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USPatent US8969568

Compile data set for download or QSAR
Found 125 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144512
PNG
(US8969568, 65)
Show SMILES CC[C@@H](Oc1nc(cc2ncccc12)-c1ccc(OC2CCOCC2)c(OC)c1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C27H31N3O5/c1-3-23(18-14-26(31)29-16-18)35-27-20-5-4-10-28-22(20)15-21(30-27)17-6-7-24(25(13-17)32-2)34-19-8-11-33-12-9-19/h4-7,10,13,15,18-19,23H,3,8-9,11-12,14,16H2,1-2H3,(H,29,31)/t18-,23-/m1/s1
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n/an/a 0.100n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144532
PNG
(US8969568, 85)
Show SMILES COc1ccc(cc1OC)-c1cc2ncccc2c(O[C@H](C)[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C22H23N3O4/c1-13(15-10-21(26)24-12-15)29-22-16-5-4-8-23-18(16)11-17(25-22)14-6-7-19(27-2)20(9-14)28-3/h4-9,11,13,15H,10,12H2,1-3H3,(H,24,26)/t13-,15-/m1/s1
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n/an/a 0.100n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144493
PNG
(US8969568, 45)
Show SMILES C[C@@H](Oc1nc(cc2ncccc12)-c1ccc(nc1)N1CCOCC1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C23H25N5O3/c1-15(17-11-22(29)26-14-17)31-23-18-3-2-6-24-20(18)12-19(27-23)16-4-5-21(25-13-16)28-7-9-30-10-8-28/h2-6,12-13,15,17H,7-11,14H2,1H3,(H,26,29)/t15-,17-/m1/s1
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n/an/a 0.100n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144516
PNG
(US8969568, 69)
Show SMILES COc1ccc(cc1OC)-c1cc2ncccc2c(OC([C@H]2CNC(=O)C2)C(F)(F)F)n1 |r|
Show InChI InChI=1S/C22H20F3N3O4/c1-30-17-6-5-12(8-18(17)31-2)15-10-16-14(4-3-7-26-16)21(28-15)32-20(22(23,24)25)13-9-19(29)27-11-13/h3-8,10,13,20H,9,11H2,1-2H3,(H,27,29)/t13-,20?/m1/s1
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Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144510
PNG
(US8969568, 63)
Show SMILES COc1cc(ccc1OC1CCOCC1)-c1cc2ncccc2c(O[C@H](C)[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C26H29N3O5/c1-16(18-13-25(30)28-15-18)33-26-20-4-3-9-27-22(20)14-21(29-26)17-5-6-23(24(12-17)31-2)34-19-7-10-32-11-8-19/h3-6,9,12,14,16,18-19H,7-8,10-11,13,15H2,1-2H3,(H,28,30)/t16-,18-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144559
PNG
(US8969568, 112)
Show SMILES COc1cc(ccc1OC(C)C)-c1cc2ncccc2c(O[C@H](C)[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C24H27N3O4/c1-14(2)30-21-8-7-16(10-22(21)29-4)19-12-20-18(6-5-9-25-20)24(27-19)31-15(3)17-11-23(28)26-13-17/h5-10,12,14-15,17H,11,13H2,1-4H3,(H,26,28)/t15-,17-/m1/s1
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n/an/a 0.100n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144560
PNG
(US8969568, 113)
Show SMILES CC[C@@H](Oc1nc(cc2ncccc12)-c1ccc(OC(C)C)c(OC)c1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C25H29N3O4/c1-5-21(17-12-24(29)27-14-17)32-25-18-7-6-10-26-20(18)13-19(28-25)16-8-9-22(31-15(2)3)23(11-16)30-4/h6-11,13,15,17,21H,5,12,14H2,1-4H3,(H,27,29)/t17-,21-/m1/s1
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n/an/a 0.100n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144541
PNG
(US8969568, 94)
Show SMILES CC[C@@H](Oc1nc(cc2ncccc12)-c1ccc(OC)c(OC)c1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C23H25N3O4/c1-4-19(15-11-22(27)25-13-15)30-23-16-6-5-9-24-18(16)12-17(26-23)14-7-8-20(28-2)21(10-14)29-3/h5-10,12,15,19H,4,11,13H2,1-3H3,(H,25,27)/t15-,19-/m1/s1
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n/an/a 0.100n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144555
PNG
(US8969568, 108)
Show SMILES COc1cc(cc(C)c1OC)-c1cc2ncccc2c(O[C@H](C)[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C23H25N3O4/c1-13-8-15(9-20(28-3)22(13)29-4)18-11-19-17(6-5-7-24-19)23(26-18)30-14(2)16-10-21(27)25-12-16/h5-9,11,14,16H,10,12H2,1-4H3,(H,25,27)/t14-,16-/m1/s1
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Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144518
PNG
(US8969568, 71)
Show SMILES COc1ccc(cc1OC)-c1cc2ncccc2c(O[C@@H]([C@H]2CNC(=O)C2)C(F)(F)F)n1 |r|
Show InChI InChI=1S/C22H20F3N3O4/c1-30-17-6-5-12(8-18(17)31-2)15-10-16-14(4-3-7-26-16)21(28-15)32-20(22(23,24)25)13-9-19(29)27-11-13/h3-8,10,13,20H,9,11H2,1-2H3,(H,27,29)/t13-,20+/m1/s1
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Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144573
PNG
(US8969568, 126)
Show SMILES C[C@@H](Oc1nc(cc2ncccc12)-c1ccccc1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C20H19N3O2/c1-13(15-10-19(24)22-12-15)25-20-16-8-5-9-21-18(16)11-17(23-20)14-6-3-2-4-7-14/h2-9,11,13,15H,10,12H2,1H3,(H,22,24)/t13-,15-/m1/s1
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Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144529
PNG
(US8969568, 82)
Show SMILES COCC[C@@H](Oc1nc(cc2ncccc12)-c1ccc(OC)c(OC)c1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C24H27N3O5/c1-29-10-8-20(16-12-23(28)26-14-16)32-24-17-5-4-9-25-19(17)13-18(27-24)15-6-7-21(30-2)22(11-15)31-3/h4-7,9,11,13,16,20H,8,10,12,14H2,1-3H3,(H,26,28)/t16-,20-/m1/s1
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Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144483
PNG
(US8969568, 35)
Show SMILES COc1cc(cc(OC)c1OC)-c1cc2ncccc2c(O[C@H](C)[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C23H25N3O5/c1-13(15-10-21(27)25-12-15)31-23-16-6-5-7-24-18(16)11-17(26-23)14-8-19(28-2)22(30-4)20(9-14)29-3/h5-9,11,13,15H,10,12H2,1-4H3,(H,25,27)/t13-,15-/m1/s1
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n/an/a 0.200n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144530
PNG
(US8969568, 83)
Show SMILES COc1ccc(cc1OC)-c1cc2ncccc2c(O[C@@H](C)C2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C22H23N3O4/c1-13(15-10-21(26)24-12-15)29-22-16-5-4-8-23-18(16)11-17(25-22)14-6-7-19(27-2)20(9-14)28-3/h4-9,11,13,15H,10,12H2,1-3H3,(H,24,26)/t13-,15?/m0/s1
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Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144519
PNG
(US8969568, 72)
Show SMILES COc1ccc(cc1OC)-c1cc2ncccc2c(OC[C@H]2CNC(=O)O2)n1 |r|
Show InChI InChI=1S/C20H19N3O5/c1-25-17-6-5-12(8-18(17)26-2)15-9-16-14(4-3-7-21-16)19(23-15)27-11-13-10-22-20(24)28-13/h3-9,13H,10-11H2,1-2H3,(H,22,24)/t13-/m1/s1
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Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144539
PNG
(US8969568, 92)
Show SMILES CCC(Oc1nc(cc2ncccc12)-c1ccc(OC)c(OC)c1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C23H25N3O4/c1-4-19(15-11-22(27)25-13-15)30-23-16-6-5-9-24-18(16)12-17(26-23)14-7-8-20(28-2)21(10-14)29-3/h5-10,12,15,19H,4,11,13H2,1-3H3,(H,25,27)/t15-,19?/m1/s1
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Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144489
PNG
(US8969568, 41)
Show SMILES CC[C@@H](Oc1nc(cc2ncccc12)-c1cc(OC)c(OC)c(OC)c1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C24H27N3O5/c1-5-19(15-11-22(28)26-13-15)32-24-16-7-6-8-25-18(16)12-17(27-24)14-9-20(29-2)23(31-4)21(10-14)30-3/h6-10,12,15,19H,5,11,13H2,1-4H3,(H,26,28)/t15-,19-/m1/s1
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Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144494
PNG
(US8969568, 46)
Show SMILES COc1ccc(cn1)-c1cc2ncccc2c(O[C@H](C)[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C20H20N4O3/c1-12(14-8-18(25)22-11-14)27-20-15-4-3-7-21-17(15)9-16(24-20)13-5-6-19(26-2)23-10-13/h3-7,9-10,12,14H,8,11H2,1-2H3,(H,22,25)/t12-,14-/m1/s1
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n/an/a 0.400n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144568
PNG
(US8969568, 121)
Show SMILES C[C@@H](Oc1nc(cc2ncccc12)-c1ccc(cc1)C#N)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C21H18N4O2/c1-13(16-9-20(26)24-12-16)27-21-17-3-2-8-23-19(17)10-18(25-21)15-6-4-14(11-22)5-7-15/h2-8,10,13,16H,9,12H2,1H3,(H,24,26)/t13-,16-/m1/s1
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n/an/a 0.400n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144514
PNG
(US8969568, 67)
Show SMILES COc1ccc(cc1OC)-c1cc2ncccc2c(NCc2n[nH]c(=O)o2)n1
Show InChI InChI=1S/C19H17N5O4/c1-26-15-6-5-11(8-16(15)27-2)13-9-14-12(4-3-7-20-14)18(22-13)21-10-17-23-24-19(25)28-17/h3-9H,10H2,1-2H3,(H,21,22)(H,24,25)
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n/an/a 0.400n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144456
PNG
(US8969568, 7)
Show SMILES COc1cc(cc(Cl)c1OC)-c1cc2ncccc2c(O[C@H](C)[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C22H22ClN3O4/c1-12(14-9-20(27)25-11-14)30-22-15-5-4-6-24-18(15)10-17(26-22)13-7-16(23)21(29-3)19(8-13)28-2/h4-8,10,12,14H,9,11H2,1-3H3,(H,25,27)/t12-,14-/m1/s1
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n/an/a 0.5n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144534
PNG
(US8969568, 87)
Show SMILES COc1cc(OC)cc(c1)-c1cc2ncccc2c(O[C@H](C)[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C22H23N3O4/c1-13(15-9-21(26)24-12-15)29-22-18-5-4-6-23-20(18)11-19(25-22)14-7-16(27-2)10-17(8-14)28-3/h4-8,10-11,13,15H,9,12H2,1-3H3,(H,24,26)/t13-,15-/m1/s1
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n/an/a 0.5n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144507
PNG
(US8969568, 60)
Show SMILES COc1cc(ccc1OC1CCOCC1)-c1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C25H27N3O5/c1-30-23-12-17(4-5-22(23)33-18-6-9-31-10-7-18)20-13-21-19(3-2-8-26-21)25(28-20)32-15-16-11-24(29)27-14-16/h2-5,8,12-13,16,18H,6-7,9-11,14-15H2,1H3,(H,27,29)/t16-/m1/s1
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n/an/a 0.5n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144463
PNG
(US8969568, 14)
Show SMILES COc1c(F)cc(cc1F)-c1cc2ncccc2c(O[C@H](C)[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C21H19F2N3O3/c1-11(13-8-19(27)25-10-13)29-21-14-4-3-5-24-18(14)9-17(26-21)12-6-15(22)20(28-2)16(23)7-12/h3-7,9,11,13H,8,10H2,1-2H3,(H,25,27)/t11-,13-/m1/s1
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n/an/a 0.700n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144469
PNG
(US8969568, 20)
Show SMILES CC[C@@H](Oc1nc(cc2ncccc12)-c1cc(OC)c(OCCN2CCOCC2)c(OC)c1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C29H36N4O6/c1-4-24(20-16-27(34)31-18-20)39-29-21-6-5-7-30-23(21)17-22(32-29)19-14-25(35-2)28(26(15-19)36-3)38-13-10-33-8-11-37-12-9-33/h5-7,14-15,17,20,24H,4,8-13,16,18H2,1-3H3,(H,31,34)/t20-,24-/m1/s1
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n/an/a 0.700n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144558
PNG
(US8969568, 111)
Show SMILES COc1cc(ccc1OC(C)C)-c1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C23H25N3O4/c1-14(2)30-20-7-6-16(10-21(20)28-3)18-11-19-17(5-4-8-24-19)23(26-18)29-13-15-9-22(27)25-12-15/h4-8,10-11,14-15H,9,12-13H2,1-3H3,(H,25,27)/t15-/m1/s1
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n/an/a 0.700n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144470
PNG
(US8969568, 21)
Show SMILES COc1cc(cc2OCOc12)-c1cc2ncccc2c(O[C@H](C)[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C22H21N3O5/c1-12(14-8-20(26)24-10-14)30-22-15-4-3-5-23-17(15)9-16(25-22)13-6-18(27-2)21-19(7-13)28-11-29-21/h3-7,9,12,14H,8,10-11H2,1-2H3,(H,24,26)/t12-,14-/m1/s1
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n/an/a 0.700n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144515
PNG
(US8969568, 68)
Show SMILES COc1ccc(cc1OC)-c1cc2ncccc2c(NCc2n[nH]c(=O)[nH]2)n1
Show InChI InChI=1S/C19H18N6O3/c1-27-15-6-5-11(8-16(15)28-2)13-9-14-12(4-3-7-20-14)18(22-13)21-10-17-23-19(26)25-24-17/h3-9H,10H2,1-2H3,(H,21,22)(H2,23,24,25,26)
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n/an/a 0.700n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144508
PNG
(US8969568, 61)
Show SMILES COc1cc(ccc1O[C@@H]1CCCOC1)-c1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C25H27N3O5/c1-30-23-11-17(6-7-22(23)33-18-4-3-9-31-15-18)20-12-21-19(5-2-8-26-21)25(28-20)32-14-16-10-24(29)27-13-16/h2,5-8,11-12,16,18H,3-4,9-10,13-15H2,1H3,(H,27,29)/t16-,18-/m1/s1
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n/an/a 0.700n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144503
PNG
(US8969568, 56)
Show SMILES CCOc1cc(cc(OCC)c1OCC)-c1cc2ncccc2c(O[C@H](C)[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C26H31N3O5/c1-5-31-22-11-17(12-23(32-6-2)25(22)33-7-3)20-14-21-19(9-8-10-27-21)26(29-20)34-16(4)18-13-24(30)28-15-18/h8-12,14,16,18H,5-7,13,15H2,1-4H3,(H,28,30)/t16-,18-/m1/s1
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n/an/a 0.700n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144468
PNG
(US8969568, 19)
Show SMILES COc1cc(cc(OC)c1OCCN1CCOCC1)-c1cc2ncccc2c(O[C@H](C)[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C28H34N4O6/c1-18(20-15-26(33)30-17-20)38-28-21-5-4-6-29-23(21)16-22(31-28)19-13-24(34-2)27(25(14-19)35-3)37-12-9-32-7-10-36-11-8-32/h4-6,13-14,16,18,20H,7-12,15,17H2,1-3H3,(H,30,33)/t18-,20-/m1/s1
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n/an/a 0.800n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144549
PNG
(US8969568, 102)
Show SMILES COc1cc(ccc1OCC1CCOCC1)-c1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C26H29N3O5/c1-31-24-12-19(4-5-23(24)33-15-17-6-9-32-10-7-17)21-13-22-20(3-2-8-27-22)26(29-21)34-16-18-11-25(30)28-14-18/h2-5,8,12-13,17-18H,6-7,9-11,14-16H2,1H3,(H,28,30)/t18-/m1/s1
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n/an/a 0.900n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144495
PNG
(US8969568, 47 | US8969568, 52 | US8969568, 78)
Show SMILES COc1ccc(cc1OC)-c1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C21H21N3O4/c1-26-18-6-5-14(9-19(18)27-2)16-10-17-15(4-3-7-22-17)21(24-16)28-12-13-8-20(25)23-11-13/h3-7,9-10,13H,8,11-12H2,1-2H3,(H,23,25)/t13-/m1/s1
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n/an/a 0.900n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144459
PNG
(US8969568, 10)
Show SMILES COc1cc(ccc1OC1CCS(=O)(=O)CC1)-c1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C25H27N3O6S/c1-32-23-12-17(4-5-22(23)34-18-6-9-35(30,31)10-7-18)20-13-21-19(3-2-8-26-21)25(28-20)33-15-16-11-24(29)27-14-16/h2-5,8,12-13,16,18H,6-7,9-11,14-15H2,1H3,(H,27,29)/t16-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144502
PNG
(US8969568, 55)
Show SMILES COc1cc(ccc1O[C@@H]1CCOC1)-c1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C24H25N3O5/c1-29-22-10-16(4-5-21(22)32-17-6-8-30-14-17)19-11-20-18(3-2-7-25-20)24(27-19)31-13-15-9-23(28)26-12-15/h2-5,7,10-11,15,17H,6,8-9,12-14H2,1H3,(H,26,28)/t15-,17-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144471
PNG
(US8969568, 22)
Show SMILES C[C@@H](Oc1nc(cc2ncccc12)-c1ccc(=O)[nH]c1)[C@H]1CNC(=O)C1 |r|
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n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144476
PNG
(US8969568, 27)
Show SMILES COc1cc(cc(OC)c1OC)-c1cc2ncccc2c(OC[C@H]2CNC(=O)O2)n1 |r|
Show InChI InChI=1S/C21H21N3O6/c1-26-17-7-12(8-18(27-2)19(17)28-3)15-9-16-14(5-4-6-22-16)20(24-15)29-11-13-10-23-21(25)30-13/h4-9,13H,10-11H2,1-3H3,(H,23,25)/t13-/m1/s1
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n/an/a 1.20n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144501
PNG
(US8969568, 54)
Show SMILES COc1cc(ccc1O[C@H]1CCOC1)-c1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C24H25N3O5/c1-29-22-10-16(4-5-21(22)32-17-6-8-30-14-17)19-11-20-18(3-2-7-25-20)24(27-19)31-13-15-9-23(28)26-12-15/h2-5,7,10-11,15,17H,6,8-9,12-14H2,1H3,(H,26,28)/t15-,17+/m1/s1
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n/an/a 1.40n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144545
PNG
(US8969568, 98)
Show SMILES CCCC(Oc1nc(cc2ncccc12)-c1ccc(OC)c(OC)c1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C24H27N3O4/c1-4-6-20(16-12-23(28)26-14-16)31-24-17-7-5-10-25-19(17)13-18(27-24)15-8-9-21(29-2)22(11-15)30-3/h5,7-11,13,16,20H,4,6,12,14H2,1-3H3,(H,26,28)/t16-,20?/m1/s1
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n/an/a 1.70n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144509
PNG
(US8969568, 62)
Show SMILES COc1cc(ccc1O[C@H]1CCCOC1)-c1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C25H27N3O5/c1-30-23-11-17(6-7-22(23)33-18-4-3-9-31-15-18)20-12-21-19(5-2-8-26-21)25(28-20)32-14-16-10-24(29)27-13-16/h2,5-8,11-12,16,18H,3-4,9-10,13-15H2,1H3,(H,27,29)/t16-,18+/m1/s1
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n/an/a 1.80n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144453
PNG
(US10947243, Example 4 | US8969568, 4 | US9914735, ...)
Show SMILES COc1cc(ccc1OC(F)(F)F)-c1cc2ncccc2c(O[C@H](C)[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C22H20F3N3O4/c1-12(14-9-20(29)27-11-14)31-21-15-4-3-7-26-17(15)10-16(28-21)13-5-6-18(19(8-13)30-2)32-22(23,24)25/h3-8,10,12,14H,9,11H2,1-2H3,(H,27,29)/t12-,14-/m1/s1
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n/an/a 1.90n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144565
PNG
(US8969568, 118)
Show SMILES COc1ccc(cc1)-c1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C20H19N3O3/c1-25-15-6-4-14(5-7-15)17-10-18-16(3-2-8-21-18)20(23-17)26-12-13-9-19(24)22-11-13/h2-8,10,13H,9,11-12H2,1H3,(H,22,24)/t13-/m1/s1
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n/an/a 2.10n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144504
PNG
(US8969568, 103 | US8969568, 104 | US8969568, 105 |...)
Show SMILES Cc1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C14H15N3O2/c1-9-5-12-11(3-2-4-15-12)14(17-9)19-8-10-6-13(18)16-7-10/h2-5,10H,6-8H2,1H3,(H,16,18)/t10-/m1/s1
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n/an/a 2.10n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144499
PNG
(US8969568, 51)
Show SMILES COC[C@@H](C)Oc1ccc(cc1OC)-c1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C24H27N3O5/c1-15(13-29-2)32-21-7-6-17(10-22(21)30-3)19-11-20-18(5-4-8-25-20)24(27-19)31-14-16-9-23(28)26-12-16/h4-8,10-11,15-16H,9,12-14H2,1-3H3,(H,26,28)/t15-,16-/m1/s1
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n/an/a 2.30n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144498
PNG
(US8969568, 50)
Show SMILES COC[C@H](C)Oc1ccc(cc1OC)-c1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C24H27N3O5/c1-15(13-29-2)32-21-7-6-17(10-22(21)30-3)19-11-20-18(5-4-8-25-20)24(27-19)31-14-16-9-23(28)26-12-16/h4-8,10-11,15-16H,9,12-14H2,1-3H3,(H,26,28)/t15-,16+/m0/s1
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n/an/a 2.70n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144457
PNG
(US8969568, 8)
Show SMILES COc1cc(cc(OC)c1Cl)-c1cc2ncccc2c(O[C@H](C)[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C22H22ClN3O4/c1-12(14-9-20(27)25-11-14)30-22-15-5-4-6-24-17(15)10-16(26-22)13-7-18(28-2)21(23)19(8-13)29-3/h4-8,10,12,14H,9,11H2,1-3H3,(H,25,27)/t12-,14-/m1/s1
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n/an/a 3n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144452
PNG
(US8969568, 3)
Show SMILES C[C@@H](Oc1nc(cc2ncccc12)-c1ccc(nc1)C(F)(F)F)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C20H17F3N4O2/c1-11(13-7-18(28)26-10-13)29-19-14-3-2-6-24-16(14)8-15(27-19)12-4-5-17(25-9-12)20(21,22)23/h2-6,8-9,11,13H,7,10H2,1H3,(H,26,28)/t11-,13-/m1/s1
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n/an/a 3.70n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144566
PNG
(US8969568, 119)
Show SMILES CC(C)Oc1ccc(cc1)-c1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C22H23N3O3/c1-14(2)28-17-7-5-16(6-8-17)19-11-20-18(4-3-9-23-20)22(25-19)27-13-15-10-21(26)24-12-15/h3-9,11,14-15H,10,12-13H2,1-2H3,(H,24,26)/t15-/m1/s1
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n/an/a 3.70n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144548
PNG
(US8969568, 101)
Show SMILES CCCCC(Oc1nc(cc2ncccc12)-c1ccc(OC)c(OC)c1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C25H29N3O4/c1-4-5-8-21(17-13-24(29)27-15-17)32-25-18-7-6-11-26-20(18)14-19(28-25)16-9-10-22(30-2)23(12-16)31-3/h6-7,9-12,14,17,21H,4-5,8,13,15H2,1-3H3,(H,27,29)/t17-,21?/m1/s1
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n/an/a 3.80n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144513
PNG
(US8969568, 66)
Show SMILES COc1ccc(cc1OC)-c1cc2ncccc2c(OCc2n[nH]c(=O)o2)n1
Show InChI InChI=1S/C19H16N4O5/c1-25-15-6-5-11(8-16(15)26-2)13-9-14-12(4-3-7-20-14)18(21-13)27-10-17-22-23-19(24)28-17/h3-9H,10H2,1-2H3,(H,23,24)
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n/an/a 4.10n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144495
PNG
(US8969568, 47 | US8969568, 52 | US8969568, 78)
Show SMILES COc1ccc(cc1OC)-c1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C21H21N3O4/c1-26-18-6-5-14(9-19(18)27-2)16-10-17-15(4-3-7-22-17)21(24-16)28-12-13-8-20(25)23-11-13/h3-7,9-10,13H,8,11-12H2,1-2H3,(H,23,25)/t13-/m1/s1
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n/an/a 4.10n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144475
PNG
(US8969568, 26)
Show SMILES COc1cc(cc(OC)c1OC)-c1cc2ncccc2c(OC([C@H]2CNC(=O)C2)C(F)(F)F)n1 |r|
Show InChI InChI=1S/C23H22F3N3O5/c1-31-17-7-12(8-18(32-2)20(17)33-3)15-10-16-14(5-4-6-27-16)22(29-15)34-21(23(24,25)26)13-9-19(30)28-11-13/h4-8,10,13,21H,9,11H2,1-3H3,(H,28,30)/t13-,21?/m1/s1
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n/an/a 4.10n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144544
PNG
(US8969568, 97)
Show SMILES COc1ccc(cc1OC)-c1cc2ncccc2c(OC(C=C)[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C23H23N3O4/c1-4-19(15-11-22(27)25-13-15)30-23-16-6-5-9-24-18(16)12-17(26-23)14-7-8-20(28-2)21(10-14)29-3/h4-10,12,15,19H,1,11,13H2,2-3H3,(H,25,27)/t15-,19?/m1/s1
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n/an/a 4.30n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144485
PNG
(US8969568, 37)
Show SMILES COc1cc(cc(OC)c1OC)-c1cc2[n+]([O-])cccc2c(O[C@H](C)[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C23H25N3O6/c1-13(15-10-21(27)24-12-15)32-23-16-6-5-7-26(28)18(16)11-17(25-23)14-8-19(29-2)22(31-4)20(9-14)30-3/h5-9,11,13,15H,10,12H2,1-4H3,(H,24,27)/t13-,15-/m1/s1
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n/an/a 4.30n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144554
PNG
(US8969568, 107)
Show SMILES COc1cc(cc(C)c1OC)-c1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C22H23N3O4/c1-13-7-15(9-19(27-2)21(13)28-3)17-10-18-16(5-4-6-23-18)22(25-17)29-12-14-8-20(26)24-11-14/h4-7,9-10,14H,8,11-12H2,1-3H3,(H,24,26)/t14-/m1/s1
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n/an/a 4.5n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144504
PNG
(US8969568, 103 | US8969568, 104 | US8969568, 105 |...)
Show SMILES Cc1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C14H15N3O2/c1-9-5-12-11(3-2-4-15-12)14(17-9)19-8-10-6-13(18)16-7-10/h2-5,10H,6-8H2,1H3,(H,16,18)/t10-/m1/s1
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n/an/a 4.70n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144546
PNG
(US8969568, 99)
Show SMILES COc1ccc(cc1OC)-c1cc2ncccc2c(OC(C(C)C)[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C24H27N3O4/c1-14(2)23(16-11-22(28)26-13-16)31-24-17-6-5-9-25-19(17)12-18(27-24)15-7-8-20(29-3)21(10-15)30-4/h5-10,12,14,16,23H,11,13H2,1-4H3,(H,26,28)/t16-,23?/m1/s1
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n/an/a 4.70n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144504
PNG
(US8969568, 103 | US8969568, 104 | US8969568, 105 |...)
Show SMILES Cc1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C14H15N3O2/c1-9-5-12-11(3-2-4-15-12)14(17-9)19-8-10-6-13(18)16-7-10/h2-5,10H,6-8H2,1H3,(H,16,18)/t10-/m1/s1
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n/an/a 4.70n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144517
PNG
(US8969568, 70)
Show SMILES COc1ccc(cc1OC)-c1cc2ncccc2c(O[C@H]([C@H]2CNC(=O)C2)C(F)(F)F)n1 |r|
Show InChI InChI=1S/C22H20F3N3O4/c1-30-17-6-5-12(8-18(17)31-2)15-10-16-14(4-3-7-26-16)21(28-15)32-20(22(23,24)25)13-9-19(29)27-11-13/h3-8,10,13,20H,9,11H2,1-2H3,(H,27,29)/t13-,20-/m1/s1
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n/an/a 4.80n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144473
PNG
(US8969568, 24)
Show SMILES COc1cc(cc(OC)c1OC)-c1cc2ncccc2c(NCc2n[nH]c(=O)o2)n1
Show InChI InChI=1S/C20H19N5O5/c1-27-15-7-11(8-16(28-2)18(15)29-3)13-9-14-12(5-4-6-21-14)19(23-13)22-10-17-24-25-20(26)30-17/h4-9H,10H2,1-3H3,(H,22,23)(H,25,26)
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n/an/a 5n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144458
PNG
(US8969568, 9)
Show SMILES COc1cc(cc(Cl)c1OC)-c1cc2[n+]([O-])cccc2c(O[C@H](C)[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C22H22ClN3O5/c1-12(14-9-20(27)24-11-14)31-22-15-5-4-6-26(28)18(15)10-17(25-22)13-7-16(23)21(30-3)19(8-13)29-2/h4-8,10,12,14H,9,11H2,1-3H3,(H,24,27)/t12-,14-/m1/s1
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n/an/a 5n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144504
PNG
(US8969568, 103 | US8969568, 104 | US8969568, 105 |...)
Show SMILES Cc1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C14H15N3O2/c1-9-5-12-11(3-2-4-15-12)14(17-9)19-8-10-6-13(18)16-7-10/h2-5,10H,6-8H2,1H3,(H,16,18)/t10-/m1/s1
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n/an/a 5.10n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144528
PNG
(US8969568, 81)
Show SMILES COCCC(Oc1nc(cc2ncccc12)-c1ccc(OC)c(OC)c1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C24H27N3O5/c1-29-10-8-20(16-12-23(28)26-14-16)32-24-17-5-4-9-25-19(17)13-18(27-24)15-6-7-21(30-2)22(11-15)31-3/h4-7,9,11,13,16,20H,8,10,12,14H2,1-3H3,(H,26,28)/t16-,20?/m1/s1
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n/an/a 5.5n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144542
PNG
(US8969568, 95)
Show SMILES COc1ccc(cc1OC)-c1cc2ncccc2c(OC[C@H]2CNC(=O)C2(C)C)n1 |r|
Show InChI InChI=1S/C23H25N3O4/c1-23(2)15(12-25-22(23)27)13-30-21-16-6-5-9-24-18(16)11-17(26-21)14-7-8-19(28-3)20(10-14)29-4/h5-11,15H,12-13H2,1-4H3,(H,25,27)/t15-/m1/s1
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n/an/a 5.70n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144533
PNG
(US8969568, 86)
Show SMILES COc1ccc(cc1OC)-c1cc2ncccc2c(OC[C@H]2CNC(=O)[C@@H]2C)n1 |r|
Show InChI InChI=1S/C22H23N3O4/c1-13-15(11-24-21(13)26)12-29-22-16-5-4-8-23-18(16)10-17(25-22)14-6-7-19(27-2)20(9-14)28-3/h4-10,13,15H,11-12H2,1-3H3,(H,24,26)/t13-,15-/m1/s1
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n/an/a 6n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144504
PNG
(US8969568, 103 | US8969568, 104 | US8969568, 105 |...)
Show SMILES Cc1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C14H15N3O2/c1-9-5-12-11(3-2-4-15-12)14(17-9)19-8-10-6-13(18)16-7-10/h2-5,10H,6-8H2,1H3,(H,16,18)/t10-/m1/s1
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n/an/a 6.20n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144511
PNG
(US8969568, 64)
Show SMILES COc1cc(ccc1OC1CCOCC1)-c1cc2ncccc2c(NCc2ccc(=O)[nH]c2)n1
Show InChI InChI=1S/C26H26N4O4/c1-32-24-13-18(5-6-23(24)34-19-8-11-33-12-9-19)21-14-22-20(3-2-10-27-22)26(30-21)29-16-17-4-7-25(31)28-15-17/h2-7,10,13-15,19H,8-9,11-12,16H2,1H3,(H,28,31)(H,29,30)
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n/an/a 6.30n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144496
PNG
(US8969568, 48)
Show SMILES COc1ccc(cc1F)-c1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C20H18FN3O3/c1-26-18-5-4-13(8-15(18)21)16-9-17-14(3-2-6-22-17)20(24-16)27-11-12-7-19(25)23-10-12/h2-6,8-9,12H,7,10-11H2,1H3,(H,23,25)/t12-/m1/s1
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n/an/a 6.30n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144481
PNG
(US8969568, 32)
Show SMILES COc1cc(cc(OC)c1OC)-c1cc2ncccc2c(OCC2CNC(=O)C2)n1
Show InChI InChI=1S/C22H23N3O5/c1-27-18-8-14(9-19(28-2)21(18)29-3)16-10-17-15(5-4-6-23-17)22(25-16)30-12-13-7-20(26)24-11-13/h4-6,8-10,13H,7,11-12H2,1-3H3,(H,24,26)
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n/an/a 7.10n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144465
PNG
(US8969568, 16)
Show SMILES COc1ccc(cc1Cl)-c1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C20H18ClN3O3/c1-26-18-5-4-13(8-15(18)21)16-9-17-14(3-2-6-22-17)20(24-16)27-11-12-7-19(25)23-10-12/h2-6,8-9,12H,7,10-11H2,1H3,(H,23,25)/t12-/m1/s1
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n/an/a 7.20n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144564
PNG
(US8969568, 117)
Show SMILES C[C@@H](Oc1nc(cc2ncccc12)-c1ccccn1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C19H18N4O2/c1-12(13-9-18(24)22-11-13)25-19-14-5-4-8-21-16(14)10-17(23-19)15-6-2-3-7-20-15/h2-8,10,12-13H,9,11H2,1H3,(H,22,24)/t12-,13-/m1/s1
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n/an/a 7.20n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144547
PNG
(US8969568, 100)
Show SMILES COc1ccc(cc1OC)-c1cc2ncccc2c(OC(CC(C)C)[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C25H29N3O4/c1-15(2)10-22(17-12-24(29)27-14-17)32-25-18-6-5-9-26-20(18)13-19(28-25)16-7-8-21(30-3)23(11-16)31-4/h5-9,11,13,15,17,22H,10,12,14H2,1-4H3,(H,27,29)/t17-,22?/m1/s1
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n/an/a 7.30n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144504
PNG
(US8969568, 103 | US8969568, 104 | US8969568, 105 |...)
Show SMILES Cc1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C14H15N3O2/c1-9-5-12-11(3-2-4-15-12)14(17-9)19-8-10-6-13(18)16-7-10/h2-5,10H,6-8H2,1H3,(H,16,18)/t10-/m1/s1
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n/an/a 7.40n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144571
PNG
(US8969568, 124)
Show SMILES O=C1C[C@@H](COc2nc(cc3ncccc23)-c2ccccc2)CN1 |r|
Show InChI InChI=1S/C19H17N3O2/c23-18-9-13(11-21-18)12-24-19-15-7-4-8-20-17(15)10-16(22-19)14-5-2-1-3-6-14/h1-8,10,13H,9,11-12H2,(H,21,23)/t13-/m1/s1
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n/an/a 7.5n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144535
PNG
(US8969568, 88)
Show SMILES COc1ccc(cc1OC)-c1cc2ncccc2c(OCCC2CNC(=O)C2)n1
Show InChI InChI=1S/C22H23N3O4/c1-27-19-6-5-15(11-20(19)28-2)17-12-18-16(4-3-8-23-18)22(25-17)29-9-7-14-10-21(26)24-13-14/h3-6,8,11-12,14H,7,9-10,13H2,1-2H3,(H,24,26)
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n/an/a 8.10n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144520
PNG
(US8969568, 73)
Show SMILES COc1ccc(cc1OC)-c1cc2ncccc2c(OCC2CC(=O)NO2)n1
Show InChI InChI=1S/C20H19N3O5/c1-25-17-6-5-12(8-18(17)26-2)15-10-16-14(4-3-7-21-16)20(22-15)27-11-13-9-19(24)23-28-13/h3-8,10,13H,9,11H2,1-2H3,(H,23,24)
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n/an/a 10n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144464
PNG
(US8969568, 15)
Show SMILES Cc1ccc(OC2CCOCC2)c(c1)C(F)(F)F
Show InChI InChI=1S/C13H15F3O2/c1-9-2-3-12(11(8-9)13(14,15)16)18-10-4-6-17-7-5-10/h2-3,8,10H,4-7H2,1H3
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n/an/a 10.1n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144474
PNG
(US8969568, 25)
Show SMILES COc1cc(cc(OC)c1OC)-c1cc2ncccc2c(NCc2n[nH]c(=O)[nH]2)n1
Show InChI InChI=1S/C20H20N6O4/c1-28-15-7-11(8-16(29-2)18(15)30-3)13-9-14-12(5-4-6-21-14)19(23-13)22-10-17-24-20(27)26-25-17/h4-9H,10H2,1-3H3,(H,22,23)(H2,24,25,26,27)
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n/an/a 10.3n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144495
PNG
(US8969568, 47 | US8969568, 52 | US8969568, 78)
Show SMILES COc1ccc(cc1OC)-c1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C21H21N3O4/c1-26-18-6-5-14(9-19(18)27-2)16-10-17-15(4-3-7-22-17)21(24-16)28-12-13-8-20(25)23-11-13/h3-7,9-10,13H,8,11-12H2,1-2H3,(H,23,25)/t13-/m1/s1
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n/an/a 10.7n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144490
PNG
(US8969568, 42)
Show SMILES COc1cc(cc(OC)c1OC)-c1cc2ncccc2c(OC[C@H]2CNC(=O)C2(C)C)n1 |r|
Show InChI InChI=1S/C24H27N3O5/c1-24(2)15(12-26-23(24)28)13-32-22-16-7-6-8-25-18(16)11-17(27-22)14-9-19(29-3)21(31-5)20(10-14)30-4/h6-11,15H,12-13H2,1-5H3,(H,26,28)/t15-/m1/s1
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n/an/a 11.7n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144527
PNG
(US8969568, 80)
Show SMILES COc1ccc(cc1OC)-c1cc2ncccc2c(NC[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C21H22N4O3/c1-27-18-6-5-14(9-19(18)28-2)16-10-17-15(4-3-7-22-17)21(25-16)24-12-13-8-20(26)23-11-13/h3-7,9-10,13H,8,11-12H2,1-2H3,(H,23,26)(H,24,25)/t13-/m1/s1
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n/an/a 11.8n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144454
PNG
(US8969568, 5)
Show SMILES COc1ccc(cc1C(F)(F)F)-c1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C21H18F3N3O3/c1-29-18-5-4-13(8-15(18)21(22,23)24)16-9-17-14(3-2-6-25-17)20(27-16)30-11-12-7-19(28)26-10-12/h2-6,8-9,12H,7,10-11H2,1H3,(H,26,28)/t12-/m1/s1
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n/an/a 12.1n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144451
PNG
(US8969568, 2)
Show SMILES C[C@@H](Oc1nc(cc2ncccc12)-c1cc(F)c(Cl)c(F)c1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C20H16ClF2N3O2/c1-10(12-7-18(27)25-9-12)28-20-13-3-2-4-24-17(13)8-16(26-20)11-5-14(22)19(21)15(23)6-11/h2-6,8,10,12H,7,9H2,1H3,(H,25,27)/t10-,12-/m1/s1
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n/an/a 12.4n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144482
PNG
(US8969568, 34)
Show SMILES COCC[C@@H](Oc1nc(cc2ncccc12)-c1cc(OC)c(OC)c(OC)c1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C25H29N3O6/c1-30-9-7-20(16-12-23(29)27-14-16)34-25-17-6-5-8-26-19(17)13-18(28-25)15-10-21(31-2)24(33-4)22(11-15)32-3/h5-6,8,10-11,13,16,20H,7,9,12,14H2,1-4H3,(H,27,29)/t16-,20-/m1/s1
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n/an/a 12.4n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144450
PNG
(US8969568, 1)
Show SMILES C[C@@H](Oc1nc(cc2ncccc12)-c1ccc(OC(F)(F)F)c(F)c1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C21H17F4N3O3/c1-11(13-8-19(29)27-10-13)30-20-14-3-2-6-26-17(14)9-16(28-20)12-4-5-18(15(22)7-12)31-21(23,24)25/h2-7,9,11,13H,8,10H2,1H3,(H,27,29)/t11-,13-/m1/s1
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n/an/a 13.1n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144487
PNG
(US8969568, 39)
Show SMILES COc1cc(cc(OC)c1OC)-c1cc2ncccc2c(N[C@H](C)[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C23H26N4O4/c1-13(15-10-21(28)25-12-15)26-23-16-6-5-7-24-18(16)11-17(27-23)14-8-19(29-2)22(31-4)20(9-14)30-3/h5-9,11,13,15H,10,12H2,1-4H3,(H,25,28)(H,26,27)/t13-,15-/m1/s1
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n/an/a 13.3n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144562
PNG
(US8969568, 115)
Show SMILES C[C@@H](Oc1nc(cc2ncccc12)-c1ccccc1F)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C20H18FN3O2/c1-12(13-9-19(25)23-11-13)26-20-15-6-4-8-22-17(15)10-18(24-20)14-5-2-3-7-16(14)21/h2-8,10,12-13H,9,11H2,1H3,(H,23,25)/t12-,13-/m1/s1
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n/an/a 13.4n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144467
PNG
(US8969568, 18)
Show SMILES COc1cc(C)cc(OC)c1OCCN1CCOCC1
Show InChI InChI=1S/C15H23NO4/c1-12-10-13(17-2)15(14(11-12)18-3)20-9-6-16-4-7-19-8-5-16/h10-11H,4-9H2,1-3H3
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n/an/a 13.6n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144504
PNG
(US8969568, 103 | US8969568, 104 | US8969568, 105 |...)
Show SMILES Cc1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C14H15N3O2/c1-9-5-12-11(3-2-4-15-12)14(17-9)19-8-10-6-13(18)16-7-10/h2-5,10H,6-8H2,1H3,(H,16,18)/t10-/m1/s1
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n/an/a 13.7n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144497
PNG
(US8969568, 49)
Show SMILES COc1cc(ccc1F)-c1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C20H18FN3O3/c1-26-18-8-13(4-5-15(18)21)16-9-17-14(3-2-6-22-17)20(24-16)27-11-12-7-19(25)23-10-12/h2-6,8-9,12H,7,10-11H2,1H3,(H,23,25)/t12-/m1/s1
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n/an/a 14n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144466
PNG
(US8969568, 17)
Show SMILES COc1cc(ccc1Cl)-c1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C20H18ClN3O3/c1-26-18-8-13(4-5-15(18)21)16-9-17-14(3-2-6-22-17)20(24-16)27-11-12-7-19(25)23-10-12/h2-6,8-9,12H,7,10-11H2,1H3,(H,23,25)/t12-/m1/s1
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n/an/a 14.5n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144505
PNG
(US8969568, 58)
Show SMILES O=C1C[C@@H](COc2nc(cc3ncccc23)-c2ccc3OCOc3c2)CN1 |r|
Show InChI InChI=1S/C20H17N3O4/c24-19-6-12(9-22-19)10-25-20-14-2-1-5-21-16(14)8-15(23-20)13-3-4-17-18(7-13)27-11-26-17/h1-5,7-8,12H,6,9-11H2,(H,22,24)/t12-/m1/s1
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n/an/a 15.3n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144538
PNG
(US8969568, 91)
Show SMILES COc1ccc(cc1OC)-c1cc2ncccc2c(NCc2ccc(=O)[nH]c2)n1
Show InChI InChI=1S/C22H20N4O3/c1-28-19-7-6-15(10-20(19)29-2)17-11-18-16(4-3-9-23-18)22(26-17)25-13-14-5-8-21(27)24-12-14/h3-12H,13H2,1-2H3,(H,24,27)(H,25,26)
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n/an/a 16n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144492
PNG
(US8969568, 44)
Show SMILES COc1cc(cc(OC)c1OC1CCOCC1)-c1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C26H29N3O6/c1-31-22-11-17(12-23(32-2)25(22)35-18-5-8-33-9-6-18)20-13-21-19(4-3-7-27-21)26(29-20)34-15-16-10-24(30)28-14-16/h3-4,7,11-13,16,18H,5-6,8-10,14-15H2,1-2H3,(H,28,30)/t16-/m1/s1
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n/an/a 16.1n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144472
PNG
(US8969568, 23)
Show SMILES CN1CCOc2cc(cnc12)-c1cc2ncccc2c(OCC2CNC(=O)C2)n1
Show InChI InChI=1S/C21H21N5O3/c1-26-5-6-28-18-8-14(11-24-20(18)26)16-9-17-15(3-2-4-22-17)21(25-16)29-12-13-7-19(27)23-10-13/h2-4,8-9,11,13H,5-7,10,12H2,1H3,(H,23,27)
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n/an/a 17.2n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144480
PNG
(US8969568, 31)
Show SMILES COc1cc(cc(OC)c1OC)-c1cc2ncccc2c(OC(C)C2CC(=O)NO2)n1
Show InChI InChI=1S/C22H23N3O6/c1-12(17-11-20(26)25-31-17)30-22-14-6-5-7-23-16(14)10-15(24-22)13-8-18(27-2)21(29-4)19(9-13)28-3/h5-10,12,17H,11H2,1-4H3,(H,25,26)
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n/an/a 17.3n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144484
PNG
(US8969568, 36)
Show SMILES COc1cc(cc(OC)c1OC)-c1cc2ncccc2c(OC[C@H]2CNC(=O)[C@@H]2C)n1 |r|
Show InChI InChI=1S/C23H25N3O5/c1-13-15(11-25-22(13)27)12-31-23-16-6-5-7-24-18(16)10-17(26-23)14-8-19(28-2)21(30-4)20(9-14)29-3/h5-10,13,15H,11-12H2,1-4H3,(H,25,27)/t13-,15-/m1/s1
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n/an/a 17.4n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144504
PNG
(US8969568, 103 | US8969568, 104 | US8969568, 105 |...)
Show SMILES Cc1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C14H15N3O2/c1-9-5-12-11(3-2-4-15-12)14(17-9)19-8-10-6-13(18)16-7-10/h2-5,10H,6-8H2,1H3,(H,16,18)/t10-/m1/s1
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n/an/a 17.8n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144504
PNG
(US8969568, 103 | US8969568, 104 | US8969568, 105 |...)
Show SMILES Cc1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C14H15N3O2/c1-9-5-12-11(3-2-4-15-12)14(17-9)19-8-10-6-13(18)16-7-10/h2-5,10H,6-8H2,1H3,(H,16,18)/t10-/m1/s1
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n/an/a 20.4n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144462
PNG
(US8969568, 13)
Show SMILES COc1c(F)cc(cc1F)-c1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C20H17F2N3O3/c1-27-19-14(21)6-12(7-15(19)22)16-8-17-13(3-2-4-23-17)20(25-16)28-10-11-5-18(26)24-9-11/h2-4,6-8,11H,5,9-10H2,1H3,(H,24,26)/t11-/m1/s1
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n/an/a 22.3n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144537
PNG
(US8969568, 90)
Show SMILES COc1ccc(cc1OC)-c1cc2ncccc2c(NC[C@H]2CC(=O)N[C@@H]2C)n1 |r|
Show InChI InChI=1S/C22H24N4O3/c1-13-15(10-21(27)25-13)12-24-22-16-5-4-8-23-18(16)11-17(26-22)14-6-7-19(28-2)20(9-14)29-3/h4-9,11,13,15H,10,12H2,1-3H3,(H,24,26)(H,25,27)/t13-,15-/m1/s1
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n/an/a 22.7n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144455
PNG
(US8969568, 6)
Show SMILES COc1cc(cc(Cl)c1OC)-c1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C21H20ClN3O4/c1-27-18-8-13(7-15(22)20(18)28-2)16-9-17-14(4-3-5-23-17)21(25-16)29-11-12-6-19(26)24-10-12/h3-5,7-9,12H,6,10-11H2,1-2H3,(H,24,26)/t12-/m1/s1
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n/an/a 25.3n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144521
PNG
(US8969568, 74)
Show SMILES COc1ccc(cc1OC)-c1cc2ncccc2c(OC[C@H]2CNC(=O)N2)n1 |r|
Show InChI InChI=1S/C20H20N4O4/c1-26-17-6-5-12(8-18(17)27-2)15-9-16-14(4-3-7-21-16)19(24-15)28-11-13-10-22-20(25)23-13/h3-9,13H,10-11H2,1-2H3,(H2,22,23,25)/t13-/m1/s1
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n/an/a 27.3n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144460
PNG
(US8969568, 11)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C20H16F3N3O2/c21-20(22,23)14-5-3-13(4-6-14)16-9-17-15(2-1-7-24-17)19(26-16)28-11-12-8-18(27)25-10-12/h1-7,9,12H,8,10-11H2,(H,25,27)/t12-/m1/s1
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n/an/a 34.7n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144523
PNG
(US8969568, 76)
Show SMILES COc1ccc(cc1OC)-c1cc2ncccc2c(NCC2CC(=O)NO2)n1
Show InChI InChI=1S/C20H20N4O4/c1-26-17-6-5-12(8-18(17)27-2)15-10-16-14(4-3-7-21-16)20(23-15)22-11-13-9-19(25)24-28-13/h3-8,10,13H,9,11H2,1-2H3,(H,22,23)(H,24,25)
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n/an/a 38.6n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144536
PNG
(US8969568, 89)
Show SMILES COc1ccc(cc1OC)-c1cc2ncccc2c(OCC2CCC(=O)NC2)n1
Show InChI InChI=1S/C22H23N3O4/c1-27-19-7-6-15(10-20(19)28-2)17-11-18-16(4-3-9-23-18)22(25-17)29-13-14-5-8-21(26)24-12-14/h3-4,6-7,9-11,14H,5,8,12-13H2,1-2H3,(H,24,26)
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n/an/a 40n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144524
PNG
(US8969568, 77)
Show SMILES COc1ccc(cc1OC)-c1cc2ncccc2c(OC[C@H]2CNC(=O)N2C)n1 |r|
Show InChI InChI=1S/C21H22N4O4/c1-25-14(11-23-21(25)26)12-29-20-15-5-4-8-22-17(15)10-16(24-20)13-6-7-18(27-2)19(9-13)28-3/h4-10,14H,11-12H2,1-3H3,(H,23,26)/t14-/m1/s1
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n/an/a 46.3n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144522
PNG
(US8969568, 75)
Show SMILES COc1ccc(cc1OC)-c1cc2ncccc2c(NC[C@H]2CNC(=O)O2)n1 |r|
Show InChI InChI=1S/C20H20N4O4/c1-26-17-6-5-12(8-18(17)27-2)15-9-16-14(4-3-7-21-16)19(24-15)22-10-13-11-23-20(25)28-13/h3-9,13H,10-11H2,1-2H3,(H,22,24)(H,23,25)/t13-/m0/s1
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n/an/a 56.7n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144567
PNG
(US8969568, 120)
Show SMILES O=C1C[C@@H](COc2nc(cc3ncccc23)-c2ccc3CNCCc3c2)CN1 |r|
Show InChI InChI=1S/C22H22N4O2/c27-21-8-14(11-25-21)13-28-22-18-2-1-6-24-20(18)10-19(26-22)16-3-4-17-12-23-7-5-15(17)9-16/h1-4,6,9-10,14,23H,5,7-8,11-13H2,(H,25,27)/t14-/m1/s1
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n/an/a 57.5n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144477
PNG
(US8969568, 28)
Show SMILES COc1cc(cc(OC)c1OC)-c1cc2ncccc2c(OCC2CC(=O)NO2)n1
Show InChI InChI=1S/C21H21N3O6/c1-26-17-7-12(8-18(27-2)20(17)28-3)15-10-16-14(5-4-6-22-16)21(23-15)29-11-13-9-19(25)24-30-13/h4-8,10,13H,9,11H2,1-3H3,(H,24,25)
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n/an/a 67.1n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144506
PNG
(US8969568, 59)
Show SMILES COc1cc(ccc1OC1CCOCC1)-c1cc2ncccc2c(NCc2cc(=O)[nH]o2)n1
Show InChI InChI=1S/C24H24N4O5/c1-30-22-11-15(4-5-21(22)32-16-6-9-31-10-7-16)19-13-20-18(3-2-8-25-20)24(27-19)26-14-17-12-23(29)28-33-17/h2-5,8,11-13,16H,6-7,9-10,14H2,1H3,(H,26,27)(H,28,29)
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n/an/a 78.2n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144479
PNG
(US8969568, 30)
Show SMILES COc1cc(cc(OC)c1OC)-c1cc2ncccc2c(NCc2cc(=O)[nH]o2)n1
Show InChI InChI=1S/C21H20N4O5/c1-27-17-7-12(8-18(28-2)20(17)29-3)15-10-16-14(5-4-6-22-16)21(24-15)23-11-13-9-19(26)25-30-13/h4-10H,11H2,1-3H3,(H,23,24)(H,25,26)
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n/an/a 105n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144569
PNG
(US8969568, 122)
Show SMILES C[C@@H]1[C@@H](COc2nc(cc3ncccc23)-c2ccc(cc2)C#N)CNC1=O |r|
Show InChI InChI=1S/C21H18N4O2/c1-13-16(11-24-20(13)26)12-27-21-17-3-2-8-23-19(17)9-18(25-21)15-6-4-14(10-22)5-7-15/h2-9,13,16H,11-12H2,1H3,(H,24,26)/t13-,16-/m1/s1
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n/an/a 119n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144540
PNG
(US8969568, 93)
Show SMILES CC[C@H](Oc1nc(cc2ncccc12)-c1ccc(OC)c(OC)c1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C23H25N3O4/c1-4-19(15-11-22(27)25-13-15)30-23-16-6-5-9-24-18(16)12-17(26-23)14-7-8-20(28-2)21(10-14)29-3/h5-10,12,15,19H,4,11,13H2,1-3H3,(H,25,27)/t15-,19+/m1/s1
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n/an/a 121n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144531
PNG
(US8969568, 84)
Show SMILES COc1ccc(cc1OC)-c1cc2ncccc2c(O[C@@H](C)[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C22H23N3O4/c1-13(15-10-21(26)24-12-15)29-22-16-5-4-8-23-18(16)11-17(25-22)14-6-7-19(27-2)20(9-14)28-3/h4-9,11,13,15H,10,12H2,1-3H3,(H,24,26)/t13-,15+/m0/s1
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n/an/a 196n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144461
PNG
(US8969568, 12)
Show SMILES Cc1cc(no1)-c1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C17H16N4O3/c1-10-5-15(21-24-10)14-7-13-12(3-2-4-18-13)17(20-14)23-9-11-6-16(22)19-8-11/h2-5,7,11H,6,8-9H2,1H3,(H,19,22)/t11-/m1/s1
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n/an/a 208n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144486
PNG
(US8969568, 38)
Show SMILES COc1cc(cc(OC)c1OC)-c1cc2ncccc2c(NC[C@H]2CC(=O)N[C@@H]2C)n1 |r|
Show InChI InChI=1S/C23H26N4O4/c1-13-15(10-21(28)26-13)12-25-23-16-6-5-7-24-18(16)11-17(27-23)14-8-19(29-2)22(31-4)20(9-14)30-3/h5-9,11,13,15H,10,12H2,1-4H3,(H,25,27)(H,26,28)/t13-,15-/m1/s1
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n/an/a 252n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144488
PNG
(US8969568, 40)
Show SMILES COc1cc(cc(OC)c1OC)-c1cc2ncccc2c(NCc2ccc(=O)[nH]c2)n1
Show InChI InChI=1S/C23H22N4O4/c1-29-19-9-15(10-20(30-2)22(19)31-3)17-11-18-16(5-4-8-24-18)23(27-17)26-13-14-6-7-21(28)25-12-14/h4-12H,13H2,1-3H3,(H,25,28)(H,26,27)
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n/an/a 411n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144543
PNG
(US8969568, 96)
Show SMILES CC[C@H]1NC(=O)C[C@@H]1CNc1nc(cc2ncccc12)-c1ccc(OC)c(OC)c1 |r|
Show InChI InChI=1S/C23H26N4O3/c1-4-17-15(11-22(28)26-17)13-25-23-16-6-5-9-24-19(16)12-18(27-23)14-7-8-20(29-2)21(10-14)30-3/h5-10,12,15,17H,4,11,13H2,1-3H3,(H,25,27)(H,26,28)/t15-,17-/m1/s1
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n/an/a 805n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144491
PNG
(US8969568, 43)
Show SMILES CC[C@H]1NC(=O)C[C@@H]1CNc1nc(cc2ncccc12)-c1cc(OC)c(OC)c(OC)c1 |r|
Show InChI InChI=1S/C24H28N4O4/c1-5-17-15(11-22(29)27-17)13-26-24-16-7-6-8-25-19(16)12-18(28-24)14-9-20(30-2)23(32-4)21(10-14)31-3/h6-10,12,15,17H,5,11,13H2,1-4H3,(H,26,28)(H,27,29)/t15-,17-/m1/s1
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n/an/a 1.53E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144570
PNG
(US8969568, 123)
Show SMILES C[C@@H](Oc1nc(cc2ncccc12)C1CC1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C17H19N3O2/c1-10(12-7-16(21)19-9-12)22-17-13-3-2-6-18-15(13)8-14(20-17)11-4-5-11/h2-3,6,8,10-12H,4-5,7,9H2,1H3,(H,19,21)/t10-,12-/m1/s1
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n/an/a 1.90E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144478
PNG
(US8969568, 29)
Show SMILES COc1cc(cc(OC)c1OC)-c1cc2ncccc2c(NC[C@H]2CNC(=O)O2)n1 |r|
Show InChI InChI=1S/C21H22N4O5/c1-27-17-7-12(8-18(28-2)19(17)29-3)15-9-16-14(5-4-6-22-16)20(25-15)23-10-13-11-24-21(26)30-13/h4-9,13H,10-11H2,1-3H3,(H,23,25)(H,24,26)/t13-/m0/s1
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n/an/a 3.33E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144526
PNG
(US8969568, 79)
Show SMILES COc1cccc(-c2cc3ncccc3c(OC[C@H]3CNC(=O)C3)n2)c1OC |r|
Show InChI InChI=1S/C21H21N3O4/c1-26-18-7-3-5-14(20(18)27-2)17-10-16-15(6-4-8-22-16)21(24-17)28-12-13-9-19(25)23-11-13/h3-8,10,13H,9,11-12H2,1-2H3,(H,23,25)/t13-/m1/s1
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n/an/a 7.94E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144572
PNG
(US8969568, 125)
Show SMILES C[C@H](Oc1nc(cc2ncccc12)-c1ccccc1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C20H19N3O2/c1-13(15-10-19(24)22-12-15)25-20-16-8-5-9-21-18(16)11-17(23-20)14-6-3-2-4-7-14/h2-9,11,13,15H,10,12H2,1H3,(H,22,24)/t13-,15+/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144574
PNG
(US8969568, 127)
Show SMILES C[C@@H](Oc1nccc2ncccc12)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C14H15N3O2/c1-9(10-7-13(18)17-8-10)19-14-11-3-2-5-15-12(11)4-6-16-14/h2-6,9-10H,7-8H2,1H3,(H,17,18)/t9-,10-/m1/s1
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n/an/a 2.16E+6n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%