11.053 BindingDB Entry DOI: 10.7270/Q29C708F
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50135216 (CHEMBL3747004) Show SMILES Cc1cnc2c(cn(Cc3ccc(cc3)-c3ccn(C)n3)c2c1)C(=O)N[C@H]1CCOC[C@@H]1O |r| Show InChI InChI=1S/C25H27N5O3/c1-16-11-22-24(26-12-16)19(25(32)27-21-8-10-33-15-23(21)31)14-30(22)13-17-3-5-18(6-4-17)20-7-9-29(2)28-20/h3-7,9,11-12,14,21,23,31H,8,10,13,15H2,1-2H3,(H,27,32)/t21-,23-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	211	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 26: 650-5 (2016) Article DOI: 10.1016/j.bmcl.2015.11.053 BindingDB Entry DOI: 10.7270/Q29C708F
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50135217 (CHEMBL3746869) Show SMILES Cc1ccnc2c(cn(Cc3ccc(cc3)-c3ccn(C)n3)c12)C(=O)N[C@H]1CCOC[C@@H]1O |r| Show InChI InChI=1S/C25H27N5O3/c1-16-7-10-26-23-19(25(32)27-21-9-12-33-15-22(21)31)14-30(24(16)23)13-17-3-5-18(6-4-17)20-8-11-29(2)28-20/h3-8,10-11,14,21-22,31H,9,12-13,15H2,1-2H3,(H,27,32)/t21-,22-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	9	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 26: 650-5 (2016) Article DOI: 10.1016/j.bmcl.2015.11.053 BindingDB Entry DOI: 10.7270/Q29C708F
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50135218 (CHEMBL3747781) Show SMILES O[C@H]1COCC[C@@H]1NC(=O)c1cn(Cc2ccc(cc2)-c2cc[nH]n2)c2cccnc12 |r| Show InChI InChI=1S/C23H23N5O3/c29-21-14-31-11-8-19(21)26-23(30)17-13-28(20-2-1-9-24-22(17)20)12-15-3-5-16(6-4-15)18-7-10-25-27-18/h1-7,9-10,13,19,21,29H,8,11-12,14H2,(H,25,27)(H,26,30)/t19-,21-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	65	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 26: 650-5 (2016) Article DOI: 10.1016/j.bmcl.2015.11.053 BindingDB Entry DOI: 10.7270/Q29C708F
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50240694 (CHEMBL4067722) Show SMILES Cc1cc2CN([C@H]3CCOC[C@@H]3O)C(=O)c2cc1Cc1ccc(cc1)-c1cocn1 |r| Show InChI InChI=1S/C24H24N2O4/c1-15-8-19-11-26(22-6-7-29-13-23(22)27)24(28)20(19)10-18(15)9-16-2-4-17(5-3-16)21-12-30-14-25-21/h2-5,8,10,12,14,22-23,27H,6-7,9,11,13H2,1H3/t22-,23-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Agonist activity at human muscarinic acetylcholine receptor M3 expressed in CHO cells assessed as increase in calcium mobilization incubated for 10 m...				J Med Chem 60: 6649-6663 (2017) Article DOI: 10.1021/acs.jmedchem.7b00597 BindingDB Entry DOI: 10.7270/Q2ZK5JS0
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50240694 (CHEMBL4067722) Show SMILES Cc1cc2CN([C@H]3CCOC[C@@H]3O)C(=O)c2cc1Cc1ccc(cc1)-c1cocn1 |r| Show InChI InChI=1S/C24H24N2O4/c1-15-8-19-11-26(22-6-7-29-13-23(22)27)24(28)20(19)10-18(15)9-16-2-4-17(5-3-16)21-12-30-14-25-21/h2-5,8,10,12,14,22-23,27H,6-7,9,11,13H2,1H3/t22-,23-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Agonist activity at human muscarinic acetylcholine receptor M4 expressed in CHO cells assessed as increase in cAMP accumulation after 2 hrs by cAMP-G...				J Med Chem 60: 6649-6663 (2017) Article DOI: 10.1021/acs.jmedchem.7b00597 BindingDB Entry DOI: 10.7270/Q2ZK5JS0
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50240694 (CHEMBL4067722) Show SMILES Cc1cc2CN([C@H]3CCOC[C@@H]3O)C(=O)c2cc1Cc1ccc(cc1)-c1cocn1 |r| Show InChI InChI=1S/C24H24N2O4/c1-15-8-19-11-26(22-6-7-29-13-23(22)27)24(28)20(19)10-18(15)9-16-2-4-17(5-3-16)21-12-30-14-25-21/h2-5,8,10,12,14,22-23,27H,6-7,9,11,13H2,1H3/t22-,23-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Agonist activity at human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as increase in calcium mobilization incubated for 10 m...				J Med Chem 60: 6649-6663 (2017) Article DOI: 10.1021/acs.jmedchem.7b00597 BindingDB Entry DOI: 10.7270/Q2ZK5JS0
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50240695 (CHEMBL4094233) Show SMILES Cc1cc2CN([C@H]3CCOC[C@@H]3O)C(=O)c2cc1Cc1ccc(cc1)-n1cccn1 |r| Show InChI InChI=1S/C24H25N3O3/c1-16-11-19-14-26(22-7-10-30-15-23(22)28)24(29)21(19)13-18(16)12-17-3-5-20(6-4-17)27-9-2-8-25-27/h2-6,8-9,11,13,22-23,28H,7,10,12,14-15H2,1H3/t22-,23-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	36	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as increase in acetylcholine-induced cal...				J Med Chem 60: 6649-6663 (2017) Article DOI: 10.1021/acs.jmedchem.7b00597 BindingDB Entry DOI: 10.7270/Q2ZK5JS0
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50240699 (CHEMBL4066701) Show SMILES Cc1cc2CCN([C@H]3CCOC[C@@H]3O)C(=O)c2cc1Cc1ccc(cc1)-n1cccn1 |r| Show InChI InChI=1S/C25H27N3O3/c1-17-13-19-7-11-27(23-8-12-31-16-24(23)29)25(30)22(19)15-20(17)14-18-3-5-21(6-4-18)28-10-2-9-26-28/h2-6,9-10,13,15,23-24,29H,7-8,11-12,14,16H2,1H3/t23-,24-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	18	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as increase in acetylcholine-induced cal...				J Med Chem 60: 6649-6663 (2017) Article DOI: 10.1021/acs.jmedchem.7b00597 BindingDB Entry DOI: 10.7270/Q2ZK5JS0
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50240700 (CHEMBL4072572) Show SMILES Cc1cc2CN([C@H]3CCOC[C@@H]3O)C(=O)c2cc1Cc1ccc(cc1)-c1cscn1 |r| Show InChI InChI=1S/C24H24N2O3S/c1-15-8-19-11-26(22-6-7-29-12-23(22)27)24(28)20(19)10-18(15)9-16-2-4-17(5-3-16)21-13-30-14-25-21/h2-5,8,10,13-14,22-23,27H,6-7,9,11-12H2,1H3/t22-,23-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	24	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as increase in acetylcholine-induced cal...				J Med Chem 60: 6649-6663 (2017) Article DOI: 10.1021/acs.jmedchem.7b00597 BindingDB Entry DOI: 10.7270/Q2ZK5JS0
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50240702 (CHEMBL4063980) Show SMILES Cc1nc(co1)-c1ccc(Cc2cc3C(=O)N(Cc3cc2C)[C@H]2CCOC[C@@H]2O)cc1 |r| Show InChI InChI=1S/C25H26N2O4/c1-15-9-20-12-27(23-7-8-30-14-24(23)28)25(29)21(20)11-19(15)10-17-3-5-18(6-4-17)22-13-31-16(2)26-22/h3-6,9,11,13,23-24,28H,7-8,10,12,14H2,1-2H3/t23-,24-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	50	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as increase in acetylcholine-induced cal...				J Med Chem 60: 6649-6663 (2017) Article DOI: 10.1021/acs.jmedchem.7b00597 BindingDB Entry DOI: 10.7270/Q2ZK5JS0
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50240703 (CHEMBL4085548) Show SMILES Cc1nc(co1)-c1ccc(Cc2cc3C(=O)N(CCc3cc2C)[C@H]2CCOC[C@@H]2O)cc1 |r| Show InChI InChI=1S/C26H28N2O4/c1-16-11-20-7-9-28(24-8-10-31-15-25(24)29)26(30)22(20)13-21(16)12-18-3-5-19(6-4-18)23-14-32-17(2)27-23/h3-6,11,13-14,24-25,29H,7-10,12,15H2,1-2H3/t24-,25-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	23	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as increase in acetylcholine-induced cal...				J Med Chem 60: 6649-6663 (2017) Article DOI: 10.1021/acs.jmedchem.7b00597 BindingDB Entry DOI: 10.7270/Q2ZK5JS0
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50240694 (CHEMBL4067722) Show SMILES Cc1cc2CN([C@H]3CCOC[C@@H]3O)C(=O)c2cc1Cc1ccc(cc1)-c1cocn1 |r| Show InChI InChI=1S/C24H24N2O4/c1-15-8-19-11-26(22-6-7-29-13-23(22)27)24(28)20(19)10-18(15)9-16-2-4-17(5-3-16)21-12-30-14-25-21/h2-5,8,10,12,14,22-23,27H,6-7,9,11,13H2,1H3/t22-,23-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	47	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as increase in acetylcholine-induced cal...				J Med Chem 60: 6649-6663 (2017) Article DOI: 10.1021/acs.jmedchem.7b00597 BindingDB Entry DOI: 10.7270/Q2ZK5JS0
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50240704 (CHEMBL4088915) Show SMILES Cc1cc2CN([C@H]3CCOC[C@@H]3O)C(=O)c2cc1Cc1ccc(cc1)-c1cnn(C)c1 |r| Show InChI InChI=1S/C25H27N3O3/c1-16-9-20-14-28(23-7-8-31-15-24(23)29)25(30)22(20)11-19(16)10-17-3-5-18(6-4-17)21-12-26-27(2)13-21/h3-6,9,11-13,23-24,29H,7-8,10,14-15H2,1-2H3/t23-,24-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	27	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as increase in acetylcholine-induced cal...				J Med Chem 60: 6649-6663 (2017) Article DOI: 10.1021/acs.jmedchem.7b00597 BindingDB Entry DOI: 10.7270/Q2ZK5JS0
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50240705 (CHEMBL4067692) Show SMILES Cc1cc2CN([C@H]3CCOC[C@@H]3O)C(=O)c2cc1Cc1ccc(cc1)-n1ccnc1 |r| Show InChI InChI=1S/C24H25N3O3/c1-16-10-19-13-27(22-6-9-30-14-23(22)28)24(29)21(19)12-18(16)11-17-2-4-20(5-3-17)26-8-7-25-15-26/h2-5,7-8,10,12,15,22-23,28H,6,9,11,13-14H2,1H3/t22-,23-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	68	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as increase in acetylcholine-induced cal...				J Med Chem 60: 6649-6663 (2017) Article DOI: 10.1021/acs.jmedchem.7b00597 BindingDB Entry DOI: 10.7270/Q2ZK5JS0
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50240692 (CHEMBL4078588) Show SMILES Cc1ccc(Cc2cc3c(ncn([C@H]4CCCC[C@@H]4O)c3=O)c3ccccc23)cn1 |r| Show InChI InChI=1S/C25H25N3O2/c1-16-10-11-17(14-26-16)12-18-13-21-24(20-7-3-2-6-19(18)20)27-15-28(25(21)30)22-8-4-5-9-23(22)29/h2-3,6-7,10-11,13-15,22-23,29H,4-5,8-9,12H2,1H3/t22-,23-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	63	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as increase in acetylcholine-induced cal...				J Med Chem 60: 6649-6663 (2017) Article DOI: 10.1021/acs.jmedchem.7b00597 BindingDB Entry DOI: 10.7270/Q2ZK5JS0
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50135213 (CHEMBL3747016) Show SMILES Cn1ccc(n1)-c1ccc(Cn2cc(C(=O)N[C@H]3CCOC[C@@H]3O)c3ncccc23)cc1 |r| Show InChI InChI=1S/C24H25N5O3/c1-28-11-8-19(27-28)17-6-4-16(5-7-17)13-29-14-18(23-21(29)3-2-10-25-23)24(31)26-20-9-12-32-15-22(20)30/h2-8,10-11,14,20,22,30H,9,12-13,15H2,1H3,(H,26,31)/t20-,22-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	55	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as increase in acetylcholine-induced cal...				J Med Chem 60: 6649-6663 (2017) Article DOI: 10.1021/acs.jmedchem.7b00597 BindingDB Entry DOI: 10.7270/Q2ZK5JS0
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50240693 (CHEMBL4097569) Show SMILES Cc1cnc(cc1Cc1ccc(cc1)-c1cscn1)C(=O)N[C@H]1CCOC[C@@H]1O |r| Show InChI InChI=1S/C22H23N3O3S/c1-14-10-23-19(22(27)25-18-6-7-28-11-21(18)26)9-17(14)8-15-2-4-16(5-3-15)20-12-29-13-24-20/h2-5,9-10,12-13,18,21,26H,6-8,11H2,1H3,(H,25,27)/t18-,21-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	60	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as increase in acetylcholine-induced cal...				J Med Chem 60: 6649-6663 (2017) Article DOI: 10.1021/acs.jmedchem.7b00597 BindingDB Entry DOI: 10.7270/Q2ZK5JS0
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50240692 (CHEMBL4078588) Show SMILES Cc1ccc(Cc2cc3c(ncn([C@H]4CCCC[C@@H]4O)c3=O)c3ccccc23)cn1 |r| Show InChI InChI=1S/C25H25N3O2/c1-16-10-11-17(14-26-16)12-18-13-21-24(20-7-3-2-6-19(18)20)27-15-28(25(21)30)22-8-4-5-9-23(22)29/h2-3,6-7,10-11,13-15,22-23,29H,4-5,8-9,12H2,1H3/t22-,23-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>2.00E+3	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Agonist activity at human muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as increase in calcium mobilization incubated for 10 m...				J Med Chem 60: 6649-6663 (2017) Article DOI: 10.1021/acs.jmedchem.7b00597 BindingDB Entry DOI: 10.7270/Q2ZK5JS0
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50135213 (CHEMBL3747016) Show SMILES Cn1ccc(n1)-c1ccc(Cn2cc(C(=O)N[C@H]3CCOC[C@@H]3O)c3ncccc23)cc1 |r| Show InChI InChI=1S/C24H25N5O3/c1-28-11-8-19(27-28)17-6-4-16(5-7-17)13-29-14-18(23-21(29)3-2-10-25-23)24(31)26-20-9-12-32-15-22(20)30/h2-8,10-11,14,20,22,30H,9,12-13,15H2,1H3,(H,26,31)/t20-,22-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Agonist activity at human muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as increase in calcium mobilization incubated for 10 m...				J Med Chem 60: 6649-6663 (2017) Article DOI: 10.1021/acs.jmedchem.7b00597 BindingDB Entry DOI: 10.7270/Q2ZK5JS0
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50240693 (CHEMBL4097569) Show SMILES Cc1cnc(cc1Cc1ccc(cc1)-c1cscn1)C(=O)N[C@H]1CCOC[C@@H]1O |r| Show InChI InChI=1S/C22H23N3O3S/c1-14-10-23-19(22(27)25-18-6-7-28-11-21(18)26)9-17(14)8-15-2-4-16(5-3-15)20-12-29-13-24-20/h2-5,9-10,12-13,18,21,26H,6-8,11H2,1H3,(H,25,27)/t18-,21-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>4.00E+3	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Agonist activity at human muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as increase in calcium mobilization incubated for 10 m...				J Med Chem 60: 6649-6663 (2017) Article DOI: 10.1021/acs.jmedchem.7b00597 BindingDB Entry DOI: 10.7270/Q2ZK5JS0
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM50240694 (CHEMBL4067722) Show SMILES Cc1cc2CN([C@H]3CCOC[C@@H]3O)C(=O)c2cc1Cc1ccc(cc1)-c1cocn1 |r| Show InChI InChI=1S/C24H24N2O4/c1-15-8-19-11-26(22-6-7-29-13-23(22)27)24(28)20(19)10-18(15)9-16-2-4-17(5-3-16)21-12-30-14-25-21/h2-5,8,10,12,14,22-23,27H,6-7,9,11,13H2,1H3/t22-,23-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Agonist activity at human muscarinic acetylcholine receptor M2 expressed in CHO cells assessed as increase in cAMP accumulation after 2 hrs by cAMP-G...				J Med Chem 60: 6649-6663 (2017) Article DOI: 10.1021/acs.jmedchem.7b00597 BindingDB Entry DOI: 10.7270/Q2ZK5JS0
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50240706 (CHEMBL4093295) Show SMILES Cc1cc2CCN([C@H]3CCOC[C@@H]3O)C(=O)c2cc1Cc1ccc(cc1)-c1cscn1 |r| Show InChI InChI=1S/C25H26N2O3S/c1-16-10-19-6-8-27(23-7-9-30-13-24(23)28)25(29)21(19)12-20(16)11-17-2-4-18(5-3-17)22-14-31-15-26-22/h2-5,10,12,14-15,23-24,28H,6-9,11,13H2,1H3/t23-,24-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	7	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as increase in acetylcholine-induced cal...				J Med Chem 60: 6649-6663 (2017) Article DOI: 10.1021/acs.jmedchem.7b00597 BindingDB Entry DOI: 10.7270/Q2ZK5JS0
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50240707 (CHEMBL4088940) Show SMILES Cc1cc2CCN([C@H]3CCOC[C@@H]3O)C(=O)c2cc1Cc1ccc(cc1)-c1cocn1 |r| Show InChI InChI=1S/C25H26N2O4/c1-16-10-19-6-8-27(23-7-9-30-14-24(23)28)25(29)21(19)12-20(16)11-17-2-4-18(5-3-17)22-13-31-15-26-22/h2-5,10,12-13,15,23-24,28H,6-9,11,14H2,1H3/t23-,24-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	26	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as increase in acetylcholine-induced cal...				J Med Chem 60: 6649-6663 (2017) Article DOI: 10.1021/acs.jmedchem.7b00597 BindingDB Entry DOI: 10.7270/Q2ZK5JS0
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50240708 (CHEMBL4096607) Show SMILES Cc1cn(cn1)-c1ccc(Cc2cc3C(=O)N(Cc3cc2C)[C@H]2CCOC[C@@H]2O)cc1 |r| Show InChI InChI=1S/C25H27N3O3/c1-16-9-20-13-28(23-7-8-31-14-24(23)29)25(30)22(20)11-19(16)10-18-3-5-21(6-4-18)27-12-17(2)26-15-27/h3-6,9,11-12,15,23-24,29H,7-8,10,13-14H2,1-2H3/t23-,24-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	45	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as increase in acetylcholine-induced cal...				J Med Chem 60: 6649-6663 (2017) Article DOI: 10.1021/acs.jmedchem.7b00597 BindingDB Entry DOI: 10.7270/Q2ZK5JS0
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50240693 (CHEMBL4097569) Show SMILES Cc1cnc(cc1Cc1ccc(cc1)-c1cscn1)C(=O)N[C@H]1CCOC[C@@H]1O |r| Show InChI InChI=1S/C22H23N3O3S/c1-14-10-23-19(22(27)25-18-6-7-28-11-21(18)26)9-17(14)8-15-2-4-16(5-3-15)20-12-29-13-24-20/h2-5,9-10,12-13,18,21,26H,6-8,11H2,1H3,(H,25,27)/t18-,21-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a
TBA					Assay Description Partial agonist activity at muscarinic M1 receptor (unknown origin) assessed as recruitment of beta-arrestin by Path Hunter assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.6b00544 BindingDB Entry DOI: 10.7270/Q2MC93Q2
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50240693 (CHEMBL4097569) Show SMILES Cc1cnc(cc1Cc1ccc(cc1)-c1cscn1)C(=O)N[C@H]1CCOC[C@@H]1O |r| Show InChI InChI=1S/C22H23N3O3S/c1-14-10-23-19(22(27)25-18-6-7-28-11-21(18)26)9-17(14)8-15-2-4-16(5-3-15)20-12-29-13-24-20/h2-5,9-10,12-13,18,21,26H,6-8,11H2,1H3,(H,25,27)/t18-,21-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	365	n/a	n/a	n/a	n/a
TBA					Assay Description Positive allosteric modulation of muscarinic M1 receptor (unknown origin) assessed as increase in Ach-induced recruitment of beta-arrestin by Path Hu...				Citation and Details Article DOI: 10.1021/acs.jmedchem.6b00544 BindingDB Entry DOI: 10.7270/Q2MC93Q2
					More data for this Ligand-Target Pair

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