325 articles for thisTarget

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PMID	Data	Article Title	Organization
28259528	177	Structural insights of SmKDAC8 inhibitors: Targeting Schistosoma epigenetics through a combined structure-based 3D QSAR, in vitro and synthesis strategy.	Washington University
28259626	90	Perfluorinated hydroxamic acids are potent and selective inhibitors of HDAC-like enzymes from Pseudomonas aeruginosa.	University Of Applied Sciences Darmstadt
28213282	57	Design, synthesis and biological evaluation of thienopyrimidine hydroxamic acid based derivatives as structurally novel histone deacetylase (HDAC) inhibitors.	Chinese Academy Of Sciences
28026946	2	Monascustin, an Unusual¿-Lactam from Red Yeast Rice.	Beijing Union University
28131715	10	Design, synthesis and evaluation of antiproliferative activity of melanoma-targeted histone deacetylase inhibitors.	Georgia Institute Of Technology
28523102	19	Design and Synthesis of Mercaptoacetamides as Potent, Selective, and Brain Permeable Histone Deacetylase 6 Inhibitors.	University Of Illinois At Chicago
28109947	424	Design and synthesis of benzodiazepine analogs as isoform-selective human lysine deacetylase inhibitors.	Washington University
28038324	48	Ring-opened tetrahydro-¿-carbolines display cytotoxicity and selectivity with histone deacetylase isoforms.	Taipei Medical University
15149697	10	Thiol-based SAHA analogues as potent histone deacetylase inhibitors.	Nagoya City University
15109664	4	Three new cyclostellettamines, which inhibit histone deacetylase, from a marine sponge of the genus Xestospongia.	The University Of Tokyo
15109636	14	Stereodefined and polyunsaturated inhibitors of histone deacetylase based on (2E,4E)-5-arylpenta-2,4-dienoic acid hydroxyamides.	University College London
14643318	23	Novel histone deacetylase inhibitors: design, synthesis, enzyme inhibition, and binding mode study of SAHA-based non-hydroxamates.	Nagoya City University
14592473	35	Heterocyclic ketones as inhibitors of histone deacetylase.	Abbott Laboratories
14552787	28	A novel series of histone deacetylase inhibitors incorporating hetero aromatic ring systems as connection units.	Abbott Laboratories
12951120	32	Alpha-keto amides as inhibitors of histone deacetylase.	Abbott Laboratories
12749893	37	Indole amide hydroxamic acids as potent inhibitors of histone deacetylases.	Abbott Laboratories
12419380	24	Trifluoromethyl ketones as inhibitors of histone deacetylase.	Abbott Laboratories
12270175	13	Succinimide hydroxamic acids as potent inhibitors of histone deacetylase (HDAC).	Abbott Laboratories
28337317	30	Structural Requirements of HDAC Inhibitors: SAHA Analogues Modified at the C2 Position Display HDAC6/8 Selectivity.	Wayne State University
27541357	58	Design and Synthesis of Janus Kinase 2 (JAK2) and Histone Deacetlyase (HDAC) Bispecific Inhibitors Based on Pacritinib and Evidence of Dual Pathway Inhibition in Hematological Cell Lines.	National University Of Singapore
28057407	76	Bifunctional conjugates with potent inhibitory activity towards cyclooxygenase and histone deacetylase.	Georgia Institute Of Technology
27769671	66	Synthesis and investigation of novel 6-(1,2,3-triazol-4-yl)-4-aminoquinazolin derivatives possessing hydroxamic acid moiety for cancer therapy.	Tsinghua University
27344487	16	2-(Phenylsulfonyl)quinoline N-hydroxyacrylamides as potent anticancer agents inhibiting histone deacetylase.	Taipei Medical University
27717544	75	Targeting prostate cancer with compounds possessing dual activity as androgen receptor antagonists and HDAC6 inhibitors.	Integral Biosciences
27665180	14	Design and synthesis of novel HDAC8 inhibitory 2,5-disubstituted-1,3,4-oxadiazoles containing glycine and alanine hybrids with anti cancer activity.	Acharya Nagarjuna University
27650925	15	Synthesis of a selective HDAC6 inhibitor active in neuroblasts.	University Of Geneva
27606546	218	Design, Synthesis, and Biological Evaluation of First-in-Class Dual Acting Histone Deacetylases (HDACs) and Phosphodiesterase 5 (PDE5) Inhibitors for the Treatment of Alzheimer's Disease.	University Of Navarra
27597246	17	Design, synthesis and in vitro evaluation of amidoximes as histone deacetylase inhibitors for cancer therapy.	Qilu Normal University
27377864	55	Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors.	Broad Institute Of Mit And Harvard
27186676	186	Development of Purine-Based Hydroxamic Acid Derivatives: Potent Histone Deacetylase Inhibitors with Marked in Vitro and in Vivo Antitumor Activities.	West China Hospital Of Sichuan University
27142751	22	Targeting epigenetic reader and eraser: Rational design, synthesis and in vitro evaluation of dimethylisoxazoles derivatives as BRD4/HDAC dual inhibitors.	China Pharmaceutical University
27190592	24	Discovery of a Selective Series of Inhibitors of Plasmodium falciparum HDACs.	Irbm Science Park
27177826	2	Synergistic potentiation of (-)-lomaiviticin A cytotoxicity by the ATR inhibitor VE-821.	Yale University
26937828	137	Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis.	Martin-Luther University Of Halle-Wittenberg
26996372	10	Identification of new quinic acid derivatives as histone deacetylase inhibitors by fluorescence-based cellular assay.	Sungkyunkwan University
26890116	30	Biphenyl-4-yl-acrylohydroxamic acids: Identification of a novel indolyl-substituted HDAC inhibitor with antitumor activity.	University Of Milan
27060764	30	Computer-aided identification of new histone deacetylase 6 selective inhibitor with anti-sepsis activity.	Sungkyunkwan University
26443078	108	Discovery of Selective Histone Deacetylase 6 Inhibitors Using the Quinazoline as the Cap for the Treatment of Cancer.	Sichuan University
26890114	56	Design, synthesis and biological evaluation of bisthiazole-based trifluoromethyl ketone derivatives as potent HDAC inhibitors with improved cellular efficacy.	Shanghai Institute Of Materia Medica
26681404	40	Design and Synthesis of Simplified Largazole Analogues as Isoform-Selective Human Lysine Deacetylase Inhibitors.	Washington University
26653328	67	Synthesis and Biological Investigation of Oxazole Hydroxamates as Highly Selective Histone Deacetylase 6 (HDAC6) Inhibitors.	Albert-Ludwigs-University Of Freiburg
26907204	34	Design and synthesis of a new generation of substituted purine hydroxamate analogs as histone deacetylase inhibitors.	Shandong University
26705137	31	Design, Synthesis, and Pharmacological Evaluation of Novel N-Acylhydrazone Derivatives as Potent Histone Deacetylase 6/8 Dual Inhibitors.	Universidade Federal De Alfenas
26629857	44	Novel leucine ureido derivatives as aminopeptidase N inhibitors. Design, synthesis and activity evaluation.	Fudan University
26814680	71	Identification of N-(6-mercaptohexyl)-3-(4-pyridyl)-1H-pyrazole-5-carboxamide and its disulfide prodrug as potent histone deacetylase inhibitors with in vitro and in vivo anti-tumor efficacy.	Shenyang Pharmaceutical University
26804233	38	Dissecting structure-activity-relationships of crebinostat: Brain penetrant HDAC inhibitors for neuroepigenetic regulation.	Massachusetts General Hospital
26706171	138	Novel thiol-based histone deacetylase inhibitors bearing 3-phenyl-1H-pyrazole-5-carboxamide scaffold as surface recognition motif: Design, synthesis and SAR study.	Shenyang Pharmaceutical University
26689485	18	Orally available stilbene derivatives as potent HDAC inhibitors with antiproliferative activities and antitumor effects in human tumor xenografts.	Orchid Chemicals & Pharmaceuticals
26741358	56	Design, synthesis and biological evaluation of N-phenylquinazolin-4-amine hybrids as dual inhibitors of VEGFR-2 and HDAC.	China Pharmaceutical University
26629860	58	Synthesis, biological characterization and molecular modeling insights of spirochromanes as potent HDAC inhibitors.	European Institute Of Oncology
26753813	22	Design and synthesis of an activity-based protein profiling probe derived from cinnamic hydroxamic acid.	University Of Minnesota
26639764	17	Synthesis and biological activity of diisothiocyanate-derived mercapturic acids.	Wroclaw University Of Technology
26005563	2	Discovery of a new class of histone deacetylase inhibitors with a novel zinc binding group.	Medical University Of South Carolina
26475519	40	Hybrids from 4-anilinoquinazoline and hydroxamic acid as dual inhibitors of vascular endothelial growth factor receptor-2 and histone deacetylase.	China Pharmaceutical University
26241876	1	Triazine as a promising scaffold for its versatile biological behavior.	Thapar University
26481659	18	New macrocyclic analogs of the natural histone deacetylase inhibitor FK228; design, synthesis and preliminary biological evaluation.	Ronzoni Institute For Chemical And Biochem. Research
26376355	14	Investigation on the ZBG-functionality of phenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase inhibitors.	University Of Milan
26331334	99	Discovery of Novel Class I Histone Deacetylase Inhibitors with Promising in Vitro and in Vivo Antitumor Activities.	Guangzhou Institute Of Biomedicine And Health
26086931	38	Strategies for the Discovery of Target-Specific or Isoform-Selective Modulators.	Shandong University
26264503	46	Discovery of 1-hydroxypyridine-2-thiones as selective histone deacetylase inhibitors and their potential application for treating leukemia.	University Of Minnesota
26287310	87	Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit.	University College London
26211462	71	Design, synthesis and biological evaluation of isoquinoline-based derivatives as novel histone deacetylase inhibitors.	The Walter And Eliza Hall Institute Of Medical Research
25637120	94	Evaluation of histone deacetylase inhibitors (HDACi) as therapeutic leads for human African trypanosomiasis (HAT).	St. Jude Children'S Research Hospital
22344701	30	Biocatalytic synthesis and structure elucidation of cyclized metabolites of the deacetylase inhibitor panobinostat (LBH589).	Novartis Institutes For Biomedical Research
25147612	25	Modulation of Activity Profiles for Largazole-Based HDAC Inhibitors through Alteration of Prodrug Properties.	University Of Florida
25261927	80	Design, synthesis and biological evaluation of 4-anilinothieno[2,3-d]pyrimidine-based hydroxamic acid derivatives as novel histone deacetylase inhibitors.	The Walter And Eliza Hall Institute Of Medical Research
26054247	48	Modular synthesis and biological activity of pyridyl-based analogs of the potent Class I Histone Deacetylase Inhibitor Largazole.	Colorado State University
26140961	11	Design, synthesis and antiproliferative activities of novel benzamides derivatives as HDAC inhibitors.	Academy Of Military Medical Sciences
26100440	6	Design, synthesis and preliminary biological evaluation of indoline-2,3-dione derivatives as novel HDAC inhibitors.	Shandong University
25993269	140	Novel Bioactive Hybrid Compound Dual Targeting Estrogen Receptor and Histone Deacetylase for the Treatment of Breast Cancer.	Key Laboratory Of Combinatorial Biosynthesis And Drug Discovery (Wuhan University)
25953722	102	Discovery, bioactivity and docking simulation of Vorinostat analogues containing 1,2,4-oxadiazole moiety as potent histone deacetylase inhibitors and antitumor agents.	Southeast University
26035239	1	Natural Product Primary Sulfonamides and Primary Sulfamates.	Griffith University
25974739	17	Dual-Mode HDAC Prodrug for Covalent Modification and Subsequent Inhibitor Release.	University Of California
25815139	18	Discovery of Novel Multiacting Topoisomerase I/II and Histone Deacetylase Inhibitors.	Fujian University Of Traditional Chinese Medicine
25971769	25	Discovery of bicyclic pyrazoles as class III histone deacetylase SIRT1 and SIRT2 inhibitors.	Methylgene
25906087	14	Design, synthesis, and antitumor evaluation of novel histone deacetylase inhibitors equipped with a phenylsulfonylfuroxan module as a nitric oxide donor.	Shandong University
25905694	24	Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells.	Istituto Ortopedico Rizzoli (Ior)
25811792	32	Discovery of Orally Available Runt-Related Transcription Factor 3 (RUNX3) Modulators for Anticancer Chemotherapy by Epigenetic Activation and Protein Stabilization.	Yonsei University
25874326	60	Discovery and preliminary evaluation of 2-aminobenzamide and hydroxamate derivatives containing 1,2,4-oxadiazole moiety as potent histone deacetylase inhibitors.	Southeast University
25899338	37	Design and structure activity relationship of tumor-homing histone deacetylase inhibitors conjugated to folic and pteroic acids.	Georgia Institute Of Technology
25805446	30	Design, synthesis and biological evaluation of colchicine derivatives as novel tubulin and histone deacetylase dual inhibitors.	East China Normal University
25800646	40	Macrocyclic compounds as anti-cancer agents: design and synthesis of multi-acting inhibitors against HDAC, FLT3 and JAK2.	Central South University
25734520	104	Design and synthesis of orally bioavailable aminopyrrolidinone histone deacetylase 6 inhibitors.	Roche Innovation Center Shanghai
25113875	14	Indole-3-ethylsulfamoylphenylacrylamides: potent histone deacetylase inhibitors with anti-inflammatory activity.	Taipei Medical University
25070421	33	Evaluation of class I HDAC isoform selectivity of largazole analogues.	Duke University
25042254	7	Novel inhibitors of human histone deacetylases: design, synthesis and bioactivity of 3-alkenoylcoumarines.	H�Pital Kirchberg
25022972	24	Bicyclic tetrapeptides as potent HDAC inhibitors: effect of aliphatic loop position and hydrophobicity on inhibitory activity.	University Of Rajshahi
24999749	1	A potent HDAC inhibitor, 1-alaninechlamydocin, from a Tolypocladium sp. induces G2/M cell cycle arrest and apoptosis in MIA PaCa-2 cells.	University Of Oklahoma
24997578	41	Design and synthesis of CHAP31, trapoxin B and HC-toxin based bicyclic tetrapeptides disulfide as potent histone deacetylase inhibitors.	University Of Rajshahi
24972008	36	1,3,4-Oxadiazole-containing histone deacetylase inhibitors: anticancer activities in cancer cells.	Sapienza University Of Rome
24864038	112	Design and synthesis of novel and highly-active pan-histone deacetylase (pan-HDAC) inhibitors.	Nippon Pharmaceutical Chemicals
25563890	49	Hydroxamic acid based histone deacetylase inhibitors with confirmed activity against the malaria parasite.	R&D Sigma-Tau Industrie Farmaceutiche Riunite
25462271	33	Development of 3-hydroxycinnamamide-based HDAC inhibitors with potent in vitro and in vivo anti-tumor activity.	Shandong University
25455492	22	Aurones as histone deacetylase inhibitors: identification of key features.	University Of Geneva
25454270	82	Histone deacetylase inhibitors derived from 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine and related heterocycles selective for the HDAC6 isoform.	TBA
25380299	61	Methyl effect in azumamides provides insight into histone deacetylase inhibition by macrocycles.	Technical University Of Denmark
25238284	52	Identification of a novel aminotetralin class of HDAC6 and HDAC8 selective inhibitors.	Roche Pharmaceutical Research And Early Development
25233084	247	ST7612AA1, a thioacetate-¿(¿-lactam carboxamide) derivative selected from a novel generation of oral HDAC inhibitors.	R&D Sigma-Tau Industrie Farmaceutiche Riunite
25221651	12	Novel antiproliferative chimeric compounds with marked histone deacetylase inhibitory activity.	University Of Bologna
25218912	103	Design, synthesis, and biological evaluation of 1, 3-disubstituted-pyrazole derivatives as new class I and IIb histone deacetylase inhibitors.	Chinese Academy Of Sciences
25182565	21	Design, synthesis and evaluation of novel HDAC inhibitors as potential antitumor agents.	Shanghai Huilun Life Sciences & Technology
25176189	7	Design, synthesis and biological evaluation ofß-boswellic acid based HDAC inhibitors as inducers of cancer cell death.	Csir-Indian Institute Of Integrative Medicine
24944733	101	Potent and orally efficacious bisthiazole-based histone deacetylase inhibitors.	Chinese National Center For Drug Screening
24900884	14	Late-Stage C-H Coupling Enables Rapid Identification of HDAC Inhibitors: Synthesis and Evaluation of NCH-31 Analogues.	Nagoya University
24900838	30	Delayed and Prolonged Histone Hyperacetylation with a Selective HDAC1/HDAC2 Inhibitor.	Merck Research Laboratories
24766560	16	Azaindolylsulfonamides, with a more selective inhibitory effect on histone deacetylase 6 activity, exhibit antitumor activity in colorectal cancer HCT116 cells.	Taipei Medical University
24588105	56	Synthesis and evaluation of new Hsp90 inhibitors based on a 1,4,5-trisubstituted 1,2,3-triazole scaffold.	Universit£
24565573	35	4,5,6,7-Tetrahydro-isoxazolo-[4,5-c]-pyridines as a new class of cytotoxic Hsp90 inhibitors.	Universit£
24742384	90	Influence of the adamantyl moiety on the activity of biphenylacrylohydroxamic acid-based HDAC inhibitors.	Universit£
24694055	35	Discovery of the first N-hydroxycinnamamide-based histone deacetylase 1/3 dual inhibitors with potent oral antitumor activity.	Shandong University
24015327	42	Development of a chimeric c-Src kinase and HDAC inhibitor.	University Of Michigan
23570542	48	Design and synthesis of dual-action inhibitors targeting histone deacetylases and 3-hydroxy-3-methylglutaryl coenzyme A reductase for cancer treatment.	National Taiwan University
23547652	27	3-Hydroxypyridin-2-thione as novel zinc binding group for selective histone deacetylase inhibition.	Georgia Institute Of Technology
23368884	80	Potent and selective inhibition of histone deacetylase 6 (HDAC6) does not require a surface-binding motif.	Broad Institute Of Mit And Harvard
23493449	8	Development of	Shandong University
24900575	31	Biological evaluation of new largazole analogues: alteration of macrocyclic scaffold with click chemistry.	Chinese Academy Of Sciences
23313638	6	Total synthesis of bicyclic depsipeptides spiruchostatins C and D and investigation of their histone deacetylase inhibitory and antiproliferative activities.	Tohoku Pharmaceutical University
23252603	35	Histone deacetylase (HDAC) inhibitors with a novel connecting unit linker region reveal a selectivity profile for HDAC4 and HDAC5 with improved activity against chemoresistant cancer cells.	Heinrich Heine Universit£T
23206867	12	Design, synthesis and bioevalution of novel benzamides derivatives as HDAC inhibitors.	The General Hospital Of Chinese People'S Liberation Army
22932316	8	Amide-based derivatives ofß-alanine hydroxamic acid as histone deacetylase inhibitors: attenuation of potency through resonance effects.	University Of Sydney
23089527	6	The structural requirements of histone deacetylase inhibitors: suberoylanilide hydroxamic acid analogs modified at the C6 position.	Wayne State University
23116147	30	Rapid discovery of highly potent and selective inhibitors of histone deacetylase 8 using click chemistry to generate candidate libraries.	Kyoto Prefectural University Of Medicine
23061376	63	Pharmacokinetic optimization of class-selective histone deacetylase inhibitors and identification of associated candidate predictive biomarkers of hepatocellular carcinoma tumor response.	Roche R & D Center China
23009203	39	Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth.	University Of Illinois At Chicago
23010266	24	Novel histone deacetylase 8 ligands without a zinc chelating group: exploring an 'upside-down' binding pose.	University Of Illinois At Chicago
24900543	27	Macrocyclic peptoid-Peptide hybrids as inhibitors of class I histone deacetylases.	TBA
23021104	32	Cyclic tetrapeptides with thioacetate tails or intramolecular disulfide bridge as potent inhibitors of histone deacetylases.	Graduate School Of Life Science And Systems Engineering
22642300	160	Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors.	Kyoto Prefectural University Of Medicine
24900500	21	Discovery of HDAC Inhibitors That Lack an Active Site Zn(2+)-Binding Functional Group.	TBA
22771007	64	Design, synthesis, modeling, biological evaluation and photoaffinity labeling studies of novel series of photoreactive benzamide probes for histone deacetylase 2.	University Of Illinois At Chicago
22738629	47	CCLab--a multi-objective genetic algorithm based combinatorial library design software and an application for histone deacetylase inhibitor design.	Chinese Academy Of Sciences
22705022	32	Synthesis, biological evaluation and molecular docking studies of 3-(1,3-diphenyl-1H-pyrazol-4-yl)-N-phenylacrylamide derivatives as inhibitors of HDAC activity.	Nanjing University
22439863	21	Synthesis and biological evaluation of 1-arylsulfonyl-5-(N-hydroxyacrylamide)indoles as potent histone deacetylase inhibitors with antitumor activity in vivo.	Taipei Medical University
22280363	104	Defining the mechanism of action and enzymatic selectivity of psammaplin A against its epigenetic targets.	Imperial College
22541394	30	Appraisal of GABA and PABA as linker: design and synthesis of novel benzamide based histone deacetylase inhibitors.	Guru Ghasidas University
22260166	17	Dual targeting of histone deacetylase and topoisomerase II with novel bifunctional inhibitors.	Georgia Institute Of Technology
22465091	28	A novel series of l-2-benzyloxycarbonylamino-8-(2-pyridyl)-disulfidyloctanoic acid derivatives as histone deacetylase inhibitors: design, synthesis and molecular modeling study.	Dalian University Of Technology
22165909	48	Second-generation histone deacetylase 6 inhibitors enhance the immunosuppressive effects of Foxp3+ T-regulatory cells.	University Of Illinois At Chicago
22276693	5	Trichostatin analogues JBIR-109, JBIR-110, and JBIR-111 from the marine sponge-derived Streptomyces sp. RM72.	Biomedicinal Information Research Center (Birc)
21984958	83	Potential Agents for Treating Cystic Fibrosis: Cyclic Tetrapeptides that Restore Trafficking and Activity of ¿F508-CFTR.	TBA
21650221	57	Optimization of the in vitro cardiac safety of hydroxamate-based histone deacetylase inhibitors.	Novartis Institutes For Biomedical Research
21874153	54	Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin.	Broad Institute Of Harvard And Mit
20472442	25	On the inhibition of histone deacetylase 8.	University Of Notre Dame
20392637	159	Benzimidazole and imidazole inhibitors of histone deacetylases: Synthesis and biological activity.	Takeda California
19705846	100	Discovery of potent and selective histone deacetylase inhibitors via focused combinatorial libraries of cyclic alpha3beta-tetrapeptides.	The Scripps Research Institute
18809328	64	Optimization of a series of potent and selective ketone histone deacetylase inhibitors.	Irbm/Merck Research Laboratories
18397826	18	Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells.	Waseda University
18381238	4	Novel uracil-based 2-aminoanilide and 2-aminoanilide-like derivatives: histone deacetylase inhibition and in-cell activities.	Sapienza University Of Rome
18381239	1	Synthesis and biological evaluation of histone deacetylase inhibitors that are based on FR235222: a cyclic tetrapeptide scaffold.	San Diego State University
18054239	54	Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs).	University Of Freiburg
18182289	127	Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2).	Merck Research Laboratories
18160287	23	Design and synthesis of 4-[(s-triazin-2-ylamino)methyl]-N-(2-aminophenyl)-benzamides and their analogues as a novel class of histone deacetylase inhibitors.	Methylgene
18247554	134	Histone deacetylase inhibitors: from bench to clinic.	Menarini Ricerche
16987657	45	A series of novel, potent, and selective histone deacetylase inhibitors.	Irbm/Merck Research Laboratories
15454224	15	Novel histone deacetylase inhibitors: cyclic tetrapeptide with trifluoromethyl and pentafluoroethyl ketones.	Crest Research Project
14613312	106	Histone deacetylase inhibitors.	Aton Pharma
14584932	23	Discovery of (aryloxopropenyl)pyrrolyl hydroxyamides as selective inhibitors of class IIa histone deacetylase homologue HD1-A.	Sapienza University Of Rome
11206439	51	Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 2.	Merck Research Laboratories
11206438	48	Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 1.	Merck Research Laboratories
22321215	16	Anti-tumor activity of new orally bioavailable 2-amino-5-(thiophen-2-yl)benzamide-series histone deacetylase inhibitors, possessing an aqueous soluble functional group as a surface recognition domain.	Kansai University
21417419	5	Discovery, synthesis, and pharmacological evaluation of spiropiperidine hydroxamic acid based derivatives as structurally novel histone deacetylase (HDAC) inhibitors.	Dac
22182579	110	Synthesis and biochemical analysis of 2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro-N-hydroxy-octanediamides as inhibitors of human histone deacetylases.	University Of Applied Sciences
21721525	8	In vivo PET imaging of histone deacetylases by 18F-suberoylanilide hydroxamic acid (18F-SAHA).	Harvard Medical School
21548582	57	Design, synthesis, docking, and biological evaluation of novel diazide-containing isoxazole- and pyrazole-based histone deacetylase probes.	University Of Illinois At Chicago
21924799	38	Design, synthesis and primary activity assay of tripeptidomimetics as histone deacetylase inhibitors with linear linker and branched cap group.	Shandong University
21889343	6	The structural requirements of histone deacetylase inhibitors: Suberoylanilide hydroxamic acid analogs modified at the C3 position display isoform selectivity.	Wayne State University
21875796	24	2,5-Disubstituted-1,3,4-oxadiazoles/thiadiazole as surface recognition moiety: design and synthesis of novel hydroxamic acid based histone deacetylase inhibitors.	Guru Ghasidas University
21634430	218	Discovery of (2E)-3-{2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profile.	S*Bio
21712146	20	Synthesis and evaluation of aliphatic-chain hydroxamates capped with osthole derivatives as histone deacetylase inhibitors.	Taipei Medical University
21723733	12	Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors.	Novartis Institutes For Biomedical Research
21745740	10	Synthesis and biological evaluation of piperamide analogues as HDAC inhibitors.	East China Normal University
21742496	85	The design, synthesis and structure-activity relationships of novel isoindoline-based histone deacetylase inhibitors.	Novartis Institutes For Biomedical Research
21696956	243	A novel HDAC inhibitor with a hydroxy-pyrimidine scaffold.	Broad Institute Of Harvard And Mit
21080647	27	Discovery of 2-(6-{[(6-fluoroquinolin-2-yl)methyl]amino}bicyclo[3.1.0]hex-3-yl)-N-hydroxypyrimidine-5-carboxamide (CHR-3996), a class I selective orally active histone deacetylase inhibitor.	Chroma Therapeutics
21417297	220	Oxime amides as a novel zinc binding group in histone deacetylase inhibitors: synthesis, biological activity, and computational evaluation.	Universita` Degli Studi Di Siena
21256006	11	Structure and property based design, synthesis and biological evaluation of¿-lactam based HDAC inhibitors.	Yonsei University
21145737	12	Application of p21 and klf2 reporter gene assays to identify selective histone deacetylase inhibitors for cancer therapy.	Roche R & D Center China
21073160	143	Non-Natural Macrocyclic Inhibitors of Histone Deacetylases: Design, Synthesis, and Activity	TBA
21080629	153	Novel chimeric histone deacetylase inhibitors: a series of lapatinib hybrides as potent inhibitors of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and histone deacetylase activity.	University Of Regensburg
20947351	24	Inhibitors selective for HDAC6 in enzymes and cells.	The University Of Queensland
19966789	40	Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis.	The Scripps Research Institute
20637529	15	Design and synthesis of novel isoxazole-based HDAC inhibitors.	Università
20491440	12	Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues.	Universidade De Vigo
20452226	15	New orally bioavailable 2-aminobenzamide-type histone deacetylase inhibitor possessing a (2-hydroxyethyl)(4-(thiophen-2-yl)benzyl)amino group.	Kansai University
20223566	23	Inside HDAC with HDAC inhibitors.	Universit£
20451378	107	Acylurea connected straight chain hydroxamates as novel histone deacetylase inhibitors: Synthesis, SAR, and in vivo antitumor activity.	S*Bio
20381359	17	Synthesis and biological activity of cyclotetrapeptide analogues of the natural HDAC inhibitor FR235222.	Universit£
20158243	2	Gymnochromes E and F, cytotoxic phenanthroperylenequinones from a deep-water crinoid, Holopus rangii.	Florida Atlantic University
20205394	44	Conformational refinement of hydroxamate-based histone deacetylase inhibitors and exploration of 3-piperidin-3-ylindole analogues of dacinostat (LAQ824).	Novartis Institutes For Biomedical Research
20143840	28	Biological and biophysical properties of the histone deacetylase inhibitor suberoylanilide hydroxamic acid are affected by the presence of short alkyl groups on the phenyl ring.	Umr Cnrs 6026-Universit£
20055418	78	Synthesis and biological evaluation of triazol-4-ylphenyl-bearing histone deacetylase inhibitors as anticancer agents.	University Of Illinois At Chicago
20045316	18	Bicyclic peptides as potent inhibitors of histone deacetylases: optimization of alkyl loop length.	Graduate School Of Life Science And Systems Engineering
20143778	70	Discovery of 7-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide (CUDc-101) as a potent multi-acting HDAC, EGFR, and HER2 inhibitor for the treatment of cancer.	Curis
19906529	22	Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors.	Ortho-Biotech Oncology Research & Development
19822426	4	Novel N-hydroxybenzamide-based HDAC inhibitors with branched CAP group.	China Pharmaceutical University
19699639	58	Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors.	Methylgene
19888759	42	Identification of novel, selective, and stable inhibitors of class II histone deacetylases. Validation studies of the inhibition of the enzymatic activity of HDAC4 by small molecules as a novel approach for cancer therapy.	Istituto Di Ricerche Di Biologia Molecolare
19359173	51	Exploring bis-(indolyl)methane moiety as an alternative and innovative CAP group in the design of histone deacetylase (HDAC) inhibitors.	Sigma-Tau Research And Development
19136179	22	3D-QSAR studies of HDACs inhibitors using pharmacophore-based alignment.	China Pharmaceutical University
19362838	16	Design and synthesis of novel hybrid benzamide-peptide histone deacetylase inhibitors.	The Scripps Research Institute
19457659	22	Non-isotopic dual parameter competition assay suitable for high-throughput screening of histone deacetylases.	University Of G£Ttingen
19441846	35	Discovery of a potent class I selective ketone histone deacetylase inhibitor with antitumor activity in vivo and optimized pharmacokinetic properties.	Irbm/Merck Research Laboratories
19419863	58	Isoxazole moiety in the linker region of HDAC inhibitors adjacent to the Zn-chelating group: effects on HDAC biology and antiproliferative activity.	University Of Illinois At Chicago
19419205	28	Design, synthesis, and biological activity of boronic acid-based histone deacetylase inhibitors.	Nagoya City University
19410459	33	Histone deacetylase inhibitors with a primary amide zinc binding group display antitumor activity in xenograft model.	Irbm/Merck Research Laboratories
19301902	104	Design of chimeric histone deacetylase- and tyrosine kinase-inhibitors: a series of imatinib hybrides as potent inhibitors of wild-type and mutant BCR-ABL, PDGF-Rbeta, and histone deacetylases.	University Of Regensburg
19285395	66	N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors.	R&D Sigma-Tau
19272776	63	Synthesis and evaluation of lysine derived sulfamides as histone deacetylase inhibitors.	Methylgene
19268585	30	Exploring the pharmacokinetic properties of phosphorus-containing selective HDAC 1 and 2 inhibitors (SHI-1:2).	Merck Research Laboratories
19181524	46	N-Hydroxy-1,2-disubstituted-1H-benzimidazol-5-yl acrylamides as novel histone deacetylase inhibitors: design, synthesis, SAR studies, and in vivo antitumor activity.	S*Bio
19114304	44	SAR and biological evaluation of analogues of a small molecule histone deacetylase inhibitor N-(2-aminophenyl)-4-((4-(pyridin-3-yl)pyrimidin-2-ylamino)methyl)benzamide (MGCD0103).	Methylgene
19084395	45	Sulfamides as novel histone deacetylase inhibitors.	Methylgene
19007204	2	Histone deacetylase inhibitors through click chemistry.	The Ohio State University
18952417	50	Studies of the metabolic stability in cells of 5-(trifluoroacetyl)thiophene-2-carboxamides and identification of more stable class II histone deacetylase (HDAC) inhibitors.	Irbm-Merck Research Laboratories Rome
18951790	109	SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2).	Merck Research Laboratories
18930398	117	2-Trifluoroacetylthiophene oxadiazoles as potent and selective class II human histone deacetylase inhibitors.	Irbm-Merck Research Laboratories Rome
18701301	38	Design, synthesis and biological evaluation of novel compounds with conjugated structure as anti-tumor agents.	China Pharmaceutical University
18672316	41	Novel amide derivatives as inhibitors of histone deacetylase: design, synthesis and SAR.	Institute Of Organic Synthesis
18642892	76	Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6.	University Of Illinois At Chicago
18558669	119	Trithiocarbonates as a novel class of HDAC inhibitors: SAR studies, isoenzyme selectivity, and pharmacological profiles.	Nycomed
18207391	28	4-(Heteroarylaminomethyl)-N-(2-aminophenyl)-benzamides and their analogs as a novel class of histone deacetylase inhibitors.	Methylgene
18060775	67	Optimization of biaryl Selective HDAC1&2 Inhibitors (SHI-1:2).	Merck Research Laboratories
17977726	19	N-(2-Amino-phenyl)-4-(heteroarylmethyl)-benzamides as new histone deacetylase inhibitors.	Methylgene
17900911	21	Interaction of aliphatic cap group in inhibition of histone deacetylases by cyclic tetrapeptides.	Graduate School Of Life Science And Systems Engineering
17881232	42	Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework.	Graduate School Of Life Science And Systems Engineering
17761416	53	The discovery of 6-amino nicotinamides as potent and selective histone deacetylase inhibitors.	Merck Research Laboratories
17691763	20	2-aroylindoles and 2-aroylbenzofurans with N-hydroxyacrylamide substructures as a novel series of rationally designed histone deacetylase inhibitors.	University Of Regensburg
17606370	2	Trithiocarbonates: exploration of a new head group for HDAC inhibitors.	Altana Pharma
17588744	18	Design, synthesis, and evaluation of isoindolinone-hydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors.	The University Of Tokyo
17576064	30	Benzo[b]thiophene-based histone deacetylase inhibitors.	Merck Research Laboratories
17555962	26	Design of novel histone deacetylase inhibitors.	Merck Research Laboratories
17539623	65	Functional differences in epigenetic modulators-superiority of mercaptoacetamide-based histone deacetylase inhibitors relative to hydroxamates in cortical neuron neuroprotection studies.	University Of Illinois At Chicago
17507219	17	Aminosuberoyl hydroxamic acids (ASHAs): a potent new class of HDAC inhibitors.	Merck Research Laboratories
17447750	4	Bispyridinium dienes: histone deacetylase inhibitors with selective activities.	Universidade De Vigo
17419603	6	Design and synthesis of a potent histone deacetylase inhibitor.	Virginia Tech
17346959	14	Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors.	Ithaca College
17257837	3	Identification of a potent and stable antiproliferative agent by the prodrug formation of a thiolate histone deacetylase inhibitor.	Nagoya City University
17107790	40	Identification and optimisation of a series of substituted 5-pyridin-2-yl-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibitors.	Argenta Discovery
17095213	25	Identification and optimisation of a series of substituted 5-(1H-pyrazol-3-yl)-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibitors.	Argenta Discovery
17046252	17	Structure-activity relationships of aryloxyalkanoic acid hydroxyamides as potent inhibitors of histone deacetylase.	University College London
16884291	12	Highly potent and selective histone deacetylase 6 inhibitors designed based on a small-molecular substrate.	Nagoya City University
16713259	30	Substituted N-(2-aminophenyl)-benzamides, (E)-N-(2-aminophenyl)-acrylamides and their analogues: novel classes of histone deacetylase inhibitors.	Methylgene
16137884	6	Design and synthesis of phthalimide-type histone deacetylase inhibitors.	The University Of Tokyo Yayoi
15189037	6	On the function of the 14 A long internal cavity of histone deacetylase-like protein: implications for the design of histone deacetylase inhibitors.	University Of Notre Dame
14698179	58	Design, synthesis, and activity of HDAC inhibitors with a N-formyl hydroxylamine head group.	The Scripps Research Institute
14684344	49	(2-amino-phenyl)-amides of omega-substituted alkanoic acids as new histone deacetylase inhibitors.	Methylgene
12593661	34	Development of potential antitumor agents. Synthesis and biological evaluation of a new set of sulfonamide derivatives as histone deacetylase inhibitors.	Methylgene
12061890	26	Structurally simple trichostatin A-like straight chain hydroxamates as potent histone deacetylase inhibitors.	Methylgene
11597413	46	Design and synthesis of a novel class of histone deacetylase inhibitors.	Methylgene
29518312	78	Discovery of N1-(4-((7-Cyclopentyl-6-(dimethylcarbamoyl)-7 H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)phenyl)- N8-hydroxyoctanediamide as a Novel Inhibitor Targeting Cyclin-dependent Kinase 4/9 (CDK4/9) and Histone Deacetlyase1 (HDAC1) against Malignant Cancer.	Nankai University
29499113	77	Class I HDAC Inhibitors Display Different Antitumor Mechanism in Leukemia and Prostatic Cancer Cells Depending on Their p53 Status.	Medical University Of South Carolina
28532668	10	Design, synthesis and biological evaluation of 4-piperazinyl-containing Chidamide derivatives as HDACs inhibitors.	Shanghai Institute Of Pharmaceutical Industry
28416100	19	Synthesis and biological evaluation of largazole zinc-binding group analogs.	Duke University
28415009	51	Selective HDAC inhibitors with potent oral activity against leukemia and colorectal cancer: Design, structure-activity relationship and anti-tumor activity study.	Shandong University
28395150	30	4-Indolyl-N-hydroxyphenylacrylamides as potent HDAC class I and IIB inhibitors in vitro and in vivo.	Taipei Medical University (Tmu)
28391133	6	Design, synthesis and biological evaluation of novel hydroxamates and 2-aminobenzamides as potent histone deacetylase inhibitors and antitumor agents.	Beijing University Of Chemical Technology
28885834	80	Small Molecule Inhibitors Simultaneously Targeting Cancer Metabolism and Epigenetics: Discovery of Novel Nicotinamide Phosphoribosyltransferase (NAMPT) and Histone Deacetylase (HDAC) Dual Inhibitors.	Second Military Medical University
28336407	8	Development of N-hydroxycinnamamide-based HDAC inhibitors with improved HDAC inhibitory activity and in vitro antitumor activity.	Shandong University
28581289	20	Alkoxyurea-Based Histone Deacetylase Inhibitors Increase Cisplatin Potency in Chemoresistant Cancer Cell Lines.	Heinrich-Heine-Universit£T D£Sseldorf
28574690	98	Design, Multicomponent Synthesis, and Anticancer Activity of a Focused Histone Deacetylase (HDAC) Inhibitor Library with Peptoid-Based Cap Groups.	Heinrich-Heine-Universit£T D£Sseldorf
19558346	15	Synthesis of a novel series of benzylether-containing cinnamoyl derivatives as histone deacetylase inhibitors.	Shandong University
28196613	34	Potent and Selective EphA4 Agonists for the Treatment of ALS.	Sanford Burnham Prebys Medical Discovery Institute
28057325	50	Design, synthesis and biological screening of some novel celecoxib and etoricoxib analogs with promising COX-2 selectivity, anti-inflammatory activity and gastric safety profile.	Fayoum University
27416889	35	Design, synthesis, and preliminary bioactivity evaluation of N(1) -hydroxyterephthalamide derivatives with indole cap as novel histone deacetylase inhibitors.	Shandong University
25699604	74	Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases.	University Of Florida College Of Medicine
7915318	120	Biochemical and pharmacological characterization of high-affinity trimetoquinol analogs on guinea pig and human beta adrenergic receptor subtypes: evidence for partial agonism.	Ohio State University
17718722	30	Bipiperidinyl carboxylic acid amides as potent, selective, and functionally active CCR4 antagonists.	Pfizer
1662620	12	Characterization of a guanosine-nucleotide-binding-protein-coupled receptor for pituitary adenylate-cyclase-activating polypeptide on plasma membranes from rat brain.	Georg-August-University
1586393	43	Localization and function of the D3 dopamine receptor.	U. 109
1554381	19	Agonist activity of 2- and 5'-substituted adenosine analogs and their N6-cycloalkyl derivatives at A1- and A2-adenosine receptors coupled to adenylate cyclase.	National Institutes Of Diabetes And Digestive And Kidney Diseases
1501121	12	Biochemical and pharmacological properties of SR 46349B, a new potent and selective 5-hydroxytryptamine2 receptor antagonist.	Sanofi Recherche
282646	50	Histamine H1 receptors identified in mammalian brain membranes with [3H]mepyramine.	TBA
37098	14	Binding characteristics of 3H-prazosin to rat brain alpha-adrenergic receptors.	TBA
18291323	20	Probing FtsZ and tubulin with C8-substituted GTP analogs reveals differences in their nucleotide binding sites.	University Of Amsterdam
20545322	6	Site-specific orthogonal labeling of the carboxy terminus of alpha-tubulin.	Binghamton University
17825569	48	The influence of modifications in imide fragment structure on 5-HT(1A) and 5-HT(7) receptor affinity and in vivo pharmacological properties of some new 1-(m-trifluoromethylphenyl)piperazines.	Polish Academy Of Sciences
12643924	7	Structure-based de novo design of non-nucleoside adenosine deaminase inhibitors.	Fujisawa Pharmaceutical
15664859	16	Structure-based design, synthesis and biochemical testing of novel and potent Smac peptido-mimetics.	University Of Michigan
15566305	14	Potent N-(1,3-thiazol-2-yl)pyridin-2-amine vascular endothelial growth factor receptor tyrosine kinase inhibitors with excellent pharmacokinetics and low affinity for the hERG ion channel.	Merck Research Laboratories
25019596	24	Quinolone-based HDAC inhibitors.	Orchid Chemicals & Pharmaceuticals
11472208	24	Structure-based design, synthesis, and biological evaluation of conformationally restricted novel 2-alkylthio-6-[1-(2,6-difluorophenyl)alkyl]-3,4-dihydro-5-alkylpyrimidin-4(3H)-ones as non-nucleoside inhibitors of HIV-1 reverse transcriptase.	Sapienza University Of Rome
11543677	20	Design and synthesis of potent C(2)-symmetric diol-based HIV-1 protease inhibitors: effects of fluoro substitution.	Linkoping University