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PubMed code 22497760

Compile data set for download or QSAR
Found 144 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50381945
PNG
(CHEMBL2023477)
Show SMILES COc1cc(Oc2ccnc3cc(OC)c(OC)cc23)ccc1CC(=O)Nc1noc(C)c1C
Show InChI InChI=1S/C25H25N3O6/c1-14-15(2)34-28-25(14)27-24(29)10-16-6-7-17(11-21(16)30-3)33-20-8-9-26-19-13-23(32-5)22(31-4)12-18(19)20/h6-9,11-13H,10H2,1-5H3,(H,27,28,29)
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n/an/a 0.200n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50381946
PNG
(CHEMBL2023485)
Show SMILES CCc1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cc2OC)[nH]n1
Show InChI InChI=1S/C25H26N4O5/c1-5-16-11-24(29-28-16)27-25(30)10-15-6-7-17(12-21(15)31-2)34-20-8-9-26-19-14-23(33-4)22(32-3)13-18(19)20/h6-9,11-14H,5,10H2,1-4H3,(H2,27,28,29,30)
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n/an/a 0.200n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50381931
PNG
(CHEMBL2023476)
Show SMILES COc1ccc2c(Oc3ccc(CC(=O)Nc4ncc(C)s4)c(OC)c3)ccnc2c1
Show InChI InChI=1S/C23H21N3O4S/c1-14-13-25-23(31-14)26-22(27)10-15-4-5-17(12-21(15)29-3)30-20-8-9-24-19-11-16(28-2)6-7-18(19)20/h4-9,11-13H,10H2,1-3H3,(H,25,26,27)
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n/an/a 0.300n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50381947
PNG
(CHEMBL2023482)
Show SMILES CCc1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)ccc34)cc2OC)no1
Show InChI InChI=1S/C24H23N3O5/c1-4-16-14-23(27-32-16)26-24(28)11-15-5-6-18(13-22(15)30-3)31-21-9-10-25-20-12-17(29-2)7-8-19(20)21/h5-10,12-14H,4,11H2,1-3H3,(H,26,27,28)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50381948
PNG
(CHEMBL2023486)
Show SMILES CCc1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)ccc34)cc2OC)[nH]n1
Show InChI InChI=1S/C24H24N4O4/c1-4-16-12-23(28-27-16)26-24(29)11-15-5-6-18(14-22(15)31-3)32-21-9-10-25-20-13-17(30-2)7-8-19(20)21/h5-10,12-14H,4,11H2,1-3H3,(H2,26,27,28,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50381949
PNG
(CHEMBL2023118)
Show SMILES CCn1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)ccc34)cc2OC)cn1
Show InChI InChI=1S/C24H24N4O4/c1-4-28-15-17(14-26-28)27-24(29)11-16-5-6-19(13-23(16)31-3)32-22-9-10-25-21-12-18(30-2)7-8-20(21)22/h5-10,12-15H,4,11H2,1-3H3,(H,27,29)
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n/an/a 0.700n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50381923
PNG
(CHEMBL2023117)
Show SMILES CCn1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cc2OC)cn1
Show InChI InChI=1S/C25H26N4O5/c1-5-29-15-17(14-27-29)28-25(30)10-16-6-7-18(11-22(16)31-2)34-21-8-9-26-20-13-24(33-4)23(32-3)12-19(20)21/h6-9,11-15H,5,10H2,1-4H3,(H,28,30)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50381936
PNG
(CHEMBL2023478)
Show SMILES COc1ccc2c(Oc3ccc(CC(=O)Nc4noc(C)c4C)c(OC)c3)ccnc2c1
Show InChI InChI=1S/C24H23N3O5/c1-14-15(2)32-27-24(14)26-23(28)11-16-5-6-18(13-22(16)30-4)31-21-9-10-25-20-12-17(29-3)7-8-19(20)21/h5-10,12-13H,11H2,1-4H3,(H,26,27,28)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50381930
PNG
(CHEMBL2023495)
Show SMILES CCn1cc(NC(=O)Cc2ncc(Oc3ccnc4cc(OC)ccc34)cc2OC)cn1
Show InChI InChI=1S/C23H23N5O4/c1-4-28-14-15(12-26-28)27-23(29)11-20-22(31-3)10-17(13-25-20)32-21-7-8-24-19-9-16(30-2)5-6-18(19)21/h5-10,12-14H,4,11H2,1-3H3,(H,27,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50381924
PNG
(CHEMBL2023484)
Show SMILES CCc1cn[nH]c1NC(=O)Cc1ccc(Oc2ccnc3cc(OC)ccc23)cc1OC
Show InChI InChI=1S/C24H24N4O4/c1-4-15-14-26-28-24(15)27-23(29)11-16-5-6-18(13-22(16)31-3)32-21-9-10-25-20-12-17(30-2)7-8-19(20)21/h5-10,12-14H,4,11H2,1-3H3,(H2,26,27,28,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50381923
PNG
(CHEMBL2023117)
Show SMILES CCn1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cc2OC)cn1
Show InChI InChI=1S/C25H26N4O5/c1-5-29-15-17(14-27-29)28-25(30)10-16-6-7-18(11-22(16)31-2)34-21-8-9-26-20-13-24(33-4)23(32-3)12-19(20)21/h6-9,11-15H,5,10H2,1-4H3,(H,28,30)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of CSF-1R


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50381922
PNG
(CHEMBL2023800)
Show SMILES CCn1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cn2)cn1
Show InChI InChI=1S/C23H23N5O4/c1-4-28-14-16(12-26-28)27-23(29)9-15-5-6-17(13-25-15)32-20-7-8-24-19-11-22(31-3)21(30-2)10-18(19)20/h5-8,10-14H,4,9H2,1-3H3,(H,27,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50381928
PNG
(CHEMBL2023802)
Show SMILES CCOc1cc2nccc(Oc3cnc(CC(=O)Nc4[nH]nc(CC)c4C)c(OC)c3)c2cc1OC
Show InChI InChI=1S/C26H29N5O5/c1-6-18-15(3)26(31-30-18)29-25(32)13-20-22(33-4)10-16(14-28-20)36-21-8-9-27-19-12-24(35-7-2)23(34-5)11-17(19)21/h8-12,14H,6-7,13H2,1-5H3,(H2,29,30,31,32)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50381920
PNG
(CHEMBL2023119)
Show SMILES CCn1cc(NC(=O)Cc2ccc(Oc3ccnc4ccc(OC)cc34)cc2OC)cn1
Show InChI InChI=1S/C24H24N4O4/c1-4-28-15-17(14-26-28)27-24(29)11-16-5-6-19(13-23(16)31-3)32-22-9-10-25-21-8-7-18(30-2)12-20(21)22/h5-10,12-15H,4,11H2,1-3H3,(H,27,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50381946
PNG
(CHEMBL2023485)
Show SMILES CCc1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cc2OC)[nH]n1
Show InChI InChI=1S/C25H26N4O5/c1-5-16-11-24(29-28-16)27-25(30)10-15-6-7-17(12-21(15)31-2)34-20-8-9-26-19-14-23(33-4)22(32-3)13-18(19)20/h6-9,11-14H,5,10H2,1-4H3,(H2,27,28,29,30)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50381929
PNG
(CHEMBL2023115)
Show SMILES CCn1cc(NC(=O)Cc2ccc(Oc3ncnc4cc(OC)c(OC)cc34)cc2OC)cn1
Show InChI InChI=1S/C24H25N5O5/c1-5-29-13-16(12-27-29)28-23(30)8-15-6-7-17(9-20(15)31-2)34-24-18-10-21(32-3)22(33-4)11-19(18)25-14-26-24/h6-7,9-14H,5,8H2,1-4H3,(H,28,30)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Homo sapiens (Human))
BDBM50381926
PNG
(CHEMBL2023489 | CHEMBL2023803)
Show SMILES COc1ccc2c(Oc3ccc(CC(=O)Nc4cn(C)nc4C)c(OC)c3)ccnc2c1
Show InChI InChI=1S/C24H24N4O4/c1-15-21(14-28(2)27-15)26-24(29)11-16-5-6-18(13-23(16)31-4)32-22-9-10-25-20-12-17(30-3)7-8-19(20)22/h5-10,12-14H,11H2,1-4H3,(H,26,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PDGFRalpha


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50381947
PNG
(CHEMBL2023482)
Show SMILES CCc1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)ccc34)cc2OC)no1
Show InChI InChI=1S/C24H23N3O5/c1-4-16-14-23(27-32-16)26-24(28)11-15-5-6-18(13-22(15)30-3)31-21-9-10-25-20-12-17(29-2)7-8-19(20)21/h5-10,12-14H,4,11H2,1-3H3,(H,26,27,28)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of CSF-1R


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50381938
PNG
(CHEMBL2023483)
Show SMILES COc1ccc2c(Oc3ccc(CC(=O)Nc4[nH]nc(C)c4C)c(OC)c3)ccnc2c1
Show InChI InChI=1S/C24H24N4O4/c1-14-15(2)27-28-24(14)26-23(29)11-16-5-6-18(13-22(16)31-4)32-21-9-10-25-20-12-17(30-3)7-8-19(20)21/h5-10,12-13H,11H2,1-4H3,(H2,26,27,28,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50381944
PNG
(CHEMBL2023801)
Show SMILES CCc1n[nH]c(NC(=O)Cc2ncc(Oc3ccnc4cc(OC)c(OC)cc34)cc2OC)c1C
Show InChI InChI=1S/C25H27N5O5/c1-6-17-14(2)25(30-29-17)28-24(31)12-19-21(32-3)9-15(13-27-19)35-20-7-8-26-18-11-23(34-5)22(33-4)10-16(18)20/h7-11,13H,6,12H2,1-5H3,(H2,28,29,30,31)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50381926
PNG
(CHEMBL2023489 | CHEMBL2023803)
Show SMILES COc1ccc2c(Oc3ccc(CC(=O)Nc4cn(C)nc4C)c(OC)c3)ccnc2c1
Show InChI InChI=1S/C24H24N4O4/c1-15-21(14-28(2)27-15)26-24(29)11-16-5-6-18(13-23(16)31-4)32-22-9-10-25-20-12-17(30-3)7-8-19(20)22/h5-10,12-14H,11H2,1-4H3,(H,26,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50381948
PNG
(CHEMBL2023486)
Show SMILES CCc1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)ccc34)cc2OC)[nH]n1
Show InChI InChI=1S/C24H24N4O4/c1-4-16-12-23(28-27-16)26-24(29)11-15-5-6-18(14-22(15)31-3)32-21-9-10-25-20-13-17(30-2)7-8-19(20)21/h5-10,12-14H,4,11H2,1-3H3,(H2,26,27,28,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50362058
PNG
(CHEMBL1940274)
Show SMILES COc1cc2ncnc(Oc3ccc(CC(=O)Nc4cnn(c4)C(C)C)cc3)c2cc1OC
Show InChI InChI=1S/C24H25N5O4/c1-15(2)29-13-17(12-27-29)28-23(30)9-16-5-7-18(8-6-16)33-24-19-10-21(31-3)22(32-4)11-20(19)25-14-26-24/h5-8,10-15H,9H2,1-4H3,(H,28,30)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50381950
PNG
(CHEMBL2023494)
Show SMILES COc1ccc2c(Oc3ccc(CC(=O)Nc4cc(C)cc(CN(C)C)c4)c(OC)c3)ccnc2c1
Show InChI InChI=1S/C29H31N3O4/c1-19-12-20(18-32(2)3)14-22(13-19)31-29(33)15-21-6-7-24(17-28(21)35-5)36-27-10-11-30-26-16-23(34-4)8-9-25(26)27/h6-14,16-17H,15,18H2,1-5H3,(H,31,33)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50381948
PNG
(CHEMBL2023486)
Show SMILES CCc1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)ccc34)cc2OC)[nH]n1
Show InChI InChI=1S/C24H24N4O4/c1-4-16-12-23(28-27-16)26-24(29)11-15-5-6-18(14-22(15)31-3)32-21-9-10-25-20-13-17(30-2)7-8-19(20)21/h5-10,12-14H,4,11H2,1-3H3,(H2,26,27,28,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of CSF-1R


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50381937
PNG
(CHEMBL2023479)
Show SMILES COc1ccc2nccc(Oc3ccc(CC(=O)Nc4noc(C)c4C)c(OC)c3)c2c1
Show InChI InChI=1S/C24H23N3O5/c1-14-15(2)32-27-24(14)26-23(28)11-16-5-6-18(13-22(16)30-4)31-21-9-10-25-20-8-7-17(29-3)12-19(20)21/h5-10,12-13H,11H2,1-4H3,(H,26,27,28)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50381942
PNG
(CHEMBL2023493)
Show SMILES COc1ccc2c(Oc3ccc(CC(=O)Nc4cc(C)nn4C)c(OC)c3)ccnc2c1
Show InChI InChI=1S/C24H24N4O4/c1-15-11-23(28(2)27-15)26-24(29)12-16-5-6-18(14-22(16)31-4)32-21-9-10-25-20-13-17(30-3)7-8-19(20)21/h5-11,13-14H,12H2,1-4H3,(H,26,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50381949
PNG
(CHEMBL2023118)
Show SMILES CCn1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)ccc34)cc2OC)cn1
Show InChI InChI=1S/C24H24N4O4/c1-4-28-15-17(14-26-28)27-24(29)11-16-5-6-19(13-23(16)31-3)32-22-9-10-25-21-12-18(30-2)7-8-20(21)22/h5-10,12-15H,4,11H2,1-3H3,(H,27,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of CSF-1R


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50381925
PNG
(CHEMBL2023481)
Show SMILES COc1cc(Oc2ccnc3ccc(F)cc23)ccc1CC(=O)Nc1noc(C)c1C
Show InChI InChI=1S/C23H20FN3O4/c1-13-14(2)31-27-23(13)26-22(28)10-15-4-6-17(12-21(15)29-3)30-20-8-9-25-19-7-5-16(24)11-18(19)20/h4-9,11-12H,10H2,1-3H3,(H,26,27,28)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50381941
PNG
(CHEMBL2023492)
Show SMILES COc1ccc2c(Oc3ccc(CC(=O)Nc4cnn(C)c4)c(OC)c3)ccnc2c1
Show InChI InChI=1S/C23H22N4O4/c1-27-14-16(13-25-27)26-23(28)10-15-4-5-18(12-22(15)30-3)31-21-8-9-24-20-11-17(29-2)6-7-19(20)21/h4-9,11-14H,10H2,1-3H3,(H,26,28)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50381939
PNG
(CHEMBL2023488)
Show SMILES COc1cc(Oc2ccnc3cc(OC)c(OC)cc23)ccc1CC(=O)Nc1cn(C)nc1C
Show InChI InChI=1S/C25H26N4O5/c1-15-20(14-29(2)28-15)27-25(30)10-16-6-7-17(11-22(16)31-3)34-21-8-9-26-19-13-24(33-5)23(32-4)12-18(19)21/h6-9,11-14H,10H2,1-5H3,(H,27,30)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50381934
PNG
(CHEMBL2023474)
Show SMILES CCn1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(F)ccc34)cc2OC)cn1
Show InChI InChI=1S/C23H21FN4O3/c1-3-28-14-17(13-26-28)27-23(29)10-15-4-6-18(12-22(15)30-2)31-21-8-9-25-20-11-16(24)5-7-19(20)21/h4-9,11-14H,3,10H2,1-2H3,(H,27,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50381921
PNG
(CHEMBL2023480)
Show SMILES COc1cc(Oc2ccnc3cc(F)ccc23)ccc1CC(=O)Nc1noc(C)c1C
Show InChI InChI=1S/C23H20FN3O4/c1-13-14(2)31-27-23(13)26-22(28)10-15-4-6-17(12-21(15)29-3)30-20-8-9-25-19-11-16(24)5-7-18(19)20/h4-9,11-12H,10H2,1-3H3,(H,26,27,28)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50362058
PNG
(CHEMBL1940274)
Show SMILES COc1cc2ncnc(Oc3ccc(CC(=O)Nc4cnn(c4)C(C)C)cc3)c2cc1OC
Show InChI InChI=1S/C24H25N5O4/c1-15(2)29-13-17(12-27-29)28-23(30)9-16-5-7-18(8-6-16)33-24-19-10-21(31-3)22(32-4)11-20(19)25-14-26-24/h5-8,10-15H,9H2,1-4H3,(H,28,30)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of Flt3


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50381935
PNG
(CHEMBL2023475)
Show SMILES CCn1cc(NC(=O)Cc2ccc(Oc3ccnc4ccc(F)cc34)cc2OC)cn1
Show InChI InChI=1S/C23H21FN4O3/c1-3-28-14-17(13-26-28)27-23(29)10-15-4-6-18(12-22(15)30-2)31-21-8-9-25-20-7-5-16(24)11-19(20)21/h4-9,11-14H,3,10H2,1-2H3,(H,27,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50362058
PNG
(CHEMBL1940274)
Show SMILES COc1cc2ncnc(Oc3ccc(CC(=O)Nc4cnn(c4)C(C)C)cc3)c2cc1OC
Show InChI InChI=1S/C24H25N5O4/c1-15(2)29-13-17(12-27-29)28-23(30)9-16-5-7-18(8-6-16)33-24-19-10-21(31-3)22(32-4)11-20(19)25-14-26-24/h5-8,10-15H,9H2,1-4H3,(H,28,30)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50381950
PNG
(CHEMBL2023494)
Show SMILES COc1ccc2c(Oc3ccc(CC(=O)Nc4cc(C)cc(CN(C)C)c4)c(OC)c3)ccnc2c1
Show InChI InChI=1S/C29H31N3O4/c1-19-12-20(18-32(2)3)14-22(13-19)31-29(33)15-21-6-7-24(17-28(21)35-5)36-27-10-11-30-26-16-23(34-4)8-9-25(26)27/h6-14,16-17H,15,18H2,1-5H3,(H,31,33)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of CSF-1R


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50381940
PNG
(CHEMBL2023491)
Show SMILES COc1ccc2c(Oc3ccc(CC(=O)Nc4cnn(C)c4C)c(OC)c3)ccnc2c1
Show InChI InChI=1S/C24H24N4O4/c1-15-21(14-26-28(15)2)27-24(29)11-16-5-6-18(13-23(16)31-4)32-22-9-10-25-20-12-17(30-3)7-8-19(20)22/h5-10,12-14H,11H2,1-4H3,(H,27,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50381931
PNG
(CHEMBL2023476)
Show SMILES COc1ccc2c(Oc3ccc(CC(=O)Nc4ncc(C)s4)c(OC)c3)ccnc2c1
Show InChI InChI=1S/C23H21N3O4S/c1-14-13-25-23(31-14)26-22(27)10-15-4-5-17(12-21(15)29-3)30-20-8-9-24-19-11-16(28-2)6-7-18(19)20/h4-9,11-13H,10H2,1-3H3,(H,25,26,27)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of CSF-1R


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50381951
PNG
(CHEMBL2023490)
Show SMILES COc1cc2nccc(Oc3ccc(CC(=O)Nc4cn(C)nc4C)cc3)c2cc1OC
Show InChI InChI=1S/C24H24N4O4/c1-15-20(14-28(2)27-15)26-24(29)11-16-5-7-17(8-6-16)32-21-9-10-25-19-13-23(31-4)22(30-3)12-18(19)21/h5-10,12-14H,11H2,1-4H3,(H,26,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50362090
PNG
(CHEMBL1940275)
Show SMILES COc1cc2ncnc(Nc3ccc(CC(=O)Nc4cnn(c4)C(C)C)cc3)c2cc1OC
Show InChI InChI=1S/C24H26N6O3/c1-15(2)30-13-18(12-27-30)28-23(31)9-16-5-7-17(8-6-16)29-24-19-10-21(32-3)22(33-4)11-20(19)25-14-26-24/h5-8,10-15H,9H2,1-4H3,(H,28,31)(H,25,26,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of Flt3


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50362090
PNG
(CHEMBL1940275)
Show SMILES COc1cc2ncnc(Nc3ccc(CC(=O)Nc4cnn(c4)C(C)C)cc3)c2cc1OC
Show InChI InChI=1S/C24H26N6O3/c1-15(2)30-13-18(12-27-30)28-23(31)9-16-5-7-17(8-6-16)29-24-19-10-21(32-3)22(33-4)11-20(19)25-14-26-24/h5-8,10-15H,9H2,1-4H3,(H,28,31)(H,25,26,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50381947
PNG
(CHEMBL2023482)
Show SMILES CCc1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)ccc34)cc2OC)no1
Show InChI InChI=1S/C24H23N3O5/c1-4-16-14-23(27-32-16)26-24(28)11-15-5-6-18(13-22(15)30-3)31-21-9-10-25-20-12-17(29-2)7-8-19(20)21/h5-10,12-14H,4,11H2,1-3H3,(H,26,27,28)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50381931
PNG
(CHEMBL2023476)
Show SMILES COc1ccc2c(Oc3ccc(CC(=O)Nc4ncc(C)s4)c(OC)c3)ccnc2c1
Show InChI InChI=1S/C23H21N3O4S/c1-14-13-25-23(31-14)26-22(27)10-15-4-5-17(12-21(15)29-3)30-20-8-9-24-19-11-16(28-2)6-7-18(19)20/h4-9,11-13H,10H2,1-3H3,(H,25,26,27)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50381930
PNG
(CHEMBL2023495)
Show SMILES CCn1cc(NC(=O)Cc2ncc(Oc3ccnc4cc(OC)ccc34)cc2OC)cn1
Show InChI InChI=1S/C23H23N5O4/c1-4-28-14-15(12-26-28)27-23(29)11-20-22(31-3)10-17(13-25-20)32-21-7-8-24-19-9-16(30-2)5-6-18(19)21/h5-10,12-14H,4,11H2,1-3H3,(H,27,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of CSF-1R


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50381945
PNG
(CHEMBL2023477)
Show SMILES COc1cc(Oc2ccnc3cc(OC)c(OC)cc23)ccc1CC(=O)Nc1noc(C)c1C
Show InChI InChI=1S/C25H25N3O6/c1-14-15(2)34-28-25(14)27-24(29)10-16-6-7-17(11-21(16)30-3)33-20-8-9-26-19-13-23(32-5)22(31-4)12-18(19)20/h6-9,11-13H,10H2,1-5H3,(H,27,28,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of CSF-1R


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50381943
PNG
(CHEMBL2023496)
Show SMILES COc1ccc2c(Oc3cnc(CC(=O)Nc4cn(C)nc4C)c(OC)c3)ccnc2c1
Show InChI InChI=1S/C23H23N5O4/c1-14-20(13-28(2)27-14)26-23(29)11-19-22(31-4)10-16(12-25-19)32-21-7-8-24-18-9-15(30-3)5-6-17(18)21/h5-10,12-13H,11H2,1-4H3,(H,26,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50381950
PNG
(CHEMBL2023494)
Show SMILES COc1ccc2c(Oc3ccc(CC(=O)Nc4cc(C)cc(CN(C)C)c4)c(OC)c3)ccnc2c1
Show InChI InChI=1S/C29H31N3O4/c1-19-12-20(18-32(2)3)14-22(13-19)31-29(33)15-21-6-7-24(17-28(21)35-5)36-27-10-11-30-26-16-23(34-4)8-9-25(26)27/h6-14,16-17H,15,18H2,1-5H3,(H,31,33)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50381936
PNG
(CHEMBL2023478)
Show SMILES COc1ccc2c(Oc3ccc(CC(=O)Nc4noc(C)c4C)c(OC)c3)ccnc2c1
Show InChI InChI=1S/C24H23N3O5/c1-14-15(2)32-27-24(14)26-23(28)11-16-5-6-18(13-22(16)30-4)31-21-9-10-25-20-12-17(29-3)7-8-19(20)21/h5-10,12-13H,11H2,1-4H3,(H,26,27,28)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of CSF-1R


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50381951
PNG
(CHEMBL2023490)
Show SMILES COc1cc2nccc(Oc3ccc(CC(=O)Nc4cn(C)nc4C)cc3)c2cc1OC
Show InChI InChI=1S/C24H24N4O4/c1-15-20(14-28(2)27-15)26-24(29)11-16-5-7-17(8-6-16)32-21-9-10-25-19-13-23(31-4)22(30-3)12-18(19)21/h5-10,12-14H,11H2,1-4H3,(H,26,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of Flt3


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50381922
PNG
(CHEMBL2023800)
Show SMILES CCn1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cn2)cn1
Show InChI InChI=1S/C23H23N5O4/c1-4-28-14-16(12-26-28)27-23(29)9-15-5-6-17(13-25-15)32-20-7-8-24-19-11-22(31-3)21(30-2)10-18(19)20/h5-8,10-14H,4,9H2,1-3H3,(H,27,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of Flt3


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50381932
PNG
(CHEMBL2023116)
Show SMILES CCn1cc(NC(=O)Cc2ccc(Oc3ncnc4cc(OC)c(OC)cc34)c(OC)c2)cn1
Show InChI InChI=1S/C24H25N5O5/c1-5-29-13-16(12-27-29)28-23(30)9-15-6-7-19(20(8-15)31-2)34-24-17-10-21(32-3)22(33-4)11-18(17)25-14-26-24/h6-8,10-14H,5,9H2,1-4H3,(H,28,30)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50381939
PNG
(CHEMBL2023488)
Show SMILES COc1cc(Oc2ccnc3cc(OC)c(OC)cc23)ccc1CC(=O)Nc1cn(C)nc1C
Show InChI InChI=1S/C25H26N4O5/c1-15-20(14-29(2)28-15)27-25(30)10-16-6-7-17(11-22(16)31-3)34-21-8-9-26-19-13-24(33-5)23(32-4)12-18(19)21/h6-9,11-14H,10H2,1-5H3,(H,27,30)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of CSF-1R


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50381933
PNG
(CHEMBL2023487)
Show SMILES COc1cc(Oc2ncnc3cc(OC)c(OC)cc23)ccc1CC(=O)Nc1cn(C)nc1C
Show InChI InChI=1S/C24H25N5O5/c1-14-19(12-29(2)28-14)27-23(30)8-15-6-7-16(9-20(15)31-3)34-24-17-10-21(32-4)22(33-5)11-18(17)25-13-26-24/h6-7,9-13H,8H2,1-5H3,(H,27,30)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50381946
PNG
(CHEMBL2023485)
Show SMILES CCc1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cc2OC)[nH]n1
Show InChI InChI=1S/C25H26N4O5/c1-5-16-11-24(29-28-16)27-25(30)10-15-6-7-17(12-21(15)31-2)34-20-8-9-26-19-14-23(33-4)22(32-3)13-18(19)20/h6-9,11-14H,5,10H2,1-4H3,(H2,27,28,29,30)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of Flt3


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50381949
PNG
(CHEMBL2023118)
Show SMILES CCn1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)ccc34)cc2OC)cn1
Show InChI InChI=1S/C24H24N4O4/c1-4-28-15-17(14-26-28)27-24(29)11-16-5-6-19(13-23(16)31-3)32-22-9-10-25-21-12-18(30-2)7-8-20(21)22/h5-10,12-15H,4,11H2,1-3H3,(H,27,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50381943
PNG
(CHEMBL2023496)
Show SMILES COc1ccc2c(Oc3cnc(CC(=O)Nc4cn(C)nc4C)c(OC)c3)ccnc2c1
Show InChI InChI=1S/C23H23N5O4/c1-14-20(13-28(2)27-14)26-23(29)11-19-22(31-4)10-16(12-25-19)32-21-7-8-24-18-9-15(30-3)5-6-17(18)21/h5-10,12-13H,11H2,1-4H3,(H,26,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of CSF-1R


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50381947
PNG
(CHEMBL2023482)
Show SMILES CCc1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)ccc34)cc2OC)no1
Show InChI InChI=1S/C24H23N3O5/c1-4-16-14-23(27-32-16)26-24(28)11-15-5-6-18(13-22(15)30-3)31-21-9-10-25-20-12-17(29-2)7-8-19(20)21/h5-10,12-14H,4,11H2,1-3H3,(H,26,27,28)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of Flt3


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50381923
PNG
(CHEMBL2023117)
Show SMILES CCn1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cc2OC)cn1
Show InChI InChI=1S/C25H26N4O5/c1-5-29-15-17(14-27-29)28-25(30)10-16-6-7-18(11-22(16)31-2)34-21-8-9-26-20-13-24(33-4)23(32-3)12-19(20)21/h6-9,11-15H,5,10H2,1-4H3,(H,28,30)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50381938
PNG
(CHEMBL2023483)
Show SMILES COc1ccc2c(Oc3ccc(CC(=O)Nc4[nH]nc(C)c4C)c(OC)c3)ccnc2c1
Show InChI InChI=1S/C24H24N4O4/c1-14-15(2)27-28-24(14)26-23(29)11-16-5-6-18(13-22(16)31-4)32-21-9-10-25-20-12-17(30-3)7-8-19(20)21/h5-10,12-13H,11H2,1-4H3,(H2,26,27,28,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of CSF-1R


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50381941
PNG
(CHEMBL2023492)
Show SMILES COc1ccc2c(Oc3ccc(CC(=O)Nc4cnn(C)c4)c(OC)c3)ccnc2c1
Show InChI InChI=1S/C23H22N4O4/c1-27-14-16(13-25-27)26-23(28)10-15-4-5-18(12-22(15)30-3)31-21-8-9-24-20-11-17(29-2)6-7-19(20)21/h4-9,11-14H,10H2,1-3H3,(H,26,28)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of CSF-1R


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50381924
PNG
(CHEMBL2023484)
Show SMILES CCc1cn[nH]c1NC(=O)Cc1ccc(Oc2ccnc3cc(OC)ccc23)cc1OC
Show InChI InChI=1S/C24H24N4O4/c1-4-15-14-26-28-24(15)27-23(29)11-16-5-6-18(13-22(16)31-3)32-21-9-10-25-20-12-17(30-2)7-8-19(20)21/h5-10,12-14H,4,11H2,1-3H3,(H2,26,27,28,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of CSF-1R


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50381942
PNG
(CHEMBL2023493)
Show SMILES COc1ccc2c(Oc3ccc(CC(=O)Nc4cc(C)nn4C)c(OC)c3)ccnc2c1
Show InChI InChI=1S/C24H24N4O4/c1-15-11-23(28(2)27-15)26-24(29)12-16-5-6-18(14-22(16)31-4)32-21-9-10-25-20-13-17(30-3)7-8-19(20)21/h5-11,13-14H,12H2,1-4H3,(H,26,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of CSF-1R


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50362058
PNG
(CHEMBL1940274)
Show SMILES COc1cc2ncnc(Oc3ccc(CC(=O)Nc4cnn(c4)C(C)C)cc3)c2cc1OC
Show InChI InChI=1S/C24H25N5O4/c1-15(2)29-13-17(12-27-29)28-23(30)9-16-5-7-18(8-6-16)33-24-19-10-21(31-3)22(32-4)11-20(19)25-14-26-24/h5-8,10-15H,9H2,1-4H3,(H,28,30)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of CSF-1R


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50381951
PNG
(CHEMBL2023490)
Show SMILES COc1cc2nccc(Oc3ccc(CC(=O)Nc4cn(C)nc4C)cc3)c2cc1OC
Show InChI InChI=1S/C24H24N4O4/c1-15-20(14-28(2)27-15)26-24(29)11-16-5-7-17(8-6-16)32-21-9-10-25-19-13-23(31-4)22(30-3)12-18(19)21/h5-10,12-14H,11H2,1-4H3,(H,26,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50381932
PNG
(CHEMBL2023116)
Show SMILES CCn1cc(NC(=O)Cc2ccc(Oc3ncnc4cc(OC)c(OC)cc34)c(OC)c2)cn1
Show InChI InChI=1S/C24H25N5O5/c1-5-29-13-16(12-27-29)28-23(30)9-15-6-7-19(20(8-15)31-2)34-24-17-10-21(32-3)22(33-4)11-18(17)25-14-26-24/h6-8,10-14H,5,9H2,1-4H3,(H,28,30)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of Flt3


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50381928
PNG
(CHEMBL2023802)
Show SMILES CCOc1cc2nccc(Oc3cnc(CC(=O)Nc4[nH]nc(CC)c4C)c(OC)c3)c2cc1OC
Show InChI InChI=1S/C26H29N5O5/c1-6-18-15(3)26(31-30-18)29-25(32)13-20-22(33-4)10-16(14-28-20)36-21-8-9-27-19-12-24(35-7-2)23(34-5)11-17(19)21/h8-12,14H,6-7,13H2,1-5H3,(H2,29,30,31,32)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of CSF-1R


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50381926
PNG
(CHEMBL2023489 | CHEMBL2023803)
Show SMILES COc1ccc2c(Oc3ccc(CC(=O)Nc4cn(C)nc4C)c(OC)c3)ccnc2c1
Show InChI InChI=1S/C24H24N4O4/c1-15-21(14-28(2)27-15)26-24(29)11-16-5-6-18(13-23(16)31-4)32-22-9-10-25-20-12-17(30-3)7-8-19(20)22/h5-10,12-14H,11H2,1-4H3,(H,26,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of CSF-1R


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50381920
PNG
(CHEMBL2023119)
Show SMILES CCn1cc(NC(=O)Cc2ccc(Oc3ccnc4ccc(OC)cc34)cc2OC)cn1
Show InChI InChI=1S/C24H24N4O4/c1-4-28-15-17(14-26-28)27-24(29)11-16-5-6-19(13-23(16)31-3)32-22-9-10-25-21-8-7-18(30-2)12-20(21)22/h5-10,12-15H,4,11H2,1-3H3,(H,27,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of CSF-1R


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50381923
PNG
(CHEMBL2023117)
Show SMILES CCn1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cc2OC)cn1
Show InChI InChI=1S/C25H26N4O5/c1-5-29-15-17(14-27-29)28-25(30)10-16-6-7-18(11-22(16)31-2)34-21-8-9-26-20-13-24(33-4)23(32-3)12-19(20)21/h6-9,11-15H,5,10H2,1-4H3,(H,28,30)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of Flt3


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50381922
PNG
(CHEMBL2023800)
Show SMILES CCn1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cn2)cn1
Show InChI InChI=1S/C23H23N5O4/c1-4-28-14-16(12-26-28)27-23(29)9-15-5-6-17(13-25-15)32-20-7-8-24-19-11-22(31-3)21(30-2)10-18(19)20/h5-8,10-14H,4,9H2,1-3H3,(H,27,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50381951
PNG
(CHEMBL2023490)
Show SMILES COc1cc2nccc(Oc3ccc(CC(=O)Nc4cn(C)nc4C)cc3)c2cc1OC
Show InChI InChI=1S/C24H24N4O4/c1-15-20(14-28(2)27-15)26-24(29)11-16-5-7-17(8-6-16)32-21-9-10-25-19-13-23(31-4)22(30-3)12-18(19)21/h5-10,12-14H,11H2,1-4H3,(H,26,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of CSF-1R


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50381950
PNG
(CHEMBL2023494)
Show SMILES COc1ccc2c(Oc3ccc(CC(=O)Nc4cc(C)cc(CN(C)C)c4)c(OC)c3)ccnc2c1
Show InChI InChI=1S/C29H31N3O4/c1-19-12-20(18-32(2)3)14-22(13-19)31-29(33)15-21-6-7-24(17-28(21)35-5)36-27-10-11-30-26-16-23(34-4)8-9-25(26)27/h6-14,16-17H,15,18H2,1-5H3,(H,31,33)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of Flt3


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50381922
PNG
(CHEMBL2023800)
Show SMILES CCn1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cn2)cn1
Show InChI InChI=1S/C23H23N5O4/c1-4-28-14-16(12-26-28)27-23(29)9-15-5-6-17(13-25-15)32-20-7-8-24-19-11-22(31-3)21(30-2)10-18(19)20/h5-8,10-14H,4,9H2,1-3H3,(H,27,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of CSF-1R


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50381948
PNG
(CHEMBL2023486)
Show SMILES CCc1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)ccc34)cc2OC)[nH]n1
Show InChI InChI=1S/C24H24N4O4/c1-4-16-12-23(28-27-16)26-24(29)11-15-5-6-18(14-22(15)31-3)32-21-9-10-25-20-13-17(30-2)7-8-19(20)21/h5-10,12-14H,4,11H2,1-3H3,(H2,26,27,28,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of Flt3


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50362090
PNG
(CHEMBL1940275)
Show SMILES COc1cc2ncnc(Nc3ccc(CC(=O)Nc4cnn(c4)C(C)C)cc3)c2cc1OC
Show InChI InChI=1S/C24H26N6O3/c1-15(2)30-13-18(12-27-30)28-23(31)9-16-5-7-17(8-6-16)29-24-19-10-21(32-3)22(33-4)11-20(19)25-14-26-24/h5-8,10-15H,9H2,1-4H3,(H,28,31)(H,25,26,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50381934
PNG
(CHEMBL2023474)
Show SMILES CCn1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(F)ccc34)cc2OC)cn1
Show InChI InChI=1S/C23H21FN4O3/c1-3-28-14-17(13-26-28)27-23(29)10-15-4-6-18(12-22(15)30-2)31-21-8-9-25-20-11-16(24)5-7-19(20)21/h4-9,11-14H,3,10H2,1-2H3,(H,27,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of CSF-1R


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50381945
PNG
(CHEMBL2023477)
Show SMILES COc1cc(Oc2ccnc3cc(OC)c(OC)cc23)ccc1CC(=O)Nc1noc(C)c1C
Show InChI InChI=1S/C25H25N3O6/c1-14-15(2)34-28-25(14)27-24(29)10-16-6-7-17(11-21(16)30-3)33-20-8-9-26-19-13-23(32-5)22(31-4)12-18(19)20/h6-9,11-13H,10H2,1-5H3,(H,27,28,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of Flt3


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50381940
PNG
(CHEMBL2023491)
Show SMILES COc1ccc2c(Oc3ccc(CC(=O)Nc4cnn(C)c4C)c(OC)c3)ccnc2c1
Show InChI InChI=1S/C24H24N4O4/c1-15-21(14-26-28(15)2)27-24(29)11-16-5-6-18(13-23(16)31-4)32-22-9-10-25-20-12-17(30-3)7-8-19(20)22/h5-10,12-14H,11H2,1-4H3,(H,27,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of CSF-1R


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50381929
PNG
(CHEMBL2023115)
Show SMILES CCn1cc(NC(=O)Cc2ccc(Oc3ncnc4cc(OC)c(OC)cc34)cc2OC)cn1
Show InChI InChI=1S/C24H25N5O5/c1-5-29-13-16(12-27-29)28-23(30)8-15-6-7-17(9-20(15)31-2)34-24-18-10-21(32-3)22(33-4)11-19(18)25-14-26-24/h6-7,9-14H,5,8H2,1-4H3,(H,28,30)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of CSF-1R


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50381938
PNG
(CHEMBL2023483)
Show SMILES COc1ccc2c(Oc3ccc(CC(=O)Nc4[nH]nc(C)c4C)c(OC)c3)ccnc2c1
Show InChI InChI=1S/C24H24N4O4/c1-14-15(2)27-28-24(14)26-23(29)11-16-5-6-18(13-22(16)31-4)32-21-9-10-25-20-12-17(30-3)7-8-19(20)21/h5-10,12-13H,11H2,1-4H3,(H2,26,27,28,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50381937
PNG
(CHEMBL2023479)
Show SMILES COc1ccc2nccc(Oc3ccc(CC(=O)Nc4noc(C)c4C)c(OC)c3)c2c1
Show InChI InChI=1S/C24H23N3O5/c1-14-15(2)32-27-24(14)26-23(28)11-16-5-6-18(13-22(16)30-4)31-21-9-10-25-20-8-7-17(29-3)12-19(20)21/h5-10,12-13H,11H2,1-4H3,(H,26,27,28)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of CSF-1R


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50381944
PNG
(CHEMBL2023801)
Show SMILES CCc1n[nH]c(NC(=O)Cc2ncc(Oc3ccnc4cc(OC)c(OC)cc34)cc2OC)c1C
Show InChI InChI=1S/C25H27N5O5/c1-6-17-14(2)25(30-29-17)28-24(31)12-19-21(32-3)9-15(13-27-19)35-20-7-8-26-18-11-23(34-5)22(33-4)10-16(18)20/h7-11,13H,6,12H2,1-5H3,(H2,28,29,30,31)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of CSF-1R


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50381929
PNG
(CHEMBL2023115)
Show SMILES CCn1cc(NC(=O)Cc2ccc(Oc3ncnc4cc(OC)c(OC)cc34)cc2OC)cn1
Show InChI InChI=1S/C24H25N5O5/c1-5-29-13-16(12-27-29)28-23(30)8-15-6-7-17(9-20(15)31-2)34-24-18-10-21(32-3)22(33-4)11-19(18)25-14-26-24/h6-7,9-14H,5,8H2,1-4H3,(H,28,30)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50381935
PNG
(CHEMBL2023475)
Show SMILES CCn1cc(NC(=O)Cc2ccc(Oc3ccnc4ccc(F)cc34)cc2OC)cn1
Show InChI InChI=1S/C23H21FN4O3/c1-3-28-14-17(13-26-28)27-23(29)10-15-4-6-18(12-22(15)30-2)31-21-8-9-25-20-7-5-16(24)11-19(20)21/h4-9,11-14H,3,10H2,1-2H3,(H,27,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of CSF-1R


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50381949
PNG
(CHEMBL2023118)
Show SMILES CCn1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)ccc34)cc2OC)cn1
Show InChI InChI=1S/C24H24N4O4/c1-4-28-15-17(14-26-28)27-24(29)11-16-5-6-19(13-23(16)31-3)32-22-9-10-25-21-12-18(30-2)7-8-20(21)22/h5-10,12-15H,4,11H2,1-3H3,(H,27,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of Flt3


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50381930
PNG
(CHEMBL2023495)
Show SMILES CCn1cc(NC(=O)Cc2ncc(Oc3ccnc4cc(OC)ccc34)cc2OC)cn1
Show InChI InChI=1S/C23H23N5O4/c1-4-28-14-15(12-26-28)27-23(29)11-20-22(31-3)10-17(13-25-20)32-21-7-8-24-19-9-16(30-2)5-6-18(19)21/h5-10,12-14H,4,11H2,1-3H3,(H,27,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of Flt3


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50381929
PNG
(CHEMBL2023115)
Show SMILES CCn1cc(NC(=O)Cc2ccc(Oc3ncnc4cc(OC)c(OC)cc34)cc2OC)cn1
Show InChI InChI=1S/C24H25N5O5/c1-5-29-13-16(12-27-29)28-23(30)8-15-6-7-17(9-20(15)31-2)34-24-18-10-21(32-3)22(33-4)11-19(18)25-14-26-24/h6-7,9-14H,5,8H2,1-4H3,(H,28,30)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of Flt3


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50381921
PNG
(CHEMBL2023480)
Show SMILES COc1cc(Oc2ccnc3cc(F)ccc23)ccc1CC(=O)Nc1noc(C)c1C
Show InChI InChI=1S/C23H20FN3O4/c1-13-14(2)31-27-23(13)26-22(28)10-15-4-6-17(12-21(15)29-3)30-20-8-9-25-19-11-16(24)5-7-18(19)20/h4-9,11-12H,10H2,1-3H3,(H,26,27,28)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of CSF-1R


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50381931
PNG
(CHEMBL2023476)
Show SMILES COc1ccc2c(Oc3ccc(CC(=O)Nc4ncc(C)s4)c(OC)c3)ccnc2c1
Show InChI InChI=1S/C23H21N3O4S/c1-14-13-25-23(31-14)26-22(27)10-15-4-5-17(12-21(15)29-3)30-20-8-9-24-19-11-16(28-2)6-7-18(19)20/h4-9,11-13H,10H2,1-3H3,(H,25,26,27)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of Flt3


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50381939
PNG
(CHEMBL2023488)
Show SMILES COc1cc(Oc2ccnc3cc(OC)c(OC)cc23)ccc1CC(=O)Nc1cn(C)nc1C
Show InChI InChI=1S/C25H26N4O5/c1-15-20(14-29(2)28-15)27-25(30)10-16-6-7-17(11-22(16)31-3)34-21-8-9-26-19-13-24(33-5)23(32-4)12-18(19)21/h6-9,11-14H,10H2,1-5H3,(H,27,30)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of Flt3


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50381924
PNG
(CHEMBL2023484)
Show SMILES CCc1cn[nH]c1NC(=O)Cc1ccc(Oc2ccnc3cc(OC)ccc23)cc1OC
Show InChI InChI=1S/C24H24N4O4/c1-4-15-14-26-28-24(15)27-23(29)11-16-5-6-18(13-22(16)31-3)32-21-9-10-25-20-12-17(30-2)7-8-19(20)21/h5-10,12-14H,4,11H2,1-3H3,(H2,26,27,28,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of Flt3


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50381943
PNG
(CHEMBL2023496)
Show SMILES COc1ccc2c(Oc3cnc(CC(=O)Nc4cn(C)nc4C)c(OC)c3)ccnc2c1
Show InChI InChI=1S/C23H23N5O4/c1-14-20(13-28(2)27-14)26-23(29)11-19-22(31-4)10-16(12-25-19)32-21-7-8-24-18-9-15(30-3)5-6-17(18)21/h5-10,12-13H,11H2,1-4H3,(H,26,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of Flt3


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50381941
PNG
(CHEMBL2023492)
Show SMILES COc1ccc2c(Oc3ccc(CC(=O)Nc4cnn(C)c4)c(OC)c3)ccnc2c1
Show InChI InChI=1S/C23H22N4O4/c1-27-14-16(13-25-27)26-23(28)10-15-4-5-18(12-22(15)30-3)31-21-8-9-24-20-11-17(29-2)6-7-19(20)21/h4-9,11-14H,10H2,1-3H3,(H,26,28)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of Flt3


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50381937
PNG
(CHEMBL2023479)
Show SMILES COc1ccc2nccc(Oc3ccc(CC(=O)Nc4noc(C)c4C)c(OC)c3)c2c1
Show InChI InChI=1S/C24H23N3O5/c1-14-15(2)32-27-24(14)26-23(28)11-16-5-6-18(13-22(16)30-4)31-21-9-10-25-20-8-7-17(29-3)12-19(20)21/h5-10,12-13H,11H2,1-4H3,(H,26,27,28)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of Flt3


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50381935
PNG
(CHEMBL2023475)
Show SMILES CCn1cc(NC(=O)Cc2ccc(Oc3ccnc4ccc(F)cc34)cc2OC)cn1
Show InChI InChI=1S/C23H21FN4O3/c1-3-28-14-17(13-26-28)27-23(29)10-15-4-6-18(12-22(15)30-2)31-21-8-9-25-20-7-5-16(24)11-19(20)21/h4-9,11-14H,3,10H2,1-2H3,(H,27,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of Flt3


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50381921
PNG
(CHEMBL2023480)
Show SMILES COc1cc(Oc2ccnc3cc(F)ccc23)ccc1CC(=O)Nc1noc(C)c1C
Show InChI InChI=1S/C23H20FN3O4/c1-13-14(2)31-27-23(13)26-22(28)10-15-4-6-17(12-21(15)29-3)30-20-8-9-25-19-11-16(24)5-7-18(19)20/h4-9,11-12H,10H2,1-3H3,(H,26,27,28)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of Flt3


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50381925
PNG
(CHEMBL2023481)
Show SMILES COc1cc(Oc2ccnc3ccc(F)cc23)ccc1CC(=O)Nc1noc(C)c1C
Show InChI InChI=1S/C23H20FN3O4/c1-13-14(2)31-27-23(13)26-22(28)10-15-4-6-17(12-21(15)29-3)30-20-8-9-25-19-7-5-16(24)11-18(19)20/h4-9,11-12H,10H2,1-3H3,(H,26,27,28)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of CSF-1R


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50381940
PNG
(CHEMBL2023491)
Show SMILES COc1ccc2c(Oc3ccc(CC(=O)Nc4cnn(C)c4C)c(OC)c3)ccnc2c1
Show InChI InChI=1S/C24H24N4O4/c1-15-21(14-26-28(15)2)27-24(29)11-16-5-6-18(13-23(16)31-4)32-22-9-10-25-20-12-17(30-3)7-8-19(20)22/h5-10,12-14H,11H2,1-4H3,(H,27,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of Flt3


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50381920
PNG
(CHEMBL2023119)
Show SMILES CCn1cc(NC(=O)Cc2ccc(Oc3ccnc4ccc(OC)cc34)cc2OC)cn1
Show InChI InChI=1S/C24H24N4O4/c1-4-28-15-17(14-26-28)27-24(29)11-16-5-6-19(13-23(16)31-3)32-22-9-10-25-21-8-7-18(30-2)12-20(21)22/h5-10,12-15H,4,11H2,1-3H3,(H,27,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of Flt3


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50381944
PNG
(CHEMBL2023801)
Show SMILES CCc1n[nH]c(NC(=O)Cc2ncc(Oc3ccnc4cc(OC)c(OC)cc34)cc2OC)c1C
Show InChI InChI=1S/C25H27N5O5/c1-6-17-14(2)25(30-29-17)28-24(31)12-19-21(32-3)9-15(13-27-19)35-20-7-8-26-18-11-23(34-5)22(33-4)10-16(18)20/h7-11,13H,6,12H2,1-5H3,(H2,28,29,30,31)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of Flt3


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50381933
PNG
(CHEMBL2023487)
Show SMILES COc1cc(Oc2ncnc3cc(OC)c(OC)cc23)ccc1CC(=O)Nc1cn(C)nc1C
Show InChI InChI=1S/C24H25N5O5/c1-14-19(12-29(2)28-14)27-23(30)8-15-6-7-16(9-20(15)31-3)34-24-17-10-21(32-4)22(33-5)11-18(17)25-13-26-24/h6-7,9-13H,8H2,1-5H3,(H,27,30)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of Flt3


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50381934
PNG
(CHEMBL2023474)
Show SMILES CCn1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(F)ccc34)cc2OC)cn1
Show InChI InChI=1S/C23H21FN4O3/c1-3-28-14-17(13-26-28)27-23(29)10-15-4-6-18(12-22(15)30-2)31-21-8-9-25-20-11-16(24)5-7-19(20)21/h4-9,11-14H,3,10H2,1-2H3,(H,27,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of Flt3


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50381933
PNG
(CHEMBL2023487)
Show SMILES COc1cc(Oc2ncnc3cc(OC)c(OC)cc23)ccc1CC(=O)Nc1cn(C)nc1C
Show InChI InChI=1S/C24H25N5O5/c1-14-19(12-29(2)28-14)27-23(30)8-15-6-7-16(9-20(15)31-3)34-24-17-10-21(32-4)22(33-5)11-18(17)25-13-26-24/h6-7,9-13H,8H2,1-5H3,(H,27,30)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of CSF-1R


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50381938
PNG
(CHEMBL2023483)
Show SMILES COc1ccc2c(Oc3ccc(CC(=O)Nc4[nH]nc(C)c4C)c(OC)c3)ccnc2c1
Show InChI InChI=1S/C24H24N4O4/c1-14-15(2)27-28-24(14)26-23(29)11-16-5-6-18(13-22(16)31-4)32-21-9-10-25-20-12-17(30-3)7-8-19(20)21/h5-10,12-13H,11H2,1-4H3,(H2,26,27,28,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of Flt3


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50381932
PNG
(CHEMBL2023116)
Show SMILES CCn1cc(NC(=O)Cc2ccc(Oc3ncnc4cc(OC)c(OC)cc34)c(OC)c2)cn1
Show InChI InChI=1S/C24H25N5O5/c1-5-29-13-16(12-27-29)28-23(30)9-15-6-7-19(20(8-15)31-2)34-24-17-10-21(32-3)22(33-4)11-18(17)25-14-26-24/h6-8,10-14H,5,9H2,1-4H3,(H,28,30)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of CSF-1R


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50381942
PNG
(CHEMBL2023493)
Show SMILES COc1ccc2c(Oc3ccc(CC(=O)Nc4cc(C)nn4C)c(OC)c3)ccnc2c1
Show InChI InChI=1S/C24H24N4O4/c1-15-11-23(28(2)27-15)26-24(29)12-16-5-6-18(14-22(16)31-4)32-21-9-10-25-20-13-17(30-3)7-8-19(20)21/h5-11,13-14H,12H2,1-4H3,(H,26,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of Flt3


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50381936
PNG
(CHEMBL2023478)
Show SMILES COc1ccc2c(Oc3ccc(CC(=O)Nc4noc(C)c4C)c(OC)c3)ccnc2c1
Show InChI InChI=1S/C24H23N3O5/c1-14-15(2)32-27-24(14)26-23(28)11-16-5-6-18(13-22(16)30-4)31-21-9-10-25-20-12-17(29-3)7-8-19(20)21/h5-10,12-13H,11H2,1-4H3,(H,26,27,28)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of Flt3


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50362090
PNG
(CHEMBL1940275)
Show SMILES COc1cc2ncnc(Nc3ccc(CC(=O)Nc4cnn(c4)C(C)C)cc3)c2cc1OC
Show InChI InChI=1S/C24H26N6O3/c1-15(2)30-13-18(12-27-30)28-23(31)9-16-5-7-17(8-6-16)29-24-19-10-21(32-3)22(33-4)11-20(19)25-14-26-24/h5-8,10-15H,9H2,1-4H3,(H,28,31)(H,25,26,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of CSF-1R


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50381925
PNG
(CHEMBL2023481)
Show SMILES COc1cc(Oc2ccnc3ccc(F)cc23)ccc1CC(=O)Nc1noc(C)c1C
Show InChI InChI=1S/C23H20FN3O4/c1-13-14(2)31-27-23(13)26-22(28)10-15-4-6-17(12-21(15)29-3)30-20-8-9-25-19-7-5-16(24)11-18(19)20/h4-9,11-12H,10H2,1-3H3,(H,26,27,28)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of Flt3


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50381924
PNG
(CHEMBL2023484)
Show SMILES CCc1cn[nH]c1NC(=O)Cc1ccc(Oc2ccnc3cc(OC)ccc23)cc1OC
Show InChI InChI=1S/C24H24N4O4/c1-4-15-14-26-28-24(15)27-23(29)11-16-5-6-18(13-22(16)31-3)32-21-9-10-25-20-12-17(30-2)7-8-19(20)21/h5-10,12-14H,4,11H2,1-3H3,(H2,26,27,28,29)
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n/an/a 1.28E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50381936
PNG
(CHEMBL2023478)
Show SMILES COc1ccc2c(Oc3ccc(CC(=O)Nc4noc(C)c4C)c(OC)c3)ccnc2c1
Show InChI InChI=1S/C24H23N3O5/c1-14-15(2)32-27-24(14)26-23(28)11-16-5-6-18(13-22(16)30-4)31-21-9-10-25-20-12-17(29-3)7-8-19(20)21/h5-10,12-13H,11H2,1-4H3,(H,26,27,28)
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n/an/a 1.62E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50381945
PNG
(CHEMBL2023477)
Show SMILES COc1cc(Oc2ccnc3cc(OC)c(OC)cc23)ccc1CC(=O)Nc1noc(C)c1C
Show InChI InChI=1S/C25H25N3O6/c1-14-15(2)34-28-25(14)27-24(29)10-16-6-7-17(11-21(16)30-3)33-20-8-9-26-19-13-23(32-5)22(31-4)12-18(19)20/h6-9,11-13H,10H2,1-5H3,(H,27,28,29)
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n/an/a 1.92E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50381920
PNG
(CHEMBL2023119)
Show SMILES CCn1cc(NC(=O)Cc2ccc(Oc3ccnc4ccc(OC)cc34)cc2OC)cn1
Show InChI InChI=1S/C24H24N4O4/c1-4-28-15-17(14-26-28)27-24(29)11-16-5-6-19(13-23(16)31-3)32-22-9-10-25-21-8-7-18(30-2)12-20(21)22/h5-10,12-15H,4,11H2,1-3H3,(H,27,29)
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n/an/a 2.07E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50381941
PNG
(CHEMBL2023492)
Show SMILES COc1ccc2c(Oc3ccc(CC(=O)Nc4cnn(C)c4)c(OC)c3)ccnc2c1
Show InChI InChI=1S/C23H22N4O4/c1-27-14-16(13-25-27)26-23(28)10-15-4-5-18(12-22(15)30-3)31-21-8-9-24-20-11-17(29-2)6-7-19(20)21/h4-9,11-14H,10H2,1-3H3,(H,26,28)
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n/an/a 2.48E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50381928
PNG
(CHEMBL2023802)
Show SMILES CCOc1cc2nccc(Oc3cnc(CC(=O)Nc4[nH]nc(CC)c4C)c(OC)c3)c2cc1OC
Show InChI InChI=1S/C26H29N5O5/c1-6-18-15(3)26(31-30-18)29-25(32)13-20-22(33-4)10-16(14-28-20)36-21-8-9-27-19-12-24(35-7-2)23(34-5)11-17(19)21/h8-12,14H,6-7,13H2,1-5H3,(H2,29,30,31,32)
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n/an/a 3.00E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of Flt3


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50381939
PNG
(CHEMBL2023488)
Show SMILES COc1cc(Oc2ccnc3cc(OC)c(OC)cc23)ccc1CC(=O)Nc1cn(C)nc1C
Show InChI InChI=1S/C25H26N4O5/c1-15-20(14-29(2)28-15)27-25(30)10-16-6-7-17(11-22(16)31-3)34-21-8-9-26-19-13-24(33-5)23(32-4)12-18(19)21/h6-9,11-14H,10H2,1-5H3,(H,27,30)
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n/an/a 3.95E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50381935
PNG
(CHEMBL2023475)
Show SMILES CCn1cc(NC(=O)Cc2ccc(Oc3ccnc4ccc(F)cc34)cc2OC)cn1
Show InChI InChI=1S/C23H21FN4O3/c1-3-28-14-17(13-26-28)27-23(29)10-15-4-6-18(12-22(15)30-2)31-21-8-9-25-20-7-5-16(24)11-19(20)21/h4-9,11-14H,3,10H2,1-2H3,(H,27,29)
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n/an/a 4.07E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50381934
PNG
(CHEMBL2023474)
Show SMILES CCn1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(F)ccc34)cc2OC)cn1
Show InChI InChI=1S/C23H21FN4O3/c1-3-28-14-17(13-26-28)27-23(29)10-15-4-6-18(12-22(15)30-2)31-21-8-9-25-20-11-16(24)5-7-19(20)21/h4-9,11-14H,3,10H2,1-2H3,(H,27,29)
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n/an/a 4.28E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50381930
PNG
(CHEMBL2023495)
Show SMILES CCn1cc(NC(=O)Cc2ncc(Oc3ccnc4cc(OC)ccc34)cc2OC)cn1
Show InChI InChI=1S/C23H23N5O4/c1-4-28-14-15(12-26-28)27-23(29)11-20-22(31-3)10-17(13-25-20)32-21-7-8-24-19-9-16(30-2)5-6-18(19)21/h5-10,12-14H,4,11H2,1-3H3,(H,27,29)
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n/an/a 4.72E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50381932
PNG
(CHEMBL2023116)
Show SMILES CCn1cc(NC(=O)Cc2ccc(Oc3ncnc4cc(OC)c(OC)cc34)c(OC)c2)cn1
Show InChI InChI=1S/C24H25N5O5/c1-5-29-13-16(12-27-29)28-23(30)9-15-6-7-19(20(8-15)31-2)34-24-17-10-21(32-3)22(33-4)11-18(17)25-14-26-24/h6-8,10-14H,5,9H2,1-4H3,(H,28,30)
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n/an/a 4.77E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50381928
PNG
(CHEMBL2023802)
Show SMILES CCOc1cc2nccc(Oc3cnc(CC(=O)Nc4[nH]nc(CC)c4C)c(OC)c3)c2cc1OC
Show InChI InChI=1S/C26H29N5O5/c1-6-18-15(3)26(31-30-18)29-25(32)13-20-22(33-4)10-16(14-28-20)36-21-8-9-27-19-12-24(35-7-2)23(34-5)11-17(19)21/h8-12,14H,6-7,13H2,1-5H3,(H2,29,30,31,32)
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n/an/a 4.82E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Cytochrome P450 2C9


(Homo sapiens (Human))
BDBM50381928
PNG
(CHEMBL2023802)
Show SMILES CCOc1cc2nccc(Oc3cnc(CC(=O)Nc4[nH]nc(CC)c4C)c(OC)c3)c2cc1OC
Show InChI InChI=1S/C26H29N5O5/c1-6-18-15(3)26(31-30-18)29-25(32)13-20-22(33-4)10-16(14-28-20)36-21-8-9-27-19-12-24(35-7-2)23(34-5)11-17(19)21/h8-12,14H,6-7,13H2,1-5H3,(H2,29,30,31,32)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of CYP2C9


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Cytochrome P450 1A


(Homo sapiens (Human))
BDBM50381928
PNG
(CHEMBL2023802)
Show SMILES CCOc1cc2nccc(Oc3cnc(CC(=O)Nc4[nH]nc(CC)c4C)c(OC)c3)c2cc1OC
Show InChI InChI=1S/C26H29N5O5/c1-6-18-15(3)26(31-30-18)29-25(32)13-20-22(33-4)10-16(14-28-20)36-21-8-9-27-19-12-24(35-7-2)23(34-5)11-17(19)21/h8-12,14H,6-7,13H2,1-5H3,(H2,29,30,31,32)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of CYP1A2


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Cytochrome P450 2C19


(Homo sapiens (Human))
BDBM50381928
PNG
(CHEMBL2023802)
Show SMILES CCOc1cc2nccc(Oc3cnc(CC(=O)Nc4[nH]nc(CC)c4C)c(OC)c3)c2cc1OC
Show InChI InChI=1S/C26H29N5O5/c1-6-18-15(3)26(31-30-18)29-25(32)13-20-22(33-4)10-16(14-28-20)36-21-8-9-27-19-12-24(35-7-2)23(34-5)11-17(19)21/h8-12,14H,6-7,13H2,1-5H3,(H2,29,30,31,32)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of CYP2C19


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (Human))
BDBM50381928
PNG
(CHEMBL2023802)
Show SMILES CCOc1cc2nccc(Oc3cnc(CC(=O)Nc4[nH]nc(CC)c4C)c(OC)c3)c2cc1OC
Show InChI InChI=1S/C26H29N5O5/c1-6-18-15(3)26(31-30-18)29-25(32)13-20-22(33-4)10-16(14-28-20)36-21-8-9-27-19-12-24(35-7-2)23(34-5)11-17(19)21/h8-12,14H,6-7,13H2,1-5H3,(H2,29,30,31,32)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of CYP3A4


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Cytochrome P450 2D6 (2D6)


(Homo sapiens (Human))
BDBM50381928
PNG
(CHEMBL2023802)
Show SMILES CCOc1cc2nccc(Oc3cnc(CC(=O)Nc4[nH]nc(CC)c4C)c(OC)c3)c2cc1OC
Show InChI InChI=1S/C26H29N5O5/c1-6-18-15(3)26(31-30-18)29-25(32)13-20-22(33-4)10-16(14-28-20)36-21-8-9-27-19-12-24(35-7-2)23(34-5)11-17(19)21/h8-12,14H,6-7,13H2,1-5H3,(H2,29,30,31,32)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of CYP2D6


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50381944
PNG
(CHEMBL2023801)
Show SMILES CCc1n[nH]c(NC(=O)Cc2ncc(Oc3ccnc4cc(OC)c(OC)cc34)cc2OC)c1C
Show InChI InChI=1S/C25H27N5O5/c1-6-17-14(2)25(30-29-17)28-24(31)12-19-21(32-3)9-15(13-27-19)35-20-7-8-26-18-11-23(34-5)22(33-4)10-16(18)20/h7-11,13H,6,12H2,1-5H3,(H2,28,29,30,31)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50381942
PNG
(CHEMBL2023493)
Show SMILES COc1ccc2c(Oc3ccc(CC(=O)Nc4cc(C)nn4C)c(OC)c3)ccnc2c1
Show InChI InChI=1S/C24H24N4O4/c1-15-11-23(28(2)27-15)26-24(29)12-16-5-6-18(14-22(16)31-4)32-21-9-10-25-20-13-17(30-3)7-8-19(20)21/h5-11,13-14H,12H2,1-4H3,(H,26,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Cytochrome P450 2C19


(Homo sapiens (Human))
BDBM50381926
PNG
(CHEMBL2023489 | CHEMBL2023803)
Show SMILES COc1ccc2c(Oc3ccc(CC(=O)Nc4cn(C)nc4C)c(OC)c3)ccnc2c1
Show InChI InChI=1S/C24H24N4O4/c1-15-21(14-28(2)27-15)26-24(29)11-16-5-6-18(13-23(16)31-4)32-22-9-10-25-20-12-17(30-3)7-8-19(20)22/h5-10,12-14H,11H2,1-4H3,(H,26,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of CYP2C19


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50381943
PNG
(CHEMBL2023496)
Show SMILES COc1ccc2c(Oc3cnc(CC(=O)Nc4cn(C)nc4C)c(OC)c3)ccnc2c1
Show InChI InChI=1S/C23H23N5O4/c1-14-20(13-28(2)27-14)26-23(29)11-19-22(31-4)10-16(12-25-19)32-21-7-8-24-18-9-15(30-3)5-6-17(18)21/h5-10,12-13H,11H2,1-4H3,(H,26,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (Human))
BDBM50381926
PNG
(CHEMBL2023489 | CHEMBL2023803)
Show SMILES COc1ccc2c(Oc3ccc(CC(=O)Nc4cn(C)nc4C)c(OC)c3)ccnc2c1
Show InChI InChI=1S/C24H24N4O4/c1-15-21(14-28(2)27-15)26-24(29)11-16-5-6-18(13-23(16)31-4)32-22-9-10-25-20-12-17(30-3)7-8-19(20)22/h5-10,12-14H,11H2,1-4H3,(H,26,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of CYP3A4


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50381921
PNG
(CHEMBL2023480)
Show SMILES COc1cc(Oc2ccnc3cc(F)ccc23)ccc1CC(=O)Nc1noc(C)c1C
Show InChI InChI=1S/C23H20FN3O4/c1-13-14(2)31-27-23(13)26-22(28)10-15-4-6-17(12-21(15)29-3)30-20-8-9-25-19-11-16(24)5-7-18(19)20/h4-9,11-12H,10H2,1-3H3,(H,26,27,28)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50381937
PNG
(CHEMBL2023479)
Show SMILES COc1ccc2nccc(Oc3ccc(CC(=O)Nc4noc(C)c4C)c(OC)c3)c2c1
Show InChI InChI=1S/C24H23N3O5/c1-14-15(2)32-27-24(14)26-23(28)11-16-5-6-18(13-22(16)30-4)31-21-9-10-25-20-8-7-17(29-3)12-19(20)21/h5-10,12-13H,11H2,1-4H3,(H,26,27,28)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Cytochrome P450 1A


(Homo sapiens (Human))
BDBM50381926
PNG
(CHEMBL2023489 | CHEMBL2023803)
Show SMILES COc1ccc2c(Oc3ccc(CC(=O)Nc4cn(C)nc4C)c(OC)c3)ccnc2c1
Show InChI InChI=1S/C24H24N4O4/c1-15-21(14-28(2)27-15)26-24(29)11-16-5-6-18(13-23(16)31-4)32-22-9-10-25-20-12-17(30-3)7-8-19(20)22/h5-10,12-14H,11H2,1-4H3,(H,26,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of CYP1A2


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50381933
PNG
(CHEMBL2023487)
Show SMILES COc1cc(Oc2ncnc3cc(OC)c(OC)cc23)ccc1CC(=O)Nc1cn(C)nc1C
Show InChI InChI=1S/C24H25N5O5/c1-14-19(12-29(2)28-14)27-23(30)8-15-6-7-16(9-20(15)31-3)34-24-17-10-21(32-4)22(33-5)11-18(17)25-13-26-24/h6-7,9-13H,8H2,1-5H3,(H,27,30)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50381940
PNG
(CHEMBL2023491)
Show SMILES COc1ccc2c(Oc3ccc(CC(=O)Nc4cnn(C)c4C)c(OC)c3)ccnc2c1
Show InChI InChI=1S/C24H24N4O4/c1-15-21(14-26-28(15)2)27-24(29)11-16-5-6-18(13-23(16)31-4)32-22-9-10-25-20-12-17(30-3)7-8-19(20)22/h5-10,12-14H,11H2,1-4H3,(H,27,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50381925
PNG
(CHEMBL2023481)
Show SMILES COc1cc(Oc2ccnc3ccc(F)cc23)ccc1CC(=O)Nc1noc(C)c1C
Show InChI InChI=1S/C23H20FN3O4/c1-13-14(2)31-27-23(13)26-22(28)10-15-4-6-17(12-21(15)29-3)30-20-8-9-25-19-7-5-16(24)11-18(19)20/h4-9,11-12H,10H2,1-3H3,(H,26,27,28)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Cytochrome P450 2D6 (2D6)


(Homo sapiens (Human))
BDBM50381926
PNG
(CHEMBL2023489 | CHEMBL2023803)
Show SMILES COc1ccc2c(Oc3ccc(CC(=O)Nc4cn(C)nc4C)c(OC)c3)ccnc2c1
Show InChI InChI=1S/C24H24N4O4/c1-15-21(14-28(2)27-15)26-24(29)11-16-5-6-18(13-23(16)31-4)32-22-9-10-25-20-12-17(30-3)7-8-19(20)22/h5-10,12-14H,11H2,1-4H3,(H,26,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of CYP2D6


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Cytochrome P450 2C9


(Homo sapiens (Human))
BDBM50381926
PNG
(CHEMBL2023489 | CHEMBL2023803)
Show SMILES COc1ccc2c(Oc3ccc(CC(=O)Nc4cn(C)nc4C)c(OC)c3)ccnc2c1
Show InChI InChI=1S/C24H24N4O4/c1-15-21(14-28(2)27-15)26-24(29)11-16-5-6-18(13-23(16)31-4)32-22-9-10-25-20-12-17(30-3)7-8-19(20)22/h5-10,12-14H,11H2,1-4H3,(H,26,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of CYP2C9


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50381926
PNG
(CHEMBL2023489 | CHEMBL2023803)
Show SMILES COc1ccc2c(Oc3ccc(CC(=O)Nc4cn(C)nc4C)c(OC)c3)ccnc2c1
Show InChI InChI=1S/C24H24N4O4/c1-15-21(14-28(2)27-15)26-24(29)11-16-5-6-18(13-23(16)31-4)32-22-9-10-25-20-12-17(30-3)7-8-19(20)22/h5-10,12-14H,11H2,1-4H3,(H,26,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50381926
PNG
(CHEMBL2023489 | CHEMBL2023803)
Show SMILES COc1ccc2c(Oc3ccc(CC(=O)Nc4cn(C)nc4C)c(OC)c3)ccnc2c1
Show InChI InChI=1S/C24H24N4O4/c1-15-21(14-28(2)27-15)26-24(29)11-16-5-6-18(13-23(16)31-4)32-22-9-10-25-20-12-17(30-3)7-8-19(20)22/h5-10,12-14H,11H2,1-4H3,(H,26,29)
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n/an/a>2.00E+4n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of Flt3


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50381928
PNG
(CHEMBL2023802)
Show SMILES CCOc1cc2nccc(Oc3cnc(CC(=O)Nc4[nH]nc(CC)c4C)c(OC)c3)c2cc1OC
Show InChI InChI=1S/C26H29N5O5/c1-6-18-15(3)26(31-30-18)29-25(32)13-20-22(33-4)10-16(14-28-20)36-21-8-9-27-19-12-24(35-7-2)23(34-5)11-17(19)21/h8-12,14H,6-7,13H2,1-5H3,(H2,29,30,31,32)
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n/an/a 7.60E+4n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human ERG


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50381926
PNG
(CHEMBL2023489 | CHEMBL2023803)
Show SMILES COc1ccc2c(Oc3ccc(CC(=O)Nc4cn(C)nc4C)c(OC)c3)ccnc2c1
Show InChI InChI=1S/C24H24N4O4/c1-15-21(14-28(2)27-15)26-24(29)11-16-5-6-18(13-23(16)31-4)32-22-9-10-25-20-12-17(30-3)7-8-19(20)22/h5-10,12-14H,11H2,1-4H3,(H,26,29)
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n/an/a>1.00E+5n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human ERG


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%