210 articles for thisTarget

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PMID	Data	Article Title	Organization
27770735	6	Analogue based drug design, synthesis, molecular docking and anticancer evaluation of novel chromene sulfonamide hybrids as aromatase inhibitors and apoptosis enhancers.	King Saud University
27979595	73	Imidazopyridyl compounds as aldosterone synthase inhibitors.	Merck Usa
27789139	69	Design, synthesis, and evaluation of (2S,4R)-Ketoconazole sulfonamide analogs as potential treatments for Metabolic Syndrome.	Temple University
27647367	36	A new Suzuki synthesis of triphenylethylenes that inhibit aromatase and bind to estrogen receptorsa andß.	Purdue University
27155469	8	Recent developments of C-4 substituted coumarin derivatives as anticancer agents.	Central University of Punjab
26689671	21	Recent Progress in the Discovery of Next Generation Inhibitors of Aromatase from the Structure-Function Perspective.	State University of New York Upstate Medical University
27161804	28	Synthesis and biological characterization of 3-(imidazol-1-ylmethyl)piperidine sulfonamides as aromatase inhibitors.	University of Chieti 'G. D'Annunzio
27160054	4	Exploring new chemical functionalities to improve aromatase inhibition of steroids.	University of Coimbra
27155563	5	Isocoumarins, miraculous natural products blessed with diverse pharmacological activities.	Quaid-I-Azam University
26938274	52	Exploiting the Chromone Scaffold for the Development of Inhibitors of Corticosteroid Biosynthesis.	University of Bologna
26469743	153	Developing steroidal aromatase inhibitors-an effective armament to win the battle against breast cancer.	The M. S. University of Baroda
26301554	49	Recent developments in steroidal and nonsteroidal aromatase inhibitors for the chemoprevention of estrogen-dependent breast cancer.	American University of Ras Al Khaimah
26288685	59	Discovery of Triazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys.	Merck Research Laboratories
25992880	90	Discovery and Development of the Aryl O-Sulfamate Pharmacophore for Oncology and Women's Health.	University of Bath
25934226	24	Synthesis and molecular docking of 1,2,3-triazole-based sulfonamides as aromatase inhibitors.	Srinakharinwirot University
26005536	92	Discovery of Benzimidazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys.	Merck Research Laboratories
25874338	90	Identification of 4-(4-nitro-2-phenethoxyphenyl)pyridine as a promising new lead for discovering inhibitors of both human and rat 11ß-Hydroxylase.	Saarland University
25751283	79	Design and synthesis of norendoxifen analogues with dual aromatase inhibitory and estrogen receptor modulatory activities.	Purdue University
25711516	118	Novel pyridyl substituted 4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolines as potent and selective aldosterone synthase inhibitors with improved in vitro metabolic stability.	Saarland University and Helmholtz Institute For Pharmaceutical Research Saarland (Hips)
25277066	10	Exemestane metabolites: Synthesis, stereochemical elucidation, biochemical activity and anti-proliferative effects in a hormone-dependent breast cancer cell line.	University of Coimbra
25528333	32	Heteroatom insertion into 3,4-dihydro-1H-quinolin-2-ones leads to potent and selective inhibitors of human and rat aldosterone synthase.	Saarland University
25461329	9	Bioactive benzofuran derivatives: moracins A-Z in medicinal chemistry.	Dongguk University-Seoul
24992702	2	Spongiapyridine and related spongians isolated from an Indonesian Spongia sp.	University of Hawaii At Manoa
24422519	31	Aldosterone synthase inhibitors as promising treatments for mineralocorticoid dependent cardiovascular and renal diseases.	Saarland University and Helmholtz Institute For Pharmaceutical Research Saarland (Hips)
25462231	85	Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4'-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11ß-hydroxylase.	Universit£
25155384	16	Discovery of a new class of cinnamyl-triazole as potent and selective inhibitors of aromatase (cytochrome P450 19A1).	Mcmaster University
722711	5	Synthesis and biochemical evaluation of inhibitors of estrogen biosynthesis.	TBA
24630560	2	Inhibitory effect of Rhus verniciflua Stokes extract on human aromatase activity; butin is its major bioactive component.	Hanyang University
24345481	14	Investigation of fluorinated and bifunctionalized 3-phenylchroman-4-one (isoflavanone) aromatase inhibitors.	Northern Kentucky University
24331756	9	Pyrrolizines: Promising scaffolds for anticancer drugs.	Beni-Suef University
24900631	50	Discovery and in Vivo Evaluation of Potent Dual CYP11B2 (Aldosterone Synthase) and CYP11B1 Inhibitors.	Novartis Institutes For Biomedical Research
24113062	17	Investigation of aryl halides as ketone bioisosteres: refinement of potent and selective inhibitors of human cytochrome P450 19A1 (aromatase).	Mcmaster University
24025069	36	Design, synthesis, and structure-activity relationships of azolylmethylpyrroloquinolines as nonsteroidal aromatase inhibitors.	University of Padova
24074257	6	Synthesis and bioconversions of formestane.	The University of Tampa
23994869	6	Chemopreventive and antioxidant activity of 6-substituted imidazo[2,1-b]thiazoles.	Universit£
23859149	76	Highly potent and selective nonsteroidal dual inhibitors of CYP17/CYP11B2 for the treatment of prostate cancer to reduce risks of cardiovascular diseases.	Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland (Hips)
23731360	12	Synthesis of mixed (E,Z)-, (E)-, and (Z)-norendoxifen with dual aromatase inhibitory and estrogen receptor modulatory activities.	Purdue University
23403081	20	Design, synthesis and aromatase inhibitory activities of novel indole-imidazole derivatives.	Key Laboratory of Medicinal Chemistry For Natural Resource (Yunnan University)
23363058	68	Modulation of cytochromes P450 with xanthone-based molecules: from aromatase to aldosterone synthase and steroid 11ß-hydroxylase inhibition.	University of Bologna
23281812	95	Tetrahydropyrroloquinolinone type dual inhibitors of aromatase/aldosterone synthase as a novel strategy for breast cancer patients with elevated cardiovascular risks.	Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland (Hips)
3361583	5	Analogues of aminoglutethimide based on 1-phenyl-3-azabicyclo[3.1.0]hexane-2,4-dione: selective inhibition of aromatase activity.	Institute of Cancer Research
3959033	7	Synthesis and evaluation of 4-(substituted thio)-4-androstene-3,17-dione derivatives as potential aromatase inhibitors.	TBA
3968684	2	Analogues of aminoglutethimide: selective inhibition of aromatase.	TBA
23142320	14	Optimization of thiazole analogues of resveratrol for induction of NAD(P)H:quinone reductase 1 (QR1).	Purdue University
22951074	11	Novel aromatase inhibitors by structure-guided design.	State University of New York Upstate Medical University
22861193	60	Selective dual inhibitors of CYP19 and CYP11B2: targeting cardiovascular diseases hiding in the shadow of breast cancer.	Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland (Hips)
22788843	46	Novel imidazol-1-ylmethyl substituted 1,2,5,6-tetrahydropyrrolo[3,2,1-ij]quinolin-4-ones as potent and selective CYP11B1 inhibitors for the treatment of Cushing's syndrome.	Saarland University and Helmholtz Institute For Pharmaceutical Research Saarland (Hips)
22475216	13	New structure-activity relationships of A- and D-ring modified steroidal aromatase inhibitors: design, synthesis, and biochemical evaluation.	University of Coimbra
22444875	25	Development of a new class of aromatase inhibitors: design, synthesis and inhibitory activity of 3-phenylchroman-4-one (isoflavanone) derivatives.	Northern Kentucky University
21174408	13	Radical scavenging and antioxidant activities of isocoumarins and a phthalide from the endophytic fungus Colletotrichum sp.	Chulabhorn Institute
20550118	69	Isopropylidene substitution increases activity and selectivity of biphenylmethylene 4-pyridine type CYP17 inhibitors.	Saarland University
20558073	28	Design, synthesis, and biological evaluation of resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer.	Purdue University
20568782	16	Novel highly potent and selective nonsteroidal aromatase inhibitors: synthesis, biological evaluation and structure-activity relationships investigation.	University of Bologna
20413308	53	Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19).	Johns Hopkins University
20148564	60	Highly potent first examples of dual aromatase-steroid sulfatase inhibitors based on a biphenyl template.	University of Bath
18778944	8	Screening of herbal constituents for aromatase inhibitory activity.	King'S College London
18462007	7	Selective inhibition of aromatase by a dihydroisocoumarin from Xyris pterygoblephara.	Universidade Federal De Minas Gerais
18357974	42	"Virtual fragment linking": an approach to identify potent binders from low affinity fragment hits.	Novartis Institutes For Biomedical Research
18042388	13	New 7,8-benzoflavanones as potent aromatase inhibitors: synthesis and biological evaluation.	Upres Ea 4021 Biomol�Cules Et Th�Rapies Anti-Tumorales
18271519	65	Novel sulfonanilide analogs decrease aromatase activity in breast cancer cells: synthesis, biological evaluation, and ligand-based pharmacophore identification.	The Ohio State University
17511439	24	Synthesis and biological evaluation of (+/-)-abyssinone II and its analogues as aromatase inhibitors for chemoprevention of breast cancer.	Purdue University
16190763	9	Structure-activity relationships of new A,D-ring modified steroids as aromatase inhibitors: design, synthesis, and biological activity evaluation.	University of Oporto
12930139	22	Fluorine substitution can block CYP3A4 metabolism-dependent inhibition: identification of (S)-N-[1-(4-fluoro-3- morpholin-4-ylphenyl)ethyl]-3- (4-fluorophenyl)acrylamide as an orally bioavailable KCNQ2 opener devoid of CYP3A4 metabolism-dependent inhibition.	Bristol-Myers Squibb Pharmaceutical Research Institute
1578485	19	Synthesis and evaluation of a new series of mechanism-based aromatase inhibitors.	Centre De Recherches Roussel-Uclaf
1875347	23	Synthesis and biochemical studies of 16- or 19-substituted androst-4-enes as aromatase inhibitors.	Tohoku College of Pharmacy
1825337	22	Fadrozole hydrochloride: a potent, selective, nonsteroidal inhibitor of aromatase for the treatment of estrogen-dependent disease.	Ciba-Geigy
2231592	36	Mechanism and inhibition of cytochrome P-450 aromatase.	Johns Hopkins University School of Medicine
2918514	17	Effects of steroid D-ring modification on suicide inactivation and competitive inhibition of aromatase by analogues of androsta-1,4-diene-3,17-dione.	Washington University
2677377	3	Is there a case for P-450 inhibitors in cancer treatment?	Janssen Research Foundation
2909733	6	Interactions of thiol-containing androgens with human placental aromatase.	University of Washington
6827528	1	Analogues of aminoglutethimide: selective inhibition of cholesterol side-chain cleavage.	TBA
22386564	43	Optimization of the aromatase inhibitory activities of pyridylthiazole analogues of resveratrol.	Purdue University
22335894	10	New aromatase inhibitors from the 3-pyridyl arylether and 1-aryl pyrrolo[2,3-c]pyridine series.	Novartis Institutes For Biomedical Research
22115839	42	Optimizing thiadiazole analogues of resveratrol versus three chemopreventive targets.	Purdue University
22079757	13	Discovery of a novel class of aldol-derived 1,2,3-triazoles: potent and selective inhibitors of human cytochrome P450 19A1 (aromatase).	Mcmaster University
21978950	28	Design, synthesis, and biological evaluation of callophycin A and analogues as potential chemopreventive and anticancer agents.	University of Hawaii At Hilo
21937153	46	Recent progress in synthesis and bioactivity studies of indolizines.	University of Botswana
21703734	68	Synthesis and structure-activity relationship of 1- and 2-substituted-1,2,3-triazole letrozole-based analogues as aromatase inhibitors.	Universit£
21604760	31	Structure-based design of potent aromatase inhibitors by high-throughput docking.	Universita` Di Modena E Reggio Emilia
21497425	13	Lead optimization of 4-imidazolylflavans: new promising aromatase inhibitors.	Upres Ea 4021 Biomol�Cules Et Th�Rapies Anti-Tumorales
21384875	67	Fine-tuning the selectivity of aldosterone synthase inhibitors: structure-activity and structure-selectivity insights from studies of heteroaryl substituted 1,2,5,6-tetrahydropyrrolo[3,2,1-ij]quinolin-4-one derivatives.	Saarland University
21341743	42	Design, synthesis, and biological evaluation of imidazolyl derivatives of 4,7-disubstituted coumarins as aromatase inhibitors selective over 17-a-hydroxylase/C17-20 lyase.	Universita` Degli Studi Di Bari Aldo Moro
21261296	6	Bioactive compounds from the fern Lepisorus contortus.	Yunnan Normal University
24900302	27	Hybrid Dual Aromatase-Steroid Sulfatase Inhibitors with Exquisite Picomolar Inhibitory Activity	TBA
21129965	18	N-(Pyridin-3-yl)benzamides as selective inhibitors of human aldosterone synthase (CYP11B2).	Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland
20926163	32	Molecular docking and QSAR study on steroidal compounds as aromatase inhibitors.	Tianjin University of Science and Technology
20638757	89	Exploring benzcyclo derivatives as potent aromatase inhibitors using ligand-based modeling studies.	University of Calcutta
20684610	73	Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prostate cancer.	Saarland University
19824618	1	Aspergillusol A, an alpha-glucosidase inhibitor from the marine-derived fungus Aspergillus aculeatus.	Institute and The Center For Environmental Health
19500885	10	An efficient steroid pharmacophore-based strategy to identify new aromatase inhibitors.	Universidade De Coimbra
18939864	3	Monodictyochromes A and B, Dimeric Xanthone Derivatives from the Marine Algicolous Fungus Monodictys putredinis.	University of Bonn
19608417	26	Synthesis and biochemical evaluation of a range of sulfonated derivatives of 4-hydroxybenzyl imidazole as highly potent inhibitors of rat testicular 17alpha-hydroxylase/17,20-lyase (P-450(17alpha)).	University of The West of Scotland
	8	The synthesis of N-aryl androsterone pyrazoles as aromatase inhibitors	TBA
	4	Synthesis of 7α-substituted androstenediones by a 1,4-conjugate addition approach	TBA
	1	Molecular modelling of inhibitors of aromatase — a novel approach	TBA
19072235	98	Fast three dimensional pharmacophore virtual screening of new potent non-steroid aromatase inhibitors.	Universidade De Coimbra
19049427	98	In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-1H-quinolin-2-one derivatives.	Saarland University
18782670	39	CYP19 (aromatase): exploring the scaffold flexibility for novel selective inhibitors.	Università
18763754	57	Novel aldosterone synthase inhibitors with extended carbocyclic skeleton by a combined ligand-based and structure-based drug design approach.	Saarland University
18672861	91	Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization on potency and selectivity.	Saarland University
18640836	9	Synthesis of 6- or 4-functionalized indoles via a reductive cyclization approach and evaluation as aromatase inhibitors.	Université
18558747	5	Xanthones from the botanical dietary supplement mangosteen (Garcinia mangostana) with aromatase inhibitory activity.	University of Illinois At Chicago
18192087	9	Evaluation of ursolic acid isolated from Ilex paraguariensis and derivatives on aromatase inhibition.	Universidade Federal Do Rio Grande Do Sul (Ufrgs)
16643058	7	Interference by naturally occurring fatty acids in a noncellular enzyme-based aromatase bioassay.	University of Illinois At Chicago
11678652	16	Aromatase inhibitors from Broussonetia papyrifera.	University of Illinois At Chicago
17585752	10	Imidazolylmethylbenzophenones as highly potent aromatase inhibitors.	TBA
17315855	7	Synthesis and biological evaluation of selective aromatase expression regulators in breast cancer cells.	The Ohio State University
17291041	7	Potential cancer chemopreventive in vitro activities of monomeric xanthone derivatives from the marine algicolous fungus Monodictys putredinis.	University of Bonn
16854084	19	Lead optimization providing a series of flavone derivatives as potent nonsteroidal inhibitors of the cytochrome P450 aromatase enzyme.	University of Bologna
16480277	18	Novel sulfonanilide analogues suppress aromatase expression and activity in breast cancer cells independent of COX-2 inhibition.	The Ohio State University
16380254	9	Synthesis and biological evaluation of 5-[(aryl)(1H-imidazol-1-yl)methyl]-1H-indoles: potent and selective aromatase inhibitors.	Nantes University
15380230	5	Synthesis and evaluation of 4-triazolylflavans as new aromatase inhibitors.	Upres Ea 1085 BiomoléCules Et Cibles Cellulaires Tumorales
14584934	15	Identification of a potent and selective 5-HT(6) antagonist: one-step synthesis of (E)-3-(benzenesulfonyl)-2- (methylsulfanyl)pyrido[1,2-a]pyrimidin-4-ylidenamine from 2-(benzenesulfonyl)-3,3-bis(methylsulfanyl)acrylonitrile.	Bristol-Myers Squibb Pharmaceutical Research Institute
12699753	12	Preparation and pharmacological profile of 7-(alpha-azolylbenzyl)-1H-indoles and indolines as new aromatase inhibitors.	Ufr Des Sciences Pharmaceutiques
12270163	5	Design, synthesis and evaluation of 4-imidazolylflavans as new leads for aromatase inhibition.	Upres Ea 1085
11909717	7	New aromatase inhibitors. Synthesis and inhibitory activity of pyridinyl-substituted flavanone derivatives.	Upres Ea 1085
11262078	19	A new class of nonsteroidal aromatase inhibitors: design and synthesis of chromone and xanthone derivatives and inhibition of the P450 enzymes aromatase and 17 alpha-hydroxylase/C17,20-lyase.	University of Bologna
32435378	4	Targeting Orthosteric and Allosteric Pockets of Aromatase via Dual-Mode Novel Azole Inhibitors.	Alma Mater Studiorum-University of Bologna
11087568	55	Synthesis and evaluation of 17-aliphatic heterocycle-substituted steroidal inhibitors of 17alpha-hydroxylase/C17-20-lyase (P450 17).	University of The Saarland
27567077	28	Synthesis and aromatase inhibitory evaluation of 4-N-nitrophenyl substituted amino-4H-1,2,4-triazole derivatives.	Key Laboratory of Industrial Fermentation Microbiology (Tianjin University of Science & Technology)
32302132	74	Design and Characterization of the First Selective and Potent Mechanism-Based Inhibitor of Cytochrome P450 4Z1.	University of Washington
31255926	46	Sulfamates in drug design and discovery: Pre-clinical and clinical investigations.	University of Sharjah
31129450	72	Estrogen signaling: An emanating therapeutic target for breast cancer treatment.	Indian Institute of Technology (Bhu)
10450990	8	1-[(Benzofuran-2-yl)phenylmethyl]-triazoles and -tetrazoles - potent competitive inhibitors of aromatase.	Cardiff University
30852901	16	C-6?- vs C-7?-Substituted Steroidal Aromatase Inhibitors: Which Is Better? Synthesis, Biochemical Evaluation, Docking Studies, and Structure-Activity Relationships.	University of Coimbra
30822713	7	Rational design of allosteric modulators of the aromatase enzyme: An unprecedented therapeutic strategy to fight breast cancer.	Cnr-Iom-Democritos C/O International School For Advanced Studies (Sissa)
10091679	9	New selective nonsteroidal aromatase inhibitors: synthesis and inhibitory activity of 2,3 or 5-(alpha-azolylbenzyl)-1H-indoles.	Nantes
31416738	38	Synthesis, molecular docking, and QSAR study of bis-sulfonamide derivatives as potential aromatase inhibitors.	Srinakharinwirot University
9871704	8	Design and synthesis of a new type of non steroidal human aromatase inhibitors.	Centre D'Etudes Et De Recherche Sur Le MéDicament De Normandie
31536895	27	Indole: A privileged scaffold for the design of anti-cancer agents.	Hunan University of Science and Technology
30952594	13	Synthesis of ?-methylstilbenes using an aqueous Wittig methodology and application toward the development of potent human aromatase inhibitors.	Mcmaster University
9379446	10	6 beta-Propynyl-substituted steroids: mechanism-based enzyme-activated irreversible inhibitors of aromatase.	University of Minnesota
9357513	15	6-Chloro-5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]- indoline (SB-242084): the first selective and brain penetrant 5-HT2C receptor antagonist.	Smithkline Beecham Pharmaceuticals
31732252	5	Synthesis, biological evaluation, and docking study of indole aryl sulfonamides as aromatase inhibitors.	"G. D'Annunzio" University
8765515	37	3- and 4-pyridylalkyl adamantanecarboxylates: inhibitors of human cytochrome P450(17 alpha) (17 alpha-hydroxylase/C17,20-lyase). Potential nonsteroidal agents for the treatment of prostatic cancer.	Cancer Research Campaign Centre For Cancer Therapeutics
31312408	49	Development of Highly Selective Pyrimidine-Based Aldosterone Synthase (CYP11B2) Inhibitors.	Selenity Therapeutics
8632407	43	Tetrahydronaphthalenes: influence of heterocyclic substituents on inhibition of steroid enzymes P450 arom and P450 17.	UniversitäT De Saarlandes
26540564	30	Discovery of N-[5-(6-Chloro-3-cyano-1-methyl-1H-indol-2-yl)-pyridin-3-ylmethyl]-ethanesulfonamide, a Cortisol-Sparing CYP11B2 Inhibitor that Lowers Aldosterone in Human Subjects.	Novartis Institutes For Biomedical Research
8496907	8	Aromatase inhibitors: synthesis, biological activity, and binding mode of azole-type compounds.	Ciba-Geigy
8340925	18	Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering.	Syntex Discovery Research
8176709	32	6-Alkyl- and 6-arylandrost-4-ene-3,17-diones as aromatase inhibitors. Synthesis and structure-activity relationships.	Tohoku College of Pharmacy
8176705	25	Aromatase inhibitors. Syntheses and structure-activity studies of novel pyridyl-substituted indanones, indans, and tetralins.	UniversitäT Des Saarlandes
8035427	51	Synthesis of androst-5-en-7-ones and androsta-3,5-dien-7-ones and their related 7-deoxy analogs as conformational and catalytic probes for the active site of aromatase.	Tohoku College of Pharmacy
7783141	28	Pyridyl-substituted tetrahydrocyclopropa[a]naphthalenes: highly active and selective inhibitors of P450 arom.	UniversitäT Des Saarlandes
7636845	8	Synthesis, structure elucidation, and biochemical evaluation of 7 alpha- and 7 beta-arylaliphatic-substituted androst-4-ene-3,17-diones as inhibitors of aromatase.	Ohio State University
7608911	35	Novel steroidal inhibitors of human cytochrome P45017 alpha (17 alpha-hydroxylase-C17,20-lyase): potential agents for the treatment of prostatic cancer.	Institute of Cancer Research
7562951	4	Probing the hydrophobic pocket of the active site of aromatase with 4-phenoxy-7 alpha-(phenylthio)-4-androstene-3,17-dione.	University of Minnesota
7473546	61	Esters of 3-pyridylacetic acid that combine potent inhibition of 17 alpha-hydroxylase/C17,20-lyase (cytochrome P45017 alpha) with resistance to esterase hydrolysis.	Crc Laboratory
3754286	17	Synthesis and biochemical evaluation of analogues of aminoglutethimide based on phenylpyrrolidine-2,5-dione.	TBA
3735304	14	Aromatase inhibitors. Synthesis and evaluation of mammary tumor inhibiting activity of 3-alkylated 3-(4-aminophenyl)piperidine-2,6-diones.	TBA
3625703	38	Analogues of 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione as selective inhibitors of aromatase: derivatives with variable 1-alkyl and 3-alkyl substituents.	TBA
29525337	27	Studies on non-steroidal inhibitors of aromatase enzyme; 4-(aryl/heteroaryl)-2-(pyrimidin-2-yl)thiazole derivatives.	Istanbul Medipol University
29254646	17	Dihydrobenzisoxazole-4-one compounds are novel selective inhibitors of aldosterone synthase (CYP11B2) with in vivo activity.	Boehringer Ingelheim Pharmaceuticals
29153737	10	Structure-activity relationships and docking studies of synthetic 2-arylindole derivatives determined with aromatase and quinone reductase 1.	University of Hawai'I At Hilo
28319389	31	Potential Antiosteoporotic Natural Product Lead Compounds That Inhibit 17?-Hydroxysteroid Dehydrogenase Type 2.	University of Basel
29202405	21	Potent aromatase inhibitors and molecular mechanism of inhibitory action.	Yunnan University
29137864	36	Synthesis, molecular docking, and QSAR study of sulfonamide-based indoles as aromatase inhibitors.	Srinakharinwirot University
2391706	22	Crystallographic and molecular modeling studies on 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione and its butyl analogue, inhibitors of mammalian aromatase. Comparison with natural substrates: prediction of enantioselectivity for N-alkyl derivatives.	Institute of Cancer Research
2296006	7	Synthesis and biochemical studies of 7-substituted 4,6-androstadiene-3,17-diones as aromatase inhibitors.	Ohio State University
2231604	69	Inhibition of enzymes of estrogen and androgen biosynthesis by esters of 4-pyridylacetic acid.	Institute of Cancer Research
29803730	42	Design and synthesis of functionalized piperazin-1yl-(E)-stilbenes as inhibitors of 17?-hydroxylase-C17,20-lyase (Cyp17).	Temple University
28651982	47	Design and optimization of highly-selective, broad spectrum fungal CYP51 inhibitors.	Viamet Pharmaceuticals
2033599	8	Novel time-dependent inhibitors of human placental aromatase.	Marion Merrell Dow Research Institute
2016709	8	Inhibition of human placental aromatase by novel homologated 19-oxiranyl and 19-thiiranyl steroids.	Johns Hopkins University School of Medicine
2016706	29	Synthesis and aromatase inhibitory activity of novel 1-(4-aminophenyl)-3-azabicyclo[3.1.0]hexane- and -[3.1.1]heptane-2,4- diones.	Ciba-Geigy
1895288	23	New aromatase inhibitors. Synthesis and biological activity of pyridyl-substituted tetralone derivatives.	UniversitäT Des Saarlandes
28427017	5	Aromatase inhibitors and apoptotic inducers: Design, synthesis, anticancer activity and molecular modeling studies of novel phenothiazine derivatives carrying sulfonamide moiety as hybrid molecules.	King Saud University
1613747	10	Synthesis and aromatase inhibition of 3-cycloalkyl-substituted 3-(4-aminophenyl)piperidine-2,6-diones.	UniversitäT Des Saarlandes
28416132	96	Discovery of indazole aldosterone synthase (CYP11B2) inhibitors as potential treatments for hypertension.	Merck Research Laboratories
1495014	36	Stereoisomers of ketoconazole: preparation and biological activity.	Syntex Research
28512028	20	Evaluation of synthesized coumarin derivatives on aromatase inhibitory activity.	Health Sciences University of Hokkaido
1433182	11	Conformational analysis of the aromatase inhibitor 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione (rogletimide) and discovery of potent 5-alkyl derivatives.	Institute of Cancer Research
27439119	16	Structure-Based Screening of Uncharted Chemical Space for Atypical Adenosine Receptor Agonists	Uppsala University
25581511	32	The Synthesis and Evaluation of C7-Substituted a-Tetralone Derivatives as Inhibitors of Monoamine Oxidase.	North-West University
8824284	43	Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior.	Bayer
2137193	4	Molecular cloning and expression of a dopamine D2 receptor from human retina.	National Institute of Neurological Disorders and Stroke
18096504	19	URB602 inhibits monoacylglycerol lipase and selectively blocks 2-arachidonoylglycerol degradation in intact brain slices.	University of California Irvine
18022559	4	Inverse in silico screening for identification of kinase inhibitor targets.	University of Munich
10980448	3	Human liver glycogen phosphorylase inhibitors bind at a new allosteric site.	Pfizer
18849972	45	Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase.	The Scripps Research Institute
18249537	56	Development of pyridopyrimidines as potent Akt1/2 inhibitors.	Merck Research Laboratories
16420054	24	Structure-activity study of brassinin derivatives as indoleamine 2,3-dioxygenase inhibitors.	Bryn Mawr College
18318466	41	Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors.	Bryn Mawr College
16951187	11	AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts.	Amgen
18763753	29	Design, synthesis, and biological evaluation of potent c-Met inhibitors.	Amgen
18637666	7	Novel 4-aminoquinolines active against chloroquine-resistant and sensitive P. falciparum strains that also inhibit botulinum serotype A.	University of Belgrade
18630890	24	A pentacyclic aurora kinase inhibitor (AKI-001) with high in vivo potency and oral bioavailability.	Genentech
18665584	32	Structure based development of phenylimidazole-derived inhibitors of indoleamine 2,3-dioxygenase.	Bryn Mawr College
18656911	39	Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a novel cyclin dependent kinase inhibitor using fragment-based X-ray crystallography and structure based drug design.	Astex
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