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USPatent US8575201

Compile data set for download or QSAR
Found 175 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104552
PNG
(US8575201, 43)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1ccc(nc1)N1CC[C@@H](O)C1 |r|
Show InChI InChI=1S/C24H24N8O2/c25-23-28-11-16(12-29-23)19-4-3-17(13-26-19)24(7-1-8-24)22-30-21(34-31-22)15-2-5-20(27-10-15)32-9-6-18(33)14-32/h2-5,10-13,18,33H,1,6-9,14H2,(H2,25,28,29)/t18-/m1/s1
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n/an/a 1.20n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104623
PNG
(US8575201, 114)
Show SMILES CC(C)Nc1ccc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C23H24N8O/c1-14(2)29-19-7-4-15(10-26-19)20-30-21(31-32-20)23(8-3-9-23)17-5-6-18(25-13-17)16-11-27-22(24)28-12-16/h4-7,10-14H,3,8-9H2,1-2H3,(H,26,29)(H2,24,27,28)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104634
PNG
(US8575201, 125)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1ccc(nc1)N1CCNC(=O)C1
Show InChI InChI=1S/C24H23N9O2/c25-23-29-11-16(12-30-23)18-4-3-17(13-27-18)24(6-1-7-24)22-31-21(35-32-22)15-2-5-19(28-10-15)33-9-8-26-20(34)14-33/h2-5,10-13H,1,6-9,14H2,(H,26,34)(H2,25,29,30)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104570
PNG
(US8575201, 61)
Show SMILES CN1CCN(CC1)c1cnc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C24H26N10O/c1-33-7-9-34(10-8-33)20-15-27-19(14-28-20)21-31-22(32-35-21)24(5-2-6-24)17-3-4-18(26-13-17)16-11-29-23(25)30-12-16/h3-4,11-15H,2,5-10H2,1H3,(H2,25,29,30)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104527
PNG
(US8575201, 18)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1ccc(NCC2(O)CC2)nc1
Show InChI InChI=1S/C24H24N8O2/c25-22-28-11-16(12-29-22)18-4-3-17(13-26-18)24(6-1-7-24)21-31-20(34-32-21)15-2-5-19(27-10-15)30-14-23(33)8-9-23/h2-5,10-13,33H,1,6-9,14H2,(H,27,30)(H2,25,28,29)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104540
PNG
(US8575201, 31)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1ccc(nc1)-n1ccnc1
Show InChI InChI=1S/C23H19N9O/c24-22-28-11-16(12-29-22)18-4-3-17(13-26-18)23(6-1-7-23)21-30-20(33-31-21)15-2-5-19(27-10-15)32-9-8-25-14-32/h2-5,8-14H,1,6-7H2,(H2,24,28,29)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104624
PNG
(US8575201, 115)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1ccc(NCCO)nc1
Show InChI InChI=1S/C22H22N8O2/c23-21-27-11-15(12-28-21)17-4-3-16(13-25-17)22(6-1-7-22)20-29-19(32-30-20)14-2-5-18(26-10-14)24-8-9-31/h2-5,10-13,31H,1,6-9H2,(H,24,26)(H2,23,27,28)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104517
PNG
(US8575201, 8)
Show SMILES CCNc1ccc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C22H22N8O/c1-2-24-18-7-4-14(10-26-18)19-29-20(30-31-19)22(8-3-9-22)16-5-6-17(25-13-16)15-11-27-21(23)28-12-15/h4-7,10-13H,2-3,8-9H2,1H3,(H,24,26)(H2,23,27,28)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104521
PNG
(US8575201, 12)
Show SMILES CC(C)(O)CNc1ccc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C24H26N8O2/c1-23(2,33)14-30-19-7-4-15(10-27-19)20-31-21(32-34-20)24(8-3-9-24)17-5-6-18(26-13-17)16-11-28-22(25)29-12-16/h4-7,10-13,33H,3,8-9,14H2,1-2H3,(H,27,30)(H2,25,28,29)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104542
PNG
(US8575201, 33)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1ccc(NC(CO)CO)nc1
Show InChI InChI=1S/C23H24N8O3/c24-22-27-9-15(10-28-22)18-4-3-16(11-25-18)23(6-1-7-23)21-30-20(34-31-21)14-2-5-19(26-8-14)29-17(12-32)13-33/h2-5,8-11,17,32-33H,1,6-7,12-13H2,(H,26,29)(H2,24,27,28)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104557
PNG
(US8575201, 48)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1ccc(nc1)N1CC[C@H](O)C1 |r|
Show InChI InChI=1S/C24H24N8O2/c25-23-28-11-16(12-29-23)19-4-3-17(13-26-19)24(7-1-8-24)22-30-21(34-31-22)15-2-5-20(27-10-15)32-9-6-18(33)14-32/h2-5,10-13,18,33H,1,6-9,14H2,(H2,25,28,29)/t18-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104566
PNG
(US8575201, 57)
Show SMILES CCNc1cnc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C21H21N9O/c1-2-23-17-12-25-16(11-26-17)18-29-19(30-31-18)21(6-3-7-21)14-4-5-15(24-10-14)13-8-27-20(22)28-9-13/h4-5,8-12H,2-3,6-7H2,1H3,(H,23,26)(H2,22,27,28)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104619
PNG
(US8575201, 110)
Show SMILES CN(C)c1ccc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C22H22N8O/c1-30(2)18-7-4-14(10-25-18)19-28-20(29-31-19)22(8-3-9-22)16-5-6-17(24-13-16)15-11-26-21(23)27-12-15/h4-7,10-13H,3,8-9H2,1-2H3,(H2,23,26,27)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104555
PNG
(US8575201, 46)
Show SMILES C[C@H](O)CNc1ccc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1 |r|
Show InChI InChI=1S/C23H24N8O2/c1-14(32)9-26-19-6-3-15(10-27-19)20-30-21(31-33-20)23(7-2-8-23)17-4-5-18(25-13-17)16-11-28-22(24)29-12-16/h3-6,10-14,32H,2,7-9H2,1H3,(H,26,27)(H2,24,28,29)/t14-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104622
PNG
(US8575201, 113)
Show SMILES CNc1ccc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C21H20N8O/c1-23-17-6-3-13(9-25-17)18-28-19(29-30-18)21(7-2-8-21)15-4-5-16(24-12-15)14-10-26-20(22)27-11-14/h3-6,9-12H,2,7-8H2,1H3,(H,23,25)(H2,22,26,27)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104531
PNG
(US8575201, 22)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1ccc(OCCO)nc1
Show InChI InChI=1S/C22H21N7O3/c23-21-26-11-15(12-27-21)17-4-3-16(13-24-17)22(6-1-7-22)20-28-19(32-29-20)14-2-5-18(25-10-14)31-9-8-30/h2-5,10-13,30H,1,6-9H2,(H2,23,26,27)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104561
PNG
(US8575201, 52)
Show SMILES CS(=O)(=O)C1CCN(C1)c1ccc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C25H26N8O3S/c1-37(34,35)19-7-10-33(15-19)21-6-3-16(11-28-21)22-31-23(32-36-22)25(8-2-9-25)18-4-5-20(27-14-18)17-12-29-24(26)30-13-17/h3-6,11-14,19H,2,7-10,15H2,1H3,(H2,26,29,30)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104530
PNG
(US8575201, 21)
Show SMILES CC(C)(CO)Nc1ccc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C24H26N8O2/c1-23(2,14-33)31-19-7-4-15(10-27-19)20-30-21(32-34-20)24(8-3-9-24)17-5-6-18(26-13-17)16-11-28-22(25)29-12-16/h4-7,10-13,33H,3,8-9,14H2,1-2H3,(H,27,31)(H2,25,28,29)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104562
PNG
(US8575201, 53)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1ccc(nc1)N1CCN(CCC(O)=O)CC1
Show InChI InChI=1S/C27H29N9O3/c28-26-31-15-19(16-32-26)21-4-3-20(17-29-21)27(7-1-8-27)25-33-24(39-34-25)18-2-5-22(30-14-18)36-12-10-35(11-13-36)9-6-23(37)38/h2-5,14-17H,1,6-13H2,(H,37,38)(H2,28,31,32)
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n/an/a 2.60n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104571
PNG
(US8575201, 62)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1ccc(cc1)N1CCNCC1
Show InChI InChI=1S/C25H26N8O/c26-24-29-14-18(15-30-24)21-7-4-19(16-28-21)25(8-1-9-25)23-31-22(34-32-23)17-2-5-20(6-3-17)33-12-10-27-11-13-33/h2-7,14-16,27H,1,8-13H2,(H2,26,29,30)
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n/an/a 2.60n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104512
PNG
(US8575201, 3)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1ccc(nc1)N1CCNCC1
Show InChI InChI=1S/C24H25N9O/c25-23-29-13-17(14-30-23)19-4-3-18(15-27-19)24(6-1-7-24)22-31-21(34-32-22)16-2-5-20(28-12-16)33-10-8-26-9-11-33/h2-5,12-15,26H,1,6-11H2,(H2,25,29,30)
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n/an/a 2.70n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104553
PNG
(US8575201, 44)
Show SMILES C[C@@H](O)CNc1ccc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1 |r|
Show InChI InChI=1S/C23H24N8O2/c1-14(32)9-26-19-6-3-15(10-27-19)20-30-21(31-33-20)23(7-2-8-23)17-4-5-18(25-13-17)16-11-28-22(24)29-12-16/h3-6,10-14,32H,2,7-9H2,1H3,(H,26,27)(H2,24,28,29)/t14-/m1/s1
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n/an/a 2.70n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104598
PNG
(US8575201, 89)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1ccc(nc1)N1CCOCC1
Show InChI InChI=1S/C24H24N8O2/c25-23-28-13-17(14-29-23)19-4-3-18(15-26-19)24(6-1-7-24)22-30-21(34-31-22)16-2-5-20(27-12-16)32-8-10-33-11-9-32/h2-5,12-15H,1,6-11H2,(H2,25,28,29)
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n/an/a 2.70n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104559
PNG
(US8575201, 50)
Show SMILES CS(=O)(=O)N1CCN(CC1)c1ccc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C25H27N9O3S/c1-38(35,36)34-11-9-33(10-12-34)21-6-3-17(13-28-21)22-31-23(32-37-22)25(7-2-8-25)19-4-5-20(27-16-19)18-14-29-24(26)30-15-18/h3-6,13-16H,2,7-12H2,1H3,(H2,26,29,30)
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n/an/a 2.70n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104627
PNG
(US8575201, 118)
Show SMILES COCCNc1ccc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C23H24N8O2/c1-32-10-9-25-19-6-3-15(11-27-19)20-30-21(31-33-20)23(7-2-8-23)17-4-5-18(26-14-17)16-12-28-22(24)29-13-16/h3-6,11-14H,2,7-10H2,1H3,(H,25,27)(H2,24,28,29)
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n/an/a 2.80n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104541
PNG
(US8575201, 32)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1ccc(O)cc1
Show InChI InChI=1S/C21H18N6O2/c22-20-24-10-14(11-25-20)17-7-4-15(12-23-17)21(8-1-9-21)19-26-18(29-27-19)13-2-5-16(28)6-3-13/h2-7,10-12,28H,1,8-9H2,(H2,22,24,25)
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n/an/a 2.90n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104518
PNG
(US8575201, 9)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1ccc(NC2CC2)nc1
Show InChI InChI=1S/C23H22N8O/c24-22-27-11-15(12-28-22)18-6-3-16(13-25-18)23(8-1-9-23)21-30-20(32-31-21)14-2-7-19(26-10-14)29-17-4-5-17/h2-3,6-7,10-13,17H,1,4-5,8-9H2,(H,26,29)(H2,24,27,28)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104626
PNG
(US8575201, 117)
Show SMILES COCCN(C)c1ccc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C24H26N8O2/c1-32(10-11-33-2)20-7-4-16(12-27-20)21-30-22(31-34-21)24(8-3-9-24)18-5-6-19(26-15-18)17-13-28-23(25)29-14-17/h4-7,12-15H,3,8-11H2,1-2H3,(H2,25,28,29)
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n/an/a 3n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104554
PNG
(US8575201, 45)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1ccc(nc1)N1CCC[C@@H]1CO |r|
Show InChI InChI=1S/C25H26N8O2/c26-24-29-12-17(13-30-24)20-6-5-18(14-27-20)25(8-2-9-25)23-31-22(35-32-23)16-4-7-21(28-11-16)33-10-1-3-19(33)15-34/h4-7,11-14,19,34H,1-3,8-10,15H2,(H2,26,29,30)/t19-/m1/s1
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n/an/a 3.10n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104565
PNG
(US8575201, 56)
Show SMILES COCCNc1cnc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C22H23N9O2/c1-32-8-7-24-18-13-26-17(12-27-18)19-30-20(31-33-19)22(5-2-6-22)15-3-4-16(25-11-15)14-9-28-21(23)29-10-14/h3-4,9-13H,2,5-8H2,1H3,(H,24,27)(H2,23,28,29)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104547
PNG
(US8575201, 38)
Show SMILES COC(=O)[C@H]1CNCCN1c1ccc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1 |r|
Show InChI InChI=1S/C26H27N9O3/c1-37-23(36)20-15-28-9-10-35(20)21-6-3-16(11-30-21)22-33-24(34-38-22)26(7-2-8-26)18-4-5-19(29-14-18)17-12-31-25(27)32-13-17/h3-6,11-14,20,28H,2,7-10,15H2,1H3,(H2,27,31,32)/t20-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104549
PNG
(US8575201, 40)
Show SMILES COC(=O)[C@H]1CN(CCN1)c1ccc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1 |r|
Show InChI InChI=1S/C26H27N9O3/c1-37-23(36)20-15-35(10-9-28-20)21-6-3-16(11-30-21)22-33-24(34-38-22)26(7-2-8-26)18-4-5-19(29-14-18)17-12-31-25(27)32-13-17/h3-6,11-14,20,28H,2,7-10,15H2,1H3,(H2,27,31,32)/t20-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104621
PNG
(US8575201, 112)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1ccc(nc1)N1CCCC1
Show InChI InChI=1S/C24H24N8O/c25-23-28-13-17(14-29-23)19-6-5-18(15-26-19)24(8-3-9-24)22-30-21(33-31-22)16-4-7-20(27-12-16)32-10-1-2-11-32/h4-7,12-15H,1-3,8-11H2,(H2,25,28,29)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104556
PNG
(US8575201, 47)
Show SMILES CCOC(=O)CCN1CCN(CC1)c1ccc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C29H33N9O3/c1-2-40-25(39)8-11-37-12-14-38(15-13-37)24-7-4-20(16-32-24)26-35-27(36-41-26)29(9-3-10-29)22-5-6-23(31-19-22)21-17-33-28(30)34-18-21/h4-7,16-19H,2-3,8-15H2,1H3,(H2,30,33,34)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104548
PNG
(US8575201, 39)
Show SMILES COC(=O)[C@@H]1CN(CCN1)c1ccc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1 |r|
Show InChI InChI=1S/C26H27N9O3/c1-37-23(36)20-15-35(10-9-28-20)21-6-3-16(11-30-21)22-33-24(34-38-22)26(7-2-8-26)18-4-5-19(29-14-18)17-12-31-25(27)32-13-17/h3-6,11-14,20,28H,2,7-10,15H2,1H3,(H2,27,31,32)/t20-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104558
PNG
(US8575201, 49)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1ccc(nc1)N1CCS(=O)(=O)CC1
Show InChI InChI=1S/C24H24N8O3S/c25-23-28-13-17(14-29-23)19-4-3-18(15-26-19)24(6-1-7-24)22-30-21(35-31-22)16-2-5-20(27-12-16)32-8-10-36(33,34)11-9-32/h2-5,12-15H,1,6-11H2,(H2,25,28,29)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104687
PNG
(US8575201, 1)
Show SMILES CC(C)(C)CC(=O)N1CCN(CC1)c1ccc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C30H35N9O2/c1-29(2,3)15-25(40)39-13-11-38(12-14-39)24-8-5-20(16-33-24)26-36-27(37-41-26)30(9-4-10-30)22-6-7-23(32-19-22)21-17-34-28(31)35-18-21/h5-8,16-19H,4,9-15H2,1-3H3,(H2,31,34,35)
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n/an/a 3.80n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104522
PNG
(US8575201, 13)
Show SMILES CCOC(=O)CNc1ccc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C24H24N8O3/c1-2-34-20(33)14-28-19-7-4-15(10-27-19)21-31-22(32-35-21)24(8-3-9-24)17-5-6-18(26-13-17)16-11-29-23(25)30-12-16/h4-7,10-13H,2-3,8-9,14H2,1H3,(H,27,28)(H2,25,29,30)
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n/an/a 3.90n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104534
PNG
(US8575201, 25)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1cnn2cccnc12
Show InChI InChI=1S/C21H17N9O/c22-20-25-9-13(10-26-20)16-4-3-14(11-24-16)21(5-1-6-21)19-28-18(31-29-19)15-12-27-30-8-2-7-23-17(15)30/h2-4,7-12H,1,5-6H2,(H2,22,25,26)
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n/an/a 4n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104588
PNG
(US8575201, 79)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C22H18N8O/c23-21-25-9-15(10-26-21)17-5-3-16(12-24-17)22(6-1-7-22)20-28-19(31-30-20)13-2-4-18-14(8-13)11-27-29-18/h2-5,8-12H,1,6-7H2,(H,27,29)(H2,23,25,26)
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n/an/a 4n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104593
PNG
(US8575201, 84)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1cccnc1Cl
Show InChI InChI=1S/C20H16ClN7O/c21-16-14(3-1-8-23-16)17-27-18(28-29-17)20(6-2-7-20)13-4-5-15(24-11-13)12-9-25-19(22)26-10-12/h1,3-5,8-11H,2,6-7H2,(H2,22,25,26)
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n/an/a 4.10n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104620
PNG
(US8575201, 111)
Show SMILES Nc1ccc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C20H18N8O/c21-16-5-2-12(8-24-16)17-27-18(28-29-17)20(6-1-7-20)14-3-4-15(23-11-14)13-9-25-19(22)26-10-13/h2-5,8-11H,1,6-7H2,(H2,21,24)(H2,22,25,26)
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n/an/a 4.20n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104625
PNG
(US8575201, 116)
Show SMILES CN(CCO)c1ccc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C23H24N8O2/c1-31(9-10-32)19-6-3-15(11-26-19)20-29-21(30-33-20)23(7-2-8-23)17-4-5-18(25-14-17)16-12-27-22(24)28-13-16/h3-6,11-14,32H,2,7-10H2,1H3,(H2,24,27,28)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104583
PNG
(US8575201, 74)
Show SMILES Cc1ccc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C21H19N7O/c1-13-3-4-14(9-23-13)18-27-19(28-29-18)21(7-2-8-21)16-5-6-17(24-12-16)15-10-25-20(22)26-11-15/h3-6,9-12H,2,7-8H2,1H3,(H2,22,25,26)
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n/an/a 4.5n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM41570
PNG
(US8575201, 135 | US8575201, 78)
Show SMILES Cc1n[nH]cc1-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C24H23N5O2/c1-17-13-22(27-31-17)24(30)29-10-4-9-28(11-12-29)23-15-21(25-16-26-23)20-8-7-18-5-2-3-6-19(18)14-20/h2-3,5-8,13-16H,4,9-12H2,1H3
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n/an/a 4.70n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104560
PNG
(US8575201, 51)
Show SMILES CS(=O)(=O)CCNc1ccc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C23H24N8O3S/c1-35(32,33)10-9-25-19-6-3-15(11-27-19)20-30-21(31-34-20)23(7-2-8-23)17-4-5-18(26-14-17)16-12-28-22(24)29-13-16/h3-6,11-14H,2,7-10H2,1H3,(H,25,27)(H2,24,28,29)
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n/an/a 4.80n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104511
PNG
(US8575201, 2)
Show SMILES NC(=O)CNc1ccc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C22H21N9O2/c23-17(32)12-27-18-5-2-13(8-26-18)19-30-20(31-33-19)22(6-1-7-22)15-3-4-16(25-11-15)14-9-28-21(24)29-10-14/h2-5,8-11H,1,6-7,12H2,(H2,23,32)(H,26,27)(H2,24,28,29)
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n/an/a 5n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104589
PNG
(US8575201, 80)
Show SMILES Cc1cc([nH]n1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C19H18N8O/c1-11-7-15(26-25-11)16-24-17(27-28-16)19(5-2-6-19)13-3-4-14(21-10-13)12-8-22-18(20)23-9-12/h3-4,7-10H,2,5-6H2,1H3,(H,25,26)(H2,20,22,23)
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n/an/a 5.5n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104515
PNG
(US8575201, 6)
Show SMILES Cc1ccc(cc1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C22H20N6O/c1-14-3-5-15(6-4-14)19-27-20(28-29-19)22(9-2-10-22)17-7-8-18(24-13-17)16-11-25-21(23)26-12-16/h3-8,11-13H,2,9-10H2,1H3,(H2,23,25,26)
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n/an/a 5.80n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104545
PNG
(US8575201, 36)
Show SMILES COC(=O)[C@@H]1CCCN1c1ccc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1 |r|
Show InChI InChI=1S/C26H26N8O3/c1-36-23(35)20-4-2-11-34(20)21-8-5-16(12-29-21)22-32-24(33-37-22)26(9-3-10-26)18-6-7-19(28-15-18)17-13-30-25(27)31-14-17/h5-8,12-15,20H,2-4,9-11H2,1H3,(H2,27,30,31)/t20-/m0/s1
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n/an/a 5.90n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104577
PNG
(US8575201, 68)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1cnn(CC(F)F)c1
Show InChI InChI=1S/C20H18F2N8O/c21-16(22)11-30-10-13(8-27-30)17-28-18(29-31-17)20(4-1-5-20)14-2-3-15(24-9-14)12-6-25-19(23)26-7-12/h2-3,6-10,16H,1,4-5,11H2,(H2,23,25,26)
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n/an/a 6.10n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104599
PNG
(US8575201, 90)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1cn[nH]c1
Show InChI InChI=1S/C18H16N8O/c19-17-21-6-11(7-22-17)14-3-2-13(10-20-14)18(4-1-5-18)16-25-15(27-26-16)12-8-23-24-9-12/h2-3,6-10H,1,4-5H2,(H,23,24)(H2,19,21,22)
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n/an/a 7n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104573
PNG
(US8575201, 64)
Show SMILES CC(C)n1cc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C21H22N8O/c1-13(2)29-12-15(10-26-29)18-27-19(28-30-18)21(6-3-7-21)16-4-5-17(23-11-16)14-8-24-20(22)25-9-14/h4-5,8-13H,3,6-7H2,1-2H3,(H2,22,24,25)
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n/an/a 7.20n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104597
PNG
(US8575201, 88)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1cnccc1Cl
Show InChI InChI=1S/C20H16ClN7O/c21-15-4-7-23-11-14(15)17-27-18(28-29-17)20(5-1-6-20)13-2-3-16(24-10-13)12-8-25-19(22)26-9-12/h2-4,7-11H,1,5-6H2,(H2,22,25,26)
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n/an/a 7.30n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104605
PNG
(US8575201, 96)
Show SMILES COc1ccc(-c2nc(no2)C2(CCC2)c2ccc(nc2)-c2cnc(N)nc2)c(OC)n1
Show InChI InChI=1S/C22H21N7O3/c1-30-17-7-5-15(18(27-17)31-2)19-28-20(29-32-19)22(8-3-9-22)14-4-6-16(24-12-14)13-10-25-21(23)26-11-13/h4-7,10-12H,3,8-9H2,1-2H3,(H2,23,25,26)
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n/an/a 7.30n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104575
PNG
(US8575201, 66)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1cnn(c1)C(F)F
Show InChI InChI=1S/C19H16F2N8O/c20-17(21)29-10-12(8-26-29)15-27-16(28-30-15)19(4-1-5-19)13-2-3-14(23-9-13)11-6-24-18(22)25-7-11/h2-3,6-10,17H,1,4-5H2,(H2,22,24,25)
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n/an/a 7.40n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104608
PNG
(US8575201, 99)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1ccc(Cl)nc1
Show InChI InChI=1S/C20H16ClN7O/c21-16-5-2-12(8-24-16)17-27-18(28-29-17)20(6-1-7-20)14-3-4-15(23-11-14)13-9-25-19(22)26-10-13/h2-5,8-11H,1,6-7H2,(H2,22,25,26)
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n/an/a 7.5n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104578
PNG
(US8575201, 69)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1cnn(CC(F)(F)F)c1
Show InChI InChI=1S/C20H17F3N8O/c21-20(22,23)11-31-10-13(8-28-31)16-29-17(30-32-16)19(4-1-5-19)14-2-3-15(25-9-14)12-6-26-18(24)27-7-12/h2-3,6-10H,1,4-5,11H2,(H2,24,26,27)
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n/an/a 7.60n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104551
PNG
(US8575201, 42)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1ccc(nc1)N1CCN[C@H](C1)C(O)=O |r|
Show InChI InChI=1S/C25H25N9O3/c26-24-30-11-16(12-31-24)18-4-3-17(13-28-18)25(6-1-7-25)23-32-21(37-33-23)15-2-5-20(29-10-15)34-9-8-27-19(14-34)22(35)36/h2-5,10-13,19,27H,1,6-9,14H2,(H,35,36)(H2,26,30,31)/t19-/m1/s1
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n/an/a 7.70n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104550
PNG
(US8575201, 41)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1ccc(nc1)N1CCN[C@@H](C1)C(O)=O |r|
Show InChI InChI=1S/C25H25N9O3/c26-24-30-11-16(12-31-24)18-4-3-17(13-28-18)25(6-1-7-25)23-32-21(37-33-23)15-2-5-20(29-10-15)34-9-8-27-19(14-34)22(35)36/h2-5,10-13,19,27H,1,6-9,14H2,(H,35,36)(H2,26,30,31)/t19-/m0/s1
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n/an/a 7.70n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104569
PNG
(US8575201, 60)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1cnc(cn1)N1CCNCC1
Show InChI InChI=1S/C23H24N10O/c24-22-29-10-15(11-30-22)17-3-2-16(12-26-17)23(4-1-5-23)21-31-20(34-32-21)18-13-28-19(14-27-18)33-8-6-25-7-9-33/h2-3,10-14,25H,1,4-9H2,(H2,24,29,30)
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n/an/a 7.90n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104603
PNG
(US8575201, 94)
Show SMILES Cc1nc(C)c(s1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C20H19N7OS/c1-11-16(29-12(2)25-11)17-26-18(27-28-17)20(6-3-7-20)14-4-5-15(22-10-14)13-8-23-19(21)24-9-13/h4-5,8-10H,3,6-7H2,1-2H3,(H2,21,23,24)
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n/an/a 8.10n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104654
PNG
(US8575201, 145)
Show SMILES Nc1cnc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1cnn(c1)C1COC1
Show InChI InChI=1S/C21H20N8O2/c22-18-9-24-17(8-25-18)16-3-2-14(7-23-16)21(4-1-5-21)20-27-19(31-28-20)13-6-26-29(10-13)15-11-30-12-15/h2-3,6-10,15H,1,4-5,11-12H2,(H2,22,25)
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n/an/a 8.30n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104526
PNG
(US8575201, 17)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C21H19N7O3S/c22-20-25-10-14(11-26-20)17-7-4-15(12-24-17)21(8-1-9-21)19-27-18(31-28-19)13-2-5-16(6-3-13)32(23,29)30/h2-7,10-12H,1,8-9H2,(H2,22,25,26)(H2,23,29,30)
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n/an/a 8.70n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104572
PNG
(US8575201, 63)
Show SMILES CCn1cc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C20H20N8O/c1-2-28-12-14(10-25-28)17-26-18(27-29-17)20(6-3-7-20)15-4-5-16(22-11-15)13-8-23-19(21)24-9-13/h4-5,8-12H,2-3,6-7H2,1H3,(H2,21,23,24)
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n/an/a 8.80n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104514
PNG
(US8575201, 5)
Show SMILES Cc1cccc(c1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C22H20N6O/c1-14-4-2-5-15(10-14)19-27-20(28-29-19)22(8-3-9-22)17-6-7-18(24-13-17)16-11-25-21(23)26-12-16/h2,4-7,10-13H,3,8-9H2,1H3,(H2,23,25,26)
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n/an/a 8.80n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104529
PNG
(US8575201, 20)
Show SMILES Cn1cc(-c2nc(no2)C2(CCC2)c2ccc(nc2)-c2cnc(N)nc2)c(n1)C(F)(F)F
Show InChI InChI=1S/C20H17F3N8O/c1-31-10-13(15(29-31)20(21,22)23)16-28-17(30-32-16)19(5-2-6-19)12-3-4-14(25-9-12)11-7-26-18(24)27-8-11/h3-4,7-10H,2,5-6H2,1H3,(H2,24,26,27)
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n/an/a 9.20n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104576
PNG
(US8575201, 67)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1cnn(CCF)c1
Show InChI InChI=1S/C20H19FN8O/c21-6-7-29-12-14(10-26-29)17-27-18(28-30-17)20(4-1-5-20)15-2-3-16(23-11-15)13-8-24-19(22)25-9-13/h2-3,8-12H,1,4-7H2,(H2,22,24,25)
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n/an/a 9.5n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104602
PNG
(US8575201, 93)
Show SMILES COc1cc(ccn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C21H19N7O2/c1-29-17-9-13(5-8-23-17)18-27-19(28-30-18)21(6-2-7-21)15-3-4-16(24-12-15)14-10-25-20(22)26-11-14/h3-5,8-12H,2,6-7H2,1H3,(H2,22,25,26)
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n/an/a 9.60n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104516
PNG
(US8575201, 7)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C22H20N6O3S/c1-32(29,30)17-6-3-14(4-7-17)19-27-20(28-31-19)22(9-2-10-22)16-5-8-18(24-13-16)15-11-25-21(23)26-12-15/h3-8,11-13H,2,9-10H2,1H3,(H2,23,25,26)
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n/an/a 11n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104633
PNG
(US8575201, 124)
Show SMILES Cn1nccc1-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C19H18N8O/c1-27-15(5-8-24-27)16-25-17(26-28-16)19(6-2-7-19)13-3-4-14(21-11-13)12-9-22-18(20)23-10-12/h3-5,8-11H,2,6-7H2,1H3,(H2,20,22,23)
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n/an/a 11n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104525
PNG
(US8575201, 16)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1ccc(NCC(O)=O)nc1
Show InChI InChI=1S/C22H20N8O3/c23-21-27-9-14(10-28-21)16-4-3-15(11-24-16)22(6-1-7-22)20-29-19(33-30-20)13-2-5-17(25-8-13)26-12-18(31)32/h2-5,8-11H,1,6-7,12H2,(H,25,26)(H,31,32)(H2,23,27,28)
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n/an/a 11n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104650
PNG
(US8575201, 141)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1cnn(CC#N)c1
Show InChI InChI=1S/C20H17N9O/c21-6-7-29-12-14(10-26-29)17-27-18(28-30-17)20(4-1-5-20)15-2-3-16(23-11-15)13-8-24-19(22)25-9-13/h2-3,8-12H,1,4-5,7H2,(H2,22,24,25)
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n/an/a 11n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104536
PNG
(US8575201, 27)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1ccc2nccn2c1
Show InChI InChI=1S/C22H18N8O/c23-21-26-10-15(11-27-21)17-4-3-16(12-25-17)22(6-1-7-22)20-28-19(31-29-20)14-2-5-18-24-8-9-30(18)13-14/h2-5,8-13H,1,6-7H2,(H2,23,26,27)
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n/an/a 12.4n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104661
PNG
(US8575201, 152)
Show SMILES Nc1ccc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1cnn(c1)C1COC1
Show InChI InChI=1S/C22H21N7O2/c23-19-5-2-14(8-25-19)18-4-3-16(10-24-18)22(6-1-7-22)21-27-20(31-28-21)15-9-26-29(11-15)17-12-30-13-17/h2-5,8-11,17H,1,6-7,12-13H2,(H2,23,25)
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n/an/a 13n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104564
PNG
(US8575201, 55)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1cnn(c1)C1COC1
Show InChI InChI=1S/C21H20N8O2/c22-20-24-6-13(7-25-20)17-3-2-15(9-23-17)21(4-1-5-21)19-27-18(31-28-19)14-8-26-29(10-14)16-11-30-12-16/h2-3,6-10,16H,1,4-5,11-12H2,(H2,22,24,25)
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n/an/a 13n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104611
PNG
(US8575201, 102)
Show SMILES Cn1cc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C19H18N8O/c1-27-11-13(9-24-27)16-25-17(26-28-16)19(5-2-6-19)14-3-4-15(21-10-14)12-7-22-18(20)23-8-12/h3-4,7-11H,2,5-6H2,1H3,(H2,20,22,23)
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n/an/a 13n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104612
PNG
(US8575201, 103)
Show SMILES Cc1n[nH]c(C)c1-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C20H20N8O/c1-11-16(12(2)27-26-11)17-25-18(28-29-17)20(6-3-7-20)14-4-5-15(22-10-14)13-8-23-19(21)24-9-13/h4-5,8-10H,3,6-7H2,1-2H3,(H,26,27)(H2,21,23,24)
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n/an/a 14n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104653
PNG
(US8575201, 144)
Show SMILES CC(C)(C)NC(=O)Cn1cc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C24H27N9O2/c1-23(2,3)31-19(34)14-33-13-16(11-29-33)20-30-21(32-35-20)24(7-4-8-24)17-5-6-18(26-12-17)15-9-27-22(25)28-10-15/h5-6,9-13H,4,7-8,14H2,1-3H3,(H,31,34)(H2,25,27,28)
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n/an/a 14n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104618
PNG
(US8575201, 109)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1cccnc1C(F)(F)F
Show InChI InChI=1S/C21H16F3N7O/c22-21(23,24)16-14(3-1-8-26-16)17-30-18(31-32-17)20(6-2-7-20)13-4-5-15(27-11-13)12-9-28-19(25)29-10-12/h1,3-5,8-11H,2,6-7H2,(H2,25,28,29)
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n/an/a 14n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104652
PNG
(US8575201, 143)
Show SMILES CN(C(=O)Cn1cc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1)C(C)(C)C
Show InChI InChI=1S/C25H29N9O2/c1-24(2,3)33(4)20(35)15-34-14-17(12-30-34)21-31-22(32-36-21)25(8-5-9-25)18-6-7-19(27-13-18)16-10-28-23(26)29-11-16/h6-7,10-14H,5,8-9,15H2,1-4H3,(H2,26,28,29)
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n/an/a 14n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104649
PNG
(US8575201, 140)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1cnn(CCN2CCOCC2)c1
Show InChI InChI=1S/C24H27N9O2/c25-23-27-12-17(13-28-23)20-3-2-19(15-26-20)24(4-1-5-24)22-30-21(35-31-22)18-14-29-33(16-18)7-6-32-8-10-34-11-9-32/h2-3,12-16H,1,4-11H2,(H2,25,27,28)
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n/an/a 15n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104655
PNG
(US8575201, 146)
Show SMILES CC(C)(O)Cn1cc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)cn1
Show InChI InChI=1S/C22H24N8O2/c1-21(2,31)13-30-12-14(8-27-30)19-28-20(29-32-19)22(6-3-7-22)15-4-5-16(24-9-15)17-10-26-18(23)11-25-17/h4-5,8-12,31H,3,6-7,13H2,1-2H3,(H2,23,26)
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n/an/a 15n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104651
PNG
(US8575201, 142)
Show SMILES CN(C)CCn1cc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C22H25N9O/c1-30(2)8-9-31-14-16(12-27-31)19-28-20(29-32-19)22(6-3-7-22)17-4-5-18(24-13-17)15-10-25-21(23)26-11-15/h4-5,10-14H,3,6-9H2,1-2H3,(H2,23,25,26)
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n/an/a 16n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104591
PNG
(US8575201, 82)
Show SMILES CC(C)(O)c1ccc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C23H23N7O2/c1-22(2,31)18-7-4-14(10-26-18)19-29-20(30-32-19)23(8-3-9-23)16-5-6-17(25-13-16)15-11-27-21(24)28-12-15/h4-7,10-13,31H,3,8-9H2,1-2H3,(H2,24,27,28)
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n/an/a 17n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104513
PNG
(US8575201, 4)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1cc[nH]n1
Show InChI InChI=1S/C18H16N8O/c19-17-21-8-11(9-22-17)13-3-2-12(10-20-13)18(5-1-6-18)16-24-15(27-26-16)14-4-7-23-25-14/h2-4,7-10H,1,5-6H2,(H,23,25)(H2,19,21,22)
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n/an/a 17n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104537
PNG
(US8575201, 28)
Show SMILES COCCn1cc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C21H22N8O2/c1-30-8-7-29-13-15(11-26-29)18-27-19(28-31-18)21(5-2-6-21)16-3-4-17(23-12-16)14-9-24-20(22)25-10-14/h3-4,9-13H,2,5-8H2,1H3,(H2,22,24,25)
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n/an/a 17n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104614
PNG
(US8575201, 105)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1cccnc1N
Show InChI InChI=1S/C20H18N8O/c21-16-14(3-1-8-23-16)17-27-18(28-29-17)20(6-2-7-20)13-4-5-15(24-11-13)12-9-25-19(22)26-10-12/h1,3-5,8-11H,2,6-7H2,(H2,21,23)(H2,22,25,26)
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n/an/a 17n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104660
PNG
(US8575201, 151)
Show SMILES CC(C)(C#N)n1cc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C22H21N9O/c1-21(2,13-23)31-12-15(10-28-31)18-29-19(30-32-18)22(6-3-7-22)16-4-5-17(25-11-16)14-8-26-20(24)27-9-14/h4-5,8-12H,3,6-7H2,1-2H3,(H2,24,26,27)
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n/an/a 18n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104595
PNG
(US8575201, 86)
Show SMILES COc1ccncc1-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C21H19N7O2/c1-29-17-5-8-23-12-15(17)18-27-19(28-30-18)21(6-2-7-21)14-3-4-16(24-11-14)13-9-25-20(22)26-10-13/h3-5,8-12H,2,6-7H2,1H3,(H2,22,25,26)
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n/an/a 18n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104606
PNG
(US8575201, 97)
Show SMILES Cc1ccc(-c2nc(no2)C2(CCC2)c2ccc(nc2)-c2cnc(N)nc2)c(=O)[nH]1
Show InChI InChI=1S/C21H19N7O2/c1-12-3-5-15(17(29)26-12)18-27-19(28-30-18)21(7-2-8-21)14-4-6-16(23-11-14)13-9-24-20(22)25-10-13/h3-6,9-11H,2,7-8H2,1H3,(H,26,29)(H2,22,24,25)
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n/an/a 19n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104584
PNG
(US8575201, 75)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1c[nH]cn1
Show InChI InChI=1S/C18H16N8O/c19-17-22-6-11(7-23-17)13-3-2-12(8-21-13)18(4-1-5-18)16-25-15(27-26-16)14-9-20-10-24-14/h2-3,6-10H,1,4-5H2,(H,20,24)(H2,19,22,23)
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n/an/a 19n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104594
PNG
(US8575201, 85)
Show SMILES Cc1ncccc1-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C21H19N7O/c1-13-16(4-2-9-23-13)18-27-19(28-29-18)21(7-3-8-21)15-5-6-17(24-12-15)14-10-25-20(22)26-11-14/h2,4-6,9-12H,3,7-8H2,1H3,(H2,22,25,26)
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n/an/a 21n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104567
PNG
(US8575201, 58)
Show SMILES CNC(=O)Cn1cc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C21H21N9O2/c1-23-17(31)12-30-11-14(9-27-30)18-28-19(29-32-18)21(5-2-6-21)15-3-4-16(24-10-15)13-7-25-20(22)26-8-13/h3-4,7-11H,2,5-6,12H2,1H3,(H,23,31)(H2,22,25,26)
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n/an/a 22n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104685
PNG
(US8575201, 176)
Show SMILES CNc1cnc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1cnn(c1)C1COC1
Show InChI InChI=1S/C22H22N8O2/c1-23-19-10-25-18(9-26-19)17-4-3-15(8-24-17)22(5-2-6-22)21-28-20(32-29-21)14-7-27-30(11-14)16-12-31-13-16/h3-4,7-11,16H,2,5-6,12-13H2,1H3,(H,23,26)
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n/an/a 23n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104600
PNG
(US8575201, 91)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1cc[nH]c(=O)c1
Show InChI InChI=1S/C20H17N7O2/c21-19-24-9-13(10-25-19)15-3-2-14(11-23-15)20(5-1-6-20)18-26-17(29-27-18)12-4-7-22-16(28)8-12/h2-4,7-11H,1,5-6H2,(H,22,28)(H2,21,24,25)
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n/an/a 24n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104610
PNG
(US8575201, 101)
Show SMILES Cc1cc(ccn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C21H19N7O/c1-13-9-14(5-8-23-13)18-27-19(28-29-18)21(6-2-7-21)16-3-4-17(24-12-16)15-10-25-20(22)26-11-15/h3-5,8-12H,2,6-7H2,1H3,(H2,22,25,26)
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n/an/a 24n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104590
PNG
(US8575201, 81)
Show SMILES COC(=O)c1ccc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C22H19N7O3/c1-31-19(30)17-5-3-13(9-24-17)18-28-20(29-32-18)22(7-2-8-22)15-4-6-16(25-12-15)14-10-26-21(23)27-11-14/h3-6,9-12H,2,7-8H2,1H3,(H2,23,26,27)
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n/an/a 25n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM41569
PNG
(US8575201, 148)
Show SMILES CC(C)(Cn1cc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1)C#N
Show InChI InChI=1S/C21H22FN5O2/c1-14-4-5-16(22)11-17(14)18-12-20(24-13-23-18)26-6-3-7-27(9-8-26)21(28)19-10-15(2)29-25-19/h4-5,10-13H,3,6-9H2,1-2H3
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n/an/a 25n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104582
PNG
(US8575201, 73)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1cccnc1
Show InChI InChI=1S/C20H17N7O/c21-19-24-10-14(11-25-19)16-5-4-15(12-23-16)20(6-2-7-20)18-26-17(28-27-18)13-3-1-8-22-9-13/h1,3-5,8-12H,2,6-7H2,(H2,21,24,25)
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n/an/a 25n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104639
PNG
(US8575201, 130)
Show SMILES Cc1cnc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C20H18N8O/c1-12-7-23-16(11-22-12)17-27-18(28-29-17)20(5-2-6-20)14-3-4-15(24-10-14)13-8-25-19(21)26-9-13/h3-4,7-11H,2,5-6H2,1H3,(H2,21,25,26)
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n/an/a 26n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104532
PNG
(US8575201, 23)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1cscn1
Show InChI InChI=1S/C18H15N7OS/c19-17-21-6-11(7-22-17)13-3-2-12(8-20-13)18(4-1-5-18)16-24-15(26-25-16)14-9-27-10-23-14/h2-3,6-10H,1,4-5H2,(H2,19,21,22)
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n/an/a 26n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM41570
PNG
(US8575201, 135 | US8575201, 78)
Show SMILES Cc1n[nH]cc1-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C24H23N5O2/c1-17-13-22(27-31-17)24(30)29-10-4-9-28(11-12-29)23-15-21(25-16-26-23)20-8-7-18-5-2-3-6-19(18)14-20/h2-3,5-8,13-16H,4,9-12H2,1H3
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n/an/a 27n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM41570
PNG
(US8575201, 135 | US8575201, 78)
Show SMILES Cc1n[nH]cc1-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C24H23N5O2/c1-17-13-22(27-31-17)24(30)29-10-4-9-28(11-12-29)23-15-21(25-16-26-23)20-8-7-18-5-2-3-6-19(18)14-20/h2-3,5-8,13-16H,4,9-12H2,1H3
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n/an/a 27n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104563
PNG
(US8575201, 54)
Show SMILES CC(C)(O)Cn1cc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C22H24N8O2/c1-21(2,31)13-30-12-15(10-27-30)18-28-19(29-32-18)22(6-3-7-22)16-4-5-17(24-11-16)14-8-25-20(23)26-9-14/h4-5,8-12,31H,3,6-7,13H2,1-2H3,(H2,23,25,26)
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n/an/a 28n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104630
PNG
(US8575201, 121)
Show SMILES Cc1cc(-c2nc(no2)C2(CCC2)c2ccc(nc2)-c2cnc(N)nc2)n(C)n1
Show InChI InChI=1S/C20H20N8O/c1-12-8-16(28(2)26-12)17-25-18(27-29-17)20(6-3-7-20)14-4-5-15(22-11-14)13-9-23-19(21)24-10-13/h4-5,8-11H,3,6-7H2,1-2H3,(H2,21,23,24)
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n/an/a 28n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104648
PNG
(US8575201, 139)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1cnn(c1)C1CCS(=O)(=O)C1
Show InChI InChI=1S/C22H22N8O3S/c23-21-25-8-14(9-26-21)18-3-2-16(11-24-18)22(5-1-6-22)20-28-19(33-29-20)15-10-27-30(12-15)17-4-7-34(31,32)13-17/h2-3,8-12,17H,1,4-7,13H2,(H2,23,25,26)
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n/an/a 28n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104631
PNG
(US8575201, 128)
Show SMILES CNc1ncccc1-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C21H20N8O/c1-23-17-15(4-2-9-24-17)18-28-19(29-30-18)21(7-3-8-21)14-5-6-16(25-12-14)13-10-26-20(22)27-11-13/h2,4-6,9-12H,3,7-8H2,1H3,(H,23,24)(H2,22,26,27)
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n/an/a 28n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104604
PNG
(US8575201, 95)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1ccc[nH]c1=O
Show InChI InChI=1S/C20H17N7O2/c21-19-24-9-12(10-25-19)15-5-4-13(11-23-15)20(6-2-7-20)18-26-17(29-27-18)14-3-1-8-22-16(14)28/h1,3-5,8-11H,2,6-7H2,(H,22,28)(H2,21,24,25)
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n/an/a 29n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104519
PNG
(US8575201, 10)
Show SMILES Nc1cc(n[nH]1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C18H17N9O/c19-14-6-13(25-26-14)15-24-16(27-28-15)18(4-1-5-18)11-2-3-12(21-9-11)10-7-22-17(20)23-8-10/h2-3,6-9H,1,4-5H2,(H3,19,25,26)(H2,20,22,23)
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n/an/a 30n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104615
PNG
(US8575201, 106)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1cnccc1N
Show InChI InChI=1S/C20H18N8O/c21-15-4-7-23-11-14(15)17-27-18(28-29-17)20(5-1-6-20)13-2-3-16(24-10-13)12-8-25-19(22)26-9-12/h2-4,7-11H,1,5-6H2,(H2,21,23)(H2,22,25,26)
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n/an/a 31n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104632
PNG
(US8575201, 123)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1cncs1
Show InChI InChI=1S/C18H15N7OS/c19-17-22-6-11(7-23-17)13-3-2-12(8-21-13)18(4-1-5-18)16-24-15(26-25-16)14-9-20-10-27-14/h2-3,6-10H,1,4-5H2,(H2,19,22,23)
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n/an/a 31n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104686
PNG
(US8575201, 177)
Show SMILES CNc1cnc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1cnn(CC(C)(C)O)c1
Show InChI InChI=1S/C23H26N8O2/c1-22(2,32)14-31-13-15(9-28-31)20-29-21(30-33-20)23(7-4-8-23)16-5-6-17(25-10-16)18-11-27-19(24-3)12-26-18/h5-6,9-13,32H,4,7-8,14H2,1-3H3,(H,24,27)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104539
PNG
(US8575201, 30)
Show SMILES CC(C)(CO)n1cc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C22H24N8O2/c1-21(2,13-31)30-12-15(10-27-30)18-28-19(29-32-18)22(6-3-7-22)16-4-5-17(24-11-16)14-8-25-20(23)26-9-14/h4-5,8-12,31H,3,6-7,13H2,1-2H3,(H2,23,25,26)
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n/an/a 33n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104677
PNG
(US8575201, 168)
Show SMILES CNc1cnc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1cnn(C)c1
Show InChI InChI=1S/C20H20N8O/c1-21-17-11-23-16(10-24-17)15-5-4-14(9-22-15)20(6-3-7-20)19-26-18(29-27-19)13-8-25-28(2)12-13/h4-5,8-12H,3,6-7H2,1-2H3,(H,21,24)
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n/an/a 33n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104635
PNG
(US8575201, 126)
Show SMILES CN(C)c1ncccc1-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C22H22N8O/c1-30(2)18-16(5-3-10-24-18)19-28-20(29-31-19)22(8-4-9-22)15-6-7-17(25-13-15)14-11-26-21(23)27-12-14/h3,5-7,10-13H,4,8-9H2,1-2H3,(H2,23,26,27)
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n/an/a 34n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104662
PNG
(US8575201, 153)
Show SMILES CC(C)(O)Cn1cc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1ccc(N)nc1
Show InChI InChI=1S/C23H25N7O2/c1-22(2,31)14-30-13-16(11-27-30)20-28-21(29-32-20)23(8-3-9-23)17-5-6-18(25-12-17)15-4-7-19(24)26-10-15/h4-7,10-13,31H,3,8-9,14H2,1-2H3,(H2,24,26)
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n/an/a 34n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104538
PNG
(US8575201, 29)
Show SMILES CC(CO)n1cc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C21H22N8O2/c1-13(12-30)29-11-15(9-26-29)18-27-19(28-31-18)21(5-2-6-21)16-3-4-17(23-10-16)14-7-24-20(22)25-8-14/h3-4,7-11,13,30H,2,5-6,12H2,1H3,(H2,22,24,25)
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n/an/a 35n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104683
PNG
(US8575201, 174)
Show SMILES Cn1cc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)cn1
Show InChI InChI=1S/C19H18N8O/c1-27-11-12(7-24-27)17-25-18(26-28-17)19(5-2-6-19)13-3-4-14(21-8-13)15-9-23-16(20)10-22-15/h3-4,7-11H,2,5-6H2,1H3,(H2,20,23)
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n/an/a 39n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104636
PNG
(US8575201, 127)
Show SMILES Cn1ccc(n1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C19H18N8O/c1-27-8-5-15(25-27)16-24-17(26-28-16)19(6-2-7-19)13-3-4-14(21-11-13)12-9-22-18(20)23-10-12/h3-5,8-11H,2,6-7H2,1H3,(H2,20,22,23)
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n/an/a 40n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104543
PNG
(US8575201, 34)
Show SMILES CN(C)C(=O)[C@@H]1CCCN1c1ccc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1 |r|
Show InChI InChI=1S/C27H29N9O2/c1-35(2)24(37)21-5-3-12-36(21)22-9-6-17(13-30-22)23-33-25(34-38-23)27(10-4-11-27)19-7-8-20(29-16-19)18-14-31-26(28)32-15-18/h6-9,13-16,21H,3-5,10-12H2,1-2H3,(H2,28,31,32)/t21-/m0/s1
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n/an/a 40n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104673
PNG
(US8575201, 164)
Show SMILES CN(C)C(=O)Cn1cc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)cn1
Show InChI InChI=1S/C22H23N9O2/c1-30(2)19(32)13-31-12-14(8-27-31)20-28-21(29-33-20)22(6-3-7-22)15-4-5-16(24-9-15)17-10-26-18(23)11-25-17/h4-5,8-12H,3,6-7,13H2,1-2H3,(H2,23,26)
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n/an/a 43n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104642
PNG
(US8575201, 133)
Show SMILES Cc1cc([nH]n1)-c1nc(no1)C1(CCC1)c1ccc(cn1)-c1cnc(N)nc1
Show InChI InChI=1S/C19H18N8O/c1-11-7-14(26-25-11)16-24-17(27-28-16)19(5-2-6-19)15-4-3-12(8-21-15)13-9-22-18(20)23-10-13/h3-4,7-10H,2,5-6H2,1H3,(H,25,26)(H2,20,22,23)
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n/an/a 43n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104544
PNG
(US8575201, 35)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1ccc(nc1)N1CCC[C@H]1C(O)=O |r|
Show InChI InChI=1S/C25H24N8O3/c26-24-29-12-16(13-30-24)18-6-5-17(14-27-18)25(8-2-9-25)23-31-21(36-32-23)15-4-7-20(28-11-15)33-10-1-3-19(33)22(34)35/h4-7,11-14,19H,1-3,8-10H2,(H,34,35)(H2,26,29,30)/t19-/m0/s1
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n/an/a 43n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104641
PNG
(US8575201, 132)
Show SMILES Nc1ncc(cn1)-c1ccc(nc1)C1(CCC1)c1noc(n1)-c1cn[nH]c1
Show InChI InChI=1S/C18H16N8O/c19-17-21-7-12(8-22-17)11-2-3-14(20-6-11)18(4-1-5-18)16-25-15(27-26-16)13-9-23-24-10-13/h2-3,6-10H,1,4-5H2,(H,23,24)(H2,19,21,22)
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n/an/a 46n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104638
PNG
(US8575201, 129)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1cnccn1
Show InChI InChI=1S/C19H16N8O/c20-18-24-8-12(9-25-18)14-3-2-13(10-23-14)19(4-1-5-19)17-26-16(28-27-17)15-11-21-6-7-22-15/h2-3,6-11H,1,4-5H2,(H2,20,24,25)
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n/an/a 47n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104679
PNG
(US8575201, 170)
Show SMILES Nc1cnc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1cnn(CC#N)c1
Show InChI InChI=1S/C20H17N9O/c21-6-7-29-12-13(8-26-29)18-27-19(28-30-18)20(4-1-5-20)14-2-3-15(23-9-14)16-10-25-17(22)11-24-16/h2-3,8-12H,1,4-5,7H2,(H2,22,25)
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n/an/a 48n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104617
PNG
(US8575201, 108)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1ccc(=O)[nH]c1
Show InChI InChI=1S/C20H17N7O2/c21-19-24-9-13(10-25-19)15-4-3-14(11-22-15)20(6-1-7-20)18-26-17(29-27-18)12-2-5-16(28)23-8-12/h2-5,8-11H,1,6-7H2,(H,23,28)(H2,21,24,25)
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n/an/a 48n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104680
PNG
(US8575201, 171)
Show SMILES COCCn1cc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)cn1
Show InChI InChI=1S/C21H22N8O2/c1-30-8-7-29-13-14(9-26-29)19-27-20(28-31-19)21(5-2-6-21)15-3-4-16(23-10-15)17-11-25-18(22)12-24-17/h3-4,9-13H,2,5-8H2,1H3,(H2,22,25)
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n/an/a 50n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104586
PNG
(US8575201, 77)
Show SMILES Cn1cccc(-c2nc(no2)C2(CCC2)c2ccc(nc2)-c2cnc(N)nc2)c1=O
Show InChI InChI=1S/C21H19N7O2/c1-28-9-2-4-15(18(28)29)17-26-19(27-30-17)21(7-3-8-21)14-5-6-16(23-12-14)13-10-24-20(22)25-11-13/h2,4-6,9-12H,3,7-8H2,1H3,(H2,22,24,25)
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n/an/a 51n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104640
PNG
(US8575201, 131)
Show SMILES Cn1cnc(c1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C19H18N8O/c1-27-10-15(24-11-27)16-25-17(26-28-16)19(5-2-6-19)13-3-4-14(21-9-13)12-7-22-18(20)23-8-12/h3-4,7-11H,2,5-6H2,1H3,(H2,20,22,23)
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n/an/a 52n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104592
PNG
(US8575201, 83)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1ccc(nc1)C#N
Show InChI InChI=1S/C21H16N8O/c22-8-16-4-2-13(9-24-16)18-28-19(29-30-18)21(6-1-7-21)15-3-5-17(25-12-15)14-10-26-20(23)27-11-14/h2-5,9-12H,1,6-7H2,(H2,23,26,27)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104596
PNG
(US8575201, 87)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1ccncc1
Show InChI InChI=1S/C20H17N7O/c21-19-24-10-14(11-25-19)16-3-2-15(12-23-16)20(6-1-7-20)18-26-17(28-27-18)13-4-8-22-9-5-13/h2-5,8-12H,1,6-7H2,(H2,21,24,25)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104580
PNG
(US8575201, 71)
Show SMILES CS(=O)(=O)Cn1cc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C20H20N8O3S/c1-32(29,30)12-28-11-14(9-25-28)17-26-18(27-31-17)20(5-2-6-20)15-3-4-16(22-10-15)13-7-23-19(21)24-8-13/h3-4,7-11H,2,5-6,12H2,1H3,(H2,21,23,24)
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n/an/a 58n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104528
PNG
(US8575201, 19)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1cccc(c1)S(N)(=O)=O
Show InChI InChI=1S/C21H19N7O3S/c22-20-25-10-14(11-26-20)17-6-5-15(12-24-17)21(7-2-8-21)19-27-18(31-28-19)13-3-1-4-16(9-13)32(23,29)30/h1,3-6,9-12H,2,7-8H2,(H2,22,25,26)(H2,23,29,30)
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n/an/a 58n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104628
PNG
(US8575201, 119)
Show SMILES CS(=O)(=O)c1ccc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C21H19N7O3S/c1-32(29,30)17-6-3-13(9-24-17)18-27-19(28-31-18)21(7-2-8-21)15-4-5-16(23-12-15)14-10-25-20(22)26-11-14/h3-6,9-12H,2,7-8H2,1H3,(H2,22,25,26)
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n/an/a 62n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104664
PNG
(US8575201, 155)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1cnn(CC(=O)NC2CC2)c1
Show InChI InChI=1S/C23H23N9O2/c24-22-26-8-14(9-27-22)18-5-2-16(11-25-18)23(6-1-7-23)21-30-20(34-31-21)15-10-28-32(12-15)13-19(33)29-17-3-4-17/h2,5,8-12,17H,1,3-4,6-7,13H2,(H,29,33)(H2,24,26,27)
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n/an/a 63n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104656
PNG
(US8575201, 147)
Show SMILES CC(C)(Cn1cc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1)C(N)=O
Show InChI InChI=1S/C23H25N9O2/c1-22(2,19(24)33)13-32-12-15(10-29-32)18-30-20(31-34-18)23(6-3-7-23)16-4-5-17(26-11-16)14-8-27-21(25)28-9-14/h4-5,8-12H,3,6-7,13H2,1-2H3,(H2,24,33)(H2,25,27,28)
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n/an/a 65n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104637
PNG
(US8575201, 128)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1cccnc1N1CCOCC1
Show InChI InChI=1S/C24H24N8O2/c25-23-28-13-16(14-29-23)19-5-4-17(15-27-19)24(6-2-7-24)22-30-21(34-31-22)18-3-1-8-26-20(18)32-9-11-33-12-10-32/h1,3-5,8,13-15H,2,6-7,9-12H2,(H2,25,28,29)
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n/an/a 66n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104659
PNG
(US8575201, 150)
Show SMILES CC(C)(N)Cn1cc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C22H25N9O/c1-21(2,24)13-31-12-15(10-28-31)18-29-19(30-32-18)22(6-3-7-22)16-4-5-17(25-11-16)14-8-26-20(23)27-9-14/h4-5,8-12H,3,6-7,13,24H2,1-2H3,(H2,23,26,27)
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n/an/a 68n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104674
PNG
(US8575201, 165)
Show SMILES CNc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1cnn(CC(C)(C)O)c1
Show InChI InChI=1S/C23H26N8O2/c1-22(2,32)14-31-13-16(11-28-31)19-29-20(30-33-19)23(7-4-8-23)17-5-6-18(25-12-17)15-9-26-21(24-3)27-10-15/h5-6,9-13,32H,4,7-8,14H2,1-3H3,(H,24,26,27)
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n/an/a 73n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104520
PNG
(US8575201, 11)
Show SMILES CS(=O)(=O)c1cccc(c1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C22H20N6O3S/c1-32(29,30)17-5-2-4-14(10-17)19-27-20(28-31-19)22(8-3-9-22)16-6-7-18(24-13-16)15-11-25-21(23)26-12-15/h2,4-7,10-13H,3,8-9H2,1H3,(H2,23,25,26)
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n/an/a 78n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104666
PNG
(US8575201, 157)
Show SMILES CC(C)NC(=O)Cn1cc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C23H25N9O2/c1-14(2)29-19(33)13-32-12-16(10-28-32)20-30-21(31-34-20)23(6-3-7-23)17-4-5-18(25-11-17)15-8-26-22(24)27-9-15/h4-5,8-12,14H,3,6-7,13H2,1-2H3,(H,29,33)(H2,24,26,27)
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n/an/a 79n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104643
PNG
(US8575201, 134)
Show SMILES Cn1cc(cn1)-c1nc(no1)C1(CCC1)c1ccc(cn1)-c1cnc(N)nc1
Show InChI InChI=1S/C19H18N8O/c1-27-11-14(10-24-27)16-25-17(26-28-16)19(5-2-6-19)15-4-3-12(7-21-15)13-8-22-18(20)23-9-13/h3-4,7-11H,2,5-6H2,1H3,(H2,20,22,23)
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n/an/a 81n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104568
PNG
(US8575201, 59)
Show SMILES CN(C)C(=O)Cn1cc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C22H23N9O2/c1-30(2)18(32)13-31-12-15(10-27-31)19-28-20(29-33-19)22(6-3-7-22)16-4-5-17(24-11-16)14-8-25-21(23)26-9-14/h4-5,8-12H,3,6-7,13H2,1-2H3,(H2,23,25,26)
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n/an/a 83n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104668
PNG
(US8575201, 159)
Show SMILES CN(CC1CCCO1)C(=O)Cn1cc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C26H29N9O3/c1-34(15-20-4-2-9-37-20)22(36)16-35-14-18(12-31-35)23-32-24(33-38-23)26(7-3-8-26)19-5-6-21(28-13-19)17-10-29-25(27)30-11-17/h5-6,10-14,20H,2-4,7-9,15-16H2,1H3,(H2,27,29,30)
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n/an/a 83n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104585
PNG
(US8575201, 76)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)N1CCCC1
Show InChI InChI=1S/C19H21N7O/c20-17-22-10-13(11-23-17)15-5-4-14(12-21-15)19(6-3-7-19)16-24-18(27-25-16)26-8-1-2-9-26/h4-5,10-12H,1-3,6-9H2,(H2,20,22,23)
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n/an/a 92n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104669
PNG
(US8575201, 160)
Show SMILES CN(C1CC1)C(=O)Cn1cc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C24H25N9O2/c1-32(18-4-5-18)20(34)14-33-13-16(11-29-33)21-30-22(31-35-21)24(7-2-8-24)17-3-6-19(26-12-17)15-9-27-23(25)28-10-15/h3,6,9-13,18H,2,4-5,7-8,14H2,1H3,(H2,25,27,28)
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n/an/a 95n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104665
PNG
(US8575201, 156)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1cnn(CC(=O)NCC2CCCO2)c1
Show InChI InChI=1S/C25H27N9O3/c26-24-29-9-16(10-30-24)20-5-4-18(12-27-20)25(6-2-7-25)23-32-22(37-33-23)17-11-31-34(14-17)15-21(35)28-13-19-3-1-8-36-19/h4-5,9-12,14,19H,1-3,6-8,13,15H2,(H,28,35)(H2,26,29,30)
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n/an/a 97n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104667
PNG
(US8575201, 158)
Show SMILES CCNC(=O)Cn1cc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C22H23N9O2/c1-2-24-18(32)13-31-12-15(10-28-31)19-29-20(30-33-19)22(6-3-7-22)16-4-5-17(25-11-16)14-8-26-21(23)27-9-14/h4-5,8-12H,2-3,6-7,13H2,1H3,(H,24,32)(H2,23,26,27)
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n/an/a 100n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104672
PNG
(US8575201, 163)
Show SMILES CN(C)C(=O)Cn1cc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1ccc(N)nc1
Show InChI InChI=1S/C23H24N8O2/c1-30(2)20(32)14-31-13-16(11-27-31)21-28-22(29-33-21)23(8-3-9-23)17-5-6-18(25-12-17)15-4-7-19(24)26-10-15/h4-7,10-13H,3,8-9,14H2,1-2H3,(H2,24,26)
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n/an/a 110n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104613
PNG
(US8575201, 104)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1ccnnc1
Show InChI InChI=1S/C19H16N8O/c20-18-22-8-13(9-23-18)15-3-2-14(11-21-15)19(5-1-6-19)17-26-16(28-27-17)12-4-7-24-25-10-12/h2-4,7-11H,1,5-6H2,(H2,20,22,23)
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n/an/a 110n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104533
PNG
(US8575201, 24)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1cocn1
Show InChI InChI=1S/C18H15N7O2/c19-17-21-6-11(7-22-17)13-3-2-12(8-20-13)18(4-1-5-18)16-24-15(27-25-16)14-9-26-10-23-14/h2-3,6-10H,1,4-5H2,(H2,19,21,22)
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n/an/a 110n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104546
PNG
(US8575201, 37)
Show SMILES Cn1cnnc1-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C18H17N9O/c1-27-10-23-25-14(27)15-24-16(26-28-15)18(5-2-6-18)12-3-4-13(20-9-12)11-7-21-17(19)22-8-11/h3-4,7-10H,2,5-6H2,1H3,(H2,19,21,22)
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n/an/a 110n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104535
PNG
(US8575201, 26)
Show SMILES Cn1cc(ccc1=O)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C21H19N7O2/c1-28-12-13(3-6-17(28)29)18-26-19(27-30-18)21(7-2-8-21)15-4-5-16(23-11-15)14-9-24-20(22)25-10-14/h3-6,9-12H,2,7-8H2,1H3,(H2,22,24,25)
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n/an/a 110n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104607
PNG
(US8575201, 98)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1cnco1
Show InChI InChI=1S/C18H15N7O2/c19-17-22-6-11(7-23-17)13-3-2-12(8-21-13)18(4-1-5-18)16-24-15(27-25-16)14-9-20-10-26-14/h2-3,6-10H,1,4-5H2,(H2,19,22,23)
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n/an/a 110n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104609
PNG
(US8575201, 100)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1cncnc1
Show InChI InChI=1S/C19H16N8O/c20-18-24-8-12(9-25-18)15-3-2-14(10-23-15)19(4-1-5-19)17-26-16(28-27-17)13-6-21-11-22-7-13/h2-3,6-11H,1,4-5H2,(H2,20,24,25)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104601
PNG
(US8575201, 92)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1ccncn1
Show InChI InChI=1S/C19H16N8O/c20-18-23-8-12(9-24-18)14-3-2-13(10-22-14)19(5-1-6-19)17-26-16(28-27-17)15-4-7-21-11-25-15/h2-4,7-11H,1,5-6H2,(H2,20,23,24)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104671
PNG
(US8575201, 162)
Show SMILES CCN(C)C(=O)Cn1cc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C23H25N9O2/c1-3-31(2)19(33)14-32-13-16(11-28-32)20-29-21(30-34-20)23(7-4-8-23)17-5-6-18(25-12-17)15-9-26-22(24)27-10-15/h5-6,9-13H,3-4,7-8,14H2,1-2H3,(H2,24,26,27)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104676
PNG
(US8575201, 167)
Show SMILES Nc1ncc(cc1C#N)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1cnn(c1)C1COC1
Show InChI InChI=1S/C23H20N8O2/c24-7-14-6-15(8-27-20(14)25)19-3-2-17(10-26-19)23(4-1-5-23)22-29-21(33-30-22)16-9-28-31(11-16)18-12-32-13-18/h2-3,6,8-11,18H,1,4-5,12-13H2,(H2,25,27)
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n/an/a 140n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104523
PNG
(US8575201, 14)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1c[nH]nn1
Show InChI InChI=1S/C17H15N9O/c18-16-20-6-10(7-21-16)12-3-2-11(8-19-12)17(4-1-5-17)15-23-14(27-25-15)13-9-22-26-24-13/h2-3,6-9H,1,4-5H2,(H2,18,20,21)(H,22,24,26)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104579
PNG
(US8575201, 70)
Show SMILES NC(=O)Cn1cc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C20H19N9O2/c21-16(30)11-29-10-13(8-26-29)17-27-18(28-31-17)20(4-1-5-20)14-2-3-15(23-9-14)12-6-24-19(22)25-7-12/h2-3,6-10H,1,4-5,11H2,(H2,21,30)(H2,22,24,25)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104658
PNG
(US8575201, 149)
Show SMILES CC(C)(C(N)=O)n1cc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C22H23N9O2/c1-21(2,18(23)32)31-12-14(10-28-31)17-29-19(30-33-17)22(6-3-7-22)15-4-5-16(25-11-15)13-8-26-20(24)27-9-13/h4-5,8-12H,3,6-7H2,1-2H3,(H2,23,32)(H2,24,26,27)
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n/an/a 160n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104663
PNG
(US8575201, 154)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)N1CCC(O)CC1
Show InChI InChI=1S/C20H23N7O2/c21-18-23-10-13(11-24-18)16-3-2-14(12-22-16)20(6-1-7-20)17-25-19(29-26-17)27-8-4-15(28)5-9-27/h2-3,10-12,15,28H,1,4-9H2,(H2,21,23,24)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104616
PNG
(US8575201, 107)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1cnccc1O
Show InChI InChI=1S/C20H17N7O2/c21-19-24-8-12(9-25-19)15-3-2-13(10-23-15)20(5-1-6-20)18-26-17(29-27-18)14-11-22-7-4-16(14)28/h2-4,7-11H,1,5-6H2,(H,22,28)(H2,21,24,25)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104675
PNG
(US8575201, 166)
Show SMILES CC(C)(O)Cn1cc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)c(c1)C#N
Show InChI InChI=1S/C24H24N8O2/c1-23(2,33)14-32-13-17(11-29-32)21-30-22(31-34-21)24(6-3-7-24)18-4-5-19(27-12-18)16-8-15(9-25)20(26)28-10-16/h4-5,8,10-13,33H,3,6-7,14H2,1-2H3,(H2,26,28)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104629
PNG
(US8575201, 120)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1nc[nH]n1
Show InChI InChI=1S/C17H15N9O/c18-16-20-6-10(7-21-16)12-3-2-11(8-19-12)17(4-1-5-17)15-24-14(27-26-15)13-22-9-23-25-13/h2-3,6-9H,1,4-5H2,(H2,18,20,21)(H,22,23,25)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104670
PNG
(US8575201, 161)
Show SMILES COC1CCN(C1)C(=O)Cn1cc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C25H27N9O3/c1-36-19-5-8-33(14-19)21(35)15-34-13-17(11-30-34)22-31-23(32-37-22)25(6-2-7-25)18-3-4-20(27-12-18)16-9-28-24(26)29-10-16/h3-4,9-13,19H,2,5-8,14-15H2,1H3,(H2,26,28,29)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104524
PNG
(US8575201, 15)
Show SMILES CN(C)c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C17H19N7O/c1-24(2)16-22-14(23-25-16)17(6-3-7-17)12-4-5-13(19-10-12)11-8-20-15(18)21-9-11/h4-5,8-10H,3,6-7H2,1-2H3,(H2,18,20,21)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104645
PNG
(US8575201, 136)
Show SMILES Cc1cc(-c2nc(no2)C2(CCOCC2)c2ccc(cn2)-c2cnc(N)nc2)n(C)n1
Show InChI InChI=1S/C21H22N8O2/c1-13-9-16(29(2)27-13)18-26-19(28-31-18)21(5-7-30-8-6-21)17-4-3-14(10-23-17)15-11-24-20(22)25-12-15/h3-4,9-12H,5-8H2,1-2H3,(H2,22,24,25)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104646
PNG
(US8575201, 137)
Show SMILES Nc1ncc(cn1)-c1ccc(nc1)C1(CCOCC1)c1noc(n1)-c1cccnc1
Show InChI InChI=1S/C21H19N7O2/c22-20-25-12-16(13-26-20)14-3-4-17(24-11-14)21(5-8-29-9-6-21)19-27-18(30-28-19)15-2-1-7-23-10-15/h1-4,7,10-13H,5-6,8-9H2,(H2,22,25,26)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104574
PNG
(US8575201, 65)
Show SMILES CC(C)(C(O)=O)n1cc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Show InChI InChI=1S/C22H22N8O3/c1-21(2,19(31)32)30-12-14(10-27-30)17-28-18(29-33-17)22(6-3-7-22)15-4-5-16(24-11-15)13-8-25-20(23)26-9-13/h4-5,8-12H,3,6-7H2,1-2H3,(H,31,32)(H2,23,25,26)
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n/an/a 590n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104581
PNG
(US8575201, 72)
Show SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCOCC1)c1noc(n1)-c1cccnc1
Show InChI InChI=1S/C21H19N7O2/c22-20-25-11-15(12-26-20)17-4-3-16(13-24-17)21(5-8-29-9-6-21)19-27-18(30-28-19)14-2-1-7-23-10-14/h1-4,7,10-13H,5-6,8-9H2,(H2,22,25,26)
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n/an/a 610n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104684
PNG
(US8575201, 175)
Show SMILES Cc1nc(N)ncc1-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1cnn(CC(C)(C)O)c1
Show InChI InChI=1S/C23H26N8O2/c1-14-17(11-26-21(24)28-14)18-6-5-16(10-25-18)23(7-4-8-23)20-29-19(33-30-20)15-9-27-31(12-15)13-22(2,3)32/h5-6,9-12,32H,4,7-8,13H2,1-3H3,(H2,24,26,28)
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n/an/a 830n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM104647
PNG
(US8575201, 138)
Show SMILES Nc1ncc(cn1)-c1ccc(nc1)C1(CCOCC1)c1noc(n1)-c1ccncc1
Show InChI InChI=1S/C21H19N7O2/c22-20-25-12-16(13-26-20)15-1-2-17(24-11-15)21(5-9-29-10-6-21)19-27-18(30-28-19)14-3-7-23-8-4-14/h1-4,7-8,11-13H,5-6,9-10H2,(H2,22,25,26)
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n/an/a 970n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...

US Patent US8575201 (2013)


BindingDB Entry DOI: 10.7270/Q2ZK5FBX
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%