Compile Data Set for Download or QSAR

Found 97 hits of ic50 for UniProtKB: P06240   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus)	BDBM26166 (2,4-dianilino pyrimidine, 23 | 3-({4-[(5-hydroxy-2...) Show SMILES Cc1ccc(O)cc1Nc1ccnc(Nc2cccc(c2)S(N)(=O)=O)n1 Show InChI InChI=1S/C17H17N5O3S/c1-11-5-6-13(23)10-15(11)21-16-7-8-19-17(22-16)20-12-3-2-4-14(9-12)26(18,24)25/h2-10,23H,1H3,(H2,18,24,25)(H2,19,20,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.5	n/a	n/a	n/a	n/a	7.4	22
GSK					Assay Description Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...				Bioorg Med Chem Lett 17: 4363-8 (2007) Article DOI: 10.1016/j.bmcl.2007.04.029 BindingDB Entry DOI: 10.7270/Q21R6NTD
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus)	BDBM26180 (2,4-dianilino pyrimidine, 37 | 3-({4-[(5-methyl-1H...) Show SMILES Cc1ccc2[nH]ncc2c1Nc1ccnc(Nc2cccc(c2)C(N)=O)n1 Show InChI InChI=1S/C19H17N7O/c1-11-5-6-15-14(10-22-26-15)17(11)24-16-7-8-21-19(25-16)23-13-4-2-3-12(9-13)18(20)27/h2-10H,1H3,(H2,20,27)(H,22,26)(H2,21,23,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...				Bioorg Med Chem Lett 17: 4363-8 (2007) Article DOI: 10.1016/j.bmcl.2007.04.029 BindingDB Entry DOI: 10.7270/Q21R6NTD
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus)	BDBM26145 (2,4-dianilino pyrimidine, 2 | 3-({4-[(5-hydroxy-2-...) Show SMILES Cc1ccc(O)cc1Nc1ccnc(Nc2cccc(c2)C(N)=O)n1 Show InChI InChI=1S/C18H17N5O2/c1-11-5-6-14(24)10-15(11)22-16-7-8-20-18(23-16)21-13-4-2-3-12(9-13)17(19)25/h2-10,24H,1H3,(H2,19,25)(H2,20,21,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	7.4	22
GSK					Assay Description Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...				Bioorg Med Chem Lett 17: 4363-8 (2007) Article DOI: 10.1016/j.bmcl.2007.04.029 BindingDB Entry DOI: 10.7270/Q21R6NTD
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus)	BDBM26186 (2,4-dianilino pyrimidine, 43 | 3-({4-[(5-methyl-1H...) Show SMILES Cc1ccc2[nH]ncc2c1Nc1ccnc(Nc2cccc(c2)S(N)(=O)=O)n1 Show InChI InChI=1S/C18H17N7O2S/c1-11-5-6-15-14(10-21-25-15)17(11)23-16-7-8-20-18(24-16)22-12-3-2-4-13(9-12)28(19,26)27/h2-10H,1H3,(H,21,25)(H2,19,26,27)(H2,20,22,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...				Bioorg Med Chem Lett 17: 4363-8 (2007) Article DOI: 10.1016/j.bmcl.2007.04.029 BindingDB Entry DOI: 10.7270/Q21R6NTD
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus)	BDBM50142887 (1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...) Show SMILES CC(C)(C)n1nc(-c2ccc(Cl)cc2)c2c(N)ncnc12 Show InChI InChI=1S/C15H16ClN5/c1-15(2,3)21-14-11(13(17)18-8-19-14)12(20-21)9-4-6-10(16)7-5-9/h4-8H,1-3H3,(H2,17,18,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
University of Dundee Curated by ChEMBL					Assay Description Inhibition of Lck in the presence of 50uM ATP				Biochem J 408: 297-315 (2007) Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus)	BDBM26185 (2,4-dianilino pyrimidine, 42 | 3-{[4-(1H-indazol-4...) Show SMILES NS(=O)(=O)c1cccc(Nc2nccc(Nc3cccc4[nH]ncc34)n2)c1 Show InChI InChI=1S/C17H15N7O2S/c18-27(25,26)12-4-1-3-11(9-12)21-17-19-8-7-16(23-17)22-14-5-2-6-15-13(14)10-20-24-15/h1-10H,(H,20,24)(H2,18,25,26)(H2,19,21,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...				Bioorg Med Chem Lett 17: 4363-8 (2007) Article DOI: 10.1016/j.bmcl.2007.04.029 BindingDB Entry DOI: 10.7270/Q21R6NTD
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus)	BDBM25116 (1-tert-butyl-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]...) Show SMILES Cc1ccc(cc1)-c1nn(c2ncnc(N)c12)C(C)(C)C Show InChI InChI=1S/C16H19N5/c1-10-5-7-11(8-6-10)13-12-14(17)18-9-19-15(12)21(20-13)16(2,3)4/h5-9H,1-4H3,(H2,17,18,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
University of Dundee Curated by ChEMBL					Assay Description Inhibition of Lck in the presence of 50uM ATP				Biochem J 408: 297-315 (2007) Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus)	BDBM26152 (2,4-dianilino pyrimidine, 9 | 3-({4-[(4-hydroxy-2-...) Show SMILES Cc1cc(O)ccc1Nc1ccnc(Nc2cccc(c2)C(N)=O)n1 Show InChI InChI=1S/C18H17N5O2/c1-11-9-14(24)5-6-15(11)22-16-7-8-20-18(23-16)21-13-4-2-3-12(10-13)17(19)25/h2-10,24H,1H3,(H2,19,25)(H2,20,21,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	7.4	22
GSK					Assay Description Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...				Bioorg Med Chem Lett 17: 4363-8 (2007) Article DOI: 10.1016/j.bmcl.2007.04.029 BindingDB Entry DOI: 10.7270/Q21R6NTD
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus)	BDBM26149 (2,4-dianilino pyrimidine, 6 | 3-({4-[(2-bromo-5-hy...) Show SMILES NC(=O)c1cccc(Nc2nccc(Nc3cc(O)ccc3Br)n2)c1 Show InChI InChI=1S/C17H14BrN5O2/c18-13-5-4-12(24)9-14(13)22-15-6-7-20-17(23-15)21-11-3-1-2-10(8-11)16(19)25/h1-9,24H,(H2,19,25)(H2,20,21,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	41	n/a	n/a	n/a	n/a	7.4	22
GSK					Assay Description Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...				Bioorg Med Chem Lett 17: 4363-8 (2007) Article DOI: 10.1016/j.bmcl.2007.04.029 BindingDB Entry DOI: 10.7270/Q21R6NTD
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus)	BDBM26167 (2,4-dianilino pyrimidine, 24 | 3-({4-[(5-methoxy-2...) Show SMILES COc1ccc(C)c(Nc2ccnc(Nc3cccc(c3)S(N)(=O)=O)n2)c1 Show InChI InChI=1S/C18H19N5O3S/c1-12-6-7-14(26-2)11-16(12)22-17-8-9-20-18(23-17)21-13-4-3-5-15(10-13)27(19,24)25/h3-11H,1-2H3,(H2,19,24,25)(H2,20,21,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	54	n/a	n/a	n/a	n/a	7.4	22
GSK					Assay Description Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...				Bioorg Med Chem Lett 17: 4363-8 (2007) Article DOI: 10.1016/j.bmcl.2007.04.029 BindingDB Entry DOI: 10.7270/Q21R6NTD
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus)	BDBM26182 (2,4-dianilino pyrimidine, 39 | 3-({4-[(7-methyl-1H...) Show SMILES Cc1ccc(Nc2ccnc(Nc3cccc(c3)C(N)=O)n2)c2cn[nH]c12 Show InChI InChI=1S/C19H17N7O/c1-11-5-6-15(14-10-22-26-17(11)14)24-16-7-8-21-19(25-16)23-13-4-2-3-12(9-13)18(20)27/h2-10H,1H3,(H2,20,27)(H,22,26)(H2,21,23,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...				Bioorg Med Chem Lett 17: 4363-8 (2007) Article DOI: 10.1016/j.bmcl.2007.04.029 BindingDB Entry DOI: 10.7270/Q21R6NTD
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus)	BDBM25191 (4-{4-[(5-hydroxy-2-methylphenyl)amino]quinolin-7-y...) Show SMILES Cc1ccc(O)cc1Nc1ccnc2cc(ccc12)-c1csc(C=O)n1 Show InChI InChI=1S/C20H15N3O2S/c1-12-2-4-14(25)9-17(12)22-16-6-7-21-18-8-13(3-5-15(16)18)19-11-26-20(10-24)23-19/h2-11,25H,1H3,(H,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	DrugBank MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	20	-10.4	59	n/a	n/a	n/a	n/a	7.4	22
GSK					Assay Description Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...				Bioorg Med Chem Lett 18: 318-23 (2008) Article DOI: 10.1016/j.bmcl.2007.10.076 BindingDB Entry DOI: 10.7270/Q2KP80G3
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus)	BDBM25191 (4-{4-[(5-hydroxy-2-methylphenyl)amino]quinolin-7-y...) Show SMILES Cc1ccc(O)cc1Nc1ccnc2cc(ccc12)-c1csc(C=O)n1 Show InChI InChI=1S/C20H15N3O2S/c1-12-2-4-14(25)9-17(12)22-16-6-7-21-18-8-13(3-5-15(16)18)19-11-26-20(10-24)23-19/h2-11,25H,1H3,(H,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	DrugBank MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	59	n/a	n/a	n/a	n/a	7.4	22
GSK					Assay Description Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...				Bioorg Med Chem Lett 17: 4363-8 (2007) Article DOI: 10.1016/j.bmcl.2007.04.029 BindingDB Entry DOI: 10.7270/Q21R6NTD
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus)	BDBM13242 (2-[(butylcarbamoyl)amino]-4-methyl-N-(2,4,6-trimet...) Show SMILES CCCCNC(=O)Nc1nc(C)c(s1)C(=O)Nc1c(C)cc(C)cc1C Show InChI InChI=1S/C19H26N4O2S/c1-6-7-8-20-18(25)23-19-21-14(5)16(26-19)17(24)22-15-12(3)9-11(2)10-13(15)4/h9-10H,6-8H2,1-5H3,(H,22,24)(H2,20,21,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description In vitro inhibition of murine Lck kinase.				Bioorg Med Chem Lett 13: 4007-10 (2003) BindingDB Entry DOI: 10.7270/Q2CC103J
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus)	BDBM13242 (2-[(butylcarbamoyl)amino]-4-methyl-N-(2,4,6-trimet...) Show SMILES CCCCNC(=O)Nc1nc(C)c(s1)C(=O)Nc1c(C)cc(C)cc1C Show InChI InChI=1S/C19H26N4O2S/c1-6-7-8-20-18(25)23-19-21-14(5)16(26-19)17(24)22-15-12(3)9-11(2)10-13(15)4/h9-10H,6-8H2,1-5H3,(H,22,24)(H2,20,21,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...				J Med Chem 49: 6819-32 (2006) Article DOI: 10.1021/jm060727j BindingDB Entry DOI: 10.7270/Q2QN6501
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus)	BDBM26147 (2,4-dianilino pyrimidine, 4 | 3-({4-[(3-hydroxy-5-...) Show SMILES Cc1cc(O)cc(Nc2ccnc(Nc3cccc(c3)C(N)=O)n2)c1 Show InChI InChI=1S/C18H17N5O2/c1-11-7-14(10-15(24)8-11)21-16-5-6-20-18(23-16)22-13-4-2-3-12(9-13)17(19)25/h2-10,24H,1H3,(H2,19,25)(H2,20,21,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	73	n/a	n/a	n/a	n/a	7.4	22
GSK					Assay Description Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...				Bioorg Med Chem Lett 17: 4363-8 (2007) Article DOI: 10.1016/j.bmcl.2007.04.029 BindingDB Entry DOI: 10.7270/Q21R6NTD
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus)	BDBM26156 (2,4-dianilino pyrimidine, 13 | 3-({4-[(5-methoxy-2...) Show SMILES COc1ccc(C)c(Nc2ccnc(Nc3cccc(c3)C(N)=O)n2)c1 Show InChI InChI=1S/C19H19N5O2/c1-12-6-7-15(26-2)11-16(12)23-17-8-9-21-19(24-17)22-14-5-3-4-13(10-14)18(20)25/h3-11H,1-2H3,(H2,20,25)(H2,21,22,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	86	n/a	n/a	n/a	n/a	7.4	22
GSK					Assay Description Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...				Bioorg Med Chem Lett 17: 4363-8 (2007) Article DOI: 10.1016/j.bmcl.2007.04.029 BindingDB Entry DOI: 10.7270/Q21R6NTD
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus)	BDBM26151 (2,4-dianilino pyrimidine, 8 | 3-({4-[(2-methylphen...) Show SMILES Cc1ccccc1Nc1ccnc(Nc2cccc(c2)C(N)=O)n1 Show InChI InChI=1S/C18H17N5O/c1-12-5-2-3-8-15(12)22-16-9-10-20-18(23-16)21-14-7-4-6-13(11-14)17(19)24/h2-11H,1H3,(H2,19,24)(H2,20,21,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	89	n/a	n/a	n/a	n/a	7.4	22
GSK					Assay Description Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...				Bioorg Med Chem Lett 17: 4363-8 (2007) Article DOI: 10.1016/j.bmcl.2007.04.029 BindingDB Entry DOI: 10.7270/Q21R6NTD
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus)	BDBM13241 (4-methyl-2-[(phenylcarbamoyl)amino]-N-(2,4,6-trime...) Show SMILES Cc1nc(NC(=O)Nc2ccccc2)sc1C(=O)Nc1c(C)cc(C)cc1C Show InChI InChI=1S/C21H22N4O2S/c1-12-10-13(2)17(14(3)11-12)24-19(26)18-15(4)22-21(28-18)25-20(27)23-16-8-6-5-7-9-16/h5-11H,1-4H3,(H,24,26)(H2,22,23,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...				J Med Chem 49: 6819-32 (2006) Article DOI: 10.1021/jm060727j BindingDB Entry DOI: 10.7270/Q2QN6501
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus)	BDBM26157 (2,4-dianilino pyrimidine, 14 | 3-({4-[(5-amino-2-m...) Show SMILES Cc1ccc(N)cc1Nc1ccnc(Nc2cccc(c2)C(N)=O)n1 Show InChI InChI=1S/C18H18N6O/c1-11-5-6-13(19)10-15(11)23-16-7-8-21-18(24-16)22-14-4-2-3-12(9-14)17(20)25/h2-10H,19H2,1H3,(H2,20,25)(H2,21,22,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	97	n/a	n/a	n/a	n/a	7.4	22
GSK					Assay Description Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...				Bioorg Med Chem Lett 17: 4363-8 (2007) Article DOI: 10.1016/j.bmcl.2007.04.029 BindingDB Entry DOI: 10.7270/Q21R6NTD
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus)	BDBM26153 (2,4-dianilino pyrimidine, 10 | 3-({4-[(2-hydroxy-6...) Show SMILES Cc1cccc(O)c1Nc1ccnc(Nc2cccc(c2)C(N)=O)n1 Show InChI InChI=1S/C18H17N5O2/c1-11-4-2-7-14(24)16(11)22-15-8-9-20-18(23-15)21-13-6-3-5-12(10-13)17(19)25/h2-10,24H,1H3,(H2,19,25)(H2,20,21,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	7.4	22
GSK					Assay Description Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...				Bioorg Med Chem Lett 17: 4363-8 (2007) Article DOI: 10.1016/j.bmcl.2007.04.029 BindingDB Entry DOI: 10.7270/Q21R6NTD
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus)	BDBM13244 (2-[(benzylcarbamoyl)amino]-4-methyl-N-(2,4,6-trime...) Show SMILES Cc1nc(NC(=O)NCc2ccccc2)sc1C(=O)Nc1c(C)cc(C)cc1C Show InChI InChI=1S/C22H24N4O2S/c1-13-10-14(2)18(15(3)11-13)25-20(27)19-16(4)24-22(29-19)26-21(28)23-12-17-8-6-5-7-9-17/h5-11H,12H2,1-4H3,(H,25,27)(H2,23,24,26,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...				J Med Chem 49: 6819-32 (2006) Article DOI: 10.1021/jm060727j BindingDB Entry DOI: 10.7270/Q2QN6501
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus)	BDBM26179 (2,4-dianilino pyrimidine, 36 | 3-{[4-(1H-indazol-4...) Show SMILES NC(=O)c1cccc(Nc2nccc(Nc3cccc4[nH]ncc34)n2)c1 Show InChI InChI=1S/C18H15N7O/c19-17(26)11-3-1-4-12(9-11)22-18-20-8-7-16(24-18)23-14-5-2-6-15-13(14)10-21-25-15/h1-10H,(H2,19,26)(H,21,25)(H2,20,22,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...				Bioorg Med Chem Lett 17: 4363-8 (2007) Article DOI: 10.1016/j.bmcl.2007.04.029 BindingDB Entry DOI: 10.7270/Q21R6NTD
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus)	BDBM26146 (2,4-dianilino pyrimidine, 3 | 3-({4-[(3-hydroxyphe...) Show SMILES NC(=O)c1cccc(Nc2nccc(Nc3cccc(O)c3)n2)c1 Show InChI InChI=1S/C17H15N5O2/c18-16(24)11-3-1-4-12(9-11)21-17-19-8-7-15(22-17)20-13-5-2-6-14(23)10-13/h1-10,23H,(H2,18,24)(H2,19,20,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	7.4	22
GSK					Assay Description Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...				Bioorg Med Chem Lett 17: 4363-8 (2007) Article DOI: 10.1016/j.bmcl.2007.04.029 BindingDB Entry DOI: 10.7270/Q21R6NTD
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus)	BDBM50307127 ((3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-I...) Show SMILES CN(C)S(=O)(=O)c1ccc2NC(=O)\C(=C/c3cc4CCCCc4[nH]3)c2c1 Show InChI InChI=1S/C19H21N3O3S/c1-22(2)26(24,25)14-7-8-18-15(11-14)16(19(23)21-18)10-13-9-12-5-3-4-6-17(12)20-13/h7-11,20H,3-6H2,1-2H3,(H,21,23)/b16-10-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
University of Dundee Curated by ChEMBL					Assay Description Inhibition of Lck in the presence of 50uM ATP				Biochem J 408: 297-315 (2007) Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus)	BDBM13240 (2-[[(Methylamino)-carbonyl]amino]-4-methyl-N-(2,4,...) Show SMILES CNC(=O)Nc1nc(C)c(s1)C(=O)Nc1c(C)cc(C)cc1C Show InChI InChI=1S/C16H20N4O2S/c1-8-6-9(2)12(10(3)7-8)19-14(21)13-11(4)18-16(23-13)20-15(22)17-5/h6-7H,1-5H3,(H,19,21)(H2,17,18,20,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description In vitro inhibition of murine Lck kinase.				Bioorg Med Chem Lett 13: 4007-10 (2003) BindingDB Entry DOI: 10.7270/Q2CC103J
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus)	BDBM13240 (2-[[(Methylamino)-carbonyl]amino]-4-methyl-N-(2,4,...) Show SMILES CNC(=O)Nc1nc(C)c(s1)C(=O)Nc1c(C)cc(C)cc1C Show InChI InChI=1S/C16H20N4O2S/c1-8-6-9(2)12(10(3)7-8)19-14(21)13-11(4)18-16(23-13)20-15(22)17-5/h6-7H,1-5H3,(H,19,21)(H2,17,18,20,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...				J Med Chem 49: 6819-32 (2006) Article DOI: 10.1021/jm060727j BindingDB Entry DOI: 10.7270/Q2QN6501
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus)	BDBM26148 (2,4-dianilino pyrimidine, 5 | 3-({4-[(3-hydroxy-4-...) Show SMILES Cc1ccc(Nc2ccnc(Nc3cccc(c3)C(N)=O)n2)cc1O Show InChI InChI=1S/C18H17N5O2/c1-11-5-6-14(10-15(11)24)21-16-7-8-20-18(23-16)22-13-4-2-3-12(9-13)17(19)25/h2-10,24H,1H3,(H2,19,25)(H2,20,21,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	7.4	22
GSK					Assay Description Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...				Bioorg Med Chem Lett 17: 4363-8 (2007) Article DOI: 10.1016/j.bmcl.2007.04.029 BindingDB Entry DOI: 10.7270/Q21R6NTD
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus)	BDBM26154 (2,4-dianilino pyrimidine, 11 | 3-({4-[(5-fluoro-2-...) Show SMILES Cc1ccc(F)cc1Nc1ccnc(Nc2cccc(c2)C(N)=O)n1 Show InChI InChI=1S/C18H16FN5O/c1-11-5-6-13(19)10-15(11)23-16-7-8-21-18(24-16)22-14-4-2-3-12(9-14)17(20)25/h2-10H,1H3,(H2,20,25)(H2,21,22,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	270	n/a	n/a	n/a	n/a	7.4	22
GSK					Assay Description Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...				Bioorg Med Chem Lett 17: 4363-8 (2007) Article DOI: 10.1016/j.bmcl.2007.04.029 BindingDB Entry DOI: 10.7270/Q21R6NTD
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus)	BDBM13224 (2-N-benzene-4-methyl-5-N-(2,4,6-trimethylphenyl)-1...) Show SMILES Cc1nc(NC(=O)c2ccccc2)sc1C(=O)Nc1c(C)cc(C)cc1C Show InChI InChI=1S/C21H21N3O2S/c1-12-10-13(2)17(14(3)11-12)23-20(26)18-15(4)22-21(27-18)24-19(25)16-8-6-5-7-9-16/h5-11H,1-4H3,(H,23,26)(H,22,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description In vitro inhibition of murine Lck kinase.				Bioorg Med Chem Lett 13: 4007-10 (2003) BindingDB Entry DOI: 10.7270/Q2CC103J
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus)	BDBM13224 (2-N-benzene-4-methyl-5-N-(2,4,6-trimethylphenyl)-1...) Show SMILES Cc1nc(NC(=O)c2ccccc2)sc1C(=O)Nc1c(C)cc(C)cc1C Show InChI InChI=1S/C21H21N3O2S/c1-12-10-13(2)17(14(3)11-12)23-20(26)18-15(4)22-21(27-18)24-19(25)16-8-6-5-7-9-16/h5-11H,1-4H3,(H,23,26)(H,22,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	320	n/a	n/a	n/a	n/a	7.0	22
Bristol-Myers Squibb Company					Assay Description IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...				J Med Chem 49: 6819-32 (2006) Article DOI: 10.1021/jm060727j BindingDB Entry DOI: 10.7270/Q2QN6501
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus)	BDBM26168 (2,4-dianilino pyrimidine, 25 | 3-({4-[(2,4-difluor...) Show SMILES NS(=O)(=O)c1cccc(Nc2nccc(Nc3ccc(F)cc3F)n2)c1 Show InChI InChI=1S/C16H13F2N5O2S/c17-10-4-5-14(13(18)8-10)22-15-6-7-20-16(23-15)21-11-2-1-3-12(9-11)26(19,24)25/h1-9H,(H2,19,24,25)(H2,20,21,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	7.4	22
GSK					Assay Description Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...				Bioorg Med Chem Lett 17: 4363-8 (2007) Article DOI: 10.1016/j.bmcl.2007.04.029 BindingDB Entry DOI: 10.7270/Q21R6NTD
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus)	BDBM26155 (2,4-dianilino pyrimidine, 12 | 3-({4-[(5-chloro-2-...) Show SMILES Cc1ccc(Cl)cc1Nc1ccnc(Nc2cccc(c2)C(N)=O)n1 Show InChI InChI=1S/C18H16ClN5O/c1-11-5-6-13(19)10-15(11)23-16-7-8-21-18(24-16)22-14-4-2-3-12(9-14)17(20)25/h2-10H,1H3,(H2,20,25)(H2,21,22,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	380	n/a	n/a	n/a	n/a	7.4	22
GSK					Assay Description Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...				Bioorg Med Chem Lett 17: 4363-8 (2007) Article DOI: 10.1016/j.bmcl.2007.04.029 BindingDB Entry DOI: 10.7270/Q21R6NTD
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus)	BDBM50298225 (CHEMBL2069955 | CHEMBL573578 | NM-PP1 | US10544104...) Show SMILES CC(C)(C)n1nc(Cc2cccc3ccccc23)c2c(N)ncnc12 Show InChI InChI=1S/C20H21N5/c1-20(2,3)25-19-17(18(21)22-12-23-19)16(24-25)11-14-9-6-8-13-7-4-5-10-15(13)14/h4-10,12H,11H2,1-3H3,(H2,21,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	460	n/a	n/a	n/a	n/a	n/a	n/a
University of Dundee Curated by ChEMBL					Assay Description Inhibition of Lck in the presence of 50uM ATP				Biochem J 408: 297-315 (2007) Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus)	BDBM26176 (2,4-dianilino pyrimidine, 33 | 3-{[4-(1H-1,2,3-ben...) Show SMILES NC(=O)c1cccc(Nc2nccc(Nc3cccc4nn[nH]c34)n2)c1 Show InChI InChI=1S/C17H14N8O/c18-16(26)10-3-1-4-11(9-10)20-17-19-8-7-14(22-17)21-12-5-2-6-13-15(12)24-25-23-13/h1-9H,(H2,18,26)(H,23,24,25)(H2,19,20,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	490	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...				Bioorg Med Chem Lett 17: 4363-8 (2007) Article DOI: 10.1016/j.bmcl.2007.04.029 BindingDB Entry DOI: 10.7270/Q21R6NTD
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus)	BDBM13223 (2-acetamido-4-methyl-N-(2,4,6-trimethylphenyl)-1,3...) Show SMILES CC(=O)Nc1nc(C)c(s1)C(=O)Nc1c(C)cc(C)cc1C Show InChI InChI=1S/C16H19N3O2S/c1-8-6-9(2)13(10(3)7-8)19-15(21)14-11(4)17-16(22-14)18-12(5)20/h6-7H,1-5H3,(H,19,21)(H,17,18,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	510	n/a	n/a	n/a	n/a	7.0	22
Bristol-Myers Squibb Company					Assay Description IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...				J Med Chem 49: 6819-32 (2006) Article DOI: 10.1021/jm060727j BindingDB Entry DOI: 10.7270/Q2QN6501
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus)	BDBM26181 (2,4-dianilino pyrimidine, 38 | 3-({4-[(6-methyl-1H...) Show SMILES Cc1cc(Nc2ccnc(Nc3cccc(c3)C(N)=O)n2)c2cn[nH]c2c1 Show InChI InChI=1S/C19H17N7O/c1-11-7-15(14-10-22-26-16(14)8-11)24-17-5-6-21-19(25-17)23-13-4-2-3-12(9-13)18(20)27/h2-10H,1H3,(H2,20,27)(H,22,26)(H2,21,23,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	520	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...				Bioorg Med Chem Lett 17: 4363-8 (2007) Article DOI: 10.1016/j.bmcl.2007.04.029 BindingDB Entry DOI: 10.7270/Q21R6NTD
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus)	BDBM26175 (2,4-dianilino pyrimidine, 32 | 3-{[4-(quinolin-5-y...) Show SMILES NC(=O)c1cccc(Nc2nccc(Nc3cccc4ncccc34)n2)c1 Show InChI InChI=1S/C20H16N6O/c21-19(27)13-4-1-5-14(12-13)24-20-23-11-9-18(26-20)25-17-8-2-7-16-15(17)6-3-10-22-16/h1-12H,(H2,21,27)(H2,23,24,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	560	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...				Bioorg Med Chem Lett 17: 4363-8 (2007) Article DOI: 10.1016/j.bmcl.2007.04.029 BindingDB Entry DOI: 10.7270/Q21R6NTD
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus)	BDBM50153835 (1-(3-dimethylaminophenylcarboxamido)-3-(4-hydroxyp...) Show SMILES CN(C)c1cccc(c1)C(=O)Nc1ccc(C)c(NC(=O)c2ccc(O)cc2)c1 Show InChI InChI=1S/C23H23N3O3/c1-15-7-10-18(24-23(29)17-5-4-6-19(13-17)26(2)3)14-21(15)25-22(28)16-8-11-20(27)12-9-16/h4-14,27H,1-3H3,(H,24,29)(H,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	570	n/a	n/a	n/a	n/a	n/a	n/a
University of Dundee Curated by ChEMBL					Assay Description Inhibition of Lck in the presence of 50uM ATP				Biochem J 408: 297-315 (2007) Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus)	BDBM50229961 (1-(1,1-dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazo...) Show SMILES CC(C)(C)n1nc(-c2cccc3ccccc23)c2c(N)ncnc12 Show InChI InChI=1S/C19H19N5/c1-19(2,3)24-18-15(17(20)21-11-22-18)16(23-24)14-10-6-8-12-7-4-5-9-13(12)14/h4-11H,1-3H3,(H2,20,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	660	n/a	n/a	n/a	n/a	n/a	n/a
University of Dundee Curated by ChEMBL					Assay Description Inhibition of Lck in the presence of 50uM ATP				Biochem J 408: 297-315 (2007) Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus)	BDBM13222 (2-[[(Methoxy)carbonyl]-amino]-4-methyl-N-(2,4,6-tr...) Show SMILES COC(=O)Nc1nc(C)c(s1)C(=O)Nc1c(C)cc(C)cc1C Show InChI InChI=1S/C16H19N3O3S/c1-8-6-9(2)12(10(3)7-8)18-14(20)13-11(4)17-15(23-13)19-16(21)22-5/h6-7H,1-5H3,(H,18,20)(H,17,19,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	720	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description In vitro inhibition of murine Lck kinase.				Bioorg Med Chem Lett 13: 4007-10 (2003) BindingDB Entry DOI: 10.7270/Q2CC103J
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus)	BDBM13222 (2-[[(Methoxy)carbonyl]-amino]-4-methyl-N-(2,4,6-tr...) Show SMILES COC(=O)Nc1nc(C)c(s1)C(=O)Nc1c(C)cc(C)cc1C Show InChI InChI=1S/C16H19N3O3S/c1-8-6-9(2)12(10(3)7-8)18-14(20)13-11(4)17-15(23-13)19-16(21)22-5/h6-7H,1-5H3,(H,18,20)(H,17,19,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	720	n/a	n/a	n/a	n/a	7.0	22
Bristol-Myers Squibb Company					Assay Description IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...				J Med Chem 49: 6819-32 (2006) Article DOI: 10.1021/jm060727j BindingDB Entry DOI: 10.7270/Q2QN6501
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus)	BDBM50248765 (1-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrol...) Show SMILES Cc1ccc(cc1)-c1c(C(=O)CF)n(CCCO)c2ncnc(N)c12 Show InChI InChI=1S/C18H19FN4O2/c1-11-3-5-12(6-4-11)14-15-17(20)21-10-22-18(15)23(7-2-8-24)16(14)13(25)9-19/h3-6,10,24H,2,7-9H2,1H3,(H2,20,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	750	n/a	n/a	n/a	n/a	n/a	n/a
University of Dundee Curated by ChEMBL					Assay Description Inhibition of Lck in the presence of 50uM ATP				Biochem J 408: 297-315 (2007) Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus)	BDBM26150 (2,4-dianilino pyrimidine, 7 | 3-[(4-{[5-hydroxy-2-...) Show SMILES CC(C)c1ccc(O)cc1Nc1ccnc(Nc2cccc(c2)C(N)=O)n1 Show InChI InChI=1S/C20H21N5O2/c1-12(2)16-7-6-15(26)11-17(16)24-18-8-9-22-20(25-18)23-14-5-3-4-13(10-14)19(21)27/h3-12,26H,1-2H3,(H2,21,27)(H2,22,23,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	880	n/a	n/a	n/a	n/a	7.4	22
GSK					Assay Description Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...				Bioorg Med Chem Lett 17: 4363-8 (2007) Article DOI: 10.1016/j.bmcl.2007.04.029 BindingDB Entry DOI: 10.7270/Q21R6NTD
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus)	BDBM26165 (2,4-dianilino pyrimidine, 22 | 3-({4-[(2,4-difluor...) Show SMILES NC(=O)c1cccc(Nc2nccc(Nc3ccc(F)cc3F)n2)c1 Show InChI InChI=1S/C17H13F2N5O/c18-11-4-5-14(13(19)9-11)23-15-6-7-21-17(24-15)22-12-3-1-2-10(8-12)16(20)25/h1-9H,(H2,20,25)(H2,21,22,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	7.4	22
GSK					Assay Description Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...				Bioorg Med Chem Lett 17: 4363-8 (2007) Article DOI: 10.1016/j.bmcl.2007.04.029 BindingDB Entry DOI: 10.7270/Q21R6NTD
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus)	BDBM26158 (2,4-dianilino pyrimidine, 15 | 3-({2-[(3-carbamoyl...) Show SMILES Cc1ccc(cc1Nc1ccnc(Nc2cccc(c2)C(N)=O)n1)C(N)=O Show InChI InChI=1S/C19H18N6O2/c1-11-5-6-13(18(21)27)10-15(11)24-16-7-8-22-19(25-16)23-14-4-2-3-12(9-14)17(20)26/h2-10H,1H3,(H2,20,26)(H2,21,27)(H2,22,23,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	7.4	22
GSK					Assay Description Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...				Bioorg Med Chem Lett 17: 4363-8 (2007) Article DOI: 10.1016/j.bmcl.2007.04.029 BindingDB Entry DOI: 10.7270/Q21R6NTD
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus)	BDBM26177 (2,4-dianilino pyrimidine, 34 | 3-{[4-(1H-indazol-7...) Show SMILES NC(=O)c1cccc(Nc2nccc(Nc3cccc4cn[nH]c34)n2)c1 Show InChI InChI=1S/C18H15N7O/c19-17(26)11-3-1-5-13(9-11)22-18-20-8-7-15(24-18)23-14-6-2-4-12-10-21-25-16(12)14/h1-10H,(H2,19,26)(H,21,25)(H2,20,22,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...				Bioorg Med Chem Lett 17: 4363-8 (2007) Article DOI: 10.1016/j.bmcl.2007.04.029 BindingDB Entry DOI: 10.7270/Q21R6NTD
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus)	BDBM26183 (2,4-dianilino pyrimidine, 40 | 3-({4-[(1-methyl-1H...) Show SMILES Cn1ncc2c(Nc3ccnc(Nc4cccc(c4)C(N)=O)n3)cccc12 Show InChI InChI=1S/C19H17N7O/c1-26-16-7-3-6-15(14(16)11-22-26)24-17-8-9-21-19(25-17)23-13-5-2-4-12(10-13)18(20)27/h2-11H,1H3,(H2,20,27)(H2,21,23,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...				Bioorg Med Chem Lett 17: 4363-8 (2007) Article DOI: 10.1016/j.bmcl.2007.04.029 BindingDB Entry DOI: 10.7270/Q21R6NTD
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus)	BDBM26164 (2,4-dianilino pyrimidine, 21 | 3-[(4-{[3-(N-methyl...) Show SMILES CN(C(C)=O)c1cccc(Nc2ccnc(Nc3cccc(c3)C(N)=O)n2)c1 Show InChI InChI=1S/C20H20N6O2/c1-13(27)26(2)17-8-4-7-16(12-17)23-18-9-10-22-20(25-18)24-15-6-3-5-14(11-15)19(21)28/h3-12H,1-2H3,(H2,21,28)(H2,22,23,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	7.4	22
GSK					Assay Description Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...				Bioorg Med Chem Lett 17: 4363-8 (2007) Article DOI: 10.1016/j.bmcl.2007.04.029 BindingDB Entry DOI: 10.7270/Q21R6NTD
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus)	BDBM26172 (2,4-dianilino pyrimidine, 29 | 3-({4-[(1-methyl-1H...) Show SMILES Cn1cnc2cc(Nc3ccnc(Nc4cccc(c4)C(N)=O)n3)ccc12 Show InChI InChI=1S/C19H17N7O/c1-26-11-22-15-10-14(5-6-16(15)26)23-17-7-8-21-19(25-17)24-13-4-2-3-12(9-13)18(20)27/h2-11H,1H3,(H2,20,27)(H2,21,23,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	7.4	22
GSK					Assay Description Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...				Bioorg Med Chem Lett 17: 4363-8 (2007) Article DOI: 10.1016/j.bmcl.2007.04.029 BindingDB Entry DOI: 10.7270/Q21R6NTD
					More data for this Ligand-Target Pair

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