305 articles for thisTarget

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The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
28613859	43	Donepezil-Based Central Acetylcholinesterase Inhibitors by Means of a"Bio-Oxidizable" Prodrug Strategy: Design, Synthesis, and in Vitro Biological Evaluation.	Vfp Therapies
28279845	54	Design, synthesis and evaluation of novel ferulic acid-O-alkylamine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.	Nanyang Normal University
27744187	42	Design, synthesis and biological evaluation of bambuterol analogues as novel inhibitors of butyrylcholinesterase.	South China University of Technology
27936444	93	Amino derivatives of platanic acid act as selective and potent inhibitors of butyrylcholinesterase.	Martin-Luther-University Halle-Wittenberg
27918993	29	Tetrahydropyranodiquinolin-8-amines as new, non hepatotoxic, antioxidant, and acetylcholinesterase inhibitors for Alzheimer's disease therapy.	University of Sfax
28189420	28	3,4-Dihydroquinazoline derivatives inhibit the activities of cholinesterase enzymes.	Kyung Hee University
28126439	27	Design, synthesis and evaluation of some N-methylenebenzenamine derivatives as selective acetylcholinesterase (AChE) inhibitor and antioxidant to enhance learning and memory.	Indian Institute of Technology (Banaras Hindu University)
28089589	78	Synthesis, anticholinesterase activity and molecular modeling study of novel carbamate-substituted thymol/carvacrol derivatives.	Bezmialem Vakif University
27721157	32	Design, synthesis, in-silico and biological evaluation of novel donepezil derivatives as multi-target-directed ligands for the treatment of Alzheimer's disease.	University of Delhi
27721153	18	Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation.	Jagiellonian University Medical College
27688184	29	New azepino[4,3-b]indole derivatives as nanomolar selective inhibitors of human butyrylcholinesterase showing protective effects against NMDA-induced neurotoxicity.	University of Bari&Quot;A. Moro&Quot
27689726	89	Repurposing N,N'-bis-(arylamidino)-1,4-piperazinedicarboxamidines: An unexpected class of potent inhibitors of cholinesterases.	Martin-Luther-University Halle-Wittenberg
27592396	40	New piperidine-hydrazone derivatives: Synthesis, biological evaluations and molecular docking studies as AChE and BChE inhibitors.	Gaziantep University
27560283	58	Novel multi-target-directed ligands for Alzheimer's disease: Combining cholinesterase inhibitors and 5-HT	Jagiellonian University Collegium Medicum
27484514	107	Rational modification of donepezil as multifunctional acetylcholinesterase inhibitors for the treatment of Alzheimer's disease.	China Pharmaceutical University
27376495	16	Avarol derivatives as competitive AChE inhibitors, non hepatotoxic and neuroprotective agents for Alzheimer's disease.	Istituto Di Chimica Biomolecolare (Icb)
27343850	26	Design, synthesis and evaluation of 4-dimethylamine flavonoid derivatives as potential multifunctional anti-Alzheimer agents.	Henan University
27769620	59	Synthesis and biological evaluation of ranitidine analogs as multiple-target-directed cognitive enhancers for the treatment of Alzheimer's disease.	University of South Carolina
27214510	33	Synthesis and anticholinesterase activity of coumarin-3-carboxamides bearing tryptamine moiety.	Islamic Azad University
27227482	30	Synthesis and screening of triazolopyrimidine scaffold as multi-functional agents for Alzheimer's disease therapies.	Jamia Millia Islamia (Central University)
27096334	14	Alkaloids from Hippeastrum argentinum and Their Cholinesterase-Inhibitory Activities: An in Vitro and in Silico Study.	Universidad Nacional De San Juan
27492195	14	Cholinesterase inhibitory activity of isoquinoline alkaloids from three Cryptocarya species (Lauraceae).	University of Malaya
27460699	76	Synthesis and evaluation of multi-target-directed ligands for the treatment of Alzheimer's disease based on the fusion of donepezil and melatonin.	China Pharmaceutical University
27353888	30	Design, synthesis and evaluation of novel indandione derivatives as multifunctional agents with cholinesterase inhibition, anti-ß-amyloid aggregation, antioxidant and neuroprotection properties against Alzheimer's disease.	University of Delhi
27236720	18	Natural cholinesterase inhibitors from Myristica cinnamomea King.	University of Malaya
27190595	70	Design, Synthesis, and Evaluation of Donepezil-Like Compounds as AChE and BACE-1 Inhibitors.	Universit£
27328658	36	2-Benzoyl-6-benzylidenecyclohexanone analogs as potent dual inhibitors of acetylcholinesterase and butyrylcholinesterase.	Universiti Putra Malaysia
27061983	48	Design, synthesis and evaluation of novel tacrine-multialkoxybenzene hybrids as multi-targeted compounds against Alzheimer's disease.	Guangzhou Medical University
27017111	33	Design, synthesis and bioactivity of novel phthalimide derivatives as acetylcholinesterase inhibitors.	Chinese Academy of Agricultural Sciences
26995529	14	2-Phenylbenzofuran derivatives as butyrylcholinesterase inhibitors: Synthesis, biological activity and molecular modeling.	University of Cagliari
27083471	46	Biological evaluation of synthetica,ß-unsaturated carbonyl based cyclohexanone derivatives as neuroprotective novel inhibitors of acetylcholinesterase, butyrylcholinesterase and amyloid-ß aggregation.	Wuhan University of Technology
26886849	72	Discovery of Highly Selective and Nanomolar Carbamate-Based Butyrylcholinesterase Inhibitors by Rational Investigation into Their Inhibition Mode.	Universit£T W£Rzburg
26383128	121	Converting maslinic acid into an effective inhibitor of acylcholinesterases.	Martin-Luther-Universit£T Halle-Wittenberg
26947959	35	Synthesis, structural characterization, docking, lipophilicity and cytotoxicity of 1-[(1R)-1-(6-fluoro-1,3-benzothiazol-2-yl)ethyl]-3-alkyl carbamates, novel acetylcholinesterase and butyrylcholinesterase pseudo-irreversible inhibitors.	University of Pardubice
26917219	63	Design, synthesis and biological evaluation of novel donepezil-coumarin hybrids as multi-target agents for the treatment of Alzheimer's disease.	China Pharmaceutical University
26752094	39	Design, synthesis and evaluation of novel 7-aminoalkyl-substituted flavonoid derivatives with improved cholinesterase inhibitory activities.	Henan University
26783181	24	Design and discovery of Novel Thiazole acetamide derivatives as anticholinesterase agent for possible role in the management of Alzheimer's.	Linyi People'S Hospital
26735910	23	Cardanol-derived AChE inhibitors: Towards the development of dual binding derivatives for Alzheimer's disease.	University of Bras£Lia
26514744	46	Synthesis of donepezil-based multifunctional agents for the treatment of Alzheimer's disease.	Ataturk University
26454504	28	Design, synthesis, biological evaluation and docking study of 4-isochromanone hybrids bearing N-benzyl pyridinium moiety as dual binding site acetylcholinesterase inhibitors.	China Pharmaceutical University
26244990	78	Potential of aryl-urea-benzofuranylthiazoles hybrids as multitasking agents in Alzheimer's disease.	Bezmialem Vakif University
26337018	44	Multifunctional novel Diallyl disulfide (DADS) derivatives withß-amyloid-reducing, cholinergic, antioxidant and metal chelating properties for the treatment of Alzheimer's disease.	University of Delhi
26242241	29	Synthesis, biological evaluation and molecular modeling of new tetrahydroacridine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.	Jagiellonian University Medical College
26278660	90	Evaluation of Homobivalent Carbolines as Designed Multiple Ligands for the Treatment of Neurodegenerative Disorders.	University of Jena
26212777	22	Discovery of new acetylcholinesterase inhibitors with small core structures through shape-based virtual screening.	Nanjing University of Chinese Medicine
25282654	56	Design, synthesis and evaluation of novel tacrine-(ß-carboline) hybrids as multifunctional agents for the treatment of Alzheimer's disease.	China Pharmaceutical University
25980913	9	Allobetulin derived seco-oleananedicarboxylates act as inhibitors of acetylcholinesterase.	Martin-Luther-Universit£T Halle-Wittenberg
26107513	172	Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases.	Universit£
25969170	38	Design, synthesis and anticholinesterase activity of novel benzylidenechroman-4-ones bearing cyclic amine side chain.	Tehran University of Medicinal Sciences
25812965	80	Multi-target tacrine-coumarin hybrids: cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease.	China Pharmaceutical University
25793650	47	Novel multitarget-directed ligands (MTDLs) with acetylcholinesterase (AChE) inhibitory and serotonergic subtype 4 receptor (5-HT4R) agonist activities as potential agents against Alzheimer's disease: the design of donecopride.	Cermn
25768702	86	Blood-brain barrier permeable anticholinesterase aurones: synthesis, structure-activity relationship, and drug-like properties.	Universiti Sains Malaysia
25621991	62	Development of multifunctional, heterodimeric isoindoline-1,3-dione derivatives as cholinesterase andß-amyloid aggregation inhibitors with neuroprotective properties.	Jagiellonian University Medical College
25656088	32	Multifunctional tacrine-trolox hybrids for the treatment of Alzheimer's disease with cholinergic, antioxidant, neuroprotective and hepatoprotective properties.	China Pharmaceutical University
25636055	13	Potent acetylcholinesterase inhibitors: design, synthesis, biological evaluation, and docking study of acridone linked to 1,2,3-triazole derivatives.	Tehran University of Medical Sciences
25868744	51	Synthesis of new N-benzylpiperidine derivatives as cholinesterase inhibitors withß-amyloid anti-aggregation properties and beneficial effects on memory in vivo.	Jagiellonian University
25724825	27	Design, synthesis and evaluation of novel 5,6,7-trimethoxyflavone-6-chlorotacrine hybrids as potential multifunctional agents for the treatment of Alzheimer's disease.	Wenzhou Medical University
25707322	47	Isoindoline-1,3-dione derivatives targeting cholinesterases: design, synthesis and biological evaluation of potential anti-Alzheimer's agents.	Jagiellonian University Medical College
25624107	74	Synthesis, biological evaluation and molecular docking study of novel piperidine and piperazine derivatives as multi-targeted agents to treat Alzheimer's disease.	University of Delhi
25597007	14	Synthesis and pharmacological evaluation of multifunctional tacrine derivatives against several disease pathways of AD.	Universit£
25047936	183	Amine substitution of quinazolinones leads to selective nanomolar AChE inhibitors with 'inverted' binding mode.	Universit£T Regensburg
25036795	45	Indolinone-based acetylcholinesterase inhibitors: synthesis, biological activity and molecular modeling.	Yazd University
25017625	45	Synthesis and cholinesterase inhibition of cativic acid derivatives.	Universidad Nacional Del Sur
25462245	27	New tetracyclic tacrine analogs containing pyrano[2,3-c]pyrazole: efficient synthesis, biological assessment and docking simulation study.	Tehran University of Medical Sciences
24941128	41	Synthesis and anti-cholinesterase activity of new 7-hydroxycoumarin derivatives.	Tehran University of Medical Sciences
24853320	62	Amino derivatives of glycyrrhetinic acid as potential inhibitors of cholinesterases.	Martin-Luther-Universit£T Halle-Wittenberg
24835788	28	Preparation, anticholinesterase activity and molecular docking of new lupane derivatives.	Universidad Nacional Del Sur
24813882	41	Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease.	Okayama University
24794747	36	Novel aromatic-polyamine conjugates as cholinesterase inhibitors with notable selectivity toward butyrylcholinesterase.	Henan University
24858540	12	Dibenzo[1,4,5]thiadiazepine: a hardly-known heterocyclic system with neuroprotective properties of potential usefulness in the treatment of neurodegenerative diseases.	Instituto De Qu£Mica M£Dica
24836068	19	Structural modifications of 4-aryl-4-oxo-2-aminylbutanamides and their acetyl- and butyrylcholinesterase inhibitory activity. Investigation of AChE-ligand interactions by docking calculations and molecular dynamics simulations.	Ratka Resanovica1
24819955	36	Identification of a neuroprotective and selective butyrylcholinesterase inhibitor derived from the natural alkaloid evodiamine.	University of W£Rzburg
24731278	22	Synthesis and in vitro evaluation of anti-inflammatory activity of ester and amine derivatives of indoline in RAW 264.7 and peritoneal macrophages.	Bar-Ilan University
24726809	72	Design, synthesis and biological evaluation of benzylisoquinoline derivatives as multifunctional agents against Alzheimer's disease.	China Pharmaceutical University
24594354	46	Synthesis and discovery of highly functionalized mono- and bis-spiro-pyrrolidines as potent cholinesterase enzyme inhibitors.	Universiti Sains Malaysia
24681070	15	Novel structural hybrids of pyrazolobenzothiazines with benzimidazoles as cholinesterase inhibitors.	Government College Women University
24657052	42	Quinolone-benzylpiperidine derivatives as novel acetylcholinesterase inhibitor and antioxidant hybrids for Alzheimer disease.	Universit£
24594525	25	Design, synthesis and biological evaluation of D-ring opened galantamine analogs as multifunctional anti-Alzheimer agents.	Southeast University
24530494	42	Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease.	Laboratorio De Quimica Medica (Iqog, Csic)
24461561	24	Ionic liquid mediated synthesis of mono- and bis-spirooxindole-hexahydropyrrolidines as cholinesterase inhibitors and their molecular docking studies.	Universiti Sains Malaysia
24461494	28	Synthesis and biological evaluation of a new series of ebselen derivatives as glutathione peroxidase (GPx) mimics and cholinesterase inhibitors against Alzheimer's disease.	Sun Yat-Sen University
24378710	18	Cannabinoid agonists showing BuChE inhibition as potential therapeutic agents for Alzheimer's disease.	Instituto De Qu£Mica M£Dica (Csic)
24369842	62	Cholinesterase inhibitory activity versus aromatic core multiplicity: a facile green synthesis and molecular docking study of novel piperidone embedded thiazolopyrimidines.	Universiti Sains Malaysia
24220172	25	Novel tacrine-ebselen hybrids with improved cholinesterase inhibitory, hydrogen peroxide and peroxynitrite scavenging activity.	Sun Yat-Sen University
24148835	41	Design, synthesis and evaluation of novel 4-dimethylamine flavonoid derivatives as potential multi-functional anti-Alzheimer agents.	Henan University
24128814	38	Inhibition of cholinesterase and monoamine oxidase-B activity by Tacrine-Homoisoflavonoid hybrids.	Sun Yat-Sen University
24211638	28	Novel coumarin-3-carboxamides bearing N-benzylpiperidine moiety as potent acetylcholinesterase inhibitors.	Kerman University of Medical Sciences
24160297	37	Synthesis and evaluation of multi-target-directed ligands against Alzheimer's disease based on the fusion of donepezil and ebselen.	Sun Yat-Sen University
24148993	4	Acetylcholinesterase inhibitors as Alzheimer therapy: from nerve toxins to neuroprotection.	Punjabi University
24095756	48	Multifunctional tacrine-flavonoid hybrids with cholinergic,ß-amyloid-reducing, and metal chelating properties for the treatment of Alzheimer's disease.	China Pharmaceutical University
23988412	39	Design, synthesis, docking study and biological evaluation of some novel tetrahydrochromeno [3',4':5,6]pyrano[2,3-b]quinolin-6(7H)-one derivatives against acetyl- and butyrylcholinesterase.	Tehran University of Medical Sciences
23988409	32	Design, synthesis, biological evaluation and docking study of 5-oxo-4,5-dihydropyrano[3,2-c]chromene derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors.	Tehran University of Medical Sciences
23932451	34	Synthesis and biological evaluation of berberine-thiophenyl hybrids as multi-functional agents: Inhibition of acetylcholinesterase, butyrylcholinesterase, and Aß aggregation and antioxidant activity.	Sun Yat-Sen University
23871902	42	An expedient, ionic liquid mediated multi-component synthesis of novel piperidone grafted cholinesterase enzymes inhibitors and their molecular modeling study.	Universiti Sains Malaysia
23891231	42	Synthesis, biological activity and molecular modeling studies on 1H-benzimidazole derivatives as acetylcholinesterase inhibitors.	Ege University
23799643	5	Design, synthesis, and evaluation of multitarget-directed resveratrol derivatives for the treatment of Alzheimer's disease.	Sun Yat-Sen University
23685572	55	Design, synthesis and evaluation of novel tacrine-coumarin hybrids as multifunctional cholinesterase inhibitors against Alzheimer's disease.	China Pharmaceutical University
23644208	40	Synthesis and evaluation of 4-substituted coumarins as novel acetylcholinesterase inhibitors.	University of Zanjan
23511019	60	Design, synthesis and evaluation of flavonoid derivatives as potential multifunctional acetylcholinesterase inhibitors against Alzheimer's disease.	China Pharmaceutical University
23602518	50	Microwave assisted synthesis, cholinesterase enzymes inhibitory activities and molecular docking studies of new pyridopyrimidine derivatives.	Universiti Sains Malaysia
23639542	32	NO-donating tacrine derivatives as potential butyrylcholinesterase inhibitors with vasorelaxation activity.	China Pharmaceutical University
23570788	23	A facile chemo-, regio- and stereoselective synthesis and cholinesterase inhibitory activity of spirooxindole-pyrrolizine-piperidine hybrids.	Universiti Sains Malaysia
23541836	24	Design, synthesis and evaluation of tacrine-flurbiprofen-nitrate trihybrids as novel anti-Alzheimer's disease agents.	China Pharmaceutical University
23501115	62	Synthesis and evaluation of 7,8-dehydrorutaecarpine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.	Sun Yat-Sen University
23462716	49	Synthesis and in vitro evaluation of new derivatives of 2-substituted-6-fluorobenzo[d]thiazoles as cholinesterase inhibitors.	University of Pardubice
23454517	56	A novel series of tacrine-selegiline hybrids with cholinesterase and monoamine oxidase inhibition activities for the treatment of Alzheimer's disease.	Sun Yat-Sen University
23454132	68	Synthesis and discovery of novel piperidone-grafted mono- and bis-spirooxindole-hexahydropyrrolizines as potent cholinesterase inhibitors.	Universiti Sains Malaysia
23376249	46	Synthesis and biological evaluation of 1,3,4-thiadiazole analogues as novel AChE and BuChE inhibitors.	University of Life Sciences
23273219	17	Synthesis, molecular modeling and evaluation of novel N'-2-(4-benzylpiperidin-/piperazin-1-yl)acylhydrazone derivatives as dual inhibitors for cholinesterases and Aß aggregation.	Baskent University
23199476	36	Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase.	Universit£
20926161	21	Novel alkyl- and arylcarbamate derivatives with N-benzylpiperidine and N-benzylpiperazine moieties as cholinesterases inhibitors.	Jagiellonian University Medical College
20158205	34	Hybrid molecules from xanomeline and tacrine: enhanced tacrine actions on cholinesterases and muscarinic M1 receptors.	China Pharmaceutical University
23140986	38	Novel coumarin derivatives bearing N-benzyl pyridinium moiety: potent and dual binding site acetylcholinesterase inhibitors.	University College of Science
22624880	16	Tacrine-silibinin codrug shows neuro- and hepatoprotective effects in vitro and pro-cognitive and hepatoprotective effects in vivo.	Universit£T Regensburg
22512543	72	Tacrine-ferulic acid-nitric oxide (NO) donor trihybrids as potent, multifunctional acetyl- and butyrylcholinesterase inhibitors.	China Pharmaceutical University
23062825	37	Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.	Abo Akademi University
23000296	40	Novel multipotent phenylthiazole-tacrine hybrids for the inhibition of cholinesterase activity,ß-amyloid aggregation and Ca²¿ overload.	Huazhong University of Science and Technology
24900407	63	Neuroprotective Tri- and Tetracyclic BChE Inhibitors Releasing Reversible Inhibitors upon Carbamate Transfer.	TBA
23108363	6	Design, synthesis and biological evaluation of benzo[e][1,2,4]triazin-7(1H)-one and [1,2,4]-triazino[5,6,1-jk]carbazol-6-one derivatives as dual inhibitors of beta-amyloid aggregation and acetyl/butyryl cholinesterase.	Universit£
22981331	14	Design, synthesis and pharmacological evaluation of novel tacrine-caffeic acid hybrids as multi-targeted compounds against Alzheimer's disease.	Sun Yat-Sen University
22944335	43	O-Hydroxyl- or o-amino benzylamine-tacrine hybrids: multifunctional biometals chelators, antioxidants, and inhibitors of cholinesterase activity and amyloid-ß aggregation.	Sun Yat-Sen University
23078965	19	Pyridonepezils, new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease: synthesis, biological assessment, and molecular modeling.	Instituto De Qu£Mica Org£Nica General (Csic)
22704921	34	Development and evaluation of multifunctional agents for potential treatment of Alzheimer's disease: application to a pyrimidine-2,4-diamine template.	University of Waterloo
22633691	42	Design, synthesis, and evaluation of indanone derivatives as acetylcholinesterase inhibitors and metal-chelating agents.	Sun Yat-Sen University
22420827	14	Multifunctional mercapto-tacrine derivatives for treatment of age-related neurodegenerative diseases.	Huazhong University of Science and Technology
21715067	15	Synthesis and pharmacological assessment of diversely substituted pyrazolo[3,4-b]quinoline, and benzo[b]pyrazolo[4,3-g][1,8]naphthyridine derivatives.	University of Lisbon
22472046	40	Inhibition of cholinesterase activity and amyloid aggregation by berberine-phenyl-benzoheterocyclic and tacrine-phenyl-benzoheterocyclic hybrids.	Sun Yat-Sen University
22243648	112	New tacrine-4-oxo-4H-chromene hybrids as multifunctional agents for the treatment of Alzheimer's disease, with cholinergic, antioxidant, andß-amyloid-reducing properties.	Instituto De Qu£Mica M£Dica
22444876	34	Design, synthesis and evaluation of isaindigotone derivatives as dual inhibitors for acetylcholinesterase and amyloid beta aggregation.	Sun Yat-Sen University
20575555	45	Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives.	Universidad Autonoma De Madrid
20350808	36	Bivalent 5,8,9,13b-tetrahydro-6H-isoquino[1,2-a]isoquinolines and -isoquinolinium salts: novel heterocyclic templates for butyrylcholinesterase inhibitors.	Friedrich-Schiller-Universit£T Jena
20176490	8	Acetylcholinesterase inhibitors from the toadstool Cortinarius infractus.	Institute of Plant Biochemistry
16989531	10	Taspine: bioactivity-guided isolation and molecular ligand-target insight of a potent acetylcholinesterase inhibitor from Magnolia x soulangiana.	Leopold-Franzens-Universit£T
18479118	114	Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.	Universit£
17574306	29	Synthesis and biological evaluation of helicid analogues as novel acetylcholinesterase inhibitors.	Sun Yat-Sen University
22341944	29	Novel oxoisoaporphine-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.	School of Chemistry & Chemical Engineering of Guangxi Normal University
21420206	38	N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease.	Instituto De Qu£Mica M£Dica
22023459	42	Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.	Universitat Aut£Noma De Barcelona
22001085	22	Synthesis and testing of trifluoromethyl-containing phosphonate-peptide conjugates as inhibitors of serine hydrolases.	Moscow State University
22019228	52	Synthesis, biological evaluation of 9-N-substituted berberine derivatives as multi-functional agents of antioxidant, inhibitors of acetylcholinesterase, butyrylcholinesterase and amyloid-ß aggregation.	Sun Yat-Sen University
22000936	33	Synthesis and biological assessment of diversely substituted furo[2,3-b]quinolin-4-amine and pyrrolo[2,3-b]quinolin-4-amine derivatives, as novel tacrine analogues.	University of Lisbon
21873056	50	Development of 2-substituted-N-(naphth-1-ylmethyl) and N-benzhydrylpyrimidin-4-amines as dual cholinesterase and Aß-aggregation inhibitors: Synthesis and biological evaluation.	University of Waterloo
21871694	28	Hybrids of oxoisoaporphine-tacrine congeners: novel acetylcholinesterase and acetylcholinesterase-inducedß-amyloid aggregation inhibitors.	Guangxi Normal University
21546135	10	Mycobacterium tuberculosis and cholinesterase inhibitors from Voacanga globosa.	University of Santo Tomas
21459491	96	Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer's disease.	Universit£
21497959	28	Synthesis and evaluation of heterobivalent tacrine derivatives as potential multi-functional anti-Alzheimer agents.	Sun Yat-Sen University
21367493	32	Syntheses and characterization of novel oxoisoaporphine derivatives as dual inhibitors for cholinesterases and amyloid beta aggregation.	Sun Yat-Sen University
21411323	24	Synthesis, biological assessment and molecular modeling of 14-aryl-10,11,12,14-tetrahydro-9H-benzo[5,6]chromeno[2,3-b]quinolin-13-amines.	Universit£
21232964	50	Probing the mid-gorge of cholinesterases with spacer-modified bivalent quinazolinimines leads to highly potent and selective butyrylcholinesterase inhibitors.	Queen'S University Belfast
21111515	12	Synthesis, biological assessment and molecular modeling of new dihydroquinoline-3-carboxamides and dihydroquinoline-3-carbohydrazide derivatives as cholinesterase inhibitors, and Ca channel antagonists.	UniversitÉ
20964319	7	Citrusosides A-D and furanocoumarins with cholinesterase inhibitory activity from the fruit peels of Citrus hystrix.	Ramkhamhaeng University
21163662	39	Cholinergic and neuroprotective drugs for the treatment of Alzheimer and neuronal vascular diseases. II. Synthesis, biological assessment, and molecular modelling of new tacrine analogues from highly substituted 2-aminopyridine-3-carbonitriles.	Laboratorio De Radicales Libres Y Qu�Mica Computacional (Iqog, Csic)
20926162	14	Old phenothiazine and dibenzothiadiazepine derivatives for tomorrow's neuroprotective therapies against neurodegenerative diseases.	Instituto De Qu£Mica M£Dica
20545360	38	Novel tacrine-8-hydroxyquinoline hybrids as multifunctional agents for the treatment of Alzheimer's disease, with neuroprotective, cholinergic, antioxidant, and copper-complexing properties.	Instituto De Quimica Medica
20471843	60	Synthesis and biological evaluation of a new series of berberine derivatives as dual inhibitors of acetylcholinesterase and butyrylcholinesterase.	Sun Yat-Sen University
20472431	32	Design, synthesis and evaluation of 2,4-disubstituted pyrimidines as cholinesterase inhibitors.	University of Waterloo
20452769	74	Synthesis of 4-[(diethylamino)methyl]-phenol derivatives as novel cholinesterase inhibitors with selectivity towards butyrylcholinesterase.	Sun Yat-Sen University
20361801	100	Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents.	Friedrich-Schiller-Universitat Jena
20350807	7	Molecular modelling, synthesis and acetylcholinesterase inhibition of ethyl 5-amino-2-methyl-6,7,8,9-tetrahydrobenzo[b][1,8]naphthyridine-3-carboxylate.	Laboratorio De Radicales Libres Y QuÍMica Computacional (Iqog, Csic)
20079560	28	Synthesis and evaluation of novel rutaecarpine derivatives and related alkaloids derivatives as selective acetylcholinesterase inhibitors.	Sun Yat-Sen University
19856923	40	Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease.	Instituto De Quimica Medica (Csic)
20056426	38	Synthesis, biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitors.	Sun Yat-Sen University
20149667	17	Interaction of (benzylidene-hydrazono)-1,4-dihydropyridines with beta-amyloid, acetylcholine, and butyrylcholine esterases.	Ege University
20061157	45	4-Aryl-4-oxo-N-phenyl-2-aminylbutyramides as acetyl- and butyrylcholinesterase inhibitors. Preparation, anticholinesterase activity, docking study, and 3D structure-activity relationship based on molecular interaction fields.	Institute
19243862	36	Synthesis, biological evaluation and molecular modeling of oxoisoaporphine and oxoaporphine derivatives as new dual inhibitors of acetylcholinesterase/butyrylcholinesterase.	Sun Yat-Sen University
18585045	22	Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors.	Università
18524585	20	Design, synthesis and evaluation of isaindigotone derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors.	Sun Yat-Sen University
17624631	9	Chemiluminescent high-throughput microassay applied to imidazo[2,1-b]thiazole derivatives as potential acetylcholinesterase and butyrylcholinesterase inhibitors.	Università
17067156	11	Microbial transformation and butyrylcholinesterase inhibitory activity of (-)-caryophyllene oxide and its derivatives.	University of Karachi
16378379	3	Nostocarboline: isolation and synthesis of a new cholinesterase inhibitor from Nostoc 78-12A.	University of ZüRich
11421762	6	Steroidal alkaloids from the leaves of Sarcococca coriacea of Nepalese origin.	Tribhuvan University
32165042	24	Discovery of 9-phenylacridinediones as highly selective butyrylcholinesterase inhibitors through structure-based virtual screening.	University of The Western Cape
32008882	38	Design, synthesis and biological evaluation of novel carbamates as potential inhibitors of acetylcholinesterase and butyrylcholinesterase.	Jinan University
32787113	9	Discovery and Biological Evaluation of a Novel Highly Potent Selective Butyrylcholinsterase Inhibitor.	China Pharmaceutical University
32381396	12	Synthesis, biochemical evaluation, and molecular modeling of organophosphate-coumarin hybrids as potent and selective butyrylcholinesterase inhibitors.	California State University
32309949	50	Aromatic Esters of the Crinane Amaryllidaceae Alkaloid Ambelline as Selective Inhibitors of Butyrylcholinesterase.	University of Defence
32031378	17	Acetylene Group, Friend or Foe in Medicinal Chemistry.	St. John'S University
31864798	42	Propargylamine-derived multi-target directed ligands for Alzheimer's disease therapy.	Universidade De Lisboa
31744779	32	Synthesis, in vitro and in vivo biological evaluation of novel graveolinine derivatives as potential anti-Alzheimer agents.	Henan University
32150413	9	Bioactive Azepine-Indole Alkaloids from	Universidade Federal Do Rio Grande Do Sul-Ufrgs
31901382	10	Design, synthesis and anti-Alzheimer's disease activity study of xanthone derivatives based on multi-target strategy.	Tianjin University of Traditional Chinese Medicine
31882295	63	Synthesis and biological evaluation of 4-arylcoumarins as potential anti-Alzheimer's disease agents.	University of Jinan-Shandong Academy of Medical Sciences
27426301	58	Synthesis and evaluation of novel 1,2,3-triazole-based acetylcholinesterase inhibitors with neuroprotective activity.	University of Jinan
27253679	94	Benzylpiperidine-Linked Diarylthiazoles as Potential Anti-Alzheimer's Agents: Synthesis and Biological Evaluation.	The Maharaja Sayajirao University of Baroda
27405689	14	Discovery and Structure-Activity Relationships of a Highly Selective Butyrylcholinesterase Inhibitor by Structure-Based Virtual Screening.	The University of Queensland
27445168	140	Cholinesterase inhibitory activity of chlorophenoxy derivatives-Histamine H3 receptor ligands.	Jagiellonian University Medical College
27347731	206	Exploring Basic Tail Modifications of Coumarin-Based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-Soluble, Brain-Permeant Neuroprotective Multitarget Agents.	Universit£
31437780	73	Discovery of novel series of 2-substituted benzo[d]oxazol-5-amine derivatives as multi-target directed ligands for the treatment of Alzheimer's disease.	Indian Institute of Technology (Banaras Hindu University)
31415981	37	Discovery of ?-sultone-fused pyrazoles for treating Alzheimer's disease: Design, synthesis, biological evaluation and SAR studies.	Anhui Medical University
31255926	46	Sulfamates in drug design and discovery: Pre-clinical and clinical investigations.	University of Sharjah
31158754	47	Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease.	University of Bari Aldo Moro
31055149	22	A multifunctional therapeutic approach: Synthesis, biological evaluation, crystal structure and molecular docking of diversified 1H-pyrazolo[3,4-b]pyridine derivatives against Alzheimer's disease.	Jamia Millia Islamia (Central University)
31029943	13	Benzoic acid-derived nitrones: A new class of potential acetylcholinesterase inhibitors and neuroprotective agents.	University of Porto
30956012	32	Design, synthesis, evaluation and molecular modeling study of 4-N-phenylaminoquinolines for Alzheimer disease treatment.	Tianjin University of Technology
30952387	22	Dispiropyrrolidinyl-piperidone embedded indeno[1,2-b]quinoxaline heterocyclic hybrids: Synthesis, cholinesterase inhibitory activity and their molecular docking simulation.	King Saud University
31281020	39	Dual functional cholinesterase and PDE4D inhibitors for the treatment of Alzheimer's disease: Design, synthesis and evaluation of tacrine-pyrazolo[3,4-b]pyridine hybrids.	Sun Yat-Sen University
31176571	24	Naphthalene-triazolopyrimidine hybrid compounds as potential multifunctional anti-Alzheimer's agents.	Jamia Millia Islamia (Central University)
31300317	14	1,2,3-Triazole-containing hybrids as leads in medicinal chemistry: A recent overview.	Chinese Academy of Sciences
31812794	16	1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer's disease.	Jagiellonian University Medical College
31669851	38	Search for new multi-target compounds against Alzheimer's disease among histamine H	Jagiellonian University Medical College
31352246	67	Triazole derivatives as inhibitors of Alzheimer's disease: Current developments and structure-activity relationships.	Wuhan Institute of Technology
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31229875	33	Design, synthesis, in-silico and biological evaluation of novel chalcone-O-carbamate derivatives as multifunctional agents for the treatment of Alzheimer's disease.	Nanyang Normal University
31376562	122	Tacrine-O-protected phenolics heterodimers as multitarget-directed ligands against Alzheimer's disease: Selective subnanomolar BuChE inhibitors.	Universidad De Sevilla
30888810	48	Validation of Phosphodiesterase-10 as a Novel Target for Pulmonary Arterial Hypertension via Highly Selective and Subnanomolar Inhibitors.	Sun Yat-Sen University
31444085	85	The development of 2-acetylphenol-donepezil hybrids as multifunctional agents for the treatment of Alzheimer's disease.	Guizhou Medical University
31280020	33	Novel N-benzylpiperidine carboxamide derivatives as potential cholinesterase inhibitors for the treatment of Alzheimer's disease.	University of Pretoria
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31103902	41	Multi-target design strategies for the improved treatment of Alzheimer's disease.	China Pharmaceutical University
31378596	25	Microwave-Assisted Organic Synthesis, structure-activity relationship, kinetics and molecular docking studies of non-cytotoxic benzamide derivatives as selective butyrylcholinesterase inhibitors.	University of Karachi
30744931	170	Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018).	Csir-Central Drug Research Institute
31128990	38	Design, synthesis, and biological evaluation of novel 4-oxobenzo[d]1,2,3-triazin-benzylpyridinum derivatives as potent anti-Alzheimer agents.	University of Zanjan
31401465	52	Multi-target-directed-ligands acting as enzyme inhibitors and receptor ligands.	Julius Maximilian University of W£Rzburg
30366255	81	Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors.	Universit£
31581002	70	Development of chalcone-O-alkylamine derivatives as multifunctional agents against Alzheimer's disease.	Chinese Academy of Sciences
30578075	14	In silico, NMR and pharmacological evaluation of an hydroxyoxindole cholinesterase inhibitor.	Universidade De £Vora
26827140	83	Synthesis, molecular docking and biological evaluation of N,N-disubstituted 2-aminothiazolines as a new class of butyrylcholinesterase and carboxylesterase inhibitors.	Institute of Physiologically Active Compounds Russian Academy of Sciences
26795115	34	Ferulic acid-carbazole hybrid compounds: Combination of cholinesterase inhibition, antioxidant and neuroprotection as multifunctional anti-Alzheimer agents.	Southeast University
26588065	45	Synthesis, pharmacological assessment, molecular modeling and in silico studies of fused tricyclic coumarin derivatives as a new family of multifunctional anti-Alzheimer agents.	Yogi Vemana University
25059502	94	Cyclic acyl guanidines bearing carbamate moieties allow potent and dirigible cholinesterase inhibition of either acetyl- or butyrylcholinesterase.	Universit£T Regensburg
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30096650	102	Donepezil-butylated hydroxytoluene (BHT) hybrids as Anti-Alzheimer's disease agents with cholinergic, antioxidant, and neuroprotective properties.	China Pharmaceutical University
30243151	23	Donepezil-based multi-functional cholinesterase inhibitors for treatment of Alzheimer's disease.	China Pharmaceutical University
29541355	35	Dual GSK-3?/AChE Inhibitors as a New Strategy for Multitargeting Anti-Alzheimer's Disease Drug Discovery.	China Pharmaceutical University
30190181	45	Design, synthesis, and biological evaluation of selective and potent Carbazole-based butyrylcholinesterase inhibitors.	Tehran University of Medical Sciences
30104121	55	Synthesis, molecular docking, and biological activity of 2-vinyl chromones: Toward selective butyrylcholinesterase inhibitors for potential Alzheimer's disease therapeutics.	Institute of Physiologically Active Compounds Russian Academy of Sciences
30017317	18	Structure-based design, synthesis, and evaluation of structurally rigid donepezil analogues as dual AChE and BACE-1 inhibitors.	Mansoura University
29475581	39	Investigation of multi-target-directed ligands (MTDLs) with butyrylcholinesterase (BuChE) and indoleamine 2,3-dioxygenase 1 (IDO1) inhibition: The design, synthesis of miconazole analogues targeting Alzheimer's disease.	China Pharmaceutical University
29429576	9	In silico studies, synthesis and pharmacological evaluation to explore multi-targeted approach for imidazole analogues as potential cholinesterase inhibitors with neuroprotective role for Alzheimer's disease.	Prin. K. M. Kundnani College of Pharmacy
29524731	76	Development of Piperazinediones as dual inhibitor for treatment of Alzheimer's disease.	Banaras Hindu University
29466774	78	Synthesis and activity towards Alzheimer's disease in vitro: Tacrine, phenolic acid and ligustrazine hybrids.	Chinese Academy of Medical Sciences & Peking Union Medical College
28810188	28	Novel tacrine derivatives exhibiting improved acetylcholinesterase inhibition: Design, synthesis and biological evaluation.	Technology and Research University-Vfstru (Vignan's University)
28803044	45	New racemic annulated pyrazolo[1,2-b]phthalazines as tacrine-like AChE inhibitors with potential use in Alzheimer's disease.	Tehran University of Medical Sciences
28800459	68	Novel cinnamamide-dibenzylamine hybrids: Potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease.	China Pharmaceutical University
28797883	56	Design, synthesis and biological evaluation of novel coumarin-N-benzyl pyridinium hybrids as multi-target agents for the treatment of Alzheimer's disease.	Shanghai University of Traditional Chinese Medicine
28728108	61	New tacrine dimers with antioxidant linkers as dual drugs: Anti-Alzheimer's and antiproliferative agents.	Universidad De Sevilla
28688279	56	Synthesis of novel 5-(aroylhydrazinocarbonyl)escitalopram as cholinesterase inhibitors.	University of The Punjab
29857276	53	Novel tetrahydrocarbazole benzyl pyridine hybrids as potent and selective butryl cholinesterase inhibitors with neuroprotective and ?-secretase inhibition activities.	Tehran University of Medical Sciences
29763808	57	Design, synthesis and evaluation of novel multi-target-directed ligands for treatment of Alzheimer's disease based on coumarin and lipoic acid scaffolds.	Tehran University of Medical Sciences
29438888	12	Tricyclic pyrazolo[1,5-d][1,4]benzoxazepin-5(6H)-one scaffold derivatives: Synthesis and biological evaluation as selective BuChE inhibitors.	Anhui Medical University
29421570	28	Design, synthesis and pharmacological evaluation of N-benzyl-piperidinyl-aryl-acylhydrazone derivatives as donepezil hybrids: Discovery of novel multi-target anti-alzheimer prototype drug candidates.	Federal University of Alfenas
29353726	19	Tetrahydroacridine derivatives with dichloronicotinic acid moiety as attractive, multipotent agents for Alzheimer's disease treatment.	Medical University of Lodz
29324339	115	Novel donepezil-like N-benzylpyridinium salt derivatives as AChE inhibitors and their corresponding dihydropyridine "bio-oxidizable" prodrugs: Synthesis, biological evaluation and structure-activity relationship.	Vfp Therapies
29268129	14	Development of tacrine-bifendate conjugates with improved cholinesterase inhibitory and pro-cognitive efficacy and reduced hepatotoxicity.	Henan University
28734245	47	Azaphenothiazines - promising phenothiazine derivatives. An insight into nomenclature, synthesis, structure elucidation and biological properties.	The Medical University of Silesia
28505534	28	Discorhabdin alkaloids from Antarctic Latrunculia spp. sponges as a new class of cholinesterase inhibitors.	University of Maribor
28478343	55	Rational design, synthesis and biological screening of triazine-triazolopyrimidine hybrids as multitarget anti-Alzheimer agents.	Jamia Millia Islamia (Central University)
30017112	36	Developing hybrid molecule therapeutics for diverse enzyme inhibitory action: Active role of coumarin-based structural leads in drug discovery.	Abbottabad University of Science and Technology
29960728	29	Design, synthesis and evaluation of novel bivalent ?-carboline derivatives as multifunctional agents for the treatment of Alzheimer's disease.	China Pharmaceutical University
29887354	26	A cascade synthesis, in vitro cholinesterases inhibitory activity and docking studies of novel Tacrine-pyranopyrazole derivatives.	Fr£Res Mentouri-Constantine University
29886083	22	Synthesis, structure-activity relationship and molecular docking studies of 3-O-flavonol glycosides as cholinesterase inhibitors.	University of Gujrat
29866481	22	Design, synthesis and biological evaluation of benzofuran appended benzothiazepine derivatives as inhibitors of butyrylcholinesterase and antimicrobial agents.	Alzahra University
28605675	26	Isosteroidal alkaloids as potent dual-binding site inhibitors of both acetylcholinesterase and butyrylcholinesterase from the bulbs of Fritillaria walujewii.	Tianjin University of Technology
28587871	34	Synthesis, docking study and neuroprotective effects of some novel pyrano[3,2-c]chromene derivatives bearing morpholine/phenylpiperazine moiety.	Tehran University of Medical Sciences
28578994	28	Synthesis, molecular docking, and biological activity of polyfluoroalkyl dihydroazolo[5,1-c][1,2,4]triazines as selective carboxylesterase inhibitors.	Urals Branch of Russian Academy of Sciences
28576634	17	BACE1 inhibitory activity and molecular docking analysis of meroterpenoids from Sargassum serratifolium.	Pukyong National University
29033233	56	Design, synthesis and biological evaluation of 2-acetyl-5-O-(amino-alkyl)phenol derivatives as multifunctional agents for the treatment of Alzheimer's disease.	Nanyang Normal University
29033232	164	Design, synthesis and biological evaluation of phthalimide-alkylamine derivatives as balanced multifunctional cholinesterase and monoamine oxidase-B inhibitors for the treatment of Alzheimer's disease.	Nanyang Normal University
28986116	87	9-Substituted acridine derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors possessing antioxidant activity for Alzheimer's disease treatment.	Institute of Physiologically Active Compounds Russian Academy of Sciences
27863370	36	Novel tacrine-1,2,3-triazole hybrids: In vitro, in vivo biological evaluation and docking study of cholinesterase inhibitors.	Tehran University of Medical Sciences
27744252	102	Synthesis and evaluation of 7-substituted coumarin derivatives as multimodal monoamine oxidase-B and cholinesterase inhibitors for the treatment of Alzheimer's disease.	University of The Western Cape
28302511	34	Design, synthesis and biological evaluation of multifunctional tacrine-curcumin hybrids as new cholinesterase inhibitors with metal ions-chelating and neuroprotective property.	China Pharmaceutical University
28282613	21	Design, synthesis and evaluation of novel feruloyl-donepezil hybrids as potential multitarget drugs for the treatment of Alzheimer's disease.	Federal University of Alfenas
28487125	174	Design, synthesis and biological evaluation of 3,4-dihydro-2(1H)-quinoline-O-alkylamine derivatives as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.	Nanyang Normal University
28416102	19	Synthesis, biochemical evaluation, and molecular modeling studies of aryl and arylalkyl di-n-butyl phosphates, effective butyrylcholinesterase inhibitors.	California State University
28388521	28	Design, synthesis and biological activity of novel donepezil derivatives bearing N-benzyl pyridinium moiety as potent and dual binding site acetylcholinesterase inhibitors.	Shanghai University of Traditional Chinese Medicine
28371641	32	Recent progress in the identification of selective butyrylcholinesterase inhibitors for Alzheimer's disease.	China Pharmaceutical University
29400965	83	Structure-Activity Relationships and Computational Investigations into the Development of Potent and Balanced Dual-Acting Butyrylcholinesterase Inhibitors and Human Cannabinoid Receptor 2 Ligands with Pro-Cognitive in Vivo Profiles.	Julius Maximilian University of W£Rzburg
28457693	18	Antioxidant and anticholinesterase potential of diterpenoid alkaloids from Aconitum heterophyllum.	University of Malakand
28454848	32	Design, synthesis, and evaluation of multitarget-directed ligands against Alzheimer's disease based on the fusion of donepezil and curcumin.	Sun Yat-Sen University
28404526	23	Stereospecific cholinesterase inhibition by O,S-diethylphenylphosphonothioate.	University of Missouri St. Louis