266 articles for thisTarget

---

The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
28284805	10	Novel 2-phenyl-4,5,6,7-tetrahydro[b]benzothiophene analogues as selective COX-2 inhibitors: Design, synthesis, anti-inflammatory evaluation, and molecular docking studies.	Institute of Chemical Technology
27837994	30	Synthesis, biological evaluation, docking study and ulcerogenicity profiling of some novel quinoline-2-carboxamides as dual COXs/LOX inhibitors endowed with anti-inflammatory activity.	Al-Azhar University
28038322	38	Synthesis, anti-inflammatory, cyclooxygenases inhibitions assays and histopathological study of poly-substituted 1,3,5-triazines: Confirmation of regiospecific pyrazole cyclization by HMBC.	Beni-Suef University
28057407	76	Bifunctional conjugates with potent inhibitory activity towards cyclooxygenase and histone deacetylase.	Georgia Institute of Technology
27916468	36	Design, synthesis and analgesic/anti-inflammatory evaluation of novel diarylthiazole and diarylimidazole derivatives towards selective COX-1 inhibitors with better gastric profile.	Beni-Suef University
27842798	66	Synthesis, COX-1/2 inhibition activities and molecular docking study of isothiazolopyridine derivatives.	Wroclaw Medical University
27720548	16	Synthesis, structure determination, and biological evaluation of phenylsulfonyl hydrazide derivatives as potential anti-inflammatory agents.	Kyung Hee University
27191614	4	The therapeutic voyage of pyrazole and its analogs: A review.	Jamia Hamdard
27131067	24	Synthesis of new thiazolo-celecoxib analogues as dual cyclooxygenase-2/15-lipoxygenase inhibitors: Determination of regio-specific different pyrazole cyclization by 2D NMR.	Beni-Suef University
27325447	6	Isomeric iodinated analogs of nimesulide: Synthesis, physicochemical characterization, cyclooxygenase-2 inhibitory activity, and transport across Caco-2 cells.	Tohoku Medical and Pharmaceutical University
27344214	16	Design, synthesis of 2,3-disubstitued 4(3H)-quinazolinone derivatives as anti-inflammatory and analgesic agents: COX-1/2 inhibitory activities and molecular docking studies.	King Saud University
27019010	48	Rational Design of Small Peptides for Optimal Inhibition of Cyclooxygenase-2: Development of a Highly Effective Anti-Inflammatory Agent.	Guru Nanak Dev University
26999325	30	Synthesis, anti-inflammatory, analgesic and COX-1/2 inhibition activities of anilides based on 5,5-diphenylimidazolidine-2,4-dione scaffold: Molecular docking studies.	King Saud University
26898334	16	Design and synthesis of [(125)I]Pyricoxib: A novel (125)I-labeled cyclooxygenase-2 (COX-2) inhibitors.	University of Alberta
26774927	120	Potent multitarget FAAH-COX inhibitors: Design and structure-activity relationship studies.	Fondazione Istituto Italiano Di Tecnologia
27025563	12	Synthesis, anti-inflammatory, analgesic, COX-1/2 inhibition activities and molecular docking study of pyrazoline derivatives.	University of Mansoura
26850006	10	Anti-inflammatory and antioxidant properties of a novel resveratrol-salicylate hybrid analog.	University of Alberta
26691756	38	Synthesis, cyclooxygenase inhibition, anti-inflammatory evaluation and ulcerogenic liability of new 1,3,5-triarylpyrazoline and 1,5-diarylpyrazole derivatives as selective COX-2 inhibitors.	Beni-Suef University
26455657	12	Isomeric methoxy analogs of nimesulide for development of brain cyclooxygense-2 (COX-2)-targeted imaging agents: Synthesis, in vitro COX-2-inhibitory potency, and cellular transport properties.	Tohoku Pharmaceutical University
26316467	2	Dicarabrol, a new dimeric sesquiterpene from Carpesium abrotanoides L.	Hunan University of Chinese Medicine
26117820	18	Synthesis, characterization, evaluation and molecular dynamics studies of 5, 6-diphenyl-1,2,4-triazin-3(2H)-one derivatives bearing 5-substituted 1,3,4-oxadiazole as potential anti-inflammatory and analgesic agents.	Indian Institute of Technology (Banaras Hindu University)
26081289	14	Novel (pyrazolyl)benzenesulfonamides with a nitric oxide-releasing moiety as selective cyclooxygenase-2 inhibitors.	Technische Universitat Dresden
25956953	51	Indole based peptidomimetics as anti-inflammatory and anti-hyperalgesic agents: Dual inhibition of 5-LOX and COX-2 enzymes.	Guru Nanak Dev University
25768707	17	General role of the amino and methylsulfamoyl groups in selective cyclooxygenase(COX)-1 inhibition by 1,4-diaryl-1,2,3-triazoles and validation of a predictive pharmacometric PLS model.	Universit£
25980909	16	Compounds from the insect Blaps japanensis with COX-1 and COX-2 inhibitory activities.	Chinese Academy of Sciences
25549551	66	Structure-based design of phthalimide derivatives as potential cyclooxygenase-2 (COX-2) inhibitors: anti-inflammatory and analgesic activities.	King Saud University
25868745	16	Novel thiazolo[3,2-b]-1,2,4-triazoles derived from naproxen with analgesic/anti-inflammatory properties: Synthesis, biological evaluation and molecular modeling studies.	Hacettepe University
25819096	16	Five new phorbol esters with cytotoxic and selective anti-inflammatory activities from Croton tiglium.	Hunan University of Chinese Medicine
25575659	124	SAR-studies of¿-secretase modulators with PPAR¿-agonistic and 5-lipoxygenase-inhibitory activity for Alzheimer's disease.	Goethe-University Frankfurt
25147154	18	Design, synthesis and molecular docking study of novel quinoxalin-2(1H)-ones as anti-tumor active agents with inhibition of tyrosine kinase receptor and studying their cyclooxygenase-2 activity.	Dokki
25016374	31	Potent, orally available, selective COX-2 inhibitors based on 2-imidazoline core.	Griffith University
24938495	75	Pharmacological evaluation and docking studies ofa,ß-unsaturated carbonyl based synthetic compounds as inhibitors of secretory phospholipase A2, cyclooxygenases, lipoxygenase and proinflammatory cytokines.	Universiti Kebangsaan Malaysia
24631898	17	Rational design, synthesis and evaluation of chromone-indole and chromone-pyrazole based conjugates: identification of a lead for anti-inflammatory drug.	Guru Nanak Dev University
24576797	8	Part I. Synthesis, biological evaluation and docking studies of new 2-furylbenzimidazoles as antiangiogenic agents.	National Research Centre, Dokki
25462246	20	Synthesis and evaluation of new indole-based chalcones as potential antiinflammatory agents.	Anadolu University
25444084	40	Synthesis of novel pyrazole?thiadiazole hybrid as potential potent and selective cyclooxygenase-2 (COX-2) inhibitors.	Kle University
25408841	108	Design of Fluorine-Containing 3,4-Diarylfuran-2(5H)-ones as Selective COX-1 Inhibitors.	Vanderbilt University School of Medicine
25221653	24	Propyphenazone-based analogues as prodrugs and selective cyclooxygenase-2 inhibitors.	Minia University
25219899	16	Synthesis, biological evaluation and docking analysis of 3-methyl-1-phenylchromeno[4,3-c]pyrazol-4(1H)-ones as potential cyclooxygenase-2 (COX-2) inhibitors.	National Institute of Pharmaceutical Education and Research
24983538	16	Novel 1-[4-(Aminosulfonyl)phenyl]-1H-1,2,4-triazole derivatives with remarkable selective COX-2 inhibition: design, synthesis, molecular docking, anti-inflammatory and ulcerogenicity studies.	Minia University
24900871	8	2-(2-Arylphenyl)benzoxazole As a Novel Anti-Inflammatory Scaffold: Synthesis and Biological Evaluation.	National Institute of Pharmaceutical Education and Research (NIPER)
24844534	46	Tetra- and pentacyclic triterpene acids from the ancient anti-inflammatory remedy frankincense as inhibitors of microsomal prostaglandin E(2) synthase-1.	University of Tuebingen
24780593	46	Design and synthesis of novel 2-phenyl-5-(1,3-diphenyl-1H-pyrazol-4-yl)-1,3,4-oxadiazoles as selective COX-2 inhibitors with potent anti-inflammatory activity.	Shoolini University
24763362	22	Synthesis, biological evaluation, molecular docking and theoretical evaluation of ADMET properties of nepodin and chrysophanol derivatives as potential cyclooxygenase (COX-1, COX-2) inhibitors.	National Institute of Pharmaceutical Education and Research
24751552	20	Synthesis, pharmacological screening and in silico studies of new class of Diclofenac analogues as a promising anti-inflammatory agents.	K.L.E.U'S College of Pharmacy
24656662	33	Synthesis, biological evaluation, and docking analysis of a novel family of 1-methyl-1H-pyrrole-2,5-diones as highly potent and selective cyclooxygenase-2 (COX-2) inhibitors.	Kyung Hee University
24650702	16	Structure-activity relationship of celecoxib and rofecoxib for the membrane permeabilizing activity.	Keio University
24631895	14	1-(4-Methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1H-1,2,4-triazole-3-carboxamides: synthesis, molecular modeling, evaluation of their anti-inflammatory activity and ulcerogenicity.	Minia University
24631365	10	Synthesis and biological evaluation of new pyrazolone-pyridazine conjugates as anti-inflammatory and analgesic agents.	Cairo University
23219856	7	Synthesis and biological evaluation of some 5-arylidene-2-(1,3-thiazol-2-ylimino)-1,3-thiazolidin-4-ones as dual anti-inflammatory/antimicrobial agents.	Department of Pharmaceutical Chemistry of Aristotle University of Thessaloniki
23200247	30	Hybrid fluorescent conjugates of COX-2 inhibitors: search for a COX-2 isozyme imaging cancer biomarker.	University of Alberta
12383007	100	Inhibitory mode of 1,5-diarylpyrazole derivatives against cyclooxygenase-2 and cyclooxygenase-1: molecular docking and 3D QSAR analyses.	Chinese Academy of Sciences
23043222	125	Identification and characterization of carprofen as a multitarget fatty acid amide hydrolase/cyclooxygenase inhibitor.	Istituto Italiano Di Tecnologia
22916727	18	Design and synthesis of indomethacin analogues that inhibit P-glycoprotein and/or multidrug resistant protein without COX inhibitory activity.	Hokkaido University
23010270	25	Synthesis and pharmacological evaluation of N-substituted 2-(2-oxo-2H-chromen-4-yloxy)propanamide as cyclooxygenase inhibitors.	University of Hyderabad Campus
21800856	50	Lignan derivatives from Krameria lappacea roots inhibit acute inflammation in vivo and pro-inflammatory mediators in vitro.	University of Innsbruck
23047224	24	Molecular modeling, synthesis and screening of some new 4-thiazolidinone derivatives with promising selective COX-2 inhibitory activity.	Hacettepe University
22560838	7	Radiosynthesis of a¹8F-labeled 2,3-diarylsubstituted indole via McMurry coupling for functional characterization of cyclooxygenase-2 (COX-2) in vitro and in vivo.	Helmholtz-Zentrum Dresden-Rossendorf
22091869	6	Binding of ibuprofen, ketorolac, and diclofenac to COX-1 and COX-2 studied by saturation transfer difference NMR.	Faculdade De Ci�Ncias E Tecnologia-Unl
22516672	47	Synthesis, biological evaluation and molecular modeling study of pyrazole and pyrazoline derivatives as selective COX-2 inhibitors and anti-inflammatory agents. Part 2.	University of Mansoura
22475926	39	Synthesis and biological evaluation of isoxazolo[4,5-d]pyridazin-4-(5H)-one analogues as potent anti-inflammatory agents.	University of Hacettepe
21280601	18	Ethanesulfohydroxamic acid ester prodrugs of nonsteroidal anti-inflammatory drugs (NSAIDs): synthesis, nitric oxide and nitroxyl release, cyclooxygenase inhibition, anti-inflammatory, and ulcerogenicity index studies.	University of Alberta
21318094	25	[I]-Celecoxib Analogues as SPECT Tracers of Cyclooxygenase-2 in Inflammation.	TBA
20188577	23	In silico search for multi-target anti-inflammatories in Chinese herbs and formulas.	King'S College London
19880317	50	COX, LOX and platelet aggregation inhibitory properties of Lauraceae neolignans.	Universidad Nacional De Colombia
19500994	18	Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 5-(4-carboxymethylphenyl)-1-(4-methanesulfonylphenyl)-3-trifluoromethyl-1H-pyrazole and its aminosulfonyl analog: Synthesis, biological evaluation and nitric oxide release studies.	University of Alberta
19053751	89	Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.	Eberhard Karls University Tuebingen
15568761	18	Mechanism-based inactivation of COX-1 by red wine m-hydroquinones: a structure-activity relationship study.	University of Pennsylvania School of Medicine
18272371	50	Design, synthesis, and biological evaluation of 1-(4-sulfamylphenyl)-3-trifluoromethyl-5-indolyl pyrazolines as cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) inhibitors.	Temple University
17434872	38	Molecular determinants for the selective inhibition of cyclooxygenase-2 by lumiracoxib.	Vanderbilt Institute For Chemical Biology
18023187	32	Synthesis and cyclooxygenase inhibitory activities of linear 1-(methanesulfonylphenyl or benzenesulfonamido)-2-(pyridyl)acetylene regioisomers.	University of Alberta
18096394	22	Diazen-1-ium-1,2-diolated and nitrooxyethyl nitric oxide donor ester prodrugs of anti-inflammatory (E)-2-(aryl)-3-(4-methanesulfonylphenyl)acrylic acids: synthesis, cyclooxygenase inhibition, and nitric oxide release studies.	University of Alberta
16143531	58	Synthesis and biological evaluation of 1,3-diphenylprop-2-yn-1-ones as dual inhibitors of cyclooxygenases and lipoxygenases.	University of Alberta
15780608	12	Design, synthesis, biological evaluation and molecular docking of curcumin analogues as antioxidant, cyclooxygenase inhibitory and anti-inflammatory agents.	National Institute of Pharmaceutical Education and Research (NIPER)
14584938	48	Design, synthesis, and biological evaluation of 6-substituted-3-(4-methanesulfonylphenyl)-4-phenylpyran-2-ones: a novel class of diarylheterocyclic selective cyclooxygenase-2 inhibitors.	University of Alberta
8831759	16	1-substituted 4-aryl-5-pyridinylimidazoles: a new class of cytokine suppressive drugs with low 5-lipoxygenase and cyclooxygenase inhibitory potency.	Smithkline Beecham Pharmaceuticals
7562922	48	Antiinflammatory 4,5-diarylpyrroles. 2. Activity as a function of cyclooxygenase-2 inhibition.	Dupont Pharmaceuticals
22386983	25	Synthesis and evaluation of fluorobenzoylated di- and tripeptides as inhibitors of cyclooxygenase-2 (COX-2).	University of Alberta
22361134	26	N-1 and C-3 substituted indole Schiff bases as selective COX-2 inhibitors: synthesis and biological evaluation.	University of Alberta
22341941	34	Novel 5-substituted 1H-tetrazoles as cyclooxygenase-2 (COX-2) inhibitors.	University of Alberta
22148253	12	Nitric oxide release is not required to decrease the ulcerogenic profile of nonsteroidal anti-inflammatory drugs.	University of Alberta
22119153	64	Fragment-based design, docking, synthesis, biological evaluation and structure-activity relationships of 2-benzo/benzisothiazolimino-5-aryliden-4-thiazolidinones as cycloxygenase/lipoxygenase inhibitors.	Alexander Technological Education Institute of Thessaloniki
21890358	30	Isomeric acetoxy analogs of celecoxib and their evaluation as cyclooxygenase inhibitors.	University of Alberta
21843935	2	Inhibition of COX-1 activity and COX-2 expression by 3-(4'-geranyloxy-3'-methoxyphenyl)-2-trans propenoic acid and its semi-synthetic derivatives.	Universit£
21873070	29	SAR studies of acidic dual¿-secretase/PPAR¿ modulators.	Goethe-University Frankfurt
21739938	72	Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase.	National Human Genome Research Institute
21641217	10	A diazen-1-ium-1,2-diolated nitric oxide donor ester prodrug of 3-(4-hydroxymethylphenyl)-4-(4-methanesulfonylphenyl)-5H-furan-2-one: synthesis, biological evaluation and nitric oxide release studies.	University of Alberta
19447036	12	Design and synthesis of 3-alkyl-2-aryl-1,3-thiazinan-4-one derivatives as selective cyclooxygenase (COX-2) inhibitors.	Shahid Beheshti University (M.C)
21570309	42	Design, synthesis, and biological evaluation of substituted hydrazone and pyrazole derivatives as selective COX-2 inhibitors: Molecular docking study.	University of Mansoura
21524587	6	Synthesis and evaluation of carbaborane derivatives of indomethacin as cyclooxygenase inhibitors.	Universit£T Leipzig
21319773	8	Natural compound cudraflavone B shows promising anti-inflammatory properties in vitro.	University of Veterinary and Pharmaceutical Sciences Brno
21388719	54	Synthesis, anti-inflammatory activity and COX-1/COX-2 inhibition of novel substituted cyclic imides. Part 1: Molecular docking study.	King Saud University
21349729	44	Syntheses and characterization of nimesulide derivatives for dual enzyme inhibitors of both cyclooxygenase-1/2 and 5-lipoxygenase.	Sun Yat-Sen University
21316237	12	Synthesis and evaluation of 1,5-diaryl-substituted tetrazoles as novel selective cyclooxygenase-2 (COX-2) inhibitors.	University of Alberta
21144750	30	Design of novel N-phenylnicotinamides as selective cyclooxygenase-1 inhibitors.	Nanjing University
20961090	6	Ipomotaosides A-D, resin glycosides from the aerial parts of Ipomoea batatas and their inhibitory activity against COX-1 and COX-2.	Tokushima Bunri University
20727750	9	Synthesis and biological evaluation of indomethacin analogs possessing a N-difluoromethyl-1,2-dihydropyrid-2-one ring system: a search for novel cyclooxygenase and lipoxygenase inhibitors.	University of Alberta
20804197	40	Synthesis, anti-inflammatory activity, and in vitro antitumor effect of a novel class of cyclooxygenase inhibitors: 4-(aryloyl)phenyl methyl sulfones.	Universitat De Barcelona
20691338	24	Design, synthesis and biological evaluation of new (E)- and (Z)-1,2,3-triaryl-2-propen-1-ones as selective COX-2 inhibitors.	Shahid Beheshti University of Medical Sciences
20692174	12	Synthesis, biological evaluation, and docking studies of novel heterocyclic diaryl compounds as selective COX-2 inhibitors.	Gazi University
20655211	18	Triaryl (Z)-olefins suitable for radiolabeling with carbon-11 or fluorine-18 radionuclides for positron emission tomography imaging of cyclooxygenase-2 expression in pathological disease.	University of Alberta
20576432	16	Celecoxib prodrugs possessing a diazen-1-ium-1,2-diolate nitric oxide donor moiety: synthesis, biological evaluation and nitric oxide release studies.	University of Alberta
20527891	7	Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites.	Purdue University
20503989	29	Design, synthesis, and biological evaluation of a novel class of gamma-secretase modulators with PPARgamma activity.	Zafes/Liff/Goethe University Frankfurt
20387815	40	Mono-, di-, and triaryl substituted tetrahydropyrans as cyclooxygenase-2 and tumor growth inhibitors. Synthesis and biological evaluation.	Guru Nanak Dev University
20236826	6	Derivatives of schisandrin with increased inhibitory potential on prostaglandin E(2) and leukotriene B(4) formation in vitro.	University of Graz
20202839	13	Synthesis and biological evaluation of N-difluoromethyl-1,2-dihydropyrid-2-one acetic acid regioisomers: dual inhibitors of cyclooxygenases and 5-lipoxygenase.	University of Alberta
20129783	30	Podophyllotoxin analogues active versus Trypanosoma brucei.	Vanderbilt University School of Medicine
20045320	14	Phenylacetic acid regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.	University of Alberta
20097072	14	Celecoxib analogs possessing a N-(4-nitrooxybutyl)piperidin-4-yl or N-(4-nitrooxybutyl)-1,2,3,6-tetrahydropyridin-4-yl nitric oxide donor moiety: synthesis, biological evaluation and nitric oxide release studies.	University of Alberta
20061161	12	Design, synthesis and biological evaluation of new 2,3-diarylquinoline derivatives as selective cyclooxygenase-2 inhibitors.	Shahid Beheshti University Mc
19560931	15	Synthesis and biological evaluation of new 4-carboxyl quinoline derivatives as cyclooxygenase-2 inhibitors.	Shahid Beheshti University (M.C)
19457595	12	Fenbufen based 3-[5-(substituted aryl)-1,3,4-oxadiazol-2-yl]-1-(biphenyl-4-yl)propan-1-ones as safer antiinflammatory and analgesic agents.	Hamdard University
19592244	61	7-Azaindole-3-acetic acid derivatives: potent and selective CRTh2 receptor antagonists.	Novartis Institutes of Biomedical Research
19481465	31	Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxygenase-mediated LTB4-formation.	Karl-Franzens-Universit£T Graz
19596198	14	Design and synthesis of new 1,3-benzthiazinan-4-one derivatives as selective cyclooxygenase (COX-2) inhibitors.	Shahid Beheshti University (M.C)
	50	Chemistry and pharmacokinetics of diarylthiophenes and terphenyls as selective COX-2 inhibitors	TBA
	10	Structural optimization of alkyl-substituted 2-(7-5H-[1]benzopyrano[2,3-b]pyridyl)propionic acid as anti-inflammatory agents	TBA
19419861	18	Dinitroglyceryl and diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of aspirin, indomethacin and ibuprofen: synthesis, biological evaluation and nitric oxide release studies.	University of Alberta
19136259	14	Synthesis of 1-(methanesulfonyl- and aminosulfonylphenyl)acetylenes that possess a 2-(N-difluoromethyl-1,2-dihydropyridin-2-one) pharmacophore: evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.	University of Alberta
19084295	5	Synthesis and biological evaluation of 4,5-diphenyloxazolone derivatives on route towards selective COX-2 inhibitors.	Gazi University
18945614	8	Synthesis of celecoxib analogs that possess a N-hydroxypyrid-2(1H)one 5-lipoxygenase pharmacophore: biological evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.	University of Alberta
18930406	12	Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 5-(4-hydroxymethylphenyl)-1-(4-aminosulfonylphenyl)-3-trifluoromethyl-1H-pyrazole and its methanesulfonyl analog: synthesis, biological evaluation and nitric oxide release studies.	University of Alberta
18835505	15	Design, synthesis and evaluation of tetrahydropyran based COX-1/-2 inhibitors.	Guru Nanak Dev University
16792405	11	Nitrogen-containing phorbol esters from Croton ciliatoglandulifer and their effects on cyclooxygenases-1 and -2.	Centro De Investigaciones QuíMicas De La Universidad AutóNoma Del Estado De Morelos
16252923	4	Anti-inflammatory acylphloroglucinol derivatives from Hops (Humulus lupulus).	Fr. 8.2 Pharmakognosie Und Analytische Phytochemie Der UniversitäT Des Saarlandes
15679320	12	Lanostane triterpenoids and triterpene glycosides from the fruit body of Fomitopsis pinicola and their inhibitory activity against COX-1 and COX-2.	Tokushima Bunri University
10757731	3	Two new prenylated 3-benzoxepin derivatives as cyclooxygenase inhibitors from Perilla frutescens var. acuta.	Columbia University
18226898	12	Design and synthesis of 1,3-diarylurea derivatives as selective cyclooxygenase (COX-2) inhibitors.	Shaheed Beheshti University of Medical Sciences
18072726	4	New celecoxib derivatives as anti-inflammatory agents.	Gedeon Richter
18061444	7	1-Toluene-sulfonyl-3-[(3'-hydroxy-5'-substituted)-gamma-butyrolactone]-indoles: synthesis, COX-2 inhibition and anti-cancer activities.	Guru Nanak Dev University
17937989	6	Synthesis and biological evaluation of 2-trifluoromethyl/sulfonamido-5,6-diaryl substituted imidazo[2,1-b]-1,3,4-thiadiazoles: a novel class of cyclooxygenase-2 inhibitors.	The University of The West Indies
17764958	18	Novel (E)-2-(aryl)-3-(4-methanesulfonylphenyl)acrylic ester prodrugs possessing a diazen-1-ium-1,2-diolate moiety: design, synthesis, cyclooxygenase inhibition, and nitric oxide release studies.	University of Alberta
17604631	22	'Bridged' stilbene derivatives as selective cyclooxygenase-1 inhibitors.	University of Vienna
17509888	12	O2-acetoxymethyl-protected diazeniumdiolate-based NSAIDs (NONO-NSAIDs): synthesis, nitric oxide release, and biological evaluation studies.	National Cancer Institute At Frederick
17258905	22	Design, synthesis, and biological evaluation of substituted 2-alkylthio-1,5-diarylimidazoles as selective COX-2 inhibitors.	Tehran University of Medical Sciences
17079150	14	Analgesic agents without gastric damage: design and synthesis of structurally simple benzenesulfonanilide-type cyclooxygenase-1-selective inhibitors.	Okayama University Graduate School of Medicine
17067801	14	Synthesis and biological evaluation of methanesulfonamide analogues of rofecoxib: Replacement of methanesulfonyl by methanesulfonamido decreases cyclooxygenase-2 selectivity.	University of Alberta Edmonton
16806914	6	Design and synthesis of new water-soluble tetrazolide derivatives of celecoxib and rofecoxib as selective cyclooxygenase-2 (COX-2) inhibitors.	Tehran University of Medical Sciences
15943479	18	Novel nonsteroidal antiinflammatory drugs possessing a nitric oxide donor diazen-1-ium-1,2-diolate moiety: design, synthesis, biological evaluation, and nitric oxide release studies.	University of Alberta
15887968	13	Stereoselective binding of indomethacin ethanolamide derivatives to cyclooxygenase-1.	Vanderbilt University
15603969	40	Design and synthesis of (E)-1,1,2-triarylethenes: novel inhibitors of the cyclooxygenase-2 (COX-2) isozyme.	University of Alberta
15537365	20	A new class of acyclic 2-alkyl-1,1,2-triaryl (Z)-olefins as selective cyclooxygenase-2 inhibitors.	University of Alberta
15369391	3	Novel cyclooxygenase-1 inhibitors discovered using affinity fingerprints.	Telik
15341950	14	A new class of acyclic 2-alkyl-1,2-diaryl (E)-olefins as selective cyclooxygenase-2 (COX-2) inhibitors.	University of Alberta
15267236	72	Design, synthesis, and structure-activity relationship studies of 3,4,6-triphenylpyran-2-ones as selective cyclooxygenase-2 inhibitors.	University of Alberta
15050636	14	Sulfonamido, azidosulfonyl and N-acetylsulfonamido analogues of rofecoxib: 4-[4-(N-acetylsulfonamido)phenyl]-3-(4-methanesulfonylphenyl)-2(5H)furanone is a potent and selective cyclooxygenase-2 inhibitor.	University of Alberta
15050635	18	Design of acyclic triaryl olefins: a new class of potent and selective cyclooxygenase-2 (COX-2) inhibitors.	University of Alberta
15026050	31	Methanesulfonamide group at position-4 of the C-5-phenyl ring of 1,5-diarylpyrazole affords a potent class of cyclooxygenase-2 (COX-2) inhibitors.	Discovery Research-Dr. Reddy'S Laboratories
15013005	4	Synthesis and evaluation of S-4-(3-thienyl)phenyl-alpha-methylacetic acid.	National Institute of Pharmaceutical Education and Research
14741265	15	Manipulation of kinetic profiles in 2-aryl propionic acid cyclooxygenase inhibitors.	Drexel University College of Medicine
14698190	44	Polar substitutions in the benzenesulfonamide ring of celecoxib afford a potent 1,5-diarylpyrazole class of COX-2 inhibitors.	Discovery Research-Dr. Reddy'S Laboratories
14698178	8	1,2-Diaryl-1-ethanone and pyrazolo [4,3-c] quinoline-4-one as novel selective cyclooxygenase-2 inhibitors.	Dr. Reddy'S Laboratories
12954051	10	Synthesis and cyclooxygenase-2 inhibiting property of 1,5-diarylpyrazoles with substituted benzenesulfonamide moiety as pharmacophore: Preparation of sodium salt for injectable formulation.	Dr. Reddy'S Laboratories
12798335	22	6-Alkyl, alkoxy, or alkylthio-substituted 3-(4-methanesulfonylphenyl)-4-phenylpyran-2-ones: a novel class of diarylheterocyclic selective cyclooxygenase-2 inhibitors.	University of Alberta
12127515	29	SAR of 2,6-diamino-3,5-difluoropyridinyl substituted heterocycles as novel p38MAP kinase inhibitors.	Novartis Pharma
11965379	94	Enantiospecific, selective cyclooxygenase-2 inhibitors.	Vanderbilt University School of Medicine
11909713	42	Thalidomide and its analogues as cyclooxygenase inhibitors.	The University of Tokyo
11844663	54	Amide derivatives of meclofenamic acid as selective cyclooxygenase-2 inhibitors.	Vanderbilt University School of Medicine
32127262	40	Novel class of benzimidazole-thiazole hybrids: The privileged scaffolds of potent anti-inflammatory activity with dual inhibition of cyclooxygenase and 15-lipoxygenase enzymes.	Assiut University
32503692	2	Synthesis of novel 3,5,6-trisubstituted 2-pyridone derivatives and evaluation for their anti-inflammatory activity.	Universidade Estadual De Maring£
32278513	8	Screening of chalcone analogs with anti-depressant, anti-inflammatory, analgesic, and COX-2-inhibiting effects.	China-Japan Union Hospital of Jilin University
31843462	47	Modification of the lead molecule: Tryptophan and piperidine appended triazines reversing inflammation and hyeperalgesia in rats.	Guru Nanak Dev University
27567369	20	Structure-activity relationship of novel series of 1,5-disubstituted tetrazoles as cyclooxygenase-2 inhibitors: Design, synthesis, bioassay screening and molecular docking studies.	American University of Madaba
10956194	152	Ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors.	Vanderbilt University School of Medicine
27658794	5	Synthesis of phenylpiperazine derivatives of 1,4-benzodioxan as selective COX-2 inhibitors and anti-inflammatory agents.	Shandong University of Technology
27486833	37	Discovery of (R)-2-(6-Methoxynaphthalen-2-yl)butanoic Acid as a Potent and Selective Aldo-keto Reductase 1C3 Inhibitor.	University of Pennsylvania
10866395	33	SAR of 4-hydroxypiperidine and hydroxyalkyl substituted heterocycles as novel p38 map kinase inhibitors.	Novartis Pharma
26791385	12	Design and Development of Microsomal Prostaglandin E2 Synthase-1 Inhibitors: Challenges and Future Directions.	University Jena
30590258	35	Translational impact of novel widely pharmacological characterized mofezolac-derived COX-1 inhibitors combined with bortezomib on human multiple myeloma cell lines viability.	University of Bari "Aldo Moro
31774676	140	Structure-Activity Relationships of Pentacyclic Triterpenoids as Inhibitors of Cyclooxygenase and Lipoxygenase Enzymes.	Osaka University
31301566	16	Design of balanced COX inhibitors based on anti-inflammatory and/or COX-2 inhibitory ascidian metabolites.	Pusan National University
31255927	34	Human disorders associated with inflammation and the evolving role of natural products to overcome.	University of Delhi
30818268	50	Shooting three inflammatory targets with a single bullet: Novel multi-targeting anti-inflammatory glitazones.	Alexandria University
10230624	110	N-hydroxyurea and hydroxamic acid inhibitors of cyclooxygenase and 5-lipoxygenase.	The R. W. Johnson Pharmaceutical Research Institute
10230611	48	Terphenyl cyclooxygenase-2 (COX-2) inhibitors: optimization of the central ring and o-biphenyl analogs.	Dupont Pharmaceuticals
10091674	36	Structure-based design of COX-2 selectivity into flurbiprofen.	Merck Frosst Canada
31299586	12	Design, synthesis, biological evaluation and docking study of novel indole-2-amide as anti-inflammatory agents with dual inhibition of COX and 5-LOX.	Anhui University of Chinese Medicine
31244108	22	Engineered Substrate for Cyclooxygenase-2: A Pentapeptide Isoconformational to Arachidonic Acid for Managing Inflammation.	TBA
9822550	98	Covalent modification of cyclooxygenase-2 (COX-2) by 2-acetoxyphenyl alkyl sulfides, a new class of selective COX-2 inactivators.	Center In Molecular Toxicology and The Vanderbilt Cancer Center
30995567	5	Synthetic approaches and pharmaceutical applications of chloro-containing molecules for drug discovery: A critical review.	Wuhan University of Technology
30928709	30	Novel benzenesulfonamide and 1,2-benzisothiazol-3(2H)-one-1,1-dioxide derivatives as potential selective COX-2 inhibitors.	Al-Azhar University
31268709	17	Prenylated Stilbenoids Affect Inflammation by Inhibiting the NF-?B/AP-1 Signaling Pathway and Cyclooxygenases and Lipoxygenase.	Czech Academy of Sciences
30996776	12	Bioisosteres of Indomethacin as Inhibitors of Aldo-Keto Reductase 1C3.	University of Turin
30771604	75	Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase.	Alexandria University
9484493	11	Design, synthesis, and biological evaluation of conformationally constrained aci-reductone mimics of arachidonic acid.	Oxis International
31401465	52	Multi-target-directed-ligands acting as enzyme inhibitors and receptor ligands.	Julius Maximilian University of W£Rzburg
31539778	58	New oxadiazoles with selective-COX-2 and EGFR dual inhibitory activity: Design, synthesis, cytotoxicity evaluation and in silico studies.	Cairo University
26487917	61	Synthesis and Evaluation of Novel Erlotinib-NSAID Conjugates as More Comprehensive Anticancer Agents.	Guangzhou Institutes of Biomedicine and Health
26546221	34	Synthesis, cyclooxygenase inhibition, anti-inflammatory evaluation and ulcerogenic liability of novel triarylpyrazoline derivatives as selective COX-2 inhibitors.	Beni-Suef University
24607877	20	Celecoxib analogs bearing benzofuran moiety as cyclooxygenase-2 inhibitors: design, synthesis and evaluation as potential anti-inflammatory agents.	Cairo University
24531199	16	Selective COX-1 inhibition as a target of theranostic novel diarylisoxazoles.	University of Bari "A. Moro
24361187	12	Synthesis, docking simulation, biological evaluations and 3D-QSAR study of 5-Aryl-6-(4-methylsulfonyl)-3-(metylthio)-1,2,4-triazine as selective cyclooxygenase-2 inhibitors.	Mazandaran University of Medical Sciences
24332492	16	Rationally designed hybrid molecules with appreciable COX-2 inhibitory and anti-nociceptive activities.	Guru Nanak Dev University
23769654	24	Synthesis of novel celecoxib analogues by bioisosteric replacement of sulfonamide as potent anti-inflammatory agents and cyclooxygenase inhibitors.	Kurukshetra University
23914900	8	Rotenoids from Boerhaavia diffusa as potential anti-inflammatory agents.	National Institute of Pharmaceutical Education and Research (NIPER)
23693150	4	Synthesis of some novel chalcones, flavanones and flavones and evaluation of their anti-inflammatory activity.	Jamia Hamdard (Hamdard University)
23706267	32	1,4-Diaryl-substituted triazoles as cyclooxygenase-2 inhibitors: Synthesis, biological evaluation and molecular modeling studies.	University of Alberta
23687559	9	The 2'-Trifluoromethyl Analogue of Indomethacin Is a Potent and Selective COX-2 Inhibitor.	Vanderbilt University
23517721	8	Novel dual cyclooxygenase and lipoxygenase inhibitors targeting hyaluronan-CD44v6 pathway and inducing cytotoxicity in colon cancer cells.	Medical University of South Carolina
23528298	64	Molecular design, synthesis and biological evaluation of cyclic imides bearing benzenesulfonamide fragment as potential COX-2 inhibitors. Part 2.	King Saud University
19303782	40	Phenolic compounds with radical scavenging and cyclooxygenase-2 (COX-2) inhibitory activities from Dioscorea opposita.	Seoul National University
30293795	6	Synthesis, in vitro and in vivo biological evaluation, COX-1/2 inhibition and molecular docking study of indole-N-acylhydrazone derivatives.	Universidade Federal De Pernambuco (Ufpe)
28322565	19	Anti-inflammatory Activity of Natural Geranylated Flavonoids: Cyclooxygenase and Lipoxygenase Inhibitory Properties and Proteomic Analysis.	The Czech Academy of Sciences
30216848	30	Structural alterations based on naproxen scaffold: Synthesis, evaluation of antitumor activity and COX-2 inhibition, and molecular docking.	Mansoura University
29289887	71	Novel click modifiable thioquinazolinones as anti-inflammatory agents: Design, synthesis, biological evaluation and docking study.	Alexandria University
29133047	11	Discovery of new potent molecular entities able to inhibit mPGES-1.	University of Salerno
29980364	28	Synthesis and biological properties of aryl methyl sulfones.	Universitat De Barcelona
29602039	32	Potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the benzoisoxazole moiety: application of a bioisosteric scaffold hopping approach to flufenamic acid.	University of Torino
29426771	17	Design, synthesis, anti-inflammatory activity and molecular docking of potential novel antipyrine and pyrazolone analogs as cyclooxygenase enzyme (COX) inhibitors.	National Research Centre
29373271	36	Synthesis, biological evaluation and docking study of a new series of di-substituted benzoxazole derivatives as selective COX-2 inhibitors and anti-inflammatory agents.	Delhi Institute of Pharmaceutical Sciences and Research (Dipsar)
29191502	14	Synthesis, in vitro and in silico evaluation of novel trans-stilbene analogues as potential COX-2 inhibitors.	Poznan University of Medical Sciences
29329790	19	Plant-derived mPGES-1 inhibitors or suppressors: A new emerging trend in the search for small molecules to combat inflammation.	Abdul Wali Khan University Mardan
30095904	49	Tailoring the Substitution Pattern on 1,3,5-Triazine for Targeting Cyclooxygenase-2: Discovery and Structure-Activity Relationship of Triazine-4-Aminophenylmorpholin-3-one Hybrids that Reverse Algesia and Inflammation in Swiss Albino Mice.	TBA
28885836	12	Lipid Peroxidation and Cyclooxygenase Enzyme Inhibitory Compounds from Prangos haussknechtii.	Michigan State University
28881288	30	Hydroxytriazole derivatives as potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors discovered by bioisosteric scaffold hopping approach.	University of Torino
28710965	4	Structural basis for selective inhibition of Cyclooxygenase-1 (COX-1) by diarylisoxazoles mofezolac and 3-(5-chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6).	Thomas Jefferson University
28916158	28	Pyrrolizines: Design, synthesis, anticancer evaluation and investigation of the potential mechanism of action.	Umm Al-Qura University
28844389	30	Synthesis and biological evaluations of new nitric oxide-anti-inflammatory drug hybrids.	Beni-Suef University
28669741	9	Design, synthesis, and biological evaluation of some novel indolizine derivatives as dual cyclooxygenase and lipoxygenase inhibitor for anti-inflammatory activity.	Banaras Hindu University
28610982	6	Synthesis, potential anti-inflammatory and analgesic activities study of (S)-N-substituted-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxamides.	Zhejiang Ocean University Engineering Technology Research Center of Marine Biomedical Products
21774747	6	Biotransformation of dehydroepiandrosterone with Macrophomina phaseolina and ß-glucuronidase inhibitory activity of transformed products.	University of Karachi
21699374	15	Effects of dopaminergic compounds on carbonic anhydrase isozymes I, II, and VI.	Agri Ibrahim Cecen University
26833890	18	Synthesis, Biological Evaluation, and Molecular Docking of 8-imino-2-oxo-2H,8H-pyrano[2,3-f]chromene Analogs: New Dual AChE Inhibitors as Potential Drugs for the Treatment of Alzheimer's Disease.	Yogi Vemana University
19374401	103	Discovery of inducible nitric oxide synthase (iNOS) inhibitor development candidate KD7332, part 1: Identification of a novel, potent, and selective series of quinolinone iNOS dimerization inhibitors that are orally active in rodent pain models.	Kalypsys