Compile Data Set for Download or QSAR

Found 113 hits with Last Name = 'zaczek' and Initial = 'rc'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM50182403 ((2R,3S)-N1-((S)-1-(3-phenoxybenzyl)-2-oxoazepan-3-...) Show SMILES CCC[C@@H]([C@@H](CC(C)C)C(=O)N[C@H]1CCCCN(Cc2cccc(Oc3ccccc3)c2)C1=O)C(=O)NO Show InChI InChI=1S/C30H41N3O5/c1-4-11-25(29(35)32-37)26(18-21(2)3)28(34)31-27-16-8-9-17-33(30(27)36)20-22-12-10-15-24(19-22)38-23-13-6-5-7-14-23/h5-7,10,12-15,19,21,25-27,37H,4,8-9,11,16-18,20H2,1-3H3,(H,31,34)(H,32,35)/t25-,26+,27-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of TACE				Bioorg Med Chem Lett 16: 2357-63 (2006) Article DOI: 10.1016/j.bmcl.2006.01.055 BindingDB Entry DOI: 10.7270/Q2WD405K
					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50182403 ((2R,3S)-N1-((S)-1-(3-phenoxybenzyl)-2-oxoazepan-3-...) Show SMILES CCC[C@@H]([C@@H](CC(C)C)C(=O)N[C@H]1CCCCN(Cc2cccc(Oc3ccccc3)c2)C1=O)C(=O)NO Show InChI InChI=1S/C30H41N3O5/c1-4-11-25(29(35)32-37)26(18-21(2)3)28(34)31-27-16-8-9-17-33(30(27)36)20-22-12-10-15-24(19-22)38-23-13-6-5-7-14-23/h5-7,10,12-15,19,21,25-27,37H,4,8-9,11,16-18,20H2,1-3H3,(H,31,34)(H,32,35)/t25-,26+,27-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of MMP9				Bioorg Med Chem Lett 16: 2357-63 (2006) Article DOI: 10.1016/j.bmcl.2006.01.055 BindingDB Entry DOI: 10.7270/Q2WD405K
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50182403 ((2R,3S)-N1-((S)-1-(3-phenoxybenzyl)-2-oxoazepan-3-...) Show SMILES CCC[C@@H]([C@@H](CC(C)C)C(=O)N[C@H]1CCCCN(Cc2cccc(Oc3ccccc3)c2)C1=O)C(=O)NO Show InChI InChI=1S/C30H41N3O5/c1-4-11-25(29(35)32-37)26(18-21(2)3)28(34)31-27-16-8-9-17-33(30(27)36)20-22-12-10-15-24(19-22)38-23-13-6-5-7-14-23/h5-7,10,12-15,19,21,25-27,37H,4,8-9,11,16-18,20H2,1-3H3,(H,31,34)(H,32,35)/t25-,26+,27-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of MMP2				Bioorg Med Chem Lett 16: 2357-63 (2006) Article DOI: 10.1016/j.bmcl.2006.01.055 BindingDB Entry DOI: 10.7270/Q2WD405K
					More data for this Ligand-Target Pair
Collagenase 3 (Homo sapiens (Human))	BDBM50182403 ((2R,3S)-N1-((S)-1-(3-phenoxybenzyl)-2-oxoazepan-3-...) Show SMILES CCC[C@@H]([C@@H](CC(C)C)C(=O)N[C@H]1CCCCN(Cc2cccc(Oc3ccccc3)c2)C1=O)C(=O)NO Show InChI InChI=1S/C30H41N3O5/c1-4-11-25(29(35)32-37)26(18-21(2)3)28(34)31-27-16-8-9-17-33(30(27)36)20-22-12-10-15-24(19-22)38-23-13-6-5-7-14-23/h5-7,10,12-15,19,21,25-27,37H,4,8-9,11,16-18,20H2,1-3H3,(H,31,34)(H,32,35)/t25-,26+,27-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of MMP13				Bioorg Med Chem Lett 16: 2357-63 (2006) Article DOI: 10.1016/j.bmcl.2006.01.055 BindingDB Entry DOI: 10.7270/Q2WD405K
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50074364 (CHEMBL350356 | N*2*-(2-Bromo-4-isopropyl-phenyl)-N...) Show SMILES CCCCN(CC)c1cc(C)nc(n1)N(CC)c1ccc(cc1Br)C(C)C Show InChI InChI=1S/C22H33BrN4/c1-7-10-13-26(8-2)21-14-17(6)24-22(25-21)27(9-3)20-12-11-18(16(4)5)15-19(20)23/h11-12,14-16H,7-10,13H2,1-6H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	18	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of [125I]-ovine-CRF binding to corticotropin releasing factor receptor 1				J Med Chem 47: 5783-90 (2004) Article DOI: 10.1021/jm049737f BindingDB Entry DOI: 10.7270/Q2S75FT6
					More data for this Ligand-Target Pair
Interstitial collagenase (Homo sapiens (Human))	BDBM50182403 ((2R,3S)-N1-((S)-1-(3-phenoxybenzyl)-2-oxoazepan-3-...) Show SMILES CCC[C@@H]([C@@H](CC(C)C)C(=O)N[C@H]1CCCCN(Cc2cccc(Oc3ccccc3)c2)C1=O)C(=O)NO Show InChI InChI=1S/C30H41N3O5/c1-4-11-25(29(35)32-37)26(18-21(2)3)28(34)31-27-16-8-9-17-33(30(27)36)20-22-12-10-15-24(19-22)38-23-13-6-5-7-14-23/h5-7,10,12-15,19,21,25-27,37H,4,8-9,11,16-18,20H2,1-3H3,(H,31,34)(H,32,35)/t25-,26+,27-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	21	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of MMP1				Bioorg Med Chem Lett 16: 2357-63 (2006) Article DOI: 10.1016/j.bmcl.2006.01.055 BindingDB Entry DOI: 10.7270/Q2WD405K
					More data for this Ligand-Target Pair
Stromelysin-2 (Homo sapiens (Human))	BDBM50182403 ((2R,3S)-N1-((S)-1-(3-phenoxybenzyl)-2-oxoazepan-3-...) Show SMILES CCC[C@@H]([C@@H](CC(C)C)C(=O)N[C@H]1CCCCN(Cc2cccc(Oc3ccccc3)c2)C1=O)C(=O)NO Show InChI InChI=1S/C30H41N3O5/c1-4-11-25(29(35)32-37)26(18-21(2)3)28(34)31-27-16-8-9-17-33(30(27)36)20-22-12-10-15-24(19-22)38-23-13-6-5-7-14-23/h5-7,10,12-15,19,21,25-27,37H,4,8-9,11,16-18,20H2,1-3H3,(H,31,34)(H,32,35)/t25-,26+,27-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	190	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of MMP10				Bioorg Med Chem Lett 16: 2357-63 (2006) Article DOI: 10.1016/j.bmcl.2006.01.055 BindingDB Entry DOI: 10.7270/Q2WD405K
					More data for this Ligand-Target Pair
Matrilysin (Homo sapiens (Human))	BDBM50182403 ((2R,3S)-N1-((S)-1-(3-phenoxybenzyl)-2-oxoazepan-3-...) Show SMILES CCC[C@@H]([C@@H](CC(C)C)C(=O)N[C@H]1CCCCN(Cc2cccc(Oc3ccccc3)c2)C1=O)C(=O)NO Show InChI InChI=1S/C30H41N3O5/c1-4-11-25(29(35)32-37)26(18-21(2)3)28(34)31-27-16-8-9-17-33(30(27)36)20-22-12-10-15-24(19-22)38-23-13-6-5-7-14-23/h5-7,10,12-15,19,21,25-27,37H,4,8-9,11,16-18,20H2,1-3H3,(H,31,34)(H,32,35)/t25-,26+,27-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	660	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of MMP7				Bioorg Med Chem Lett 16: 2357-63 (2006) Article DOI: 10.1016/j.bmcl.2006.01.055 BindingDB Entry DOI: 10.7270/Q2WD405K
					More data for this Ligand-Target Pair
Matrix metalloproteinase-14 (Homo sapiens (Human))	BDBM50182403 ((2R,3S)-N1-((S)-1-(3-phenoxybenzyl)-2-oxoazepan-3-...) Show SMILES CCC[C@@H]([C@@H](CC(C)C)C(=O)N[C@H]1CCCCN(Cc2cccc(Oc3ccccc3)c2)C1=O)C(=O)NO Show InChI InChI=1S/C30H41N3O5/c1-4-11-25(29(35)32-37)26(18-21(2)3)28(34)31-27-16-8-9-17-33(30(27)36)20-22-12-10-15-24(19-22)38-23-13-6-5-7-14-23/h5-7,10,12-15,19,21,25-27,37H,4,8-9,11,16-18,20H2,1-3H3,(H,31,34)(H,32,35)/t25-,26+,27-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of MMP14				Bioorg Med Chem Lett 16: 2357-63 (2006) Article DOI: 10.1016/j.bmcl.2006.01.055 BindingDB Entry DOI: 10.7270/Q2WD405K
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM50155982 (8-(Butyl-ethyl-amino)-4-(2-chloro-4-methoxy-phenyl...) Show SMILES CCCCN(CC)c1cc(C)nc2N(CC(=O)Nc12)c1ccc(OC)cc1Cl Show InChI InChI=1S/C21H27ClN4O2/c1-5-7-10-25(6-2)18-11-14(3)23-21-20(18)24-19(27)13-26(21)17-9-8-15(28-4)12-16(17)22/h8-9,11-12H,5-7,10,13H2,1-4H3,(H,24,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of [125I]-ovine-CRF binding to corticotropin releasing factor receptor 1				J Med Chem 47: 5783-90 (2004) Article DOI: 10.1021/jm049737f BindingDB Entry DOI: 10.7270/Q2S75FT6
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM50155974 (8-(Butyl-ethyl-amino)-4-(2,4-dichloro-phenyl)-6-me...) Show SMILES CCCCN(CC)c1cc(C)nc2N(CC(=O)Nc12)c1ccc(Cl)cc1Cl Show InChI InChI=1S/C20H24Cl2N4O/c1-4-6-9-25(5-2)17-10-13(3)23-20-19(17)24-18(27)12-26(20)16-8-7-14(21)11-15(16)22/h7-8,10-11H,4-6,9,12H2,1-3H3,(H,24,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.490	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of [125I]-ovine-CRF binding to corticotropin releasing factor receptor 1				J Med Chem 47: 5783-90 (2004) Article DOI: 10.1021/jm049737f BindingDB Entry DOI: 10.7270/Q2S75FT6
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM50155964 (8-(Butyl-ethyl-amino)-4-(2-chloro-5-fluoro-4-metho...) Show SMILES CCCCN(CC)c1cc(C)nc2N(CC(=O)Nc12)c1cc(F)c(OC)cc1Cl Show InChI InChI=1S/C21H26ClFN4O2/c1-5-7-8-26(6-2)17-9-13(3)24-21-20(17)25-19(28)12-27(21)16-11-15(23)18(29-4)10-14(16)22/h9-11H,5-8,12H2,1-4H3,(H,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of [125I]-ovine-CRF binding to corticotropin releasing factor receptor 1				J Med Chem 47: 5783-90 (2004) Article DOI: 10.1021/jm049737f BindingDB Entry DOI: 10.7270/Q2S75FT6
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM50387635 (CHEMBL2058338) Show SMILES CCC(C1CC1)n1c2nccc(-c3cc(C)c(OC)cc3Cl)c2nc(C)c1=O Show InChI InChI=1S/C22H24ClN3O2/c1-5-18(14-6-7-14)26-21-20(25-13(3)22(26)27)15(8-9-24-21)16-10-12(2)19(28-4)11-17(16)23/h8-11,14,18H,5-7H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.680	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co Curated by ChEMBL					Assay Description Antagonist activity at rat CFR1R				Bioorg Med Chem Lett 22: 4986-9 (2012) Article DOI: 10.1016/j.bmcl.2012.06.034 BindingDB Entry DOI: 10.7270/Q23X87Q6
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM50155967 (4-(2-Bromo-4-isopropyl-phenyl)-8-(butyl-ethyl-amin...) Show SMILES CCCCN(CC)c1cc(C)nc2N(CC(=O)Nc12)c1ccc(cc1Br)C(C)C Show InChI InChI=1S/C23H31BrN4O/c1-6-8-11-27(7-2)20-12-16(5)25-23-22(20)26-21(29)14-28(23)19-10-9-17(15(3)4)13-18(19)24/h9-10,12-13,15H,6-8,11,14H2,1-5H3,(H,26,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of [125I]-ovine-CRF binding to corticotropin releasing factor receptor 1				J Med Chem 47: 5783-90 (2004) Article DOI: 10.1021/jm049737f BindingDB Entry DOI: 10.7270/Q2S75FT6
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM50387601 (CHEMBL2058596) Show SMILES CCC(C1CC1)n1c2nccc(-c3cc(F)c(cc3Cl)N(C)C)c2nc(C)c1=O Show InChI InChI=1S/C22H24ClFN4O/c1-5-18(13-6-7-13)28-21-20(26-12(2)22(28)29)14(8-9-25-21)15-10-17(24)19(27(3)4)11-16(15)23/h8-11,13,18H,5-7H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.820	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co Curated by ChEMBL					Assay Description Antagonist activity at rat CFR1R				Bioorg Med Chem Lett 22: 4986-9 (2012) Article DOI: 10.1016/j.bmcl.2012.06.034 BindingDB Entry DOI: 10.7270/Q23X87Q6
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM20977 (8-[butyl(ethyl)amino]-4-(2,6-dimethoxypyridin-3-yl...) Show SMILES CCCCN(CC)c1cc(C)nc2N(CC(=O)Nc12)c1ccc(OC)nc1OC Show InChI InChI=1S/C21H29N5O3/c1-6-8-11-25(7-2)16-12-14(3)22-20-19(16)23-17(27)13-26(20)15-9-10-18(28-4)24-21(15)29-5/h9-10,12H,6-8,11,13H2,1-5H3,(H,23,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.820	n/a	n/a	n/a	n/a	7.0	23
Bristol-Myers Squibb Company					Assay Description The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.				J Med Chem 50: 2269-72 (2007) Article DOI: 10.1021/jm0611410 BindingDB Entry DOI: 10.7270/Q25Q4TCS
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM20977 (8-[butyl(ethyl)amino]-4-(2,6-dimethoxypyridin-3-yl...) Show SMILES CCCCN(CC)c1cc(C)nc2N(CC(=O)Nc12)c1ccc(OC)nc1OC Show InChI InChI=1S/C21H29N5O3/c1-6-8-11-25(7-2)16-12-14(3)22-20-19(16)23-17(27)13-26(20)15-9-10-18(28-4)24-21(15)29-5/h9-10,12H,6-8,11,13H2,1-5H3,(H,23,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.820	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of [125I]-ovine-CRF binding to corticotropin releasing factor receptor 1				J Med Chem 47: 5783-90 (2004) Article DOI: 10.1021/jm049737f BindingDB Entry DOI: 10.7270/Q2S75FT6
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM50155979 (8-(Butyl-ethyl-amino)-4-(2-chloro-4-isopropyl-phen...) Show SMILES CCCCN(CC)c1cc(C)nc2N(CC(=O)Nc12)c1ccc(cc1Cl)C(C)C Show InChI InChI=1S/C23H31ClN4O/c1-6-8-11-27(7-2)20-12-16(5)25-23-22(20)26-21(29)14-28(23)19-10-9-17(15(3)4)13-18(19)24/h9-10,12-13,15H,6-8,11,14H2,1-5H3,(H,26,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.910	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of [125I]-ovine-CRF binding to corticotropin releasing factor receptor 1				J Med Chem 47: 5783-90 (2004) Article DOI: 10.1021/jm049737f BindingDB Entry DOI: 10.7270/Q2S75FT6
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM20973 (8-[butyl(ethyl)amino]-4-(4-methoxy-2-methylphenyl)...) Show SMILES CCCCN(CC)c1cc(C)nc2N(CC(=O)Nc12)c1ccc(OC)cc1C Show InChI InChI=1S/C22H30N4O2/c1-6-8-11-25(7-2)19-13-16(4)23-22-21(19)24-20(27)14-26(22)18-10-9-17(28-5)12-15(18)3/h9-10,12-13H,6-8,11,14H2,1-5H3,(H,24,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.920	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of [125I]-ovine-CRF binding to corticotropin releasing factor receptor 1				J Med Chem 47: 5783-90 (2004) Article DOI: 10.1021/jm049737f BindingDB Entry DOI: 10.7270/Q2S75FT6
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM20973 (8-[butyl(ethyl)amino]-4-(4-methoxy-2-methylphenyl)...) Show SMILES CCCCN(CC)c1cc(C)nc2N(CC(=O)Nc12)c1ccc(OC)cc1C Show InChI InChI=1S/C22H30N4O2/c1-6-8-11-25(7-2)19-13-16(4)23-22-21(19)24-20(27)14-26(22)18-10-9-17(28-5)12-15(18)3/h9-10,12-13H,6-8,11,14H2,1-5H3,(H,24,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.920	n/a	n/a	n/a	n/a	7.0	23
Bristol-Myers Squibb Company					Assay Description The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.				J Med Chem 50: 2269-72 (2007) Article DOI: 10.1021/jm0611410 BindingDB Entry DOI: 10.7270/Q25Q4TCS
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM50387603 (CHEMBL2058598) Show SMILES CCC(C1CC1)n1c2nccc(-c3cc(C)c(Cl)cc3OC)c2nc(C)c1=O Show InChI InChI=1S/C22H24ClN3O2/c1-5-18(14-6-7-14)26-21-20(25-13(3)22(26)27)15(8-9-24-21)16-10-12(2)17(23)11-19(16)28-4/h8-11,14,18H,5-7H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co Curated by ChEMBL					Assay Description Antagonist activity at rat CFR1R				Bioorg Med Chem Lett 22: 4986-9 (2012) Article DOI: 10.1016/j.bmcl.2012.06.034 BindingDB Entry DOI: 10.7270/Q23X87Q6
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM50155975 (3-Chloro-4-(8-dipropylamino-6-methyl-2-oxo-2,3-dih...) Show SMILES CCCN(CCC)c1cc(C)nc2N(CC(=O)Nc12)c1ccc(cc1Cl)C#N Show InChI InChI=1S/C21H24ClN5O/c1-4-8-26(9-5-2)18-10-14(3)24-21-20(18)25-19(28)13-27(21)17-7-6-15(12-23)11-16(17)22/h6-7,10-11H,4-5,8-9,13H2,1-3H3,(H,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of [125I]-ovine-CRF binding to corticotropin releasing factor receptor 1				J Med Chem 47: 5783-90 (2004) Article DOI: 10.1021/jm049737f BindingDB Entry DOI: 10.7270/Q2S75FT6
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM50155973 (4-(2-Chloro-5-fluoro-4-methoxy-phenyl)-8-(ethyl-is...) Show SMILES CCN(C(C)C)c1cc(C)nc2N(CC(=O)Nc12)c1cc(F)c(OC)cc1Cl Show InChI InChI=1S/C20H24ClFN4O2/c1-6-25(11(2)3)16-7-12(4)23-20-19(16)24-18(27)10-26(20)15-9-14(22)17(28-5)8-13(15)21/h7-9,11H,6,10H2,1-5H3,(H,24,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of [125I]-ovine-CRF binding to corticotropin releasing factor receptor 1				J Med Chem 47: 5783-90 (2004) Article DOI: 10.1021/jm049737f BindingDB Entry DOI: 10.7270/Q2S75FT6
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM50387618 (CHEMBL2057479) Show SMILES COCC(C1CC1)n1c2nccc(-c3cc(F)c(OC)cc3Cl)c2nc(C)c1=O Show InChI InChI=1S/C21H21ClFN3O3/c1-11-21(27)26(17(10-28-2)12-4-5-12)20-19(25-11)13(6-7-24-20)14-8-16(23)18(29-3)9-15(14)22/h6-9,12,17H,4-5,10H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co Curated by ChEMBL					Assay Description Antagonist activity at rat CFR1R				Bioorg Med Chem Lett 22: 4986-9 (2012) Article DOI: 10.1016/j.bmcl.2012.06.034 BindingDB Entry DOI: 10.7270/Q23X87Q6
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM50387639 (CHEMBL2058593) Show SMILES CC[C@H](C1CC1)n1c2nccc(-c3cc(F)c(OC)cc3Cl)c2nc(C)c1=O |r| Show InChI InChI=1S/C21H21ClFN3O2/c1-4-17(12-5-6-12)26-20-19(25-11(2)21(26)27)13(7-8-24-20)14-9-16(23)18(28-3)10-15(14)22/h7-10,12,17H,4-6H2,1-3H3/t17-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co Curated by ChEMBL					Assay Description Antagonist activity at rat CFR1R				Bioorg Med Chem Lett 22: 4986-9 (2012) Article DOI: 10.1016/j.bmcl.2012.06.034 BindingDB Entry DOI: 10.7270/Q23X87Q6
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM50155960 (3-Chloro-4-[8-(cyclobutylmethyl-propyl-amino)-6-me...) Show SMILES CCCN(CC1CCC1)c1cc(C)nc2N(CC(=O)Nc12)c1ccc(cc1Cl)C#N Show InChI InChI=1S/C23H26ClN5O/c1-3-9-28(13-16-5-4-6-16)20-10-15(2)26-23-22(20)27-21(30)14-29(23)19-8-7-17(12-25)11-18(19)24/h7-8,10-11,16H,3-6,9,13-14H2,1-2H3,(H,27,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of [125I]-ovine-CRF binding to corticotropin releasing factor receptor 1				J Med Chem 47: 5783-90 (2004) Article DOI: 10.1021/jm049737f BindingDB Entry DOI: 10.7270/Q2S75FT6
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM50387636 (CHEMBL2058589) Show SMILES CCOc1cc(Cl)c(cc1C)-c1ccnc2n(C(CC)C3CC3)c(=O)c(C)nc12 Show InChI InChI=1S/C23H26ClN3O2/c1-5-19(15-7-8-15)27-22-21(26-14(4)23(27)28)16(9-10-25-22)17-11-13(3)20(29-6-2)12-18(17)24/h9-12,15,19H,5-8H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co Curated by ChEMBL					Assay Description Antagonist activity at rat CFR1R				Bioorg Med Chem Lett 22: 4986-9 (2012) Article DOI: 10.1016/j.bmcl.2012.06.034 BindingDB Entry DOI: 10.7270/Q23X87Q6
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM50387617 (CHEMBL2057478) Show SMILES CCC(COC)n1c2nccc(-c3cc(F)c(OC)cc3Cl)c2nc(C)c1=O Show InChI InChI=1S/C20H21ClFN3O3/c1-5-12(10-27-3)25-19-18(24-11(2)20(25)26)13(6-7-23-19)14-8-16(22)17(28-4)9-15(14)21/h6-9,12H,5,10H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co Curated by ChEMBL					Assay Description Antagonist activity at rat CFR1R				Bioorg Med Chem Lett 22: 4986-9 (2012) Article DOI: 10.1016/j.bmcl.2012.06.034 BindingDB Entry DOI: 10.7270/Q23X87Q6
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM20978 (N-butyl-4-(2,6-dimethoxypyridin-3-yl)-N-ethyl-6-me...) Show SMILES CCCCN(CC)c1cc(C)nc2N(CCNc12)c1ccc(OC)nc1OC Show InChI InChI=1S/C21H31N5O2/c1-6-8-12-25(7-2)17-14-15(3)23-20-19(17)22-11-13-26(20)16-9-10-18(27-4)24-21(16)28-5/h9-10,14,22H,6-8,11-13H2,1-5H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20	n/a	n/a	n/a	n/a	7.0	23
Bristol-Myers Squibb Company					Assay Description The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.				J Med Chem 50: 2269-72 (2007) Article DOI: 10.1021/jm0611410 BindingDB Entry DOI: 10.7270/Q25Q4TCS
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM50155959 (4-[8-(Butyl-ethyl-amino)-6-methyl-2-oxo-2,3-dihydr...) Show SMILES CCCCN(CC)c1cc(C)nc2N(CC(=O)Nc12)c1ccc(cc1Cl)C#N Show InChI InChI=1S/C21H24ClN5O/c1-4-6-9-26(5-2)18-10-14(3)24-21-20(18)25-19(28)13-27(21)17-8-7-15(12-23)11-16(17)22/h7-8,10-11H,4-6,9,13H2,1-3H3,(H,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of [125I]-ovine-CRF binding to corticotropin releasing factor receptor 1				J Med Chem 47: 5783-90 (2004) Article DOI: 10.1021/jm049737f BindingDB Entry DOI: 10.7270/Q2S75FT6
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM50155965 (4-(2-Chloro-4-isopropyl-phenyl)-8-[(2-methoxy-ethy...) Show SMILES CCCN(CCOC)c1cc(C)nc2N(CC(=O)Nc12)c1ccc(cc1Cl)C(C)C Show InChI InChI=1S/C23H31ClN4O2/c1-6-9-27(10-11-30-5)20-12-16(4)25-23-22(20)26-21(29)14-28(23)19-8-7-17(15(2)3)13-18(19)24/h7-8,12-13,15H,6,9-11,14H2,1-5H3,(H,26,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.60	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of [125I]-ovine-CRF binding to corticotropin releasing factor receptor 1				J Med Chem 47: 5783-90 (2004) Article DOI: 10.1021/jm049737f BindingDB Entry DOI: 10.7270/Q2S75FT6
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM50387616 (CHEMBL2057477) Show SMILES COc1ccc(c(C)c1)-c1ccnc2n(C(C3CC3)C3CC3)c(=O)c(C)nc12 Show InChI InChI=1S/C23H25N3O2/c1-13-12-17(28-3)8-9-18(13)19-10-11-24-22-20(19)25-14(2)23(27)26(22)21(15-4-5-15)16-6-7-16/h8-12,15-16,21H,4-7H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co Curated by ChEMBL					Assay Description Antagonist activity at rat CFR1R				Bioorg Med Chem Lett 22: 4986-9 (2012) Article DOI: 10.1016/j.bmcl.2012.06.034 BindingDB Entry DOI: 10.7270/Q23X87Q6
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM20985 (4-{8-[butyl(ethyl)amino]-6-methyl-2-oxo-1H,2H,3H,4...) Show SMILES CCCCN(CC)c1cc(C)nc2N(CC(=O)Nc12)c1ccc(cc1C)C#N Show InChI InChI=1S/C22H27N5O/c1-5-7-10-26(6-2)19-12-16(4)24-22-21(19)25-20(28)14-27(22)18-9-8-17(13-23)11-15(18)3/h8-9,11-12H,5-7,10,14H2,1-4H3,(H,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.30	n/a	n/a	n/a	n/a	7.0	23
Bristol-Myers Squibb Company					Assay Description The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.				J Med Chem 50: 2269-72 (2007) Article DOI: 10.1021/jm0611410 BindingDB Entry DOI: 10.7270/Q25Q4TCS
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM50155977 (4-[8-(Butyl-ethyl-amino)-6-methyl-2-oxo-2,3-dihydr...) Show SMILES CCCCN(CC)c1cc(C)nc2N(CC(=O)Nc12)c1c(Cl)cc(cc1Cl)C#N Show InChI InChI=1S/C21H23Cl2N5O/c1-4-6-7-27(5-2)17-8-13(3)25-21-19(17)26-18(29)12-28(21)20-15(22)9-14(11-24)10-16(20)23/h8-10H,4-7,12H2,1-3H3,(H,26,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of [125I]-ovine-CRF binding to corticotropin releasing factor receptor 1				J Med Chem 47: 5783-90 (2004) Article DOI: 10.1021/jm049737f BindingDB Entry DOI: 10.7270/Q2S75FT6
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM50387604 (CHEMBL2058599) Show SMILES CCC(C1CC1)n1c2nccc(-c3cc(Cl)c(OC)cc3OC)c2nc(C)c1=O Show InChI InChI=1S/C22H24ClN3O3/c1-5-17(13-6-7-13)26-21-20(25-12(2)22(26)27)14(8-9-24-21)15-10-16(23)19(29-4)11-18(15)28-3/h8-11,13,17H,5-7H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co Curated by ChEMBL					Assay Description Antagonist activity at rat CFR1R				Bioorg Med Chem Lett 22: 4986-9 (2012) Article DOI: 10.1016/j.bmcl.2012.06.034 BindingDB Entry DOI: 10.7270/Q23X87Q6
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM20986 (4-{8-[butyl(ethyl)amino]-6-methyl-1H,2H,3H,4H-pyri...) Show SMILES CCCCN(CC)c1cc(C)nc2N(CCNc12)c1ccc(cc1C)C#N Show InChI InChI=1S/C22H29N5/c1-5-7-11-26(6-2)20-14-17(4)25-22-21(20)24-10-12-27(22)19-9-8-18(15-23)13-16(19)3/h8-9,13-14,24H,5-7,10-12H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.5	n/a	n/a	n/a	n/a	7.0	23
Bristol-Myers Squibb Company					Assay Description The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.				J Med Chem 50: 2269-72 (2007) Article DOI: 10.1021/jm0611410 BindingDB Entry DOI: 10.7270/Q25Q4TCS
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM50387633 (CHEMBL2058336) Show SMILES CC[C@@H](C1CC1)n1c2nccc(-c3ccc(OC)cc3Cl)c2nc(C)c1=O |r| Show InChI InChI=1S/C21H22ClN3O2/c1-4-18(13-5-6-13)25-20-19(24-12(2)21(25)26)16(9-10-23-20)15-8-7-14(27-3)11-17(15)22/h7-11,13,18H,4-6H2,1-3H3/t18-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co Curated by ChEMBL					Assay Description Antagonist activity at rat CFR1R				Bioorg Med Chem Lett 22: 4986-9 (2012) Article DOI: 10.1016/j.bmcl.2012.06.034 BindingDB Entry DOI: 10.7270/Q23X87Q6
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM50387626 (CHEMBL2058329) Show SMILES CC[C@H](COC)n1c2nccc(-c3ccc(Cl)cc3Cl)c2nc(C)c1=O |r| Show InChI InChI=1S/C19H19Cl2N3O2/c1-4-13(10-26-3)24-18-17(23-11(2)19(24)25)15(7-8-22-18)14-6-5-12(20)9-16(14)21/h5-9,13H,4,10H2,1-3H3/t13-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co Curated by ChEMBL					Assay Description Antagonist activity at rat CFR1R				Bioorg Med Chem Lett 22: 4986-9 (2012) Article DOI: 10.1016/j.bmcl.2012.06.034 BindingDB Entry DOI: 10.7270/Q23X87Q6
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM50155966 (4-(2-Bromo-4-isopropyl-phenyl)-8-(ethyl-furan-2-yl...) Show SMILES CCN(Cc1ccco1)c1cc(C)nc2N(CC(=O)Nc12)c1ccc(cc1Br)C(C)C Show InChI InChI=1S/C24H27BrN4O2/c1-5-28(13-18-7-6-10-31-18)21-11-16(4)26-24-23(21)27-22(30)14-29(24)20-9-8-17(15(2)3)12-19(20)25/h6-12,15H,5,13-14H2,1-4H3,(H,27,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.10	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of [125I]-ovine-CRF binding to corticotropin releasing factor receptor 1				J Med Chem 47: 5783-90 (2004) Article DOI: 10.1021/jm049737f BindingDB Entry DOI: 10.7270/Q2S75FT6
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM50155961 (8-(Butyl-ethyl-amino)-4-(6-methoxy-2-methyl-pyridi...) Show SMILES CCCCN(CC)c1cc(C)nc2N(CC(=O)Nc12)c1ccc(OC)nc1C Show InChI InChI=1S/C21H29N5O2/c1-6-8-11-25(7-2)17-12-14(3)22-21-20(17)24-18(27)13-26(21)16-9-10-19(28-5)23-15(16)4/h9-10,12H,6-8,11,13H2,1-5H3,(H,24,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of [125I]-ovine-CRF binding to corticotropin releasing factor receptor 1				J Med Chem 47: 5783-90 (2004) Article DOI: 10.1021/jm049737f BindingDB Entry DOI: 10.7270/Q2S75FT6
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM20974 (N-butyl-N-ethyl-4-(4-methoxy-2-methylphenyl)-6-met...) Show SMILES CCCCN(CC)c1cc(C)nc2N(CCNc12)c1ccc(OC)cc1C Show InChI InChI=1S/C22H32N4O/c1-6-8-12-25(7-2)20-15-17(4)24-22-21(20)23-11-13-26(22)19-10-9-18(27-5)14-16(19)3/h9-10,14-15,23H,6-8,11-13H2,1-5H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.20	n/a	n/a	n/a	n/a	7.0	23
Bristol-Myers Squibb Company					Assay Description The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.				J Med Chem 50: 2269-72 (2007) Article DOI: 10.1021/jm0611410 BindingDB Entry DOI: 10.7270/Q25Q4TCS
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM50387624 (CHEMBL2058327) Show SMILES CCCC(C1CC1)n1c2nccc(-c3ccc(Cl)cc3Cl)c2nc(C)c1=O Show InChI InChI=1S/C21H21Cl2N3O/c1-3-4-18(13-5-6-13)26-20-19(25-12(2)21(26)27)16(9-10-24-20)15-8-7-14(22)11-17(15)23/h7-11,13,18H,3-6H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.30	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co Curated by ChEMBL					Assay Description Antagonist activity at rat CFR1R				Bioorg Med Chem Lett 22: 4986-9 (2012) Article DOI: 10.1016/j.bmcl.2012.06.034 BindingDB Entry DOI: 10.7270/Q23X87Q6
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM50387637 (CHEMBL2058591) Show SMILES CC[C@H](C1CC1)n1c2nccc(-c3cc(Cl)c(OC)cc3C)c2nc(C)c1=O |r| Show InChI InChI=1S/C22H24ClN3O2/c1-5-18(14-6-7-14)26-21-20(25-13(3)22(26)27)15(8-9-24-21)16-11-17(23)19(28-4)10-12(16)2/h8-11,14,18H,5-7H2,1-4H3/t18-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co Curated by ChEMBL					Assay Description Antagonist activity at rat CFR1R				Bioorg Med Chem Lett 22: 4986-9 (2012) Article DOI: 10.1016/j.bmcl.2012.06.034 BindingDB Entry DOI: 10.7270/Q23X87Q6
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM50387634 (CHEMBL2058337) Show SMILES CC[C@H](C1CC1)n1c2nccc(-c3ccc(OC)cc3Cl)c2nc(C)c1=O |r| Show InChI InChI=1S/C21H22ClN3O2/c1-4-18(13-5-6-13)25-20-19(24-12(2)21(25)26)16(9-10-23-20)15-8-7-14(27-3)11-17(15)22/h7-11,13,18H,4-6H2,1-3H3/t18-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co Curated by ChEMBL					Assay Description Antagonist activity at rat CFR1R				Bioorg Med Chem Lett 22: 4986-9 (2012) Article DOI: 10.1016/j.bmcl.2012.06.034 BindingDB Entry DOI: 10.7270/Q23X87Q6
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM50387602 (CHEMBL2058597) Show SMILES CCC(C1CC1)n1c2nccc(-c3cc(C#N)c(C)cc3Cl)c2nc(C)c1=O Show InChI InChI=1S/C22H21ClN4O/c1-4-19(14-5-6-14)27-21-20(26-13(3)22(27)28)16(7-8-25-21)17-10-15(11-24)12(2)9-18(17)23/h7-10,14,19H,4-6H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.80	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co Curated by ChEMBL					Assay Description Antagonist activity at rat CFR1R				Bioorg Med Chem Lett 22: 4986-9 (2012) Article DOI: 10.1016/j.bmcl.2012.06.034 BindingDB Entry DOI: 10.7270/Q23X87Q6
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM50387629 (CHEMBL2058332) Show SMILES CCC(C1CC1)n1c2nccc(-c3cc(C)c(C)cc3C)c2nc(C)c1=O Show InChI InChI=1S/C23H27N3O/c1-6-20(17-7-8-17)26-22-21(25-16(5)23(26)27)18(9-10-24-22)19-12-14(3)13(2)11-15(19)4/h9-12,17,20H,6-8H2,1-5H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.20	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co Curated by ChEMBL					Assay Description Antagonist activity at rat CFR1R				Bioorg Med Chem Lett 22: 4986-9 (2012) Article DOI: 10.1016/j.bmcl.2012.06.034 BindingDB Entry DOI: 10.7270/Q23X87Q6
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM20989 (8-[butyl(ethyl)amino]-4-(4-acetyl-2-methylphenyl)-...) Show SMILES CCCCN(CC)c1cc(C)nc2N(CC(=O)Nc12)c1ccc(cc1C)C(C)=O Show InChI InChI=1S/C23H30N4O2/c1-6-8-11-26(7-2)20-13-16(4)24-23-22(20)25-21(29)14-27(23)19-10-9-18(17(5)28)12-15(19)3/h9-10,12-13H,6-8,11,14H2,1-5H3,(H,25,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.80	n/a	n/a	n/a	n/a	7.0	23
Bristol-Myers Squibb Company					Assay Description The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.				J Med Chem 50: 2269-72 (2007) Article DOI: 10.1021/jm0611410 BindingDB Entry DOI: 10.7270/Q25Q4TCS
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM50155981 (4-(2-Bromo-phenyl)-8-(butyl-ethyl-amino)-6-methyl-...) Show SMILES CCCCN(CC)c1cc(C)nc2N(CC(=O)Nc12)c1ccccc1Br Show InChI InChI=1S/C20H25BrN4O/c1-4-6-11-24(5-2)17-12-14(3)22-20-19(17)23-18(26)13-25(20)16-10-8-7-9-15(16)21/h7-10,12H,4-6,11,13H2,1-3H3,(H,23,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.10	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of [125I]-ovine-CRF binding to corticotropin releasing factor receptor 1				J Med Chem 47: 5783-90 (2004) Article DOI: 10.1021/jm049737f BindingDB Entry DOI: 10.7270/Q2S75FT6
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM50387632 (CHEMBL2058335) Show SMILES CC[C@@H](C1CC1)n1c2nccc(-c3ccc(OC(F)F)cc3Cl)c2nc(C)c1=O |r| Show InChI InChI=1S/C21H20ClF2N3O2/c1-3-17(12-4-5-12)27-19-18(26-11(2)20(27)28)15(8-9-25-19)14-7-6-13(10-16(14)22)29-21(23)24/h6-10,12,17,21H,3-5H2,1-2H3/t17-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.30	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co Curated by ChEMBL					Assay Description Antagonist activity at rat CFR1R				Bioorg Med Chem Lett 22: 4986-9 (2012) Article DOI: 10.1016/j.bmcl.2012.06.034 BindingDB Entry DOI: 10.7270/Q23X87Q6
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM50387623 (CHEMBL2058326) Show SMILES CC[C@@H](C1CC1)n1c2nccc(-c3ccc(Cl)cc3Cl)c2nc(C)c1=O |r| Show InChI InChI=1S/C20H19Cl2N3O/c1-3-17(12-4-5-12)25-19-18(24-11(2)20(25)26)15(8-9-23-19)14-7-6-13(21)10-16(14)22/h6-10,12,17H,3-5H2,1-2H3/t17-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.40	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co Curated by ChEMBL					Assay Description Antagonist activity at rat CFR1R				Bioorg Med Chem Lett 22: 4986-9 (2012) Article DOI: 10.1016/j.bmcl.2012.06.034 BindingDB Entry DOI: 10.7270/Q23X87Q6
					More data for this Ligand-Target Pair

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