Found 68 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM150991
(US8987257, 4)Show SMILES C[C@H]1COCCN1c1nc(nc2[nH]c(nc12)-c1ccc(F)c(CO)c1)N1CCOCC1 |r| | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | 7.5 | 4 |
Novartis AG
US Patent
| Assay Description
PI3K KinaseGlo assay: 50 mL of compound dilutions were dispensed onto black 384-well low volume Non Binding Styrene (NBS) plates (Costar Cat. No. NBS... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM150995
(US8987257, 8)Show SMILES C1CC2CN(CC1O2)c1nc(nc2[nH]c(nc12)-c1cccc2[nH]ccc12)N1CCOCC1 Show InChI InChI=1S/C23H23N7O2/c1-2-17(16-6-7-24-18(16)3-1)20-25-19-21(26-20)27-23(29-8-10-31-11-9-29)28-22(19)30-12-14-4-5-15(13-30)32-14/h1-3,6-7,14-15H,4-5,8-13H2/b20-17- | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | >9.10E+3 | n/a | n/a | n/a | n/a | 7.5 | 4 |
Novartis AG
US Patent
| Assay Description
PI3K KinaseGlo assay: 50 mL of compound dilutions were dispensed onto black 384-well low volume Non Binding Styrene (NBS) plates (Costar Cat. No. NBS... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM150997
(US8987257, 10)Show SMILES C[C@H]1COCCN1c1nc(nc2[nH]c(nc12)-c1cc(CO)ccc1Cl)N1CCOCC1 |r| | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 720 | n/a | n/a | n/a | n/a | 7.5 | 4 |
Novartis AG
US Patent
| Assay Description
PI3K KinaseGlo assay: 50 mL of compound dilutions were dispensed onto black 384-well low volume Non Binding Styrene (NBS) plates (Costar Cat. No. NBS... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM150998
(US8987257, 11)Show SMILES NCc1cc(ccn1)-c1nc2c(nc(nc2[nH]1)N1CCOCC1)N1CCOCC1 Show InChI InChI=1S/C19H24N8O2/c20-12-14-11-13(1-2-21-14)16-22-15-17(23-16)24-19(27-5-9-29-10-6-27)25-18(15)26-3-7-28-8-4-26/h1-2,11H,3-10,12,20H2,(H,22,23,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 8.14E+3 | n/a | n/a | n/a | n/a | 7.5 | 4 |
Novartis AG
US Patent
| Assay Description
PI3K KinaseGlo assay: 50 mL of compound dilutions were dispensed onto black 384-well low volume Non Binding Styrene (NBS) plates (Costar Cat. No. NBS... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM151006
(US8987257, 19)Show SMILES C[C@@H]1COCCN1c1nc(N2CCOC[C@H]2C)c2nc([nH]c2n1)-c1cc(CO)ccc1F |r| | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | 7.5 | 4 |
Novartis AG
US Patent
| Assay Description
PI3K KinaseGlo assay: 50 mL of compound dilutions were dispensed onto black 384-well low volume Non Binding Styrene (NBS) plates (Costar Cat. No. NBS... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM151014
(US8987257, 27)Show SMILES C1CN(CCO1)c1nc(N2CCOCC2)c2nc([nH]c2n1)-c1cccc2[nH]ncc12 Show InChI InChI=1S/C20H22N8O2/c1-2-13(14-12-21-26-15(14)3-1)17-22-16-18(23-17)24-20(28-6-10-30-11-7-28)25-19(16)27-4-8-29-9-5-27/h1-3,12H,4-11H2,(H,21,26)(H,22,23,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | 7.5 | 4 |
Novartis AG
US Patent
| Assay Description
PI3K KinaseGlo assay: 50 mL of compound dilutions were dispensed onto black 384-well low volume Non Binding Styrene (NBS) plates (Costar Cat. No. NBS... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM150989
(US8987257, 2)Show SMILES Oc1cccc(c1)-c1cc2c(nc(nc2[nH]1)N1CCOCC1)N1CCOCC1 Show InChI InChI=1S/C20H23N5O3/c26-15-3-1-2-14(12-15)17-13-16-18(21-17)22-20(25-6-10-28-11-7-25)23-19(16)24-4-8-27-9-5-24/h1-3,12-13,26H,4-11H2,(H,21,22,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Novartis AG
US Patent
| Assay Description
IC50s for mTOR interacting compounds were assessed using the FRAP1/mTOR TR-FRET tracer assay (Invitrogen by Life Technologies). FRAP1/mTOR (PV4753) a... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM150992
(US8987257, 5)Show SMILES C[C@H]1COCCN1c1nc(nc2[nH]c(nc12)-c1ccnc2[nH]ccc12)N1CCC(F)(F)CC1 |r| Show InChI InChI=1S/C22H22F2N8O/c1-13-12-33-11-10-32(13)20-16-19(29-21(30-20)31-8-4-22(23,24)5-9-31)28-18(27-16)15-3-7-26-17-14(15)2-6-25-17/h2-3,6-7,13H,4-5,8-12H2,1H3/b18-15-/t13-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Novartis AG
US Patent
| Assay Description
IC50s for mTOR interacting compounds were assessed using the FRAP1/mTOR TR-FRET tracer assay (Invitrogen by Life Technologies). FRAP1/mTOR (PV4753) a... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM151000
(US8987257, 13)Show SMILES C[C@H]1COCCN1c1nc(nc2[nH]c(nc12)-c1cnc2cc[nH]c2c1)N1CCOCC1 |r| Show InChI InChI=1S/C21H22N8O2/c1-13-12-31-9-6-29(13)20-17-19(26-21(27-20)28-4-7-30-8-5-28)25-18(24-17)14-10-16-15(23-11-14)2-3-22-16/h2-3,10-11,13H,4-9,12H2,1H3/b18-14+/t13-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 469 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Novartis AG
US Patent
| Assay Description
IC50s for mTOR interacting compounds were assessed using the FRAP1/mTOR TR-FRET tracer assay (Invitrogen by Life Technologies). FRAP1/mTOR (PV4753) a... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM151003
(US8987257, 16)Show SMILES C[C@H]1COCCN1c1nc(nc2[nH]c(nc12)-c1cccc2[nH]ccc12)N1CCC(O)CC1 |r| Show InChI InChI=1S/C23H25N7O2/c1-14-13-32-12-11-30(14)22-19-21(27-23(28-22)29-9-6-15(31)7-10-29)26-20(25-19)17-3-2-4-18-16(17)5-8-24-18/h2-5,8,14-15,31H,6-7,9-13H2,1H3/b20-17-/t14-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Novartis AG
US Patent
| Assay Description
IC50s for mTOR interacting compounds were assessed using the FRAP1/mTOR TR-FRET tracer assay (Invitrogen by Life Technologies). FRAP1/mTOR (PV4753) a... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM151005
(US8987257, 18)Show SMILES C[C@@H]1COCCN1c1nc(N2CCOC[C@@H]2C)c2nc([nH]c2n1)-c1cccc2[nH]ccc12 |r| Show InChI InChI=1S/C23H25N7O2/c1-14-12-31-10-8-29(14)22-19-21(27-23(28-22)30-9-11-32-13-15(30)2)26-20(25-19)17-4-3-5-18-16(17)6-7-24-18/h3-7,14-15H,8-13H2,1-2H3/b20-17-/t14-,15+/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 46 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Novartis AG
US Patent
| Assay Description
IC50s for mTOR interacting compounds were assessed using the FRAP1/mTOR TR-FRET tracer assay (Invitrogen by Life Technologies). FRAP1/mTOR (PV4753) a... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM151013
(US8987257, 26)Show SMILES C1CN(CCO1)c1nc(N2CCOCC2)c2nc([nH]c2n1)-c1cccc2[nH]ccc12 Show InChI InChI=1S/C21H23N7O2/c1-2-15(14-4-5-22-16(14)3-1)18-23-17-19(24-18)25-21(28-8-12-30-13-9-28)26-20(17)27-6-10-29-11-7-27/h1-5,22H,6-13H2,(H,23,24,25,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Novartis AG
US Patent
| Assay Description
IC50s for mTOR interacting compounds were assessed using the FRAP1/mTOR TR-FRET tracer assay (Invitrogen by Life Technologies). FRAP1/mTOR (PV4753) a... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM151014
(US8987257, 27)Show SMILES C1CN(CCO1)c1nc(N2CCOCC2)c2nc([nH]c2n1)-c1cccc2[nH]ncc12 Show InChI InChI=1S/C20H22N8O2/c1-2-13(14-12-21-26-15(14)3-1)17-22-16-18(23-17)24-20(28-6-10-30-11-7-28)25-19(16)27-4-8-29-9-5-27/h1-3,12H,4-11H2,(H,21,26)(H,22,23,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 340 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Novartis AG
US Patent
| Assay Description
IC50s for mTOR interacting compounds were assessed using the FRAP1/mTOR TR-FRET tracer assay (Invitrogen by Life Technologies). FRAP1/mTOR (PV4753) a... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM151016
(US8987257, 29)Show SMILES Nc1cccc(c1)-c1nc2c(nc(nc2[nH]1)N1CCOCC1)N1CCOCC1 Show InChI InChI=1S/C19H23N7O2/c20-14-3-1-2-13(12-14)16-21-15-17(22-16)23-19(26-6-10-28-11-7-26)24-18(15)25-4-8-27-9-5-25/h1-3,12H,4-11,20H2,(H,21,22,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 1.21E+3 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Novartis AG
US Patent
| Assay Description
IC50s for mTOR interacting compounds were assessed using the FRAP1/mTOR TR-FRET tracer assay (Invitrogen by Life Technologies). FRAP1/mTOR (PV4753) a... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM151009
(US8987257, 22)Show SMILES C[C@H]1COCCN1c1nc(N2CCOC[C@@H]2C)c2nc([nH]c2n1)-c1cccc2[nH]ccc12 |r| Show InChI InChI=1S/C23H25N7O2/c1-14-12-31-10-8-29(14)22-19-21(27-23(28-22)30-9-11-32-13-15(30)2)26-20(25-19)17-4-3-5-18-16(17)6-7-24-18/h3-7,14-15H,8-13H2,1-2H3/b20-17-/t14-,15-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 5.86E+3 | n/a | n/a | n/a | n/a | 7.5 | 4 |
Novartis AG
US Patent
| Assay Description
PI3K KinaseGlo assay: 50 mL of compound dilutions were dispensed onto black 384-well low volume Non Binding Styrene (NBS) plates (Costar Cat. No. NBS... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM151022
(US8987257, 35)Show SMILES OCc1ccccc1-c1nc2c(nc(nc2[nH]1)N1CCOCC1)N1CCOCC1 Show InChI InChI=1S/C20H24N6O3/c27-13-14-3-1-2-4-15(14)17-21-16-18(22-17)23-20(26-7-11-29-12-8-26)24-19(16)25-5-9-28-10-6-25/h1-4,27H,5-13H2,(H,21,22,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 5.87E+3 | n/a | n/a | n/a | n/a | 7.5 | 4 |
Novartis AG
US Patent
| Assay Description
PI3K KinaseGlo assay: 50 mL of compound dilutions were dispensed onto black 384-well low volume Non Binding Styrene (NBS) plates (Costar Cat. No. NBS... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM150989
(US8987257, 2)Show SMILES Oc1cccc(c1)-c1cc2c(nc(nc2[nH]1)N1CCOCC1)N1CCOCC1 Show InChI InChI=1S/C20H23N5O3/c26-15-3-1-2-14(12-15)17-13-16-18(21-17)22-20(25-6-10-28-11-7-25)23-19(16)24-4-8-27-9-5-24/h1-3,12-13,26H,4-11H2,(H,21,22,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 1.06E+3 | n/a | n/a | n/a | n/a | 7.5 | 4 |
Novartis AG
US Patent
| Assay Description
PI3K KinaseGlo assay: 50 mL of compound dilutions were dispensed onto black 384-well low volume Non Binding Styrene (NBS) plates (Costar Cat. No. NBS... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM151016
(US8987257, 29)Show SMILES Nc1cccc(c1)-c1nc2c(nc(nc2[nH]1)N1CCOCC1)N1CCOCC1 Show InChI InChI=1S/C19H23N7O2/c20-14-3-1-2-13(12-14)16-21-15-17(22-16)23-19(26-6-10-28-11-7-26)24-18(15)25-4-8-27-9-5-25/h1-3,12H,4-11,20H2,(H,21,22,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 3.86E+3 | n/a | n/a | n/a | n/a | 7.5 | 4 |
Novartis AG
US Patent
| Assay Description
PI3K KinaseGlo assay: 50 mL of compound dilutions were dispensed onto black 384-well low volume Non Binding Styrene (NBS) plates (Costar Cat. No. NBS... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM151021
(US8987257, 34)Show SMILES C[C@H]1CN(C[C@@H](C)O1)c1nc(N2CCOCC2)c2nc([nH]c2n1)-c1ccccc1CO |r| | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | >9.10E+3 | n/a | n/a | n/a | n/a | 7.5 | 4 |
Novartis AG
US Patent
| Assay Description
PI3K KinaseGlo assay: 50 mL of compound dilutions were dispensed onto black 384-well low volume Non Binding Styrene (NBS) plates (Costar Cat. No. NBS... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM151010
(US8987257, 23)Show SMILES C[C@H]1COCCN1c1nc(nc2[nH]c(nc12)-c1cccc2[nH]ccc12)N1CCOCC1 |r| Show InChI InChI=1S/C22H23N7O2/c1-14-13-31-12-9-29(14)21-18-20(26-22(27-21)28-7-10-30-11-8-28)25-19(24-18)16-3-2-4-17-15(16)5-6-23-17/h2-6,14H,7-13H2,1H3/b19-16-/t14-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Novartis AG
US Patent
| Assay Description
IC50s for mTOR interacting compounds were assessed using the FRAP1/mTOR TR-FRET tracer assay (Invitrogen by Life Technologies). FRAP1/mTOR (PV4753) a... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM151011
(US8987257, 24)Show SMILES C[C@H]1COCCN1c1nc(nc2[nH]c(nc12)-c1ccc2cc[nH]c2c1)N1CCOCC1 |r| Show InChI InChI=1S/C22H23N7O2/c1-14-13-31-11-8-29(14)21-18-20(26-22(27-21)28-6-9-30-10-7-28)25-19(24-18)16-3-2-15-4-5-23-17(15)12-16/h2-5,12,14H,6-11,13H2,1H3/b19-16-/t14-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 8.54E+3 | n/a | n/a | n/a | n/a | 7.5 | 4 |
Novartis AG
US Patent
| Assay Description
PI3K KinaseGlo assay: 50 mL of compound dilutions were dispensed onto black 384-well low volume Non Binding Styrene (NBS) plates (Costar Cat. No. NBS... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM151015
(US8987257, 28)Show SMILES C1CN(CCO1)c1nc(N2CCOCC2)c2nc([nH]c2n1)-c1ccc2cc[nH]c2c1 Show InChI InChI=1S/C21H23N7O2/c1-2-15(13-16-14(1)3-4-22-16)18-23-17-19(24-18)25-21(28-7-11-30-12-8-28)26-20(17)27-5-9-29-10-6-27/h1-4,13,22H,5-12H2,(H,23,24,25,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 9.05E+3 | n/a | n/a | n/a | n/a | 7.5 | 4 |
Novartis AG
US Patent
| Assay Description
PI3K KinaseGlo assay: 50 mL of compound dilutions were dispensed onto black 384-well low volume Non Binding Styrene (NBS) plates (Costar Cat. No. NBS... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM151020
(US8987257, 33)Show SMILES CS(=O)(=O)Nc1cccc(c1)-c1nc2c(nc(nc2[nH]1)N1CCOCC1)N1CCOCC1 Show InChI InChI=1S/C20H25N7O4S/c1-32(28,29)25-15-4-2-3-14(13-15)17-21-16-18(22-17)23-20(27-7-11-31-12-8-27)24-19(16)26-5-9-30-10-6-26/h2-4,13,25H,5-12H2,1H3,(H,21,22,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | >9.10E+3 | n/a | n/a | n/a | n/a | 7.5 | 4 |
Novartis AG
US Patent
| Assay Description
PI3K KinaseGlo assay: 50 mL of compound dilutions were dispensed onto black 384-well low volume Non Binding Styrene (NBS) plates (Costar Cat. No. NBS... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM151024
(US8987257, 37)Show SMILES OCc1cccc(c1)-c1nc2c(nc(nc2[nH]1)N1CCOCC1)N1CCOCC1 Show InChI InChI=1S/C20H24N6O3/c27-13-14-2-1-3-15(12-14)17-21-16-18(22-17)23-20(26-6-10-29-11-7-26)24-19(16)25-4-8-28-9-5-25/h1-3,12,27H,4-11,13H2,(H,21,22,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | 7.5 | 4 |
Novartis AG
US Patent
| Assay Description
PI3K KinaseGlo assay: 50 mL of compound dilutions were dispensed onto black 384-well low volume Non Binding Styrene (NBS) plates (Costar Cat. No. NBS... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM150988
(US8987257, 1)Show SMILES C[C@H]1CN(C[C@@H](C)O1)c1nc(N2CCOCC2)c2nc([nH]c2n1)-c1cccc(O)c1 |r| | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | 7.5 | 4 |
Novartis AG
US Patent
| Assay Description
PI3K KinaseGlo assay: 50 mL of compound dilutions were dispensed onto black 384-well low volume Non Binding Styrene (NBS) plates (Costar Cat. No. NBS... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM150992
(US8987257, 5)Show SMILES C[C@H]1COCCN1c1nc(nc2[nH]c(nc12)-c1ccnc2[nH]ccc12)N1CCC(F)(F)CC1 |r| Show InChI InChI=1S/C22H22F2N8O/c1-13-12-33-11-10-32(13)20-16-19(29-21(30-20)31-8-4-22(23,24)5-9-31)28-18(27-16)15-3-7-26-17-14(15)2-6-25-17/h2-3,6-7,13H,4-5,8-12H2,1H3/b18-15-/t13-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | >9.10E+3 | n/a | n/a | n/a | n/a | 7.5 | 4 |
Novartis AG
US Patent
| Assay Description
PI3K KinaseGlo assay: 50 mL of compound dilutions were dispensed onto black 384-well low volume Non Binding Styrene (NBS) plates (Costar Cat. No. NBS... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM150999
(US8987257, 12)Show SMILES CC(O)c1cc(ccn1)-c1nc2c(nc(nc2[nH]1)N1CCOCC1)N1CCOC[C@@H]1C |r| | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2.87E+3 | n/a | n/a | n/a | n/a | 7.5 | 4 |
Novartis AG
US Patent
| Assay Description
PI3K KinaseGlo assay: 50 mL of compound dilutions were dispensed onto black 384-well low volume Non Binding Styrene (NBS) plates (Costar Cat. No. NBS... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM151002
(US8987257, 15)Show SMILES C[C@@H]1COCCN1c1nc(N2CCOC[C@H]2C)c2nc([nH]c2n1)-c1cccc2[nH]ccc12 |r| Show InChI InChI=1S/C23H25N7O2/c1-14-12-31-10-8-29(14)22-19-21(27-23(28-22)30-9-11-32-13-15(30)2)26-20(25-19)17-4-3-5-18-16(17)6-7-24-18/h3-7,14-15H,8-13H2,1-2H3/b20-17-/t14-,15-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Novartis AG
US Patent
| Assay Description
IC50s for mTOR interacting compounds were assessed using the FRAP1/mTOR TR-FRET tracer assay (Invitrogen by Life Technologies). FRAP1/mTOR (PV4753) a... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM151011
(US8987257, 24)Show SMILES C[C@H]1COCCN1c1nc(nc2[nH]c(nc12)-c1ccc2cc[nH]c2c1)N1CCOCC1 |r| Show InChI InChI=1S/C22H23N7O2/c1-14-13-31-11-8-29(14)21-18-20(26-22(27-21)28-6-9-30-10-7-28)25-19(24-18)16-3-2-15-4-5-23-17(15)12-16/h2-5,12,14H,6-11,13H2,1H3/b19-16-/t14-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 85 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Novartis AG
US Patent
| Assay Description
IC50s for mTOR interacting compounds were assessed using the FRAP1/mTOR TR-FRET tracer assay (Invitrogen by Life Technologies). FRAP1/mTOR (PV4753) a... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM151013
(US8987257, 26)Show SMILES C1CN(CCO1)c1nc(N2CCOCC2)c2nc([nH]c2n1)-c1cccc2[nH]ccc12 Show InChI InChI=1S/C21H23N7O2/c1-2-15(14-4-5-22-16(14)3-1)18-23-17-19(24-18)25-21(28-8-12-30-13-9-28)26-20(17)27-6-10-29-11-7-27/h1-5,22H,6-13H2,(H,23,24,25,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 570 | n/a | n/a | n/a | n/a | 7.5 | 4 |
Novartis AG
US Patent
| Assay Description
PI3K KinaseGlo assay: 50 mL of compound dilutions were dispensed onto black 384-well low volume Non Binding Styrene (NBS) plates (Costar Cat. No. NBS... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM151001
(US8987257, 14)Show SMILES C[C@H]1COCCN1c1nc(N2CCOC[C@@H]2C)c2nc([nH]c2n1)-c1ccc2cc[nH]c2c1 |r| Show InChI InChI=1S/C23H25N7O2/c1-14-12-31-9-7-29(14)22-19-21(27-23(28-22)30-8-10-32-13-15(30)2)26-20(25-19)17-4-3-16-5-6-24-18(16)11-17/h3-6,11,14-15H,7-10,12-13H2,1-2H3/b20-17-/t14-,15-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | >9.10E+3 | n/a | n/a | n/a | n/a | 7.5 | 4 |
Novartis AG
US Patent
| Assay Description
PI3K KinaseGlo assay: 50 mL of compound dilutions were dispensed onto black 384-well low volume Non Binding Styrene (NBS) plates (Costar Cat. No. NBS... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM151010
(US8987257, 23)Show SMILES C[C@H]1COCCN1c1nc(nc2[nH]c(nc12)-c1cccc2[nH]ccc12)N1CCOCC1 |r| Show InChI InChI=1S/C22H23N7O2/c1-14-13-31-12-9-29(14)21-18-20(26-22(27-21)28-7-10-30-11-8-28)25-19(24-18)16-3-2-4-17-15(16)5-6-23-17/h2-6,14H,7-13H2,1H3/b19-16-/t14-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 5.51E+3 | n/a | n/a | n/a | n/a | 7.5 | 4 |
Novartis AG
US Patent
| Assay Description
PI3K KinaseGlo assay: 50 mL of compound dilutions were dispensed onto black 384-well low volume Non Binding Styrene (NBS) plates (Costar Cat. No. NBS... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM151012
(US8987257, 25)Show SMILES COC1CCN(CC1)c1nc(N2CCOCC2)c2nc([nH]c2n1)-c1cccc2[nH]ccc12 Show InChI InChI=1S/C23H27N7O2/c1-31-15-6-9-30(10-7-15)23-27-21-19(22(28-23)29-11-13-32-14-12-29)25-20(26-21)17-3-2-4-18-16(17)5-8-24-18/h2-5,8,15,24H,6-7,9-14H2,1H3,(H,25,26,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2.07E+3 | n/a | n/a | n/a | n/a | 7.5 | 4 |
Novartis AG
US Patent
| Assay Description
PI3K KinaseGlo assay: 50 mL of compound dilutions were dispensed onto black 384-well low volume Non Binding Styrene (NBS) plates (Costar Cat. No. NBS... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM151025
(US8987257, 38)Show SMILES Oc1ccccc1-c1nc2c(nc(nc2[nH]1)N1CCOCC1)N1CCOCC1 Show InChI InChI=1S/C19H22N6O3/c26-14-4-2-1-3-13(14)16-20-15-17(21-16)22-19(25-7-11-28-12-8-25)23-18(15)24-5-9-27-10-6-24/h1-4,26H,5-12H2,(H,20,21,22,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 480 | n/a | n/a | n/a | n/a | 7.5 | 4 |
Novartis AG
US Patent
| Assay Description
PI3K KinaseGlo assay: 50 mL of compound dilutions were dispensed onto black 384-well low volume Non Binding Styrene (NBS) plates (Costar Cat. No. NBS... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM151008
(US8987257, 21)Show SMILES C[C@@H]1COCCN1c1nc(nc2[nH]c(nc12)-c1ccc2cc[nH]c2c1)N1CCOCC1 |r| Show InChI InChI=1S/C22H23N7O2/c1-14-13-31-11-8-29(14)21-18-20(26-22(27-21)28-6-9-30-10-7-28)25-19(24-18)16-3-2-15-4-5-23-17(15)12-16/h2-5,12,14H,6-11,13H2,1H3/b19-16+/t14-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 237 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Novartis AG
US Patent
| Assay Description
IC50s for mTOR interacting compounds were assessed using the FRAP1/mTOR TR-FRET tracer assay (Invitrogen by Life Technologies). FRAP1/mTOR (PV4753) a... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM151009
(US8987257, 22)Show SMILES C[C@H]1COCCN1c1nc(N2CCOC[C@@H]2C)c2nc([nH]c2n1)-c1cccc2[nH]ccc12 |r| Show InChI InChI=1S/C23H25N7O2/c1-14-12-31-10-8-29(14)22-19-21(27-23(28-22)30-9-11-32-13-15(30)2)26-20(25-19)17-4-3-5-18-16(17)6-7-24-18/h3-7,14-15H,8-13H2,1-2H3/b20-17-/t14-,15-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Novartis AG
US Patent
| Assay Description
IC50s for mTOR interacting compounds were assessed using the FRAP1/mTOR TR-FRET tracer assay (Invitrogen by Life Technologies). FRAP1/mTOR (PV4753) a... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM151020
(US8987257, 33)Show SMILES CS(=O)(=O)Nc1cccc(c1)-c1nc2c(nc(nc2[nH]1)N1CCOCC1)N1CCOCC1 Show InChI InChI=1S/C20H25N7O4S/c1-32(28,29)25-15-4-2-3-14(13-15)17-21-16-18(22-17)23-20(27-7-11-31-12-8-27)24-19(16)26-5-9-30-10-6-26/h2-4,13,25H,5-12H2,1H3,(H,21,22,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 380 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Novartis AG
US Patent
| Assay Description
IC50s for mTOR interacting compounds were assessed using the FRAP1/mTOR TR-FRET tracer assay (Invitrogen by Life Technologies). FRAP1/mTOR (PV4753) a... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM151007
(US8987257, 20)Show SMILES C[C@@H]1COCCN1c1nc(nc2[nH]c(nc12)-c1cccc2[nH]ccc12)N1CCOCC1 |r| Show InChI InChI=1S/C22H23N7O2/c1-14-13-31-12-9-29(14)21-18-20(26-22(27-21)28-7-10-30-11-8-28)25-19(24-18)16-3-2-4-17-15(16)5-6-23-17/h2-6,14H,7-13H2,1H3/b19-16-/t14-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 6.05E+3 | n/a | n/a | n/a | n/a | 7.5 | 4 |
Novartis AG
US Patent
| Assay Description
PI3K KinaseGlo assay: 50 mL of compound dilutions were dispensed onto black 384-well low volume Non Binding Styrene (NBS) plates (Costar Cat. No. NBS... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM151018
(US8987257, 31)Show SMILES Cc1cc2c(cccc2[nH]1)-c1nc2c(nc(nc2[nH]1)N1CCOCC1)N1CCOCC1 Show InChI InChI=1S/C22H25N7O2/c1-14-13-16-15(3-2-4-17(16)23-14)19-24-18-20(25-19)26-22(29-7-11-31-12-8-29)27-21(18)28-5-9-30-10-6-28/h2-4,13,23H,5-12H2,1H3,(H,24,25,26,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 590 | n/a | n/a | n/a | n/a | 7.5 | 4 |
Novartis AG
US Patent
| Assay Description
PI3K KinaseGlo assay: 50 mL of compound dilutions were dispensed onto black 384-well low volume Non Binding Styrene (NBS) plates (Costar Cat. No. NBS... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM151017
(US8987257, 30)Show SMILES CC(=O)Nc1cccc(c1)-c1nc2c(nc(nc2[nH]1)N1CCOCC1)N1CCOCC1 Show InChI InChI=1S/C21H25N7O3/c1-14(29)22-16-4-2-3-15(13-16)18-23-17-19(24-18)25-21(28-7-11-31-12-8-28)26-20(17)27-5-9-30-10-6-27/h2-4,13H,5-12H2,1H3,(H,22,29)(H,23,24,25,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 3.01E+3 | n/a | n/a | n/a | n/a | 7.5 | 4 |
Novartis AG
US Patent
| Assay Description
PI3K KinaseGlo assay: 50 mL of compound dilutions were dispensed onto black 384-well low volume Non Binding Styrene (NBS) plates (Costar Cat. No. NBS... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM151019
(US8987257, 32)Show SMILES C[C@H]1CN(C[C@@H](C)O1)c1nc(N2CCOCC2)c2nc([nH]c2n1)-c1cccc(N)c1 |r| | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2.52E+3 | n/a | n/a | n/a | n/a | 7.5 | 4 |
Novartis AG
US Patent
| Assay Description
PI3K KinaseGlo assay: 50 mL of compound dilutions were dispensed onto black 384-well low volume Non Binding Styrene (NBS) plates (Costar Cat. No. NBS... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM151023
(US8987257, 36)Show SMILES Oc1cccc(c1)-c1nc2c(nc(nc2[nH]1)N1CCOCC1)N1CCOCC1 Show InChI InChI=1S/C19H22N6O3/c26-14-3-1-2-13(12-14)16-20-15-17(21-16)22-19(25-6-10-28-11-7-25)23-18(15)24-4-8-27-9-5-24/h1-3,12,26H,4-11H2,(H,20,21,22,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | 7.5 | 4 |
Novartis AG
US Patent
| Assay Description
PI3K KinaseGlo assay: 50 mL of compound dilutions were dispensed onto black 384-well low volume Non Binding Styrene (NBS) plates (Costar Cat. No. NBS... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM150997
(US8987257, 10)Show SMILES C[C@H]1COCCN1c1nc(nc2[nH]c(nc12)-c1cc(CO)ccc1Cl)N1CCOCC1 |r| | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 1.84E+3 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Novartis AG
US Patent
| Assay Description
IC50s for mTOR interacting compounds were assessed using the FRAP1/mTOR TR-FRET tracer assay (Invitrogen by Life Technologies). FRAP1/mTOR (PV4753) a... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM151004
(US8987257, 17)Show SMILES COc1cc(CO)cc(c1)-c1nc2c(nc(nc2[nH]1)N1CCOC[C@@H]1C)N1CCOC[C@@H]1C |r| | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 399 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Novartis AG
US Patent
| Assay Description
IC50s for mTOR interacting compounds were assessed using the FRAP1/mTOR TR-FRET tracer assay (Invitrogen by Life Technologies). FRAP1/mTOR (PV4753) a... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM151006
(US8987257, 19)Show SMILES C[C@@H]1COCCN1c1nc(N2CCOC[C@H]2C)c2nc([nH]c2n1)-c1cc(CO)ccc1F |r| | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 134 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Novartis AG
US Patent
| Assay Description
IC50s for mTOR interacting compounds were assessed using the FRAP1/mTOR TR-FRET tracer assay (Invitrogen by Life Technologies). FRAP1/mTOR (PV4753) a... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM151012
(US8987257, 25)Show SMILES COC1CCN(CC1)c1nc(N2CCOCC2)c2nc([nH]c2n1)-c1cccc2[nH]ccc12 Show InChI InChI=1S/C23H27N7O2/c1-31-15-6-9-30(10-7-15)23-27-21-19(22(28-23)29-11-13-32-14-12-29)25-20(26-21)17-3-2-4-18-16(17)5-8-24-18/h2-5,8,15,24H,6-7,9-14H2,1H3,(H,25,26,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 172 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Novartis AG
US Patent
| Assay Description
IC50s for mTOR interacting compounds were assessed using the FRAP1/mTOR TR-FRET tracer assay (Invitrogen by Life Technologies). FRAP1/mTOR (PV4753) a... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM150990
(US8987257, 3)Show SMILES C[C@H]1COCCN1c1nc(N2CCOC[C@@H]2C)c2nc([nH]c2n1)-c1ccnc2[nH]ccc12 |r| Show InChI InChI=1S/C22H24N8O2/c1-13-11-31-9-7-29(13)21-17-20(27-22(28-21)30-8-10-32-12-14(30)2)26-19(25-17)16-4-6-24-18-15(16)3-5-23-18/h3-6,13-14H,7-12H2,1-2H3/b19-16-/t13-,14-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 6.53E+3 | n/a | n/a | n/a | n/a | 7.5 | 4 |
Novartis AG
US Patent
| Assay Description
PI3K KinaseGlo assay: 50 mL of compound dilutions were dispensed onto black 384-well low volume Non Binding Styrene (NBS) plates (Costar Cat. No. NBS... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM150993
(US8987257, 6)Show SMILES C[C@H]1COCCN1c1nc(N2CCOC[C@@H]2C)c2nc([nH]c2n1)-c1ccc2[nH]c(=O)[nH]c2c1 |r| | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | >9.10E+3 | n/a | n/a | n/a | n/a | 7.5 | 4 |
Novartis AG
US Patent
| Assay Description
PI3K KinaseGlo assay: 50 mL of compound dilutions were dispensed onto black 384-well low volume Non Binding Styrene (NBS) plates (Costar Cat. No. NBS... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM151008
(US8987257, 21)Show SMILES C[C@@H]1COCCN1c1nc(nc2[nH]c(nc12)-c1ccc2cc[nH]c2c1)N1CCOCC1 |r| Show InChI InChI=1S/C22H23N7O2/c1-14-13-31-11-8-29(14)21-18-20(26-22(27-21)28-6-9-30-10-7-28)25-19(24-18)16-3-2-15-4-5-23-17(15)12-16/h2-5,12,14H,6-11,13H2,1H3/b19-16+/t14-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | >9.10E+3 | n/a | n/a | n/a | n/a | 7.5 | 4 |
Novartis AG
US Patent
| Assay Description
PI3K KinaseGlo assay: 50 mL of compound dilutions were dispensed onto black 384-well low volume Non Binding Styrene (NBS) plates (Costar Cat. No. NBS... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM150995
(US8987257, 8)Show SMILES C1CC2CN(CC1O2)c1nc(nc2[nH]c(nc12)-c1cccc2[nH]ccc12)N1CCOCC1 Show InChI InChI=1S/C23H23N7O2/c1-2-17(16-6-7-24-18(16)3-1)20-25-19-21(26-20)27-23(29-8-10-31-11-9-29)28-22(19)30-12-14-4-5-15(13-30)32-14/h1-3,6-7,14-15H,4-5,8-13H2/b20-17- | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 41 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Novartis AG
US Patent
| Assay Description
IC50s for mTOR interacting compounds were assessed using the FRAP1/mTOR TR-FRET tracer assay (Invitrogen by Life Technologies). FRAP1/mTOR (PV4753) a... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM150996
(US8987257, 9)Show SMILES COc1ccc(cc1C(O)=O)-c1nc2c(nc(nc2[nH]1)N1CCOCC1)N1CCOC[C@@H]1C |r| | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | >9.10E+3 | n/a | n/a | n/a | n/a | 7.5 | 4 |
Novartis AG
US Patent
| Assay Description
PI3K KinaseGlo assay: 50 mL of compound dilutions were dispensed onto black 384-well low volume Non Binding Styrene (NBS) plates (Costar Cat. No. NBS... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM150990
(US8987257, 3)Show SMILES C[C@H]1COCCN1c1nc(N2CCOC[C@@H]2C)c2nc([nH]c2n1)-c1ccnc2[nH]ccc12 |r| Show InChI InChI=1S/C22H24N8O2/c1-13-11-31-9-7-29(13)21-17-20(27-22(28-21)30-8-10-32-12-14(30)2)26-19(25-17)16-4-6-24-18-15(16)3-5-23-18/h3-6,13-14H,7-12H2,1-2H3/b19-16-/t13-,14-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 510 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Novartis AG
US Patent
| Assay Description
IC50s for mTOR interacting compounds were assessed using the FRAP1/mTOR TR-FRET tracer assay (Invitrogen by Life Technologies). FRAP1/mTOR (PV4753) a... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM150999
(US8987257, 12)Show SMILES CC(O)c1cc(ccn1)-c1nc2c(nc(nc2[nH]1)N1CCOCC1)N1CCOC[C@@H]1C |r| | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2.02E+3 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Novartis AG
US Patent
| Assay Description
IC50s for mTOR interacting compounds were assessed using the FRAP1/mTOR TR-FRET tracer assay (Invitrogen by Life Technologies). FRAP1/mTOR (PV4753) a... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM151017
(US8987257, 30)Show SMILES CC(=O)Nc1cccc(c1)-c1nc2c(nc(nc2[nH]1)N1CCOCC1)N1CCOCC1 Show InChI InChI=1S/C21H25N7O3/c1-14(29)22-16-4-2-3-15(13-16)18-23-17-19(24-18)25-21(28-7-11-31-12-8-28)26-20(17)27-5-9-30-10-6-27/h2-4,13H,5-12H2,1H3,(H,22,29)(H,23,24,25,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 1.45E+3 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Novartis AG
US Patent
| Assay Description
IC50s for mTOR interacting compounds were assessed using the FRAP1/mTOR TR-FRET tracer assay (Invitrogen by Life Technologies). FRAP1/mTOR (PV4753) a... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM151019
(US8987257, 32)Show SMILES C[C@H]1CN(C[C@@H](C)O1)c1nc(N2CCOCC2)c2nc([nH]c2n1)-c1cccc(N)c1 |r| | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 1.04E+3 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Novartis AG
US Patent
| Assay Description
IC50s for mTOR interacting compounds were assessed using the FRAP1/mTOR TR-FRET tracer assay (Invitrogen by Life Technologies). FRAP1/mTOR (PV4753) a... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM151002
(US8987257, 15)Show SMILES C[C@@H]1COCCN1c1nc(N2CCOC[C@H]2C)c2nc([nH]c2n1)-c1cccc2[nH]ccc12 |r| Show InChI InChI=1S/C23H25N7O2/c1-14-12-31-10-8-29(14)22-19-21(27-23(28-22)30-9-11-32-13-15(30)2)26-20(25-19)17-4-3-5-18-16(17)6-7-24-18/h3-7,14-15H,8-13H2,1-2H3/b20-17-/t14-,15-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 4.58E+3 | n/a | n/a | n/a | n/a | 7.5 | 4 |
Novartis AG
US Patent
| Assay Description
PI3K KinaseGlo assay: 50 mL of compound dilutions were dispensed onto black 384-well low volume Non Binding Styrene (NBS) plates (Costar Cat. No. NBS... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM150994
(US8987257, 7)Show SMILES COc1ccc(cc1CO)-c1nc2c(nc(nc2[nH]1)N1CCOC[C@@H]1C)N1CCOC[C@@H]1C |r| | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2.54E+3 | n/a | n/a | n/a | n/a | 7.5 | 4 |
Novartis AG
US Patent
| Assay Description
PI3K KinaseGlo assay: 50 mL of compound dilutions were dispensed onto black 384-well low volume Non Binding Styrene (NBS) plates (Costar Cat. No. NBS... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM151000
(US8987257, 13)Show SMILES C[C@H]1COCCN1c1nc(nc2[nH]c(nc12)-c1cnc2cc[nH]c2c1)N1CCOCC1 |r| Show InChI InChI=1S/C21H22N8O2/c1-13-12-31-9-6-29(13)20-17-19(26-21(27-20)28-4-7-30-8-5-28)25-18(24-17)14-10-16-15(23-11-14)2-3-22-16/h2-3,10-11,13H,4-9,12H2,1H3/b18-14+/t13-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 430 | n/a | n/a | n/a | n/a | 7.5 | 4 |
Novartis AG
US Patent
| Assay Description
PI3K KinaseGlo assay: 50 mL of compound dilutions were dispensed onto black 384-well low volume Non Binding Styrene (NBS) plates (Costar Cat. No. NBS... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM151003
(US8987257, 16)Show SMILES C[C@H]1COCCN1c1nc(nc2[nH]c(nc12)-c1cccc2[nH]ccc12)N1CCC(O)CC1 |r| Show InChI InChI=1S/C23H25N7O2/c1-14-13-32-12-11-30(14)22-19-21(27-23(28-22)29-9-6-15(31)7-10-29)26-20(25-19)17-3-2-4-18-16(17)5-8-24-18/h2-5,8,14-15,31H,6-7,9-13H2,1H3/b20-17-/t14-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 7.30E+3 | n/a | n/a | n/a | n/a | 7.5 | 4 |
Novartis AG
US Patent
| Assay Description
PI3K KinaseGlo assay: 50 mL of compound dilutions were dispensed onto black 384-well low volume Non Binding Styrene (NBS) plates (Costar Cat. No. NBS... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM151004
(US8987257, 17)Show SMILES COc1cc(CO)cc(c1)-c1nc2c(nc(nc2[nH]1)N1CCOC[C@@H]1C)N1CCOC[C@@H]1C |r| | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | 7.5 | 4 |
Novartis AG
US Patent
| Assay Description
PI3K KinaseGlo assay: 50 mL of compound dilutions were dispensed onto black 384-well low volume Non Binding Styrene (NBS) plates (Costar Cat. No. NBS... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM150991
(US8987257, 4)Show SMILES C[C@H]1COCCN1c1nc(nc2[nH]c(nc12)-c1ccc(F)c(CO)c1)N1CCOCC1 |r| | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 1.42E+3 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Novartis AG
US Patent
| Assay Description
IC50s for mTOR interacting compounds were assessed using the FRAP1/mTOR TR-FRET tracer assay (Invitrogen by Life Technologies). FRAP1/mTOR (PV4753) a... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM150993
(US8987257, 6)Show SMILES C[C@H]1COCCN1c1nc(N2CCOC[C@@H]2C)c2nc([nH]c2n1)-c1ccc2[nH]c(=O)[nH]c2c1 |r| | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Novartis AG
US Patent
| Assay Description
IC50s for mTOR interacting compounds were assessed using the FRAP1/mTOR TR-FRET tracer assay (Invitrogen by Life Technologies). FRAP1/mTOR (PV4753) a... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM150996
(US8987257, 9)Show SMILES COc1ccc(cc1C(O)=O)-c1nc2c(nc(nc2[nH]1)N1CCOCC1)N1CCOC[C@@H]1C |r| | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Novartis AG
US Patent
| Assay Description
IC50s for mTOR interacting compounds were assessed using the FRAP1/mTOR TR-FRET tracer assay (Invitrogen by Life Technologies). FRAP1/mTOR (PV4753) a... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM150998
(US8987257, 11)Show SMILES NCc1cc(ccn1)-c1nc2c(nc(nc2[nH]1)N1CCOCC1)N1CCOCC1 Show InChI InChI=1S/C19H24N8O2/c20-12-14-11-13(1-2-21-14)16-22-15-17(23-16)24-19(27-5-9-29-10-6-27)25-18(15)26-3-7-28-8-4-26/h1-2,11H,3-10,12,20H2,(H,22,23,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2.43E+3 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Novartis AG
US Patent
| Assay Description
IC50s for mTOR interacting compounds were assessed using the FRAP1/mTOR TR-FRET tracer assay (Invitrogen by Life Technologies). FRAP1/mTOR (PV4753) a... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM151001
(US8987257, 14)Show SMILES C[C@H]1COCCN1c1nc(N2CCOC[C@@H]2C)c2nc([nH]c2n1)-c1ccc2cc[nH]c2c1 |r| Show InChI InChI=1S/C23H25N7O2/c1-14-12-31-9-7-29(14)22-19-21(27-23(28-22)30-8-10-32-13-15(30)2)26-20(25-19)17-4-3-16-5-6-24-18(16)11-17/h3-6,11,14-15H,7-10,12-13H2,1-2H3/b20-17-/t14-,15-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Novartis AG
US Patent
| Assay Description
IC50s for mTOR interacting compounds were assessed using the FRAP1/mTOR TR-FRET tracer assay (Invitrogen by Life Technologies). FRAP1/mTOR (PV4753) a... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM151007
(US8987257, 20)Show SMILES C[C@@H]1COCCN1c1nc(nc2[nH]c(nc12)-c1cccc2[nH]ccc12)N1CCOCC1 |r| Show InChI InChI=1S/C22H23N7O2/c1-14-13-31-12-9-29(14)21-18-20(26-22(27-21)28-7-10-30-11-8-28)25-19(24-18)16-3-2-4-17-15(16)5-6-23-17/h2-6,14H,7-13H2,1H3/b19-16-/t14-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Novartis AG
US Patent
| Assay Description
IC50s for mTOR interacting compounds were assessed using the FRAP1/mTOR TR-FRET tracer assay (Invitrogen by Life Technologies). FRAP1/mTOR (PV4753) a... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM151015
(US8987257, 28)Show SMILES C1CN(CCO1)c1nc(N2CCOCC2)c2nc([nH]c2n1)-c1ccc2cc[nH]c2c1 Show InChI InChI=1S/C21H23N7O2/c1-2-15(13-16-14(1)3-4-22-16)18-23-17-19(24-18)25-21(28-7-11-30-12-8-28)26-20(17)27-5-9-29-10-6-27/h1-4,13,22H,5-12H2,(H,23,24,25,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 372 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Novartis AG
US Patent
| Assay Description
IC50s for mTOR interacting compounds were assessed using the FRAP1/mTOR TR-FRET tracer assay (Invitrogen by Life Technologies). FRAP1/mTOR (PV4753) a... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM151005
(US8987257, 18)Show SMILES C[C@@H]1COCCN1c1nc(N2CCOC[C@@H]2C)c2nc([nH]c2n1)-c1cccc2[nH]ccc12 |r| Show InChI InChI=1S/C23H25N7O2/c1-14-12-31-10-8-29(14)22-19-21(27-23(28-22)30-9-11-32-13-15(30)2)26-20(25-19)17-4-3-5-18-16(17)6-7-24-18/h3-7,14-15H,8-13H2,1-2H3/b20-17-/t14-,15+/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 5.05E+3 | n/a | n/a | n/a | n/a | 7.5 | 4 |
Novartis AG
US Patent
| Assay Description
PI3K KinaseGlo assay: 50 mL of compound dilutions were dispensed onto black 384-well low volume Non Binding Styrene (NBS) plates (Costar Cat. No. NBS... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this
Ligand-Target Pair | |
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