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USPatent US10285983

Compile data set for download or QSAR
Found 70 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384734
PNG
(US10285983, Compound 59)
Show SMILES Nc1cncc(c1)-c1cnc2[nH]nc(-c3cc4c(ccnc4[nH]3)-c3ccccc3F)c2c1
Show InChI InChI=1S/C24H16FN7/c25-20-4-2-1-3-17(20)16-5-6-28-23-18(16)9-21(30-23)22-19-8-14(11-29-24(19)32-31-22)13-7-15(26)12-27-10-13/h1-12H,26H2,(H,28,30)(H,29,31,32)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384736
PNG
(US10285983, Compound 63)
Show SMILES CN(C)c1cncc(c1)-c1cnc2[nH]nc(-c3cc4c(ccnc4[nH]3)-c3ccccc3F)c2c1
Show InChI InChI=1S/C26H20FN7/c1-34(2)17-9-15(12-28-14-17)16-10-21-24(32-33-26(21)30-13-16)23-11-20-18(7-8-29-25(20)31-23)19-5-3-4-6-22(19)27/h3-14H,1-2H3,(H,29,31)(H,30,32,33)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384743
PNG
(US10285983, Compound 88)
Show SMILES c1c([nH]c2nccc(-c3cccnc3)c12)-c1n[nH]c2ncc(cc12)-c1cccnc1
Show InChI InChI=1S/C23H15N7/c1-3-14(11-24-6-1)16-9-19-21(29-30-23(19)27-13-16)20-10-18-17(5-8-26-22(18)28-20)15-4-2-7-25-12-15/h1-13H,(H,26,28)(H,27,29,30)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384749
PNG
(US10285983, Compound 104)
Show SMILES O=C(Nc1cncc(c1)-c1cnc2[nH]nc(-c3cc4c(ccnc4[nH]3)-c3cccnc3)c2c1)C1CC1
Show InChI InChI=1S/C27H20N8O/c36-27(15-3-4-15)32-19-8-17(12-29-14-19)18-9-22-24(34-35-26(22)31-13-18)23-10-21-20(5-7-30-25(21)33-23)16-2-1-6-28-11-16/h1-2,5-15H,3-4H2,(H,30,33)(H,32,36)(H,31,34,35)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384756
PNG
(US10285983, Compound 135)
Show SMILES O=C(Nc1cncc(c1)-c1cnc2[nH]nc(-c3cc4c(ccnc4[nH]3)-c3ccncc3)c2c1)C1CCCCC1
Show InChI InChI=1S/C30H26N8O/c39-30(19-4-2-1-3-5-19)35-22-12-20(15-32-17-22)21-13-25-27(37-38-29(25)34-16-21)26-14-24-23(8-11-33-28(24)36-26)18-6-9-31-10-7-18/h6-17,19H,1-5H2,(H,33,36)(H,35,39)(H,34,37,38)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384758
PNG
(US10285983, Compound 140)
Show SMILES c1c([nH]c2nccc(-c3ccncc3)c12)-c1n[nH]c2ncc(cc12)-c1ccccn1
Show InChI InChI=1S/C23H15N7/c1-2-7-25-19(3-1)15-11-18-21(29-30-23(18)27-13-15)20-12-17-16(6-10-26-22(17)28-20)14-4-8-24-9-5-14/h1-13H,(H,26,28)(H,27,29,30)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384762
PNG
(US10285983, Compound 182)
Show SMILES C(N1CCCC1)c1cncc(c1)-c1cnc2[nH]nc(-c3cc4c(ccnc4[nH]3)N3CCCCC3)c2c1
Show InChI InChI=1S/C28H30N8/c1-2-10-36(11-3-1)25-6-7-30-27-22(25)14-24(32-27)26-23-13-21(17-31-28(23)34-33-26)20-12-19(15-29-16-20)18-35-8-4-5-9-35/h6-7,12-17H,1-5,8-11,18H2,(H,30,32)(H,31,33,34)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384767
PNG
(US10285983, Compound 256)
Show SMILES c1c([nH]c2ncccc12)-c1n[nH]c2ncc(cc12)-c1cccnc1
Show InChI InChI=1S/C18H12N6/c1-4-12(9-19-5-1)13-7-14-16(23-24-18(14)21-10-13)15-8-11-3-2-6-20-17(11)22-15/h1-10H,(H,20,22)(H,21,23,24)
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n/an/an/an/a 1.07E+3n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384720
PNG
(US10285983, Compound 11)
Show SMILES Fc1cccc(c1)-c1ccnc2[nH]c(cc12)-c1n[nH]c2ncc(cc12)-c1cncc(NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C31H20FN7O/c32-22-8-4-7-19(11-22)24-9-10-34-29-25(24)14-27(37-29)28-26-13-21(16-35-30(26)39-38-28)20-12-23(17-33-15-20)36-31(40)18-5-2-1-3-6-18/h1-17H,(H,34,37)(H,36,40)(H,35,38,39)
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Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384723
PNG
(US10285983, Compound 20)
Show SMILES Fc1cccc(c1)-c1ccnc2[nH]c(cc12)-c1n[nH]c2ncc(cc12)-c1cncc(NC(=O)C2CC2)c1
Show InChI InChI=1S/C28H20FN7O/c29-19-3-1-2-16(8-19)21-6-7-31-26-22(21)11-24(34-26)25-23-10-18(13-32-27(23)36-35-25)17-9-20(14-30-12-17)33-28(37)15-4-5-15/h1-3,6-15H,4-5H2,(H,31,34)(H,33,37)(H,32,35,36)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384733
PNG
(US10285983, Compound 55)
Show SMILES Fc1ccc(cc1)-c1ccnc2[nH]c(cc12)-c1n[nH]c2ncc(cc12)-c1cncnc1
Show InChI InChI=1S/C23H14FN7/c24-16-3-1-13(2-4-16)17-5-6-27-22-18(17)8-20(29-22)21-19-7-14(11-28-23(19)31-30-21)15-9-25-12-26-10-15/h1-12H,(H,27,29)(H,28,30,31)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384740
PNG
(US10285983, Compound 75)
Show SMILES CCCCC(=O)Nc1cncc(c1)-c1cnc2[nH]nc(-c3cc4c(ccnc4[nH]3)-c3ccccc3F)c2c1
Show InChI InChI=1S/C29H24FN7O/c1-2-3-8-26(38)34-19-11-17(14-31-16-19)18-12-23-27(36-37-29(23)33-15-18)25-13-22-20(9-10-32-28(22)35-25)21-6-4-5-7-24(21)30/h4-7,9-16H,2-3,8H2,1H3,(H,32,35)(H,34,38)(H,33,36,37)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384751
PNG
(US10285983, Compound 117)
Show SMILES Cc1ccncc1-c1cnc2[nH]nc(-c3cc4c(ccnc4[nH]3)-c3ccncc3)c2c1
Show InChI InChI=1S/C24H17N7/c1-14-2-6-26-13-20(14)16-10-19-22(30-31-24(19)28-12-16)21-11-18-17(5-9-27-23(18)29-21)15-3-7-25-8-4-15/h2-13H,1H3,(H,27,29)(H,28,30,31)
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Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384772
PNG
(US10285983, Compound 274)
Show SMILES O=C(Nc1cncc(c1)-c1cnc2[nH]nc(-c3cc4cccnc4[nH]3)c2c1)C1CCCC1
Show InChI InChI=1S/C24H21N7O/c32-24(14-4-1-2-5-14)28-18-8-16(11-25-13-18)17-9-19-21(30-31-23(19)27-12-17)20-10-15-6-3-7-26-22(15)29-20/h3,6-14H,1-2,4-5H2,(H,26,29)(H,28,32)(H,27,30,31)
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Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384774
PNG
(US10285983, Compound 324)
Show SMILES CC(C)(C)CC(=O)Nc1cncc(c1)-c1cnc2[nH]nc(-c3cc4c(ccnc4[nH]3)-c3ccoc3)c2c1
Show InChI InChI=1S/C28H25N7O2/c1-28(2,3)11-24(36)32-19-8-17(12-29-14-19)18-9-22-25(34-35-27(22)31-13-18)23-10-21-20(16-5-7-37-15-16)4-6-30-26(21)33-23/h4-10,12-15H,11H2,1-3H3,(H,30,33)(H,32,36)(H,31,34,35)
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Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384785
PNG
(US10285983, Compound 652)
Show SMILES Cn1cc(cn1)-c1cnc2[nH]nc(-c3cc4cccnc4[nH]3)c2c1
Show InChI InChI=1S/C17H13N7/c1-24-9-12(8-20-24)11-5-13-15(22-23-17(13)19-7-11)14-6-10-3-2-4-18-16(10)21-14/h2-9H,1H3,(H,18,21)(H,19,22,23)
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Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384719
PNG
(US10285983, Compound 4)
Show SMILES Fc1cccc(c1)-c1ccnc2[nH]c(cc12)-c1n[nH]c2ncc(cc12)-c1cccnc1
Show InChI InChI=1S/C24H15FN6/c25-17-5-1-3-14(9-17)18-6-8-27-23-19(18)11-21(29-23)22-20-10-16(13-28-24(20)31-30-22)15-4-2-7-26-12-15/h1-13H,(H,27,29)(H,28,30,31)
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Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384729
PNG
(US10285983, Compound 42)
Show SMILES Fc1ccc(cc1)-c1ccnc2[nH]c(cc12)-c1n[nH]c2ncc(cc12)-c1cncc(CN2CCCC2)c1
Show InChI InChI=1S/C29H24FN7/c30-22-5-3-19(4-6-22)23-7-8-32-28-24(23)13-26(34-28)27-25-12-21(16-33-29(25)36-35-27)20-11-18(14-31-15-20)17-37-9-1-2-10-37/h3-8,11-16H,1-2,9-10,17H2,(H,32,34)(H,33,35,36)
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Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384738
PNG
(US10285983, Compound 68)
Show SMILES CC(C)Nc1cncc(c1)-c1cnc2[nH]nc(-c3cc4c(ccnc4[nH]3)-c3ccccc3F)c2c1
Show InChI InChI=1S/C27H22FN7/c1-15(2)32-18-9-16(12-29-14-18)17-10-22-25(34-35-27(22)31-13-17)24-11-21-19(7-8-30-26(21)33-24)20-5-3-4-6-23(20)28/h3-15,32H,1-2H3,(H,30,33)(H,31,34,35)
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Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384744
PNG
(US10285983, Compound 90)
Show SMILES CCNCc1cncc(c1)-c1cnc2[nH]nc(-c3cc4c(ccnc4[nH]3)-c3cccnc3)c2c1
Show InChI InChI=1S/C26H22N8/c1-2-27-11-16-8-18(14-29-12-16)19-9-22-24(33-34-26(22)31-15-19)23-10-21-20(5-7-30-25(21)32-23)17-4-3-6-28-13-17/h3-10,12-15,27H,2,11H2,1H3,(H,30,32)(H,31,33,34)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384752
PNG
(US10285983, Compound 123)
Show SMILES O=C(Nc1cncc(c1)-c1cnc2[nH]nc(-c3cc4c(ccnc4[nH]3)-c3ccncc3)c2c1)c1ccccc1
Show InChI InChI=1S/C30H20N8O/c39-30(19-4-2-1-3-5-19)35-22-12-20(15-32-17-22)21-13-25-27(37-38-29(25)34-16-21)26-14-24-23(8-11-33-28(24)36-26)18-6-9-31-10-7-18/h1-17H,(H,33,36)(H,35,39)(H,34,37,38)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384753
PNG
(US10285983, Compound 128)
Show SMILES CC(C)(C)CC(=O)Nc1cncc(c1)-c1cnc2[nH]nc(-c3cc4c(ccnc4[nH]3)-c3ccncc3)c2c1
Show InChI InChI=1S/C29H26N8O/c1-29(2,3)13-25(38)34-20-10-18(14-31-16-20)19-11-23-26(36-37-28(23)33-15-19)24-12-22-21(6-9-32-27(22)35-24)17-4-7-30-8-5-17/h4-12,14-16H,13H2,1-3H3,(H,32,35)(H,34,38)(H,33,36,37)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384754
PNG
(US10285983, Compound 129)
Show SMILES CCCC(=O)Nc1cncc(c1)-c1cnc2[nH]nc(-c3cc4c(ccnc4[nH]3)-c3ccncc3)c2c1
Show InChI InChI=1S/C27H22N8O/c1-2-3-24(36)32-19-10-17(13-29-15-19)18-11-22-25(34-35-27(22)31-14-18)23-12-21-20(6-9-30-26(21)33-23)16-4-7-28-8-5-16/h4-15H,2-3H2,1H3,(H,30,33)(H,32,36)(H,31,34,35)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384761
PNG
(US10285983, Compound 181)
Show SMILES CN(C)Cc1cncc(c1)-c1cnc2[nH]nc(-c3cc4c(ccnc4[nH]3)N3CCCCC3)c2c1
Show InChI InChI=1S/C26H28N8/c1-33(2)16-17-10-18(14-27-13-17)19-11-21-24(31-32-26(21)29-15-19)22-12-20-23(6-7-28-25(20)30-22)34-8-4-3-5-9-34/h6-7,10-15H,3-5,8-9,16H2,1-2H3,(H,28,30)(H,29,31,32)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384765
PNG
(US10285983, Compound 195)
Show SMILES C1CCN(CC1)c1ccnc2[nH]c(cc12)-c1n[nH]c2ncc(cc12)-c1cncnc1
Show InChI InChI=1S/C22H20N8/c1-2-6-30(7-3-1)19-4-5-25-21-16(19)9-18(27-21)20-17-8-14(12-26-22(17)29-28-20)15-10-23-13-24-11-15/h4-5,8-13H,1-3,6-7H2,(H,25,27)(H,26,28,29)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384766
PNG
(US10285983, Compound 247)
Show SMILES CN1CCN(CC1)c1ccnc2[nH]c(cc12)-c1n[nH]c2ncc(cc12)-c1cncc(NC(=O)C2CCCCC2)c1
Show InChI InChI=1S/C30H33N9O/c1-38-9-11-39(12-10-38)26-7-8-32-28-23(26)15-25(35-28)27-24-14-21(17-33-29(24)37-36-27)20-13-22(18-31-16-20)34-30(40)19-5-3-2-4-6-19/h7-8,13-19H,2-6,9-12H2,1H3,(H,32,35)(H,34,40)(H,33,36,37)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384771
PNG
(US10285983, Compound 271)
Show SMILES CCCCC(=O)Nc1cncc(c1)-c1cnc2[nH]nc(-c3cc4cccnc4[nH]3)c2c1
Show InChI InChI=1S/C23H21N7O/c1-2-3-6-20(31)27-17-8-15(11-24-13-17)16-9-18-21(29-30-23(18)26-12-16)19-10-14-5-4-7-25-22(14)28-19/h4-5,7-13H,2-3,6H2,1H3,(H,25,28)(H,27,31)(H,26,29,30)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384778
PNG
(US10285983, Compound 469)
Show SMILES CN(C)CCNc1cc(F)cc(c1)-c1ccnc2[nH]c(cc12)-c1n[nH]c2ncc(cc12)-c1cncc(NC(=O)C2CCC2)c1
Show InChI InChI=1S/C33H32FN9O/c1-43(2)9-8-36-24-11-20(10-23(34)14-24)26-6-7-37-31-27(26)15-29(40-31)30-28-13-22(17-38-32(28)42-41-30)21-12-25(18-35-16-21)39-33(44)19-4-3-5-19/h6-7,10-19,36H,3-5,8-9H2,1-2H3,(H,37,40)(H,39,44)(H,38,41,42)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384721
PNG
(US10285983, Compound 13)
Show SMILES CN(C)Cc1cncc(c1)-c1cnc2[nH]nc(-c3cc4c(ccnc4[nH]3)-c3cccc(F)c3)c2c1
Show InChI InChI=1S/C27H22FN7/c1-35(2)15-16-8-18(13-29-12-16)19-10-23-25(33-34-27(23)31-14-19)24-11-22-21(6-7-30-26(22)32-24)17-4-3-5-20(28)9-17/h3-14H,15H2,1-2H3,(H,30,32)(H,31,33,34)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384750
PNG
(US10285983, Compound 115)
Show SMILES Nc1cncc(c1)-c1cnc2[nH]nc(-c3cc4c(ccnc4[nH]3)-c3ccncc3)c2c1
Show InChI InChI=1S/C23H16N8/c24-16-7-14(10-26-12-16)15-8-19-21(30-31-23(19)28-11-15)20-9-18-17(3-6-27-22(18)29-20)13-1-4-25-5-2-13/h1-12H,24H2,(H,27,29)(H,28,30,31)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384763
PNG
(US10285983, Compound 185)
Show SMILES CCCC(=O)Nc1cncc(c1)-c1cnc2[nH]nc(-c3cc4c(ccnc4[nH]3)N3CCCCC3)c2c1
Show InChI InChI=1S/C27H28N8O/c1-2-6-24(36)31-19-11-17(14-28-16-19)18-12-21-25(33-34-27(21)30-15-18)22-13-20-23(7-8-29-26(20)32-22)35-9-4-3-5-10-35/h7-8,11-16H,2-6,9-10H2,1H3,(H,29,32)(H,31,36)(H,30,33,34)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384770
PNG
(US10285983, Compound 270)
Show SMILES c1c([nH]c2ncccc12)-c1n[nH]c2ncc(cc12)-c1ccncc1
Show InChI InChI=1S/C18H12N6/c1-2-12-9-15(22-17(12)20-5-1)16-14-8-13(10-21-18(14)24-23-16)11-3-6-19-7-4-11/h1-10H,(H,20,22)(H,21,23,24)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384783
PNG
(US10285983, Compound 601)
Show SMILES C1CCN(CC1)c1ccnc2[nH]c(cc12)-c1n[nH]c2ncc(cc12)C1CCNCC1
Show InChI InChI=1S/C23H27N7/c1-2-10-30(11-3-1)20-6-9-25-22-17(20)13-19(27-22)21-18-12-16(14-26-23(18)29-28-21)15-4-7-24-8-5-15/h6,9,12-15,24H,1-5,7-8,10-11H2,(H,25,27)(H,26,28,29)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384784
PNG
(US10285983, Compound 635)
Show SMILES CN1CCN(CC1)c1ccnc2[nH]c(cc12)-c1n[nH]c2ncc(cc12)-c1cn[nH]c1
Show InChI InChI=1S/C21H21N9/c1-29-4-6-30(7-5-29)18-2-3-22-20-15(18)9-17(26-20)19-16-8-13(14-11-24-25-12-14)10-23-21(16)28-27-19/h2-3,8-12H,4-7H2,1H3,(H,22,26)(H,24,25)(H,23,27,28)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384718
PNG
(US10285983, Compound 1)
Show SMILES CCC(=O)Nc1cncc(c1)-c1cnc2[nH]nc(-c3cc4c(ccnc4[nH]3)-c3cccc(F)c3)c2c1
Show InChI InChI=1S/C27H20FN7O/c1-2-24(36)32-19-9-16(12-29-14-19)17-10-22-25(34-35-27(22)31-13-17)23-11-21-20(6-7-30-26(21)33-23)15-4-3-5-18(28)8-15/h3-14H,2H2,1H3,(H,30,33)(H,32,36)(H,31,34,35)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384725
PNG
(US10285983, Compound 28)
Show SMILES Fc1cccc(c1)-c1ccnc2[nH]c(cc12)-c1n[nH]c2ncc(cc12)-c1ccccn1
Show InChI InChI=1S/C24H15FN6/c25-16-5-3-4-14(10-16)17-7-9-27-23-18(17)12-21(29-23)22-19-11-15(13-28-24(19)31-30-22)20-6-1-2-8-26-20/h1-13H,(H,27,29)(H,28,30,31)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384727
PNG
(US10285983, Compound 33)
Show SMILES Cc1ccncc1-c1cnc2[nH]nc(-c3cc4c(ccnc4[nH]3)-c3ccc(F)cc3)c2c1
Show InChI InChI=1S/C25H17FN6/c1-14-6-8-27-13-21(14)16-10-20-23(31-32-25(20)29-12-16)22-11-19-18(7-9-28-24(19)30-22)15-2-4-17(26)5-3-15/h2-13H,1H3,(H,28,30)(H,29,31,32)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384748
PNG
(US10285983, Compound 99)
Show SMILES C(N1CCCCC1)c1cncc(c1)-c1cnc2[nH]nc(-c3cc4c(ccnc4[nH]3)-c3cccnc3)c2c1
Show InChI InChI=1S/C29H26N8/c1-2-9-37(10-3-1)18-19-11-21(16-31-14-19)22-12-25-27(35-36-29(25)33-17-22)26-13-24-23(6-8-32-28(24)34-26)20-5-4-7-30-15-20/h4-8,11-17H,1-3,9-10,18H2,(H,32,34)(H,33,35,36)
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Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384769
PNG
(US10285983, Compound 268)
Show SMILES CC(C)(C)CC(=O)Nc1cncc(c1)-c1cnc2[nH]nc(-c3cc4cccnc4[nH]3)c2c1
Show InChI InChI=1S/C24H23N7O/c1-24(2,3)10-20(32)28-17-7-15(11-25-13-17)16-8-18-21(30-31-23(18)27-12-16)19-9-14-5-4-6-26-22(14)29-19/h4-9,11-13H,10H2,1-3H3,(H,26,29)(H,28,32)(H,27,30,31)
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n/an/an/an/a 860n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384776
PNG
(US10285983, Compound 356)
Show SMILES O=C(Nc1cncc(c1)-c1cnc2[nH]nc(-c3cc4c(ccnc4[nH]3)-c3cccs3)c2c1)C1CC1
Show InChI InChI=1S/C26H19N7OS/c34-26(14-3-4-14)30-17-8-15(11-27-13-17)16-9-20-23(32-33-25(20)29-12-16)21-10-19-18(22-2-1-7-35-22)5-6-28-24(19)31-21/h1-2,5-14H,3-4H2,(H,28,31)(H,30,34)(H,29,32,33)
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n/an/an/an/a 6.37E+3n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384779
PNG
(US10285983, Compound 518)
Show SMILES Fc1cccc(c1)-c1ccnc2[nH]c(cc12)-c1n[nH]c2ncc(cc12)-c1cncc(OCc2ccccc2)c1
Show InChI InChI=1S/C31H21FN6O/c32-23-8-4-7-20(11-23)25-9-10-34-30-26(25)14-28(36-30)29-27-13-22(16-35-31(27)38-37-29)21-12-24(17-33-15-21)39-18-19-5-2-1-3-6-19/h1-17H,18H2,(H,34,36)(H,35,37,38)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384782
PNG
(US10285983, Compound 577)
Show SMILES O=C(CC1CCNCC1)Nc1cncc(c1)-c1cnc2[nH]nc(-c3cc4c(ccnc4[nH]3)-c3ccncc3)c2c1
Show InChI InChI=1S/C30H27N9O/c40-27(11-18-1-6-31-7-2-18)36-22-12-20(15-33-17-22)21-13-25-28(38-39-30(25)35-16-21)26-14-24-23(5-10-34-29(24)37-26)19-3-8-32-9-4-19/h3-5,8-10,12-18,31H,1-2,6-7,11H2,(H,34,37)(H,36,40)(H,35,38,39)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384726
PNG
(US10285983, Compound 30)
Show SMILES CC(C)CC(=O)Nc1cncc(c1)-c1cnc2[nH]nc(-c3cc4c(ccnc4[nH]3)-c3ccc(F)cc3)c2c1
Show InChI InChI=1S/C29H24FN7O/c1-16(2)9-26(38)34-21-10-18(13-31-15-21)19-11-24-27(36-37-29(24)33-14-19)25-12-23-22(7-8-32-28(23)35-25)17-3-5-20(30)6-4-17/h3-8,10-16H,9H2,1-2H3,(H,32,35)(H,34,38)(H,33,36,37)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384730
PNG
(US10285983, Compound 43)
Show SMILES Fc1ccc(cc1)-c1ccnc2[nH]c(cc12)-c1n[nH]c2ncc(cc12)-c1cncc(CN2CCCCC2)c1
Show InChI InChI=1S/C30H26FN7/c31-23-6-4-20(5-7-23)24-8-9-33-29-25(24)14-27(35-29)28-26-13-22(17-34-30(26)37-36-28)21-12-19(15-32-16-21)18-38-10-2-1-3-11-38/h4-9,12-17H,1-3,10-11,18H2,(H,33,35)(H,34,36,37)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384737
PNG
(US10285983, Compound 65)
Show SMILES CC(C)C(=O)Nc1cncc(c1)-c1cnc2[nH]nc(-c3cc4c(ccnc4[nH]3)-c3ccccc3F)c2c1
Show InChI InChI=1S/C28H22FN7O/c1-15(2)28(37)33-18-9-16(12-30-14-18)17-10-22-25(35-36-27(22)32-13-17)24-11-21-19(7-8-31-26(21)34-24)20-5-3-4-6-23(20)29/h3-15H,1-2H3,(H,31,34)(H,33,37)(H,32,35,36)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384741
PNG
(US10285983, Compound 78)
Show SMILES Fc1ccccc1-c1ccnc2[nH]c(cc12)-c1n[nH]c2ncc(cc12)-c1cncc(NC(=O)C2CCCC2)c1
Show InChI InChI=1S/C30H24FN7O/c31-25-8-4-3-7-22(25)21-9-10-33-28-23(21)13-26(36-28)27-24-12-19(15-34-29(24)38-37-27)18-11-20(16-32-14-18)35-30(39)17-5-1-2-6-17/h3-4,7-17H,1-2,5-6H2,(H,33,36)(H,35,39)(H,34,37,38)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384742
PNG
(US10285983, Compound 86)
Show SMILES CC(C)CC(=O)Nc1cncc(c1)-c1cnc2[nH]nc(-c3cc4c(ccnc4[nH]3)-c3cccnc3)c2c1
Show InChI InChI=1S/C28H24N8O/c1-16(2)8-25(37)33-20-9-18(13-30-15-20)19-10-23-26(35-36-28(23)32-14-19)24-11-22-21(5-7-31-27(22)34-24)17-4-3-6-29-12-17/h3-7,9-16H,8H2,1-2H3,(H,31,34)(H,33,37)(H,32,35,36)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384746
PNG
(US10285983, Compound 96)
Show SMILES CC(C)Nc1cncc(c1)-c1cnc2[nH]nc(-c3cc4c(ccnc4[nH]3)-c3cccnc3)c2c1
Show InChI InChI=1S/C26H22N8/c1-15(2)31-19-8-17(12-28-14-19)18-9-22-24(33-34-26(22)30-13-18)23-10-21-20(5-7-29-25(21)32-23)16-4-3-6-27-11-16/h3-15,31H,1-2H3,(H,29,32)(H,30,33,34)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384760
PNG
(US10285983, Compound 176)
Show SMILES CC(C)(C)C(=O)Nc1cncc(c1)-c1cnc2[nH]nc(-c3cc4c(ccnc4[nH]3)N3CCCCC3)c2c1
Show InChI InChI=1S/C28H30N8O/c1-28(2,3)27(37)32-19-11-17(14-29-16-19)18-12-21-24(34-35-26(21)31-15-18)22-13-20-23(7-8-30-25(20)33-22)36-9-5-4-6-10-36/h7-8,11-16H,4-6,9-10H2,1-3H3,(H,30,33)(H,32,37)(H,31,34,35)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384768
PNG
(US10285983, Compound 263)
Show SMILES O=C(Nc1cncc(c1)-c1cnc2[nH]nc(-c3cc4cccnc4[nH]3)c2c1)c1ccccc1
Show InChI InChI=1S/C25H17N7O/c33-25(15-5-2-1-3-6-15)29-19-9-17(12-26-14-19)18-10-20-22(31-32-24(20)28-13-18)21-11-16-7-4-8-27-23(16)30-21/h1-14H,(H,27,30)(H,29,33)(H,28,31,32)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384773
PNG
(US10285983, Compound 275)
Show SMILES O=C(Nc1cncc(c1)-c1cnc2[nH]nc(-c3cc4cccnc4[nH]3)c2c1)C1CCCCC1
Show InChI InChI=1S/C25H23N7O/c33-25(15-5-2-1-3-6-15)29-19-9-17(12-26-14-19)18-10-20-22(31-32-24(20)28-13-18)21-11-16-7-4-8-27-23(16)30-21/h4,7-15H,1-3,5-6H2,(H,27,30)(H,29,33)(H,28,31,32)
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n/an/an/an/a 1.26E+3n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384777
PNG
(US10285983, Compound 456)
Show SMILES CN(C)CCNc1cc(F)cc(c1)-c1ccnc2[nH]c(cc12)-c1n[nH]c2ncc(cc12)-c1cncc(NC(=O)C(C)(C)C)c1
Show InChI InChI=1S/C33H34FN9O/c1-33(2,3)32(44)39-24-12-20(16-35-18-24)21-13-27-29(41-42-31(27)38-17-21)28-15-26-25(6-7-37-30(26)40-28)19-10-22(34)14-23(11-19)36-8-9-43(4)5/h6-7,10-18,36H,8-9H2,1-5H3,(H,37,40)(H,39,44)(H,38,41,42)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384786
PNG
(US10285983, Compound 703)
Show SMILES C1CCC(CC1)Oc1cncc(c1)-c1cnc2[nH]nc(-c3cc4c(ccnc4[nH]3)-c3cccs3)c2c1
Show InChI InChI=1S/C28H24N6OS/c1-2-5-19(6-3-1)35-20-11-17(14-29-16-20)18-12-23-26(33-34-28(23)31-15-18)24-13-22-21(25-7-4-10-36-25)8-9-30-27(22)32-24/h4,7-16,19H,1-3,5-6H2,(H,30,32)(H,31,33,34)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384787
PNG
(US10285983, Compound 781)
Show SMILES CN(C)CCNc1cc(F)cc(c1)-c1ccnc2[nH]c(cc12)-c1n[nH]c2ncc(cc12)-c1cnc(C)n1C
Show InChI InChI=1S/C28H28FN9/c1-16-32-15-25(38(16)4)18-11-23-26(35-36-28(23)33-14-18)24-13-22-21(5-6-31-27(22)34-24)17-9-19(29)12-20(10-17)30-7-8-37(2)3/h5-6,9-15,30H,7-8H2,1-4H3,(H,31,34)(H,33,35,36)
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n/an/an/an/a 4.46E+3n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384728
PNG
(US10285983, Compound 36)
Show SMILES CC(C)(C)C(=O)Nc1cncc(c1)-c1cnc2[nH]nc(-c3cc4c(ccnc4[nH]3)-c3ccc(F)cc3)c2c1
Show InChI InChI=1S/C29H24FN7O/c1-29(2,3)28(38)34-20-10-17(13-31-15-20)18-11-23-25(36-37-27(23)33-14-18)24-12-22-21(8-9-32-26(22)35-24)16-4-6-19(30)7-5-16/h4-15H,1-3H3,(H,32,35)(H,34,38)(H,33,36,37)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384732
PNG
(US10285983, Compound 54)
Show SMILES Fc1ccc(cc1)-c1ccnc2[nH]c(cc12)-c1n[nH]c2ncc(cc12)-c1cncc(CN2CCC(F)(F)C2)c1
Show InChI InChI=1S/C29H22F3N7/c30-21-3-1-18(2-4-21)22-5-7-34-27-23(22)11-25(36-27)26-24-10-20(14-35-28(24)38-37-26)19-9-17(12-33-13-19)15-39-8-6-29(31,32)16-39/h1-5,7,9-14H,6,8,15-16H2,(H,34,36)(H,35,37,38)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384747
PNG
(US10285983, Compound 97)
Show SMILES CN(C)Cc1cncc(c1)-c1cnc2[nH]nc(-c3cc4c(ccnc4[nH]3)-c3cccnc3)c2c1
Show InChI InChI=1S/C26H22N8/c1-34(2)15-16-8-18(13-28-11-16)19-9-22-24(32-33-26(22)30-14-19)23-10-21-20(5-7-29-25(21)31-23)17-4-3-6-27-12-17/h3-14H,15H2,1-2H3,(H,29,31)(H,30,32,33)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384759
PNG
(US10285983, Compound 169)
Show SMILES CCC(=O)Nc1cncc(c1)-c1cnc2[nH]nc(-c3cc4c(ccnc4[nH]3)N3CCCCC3)c2c1
Show InChI InChI=1S/C26H26N8O/c1-2-23(35)30-18-10-16(13-27-15-18)17-11-20-24(32-33-26(20)29-14-17)21-12-19-22(6-7-28-25(19)31-21)34-8-4-3-5-9-34/h6-7,10-15H,2-5,8-9H2,1H3,(H,28,31)(H,30,35)(H,29,32,33)
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n/an/an/an/a 861n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384775
PNG
(US10285983, Compound 343)
Show SMILES CN(C)c1cncc(c1)-c1cnc2[nH]nc(-c3cc4c(ccnc4[nH]3)-c3cccs3)c2c1
Show InChI InChI=1S/C24H19N7S/c1-31(2)16-8-14(11-25-13-16)15-9-19-22(29-30-24(19)27-12-15)20-10-18-17(21-4-3-7-32-21)5-6-26-23(18)28-20/h3-13H,1-2H3,(H,26,28)(H,27,29,30)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384780
PNG
(US10285983, Compound 533)
Show SMILES Oc1cncc(c1)-c1cnc2[nH]nc(-c3cc4c(ccnc4[nH]3)-c3ccc(F)cc3)c2c1
Show InChI InChI=1S/C24H15FN6O/c25-16-3-1-13(2-4-16)18-5-6-27-23-19(18)9-21(29-23)22-20-8-15(11-28-24(20)31-30-22)14-7-17(32)12-26-10-14/h1-12,32H,(H,27,29)(H,28,30,31)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384722
PNG
(US10285983, Compound 18)
Show SMILES Fc1cccc(c1)-c1ccnc2[nH]c(cc12)-c1n[nH]c2ncc(cc12)-c1ccncc1
Show InChI InChI=1S/C24H15FN6/c25-17-3-1-2-15(10-17)18-6-9-27-23-19(18)12-21(29-23)22-20-11-16(13-28-24(20)31-30-22)14-4-7-26-8-5-14/h1-13H,(H,27,29)(H,28,30,31)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384724
PNG
(US10285983, Compound 24)
Show SMILES Fc1cccc(c1)-c1ccnc2[nH]c(cc12)-c1n[nH]c2ncc(cc12)-c1cncc(CNCc2ccccc2)c1
Show InChI InChI=1S/C32H24FN7/c33-25-8-4-7-22(12-25)26-9-10-36-31-27(26)14-29(38-31)30-28-13-24(19-37-32(28)40-39-30)23-11-21(17-35-18-23)16-34-15-20-5-2-1-3-6-20/h1-14,17-19,34H,15-16H2,(H,36,38)(H,37,39,40)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384731
PNG
(US10285983, Compound 51)
Show SMILES Fc1ccc(cc1)-c1ccnc2[nH]c(cc12)-c1n[nH]c2ncc(cc12)-c1cncc(NC(=O)C2CCCCC2)c1
Show InChI InChI=1S/C31H26FN7O/c32-22-8-6-18(7-9-22)24-10-11-34-29-25(24)14-27(37-29)28-26-13-21(16-35-30(26)39-38-28)20-12-23(17-33-15-20)36-31(40)19-4-2-1-3-5-19/h6-17,19H,1-5H2,(H,34,37)(H,36,40)(H,35,38,39)
UniProtKB/SwissProt

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n/an/an/an/a>1.00E+4n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384735
PNG
(US10285983, Compound 62)
Show SMILES CCNCc1cncc(c1)-c1cnc2[nH]nc(-c3cc4c(ccnc4[nH]3)-c3ccccc3F)c2c1
Show InChI InChI=1S/C27H22FN7/c1-2-29-12-16-9-17(14-30-13-16)18-10-22-25(34-35-27(22)32-15-18)24-11-21-19(7-8-31-26(21)33-24)20-5-3-4-6-23(20)28/h3-11,13-15,29H,2,12H2,1H3,(H,31,33)(H,32,34,35)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384739
PNG
(US10285983, Compound 72)
Show SMILES CC(C)(C)CC(=O)Nc1cncc(c1)-c1cnc2[nH]nc(-c3cc4c(ccnc4[nH]3)-c3ccccc3F)c2c1
Show InChI InChI=1S/C30H26FN7O/c1-30(2,3)13-26(39)35-19-10-17(14-32-16-19)18-11-23-27(37-38-29(23)34-15-18)25-12-22-20(8-9-33-28(22)36-25)21-6-4-5-7-24(21)31/h4-12,14-16H,13H2,1-3H3,(H,33,36)(H,35,39)(H,34,37,38)
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Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384745
PNG
(US10285983, Compound 93)
Show SMILES CC(C)C(=O)Nc1cncc(c1)-c1cnc2[nH]nc(-c3cc4c(ccnc4[nH]3)-c3cccnc3)c2c1
Show InChI InChI=1S/C27H22N8O/c1-15(2)27(36)32-19-8-17(12-29-14-19)18-9-22-24(34-35-26(22)31-13-18)23-10-21-20(5-7-30-25(21)33-23)16-4-3-6-28-11-16/h3-15H,1-2H3,(H,30,33)(H,32,36)(H,31,34,35)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384755
PNG
(US10285983, Compound 130)
Show SMILES c1c([nH]c2nccc(-c3ccncc3)c12)-c1n[nH]c2ncc(cc12)-c1ccncc1
Show InChI InChI=1S/C23H15N7/c1-6-24-7-2-14(1)16-11-19-21(29-30-23(19)27-13-16)20-12-18-17(5-10-26-22(18)28-20)15-3-8-25-9-4-15/h1-13H,(H,26,28)(H,27,29,30)
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Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384757
PNG
(US10285983, Compound 136)
Show SMILES C(NCc1cncc(c1)-c1cnc2[nH]nc(-c3cc4c(ccnc4[nH]3)-c3ccncc3)c2c1)c1ccccc1
Show InChI InChI=1S/C31H24N8/c1-2-4-20(5-3-1)15-33-16-21-12-23(18-34-17-21)24-13-27-29(38-39-31(27)36-19-24)28-14-26-25(8-11-35-30(26)37-28)22-6-9-32-10-7-22/h1-14,17-19,33H,15-16H2,(H,35,37)(H,36,38,39)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384764
PNG
(US10285983, Compound 188)
Show SMILES O=C(Nc1cncc(c1)-c1cnc2[nH]nc(-c3cc4c(ccnc4[nH]3)N3CCCCC3)c2c1)C1CC1
Show InChI InChI=1S/C27H26N8O/c36-27(16-4-5-16)31-19-10-17(13-28-15-19)18-11-21-24(33-34-26(21)30-14-18)22-12-20-23(6-7-29-25(20)32-22)35-8-2-1-3-9-35/h6-7,10-16H,1-5,8-9H2,(H,29,32)(H,31,36)(H,30,33,34)
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n/an/an/an/a 3.31E+3n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384781
PNG
(US10285983, Compound 563)
Show SMILES CN(C)CCOc1cncc(c1)-c1cnc2[nH]nc(-c3cc4c(ccnc4[nH]3)-c3cccnc3)c2c1
Show InChI InChI=1S/C27H24N8O/c1-35(2)8-9-36-20-10-18(14-29-16-20)19-11-23-25(33-34-27(23)31-15-19)24-12-22-21(5-7-30-26(22)32-24)17-4-3-6-28-13-17/h3-7,10-16H,8-9H2,1-2H3,(H,30,32)(H,31,33,34)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Istanbul University



Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

Bioorg Med Chem 16: 9113-20 (2008)


BindingDB Entry DOI: 10.7270/Q2D79DQJ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%