The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
27770735 |
6 |
Analogue based drug design, synthesis, molecular docking and anticancer evaluation of novel chromene sulfonamide hybrids as aromatase inhibitors and apoptosis enhancers. |
King Saud University |
27979595 |
73 |
Imidazopyridyl compounds as aldosterone synthase inhibitors. |
Merck Usa |
27789139 |
69 |
Design, synthesis, and evaluation of (2S,4R)-Ketoconazole sulfonamide analogs as potential treatments for Metabolic Syndrome. |
Temple University |
27647367 |
36 |
A new Suzuki synthesis of triphenylethylenes that inhibit aromatase and bind to estrogen receptorsa andß. |
Purdue University |
27155469 |
8 |
Recent developments of C-4 substituted coumarin derivatives as anticancer agents. |
Central University of Punjab |
26689671 |
21 |
Recent Progress in the Discovery of Next Generation Inhibitors of Aromatase from the Structure-Function Perspective. |
State University of New York Upstate Medical University |
27161804 |
28 |
Synthesis and biological characterization of 3-(imidazol-1-ylmethyl)piperidine sulfonamides as aromatase inhibitors. |
University of Chieti 'G. D'Annunzio |
27160054 |
4 |
Exploring new chemical functionalities to improve aromatase inhibition of steroids. |
University of Coimbra |
27155563 |
5 |
Isocoumarins, miraculous natural products blessed with diverse pharmacological activities. |
Quaid-I-Azam University |
26938274 |
52 |
Exploiting the Chromone Scaffold for the Development of Inhibitors of Corticosteroid Biosynthesis. |
University of Bologna |
26469743 |
153 |
Developing steroidal aromatase inhibitors-an effective armament to win the battle against breast cancer. |
The M. S. University of Baroda |
26301554 |
49 |
Recent developments in steroidal and nonsteroidal aromatase inhibitors for the chemoprevention of estrogen-dependent breast cancer. |
American University of Ras Al Khaimah |
26288685 |
59 |
Discovery of Triazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys. |
Merck Research Laboratories |
25992880 |
90 |
Discovery and Development of the Aryl O-Sulfamate Pharmacophore for Oncology and Women's Health. |
University of Bath |
25934226 |
24 |
Synthesis and molecular docking of 1,2,3-triazole-based sulfonamides as aromatase inhibitors. |
Srinakharinwirot University |
26005536 |
92 |
Discovery of Benzimidazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys. |
Merck Research Laboratories |
25874338 |
90 |
Identification of 4-(4-nitro-2-phenethoxyphenyl)pyridine as a promising new lead for discovering inhibitors of both human and rat 11ß-Hydroxylase. |
Saarland University |
25751283 |
79 |
Design and synthesis of norendoxifen analogues with dual aromatase inhibitory and estrogen receptor modulatory activities. |
Purdue University |
25711516 |
118 |
Novel pyridyl substituted 4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolines as potent and selective aldosterone synthase inhibitors with improved in vitro metabolic stability. |
Saarland University and Helmholtz Institute For Pharmaceutical Research Saarland (Hips) |
25277066 |
10 |
Exemestane metabolites: Synthesis, stereochemical elucidation, biochemical activity and anti-proliferative effects in a hormone-dependent breast cancer cell line. |
University of Coimbra |
25528333 |
32 |
Heteroatom insertion into 3,4-dihydro-1H-quinolin-2-ones leads to potent and selective inhibitors of human and rat aldosterone synthase. |
Saarland University |
25461329 |
9 |
Bioactive benzofuran derivatives: moracins A-Z in medicinal chemistry. |
Dongguk University-Seoul |
24992702 |
2 |
Spongiapyridine and related spongians isolated from an Indonesian Spongia sp. |
University of Hawaii At Manoa |
24422519 |
31 |
Aldosterone synthase inhibitors as promising treatments for mineralocorticoid dependent cardiovascular and renal diseases. |
Saarland University and Helmholtz Institute For Pharmaceutical Research Saarland (Hips) |
25462231 |
85 |
Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4'-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11ß-hydroxylase. |
Universit£ |
25155384 |
16 |
Discovery of a new class of cinnamyl-triazole as potent and selective inhibitors of aromatase (cytochrome P450 19A1). |
Mcmaster University |
722711 |
5 |
Synthesis and biochemical evaluation of inhibitors of estrogen biosynthesis. |
TBA |
24630560 |
2 |
Inhibitory effect of Rhus verniciflua Stokes extract on human aromatase activity; butin is its major bioactive component. |
Hanyang University |
24345481 |
14 |
Investigation of fluorinated and bifunctionalized 3-phenylchroman-4-one (isoflavanone) aromatase inhibitors. |
Northern Kentucky University |
24331756 |
9 |
Pyrrolizines: Promising scaffolds for anticancer drugs. |
Beni-Suef University |
24900631 |
50 |
Discovery and in Vivo Evaluation of Potent Dual CYP11B2 (Aldosterone Synthase) and CYP11B1 Inhibitors. |
Novartis Institutes For Biomedical Research |
24113062 |
17 |
Investigation of aryl halides as ketone bioisosteres: refinement of potent and selective inhibitors of human cytochrome P450 19A1 (aromatase). |
Mcmaster University |
24025069 |
36 |
Design, synthesis, and structure-activity relationships of azolylmethylpyrroloquinolines as nonsteroidal aromatase inhibitors. |
University of Padova |
24074257 |
6 |
Synthesis and bioconversions of formestane. |
The University of Tampa |
23994869 |
6 |
Chemopreventive and antioxidant activity of 6-substituted imidazo[2,1-b]thiazoles. |
Universit£ |
23859149 |
76 |
Highly potent and selective nonsteroidal dual inhibitors of CYP17/CYP11B2 for the treatment of prostate cancer to reduce risks of cardiovascular diseases. |
Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland (Hips) |
23731360 |
12 |
Synthesis of mixed (E,Z)-, (E)-, and (Z)-norendoxifen with dual aromatase inhibitory and estrogen receptor modulatory activities. |
Purdue University |
23403081 |
20 |
Design, synthesis and aromatase inhibitory activities of novel indole-imidazole derivatives. |
Key Laboratory of Medicinal Chemistry For Natural Resource (Yunnan University) |
23363058 |
68 |
Modulation of cytochromes P450 with xanthone-based molecules: from aromatase to aldosterone synthase and steroid 11ß-hydroxylase inhibition. |
University of Bologna |
23281812 |
95 |
Tetrahydropyrroloquinolinone type dual inhibitors of aromatase/aldosterone synthase as a novel strategy for breast cancer patients with elevated cardiovascular risks. |
Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland (Hips) |
3361583 |
5 |
Analogues of aminoglutethimide based on 1-phenyl-3-azabicyclo[3.1.0]hexane-2,4-dione: selective inhibition of aromatase activity. |
Institute of Cancer Research |
3959033 |
7 |
Synthesis and evaluation of 4-(substituted thio)-4-androstene-3,17-dione derivatives as potential aromatase inhibitors. |
TBA |
3968684 |
2 |
Analogues of aminoglutethimide: selective inhibition of aromatase. |
TBA |
23142320 |
14 |
Optimization of thiazole analogues of resveratrol for induction of NAD(P)H:quinone reductase 1 (QR1). |
Purdue University |
22951074 |
11 |
Novel aromatase inhibitors by structure-guided design. |
State University of New York Upstate Medical University |
22861193 |
60 |
Selective dual inhibitors of CYP19 and CYP11B2: targeting cardiovascular diseases hiding in the shadow of breast cancer. |
Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland (Hips) |
22788843 |
46 |
Novel imidazol-1-ylmethyl substituted 1,2,5,6-tetrahydropyrrolo[3,2,1-ij]quinolin-4-ones as potent and selective CYP11B1 inhibitors for the treatment of Cushing's syndrome. |
Saarland University and Helmholtz Institute For Pharmaceutical Research Saarland (Hips) |
22475216 |
13 |
New structure-activity relationships of A- and D-ring modified steroidal aromatase inhibitors: design, synthesis, and biochemical evaluation. |
University of Coimbra |
22444875 |
25 |
Development of a new class of aromatase inhibitors: design, synthesis and inhibitory activity of 3-phenylchroman-4-one (isoflavanone) derivatives. |
Northern Kentucky University |
21174408 |
13 |
Radical scavenging and antioxidant activities of isocoumarins and a phthalide from the endophytic fungus Colletotrichum sp. |
Chulabhorn Institute |
20550118 |
69 |
Isopropylidene substitution increases activity and selectivity of biphenylmethylene 4-pyridine type CYP17 inhibitors. |
Saarland University |
20558073 |
28 |
Design, synthesis, and biological evaluation of resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer. |
Purdue University |
20568782 |
16 |
Novel highly potent and selective nonsteroidal aromatase inhibitors: synthesis, biological evaluation and structure-activity relationships investigation. |
University of Bologna |
20413308 |
53 |
Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19). |
Johns Hopkins University |
20148564 |
60 |
Highly potent first examples of dual aromatase-steroid sulfatase inhibitors based on a biphenyl template. |
University of Bath |
18778944 |
8 |
Screening of herbal constituents for aromatase inhibitory activity. |
King'S College London |
18462007 |
7 |
Selective inhibition of aromatase by a dihydroisocoumarin from Xyris pterygoblephara. |
Universidade Federal De Minas Gerais |
18357974 |
42 |
"Virtual fragment linking": an approach to identify potent binders from low affinity fragment hits. |
Novartis Institutes For Biomedical Research |
18042388 |
13 |
New 7,8-benzoflavanones as potent aromatase inhibitors: synthesis and biological evaluation. |
Upres Ea 4021 Biomol�Cules Et Th�Rapies Anti-Tumorales |
18271519 |
65 |
Novel sulfonanilide analogs decrease aromatase activity in breast cancer cells: synthesis, biological evaluation, and ligand-based pharmacophore identification. |
The Ohio State University |
17511439 |
24 |
Synthesis and biological evaluation of (+/-)-abyssinone II and its analogues as aromatase inhibitors for chemoprevention of breast cancer. |
Purdue University |
16190763 |
9 |
Structure-activity relationships of new A,D-ring modified steroids as aromatase inhibitors: design, synthesis, and biological activity evaluation. |
University of Oporto |
12930139 |
22 |
Fluorine substitution can block CYP3A4 metabolism-dependent inhibition: identification of (S)-N-[1-(4-fluoro-3- morpholin-4-ylphenyl)ethyl]-3- (4-fluorophenyl)acrylamide as an orally bioavailable KCNQ2 opener devoid of CYP3A4 metabolism-dependent inhibition. |
Bristol-Myers Squibb Pharmaceutical Research Institute |
1578485 |
19 |
Synthesis and evaluation of a new series of mechanism-based aromatase inhibitors. |
Centre De Recherches Roussel-Uclaf |
1875347 |
23 |
Synthesis and biochemical studies of 16- or 19-substituted androst-4-enes as aromatase inhibitors. |
Tohoku College of Pharmacy |
1825337 |
22 |
Fadrozole hydrochloride: a potent, selective, nonsteroidal inhibitor of aromatase for the treatment of estrogen-dependent disease. |
Ciba-Geigy |
2231592 |
36 |
Mechanism and inhibition of cytochrome P-450 aromatase. |
Johns Hopkins University School of Medicine |
2918514 |
17 |
Effects of steroid D-ring modification on suicide inactivation and competitive inhibition of aromatase by analogues of androsta-1,4-diene-3,17-dione. |
Washington University |
2677377 |
3 |
Is there a case for P-450 inhibitors in cancer treatment? |
Janssen Research Foundation |
2909733 |
6 |
Interactions of thiol-containing androgens with human placental aromatase. |
University of Washington |
6827528 |
1 |
Analogues of aminoglutethimide: selective inhibition of cholesterol side-chain cleavage. |
TBA |
22386564 |
43 |
Optimization of the aromatase inhibitory activities of pyridylthiazole analogues of resveratrol. |
Purdue University |
22335894 |
10 |
New aromatase inhibitors from the 3-pyridyl arylether and 1-aryl pyrrolo[2,3-c]pyridine series. |
Novartis Institutes For Biomedical Research |
22115839 |
42 |
Optimizing thiadiazole analogues of resveratrol versus three chemopreventive targets. |
Purdue University |
22079757 |
13 |
Discovery of a novel class of aldol-derived 1,2,3-triazoles: potent and selective inhibitors of human cytochrome P450 19A1 (aromatase). |
Mcmaster University |
21978950 |
28 |
Design, synthesis, and biological evaluation of callophycin A and analogues as potential chemopreventive and anticancer agents. |
University of Hawaii At Hilo |
21937153 |
46 |
Recent progress in synthesis and bioactivity studies of indolizines. |
University of Botswana |
21703734 |
68 |
Synthesis and structure-activity relationship of 1- and 2-substituted-1,2,3-triazole letrozole-based analogues as aromatase inhibitors. |
Universit£ |
21604760 |
31 |
Structure-based design of potent aromatase inhibitors by high-throughput docking. |
Universita` Di Modena E Reggio Emilia |
21497425 |
13 |
Lead optimization of 4-imidazolylflavans: new promising aromatase inhibitors. |
Upres Ea 4021 Biomol�Cules Et Th�Rapies Anti-Tumorales |
21384875 |
67 |
Fine-tuning the selectivity of aldosterone synthase inhibitors: structure-activity and structure-selectivity insights from studies of heteroaryl substituted 1,2,5,6-tetrahydropyrrolo[3,2,1-ij]quinolin-4-one derivatives. |
Saarland University |
21341743 |
42 |
Design, synthesis, and biological evaluation of imidazolyl derivatives of 4,7-disubstituted coumarins as aromatase inhibitors selective over 17-a-hydroxylase/C17-20 lyase. |
Universita` Degli Studi Di Bari Aldo Moro |
21261296 |
6 |
Bioactive compounds from the fern Lepisorus contortus. |
Yunnan Normal University |
24900302 |
27 |
Hybrid Dual Aromatase-Steroid Sulfatase Inhibitors with Exquisite Picomolar Inhibitory Activity |
TBA |
21129965 |
18 |
N-(Pyridin-3-yl)benzamides as selective inhibitors of human aldosterone synthase (CYP11B2). |
Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland |
20926163 |
32 |
Molecular docking and QSAR study on steroidal compounds as aromatase inhibitors. |
Tianjin University of Science and Technology |
20638757 |
89 |
Exploring benzcyclo derivatives as potent aromatase inhibitors using ligand-based modeling studies. |
University of Calcutta |
20684610 |
73 |
Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prostate cancer. |
Saarland University |
19824618 |
1 |
Aspergillusol A, an alpha-glucosidase inhibitor from the marine-derived fungus Aspergillus aculeatus. |
Institute and The Center For Environmental Health |
19500885 |
10 |
An efficient steroid pharmacophore-based strategy to identify new aromatase inhibitors. |
Universidade De Coimbra |
18939864 |
3 |
Monodictyochromes A and B, Dimeric Xanthone Derivatives from the Marine Algicolous Fungus Monodictys putredinis. |
University of Bonn |
19608417 |
26 |
Synthesis and biochemical evaluation of a range of sulfonated derivatives of 4-hydroxybenzyl imidazole as highly potent inhibitors of rat testicular 17alpha-hydroxylase/17,20-lyase (P-450(17alpha)). |
University of The West of Scotland |
| 8 |
The synthesis of N-aryl androsterone pyrazoles as aromatase inhibitors |
TBA |
| 4 |
Synthesis of 7α-substituted androstenediones by a 1,4-conjugate addition approach |
TBA |
| 1 |
Molecular modelling of inhibitors of aromatase — a novel approach |
TBA |
19072235 |
98 |
Fast three dimensional pharmacophore virtual screening of new potent non-steroid aromatase inhibitors. |
Universidade De Coimbra |
19049427 |
98 |
In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-1H-quinolin-2-one derivatives. |
Saarland University |
18782670 |
39 |
CYP19 (aromatase): exploring the scaffold flexibility for novel selective inhibitors. |
Università |
18763754 |
57 |
Novel aldosterone synthase inhibitors with extended carbocyclic skeleton by a combined ligand-based and structure-based drug design approach. |
Saarland University |
18672861 |
91 |
Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization on potency and selectivity. |
Saarland University |
18640836 |
9 |
Synthesis of 6- or 4-functionalized indoles via a reductive cyclization approach and evaluation as aromatase inhibitors. |
Université |
18558747 |
5 |
Xanthones from the botanical dietary supplement mangosteen (Garcinia mangostana) with aromatase inhibitory activity. |
University of Illinois At Chicago |
18192087 |
9 |
Evaluation of ursolic acid isolated from Ilex paraguariensis and derivatives on aromatase inhibition. |
Universidade Federal Do Rio Grande Do Sul (Ufrgs) |
16643058 |
7 |
Interference by naturally occurring fatty acids in a noncellular enzyme-based aromatase bioassay. |
University of Illinois At Chicago |
11678652 |
16 |
Aromatase inhibitors from Broussonetia papyrifera. |
University of Illinois At Chicago |
17585752 |
10 |
Imidazolylmethylbenzophenones as highly potent aromatase inhibitors. |
TBA |
17315855 |
7 |
Synthesis and biological evaluation of selective aromatase expression regulators in breast cancer cells. |
The Ohio State University |
17291041 |
7 |
Potential cancer chemopreventive in vitro activities of monomeric xanthone derivatives from the marine algicolous fungus Monodictys putredinis. |
University of Bonn |
16854084 |
19 |
Lead optimization providing a series of flavone derivatives as potent nonsteroidal inhibitors of the cytochrome P450 aromatase enzyme. |
University of Bologna |
16480277 |
18 |
Novel sulfonanilide analogues suppress aromatase expression and activity in breast cancer cells independent of COX-2 inhibition. |
The Ohio State University |
16380254 |
9 |
Synthesis and biological evaluation of 5-[(aryl)(1H-imidazol-1-yl)methyl]-1H-indoles: potent and selective aromatase inhibitors. |
Nantes University |
15380230 |
5 |
Synthesis and evaluation of 4-triazolylflavans as new aromatase inhibitors. |
Upres Ea 1085 BiomoléCules Et Cibles Cellulaires Tumorales |
14584934 |
15 |
Identification of a potent and selective 5-HT(6) antagonist: one-step synthesis of (E)-3-(benzenesulfonyl)-2- (methylsulfanyl)pyrido[1,2-a]pyrimidin-4-ylidenamine from 2-(benzenesulfonyl)-3,3-bis(methylsulfanyl)acrylonitrile. |
Bristol-Myers Squibb Pharmaceutical Research Institute |
12699753 |
12 |
Preparation and pharmacological profile of 7-(alpha-azolylbenzyl)-1H-indoles and indolines as new aromatase inhibitors. |
Ufr Des Sciences Pharmaceutiques |
12270163 |
5 |
Design, synthesis and evaluation of 4-imidazolylflavans as new leads for aromatase inhibition. |
Upres Ea 1085 |
11909717 |
7 |
New aromatase inhibitors. Synthesis and inhibitory activity of pyridinyl-substituted flavanone derivatives. |
Upres Ea 1085 |
11262078 |
19 |
A new class of nonsteroidal aromatase inhibitors: design and synthesis of chromone and xanthone derivatives and inhibition of the P450 enzymes aromatase and 17 alpha-hydroxylase/C17,20-lyase. |
University of Bologna |
32435378 |
4 |
Targeting Orthosteric and Allosteric Pockets of Aromatase via Dual-Mode Novel Azole Inhibitors. |
Alma Mater Studiorum-University of Bologna |
11087568 |
55 |
Synthesis and evaluation of 17-aliphatic heterocycle-substituted steroidal inhibitors of 17alpha-hydroxylase/C17-20-lyase (P450 17). |
University of The Saarland |
27567077 |
28 |
Synthesis and aromatase inhibitory evaluation of 4-N-nitrophenyl substituted amino-4H-1,2,4-triazole derivatives. |
Key Laboratory of Industrial Fermentation Microbiology (Tianjin University of Science & Technology) |
32302132 |
74 |
Design and Characterization of the First Selective and Potent Mechanism-Based Inhibitor of Cytochrome P450 4Z1. |
University of Washington |
31255926 |
46 |
Sulfamates in drug design and discovery: Pre-clinical and clinical investigations. |
University of Sharjah |
31129450 |
72 |
Estrogen signaling: An emanating therapeutic target for breast cancer treatment. |
Indian Institute of Technology (Bhu) |
10450990 |
8 |
1-[(Benzofuran-2-yl)phenylmethyl]-triazoles and -tetrazoles - potent competitive inhibitors of aromatase. |
Cardiff University |
30852901 |
16 |
C-6?- vs C-7?-Substituted Steroidal Aromatase Inhibitors: Which Is Better? Synthesis, Biochemical Evaluation, Docking Studies, and Structure-Activity Relationships. |
University of Coimbra |
30822713 |
7 |
Rational design of allosteric modulators of the aromatase enzyme: An unprecedented therapeutic strategy to fight breast cancer. |
Cnr-Iom-Democritos C/O International School For Advanced Studies (Sissa) |
10091679 |
9 |
New selective nonsteroidal aromatase inhibitors: synthesis and inhibitory activity of 2,3 or 5-(alpha-azolylbenzyl)-1H-indoles. |
Nantes |
31416738 |
38 |
Synthesis, molecular docking, and QSAR study of bis-sulfonamide derivatives as potential aromatase inhibitors. |
Srinakharinwirot University |
9871704 |
8 |
Design and synthesis of a new type of non steroidal human aromatase inhibitors. |
Centre D'Etudes Et De Recherche Sur Le MéDicament De Normandie |
31536895 |
27 |
Indole: A privileged scaffold for the design of anti-cancer agents. |
Hunan University of Science and Technology |
30952594 |
13 |
Synthesis of ?-methylstilbenes using an aqueous Wittig methodology and application toward the development of potent human aromatase inhibitors. |
Mcmaster University |
9379446 |
10 |
6 beta-Propynyl-substituted steroids: mechanism-based enzyme-activated irreversible inhibitors of aromatase. |
University of Minnesota |
9357513 |
15 |
6-Chloro-5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]- indoline (SB-242084): the first selective and brain penetrant 5-HT2C receptor antagonist. |
Smithkline Beecham Pharmaceuticals |
31732252 |
5 |
Synthesis, biological evaluation, and docking study of indole aryl sulfonamides as aromatase inhibitors. |
"G. D'Annunzio" University |
8765515 |
37 |
3- and 4-pyridylalkyl adamantanecarboxylates: inhibitors of human cytochrome P450(17 alpha) (17 alpha-hydroxylase/C17,20-lyase). Potential nonsteroidal agents for the treatment of prostatic cancer. |
Cancer Research Campaign Centre For Cancer Therapeutics |
31312408 |
49 |
Development of Highly Selective Pyrimidine-Based Aldosterone Synthase (CYP11B2) Inhibitors. |
Selenity Therapeutics |
8632407 |
43 |
Tetrahydronaphthalenes: influence of heterocyclic substituents on inhibition of steroid enzymes P450 arom and P450 17. |
UniversitäT De Saarlandes |
26540564 |
30 |
Discovery of N-[5-(6-Chloro-3-cyano-1-methyl-1H-indol-2-yl)-pyridin-3-ylmethyl]-ethanesulfonamide, a Cortisol-Sparing CYP11B2 Inhibitor that Lowers Aldosterone in Human Subjects. |
Novartis Institutes For Biomedical Research |
8496907 |
8 |
Aromatase inhibitors: synthesis, biological activity, and binding mode of azole-type compounds. |
Ciba-Geigy |
8340925 |
18 |
Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering. |
Syntex Discovery Research |
8176709 |
32 |
6-Alkyl- and 6-arylandrost-4-ene-3,17-diones as aromatase inhibitors. Synthesis and structure-activity relationships. |
Tohoku College of Pharmacy |
8176705 |
25 |
Aromatase inhibitors. Syntheses and structure-activity studies of novel pyridyl-substituted indanones, indans, and tetralins. |
UniversitäT Des Saarlandes |
8035427 |
51 |
Synthesis of androst-5-en-7-ones and androsta-3,5-dien-7-ones and their related 7-deoxy analogs as conformational and catalytic probes for the active site of aromatase. |
Tohoku College of Pharmacy |
7783141 |
28 |
Pyridyl-substituted tetrahydrocyclopropa[a]naphthalenes: highly active and selective inhibitors of P450 arom. |
UniversitäT Des Saarlandes |
7636845 |
8 |
Synthesis, structure elucidation, and biochemical evaluation of 7 alpha- and 7 beta-arylaliphatic-substituted androst-4-ene-3,17-diones as inhibitors of aromatase. |
Ohio State University |
7608911 |
35 |
Novel steroidal inhibitors of human cytochrome P45017 alpha (17 alpha-hydroxylase-C17,20-lyase): potential agents for the treatment of prostatic cancer. |
Institute of Cancer Research |
7562951 |
4 |
Probing the hydrophobic pocket of the active site of aromatase with 4-phenoxy-7 alpha-(phenylthio)-4-androstene-3,17-dione. |
University of Minnesota |
7473546 |
61 |
Esters of 3-pyridylacetic acid that combine potent inhibition of 17 alpha-hydroxylase/C17,20-lyase (cytochrome P45017 alpha) with resistance to esterase hydrolysis. |
Crc Laboratory |
3754286 |
17 |
Synthesis and biochemical evaluation of analogues of aminoglutethimide based on phenylpyrrolidine-2,5-dione. |
TBA |
3735304 |
14 |
Aromatase inhibitors. Synthesis and evaluation of mammary tumor inhibiting activity of 3-alkylated 3-(4-aminophenyl)piperidine-2,6-diones. |
TBA |
3625703 |
38 |
Analogues of 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione as selective inhibitors of aromatase: derivatives with variable 1-alkyl and 3-alkyl substituents. |
TBA |
29525337 |
27 |
Studies on non-steroidal inhibitors of aromatase enzyme; 4-(aryl/heteroaryl)-2-(pyrimidin-2-yl)thiazole derivatives. |
Istanbul Medipol University |
29254646 |
17 |
Dihydrobenzisoxazole-4-one compounds are novel selective inhibitors of aldosterone synthase (CYP11B2) with in vivo activity. |
Boehringer Ingelheim Pharmaceuticals |
29153737 |
10 |
Structure-activity relationships and docking studies of synthetic 2-arylindole derivatives determined with aromatase and quinone reductase 1. |
University of Hawai'I At Hilo |
28319389 |
31 |
Potential Antiosteoporotic Natural Product Lead Compounds That Inhibit 17?-Hydroxysteroid Dehydrogenase Type 2. |
University of Basel |
29202405 |
21 |
Potent aromatase inhibitors and molecular mechanism of inhibitory action. |
Yunnan University |
29137864 |
36 |
Synthesis, molecular docking, and QSAR study of sulfonamide-based indoles as aromatase inhibitors. |
Srinakharinwirot University |
2391706 |
22 |
Crystallographic and molecular modeling studies on 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione and its butyl analogue, inhibitors of mammalian aromatase. Comparison with natural substrates: prediction of enantioselectivity for N-alkyl derivatives. |
Institute of Cancer Research |
2296006 |
7 |
Synthesis and biochemical studies of 7-substituted 4,6-androstadiene-3,17-diones as aromatase inhibitors. |
Ohio State University |
2231604 |
69 |
Inhibition of enzymes of estrogen and androgen biosynthesis by esters of 4-pyridylacetic acid. |
Institute of Cancer Research |
29803730 |
42 |
Design and synthesis of functionalized piperazin-1yl-(E)-stilbenes as inhibitors of 17?-hydroxylase-C17,20-lyase (Cyp17). |
Temple University |
28651982 |
47 |
Design and optimization of highly-selective, broad spectrum fungal CYP51 inhibitors. |
Viamet Pharmaceuticals |
2033599 |
8 |
Novel time-dependent inhibitors of human placental aromatase. |
Marion Merrell Dow Research Institute |
2016709 |
8 |
Inhibition of human placental aromatase by novel homologated 19-oxiranyl and 19-thiiranyl steroids. |
Johns Hopkins University School of Medicine |
2016706 |
29 |
Synthesis and aromatase inhibitory activity of novel 1-(4-aminophenyl)-3-azabicyclo[3.1.0]hexane- and -[3.1.1]heptane-2,4- diones. |
Ciba-Geigy |
1895288 |
23 |
New aromatase inhibitors. Synthesis and biological activity of pyridyl-substituted tetralone derivatives. |
UniversitäT Des Saarlandes |
28427017 |
5 |
Aromatase inhibitors and apoptotic inducers: Design, synthesis, anticancer activity and molecular modeling studies of novel phenothiazine derivatives carrying sulfonamide moiety as hybrid molecules. |
King Saud University |
1613747 |
10 |
Synthesis and aromatase inhibition of 3-cycloalkyl-substituted 3-(4-aminophenyl)piperidine-2,6-diones. |
UniversitäT Des Saarlandes |
28416132 |
96 |
Discovery of indazole aldosterone synthase (CYP11B2) inhibitors as potential treatments for hypertension. |
Merck Research Laboratories |
1495014 |
36 |
Stereoisomers of ketoconazole: preparation and biological activity. |
Syntex Research |
28512028 |
20 |
Evaluation of synthesized coumarin derivatives on aromatase inhibitory activity. |
Health Sciences University of Hokkaido |
1433182 |
11 |
Conformational analysis of the aromatase inhibitor 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione (rogletimide) and discovery of potent 5-alkyl derivatives. |
Institute of Cancer Research |
27439119 |
16 |
Structure-Based Screening of Uncharted Chemical Space for Atypical Adenosine Receptor Agonists |
Uppsala University |
8824284 |
43 |
Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior. |
Bayer |
2137193 |
4 |
Molecular cloning and expression of a dopamine D2 receptor from human retina. |
National Institute of Neurological Disorders and Stroke |
18096504 |
19 |
URB602 inhibits monoacylglycerol lipase and selectively blocks 2-arachidonoylglycerol degradation in intact brain slices. |
University of California Irvine |
18022559 |
4 |
Inverse in silico screening for identification of kinase inhibitor targets. |
University of Munich |
10980448 |
3 |
Human liver glycogen phosphorylase inhibitors bind at a new allosteric site. |
Pfizer |
18849972 |
45 |
Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase. |
The Scripps Research Institute |
18249537 |
56 |
Development of pyridopyrimidines as potent Akt1/2 inhibitors. |
Merck Research Laboratories |
16420054 |
24 |
Structure-activity study of brassinin derivatives as indoleamine 2,3-dioxygenase inhibitors. |
Bryn Mawr College |
18318466 |
41 |
Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors. |
Bryn Mawr College |
16951187 |
11 |
AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts. |
Amgen |
18763753 |
29 |
Design, synthesis, and biological evaluation of potent c-Met inhibitors. |
Amgen |
18637666 |
7 |
Novel 4-aminoquinolines active against chloroquine-resistant and sensitive P. falciparum strains that also inhibit botulinum serotype A. |
University of Belgrade |
18630890 |
24 |
A pentacyclic aurora kinase inhibitor (AKI-001) with high in vivo potency and oral bioavailability. |
Genentech |
18665584 |
32 |
Structure based development of phenylimidazole-derived inhibitors of indoleamine 2,3-dioxygenase. |
Bryn Mawr College |
18656911 |
39 |
Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a novel cyclin dependent kinase inhibitor using fragment-based X-ray crystallography and structure based drug design. |
Astex |
18570366 |
9 |
Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor. |
Methylgene |
18522384 |
11 |
Chemically induced dimerization of human nonpancreatic secretory phospholipase A2 by bis-indole derivatives. |
Peking University |
17850059 |
195 |
N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. |
Montana State University |
15355974 |
6 |
Crystal structure of avian aminoimidazole-4-carboxamide ribonucleotide transformylase in complex with a novel non-folate inhibitor identified by virtual ligand screening. |
The Scripps Research Institute |
18433114 |
28 |
4-benzyl-1H-imidazoles with oxazoline termini as histamine H3 receptor agonists. |
Vu University Amsterdam |
18419108 |
37 |
2-Amino-1,3-thiazol-4(5H)-ones as Potent and Selective 11beta-Hydroxysteroid Dehydrogenase Type 1 Inhibitors: Enzyme-Ligand Co-Crystal Structure and Demonstration of Pharmacodynamic Effects in C57Bl/6 Mice. |
Biovitrum |
16821792 |
16 |
Design and synthesis of novel 2-amino-5-hydroxyindole derivatives that inhibit human 5-lipoxygenase. |
Friedrich Alexander University Erlangen |
17274610 |
263 |
Indanylacetic acid derivatives carrying 4-thiazolyl-phenoxy tail groups, a new class of potent PPAR alpha/gamma/delta pan agonists: synthesis, structure-activity relationship, and in vivo efficacy. |
Bayer Healthcare Pharmaceuticals |