Found 920 hits of ic50 data for polymerid = 50002247,50006473 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50339190
(CHEMBL443683 | telomestatin)Show SMILES Cc1oc2nc1c1nc(co1)c1nc(co1)c1nc(co1)c1nc(co1)c1nc(co1)c1SCc(n1)c1[nH]c2c(C)o1 Show InChI InChI=1S/C26H14N8O7S/c1-9-17-24-30-14(6-39-24)21-28-12(4-37-21)19-27-11(3-35-19)20-29-13(5-36-20)22-31-15(7-38-22)26-32-16(8-42-26)23-33-18(10(2)40-23)25(34-17)41-9/h3-7,33H,8H2,1-2H3/b20-11+,21-14+,26-15+ | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 0.640 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut National de la Sant£ et de la Recherche M£dicale
Curated by ChEMBL
| Assay Description
Inhibition of human telomerase expressed in HEK293T cells treated before telomerase elongation by telomeric repeat amplification protocol assay |
Proc Natl Acad Sci USA 104: 17347-52 (2007)
Article DOI: 10.1073/pnas.0707365104
BindingDB Entry DOI: 10.7270/Q26974FQ |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50339190
(CHEMBL443683 | telomestatin)Show SMILES Cc1oc2nc1c1nc(co1)c1nc(co1)c1nc(co1)c1nc(co1)c1nc(co1)c1SCc(n1)c1[nH]c2c(C)o1 Show InChI InChI=1S/C26H14N8O7S/c1-9-17-24-30-14(6-39-24)21-28-12(4-37-21)19-27-11(3-35-19)20-29-13(5-36-20)22-31-15(7-38-22)26-32-16(8-42-26)23-33-18(10(2)40-23)25(34-17)41-9/h3-7,33H,8H2,1-2H3/b20-11+,21-14+,26-15+ | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut National de la Sant£ et de la Recherche M£dicale
Curated by ChEMBL
| Assay Description
Inhibition of human telomerase expressed in HEK293T cells treated after telomerase elongation by telomeric repeat amplification protocol assay |
Proc Natl Acad Sci USA 104: 17347-52 (2007)
Article DOI: 10.1073/pnas.0707365104
BindingDB Entry DOI: 10.7270/Q26974FQ |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50339190
(CHEMBL443683 | telomestatin)Show SMILES Cc1oc2nc1c1nc(co1)c1nc(co1)c1nc(co1)c1nc(co1)c1nc(co1)c1SCc(n1)c1[nH]c2c(C)o1 Show InChI InChI=1S/C26H14N8O7S/c1-9-17-24-30-14(6-39-24)21-28-12(4-37-21)19-27-11(3-35-19)20-29-13(5-36-20)22-31-15(7-38-22)26-32-16(8-42-26)23-33-18(10(2)40-23)25(34-17)41-9/h3-7,33H,8H2,1-2H3/b20-11+,21-14+,26-15+ | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Universita` degli Studi La Sapienza
Curated by ChEMBL
| Assay Description
Inhibition of human Telomerase activity in cell free system by TRAP assay |
J Med Chem 54: 1140-56 (2011)
Article DOI: 10.1021/jm1013665
BindingDB Entry DOI: 10.7270/Q2GB24CR |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50376748
(CHEMBL259739 | Phen-DC3)Show SMILES C[n+]1cc(NC(=O)c2ccc3ccc4ccc(nc4c3n2)C(=O)Nc2c[n+](C)c3ccccc3c2)cc2ccccc12 Show InChI InChI=1S/C34H24N6O2/c1-39-19-25(17-23-7-3-5-9-29(23)39)35-33(41)27-15-13-21-11-12-22-14-16-28(38-32(22)31(21)37-27)34(42)36-26-18-24-8-4-6-10-30(24)40(2)20-26/h3-20H,1-2H3/p+2 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
MMDB
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut National de la Sant£ et de la Recherche M£dicale
Curated by ChEMBL
| Assay Description
Inhibition of human telomerase expressed in HEK293T cells treated before telomerase elongation by telomeric repeat amplification protocol assay |
Proc Natl Acad Sci USA 104: 17347-52 (2007)
Article DOI: 10.1073/pnas.0707365104
BindingDB Entry DOI: 10.7270/Q26974FQ |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50376748
(CHEMBL259739 | Phen-DC3)Show SMILES C[n+]1cc(NC(=O)c2ccc3ccc4ccc(nc4c3n2)C(=O)Nc2c[n+](C)c3ccccc3c2)cc2ccccc12 Show InChI InChI=1S/C34H24N6O2/c1-39-19-25(17-23-7-3-5-9-29(23)39)35-33(41)27-15-13-21-11-12-22-14-16-28(38-32(22)31(21)37-27)34(42)36-26-18-24-8-4-6-10-30(24)40(2)20-26/h3-20H,1-2H3/p+2 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
MMDB
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut National de la Sant£ et de la Recherche M£dicale
Curated by ChEMBL
| Assay Description
Inhibition of human telomerase expressed in HEK293T cells treated after telomerase elongation by telomeric repeat amplification protocol assay |
Proc Natl Acad Sci USA 104: 17347-52 (2007)
Article DOI: 10.1073/pnas.0707365104
BindingDB Entry DOI: 10.7270/Q26974FQ |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50198341
(CHEMBL3948172)Show InChI InChI=1S/C10H14O4/c1-7-3-2-6-10(13-7)8(11)4-5-9(12)14-10/h4-5,7,9,12H,2-3,6H2,1H3 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Istituto di Farmacologia Traslazionale
Curated by ChEMBL
| Assay Description
Inhibition of telomerase activity in human M14 cells using biotin-labeled TeloTAGGG as primer preincubated for 48 hrs followed by primer addition mea... |
J Med Chem 59: 9140-9149 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01046
BindingDB Entry DOI: 10.7270/Q2NC6352 |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50198341
(CHEMBL3948172)Show InChI InChI=1S/C10H14O4/c1-7-3-2-6-10(13-7)8(11)4-5-9(12)14-10/h4-5,7,9,12H,2-3,6H2,1H3 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Istituto di Farmacologia Traslazionale
Curated by ChEMBL
| Assay Description
Inhibition of telomerase activity in human HT-29 cells using biotin-labeled TeloTAGGG as primer preincubated for 48 hrs followed by primer addition m... |
J Med Chem 59: 9140-9149 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01046
BindingDB Entry DOI: 10.7270/Q2NC6352 |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50198341
(CHEMBL3948172)Show InChI InChI=1S/C10H14O4/c1-7-3-2-6-10(13-7)8(11)4-5-9(12)14-10/h4-5,7,9,12H,2-3,6H2,1H3 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Istituto di Farmacologia Traslazionale
Curated by ChEMBL
| Assay Description
Inhibition of telomerase activity in human H125 cells using biotin-labeled TeloTAGGG as primer preincubated for 48 hrs followed by primer addition me... |
J Med Chem 59: 9140-9149 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01046
BindingDB Entry DOI: 10.7270/Q2NC6352 |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50198341
(CHEMBL3948172)Show InChI InChI=1S/C10H14O4/c1-7-3-2-6-10(13-7)8(11)4-5-9(12)14-10/h4-5,7,9,12H,2-3,6H2,1H3 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Istituto di Farmacologia Traslazionale
Curated by ChEMBL
| Assay Description
Inhibition of telomerase activity in human MCF7 cells using biotin-labeled TeloTAGGG as primer preincubated for 48 hrs followed by primer addition me... |
J Med Chem 59: 9140-9149 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01046
BindingDB Entry DOI: 10.7270/Q2NC6352 |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50310892
(CHEMBL1078511 | N,N'-(9-(2-(1-methylpyrrolidin-2-y...)Show SMILES CN1CCCC1CCNc1c2ccc(NC(=O)CCN3CCCC3)cc2nc2cc(NC(=O)CCN3CCCC3)ccc12 Show InChI InChI=1S/C34H47N7O2/c1-39-16-6-7-27(39)12-15-35-34-28-10-8-25(36-32(42)13-21-40-17-2-3-18-40)23-30(28)38-31-24-26(9-11-29(31)34)37-33(43)14-22-41-19-4-5-20-41/h8-11,23-24,27H,2-7,12-22H2,1H3,(H,35,38)(H,36,42)(H,37,43) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Central University of Las Villas
Curated by ChEMBL
| Assay Description
Inhibition of telomerase in human A2780 cells by TRAP assay |
Eur J Med Chem 44: 4826-40 (2009)
Article DOI: 10.1016/j.ejmech.2009.07.029
BindingDB Entry DOI: 10.7270/Q20R9PHM |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50310892
(CHEMBL1078511 | N,N'-(9-(2-(1-methylpyrrolidin-2-y...)Show SMILES CN1CCCC1CCNc1c2ccc(NC(=O)CCN3CCCC3)cc2nc2cc(NC(=O)CCN3CCCC3)ccc12 Show InChI InChI=1S/C34H47N7O2/c1-39-16-6-7-27(39)12-15-35-34-28-10-8-25(36-32(42)13-21-40-17-2-3-18-40)23-30(28)38-31-24-26(9-11-29(31)34)37-33(43)14-22-41-19-4-5-20-41/h8-11,23-24,27H,2-7,12-22H2,1H3,(H,35,38)(H,36,42)(H,37,43) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi"Magna Gr£cia"
Curated by ChEMBL
| Assay Description
Inhibition of telomerase (unknown origin) by TRAP assay |
Eur J Med Chem 68: 139-49 (2013)
Article DOI: 10.1016/j.ejmech.2013.07.022
BindingDB Entry DOI: 10.7270/Q24J0GJB |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50134027
(CHEMBL140180 | N,N'-(9-(2-(dimethylamino)ethylamin...)Show SMILES CN(C)CCNc1c2ccc(NC(=O)CCN3CCCC3)cc2nc2cc(NC(=O)CCN3CCCC3)ccc12 Show InChI InChI=1S/C31H43N7O2/c1-36(2)20-13-32-31-25-9-7-23(33-29(39)11-18-37-14-3-4-15-37)21-27(25)35-28-22-24(8-10-26(28)31)34-30(40)12-19-38-16-5-6-17-38/h7-10,21-22H,3-6,11-20H2,1-2H3,(H,32,35)(H,33,39)(H,34,40) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Central University of Las Villas
Curated by ChEMBL
| Assay Description
Inhibition of telomerase in human A2780 cells by TRAP assay |
Eur J Med Chem 44: 4826-40 (2009)
Article DOI: 10.1016/j.ejmech.2009.07.029
BindingDB Entry DOI: 10.7270/Q20R9PHM |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50134010
(CHEMBL139511 | N,N'-(9-(2-aminophenylamino)acridin...)Show SMILES Nc1ccccc1Nc1c2ccc(NC(=O)CCN3CCCC3)cc2nc2cc(NC(=O)CCN3CCCC3)ccc12 Show InChI InChI=1S/C33H39N7O2/c34-27-7-1-2-8-28(27)38-33-25-11-9-23(35-31(41)13-19-39-15-3-4-16-39)21-29(25)37-30-22-24(10-12-26(30)33)36-32(42)14-20-40-17-5-6-18-40/h1-2,7-12,21-22H,3-6,13-20,34H2,(H,35,41)(H,36,42)(H,37,38) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Central University of Las Villas
Curated by ChEMBL
| Assay Description
Inhibition of telomerase in human A2780 cells by TRAP assay |
Eur J Med Chem 44: 4826-40 (2009)
Article DOI: 10.1016/j.ejmech.2009.07.029
BindingDB Entry DOI: 10.7270/Q20R9PHM |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50440391
(CHEMBL2425367)Show SMILES CN(C)CCCNCc1ccc2nc3c(ccc4nc5ccc(CNCCCN(C)C)cc5cc34)cc2c1 Show InChI InChI=1S/C32H40N6/c1-37(2)15-5-13-33-21-23-8-11-30-26(17-23)19-25-9-12-31-28(32(25)36-30)20-27-18-24(7-10-29(27)35-31)22-34-14-6-16-38(3)4/h7-12,17-20,33-34H,5-6,13-16,21-22H2,1-4H3 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi"Magna Gr£cia"
Curated by ChEMBL
| Assay Description
Inhibition of telomerase (unknown origin) by TRAP assay |
Eur J Med Chem 68: 139-49 (2013)
Article DOI: 10.1016/j.ejmech.2013.07.022
BindingDB Entry DOI: 10.7270/Q24J0GJB |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50196500
(CHEMBL224754 | trimethyl(2-{6,8,17,19-tetraoxo-18-...)Show SMILES C[N+](C)(C)CCn1c(=O)c2ccc3c4ccc5c6c(ccc(c7ccc(c2c37)c1=O)c46)c(=O)n(CC[N+](C)(C)C)c5=O Show InChI InChI=1S/C34H34N4O4/c1-37(2,3)17-15-35-31(39)23-11-7-19-21-9-13-25-30-26(34(42)36(33(25)41)16-18-38(4,5)6)14-10-22(28(21)30)20-8-12-24(32(35)40)29(23)27(19)20/h7-14H,15-18H2,1-6H3/q+2 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Padova
Curated by ChEMBL
| Assay Description
Inhibition of telomerase in JR8 cell extract by TRAP assay |
Bioorg Med Chem 15: 555-62 (2006)
Article DOI: 10.1016/j.bmc.2006.09.029
BindingDB Entry DOI: 10.7270/Q2QC033H |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50134022
(CHEMBL336444 | N,N'-(9-(4-acetylphenylamino)acridi...)Show SMILES CC(=O)c1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)cc1 Show InChI InChI=1S/C35H40N6O3/c1-24(42)25-6-8-26(9-7-25)38-35-29-12-10-27(36-33(43)14-20-40-16-2-3-17-40)22-31(29)39-32-23-28(11-13-30(32)35)37-34(44)15-21-41-18-4-5-19-41/h6-13,22-23H,2-5,14-21H2,1H3,(H,36,43)(H,37,44)(H,38,39) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Central University of Las Villas
Curated by ChEMBL
| Assay Description
Inhibition of telomerase in human A2780 cells by TRAP assay |
Eur J Med Chem 44: 4826-40 (2009)
Article DOI: 10.1016/j.ejmech.2009.07.029
BindingDB Entry DOI: 10.7270/Q20R9PHM |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50487893
(CHEMBL2260109)Show SMILES CSc1nc(Nc2ccc3nc(C)cc(N(C)C)c3c2)nc(Nc2ccc3nc(C)cc(N(C)C)c3c2)n1 Show InChI InChI=1S/C28H31N9S/c1-16-12-24(36(3)4)20-14-18(8-10-22(20)29-16)31-26-33-27(35-28(34-26)38-7)32-19-9-11-23-21(15-19)25(37(5)6)13-17(2)30-23/h8-15H,1-7H3,(H2,31,32,33,34,35) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of telomerase (unknown origin) |
Citation and Details
Article DOI: 10.1007/s00044-012-0447-6
BindingDB Entry DOI: 10.7270/Q2N87DPV |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50487893
(CHEMBL2260109)Show SMILES CSc1nc(Nc2ccc3nc(C)cc(N(C)C)c3c2)nc(Nc2ccc3nc(C)cc(N(C)C)c3c2)n1 Show InChI InChI=1S/C28H31N9S/c1-16-12-24(36(3)4)20-14-18(8-10-22(20)29-16)31-26-33-27(35-28(34-26)38-7)32-19-9-11-23-21(15-19)25(37(5)6)13-17(2)30-23/h8-15H,1-7H3,(H2,31,32,33,34,35) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of telomerase (unknown origin) |
Citation and Details
Article DOI: 10.1007/s00044-012-0447-6
BindingDB Entry DOI: 10.7270/Q2N87DPV |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50134030
(9-[4-(N,N-dimethylamino)phenylamino]-3,6-bis(3-pyr...)Show SMILES CN(C)c1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)cc1 Show InChI InChI=1S/C35H43N7O2/c1-40(2)28-11-7-25(8-12-28)38-35-29-13-9-26(36-33(43)15-21-41-17-3-4-18-41)23-31(29)39-32-24-27(10-14-30(32)35)37-34(44)16-22-42-19-5-6-20-42/h7-14,23-24H,3-6,15-22H2,1-2H3,(H,36,43)(H,37,44)(H,38,39) | PDB
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Institut National de la Sant£ et de la Recherche M£dicale
Curated by ChEMBL
| Assay Description
Inhibition of human telomerase expressed in HEK293T cells treated before telomerase elongation by telomeric repeat amplification protocol assay |
Proc Natl Acad Sci USA 104: 17347-52 (2007)
Article DOI: 10.1073/pnas.0707365104
BindingDB Entry DOI: 10.7270/Q26974FQ |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50376747
(CHEMBL409247)Show SMILES C[n+]1cc(NC(=O)c2cccc(n2)C(=O)Nc2c[n+](C)c3ccccc3c2)cc2ccccc12 Show InChI InChI=1S/C27H21N5O2/c1-31-16-20(14-18-8-3-5-12-24(18)31)28-26(33)22-10-7-11-23(30-22)27(34)29-21-15-19-9-4-6-13-25(19)32(2)17-21/h3-17H,1-2H3/p+2 | PDB
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Institut National de la Sant£ et de la Recherche M£dicale
Curated by ChEMBL
| Assay Description
Inhibition of human telomerase expressed in in HEK293T cells in presence of primer (T2AG3)4 by primer extension assay |
Proc Natl Acad Sci USA 104: 17347-52 (2007)
Article DOI: 10.1073/pnas.0707365104
BindingDB Entry DOI: 10.7270/Q26974FQ |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50489002
(CHEMBL2298058)Show SMILES CSc1nc(Nc2ccc3nc(C)cc(N)c3c2)nc(Nc2ccc3nc(C)cc(N)c3c2)n1 Show InChI InChI=1S/C24H23N9S/c1-12-8-18(25)16-10-14(4-6-20(16)27-12)29-22-31-23(33-24(32-22)34-3)30-15-5-7-21-17(11-15)19(26)9-13(2)28-21/h4-11H,1-3H3,(H2,25,27)(H2,26,28)(H2,29,30,31,32,33) | PDB
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UniChem
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TBA
| Assay Description
Inhibition of telomerase (unknown origin) |
Citation and Details
Article DOI: 10.1007/s00044-012-0447-6
BindingDB Entry DOI: 10.7270/Q2N87DPV |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50489002
(CHEMBL2298058)Show SMILES CSc1nc(Nc2ccc3nc(C)cc(N)c3c2)nc(Nc2ccc3nc(C)cc(N)c3c2)n1 Show InChI InChI=1S/C24H23N9S/c1-12-8-18(25)16-10-14(4-6-20(16)27-12)29-22-31-23(33-24(32-22)34-3)30-15-5-7-21-17(11-15)19(26)9-13(2)28-21/h4-11H,1-3H3,(H2,25,27)(H2,26,28)(H2,29,30,31,32,33) | PDB
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| n/a | n/a | 49 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of telomerase (unknown origin) |
Citation and Details
Article DOI: 10.1007/s00044-012-0447-6
BindingDB Entry DOI: 10.7270/Q2N87DPV |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50134032
(CHEMBL138811 | N,N'-(9-(cyclopropylamino)acridine-...)Show SMILES O=C(CCN1CCCC1)Nc1ccc2c(NC3CC3)c3ccc(NC(=O)CCN4CCCC4)cc3nc2c1 Show InChI InChI=1S/C30H38N6O2/c37-28(11-17-35-13-1-2-14-35)31-22-7-9-24-26(19-22)34-27-20-23(8-10-25(27)30(24)33-21-5-6-21)32-29(38)12-18-36-15-3-4-16-36/h7-10,19-21H,1-6,11-18H2,(H,31,37)(H,32,38)(H,33,34) | PDB
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| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Central University of Las Villas
Curated by ChEMBL
| Assay Description
Inhibition of telomerase in human A2780 cells by TRAP assay |
Eur J Med Chem 44: 4826-40 (2009)
Article DOI: 10.1016/j.ejmech.2009.07.029
BindingDB Entry DOI: 10.7270/Q20R9PHM |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50058033
(CHEMBL3330787)Show SMILES Cl.CNCCNc1c2C(=O)c3ccccc3C(=O)c2c(NCCNC(N)=N)c2sccc12 Show InChI InChI=1S/C22H24N6O2S.ClH/c1-25-7-8-26-17-14-6-11-31-21(14)18(27-9-10-28-22(23)24)16-15(17)19(29)12-4-2-3-5-13(12)20(16)30;/h2-6,11,25-27H,7-10H2,1H3,(H4,23,24,28);1H | PDB
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Russian Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of human telomerase transfected in human HEK293T cells assessed as DNA extension using 5'-d(AATCCGTCGAGCAGAGTT)-3' substrate by Real-time ... |
Eur J Med Chem 85: 605-14 (2014)
Article DOI: 10.1016/j.ejmech.2014.08.030
BindingDB Entry DOI: 10.7270/Q2FX7C4Z |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50134002
(CHEMBL141540 | N,N'-(9-(2-(piperidin-1-yl)ethylami...)Show SMILES O=C(CCN1CCCC1)Nc1ccc2c(NCCN3CCCCC3)c3ccc(NC(=O)CCN4CCCC4)cc3nc2c1 Show InChI InChI=1S/C34H47N7O2/c42-32(12-21-39-17-4-5-18-39)36-26-8-10-28-30(24-26)38-31-25-27(37-33(43)13-22-40-19-6-7-20-40)9-11-29(31)34(28)35-14-23-41-15-2-1-3-16-41/h8-11,24-25H,1-7,12-23H2,(H,35,38)(H,36,42)(H,37,43) | PDB
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Central University of Las Villas
Curated by ChEMBL
| Assay Description
Inhibition of telomerase in human A2780 cells by TRAP assay |
Eur J Med Chem 44: 4826-40 (2009)
Article DOI: 10.1016/j.ejmech.2009.07.029
BindingDB Entry DOI: 10.7270/Q20R9PHM |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50489008
(CHEMBL2298055)Show SMILES Cc1cc(N)c2cc(Nc3nc(N)nc(Nc4ccc5nc(C)cc(N)c5c4)n3)ccc2n1 Show InChI InChI=1S/C23H22N10/c1-11-7-17(24)15-9-13(3-5-19(15)27-11)29-22-31-21(26)32-23(33-22)30-14-4-6-20-16(10-14)18(25)8-12(2)28-20/h3-10H,1-2H3,(H2,24,27)(H2,25,28)(H4,26,29,30,31,32,33) | PDB
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UniChem
| Article
| n/a | n/a | 51 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of telomerase (unknown origin) |
Citation and Details
Article DOI: 10.1007/s00044-012-0447-6
BindingDB Entry DOI: 10.7270/Q2N87DPV |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50489008
(CHEMBL2298055)Show SMILES Cc1cc(N)c2cc(Nc3nc(N)nc(Nc4ccc5nc(C)cc(N)c5c4)n3)ccc2n1 Show InChI InChI=1S/C23H22N10/c1-11-7-17(24)15-9-13(3-5-19(15)27-11)29-22-31-21(26)32-23(33-22)30-14-4-6-20-16(10-14)18(25)8-12(2)28-20/h3-10H,1-2H3,(H2,24,27)(H2,25,28)(H4,26,29,30,31,32,33) | PDB
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| Article
| n/a | n/a | 51 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of telomerase (unknown origin) |
Citation and Details
Article DOI: 10.1007/s00044-012-0447-6
BindingDB Entry DOI: 10.7270/Q2N87DPV |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50376747
(CHEMBL409247)Show SMILES C[n+]1cc(NC(=O)c2cccc(n2)C(=O)Nc2c[n+](C)c3ccccc3c2)cc2ccccc12 Show InChI InChI=1S/C27H21N5O2/c1-31-16-20(14-18-8-3-5-12-24(18)31)28-26(33)22-10-7-11-23(30-22)27(34)29-21-15-19-9-4-6-13-25(19)32(2)17-21/h3-17H,1-2H3/p+2 | PDB
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| n/a | n/a | 52 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut National de la Sant£ et de la Recherche M£dicale
Curated by ChEMBL
| Assay Description
Inhibition of human telomerase expressed in HEK293T cells treated before telomerase elongation by telomeric repeat amplification protocol assay |
Proc Natl Acad Sci USA 104: 17347-52 (2007)
Article DOI: 10.1073/pnas.0707365104
BindingDB Entry DOI: 10.7270/Q26974FQ |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50488996
(CHEMBL2298050)Show SMILES CC[n+]1c(C)cc(N)c2cc(Nc3nc(N)nc(Nc4ccc5[n+](CC)c(C)cc(N)c5c4)n3)ccc12 Show InChI InChI=1S/C27H30N10/c1-5-36-15(3)11-21(28)19-13-17(7-9-23(19)36)31-26-33-25(30)34-27(35-26)32-18-8-10-24-20(14-18)22(29)12-16(4)37(24)6-2/h7-14,28-29H,5-6H2,1-4H3,(H4,30,31,32,33,34,35)/p+2 | PDB
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| n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of telomerase (unknown origin) |
Citation and Details
Article DOI: 10.1007/s00044-012-0447-6
BindingDB Entry DOI: 10.7270/Q2N87DPV |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50488996
(CHEMBL2298050)Show SMILES CC[n+]1c(C)cc(N)c2cc(Nc3nc(N)nc(Nc4ccc5[n+](CC)c(C)cc(N)c5c4)n3)ccc12 Show InChI InChI=1S/C27H30N10/c1-5-36-15(3)11-21(28)19-13-17(7-9-23(19)36)31-26-33-25(30)34-27(35-26)32-18-8-10-24-20(14-18)22(29)12-16(4)37(24)6-2/h7-14,28-29H,5-6H2,1-4H3,(H4,30,31,32,33,34,35)/p+2 | PDB
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UniChem
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| n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of telomerase (unknown origin) |
Citation and Details
Article DOI: 10.1007/s00044-012-0447-6
BindingDB Entry DOI: 10.7270/Q2N87DPV |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50339190
(CHEMBL443683 | telomestatin)Show SMILES Cc1oc2nc1c1nc(co1)c1nc(co1)c1nc(co1)c1nc(co1)c1nc(co1)c1SCc(n1)c1[nH]c2c(C)o1 Show InChI InChI=1S/C26H14N8O7S/c1-9-17-24-30-14(6-39-24)21-28-12(4-37-21)19-27-11(3-35-19)20-29-13(5-36-20)22-31-15(7-38-22)26-32-16(8-42-26)23-33-18(10(2)40-23)25(34-17)41-9/h3-7,33H,8H2,1-2H3/b20-11+,21-14+,26-15+ | PDB
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Institut National de la Sant£ et de la Recherche M£dicale
Curated by ChEMBL
| Assay Description
Inhibition of human telomerase expressed in in HEK293T cells in presence of primer (T2AG3)4 by primer extension assay |
Proc Natl Acad Sci USA 104: 17347-52 (2007)
Article DOI: 10.1073/pnas.0707365104
BindingDB Entry DOI: 10.7270/Q26974FQ |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50134019
(CHEMBL336417 | N,N'-(9-(3-aminophenylamino)acridin...)Show SMILES Nc1cccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)c1 Show InChI InChI=1S/C33H39N7O2/c34-23-6-5-7-24(20-23)37-33-27-10-8-25(35-31(41)12-18-39-14-1-2-15-39)21-29(27)38-30-22-26(9-11-28(30)33)36-32(42)13-19-40-16-3-4-17-40/h5-11,20-22H,1-4,12-19,34H2,(H,35,41)(H,36,42)(H,37,38) | PDB
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| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Central University of Las Villas
Curated by ChEMBL
| Assay Description
Inhibition of telomerase in human A2780 cells by TRAP assay |
Eur J Med Chem 44: 4826-40 (2009)
Article DOI: 10.1016/j.ejmech.2009.07.029
BindingDB Entry DOI: 10.7270/Q20R9PHM |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50196492
(2,9-bis-[2-(2-hydroxy-ethylamino)-ethyl]-anthra[2,...)Show SMILES OCCNCCn1c(=O)c2ccc3c4ccc5c6c(ccc(c7ccc(c2c37)c1=O)c46)c(=O)n(CCNCCO)c5=O Show InChI InChI=1S/C32H28N4O6/c37-15-11-33-9-13-35-29(39)21-5-1-17-18-2-6-23-28-24(32(42)36(31(23)41)14-10-34-12-16-38)8-4-20(26(18)28)19-3-7-22(30(35)40)27(21)25(17)19/h1-8,33-34,37-38H,9-16H2 | PDB
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| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Padova
Curated by ChEMBL
| Assay Description
Inhibition of telomerase in JR8 cell extract by TRAP assay |
Bioorg Med Chem 15: 555-62 (2006)
Article DOI: 10.1016/j.bmc.2006.09.029
BindingDB Entry DOI: 10.7270/Q2QC033H |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50134018
(CHEMBL335819 | N,N'-(9-(4-aminophenylamino)acridin...)Show SMILES Nc1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)cc1 Show InChI InChI=1S/C33H39N7O2/c34-23-5-7-24(8-6-23)37-33-27-11-9-25(35-31(41)13-19-39-15-1-2-16-39)21-29(27)38-30-22-26(10-12-28(30)33)36-32(42)14-20-40-17-3-4-18-40/h5-12,21-22H,1-4,13-20,34H2,(H,35,41)(H,36,42)(H,37,38) | PDB
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| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi"Magna Gr£cia"
Curated by ChEMBL
| Assay Description
Inhibition of telomerase (unknown origin) by TRAP assay |
Eur J Med Chem 68: 139-49 (2013)
Article DOI: 10.1016/j.ejmech.2013.07.022
BindingDB Entry DOI: 10.7270/Q24J0GJB |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50107609
(5,10,15,20-tetra(1-methyl-4-pyridyl)-porphyrin | C...)Show SMILES C[n+]1ccc(cc1)-c1c2ccc(n2)c(-c2cc[n+](C)cc2)c2ccc([nH]2)c(-c2cc[n+](C)cc2)c2ccc([nH]2)c(-c2cc[n+](C)cc2)c2ccc1n2 Show InChI InChI=1S/C44H37N8/c1-49-21-13-29(14-22-49)41-33-5-7-35(45-33)42(30-15-23-50(2)24-16-30)37-9-11-39(47-37)44(32-19-27-52(4)28-20-32)40-12-10-38(48-40)43(36-8-6-34(41)46-36)31-17-25-51(3)26-18-31/h5-28H,1-4H3,(H,45,46,47,48)/q+3/p+1/b41-33-,41-34-,42-35-,42-37-,43-36-,43-38-,44-39-,44-40- | PDB
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| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description
Inhibition of telomerase in human HeLa cells using 5'-AAT CCG TCG AGC AGA GTT-3' as substrate incubated for 15 mins prior to extension reaction by te... |
J Med Chem 55: 3678-86 (2012)
Article DOI: 10.1021/jm201191d
BindingDB Entry DOI: 10.7270/Q2DF6SB3 |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50134009
(CHEMBL335132 | N,N'-(9-(3-(dimethylamino)propylami...)Show SMILES CN(C)CCCNc1c2ccc(NC(=O)CCN3CCCC3)cc2nc2cc(NC(=O)CCN3CCCC3)ccc12 Show InChI InChI=1S/C32H45N7O2/c1-37(2)15-7-14-33-32-26-10-8-24(34-30(40)12-20-38-16-3-4-17-38)22-28(26)36-29-23-25(9-11-27(29)32)35-31(41)13-21-39-18-5-6-19-39/h8-11,22-23H,3-7,12-21H2,1-2H3,(H,33,36)(H,34,40)(H,35,41) | PDB
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| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Central University of Las Villas
Curated by ChEMBL
| Assay Description
Inhibition of telomerase in human A2780 cells by TRAP assay |
Eur J Med Chem 44: 4826-40 (2009)
Article DOI: 10.1016/j.ejmech.2009.07.029
BindingDB Entry DOI: 10.7270/Q20R9PHM |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50376748
(CHEMBL259739 | Phen-DC3)Show SMILES C[n+]1cc(NC(=O)c2ccc3ccc4ccc(nc4c3n2)C(=O)Nc2c[n+](C)c3ccccc3c2)cc2ccccc12 Show InChI InChI=1S/C34H24N6O2/c1-39-19-25(17-23-7-3-5-9-29(23)39)35-33(41)27-15-13-21-11-12-22-14-16-28(38-32(22)31(21)37-27)34(42)36-26-18-24-8-4-6-10-30(24)40(2)20-26/h3-20H,1-2H3/p+2 | PDB
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| n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut National de la Sant£ et de la Recherche M£dicale
Curated by ChEMBL
| Assay Description
Inhibition of human telomerase expressed in in HEK293T cells in presence of primer (T2AG3)4 by primer extension assay |
Proc Natl Acad Sci USA 104: 17347-52 (2007)
Article DOI: 10.1073/pnas.0707365104
BindingDB Entry DOI: 10.7270/Q26974FQ |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50376747
(CHEMBL409247)Show SMILES C[n+]1cc(NC(=O)c2cccc(n2)C(=O)Nc2c[n+](C)c3ccccc3c2)cc2ccccc12 Show InChI InChI=1S/C27H21N5O2/c1-31-16-20(14-18-8-3-5-12-24(18)31)28-26(33)22-10-7-11-23(30-22)27(34)29-21-15-19-9-4-6-13-25(19)32(2)17-21/h3-17H,1-2H3/p+2 | PDB
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| n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut National de la Sant£ et de la Recherche M£dicale
Curated by ChEMBL
| Assay Description
Inhibition of human telomerase expressed in HEK293T cells treated after telomerase elongation by telomeric repeat amplification protocol assay |
Proc Natl Acad Sci USA 104: 17347-52 (2007)
Article DOI: 10.1073/pnas.0707365104
BindingDB Entry DOI: 10.7270/Q26974FQ |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50134030
(9-[4-(N,N-dimethylamino)phenylamino]-3,6-bis(3-pyr...)Show SMILES CN(C)c1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)cc1 Show InChI InChI=1S/C35H43N7O2/c1-40(2)28-11-7-25(8-12-28)38-35-29-13-9-26(36-33(43)15-21-41-17-3-4-18-41)23-31(29)39-32-24-27(10-14-30(32)35)37-34(44)16-22-42-19-5-6-20-42/h7-14,23-24H,3-6,15-22H2,1-2H3,(H,36,43)(H,37,44)(H,38,39) | PDB
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| n/a | n/a | 65 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut National de la Sant£ et de la Recherche M£dicale
Curated by ChEMBL
| Assay Description
Inhibition of human telomerase expressed in HEK293T cells treated after telomerase elongation by telomeric repeat amplification protocol assay |
Proc Natl Acad Sci USA 104: 17347-52 (2007)
Article DOI: 10.1073/pnas.0707365104
BindingDB Entry DOI: 10.7270/Q26974FQ |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50134025
(CHEMBL343795 | N,N'-(9-(4-fluorophenylamino)acridi...)Show SMILES Fc1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)cc1 Show InChI InChI=1S/C33H37FN6O2/c34-23-5-7-24(8-6-23)37-33-27-11-9-25(35-31(41)13-19-39-15-1-2-16-39)21-29(27)38-30-22-26(10-12-28(30)33)36-32(42)14-20-40-17-3-4-18-40/h5-12,21-22H,1-4,13-20H2,(H,35,41)(H,36,42)(H,37,38) | PDB
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| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Central University of Las Villas
Curated by ChEMBL
| Assay Description
Inhibition of telomerase in human A2780 cells by TRAP assay |
Eur J Med Chem 44: 4826-40 (2009)
Article DOI: 10.1016/j.ejmech.2009.07.029
BindingDB Entry DOI: 10.7270/Q20R9PHM |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50058035
(CHEMBL3330789)Show SMILES Cl.NCCCNc1c2C(=O)c3ccccc3C(=O)c2c(NCCNC(N)=N)c2ccsc12 Show InChI InChI=1S/C22H24N6O2S.ClH/c23-7-3-8-26-18-16-15(19(29)12-4-1-2-5-13(12)20(16)30)17(14-6-11-31-21(14)18)27-9-10-28-22(24)25;/h1-2,4-6,11,26-27H,3,7-10,23H2,(H4,24,25,28);1H | PDB
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| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Russian Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of human telomerase transfected in human HEK293T cells assessed as DNA extension using 5'-d(AATCCGTCGAGCAGAGTT)-3' substrate by Real-time ... |
Eur J Med Chem 85: 605-14 (2014)
Article DOI: 10.1016/j.ejmech.2014.08.030
BindingDB Entry DOI: 10.7270/Q2FX7C4Z |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50134018
(CHEMBL335819 | N,N'-(9-(4-aminophenylamino)acridin...)Show SMILES Nc1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)cc1 Show InChI InChI=1S/C33H39N7O2/c34-23-5-7-24(8-6-23)37-33-27-11-9-25(35-31(41)13-19-39-15-1-2-16-39)21-29(27)38-30-22-26(10-12-28(30)33)36-32(42)14-20-40-17-3-4-18-40/h5-12,21-22H,1-4,13-20,34H2,(H,35,41)(H,36,42)(H,37,38) | PDB
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| n/a | n/a | 74 | n/a | n/a | n/a | n/a | n/a | n/a |
Central University of Las Villas
Curated by ChEMBL
| Assay Description
Inhibition of telomerase in human A2780 cells by TRAP assay |
Eur J Med Chem 44: 4826-40 (2009)
Article DOI: 10.1016/j.ejmech.2009.07.029
BindingDB Entry DOI: 10.7270/Q20R9PHM |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50058037
(CHEMBL3330791)Show SMILES Cl.NC(=N)NCCNc1c2C(=O)c3ccccc3C(=O)c2c(NCCNC(N)=N)c2sccc12 Show InChI InChI=1S/C22H24N8O2S.ClH/c23-21(24)29-8-6-27-16-13-5-10-33-20(13)17(28-7-9-30-22(25)26)15-14(16)18(31)11-3-1-2-4-12(11)19(15)32;/h1-5,10,27-28H,6-9H2,(H4,23,24,29)(H4,25,26,30);1H | PDB
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| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Russian Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of human telomerase transfected in human HEK293T cells assessed as DNA extension using 5'-d(AATCCGTCGAGCAGAGTT)-3' substrate by Real-time ... |
Eur J Med Chem 85: 605-14 (2014)
Article DOI: 10.1016/j.ejmech.2014.08.030
BindingDB Entry DOI: 10.7270/Q2FX7C4Z |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50134008
(CHEMBL138187 | N,N'-(9-(3-(dimethylamino)propylami...)Show SMILES CN(C)CCCNc1c2ccc(NC(=O)CCN3CCCC3)cc2nc2ccc(NC(=O)CCN3CCCC3)cc12 Show InChI InChI=1S/C32H45N7O2/c1-37(2)15-7-14-33-32-26-10-8-25(35-31(41)13-21-39-18-5-6-19-39)23-29(26)36-28-11-9-24(22-27(28)32)34-30(40)12-20-38-16-3-4-17-38/h8-11,22-23H,3-7,12-21H2,1-2H3,(H,33,36)(H,34,40)(H,35,41) | PDB
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| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Central University of Las Villas
Curated by ChEMBL
| Assay Description
Inhibition of telomerase in human A2780 cells by TRAP assay |
Eur J Med Chem 44: 4826-40 (2009)
Article DOI: 10.1016/j.ejmech.2009.07.029
BindingDB Entry DOI: 10.7270/Q20R9PHM |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50134023
(CHEMBL337762 | N,N'-(9-(4-aminophenylamino)acridin...)Show SMILES Nc1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3ccc(NC(=O)CCN4CCCC4)cc23)cc1 Show InChI InChI=1S/C33H39N7O2/c34-23-5-7-24(8-6-23)37-33-27-11-9-26(36-32(42)14-20-40-17-3-4-18-40)22-30(27)38-29-12-10-25(21-28(29)33)35-31(41)13-19-39-15-1-2-16-39/h5-12,21-22H,1-4,13-20,34H2,(H,35,41)(H,36,42)(H,37,38) | PDB
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| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Central University of Las Villas
Curated by ChEMBL
| Assay Description
Inhibition of telomerase in human A2780 cells by TRAP assay |
Eur J Med Chem 44: 4826-40 (2009)
Article DOI: 10.1016/j.ejmech.2009.07.029
BindingDB Entry DOI: 10.7270/Q20R9PHM |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50150618
(CHEMBL182871 | Hexanedioic acid {4-[3,6-bis-(3-pyr...)Show SMILES CCN(CC)CCCCCCNC(=O)CCCCC(=O)Nc1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)cc1 Show InChI InChI=1S/C49H69N9O4/c1-3-56(4-2)28-10-6-5-9-27-50-45(59)15-7-8-16-46(60)51-37-17-19-38(20-18-37)54-49-41-23-21-39(52-47(61)25-33-57-29-11-12-30-57)35-43(41)55-44-36-40(22-24-42(44)49)53-48(62)26-34-58-31-13-14-32-58/h17-24,35-36H,3-16,25-34H2,1-2H3,(H,50,59)(H,51,60)(H,52,61)(H,53,62)(H,54,55) | PDB
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| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Central University of Las Villas
Curated by ChEMBL
| Assay Description
Inhibition of telomerase in human A2780 cells by TRAP assay |
Eur J Med Chem 44: 4826-40 (2009)
Article DOI: 10.1016/j.ejmech.2009.07.029
BindingDB Entry DOI: 10.7270/Q20R9PHM |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50134000
(CHEMBL139287 | N,N'-(9-(cyclohexylamino)acridine-3...)Show SMILES O=C(CCN1CCCC1)Nc1ccc2c(NC3CCCCC3)c3ccc(NC(=O)CCN4CCCC4)cc3nc2c1 Show InChI InChI=1S/C33H44N6O2/c40-31(14-20-38-16-4-5-17-38)34-25-10-12-27-29(22-25)37-30-23-26(35-32(41)15-21-39-18-6-7-19-39)11-13-28(30)33(27)36-24-8-2-1-3-9-24/h10-13,22-24H,1-9,14-21H2,(H,34,40)(H,35,41)(H,36,37) | PDB
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| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Central University of Las Villas
Curated by ChEMBL
| Assay Description
Inhibition of telomerase in human A2780 cells by TRAP assay |
Eur J Med Chem 44: 4826-40 (2009)
Article DOI: 10.1016/j.ejmech.2009.07.029
BindingDB Entry DOI: 10.7270/Q20R9PHM |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50134030
(9-[4-(N,N-dimethylamino)phenylamino]-3,6-bis(3-pyr...)Show SMILES CN(C)c1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)cc1 Show InChI InChI=1S/C35H43N7O2/c1-40(2)28-11-7-25(8-12-28)38-35-29-13-9-26(36-33(43)15-21-41-17-3-4-18-41)23-31(29)39-32-24-27(10-14-30(32)35)37-34(44)16-22-42-19-5-6-20-42/h7-14,23-24H,3-6,15-22H2,1-2H3,(H,36,43)(H,37,44)(H,38,39) | PDB
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| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Reims-Champagne-Ardenne
Curated by ChEMBL
| Assay Description
Inhibition of human telomerase in A549 cells by TRAP assay |
Eur J Med Chem 44: 3880-8 (2009)
Article DOI: 10.1016/j.ejmech.2009.04.021
BindingDB Entry DOI: 10.7270/Q2W37WDH |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50126186
(2-(3-Naphthalen-2-yl-but-2-enoylamino)-benzoic aci...)Show InChI InChI=1S/C21H17NO3/c1-14(16-11-10-15-6-2-3-7-17(15)13-16)12-20(23)22-19-9-5-4-8-18(19)21(24)25/h2-13H,1H3,(H,22,23)(H,24,25)/b14-12+ | PDB
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| n/a | n/a | 93 | n/a | n/a | n/a | n/a | n/a | n/a |
Anhui Medical University
Curated by ChEMBL
| Assay Description
Inhibition of human telomerase |
Eur J Med Chem 112: 231-51 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.009
BindingDB Entry DOI: 10.7270/Q2SB47N4 |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50126186
(2-(3-Naphthalen-2-yl-but-2-enoylamino)-benzoic aci...)Show InChI InChI=1S/C21H17NO3/c1-14(16-11-10-15-6-2-3-7-17(15)13-16)12-20(23)22-19-9-5-4-8-18(19)21(24)25/h2-13H,1H3,(H,22,23)(H,24,25)/b14-12+ | PDB
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| n/a | n/a | 93 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description
Inhibition of telomerase in human HeLa cells after 2 hrs by [alpha-32P]dGTP incorporation assay |
J Med Chem 55: 3678-86 (2012)
Article DOI: 10.1021/jm201191d
BindingDB Entry DOI: 10.7270/Q2DF6SB3 |
More data for this
Ligand-Target Pair | |
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