Compile Data Set for Download or QSAR

Found 240 hits with Last Name = 'disingrini' and Initial = 't'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM191074 (US9181258, 82) Show SMILES CN1CCN(Cc2ccc(cc2)-c2c(cc3C(=O)NCC(CCOC(=O)C(F)(F)F)n23)-c2cccc(OC(F)(F)F)c2)CC1 Show InChI InChI=1S/C30H30F6N4O4/c1-38-10-12-39(13-11-38)18-19-5-7-20(8-6-19)26-24(21-3-2-4-23(15-21)44-30(34,35)36)16-25-27(41)37-17-22(40(25)26)9-14-43-28(42)29(31,32)33/h2-8,15-16,22H,9-14,17-18H2,1H3,(H,37,41)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.5	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...				US Patent US9181258 (2015) BindingDB Entry DOI: 10.7270/Q2862F7F
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM191095 (US9181258, 93) Show SMILES NCC[C@H]1CNC(=O)c2cc(c(-c3ccc(O)cc3)n12)-c1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C22H20F3N3O3/c23-22(24,25)31-17-3-1-2-14(10-17)18-11-19-21(30)27-12-15(8-9-26)28(19)20(18)13-4-6-16(29)7-5-13/h1-7,10-11,15,29H,8-9,12,26H2,(H,27,30)/t15-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.5	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...				US Patent US9181258 (2015) BindingDB Entry DOI: 10.7270/Q2862F7F
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM191100 (US9181258, 96) Show SMILES CS(=O)(=O)c1ccc(cc1)-c1c(cc2C(=O)NC[C@H](CCN)n12)-c1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C23H22F3N3O4S/c1-34(31,32)18-7-5-14(6-8-18)21-19(15-3-2-4-17(11-15)33-23(24,25)26)12-20-22(30)28-13-16(9-10-27)29(20)21/h2-8,11-12,16H,9-10,13,27H2,1H3,(H,28,30)/t16-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.5	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...				US Patent US9181258 (2015) BindingDB Entry DOI: 10.7270/Q2862F7F
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM191103 (US9181258, 100) Show SMILES CN1CCN(Cc2ccc(cc2)-c2c(cc3C(=O)NC[C@H](CCN)n23)-c2cccc(OC(F)(F)F)c2)CC1 Show InChI InChI=1S/C28H32F3N5O2/c1-34-11-13-35(14-12-34)18-19-5-7-20(8-6-19)26-24(21-3-2-4-23(15-21)38-28(29,30)31)16-25-27(37)33-17-22(9-10-32)36(25)26/h2-8,15-16,22H,9-14,17-18,32H2,1H3,(H,33,37)/t22-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.5	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...				US Patent US9181258 (2015) BindingDB Entry DOI: 10.7270/Q2862F7F
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM191104 (US9181258, 101) Show SMILES CN(C)Cc1ccc(cc1)-c1c(cc2C(=O)NC[C@H](CCN)n12)-c1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C25H27F3N4O2/c1-31(2)15-16-6-8-17(9-7-16)23-21(18-4-3-5-20(12-18)34-25(26,27)28)13-22-24(33)30-14-19(10-11-29)32(22)23/h3-9,12-13,19H,10-11,14-15,29H2,1-2H3,(H,30,33)/t19-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.5	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...				US Patent US9181258 (2015) BindingDB Entry DOI: 10.7270/Q2862F7F
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM191114 (US9181258, 135) Show SMILES CN1CCN(Cc2ccc(cc2)-c2c(cc3C(=O)NC[C@H](CCCN)n23)-c2cccc(OC(F)(F)F)c2)CC1 Show InChI InChI=1S/C29H34F3N5O2/c1-35-12-14-36(15-13-35)19-20-7-9-21(10-8-20)27-25(22-4-2-6-24(16-22)39-29(30,31)32)17-26-28(38)34-18-23(37(26)27)5-3-11-33/h2,4,6-10,16-17,23H,3,5,11-15,18-19,33H2,1H3,(H,34,38)/t23-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.5	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...				US Patent US9181258 (2015) BindingDB Entry DOI: 10.7270/Q2862F7F
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM191119 (US9181258, 120) Show SMILES NCC[C@H]1CNC(=O)c2cc(c(-c3ccc(cc3)S(N)(=O)=O)n12)-c1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C22H21F3N4O4S/c23-22(24,25)33-16-3-1-2-14(10-16)18-11-19-21(30)28-12-15(8-9-26)29(19)20(18)13-4-6-17(7-5-13)34(27,31)32/h1-7,10-11,15H,8-9,12,26H2,(H,28,30)(H2,27,31,32)/t15-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.5	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...				US Patent US9181258 (2015) BindingDB Entry DOI: 10.7270/Q2862F7F
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM191129 (US9181258, 130) Show SMILES NCC[C@H]1CNC(=O)c2cc(c(-c3ccc(cc3)C3(N)CC3)n12)-c1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C25H25F3N4O2/c26-25(27,28)34-19-3-1-2-16(12-19)20-13-21-23(33)31-14-18(8-11-29)32(21)22(20)15-4-6-17(7-5-15)24(30)9-10-24/h1-7,12-13,18H,8-11,14,29-30H2,(H,31,33)/t18-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.5	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...				US Patent US9181258 (2015) BindingDB Entry DOI: 10.7270/Q2862F7F
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM191102 (US9181258, 99) Show SMILES NCC[C@H]1CNC(=O)c2cc(c(-c3ccc(CN4CCOCC4)cc3)n12)-c1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C27H29F3N4O3/c28-27(29,30)37-22-3-1-2-20(14-22)23-15-24-26(35)32-16-21(8-9-31)34(24)25(23)19-6-4-18(5-7-19)17-33-10-12-36-13-11-33/h1-7,14-15,21H,8-13,16-17,31H2,(H,32,35)/t21-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	7.5	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...				US Patent US9181258 (2015) BindingDB Entry DOI: 10.7270/Q2862F7F
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM191113 (US9181258, 134) Show SMILES CN(C)Cc1ccc(cc1)-c1c(cc2C(=O)NC[C@H](CCCN)n12)-c1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C26H29F3N4O2/c1-32(2)16-17-8-10-18(11-9-17)24-22(19-5-3-7-21(13-19)35-26(27,28)29)14-23-25(34)31-15-20(33(23)24)6-4-12-30/h3,5,7-11,13-14,20H,4,6,12,15-16,30H2,1-2H3,(H,31,34)/t20-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	7.5	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...				US Patent US9181258 (2015) BindingDB Entry DOI: 10.7270/Q2862F7F
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM191103 (US9181258, 100) Show SMILES CN1CCN(Cc2ccc(cc2)-c2c(cc3C(=O)NC[C@H](CCN)n23)-c2cccc(OC(F)(F)F)c2)CC1 Show InChI InChI=1S/C28H32F3N5O2/c1-34-11-13-35(14-12-34)18-19-5-7-20(8-6-19)26-24(21-3-2-4-23(15-21)38-28(29,30)31)16-25-27(37)33-17-22(9-10-32)36(25)26/h2-8,15-16,22H,9-14,17-18,32H2,1H3,(H,33,37)/t22-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	7.5	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...				US Patent US9181258 (2015) BindingDB Entry DOI: 10.7270/Q2862F7F
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM31532 (pyrazolo[4,3-h]quinazoline-3-carboxamide, 1) Show SMILES Cn1nc(C(N)=O)c2CCc3cnc(Nc4ccccc4)nc3-c12 Show InChI InChI=1S/C17H16N6O/c1-23-15-12(14(22-23)16(18)24)8-7-10-9-19-17(21-13(10)15)20-11-5-3-2-4-6-11/h2-6,9H,7-8H2,1H3,(H2,18,24)(H,19,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Nerviano Medical Sciences srl Curated by ChEMBL					Assay Description Inhibition of CDK2/Cyclin A assessed as [33P]-gamma-ATP incorporation into substrate by gamma counting				Bioorg Med Chem Lett 21: 4507-11 (2011) Article DOI: 10.1016/j.bmcl.2011.05.122 BindingDB Entry DOI: 10.7270/Q2R211RS
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM191109 (US9181258, 116) Show SMILES COc1ccc(cc1)-c1c(cc2C(=O)NC[C@H](CCN)n12)-c1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C23H22F3N3O3/c1-31-17-7-5-14(6-8-17)21-19(15-3-2-4-18(11-15)32-23(24,25)26)12-20-22(30)28-13-16(9-10-27)29(20)21/h2-8,11-12,16H,9-10,13,27H2,1H3,(H,28,30)/t16-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.5	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...				US Patent US9181258 (2015) BindingDB Entry DOI: 10.7270/Q2862F7F
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM191110 (US9181258, 115) Show SMILES CN(C)c1ccc(cc1)-c1c(cc2C(=O)NC[C@H](CCN)n12)-c1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C24H25F3N4O2/c1-30(2)17-8-6-15(7-9-17)22-20(16-4-3-5-19(12-16)33-24(25,26)27)13-21-23(32)29-14-18(10-11-28)31(21)22/h3-9,12-13,18H,10-11,14,28H2,1-2H3,(H,29,32)/t18-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.5	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...				US Patent US9181258 (2015) BindingDB Entry DOI: 10.7270/Q2862F7F
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM191126 (US9181258, 121) Show SMILES NCC[C@H]1CNC(=O)c2cc(c(-c3cccc(F)c3)n12)-c1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C22H19F4N3O2/c23-15-5-1-4-14(9-15)20-18(13-3-2-6-17(10-13)31-22(24,25)26)11-19-21(30)28-12-16(7-8-27)29(19)20/h1-6,9-11,16H,7-8,12,27H2,(H,28,30)/t16-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.5	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...				US Patent US9181258 (2015) BindingDB Entry DOI: 10.7270/Q2862F7F
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM191120 (US9181258, 126 | US9181258, 129) Show SMILES COc1ccc(cc1Cl)-c1c(cc2C(=O)NC[C@H](CCN)n12)-c1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C23H21ClF3N3O3/c1-32-20-6-5-14(10-18(20)24)21-17(13-3-2-4-16(9-13)33-23(25,26)27)11-19-22(31)29-12-15(7-8-28)30(19)21/h2-6,9-11,15H,7-8,12,28H2,1H3,(H,29,31)/t15-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.5	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...				US Patent US9181258 (2015) BindingDB Entry DOI: 10.7270/Q2862F7F
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM191100 (US9181258, 96) Show SMILES CS(=O)(=O)c1ccc(cc1)-c1c(cc2C(=O)NC[C@H](CCN)n12)-c1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C23H22F3N3O4S/c1-34(31,32)18-7-5-14(6-8-18)21-19(15-3-2-4-17(11-15)33-23(24,25)26)12-20-22(30)28-13-16(9-10-27)29(20)21/h2-8,11-12,16H,9-10,13,27H2,1H3,(H,28,30)/t16-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.5	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...				US Patent US9181258 (2015) BindingDB Entry DOI: 10.7270/Q2862F7F
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM191119 (US9181258, 120) Show SMILES NCC[C@H]1CNC(=O)c2cc(c(-c3ccc(cc3)S(N)(=O)=O)n12)-c1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C22H21F3N4O4S/c23-22(24,25)33-16-3-1-2-14(10-16)18-11-19-21(30)28-12-15(8-9-26)29(19)20(18)13-4-6-17(7-5-13)34(27,31)32/h1-7,10-11,15H,8-9,12,26H2,(H,28,30)(H2,27,31,32)/t15-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.5	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...				US Patent US9181258 (2015) BindingDB Entry DOI: 10.7270/Q2862F7F
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM191129 (US9181258, 130) Show SMILES NCC[C@H]1CNC(=O)c2cc(c(-c3ccc(cc3)C3(N)CC3)n12)-c1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C25H25F3N4O2/c26-25(27,28)34-19-3-1-2-16(12-19)20-13-21-23(33)31-14-18(8-11-29)32(21)22(20)15-4-6-17(7-5-15)24(30)9-10-24/h1-7,12-13,18H,8-11,14,29-30H2,(H,31,33)/t18-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.5	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...				US Patent US9181258 (2015) BindingDB Entry DOI: 10.7270/Q2862F7F
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50318085 (1-Methyl-8-[(2-methylphenyl)amino]-4,5-dihydro-1H-...) Show SMILES Cc1ccccc1Nc1ncc2CCc3c(nn(C)c3-c2n1)C(N)=O Show InChI InChI=1S/C18H18N6O/c1-10-5-3-4-6-13(10)21-18-20-9-11-7-8-12-15(17(19)25)23-24(2)16(12)14(11)22-18/h3-6,9H,7-8H2,1-2H3,(H2,19,25)(H,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Nerviano Medical Sciences srl Curated by ChEMBL					Assay Description Inhibition of CDK2/Cyclin A assessed as [33P]-gamma-ATP incorporation into substrate by gamma counting				Bioorg Med Chem Lett 21: 4507-11 (2011) Article DOI: 10.1016/j.bmcl.2011.05.122 BindingDB Entry DOI: 10.7270/Q2R211RS
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM191075 (US9181258, 83) Show SMILES CN(C)Cc1ccc(cc1)-c1c(cc2C(=O)NCC(CCOC(=O)C(F)(F)F)n12)-c1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C27H25F6N3O4/c1-35(2)15-16-6-8-17(9-7-16)23-21(18-4-3-5-20(12-18)40-27(31,32)33)13-22-24(37)34-14-19(36(22)23)10-11-39-25(38)26(28,29)30/h3-9,12-13,19H,10-11,14-15H2,1-2H3,(H,34,37)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	7.5	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...				US Patent US9181258 (2015) BindingDB Entry DOI: 10.7270/Q2862F7F
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM191083 (US9181258, 33) Show SMILES NCCC1CNC(=O)c2cc(c(-c3ccc(CO)cc3)n12)-c1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C23H22F3N3O3/c24-23(25,26)32-18-3-1-2-16(10-18)19-11-20-22(31)28-12-17(8-9-27)29(20)21(19)15-6-4-14(13-30)5-7-15/h1-7,10-11,17,30H,8-9,12-13,27H2,(H,28,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	7.5	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...				US Patent US9181258 (2015) BindingDB Entry DOI: 10.7270/Q2862F7F
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM191107 (US9181258, 104) Show SMILES NCCC[C@H]1CNC(=O)c2cc(c(-c3ccc(O)cc3)n12)-c1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C23H22F3N3O3/c24-23(25,26)32-18-5-1-3-15(11-18)19-12-20-22(31)28-13-16(4-2-10-27)29(20)21(19)14-6-8-17(30)9-7-14/h1,3,5-9,11-12,16,30H,2,4,10,13,27H2,(H,28,31)/t16-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	7.5	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...				US Patent US9181258 (2015) BindingDB Entry DOI: 10.7270/Q2862F7F
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM191078 (US9181258, 92) Show SMILES Cc1cccc(c1)-c1c(cc2C(=O)NC[C@H](CCN)n12)-c1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C23H22F3N3O2/c1-14-4-2-6-16(10-14)21-19(15-5-3-7-18(11-15)31-23(24,25)26)12-20-22(30)28-13-17(8-9-27)29(20)21/h2-7,10-12,17H,8-9,13,27H2,1H3,(H,28,30)/t17-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	7.5	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...				US Patent US9181258 (2015) BindingDB Entry DOI: 10.7270/Q2862F7F
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM191091 (US9181258, 78) Show SMILES CN(C)CCNC(=O)c1ccc(cc1)-c1c(cc2C(=O)NCC(CCO)n12)-c1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C27H29F3N4O4/c1-33(2)12-11-31-25(36)18-8-6-17(7-9-18)24-22(19-4-3-5-21(14-19)38-27(28,29)30)15-23-26(37)32-16-20(10-13-35)34(23)24/h3-9,14-15,20,35H,10-13,16H2,1-2H3,(H,31,36)(H,32,37)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	7.5	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...				US Patent US9181258 (2015) BindingDB Entry DOI: 10.7270/Q2862F7F
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM191099 (US9181258, 95) Show SMILES CC(=O)c1ccc(cc1)-c1c(cc2C(=O)NC[C@H](CCN)n12)-c1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C24H22F3N3O3/c1-14(31)15-5-7-16(8-6-15)22-20(17-3-2-4-19(11-17)33-24(25,26)27)12-21-23(32)29-13-18(9-10-28)30(21)22/h2-8,11-12,18H,9-10,13,28H2,1H3,(H,29,32)/t18-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	7.5	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...				US Patent US9181258 (2015) BindingDB Entry DOI: 10.7270/Q2862F7F
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM191117 (US9181258, 112) Show SMILES NCC[C@H]1CNC(=O)c2cc(c(-c3ccc4OCOc4c3)n12)-c1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C23H20F3N3O4/c24-23(25,26)33-16-3-1-2-13(8-16)17-10-18-22(30)28-11-15(6-7-27)29(18)21(17)14-4-5-19-20(9-14)32-12-31-19/h1-5,8-10,15H,6-7,11-12,27H2,(H,28,30)/t15-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	7.5	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...				US Patent US9181258 (2015) BindingDB Entry DOI: 10.7270/Q2862F7F
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM191070 (US9181258, 28) Show SMILES NCCC1CNC(=O)c2cc(c(-c3ccccc3)n12)-c1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C22H20F3N3O2/c23-22(24,25)30-17-8-4-7-15(11-17)18-12-19-21(29)27-13-16(9-10-26)28(19)20(18)14-5-2-1-3-6-14/h1-8,11-12,16H,9-10,13,26H2,(H,27,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	7.5	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...				US Patent US9181258 (2015) BindingDB Entry DOI: 10.7270/Q2862F7F
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM191089 (US9181258, 77) Show SMILES NC(=O)c1ccc(cc1)-c1c(cc2C(=O)NCC(CCO)n12)-c1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C23H20F3N3O4/c24-23(25,26)33-17-3-1-2-15(10-17)18-11-19-22(32)28-12-16(8-9-30)29(19)20(18)13-4-6-14(7-5-13)21(27)31/h1-7,10-11,16,30H,8-9,12H2,(H2,27,31)(H,28,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	7.5	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...				US Patent US9181258 (2015) BindingDB Entry DOI: 10.7270/Q2862F7F
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM191101 (US9181258, 97) Show SMILES NCC[C@H]1CNC(=O)c2cc(c(-c3ccc(C=O)cc3)n12)-c1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C23H20F3N3O3/c24-23(25,26)32-18-3-1-2-16(10-18)19-11-20-22(31)28-12-17(8-9-27)29(20)21(19)15-6-4-14(13-30)5-7-15/h1-7,10-11,13,17H,8-9,12,27H2,(H,28,31)/t17-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	7.5	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...				US Patent US9181258 (2015) BindingDB Entry DOI: 10.7270/Q2862F7F
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM191102 (US9181258, 99) Show SMILES NCC[C@H]1CNC(=O)c2cc(c(-c3ccc(CN4CCOCC4)cc3)n12)-c1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C27H29F3N4O3/c28-27(29,30)37-22-3-1-2-20(14-22)23-15-24-26(35)32-16-21(8-9-31)34(24)25(23)19-6-4-18(5-7-19)17-33-10-12-36-13-11-33/h1-7,14-15,21H,8-13,16-17,31H2,(H,32,35)/t21-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	7.5	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...				US Patent US9181258 (2015) BindingDB Entry DOI: 10.7270/Q2862F7F
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM191081 (US9181258, 32) Show SMILES NCCC1CNC(=O)c2cc(c(-c3cccc(N)c3)n12)-c1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C22H21F3N4O2/c23-22(24,25)31-17-6-2-3-13(10-17)18-11-19-21(30)28-12-16(7-8-26)29(19)20(18)14-4-1-5-15(27)9-14/h1-6,9-11,16H,7-8,12,26-27H2,(H,28,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	7.5	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...				US Patent US9181258 (2015) BindingDB Entry DOI: 10.7270/Q2862F7F
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM191122 (US9181258, 128) Show SMILES COc1c(C)cc(cc1C)-c1c(cc2C(=O)NC[C@H](CCN)n12)-c1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C25H26F3N3O3/c1-14-9-17(10-15(2)23(14)33-3)22-20(16-5-4-6-19(11-16)34-25(26,27)28)12-21-24(32)30-13-18(7-8-29)31(21)22/h4-6,9-12,18H,7-8,13,29H2,1-3H3,(H,30,32)/t18-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	7.5	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...				US Patent US9181258 (2015) BindingDB Entry DOI: 10.7270/Q2862F7F
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM191132 (US9181258, 148) Show SMILES Cc1cccc(c1)-c1c(cc2C(=O)NC[C@H](CCNC(N)=N)n12)-c1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C24H24F3N5O2/c1-14-4-2-6-16(10-14)21-19(15-5-3-7-18(11-15)34-24(25,26)27)12-20-22(33)31-13-17(32(20)21)8-9-30-23(28)29/h2-7,10-12,17H,8-9,13H2,1H3,(H,31,33)(H4,28,29,30)/t17-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	7.5	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...				US Patent US9181258 (2015) BindingDB Entry DOI: 10.7270/Q2862F7F
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM191133 (US9181258, 149) Show SMILES CS(=O)(=O)c1ccc(cc1)-c1c(cc2C(=O)NC[C@H](CCNC(N)=N)n12)-c1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C24H24F3N5O4S/c1-37(34,35)18-7-5-14(6-8-18)21-19(15-3-2-4-17(11-15)36-24(25,26)27)12-20-22(33)31-13-16(32(20)21)9-10-30-23(28)29/h2-8,11-12,16H,9-10,13H2,1H3,(H,31,33)(H4,28,29,30)/t16-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	7.5	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...				US Patent US9181258 (2015) BindingDB Entry DOI: 10.7270/Q2862F7F
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM191077 (US9181258, 87) Show SMILES NCC[C@H]1CNC(=O)c2cc(c(-c3ccccc3)n12)-c1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C22H20F3N3O2/c23-22(24,25)30-17-8-4-7-15(11-17)18-12-19-21(29)27-13-16(9-10-26)28(19)20(18)14-5-2-1-3-6-14/h1-8,11-12,16H,9-10,13,26H2,(H,27,29)/t16-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	7.5	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...				US Patent US9181258 (2015) BindingDB Entry DOI: 10.7270/Q2862F7F
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM191104 (US9181258, 101) Show SMILES CN(C)Cc1ccc(cc1)-c1c(cc2C(=O)NC[C@H](CCN)n12)-c1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C25H27F3N4O2/c1-31(2)15-16-6-8-17(9-7-16)23-21(18-4-3-5-20(12-18)34-25(26,27)28)13-22-24(33)30-14-19(10-11-29)32(22)23/h3-9,12-13,19H,10-11,14-15,29H2,1-2H3,(H,30,33)/t19-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	7.5	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...				US Patent US9181258 (2015) BindingDB Entry DOI: 10.7270/Q2862F7F
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM191092 (US9181258, 81) Show SMILES CN1CCC(CC1)NC(=O)c1ccc(cc1)-c1c(cc2C(=O)NCC(CCO)n12)-c1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C29H31F3N4O4/c1-35-12-9-21(10-13-35)34-27(38)19-7-5-18(6-8-19)26-24(20-3-2-4-23(15-20)40-29(30,31)32)16-25-28(39)33-17-22(11-14-37)36(25)26/h2-8,15-16,21-22,37H,9-14,17H2,1H3,(H,33,39)(H,34,38)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	7.5	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...				US Patent US9181258 (2015) BindingDB Entry DOI: 10.7270/Q2862F7F
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM191094 (US9181258, 84) Show SMILES OCCC1CNC(=O)c2cc(c(-c3ccc(CO)cc3)n12)-c1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C23H21F3N2O4/c24-23(25,26)32-18-3-1-2-16(10-18)19-11-20-22(31)27-12-17(8-9-29)28(20)21(19)15-6-4-14(13-30)5-7-15/h1-7,10-11,17,29-30H,8-9,12-13H2,(H,27,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	7.5	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...				US Patent US9181258 (2015) BindingDB Entry DOI: 10.7270/Q2862F7F
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM191106 (US9181258, 103) Show SMILES NCCC[C@H]1CNC(=O)c2cc(c(-c3ccsc3)n12)-c1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C21H20F3N3O2S/c22-21(23,24)29-16-5-1-3-13(9-16)17-10-18-20(28)26-11-15(4-2-7-25)27(18)19(17)14-6-8-30-12-14/h1,3,5-6,8-10,12,15H,2,4,7,11,25H2,(H,26,28)/t15-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	7.5	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...				US Patent US9181258 (2015) BindingDB Entry DOI: 10.7270/Q2862F7F
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM191112 (US9181258, 109) Show SMILES CS(=O)(=O)c1ccc(cc1)-c1c(cc2C(=O)NC[C@H](CCCN)n12)-c1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C24H24F3N3O4S/c1-35(32,33)19-9-7-15(8-10-19)22-20(16-4-2-6-18(12-16)34-24(25,26)27)13-21-23(31)29-14-17(30(21)22)5-3-11-28/h2,4,6-10,12-13,17H,3,5,11,14,28H2,1H3,(H,29,31)/t17-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	7.5	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...				US Patent US9181258 (2015) BindingDB Entry DOI: 10.7270/Q2862F7F
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM191076 (US9181258, 85) Show SMILES NCC[C@H]1CNC(=O)c2cc(c(-c3ccsc3)n12)-c1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C20H18F3N3O2S/c21-20(22,23)28-15-3-1-2-12(8-15)16-9-17-19(27)25-10-14(4-6-24)26(17)18(16)13-5-7-29-11-13/h1-3,5,7-9,11,14H,4,6,10,24H2,(H,25,27)/t14-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	7.5	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...				US Patent US9181258 (2015) BindingDB Entry DOI: 10.7270/Q2862F7F
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM191088 (US9181258, 43) Show SMILES NCCC1CNC(=O)c2cc(c(-c3ccc(O)cc3)n12)-c1cccc(c1)C(F)(F)F Show InChI InChI=1S/C22H20F3N3O2/c23-22(24,25)15-3-1-2-14(10-15)18-11-19-21(30)27-12-16(8-9-26)28(19)20(18)13-4-6-17(29)7-5-13/h1-7,10-11,16,29H,8-9,12,26H2,(H,27,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	7.5	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...				US Patent US9181258 (2015) BindingDB Entry DOI: 10.7270/Q2862F7F
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM191121 (US9181258, 127) Show SMILES CCOc1ccc(cc1F)-c1c(cc2C(=O)NC[C@H](CCN)n12)-c1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C24H23F4N3O3/c1-2-33-21-7-6-15(11-19(21)25)22-18(14-4-3-5-17(10-14)34-24(26,27)28)12-20-23(32)30-13-16(8-9-29)31(20)22/h3-7,10-12,16H,2,8-9,13,29H2,1H3,(H,30,32)/t16-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	7.5	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...				US Patent US9181258 (2015) BindingDB Entry DOI: 10.7270/Q2862F7F
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM191131 (US9181258, 138) Show SMILES CC(C)[C@H]1CNC(=O)c2cc(c(-c3ccc(CN)cc3)n12)-c1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C24H24F3N3O2/c1-14(2)21-13-29-23(31)20-11-19(17-4-3-5-18(10-17)32-24(25,26)27)22(30(20)21)16-8-6-15(12-28)7-9-16/h3-11,14,21H,12-13,28H2,1-2H3,(H,29,31)/t21-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	7.5	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...				US Patent US9181258 (2015) BindingDB Entry DOI: 10.7270/Q2862F7F
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM191126 (US9181258, 121) Show SMILES NCC[C@H]1CNC(=O)c2cc(c(-c3cccc(F)c3)n12)-c1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C22H19F4N3O2/c23-15-5-1-4-14(9-15)20-18(13-3-2-6-17(10-13)31-22(24,25)26)11-19-21(30)28-12-16(7-8-27)29(19)20/h1-6,9-11,16H,7-8,12,27H2,(H,28,30)/t16-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	7.5	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...				US Patent US9181258 (2015) BindingDB Entry DOI: 10.7270/Q2862F7F
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM191120 (US9181258, 126 | US9181258, 129) Show SMILES COc1ccc(cc1Cl)-c1c(cc2C(=O)NC[C@H](CCN)n12)-c1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C23H21ClF3N3O3/c1-32-20-6-5-14(10-18(20)24)21-17(13-3-2-4-16(9-13)33-23(25,26)27)11-19-22(31)29-12-15(7-8-28)30(19)21/h2-6,9-11,15H,7-8,12,28H2,1H3,(H,29,31)/t15-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	7.5	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...				US Patent US9181258 (2015) BindingDB Entry DOI: 10.7270/Q2862F7F
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM191132 (US9181258, 148) Show SMILES Cc1cccc(c1)-c1c(cc2C(=O)NC[C@H](CCNC(N)=N)n12)-c1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C24H24F3N5O2/c1-14-4-2-6-16(10-14)21-19(15-5-3-7-18(11-15)34-24(25,26)27)12-20-22(33)31-13-17(32(20)21)8-9-30-23(28)29/h2-7,10-12,17H,8-9,13H2,1H3,(H,31,33)(H4,28,29,30)/t17-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	7.5	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...				US Patent US9181258 (2015) BindingDB Entry DOI: 10.7270/Q2862F7F
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM191090 (US9181258, 79) Show SMILES CN(C)C(=O)c1ccc(cc1)-c1c(cc2C(=O)NCC(CCO)n12)-c1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C25H24F3N3O4/c1-30(2)24(34)16-8-6-15(7-9-16)22-20(17-4-3-5-19(12-17)35-25(26,27)28)13-21-23(33)29-14-18(10-11-32)31(21)22/h3-9,12-13,18,32H,10-11,14H2,1-2H3,(H,29,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	7.5	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...				US Patent US9181258 (2015) BindingDB Entry DOI: 10.7270/Q2862F7F
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM191120 (US9181258, 126 | US9181258, 129) Show SMILES COc1ccc(cc1Cl)-c1c(cc2C(=O)NC[C@H](CCN)n12)-c1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C23H21ClF3N3O3/c1-32-20-6-5-14(10-18(20)24)21-17(13-3-2-4-16(9-13)33-23(25,26)27)11-19-22(31)29-12-15(7-8-28)30(19)21/h2-6,9-11,15H,7-8,12,28H2,1H3,(H,29,31)/t15-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	7.5	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...				US Patent US9181258 (2015) BindingDB Entry DOI: 10.7270/Q2862F7F
					More data for this Ligand-Target Pair

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