Compile Data Set for Download or QSAR

Found 242 hits of ic50 for UniProtKB: P05412   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transcription factor Jun (Homo sapiens (Human))	BDBM50135483 (1-(6-Methoxy-2-thiophen-2-yl-quinazolin-4-ylamino)...) Show SMILES COc1ccc2nc(nc(NN3C(=O)C=C(C)C3=O)c2c1)-c1cccs1 |t:14| Show InChI InChI=1S/C18H14N4O3S/c1-10-8-15(23)22(18(10)24)21-16-12-9-11(25-2)5-6-13(12)19-17(20-16)14-4-3-7-26-14/h3-9H,1-2H3,(H,19,20,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Inhibition of AP-1-mediated transcriptional activation in human Jurkat cells by luciferase reporter gene assay				J Med Chem 57: 6930-48 (2014) Article DOI: 10.1021/jm5004733 BindingDB Entry DOI: 10.7270/Q2222WDT
					More data for this Ligand-Target Pair
Transcription factor Jun (Homo sapiens (Human))	BDBM50135482 (1-(5-Methoxy-2-thiophen-2-yl-quinazolin-4-ylamino)...) Show SMILES COc1cccc2nc(nc(NN3C(=O)C=C(C)C3=O)c12)-c1cccs1 |t:15| Show InChI InChI=1S/C18H14N4O3S/c1-10-9-14(23)22(18(10)24)21-17-15-11(5-3-6-12(15)25-2)19-16(20-17)13-7-4-8-26-13/h3-9H,1-2H3,(H,19,20,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Inhibition of AP-1-mediated transcriptional activation in human Jurkat cells by luciferase reporter gene assay				J Med Chem 57: 6930-48 (2014) Article DOI: 10.1021/jm5004733 BindingDB Entry DOI: 10.7270/Q2222WDT
					More data for this Ligand-Target Pair
Transcription factor Jun (Homo sapiens (Human))	BDBM50340608 (8-(6-methylpyridin-3-yl)-N-(4-(3-morpholino-1H-1,2...) Show SMILES Cc1ccc(cn1)-c1cccc2cnc(Nc3ccc(cc3)-n3cnc(n3)N3CCOCC3)nc12 Show InChI InChI=1S/C26H24N8O/c1-18-5-6-19(15-27-18)23-4-2-3-20-16-28-25(31-24(20)23)30-21-7-9-22(10-8-21)34-17-29-26(32-34)33-11-13-35-14-12-33/h2-10,15-17H,11-14H2,1H3,(H,28,30,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of c-Jun				Bioorg Med Chem Lett 21: 1719-23 (2011) Article DOI: 10.1016/j.bmcl.2011.01.079 BindingDB Entry DOI: 10.7270/Q2F1901V
					More data for this Ligand-Target Pair
Protein c-Fos/Transcription factor Jun (Homo sapiens (Human))	BDBM50090430 (4-(3-Methyl-2,5-dioxo-2,5-dihydro-pyrrol-1-ylamino...) Show SMILES CCOC(=O)c1cnc(nc1NN1C(=O)C=C(C)C1=O)-c1cccs1 |t:16| Show InChI InChI=1S/C16H14N4O4S/c1-3-24-16(23)10-8-17-14(11-5-4-6-25-11)18-13(10)19-20-12(21)7-9(2)15(20)22/h4-8H,3H2,1-2H3,(H,17,18,19)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Signal Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of AP-1 (activator protein-1) mediated transcriptional activation in Jurkat T-cells				Bioorg Med Chem Lett 10: 1645-8 (2000) BindingDB Entry DOI: 10.7270/Q2F190XH
					More data for this Ligand-Target Pair
Transcription factor Jun (Homo sapiens (Human))	BDBM50092879 (2-Chloro-4-methyl-pyrimidine-5-carboxylic acid (3,...) Show SMILES Cc1nc(Cl)ncc1C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C14H8ClF6N3O/c1-6-10(5-22-12(15)23-6)11(25)24-9-3-7(13(16,17)18)2-8(4-9)14(19,20)21/h2-5H,1H3,(H,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Inhibition of AP-1-mediated transcriptional activation in human Jurkat cells by luciferase reporter gene assay				J Med Chem 57: 6930-48 (2014) Article DOI: 10.1021/jm5004733 BindingDB Entry DOI: 10.7270/Q2222WDT
					More data for this Ligand-Target Pair
Transcription factor Jun (Homo sapiens (Human))	BDBM50090430 (4-(3-Methyl-2,5-dioxo-2,5-dihydro-pyrrol-1-ylamino...) Show SMILES CCOC(=O)c1cnc(nc1NN1C(=O)C=C(C)C1=O)-c1cccs1 |t:16| Show InChI InChI=1S/C16H14N4O4S/c1-3-24-16(23)10-8-17-14(11-5-4-6-25-11)18-13(10)19-20-12(21)7-9(2)15(20)22/h4-8H,3H2,1-2H3,(H,17,18,19)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Inhibition of AP-1-mediated transcriptional activation in human Jurkat cells by luciferase reporter gene assay				J Med Chem 57: 6930-48 (2014) Article DOI: 10.1021/jm5004733 BindingDB Entry DOI: 10.7270/Q2222WDT
					More data for this Ligand-Target Pair
Transcription factor Jun (Homo sapiens (Human))	BDBM50092879 (2-Chloro-4-methyl-pyrimidine-5-carboxylic acid (3,...) Show SMILES Cc1nc(Cl)ncc1C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C14H8ClF6N3O/c1-6-10(5-22-12(15)23-6)11(25)24-9-3-7(13(16,17)18)2-8(4-9)14(19,20)21/h2-5H,1H3,(H,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Signal Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Concentration required to inhibit activator protein-1(AP-1) mediated transcriptional activation in human Jurkat T-cells				J Med Chem 43: 3995-4004 (2000) BindingDB Entry DOI: 10.7270/Q26M363N
					More data for this Ligand-Target Pair
Transcription factor Jun (Homo sapiens (Human))	BDBM50295171 (AILANTHINONE | CHEMBL487194) Show SMILES CCC(C)C(=O)O[C@@H]1[C@H]2[C@@H](C)[C@@H](O)[C@@]3(O)OC[C@@]22[C@H]3[C@]3(C)[C@@H](C[C@H]2OC1=O)C(C)CC(=O)C3=O |r,TLB:12:11:18:16.15,10:9:18:16.15,7:8:18:16.15| Show InChI InChI=1S/C25H34O9/c1-6-10(2)20(29)34-17-16-12(4)18(27)25(31)22-23(5)13(11(3)7-14(26)19(23)28)8-15(33-21(17)30)24(16,22)9-32-25/h10-13,15-18,22,27,31H,6-9H2,1-5H3/t10?,11?,12-,13+,15-,16-,17-,18-,22-,23-,24+,25-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute Curated by ChEMBL					Assay Description Inhibition of TPA-induced AP1 transfected in HEK293 cells assessed as inhibition of beta-lactamase reporter activity treated 1 hr before TPA stimulat...				J Nat Prod 72: 503-6 (2010) Article DOI: 10.1021/np800732n BindingDB Entry DOI: 10.7270/Q2BZ66ZP
					More data for this Ligand-Target Pair
Transcription factor Jun (Homo sapiens (Human))	BDBM50044568 (CHEMBL85822) Show SMILES CCOC(=O)c1cnc(nc1CC)N(C)N1C(=O)C=C(C)C1=O |t:19| Show InChI InChI=1S/C15H18N4O4/c1-5-11-10(14(22)23-6-2)8-16-15(17-11)18(4)19-12(20)7-9(3)13(19)21/h7-8H,5-6H2,1-4H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Inhibition of AP-1-mediated transcriptional activation in human Jurkat cells by luciferase reporter gene assay				J Med Chem 57: 6930-48 (2014) Article DOI: 10.1021/jm5004733 BindingDB Entry DOI: 10.7270/Q2222WDT
					More data for this Ligand-Target Pair
Transcription factor Jun (Homo sapiens (Human))	BDBM50349194 (GLAUCARUBINONE | NSC-14975) Show SMILES CC[C@](C)(O)C(=O)O[C@@H]1[C@H]2[C@@H](C)[C@@H](O)[C@]3(O)OC[C@@]22[C@H]3[C@]3(C)[C@@H](C[C@H]2OC1=O)C(C)CC(=O)C3=O |r,TLB:11:10:19:17.16,8:9:19:17.16,13:12:19:17.16| Show InChI InChI=1S/C25H34O10/c1-6-22(4,31)21(30)35-16-15-11(3)17(27)25(32)20-23(5)12(10(2)7-13(26)18(23)28)8-14(34-19(16)29)24(15,20)9-33-25/h10-12,14-17,20,27,31-32H,6-9H2,1-5H3/t10?,11-,12+,14-,15-,16-,17-,20-,22+,23-,24+,25+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute Curated by ChEMBL					Assay Description Inhibition of TPA-induced AP1 transfected in HEK293 cells assessed as inhibition of beta-lactamase reporter activity treated 1 hr before TPA stimulat...				J Nat Prod 72: 503-6 (2010) Article DOI: 10.1021/np800732n BindingDB Entry DOI: 10.7270/Q2BZ66ZP
					More data for this Ligand-Target Pair
Transcription factor Jun (Homo sapiens (Human))	BDBM50340627 (7,8-bis(1-methyl-1H-pyrazol-4-yl)-N-(4-(3-morpholi...) Show SMILES Cn1cc(cn1)-c1ccc2cnc(Nc3ccc(cc3)-n3cnc(n3)N3CCOCC3)nc2c1-c1cnn(C)c1 Show InChI InChI=1S/C28H27N11O/c1-36-16-20(14-31-36)24-8-3-19-13-29-27(34-26(19)25(24)21-15-32-37(2)17-21)33-22-4-6-23(7-5-22)39-18-30-28(35-39)38-9-11-40-12-10-38/h3-8,13-18H,9-12H2,1-2H3,(H,29,33,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of c-Jun				Bioorg Med Chem Lett 21: 1719-23 (2011) Article DOI: 10.1016/j.bmcl.2011.01.079 BindingDB Entry DOI: 10.7270/Q2F1901V
					More data for this Ligand-Target Pair
Transcription factor Jun (Homo sapiens (Human))	BDBM50340606 (CHEMBL1761561 | N-(4-(3-(6-methylpyridin-3-yl)-1H-...) Show SMILES Cc1ccc(cn1)-c1ncn(n1)-c1ccc(Nc2ncc3ccc(cc3n2)-c2cn[nH]c2)cc1 Show InChI InChI=1S/C25H19N9/c1-16-2-3-19(12-26-16)24-28-15-34(33-24)22-8-6-21(7-9-22)31-25-27-11-18-5-4-17(10-23(18)32-25)20-13-29-30-14-20/h2-15H,1H3,(H,29,30)(H,27,31,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of c-Jun				Bioorg Med Chem Lett 21: 1719-23 (2011) Article DOI: 10.1016/j.bmcl.2011.01.079 BindingDB Entry DOI: 10.7270/Q2F1901V
					More data for this Ligand-Target Pair
Transcription factor Jun (Homo sapiens (Human))	BDBM50340628 (7-(1-methyl-1H-pyrazol-4-yl)-N-(4-(3-morpholino-1H...) Show SMILES Cn1cc(cn1)-c1ccc2cnc(Nc3ccc(cc3)-n3cnc(n3)N3CCOCC3)nc2c1-c1ccccc1 Show InChI InChI=1S/C30H27N9O/c1-37-19-23(18-33-37)26-12-7-22-17-31-29(35-28(22)27(26)21-5-3-2-4-6-21)34-24-8-10-25(11-9-24)39-20-32-30(36-39)38-13-15-40-16-14-38/h2-12,17-20H,13-16H2,1H3,(H,31,34,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of c-Jun				Bioorg Med Chem Lett 21: 1719-23 (2011) Article DOI: 10.1016/j.bmcl.2011.01.079 BindingDB Entry DOI: 10.7270/Q2F1901V
					More data for this Ligand-Target Pair
Transcription factor Jun (Homo sapiens (Human))	BDBM50044567 (CHEMBL86615) Show SMILES CCOC(=O)c1cnc(NN2C(=O)C=C(C)C2=O)nc1-c1ccc(C)s1 |t:13| Show InChI InChI=1S/C17H16N4O4S/c1-4-25-16(24)11-8-18-17(19-14(11)12-6-5-10(3)26-12)20-21-13(22)7-9(2)15(21)23/h5-8H,4H2,1-3H3,(H,18,19,20)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Inhibition of AP-1-mediated transcriptional activation in human Jurkat cells by luciferase reporter gene assay				J Med Chem 57: 6930-48 (2014) Article DOI: 10.1021/jm5004733 BindingDB Entry DOI: 10.7270/Q2222WDT
					More data for this Ligand-Target Pair
Transcription factor Jun (Homo sapiens (Human))	BDBM50062648 (2-Chloro-4-trifluoromethyl-pyrimidine-5-carboxylic...) Show SMILES FC(F)(F)c1cc(NC(=O)c2cnc(Cl)nc2C(F)(F)F)cc(c1)C(F)(F)F Show InChI InChI=1S/C14H5ClF9N3O/c15-11-25-4-8(9(27-11)14(22,23)24)10(28)26-7-2-5(12(16,17)18)1-6(3-7)13(19,20)21/h1-4H,(H,26,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Signal Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Concentration required to inhibit activator protein-1(AP-1) mediated transcriptional activation in human Jurkat T-cells				J Med Chem 43: 3995-4004 (2000) BindingDB Entry DOI: 10.7270/Q26M363N
					More data for this Ligand-Target Pair
Transcription factor Jun (Homo sapiens (Human))	BDBM50062648 (2-Chloro-4-trifluoromethyl-pyrimidine-5-carboxylic...) Show SMILES FC(F)(F)c1cc(NC(=O)c2cnc(Cl)nc2C(F)(F)F)cc(c1)C(F)(F)F Show InChI InChI=1S/C14H5ClF9N3O/c15-11-25-4-8(9(27-11)14(22,23)24)10(28)26-7-2-5(12(16,17)18)1-6(3-7)13(19,20)21/h1-4H,(H,26,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Inhibition of AP-1-mediated transcriptional activation in human Jurkat cells by luciferase reporter gene assay				J Med Chem 57: 6930-48 (2014) Article DOI: 10.1021/jm5004733 BindingDB Entry DOI: 10.7270/Q2222WDT
					More data for this Ligand-Target Pair
Transcription factor Jun (Homo sapiens (Human))	BDBM50340629 (8-methoxy-7-(1-methyl-1H-pyrazol-4-yl)-N-(4-(3-mor...) Show SMILES COc1c(ccc2cnc(Nc3ccc(cc3)-n3cnc(n3)N3CCOCC3)nc12)-c1cnn(C)c1 Show InChI InChI=1S/C25H25N9O2/c1-32-15-18(14-28-32)21-8-3-17-13-26-24(30-22(17)23(21)35-2)29-19-4-6-20(7-5-19)34-16-27-25(31-34)33-9-11-36-12-10-33/h3-8,13-16H,9-12H2,1-2H3,(H,26,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of c-Jun				Bioorg Med Chem Lett 21: 1719-23 (2011) Article DOI: 10.1016/j.bmcl.2011.01.079 BindingDB Entry DOI: 10.7270/Q2F1901V
					More data for this Ligand-Target Pair
Transcription factor Jun (Homo sapiens (Human))	BDBM50213931 (CHEMBL250854 | tylophorinidine) Show SMILES COc1ccc2c3[C@H](O)[C@@H]4CCCN4Cc3c3cc(OC)c(O)cc3c2c1 Show InChI InChI=1S/C22H23NO4/c1-26-12-5-6-13-14(8-12)15-9-19(24)20(27-2)10-16(15)17-11-23-7-3-4-18(23)22(25)21(13)17/h5-6,8-10,18,22,24-25H,3-4,7,11H2,1-2H3/t18-,22+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	n/a
Yale University Curated by ChEMBL					Assay Description Inhibition of AP1-mediated gene transcription in HepG2 cells by luciferase reporter gene assay				Bioorg Med Chem Lett 17: 4338-42 (2007) Article DOI: 10.1016/j.bmcl.2007.05.021 BindingDB Entry DOI: 10.7270/Q2HD7VBW
					More data for this Ligand-Target Pair
Transcription factor Jun (Homo sapiens (Human))	BDBM50213932 (CHEMBL250474 | [(R)-(+)-deoxytylophorinidine) Show SMILES COc1ccc2c3C[C@H]4CCCN4Cc3c3cc(OC)c(O)cc3c2c1 Show InChI InChI=1S/C22H23NO3/c1-25-14-5-6-15-16-8-13-4-3-7-23(13)12-20(16)19-11-22(26-2)21(24)10-18(19)17(15)9-14/h5-6,9-11,13,24H,3-4,7-8,12H2,1-2H3/t13-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	68	n/a	n/a	n/a	n/a	n/a	n/a
Yale University Curated by ChEMBL					Assay Description Inhibition of AP1-mediated gene transcription in HepG2 cells by luciferase reporter gene assay				Bioorg Med Chem Lett 17: 4338-42 (2007) Article DOI: 10.1016/j.bmcl.2007.05.021 BindingDB Entry DOI: 10.7270/Q2HD7VBW
					More data for this Ligand-Target Pair
Transcription factor Jun (Homo sapiens (Human))	BDBM50295170 (6R-senecionylchaparrin | CHEMBL564009) Show SMILES [#6]-[#6@H]-1-[#6@@H](-[#8])[C@@]2([#8])[#8]-[#6][C@]34[#6@H]2[C@@]2([#6])[#6@H](-[#8])-[#6@@H](-[#8])-[#6]=[#6](-[#6])-[#6@@H]2-[#6@@H](-[#8]-[#6](=O)\[#6]=[#6](\[#6])-[#6])-[#6@H]3-[#8]-[#6](=O)-[#6]-[#6@@H]-14 |r,t:17,TLB:3:2:9:6.7,0:1:9:6.7,32:33:9:6.7| Show InChI InChI=1S/C25H34O9/c1-10(2)6-15(27)33-18-17-11(3)7-14(26)20(30)23(17,5)22-24-9-32-25(22,31)19(29)12(4)13(24)8-16(28)34-21(18)24/h6-7,12-14,17-22,26,29-31H,8-9H2,1-5H3/t12-,13+,14+,17-,18-,19-,20-,21-,22-,23-,24-,25-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	71	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute Curated by ChEMBL					Assay Description Inhibition of TPA-induced AP1 transfected in HEK293 cells assessed as inhibition of beta-lactamase reporter activity treated 1 hr before TPA stimulat...				J Nat Prod 72: 503-6 (2010) Article DOI: 10.1021/np800732n BindingDB Entry DOI: 10.7270/Q2BZ66ZP
					More data for this Ligand-Target Pair
Transcription factor Jun (Homo sapiens (Human))	BDBM50044564 (CHEMBL315804) Show SMILES CC1=CC(=O)N(Nc2ncc(C(=O)c3ccccc3)c(n2)C(F)(F)F)C1=O |t:1| Show InChI InChI=1S/C17H11F3N4O3/c1-9-7-12(25)24(15(9)27)23-16-21-8-11(14(22-16)17(18,19)20)13(26)10-5-3-2-4-6-10/h2-8H,1H3,(H,21,22,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	98	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Inhibition of AP-1-mediated transcriptional activation in human Jurkat cells by luciferase reporter gene assay				J Med Chem 57: 6930-48 (2014) Article DOI: 10.1021/jm5004733 BindingDB Entry DOI: 10.7270/Q2222WDT
					More data for this Ligand-Target Pair
Transcription factor Jun (Homo sapiens (Human))	BDBM50340622 (8-chloro-7-(1-methyl-1H-pyrazol-4-yl)-N-(4-(3-morp...) Show SMILES Cn1cc(cn1)-c1ccc2cnc(Nc3ccc(cc3)-n3cnc(n3)N3CCOCC3)nc2c1Cl Show InChI InChI=1S/C24H22ClN9O/c1-32-14-17(13-28-32)20-7-2-16-12-26-23(30-22(16)21(20)25)29-18-3-5-19(6-4-18)34-15-27-24(31-34)33-8-10-35-11-9-33/h2-7,12-15H,8-11H2,1H3,(H,26,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of c-Jun				Bioorg Med Chem Lett 21: 1719-23 (2011) Article DOI: 10.1016/j.bmcl.2011.01.079 BindingDB Entry DOI: 10.7270/Q2F1901V
					More data for this Ligand-Target Pair
Transcription factor Jun (Homo sapiens (Human))	BDBM50092877 (2-Fluoro-4-trifluoromethyl-pyrimidine-5-carboxylic...) Show SMILES Fc1ncc(C(=O)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F)c(n1)C(F)(F)F Show InChI InChI=1S/C14H5F10N3O/c15-11-25-4-8(9(27-11)14(22,23)24)10(28)26-7-2-5(12(16,17)18)1-6(3-7)13(19,20)21/h1-4H,(H,26,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Inhibition of AP-1-mediated transcriptional activation in human Jurkat cells by luciferase reporter gene assay				J Med Chem 57: 6930-48 (2014) Article DOI: 10.1021/jm5004733 BindingDB Entry DOI: 10.7270/Q2222WDT
					More data for this Ligand-Target Pair
Transcription factor Jun (Homo sapiens (Human))	BDBM50044572 (CHEMBL3341912) Show SMILES FC(F)(F)c1ccc2Sc3nc(Cl)ncc3C(=O)Nc2c1 Show InChI InChI=1S/C12H5ClF3N3OS/c13-11-17-4-6-9(20)18-7-3-5(12(14,15)16)1-2-8(7)21-10(6)19-11/h1-4H,(H,18,20)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Inhibition of AP-1-mediated transcriptional activation in human Jurkat cells by luciferase reporter gene assay				J Med Chem 57: 6930-48 (2014) Article DOI: 10.1021/jm5004733 BindingDB Entry DOI: 10.7270/Q2222WDT
					More data for this Ligand-Target Pair
Transcription factor Jun (Homo sapiens (Human))	BDBM50090444 (4-(3-Methyl-2,5-dioxo-2,5-dihydro-pyrrol-1-ylamino...) Show SMILES CCOC(=O)c1cnc(nc1NN1C(=O)C=C(C)C1=O)-c1ccccc1 |t:16| Show InChI InChI=1S/C18H16N4O4/c1-3-26-18(25)13-10-19-15(12-7-5-4-6-8-12)20-16(13)21-22-14(23)9-11(2)17(22)24/h4-10H,3H2,1-2H3,(H,19,20,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Inhibition of AP-1-mediated transcriptional activation in human Jurkat cells by luciferase reporter gene assay				J Med Chem 57: 6930-48 (2014) Article DOI: 10.1021/jm5004733 BindingDB Entry DOI: 10.7270/Q2222WDT
					More data for this Ligand-Target Pair
Transcription factor Jun (Homo sapiens (Human))	BDBM50092877 (2-Fluoro-4-trifluoromethyl-pyrimidine-5-carboxylic...) Show SMILES Fc1ncc(C(=O)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F)c(n1)C(F)(F)F Show InChI InChI=1S/C14H5F10N3O/c15-11-25-4-8(9(27-11)14(22,23)24)10(28)26-7-2-5(12(16,17)18)1-6(3-7)13(19,20)21/h1-4H,(H,26,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Signal Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Concentration required to inhibit activator protein-1(AP-1) mediated transcriptional activation in human Jurkat T-cells				J Med Chem 43: 3995-4004 (2000) BindingDB Entry DOI: 10.7270/Q26M363N
					More data for this Ligand-Target Pair
Protein c-Fos/Transcription factor Jun (Homo sapiens (Human))	BDBM50090407 (4-(3-Methyl-2,5-dioxo-2,5-dihydro-pyrrol-1-ylamino...) Show SMILES CCOC(=O)c1cnc(nc1NN1C(=O)C=C(C)C1=O)-c1ccsc1 |t:16| Show InChI InChI=1S/C16H14N4O4S/c1-3-24-16(23)11-7-17-13(10-4-5-25-8-10)18-14(11)19-20-12(21)6-9(2)15(20)22/h4-8H,3H2,1-2H3,(H,17,18,19)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Signal Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of AP-1 (activator protein-1) mediated transcriptional activation in Jurkat T-cells				Bioorg Med Chem Lett 10: 1645-8 (2000) BindingDB Entry DOI: 10.7270/Q2F190XH
					More data for this Ligand-Target Pair
Protein c-Fos/Transcription factor Jun (Homo sapiens (Human))	BDBM50090444 (4-(3-Methyl-2,5-dioxo-2,5-dihydro-pyrrol-1-ylamino...) Show SMILES CCOC(=O)c1cnc(nc1NN1C(=O)C=C(C)C1=O)-c1ccccc1 |t:16| Show InChI InChI=1S/C18H16N4O4/c1-3-26-18(25)13-10-19-15(12-7-5-4-6-8-12)20-16(13)21-22-14(23)9-11(2)17(22)24/h4-10H,3H2,1-2H3,(H,19,20,21)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Signal Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of AP-1 (activator protein-1) mediated transcriptional activation in Jurkat T-cells				Bioorg Med Chem Lett 10: 1645-8 (2000) BindingDB Entry DOI: 10.7270/Q2F190XH
					More data for this Ligand-Target Pair
Transcription factor Jun (Homo sapiens (Human))	BDBM50213934 (CHEMBL398325 | tylophorinine) Show SMILES COc1ccc2c3[C@@H](O)[C@@H]4CCCN4Cc3c3cc(OC)c(OC)cc3c2c1 Show InChI InChI=1S/C23H25NO4/c1-26-13-6-7-14-15(9-13)16-10-20(27-2)21(28-3)11-17(16)18-12-24-8-4-5-19(24)23(25)22(14)18/h6-7,9-11,19,23,25H,4-5,8,12H2,1-3H3/t19-,23-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
Yale University Curated by ChEMBL					Assay Description Inhibition of AP1-mediated gene transcription in HepG2 cells by luciferase reporter gene assay				Bioorg Med Chem Lett 17: 4338-42 (2007) Article DOI: 10.1016/j.bmcl.2007.05.021 BindingDB Entry DOI: 10.7270/Q2HD7VBW
					More data for this Ligand-Target Pair
Transcription factor Jun (Homo sapiens (Human))	BDBM50340600 (CHEMBL1761555 | N-(4-(3-morpholino-1H-1,2,4-triazo...) Show SMILES C1CN(CCO1)c1ncn(n1)-c1ccc(Nc2ncc3ccc(cc3n2)-c2cn[nH]c2)cc1 Show InChI InChI=1S/C23H21N9O/c1-2-17-12-24-22(29-21(17)11-16(1)18-13-26-27-14-18)28-19-3-5-20(6-4-19)32-15-25-23(30-32)31-7-9-33-10-8-31/h1-6,11-15H,7-10H2,(H,26,27)(H,24,28,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of c-Jun				Bioorg Med Chem Lett 21: 1719-23 (2011) Article DOI: 10.1016/j.bmcl.2011.01.079 BindingDB Entry DOI: 10.7270/Q2F1901V
					More data for this Ligand-Target Pair
Transcription factor Jun (Homo sapiens (Human))	BDBM50340626 (8-cyclopropyl-7-(1-methyl-1H-pyrazol-4-yl)-N-(4-(3...) Show SMILES Cn1cc(cn1)-c1ccc2cnc(Nc3ccc(cc3)-n3cnc(n3)N3CCOCC3)nc2c1C1CC1 Show InChI InChI=1S/C27H27N9O/c1-34-16-20(15-30-34)23-9-4-19-14-28-26(32-25(19)24(23)18-2-3-18)31-21-5-7-22(8-6-21)36-17-29-27(33-36)35-10-12-37-13-11-35/h4-9,14-18H,2-3,10-13H2,1H3,(H,28,31,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of c-Jun				Bioorg Med Chem Lett 21: 1719-23 (2011) Article DOI: 10.1016/j.bmcl.2011.01.079 BindingDB Entry DOI: 10.7270/Q2F1901V
					More data for this Ligand-Target Pair
Transcription factor Jun (Homo sapiens (Human))	BDBM50340624 (8-methyl-7-(1-methyl-1H-pyrazol-4-yl)-N-(4-(3-morp...) Show SMILES Cc1c(ccc2cnc(Nc3ccc(cc3)-n3cnc(n3)N3CCOCC3)nc12)-c1cnn(C)c1 Show InChI InChI=1S/C25H25N9O/c1-17-22(19-14-28-32(2)15-19)8-3-18-13-26-24(30-23(17)18)29-20-4-6-21(7-5-20)34-16-27-25(31-34)33-9-11-35-12-10-33/h3-8,13-16H,9-12H2,1-2H3,(H,26,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of c-Jun				Bioorg Med Chem Lett 21: 1719-23 (2011) Article DOI: 10.1016/j.bmcl.2011.01.079 BindingDB Entry DOI: 10.7270/Q2F1901V
					More data for this Ligand-Target Pair
Protein c-Fos/Transcription factor Jun (Homo sapiens (Human))	BDBM50090431 (3-Methyl-1-[5-(4-methyl-oxazol-2-yl)-2-thiophen-2-...) Show SMILES CC1=CC(=O)N(Nc2nc(ncc2-c2nc(C)co2)-c2cccs2)C1=O |t:1| Show InChI InChI=1S/C17H13N5O3S/c1-9-6-13(23)22(17(9)24)21-14-11(16-19-10(2)8-25-16)7-18-15(20-14)12-4-3-5-26-12/h3-8H,1-2H3,(H,18,20,21)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Signal Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of AP-1 (activator protein-1) mediated transcriptional activation in Jurkat T-cells				Bioorg Med Chem Lett 10: 1645-8 (2000) BindingDB Entry DOI: 10.7270/Q2F190XH
					More data for this Ligand-Target Pair
Transcription factor Jun (Homo sapiens (Human))	BDBM50092882 (2,4-Dichloro-pyrimidine-5-carboxylic acid (3,5-bis...) Show SMILES FC(F)(F)c1cc(NC(=O)c2cnc(Cl)nc2Cl)cc(c1)C(F)(F)F Show InChI InChI=1S/C13H5Cl2F6N3O/c14-9-8(4-22-11(15)24-9)10(25)23-7-2-5(12(16,17)18)1-6(3-7)13(19,20)21/h1-4H,(H,23,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Signal Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Concentration required to inhibit activator protein-1(AP-1) mediated transcriptional activation in human Jurkat T-cells				J Med Chem 43: 3995-4004 (2000) BindingDB Entry DOI: 10.7270/Q26M363N
					More data for this Ligand-Target Pair
Protein c-Fos/Transcription factor Jun (Homo sapiens (Human))	BDBM50090443 (4-(3-Methyl-2,5-dioxo-2,5-dihydro-pyrrol-1-ylamino...) Show SMILES CCOC(=O)c1cnc(SC)nc1NN1C(=O)C=C(C)C1=O |t:18| Show InChI InChI=1S/C13H14N4O4S/c1-4-21-12(20)8-6-14-13(22-3)15-10(8)16-17-9(18)5-7(2)11(17)19/h5-6H,4H2,1-3H3,(H,14,15,16)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Signal Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of AP-1 (activator protein-1) mediated transcriptional activation in Jurkat T-cells				Bioorg Med Chem Lett 10: 1645-8 (2000) BindingDB Entry DOI: 10.7270/Q2F190XH
					More data for this Ligand-Target Pair
Transcription factor Jun (Homo sapiens (Human))	BDBM50340614 (CHEMBL1761569 | N-(4-(3-methyl-1H-1,2,4-triazol-1-...) Show SMILES Cc1ncn(n1)-c1ccc(Nc2ncc3cccc(-c4nccs4)c3n2)cc1 Show InChI InChI=1S/C20H15N7S/c1-13-23-12-27(26-13)16-7-5-15(6-8-16)24-20-22-11-14-3-2-4-17(18(14)25-20)19-21-9-10-28-19/h2-12H,1H3,(H,22,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of c-Jun				Bioorg Med Chem Lett 21: 1719-23 (2011) Article DOI: 10.1016/j.bmcl.2011.01.079 BindingDB Entry DOI: 10.7270/Q2F1901V
					More data for this Ligand-Target Pair
Protein c-Fos/Transcription factor Jun (Homo sapiens (Human))	BDBM50090406 (1-(5-(4,5-dihydrooxazol-2-yl)-2-(thiophen-2-yl)pyr...) Show SMILES CC1=CC(=O)N(Nc2nc(ncc2C2=NCCO2)-c2cccs2)C1=O |t:1,14| Show InChI InChI=1S/C16H13N5O3S/c1-9-7-12(22)21(16(9)23)20-13-10(15-17-4-5-24-15)8-18-14(19-13)11-3-2-6-25-11/h2-3,6-8H,4-5H2,1H3,(H,18,19,20)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Signal Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of AP-1 (activator protein-1) mediated transcriptional activation in Jurkat T-cells				Bioorg Med Chem Lett 10: 1645-8 (2000) BindingDB Entry DOI: 10.7270/Q2F190XH
					More data for this Ligand-Target Pair
Protein c-Fos/Transcription factor Jun (Homo sapiens (Human))	BDBM50090442 (3-Methyl-1-[5-(2-methyl-2H-tetrazol-5-yl)-2-thioph...) Show SMILES CC1=CC(=O)N(Nc2nc(ncc2-c2nnn(C)n2)-c2cccs2)C1=O |t:1| Show InChI InChI=1S/C15H12N8O2S/c1-8-6-11(24)23(15(8)25)20-12-9(13-18-21-22(2)19-13)7-16-14(17-12)10-4-3-5-26-10/h3-7H,1-2H3,(H,16,17,20)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Signal Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of AP-1 (activator protein-1) mediated transcriptional activation in Jurkat T-cells				Bioorg Med Chem Lett 10: 1645-8 (2000) BindingDB Entry DOI: 10.7270/Q2F190XH
					More data for this Ligand-Target Pair
Transcription factor Jun (Homo sapiens (Human))	BDBM50092882 (2,4-Dichloro-pyrimidine-5-carboxylic acid (3,5-bis...) Show SMILES FC(F)(F)c1cc(NC(=O)c2cnc(Cl)nc2Cl)cc(c1)C(F)(F)F Show InChI InChI=1S/C13H5Cl2F6N3O/c14-9-8(4-22-11(15)24-9)10(25)23-7-2-5(12(16,17)18)1-6(3-7)13(19,20)21/h1-4H,(H,23,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Inhibition of AP-1-mediated transcriptional activation in human Jurkat cells by luciferase reporter gene assay				J Med Chem 57: 6930-48 (2014) Article DOI: 10.1021/jm5004733 BindingDB Entry DOI: 10.7270/Q2222WDT
					More data for this Ligand-Target Pair
Protein c-Fos/Transcription factor Jun (Homo sapiens (Human))	BDBM50090420 (4-(3-Methyl-2,5-dioxo-2,5-dihydro-pyrrol-1-ylamino...) Show SMILES CCOC(=O)c1cnc(nc1NN1C(=O)C=C(C)C1=O)-c1ccc(C)s1 |t:16| Show InChI InChI=1S/C17H16N4O4S/c1-4-25-17(24)11-8-18-15(12-6-5-10(3)26-12)19-14(11)20-21-13(22)7-9(2)16(21)23/h5-8H,4H2,1-3H3,(H,18,19,20)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Signal Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of AP-1 (activator protein-1) mediated transcriptional activation in Jurkat T-cells				Bioorg Med Chem Lett 10: 1645-8 (2000) BindingDB Entry DOI: 10.7270/Q2F190XH
					More data for this Ligand-Target Pair
Transcription factor Jun (Homo sapiens (Human))	BDBM50044566 (CHEMBL87274) Show SMILES CC1=CC(=O)N(Nc2ncc(C(=O)OC(C)(C)C)c(n2)C(F)(F)F)C1=O |t:1| Show InChI InChI=1S/C15H15F3N4O4/c1-7-5-9(23)22(11(7)24)21-13-19-6-8(10(20-13)15(16,17)18)12(25)26-14(2,3)4/h5-6H,1-4H3,(H,19,20,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Inhibition of AP-1-mediated transcriptional activation in human Jurkat cells by luciferase reporter gene assay				J Med Chem 57: 6930-48 (2014) Article DOI: 10.1021/jm5004733 BindingDB Entry DOI: 10.7270/Q2222WDT
					More data for this Ligand-Target Pair
Transcription factor Jun (Homo sapiens (Human))	BDBM50340610 (8-(3-fluoro-4-methoxyphenyl)-N-(4-(3-morpholino-1H...) Show SMILES COc1ccc(cc1F)-c1cccc2cnc(Nc3ccc(cc3)-n3cnc(n3)N3CCOCC3)nc12 Show InChI InChI=1S/C27H24FN7O2/c1-36-24-10-5-18(15-23(24)28)22-4-2-3-19-16-29-26(32-25(19)22)31-20-6-8-21(9-7-20)35-17-30-27(33-35)34-11-13-37-14-12-34/h2-10,15-17H,11-14H2,1H3,(H,29,31,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of c-Jun				Bioorg Med Chem Lett 21: 1719-23 (2011) Article DOI: 10.1016/j.bmcl.2011.01.079 BindingDB Entry DOI: 10.7270/Q2F1901V
					More data for this Ligand-Target Pair
Transcription factor Jun (Homo sapiens (Human))	BDBM50340607 (7-(1-methyl-1H-pyrazol-4-yl)-N-(4-(3-(pyridin-2-yl...) Show SMILES Cn1cc(cn1)-c1ccc2cnc(Nc3ccc(cc3)-n3cnc(n3)-c3ccccn3)nc2c1 Show InChI InChI=1S/C25H19N9/c1-33-15-19(14-29-33)17-5-6-18-13-27-25(31-23(18)12-17)30-20-7-9-21(10-8-20)34-16-28-24(32-34)22-4-2-3-11-26-22/h2-16H,1H3,(H,27,30,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of c-Jun				Bioorg Med Chem Lett 21: 1719-23 (2011) Article DOI: 10.1016/j.bmcl.2011.01.079 BindingDB Entry DOI: 10.7270/Q2F1901V
					More data for this Ligand-Target Pair
Protein c-Fos/Transcription factor Jun (Homo sapiens (Human))	BDBM50090435 (3-Methyl-1-[5-(3-methyl-isoxazol-5-yl)-2-thiophen-...) Show SMILES CC1=CC(=O)N(Nc2nc(ncc2-c2cc(C)no2)-c2cccs2)C1=O |t:1| Show InChI InChI=1S/C17H13N5O3S/c1-9-6-14(23)22(17(9)24)20-15-11(12-7-10(2)21-25-12)8-18-16(19-15)13-4-3-5-26-13/h3-8H,1-2H3,(H,18,19,20)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Signal Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of AP-1 (activator protein-1) mediated transcriptional activation in Jurkat T-cells				Bioorg Med Chem Lett 10: 1645-8 (2000) BindingDB Entry DOI: 10.7270/Q2F190XH
					More data for this Ligand-Target Pair
Protein c-Fos/Transcription factor Jun (Homo sapiens (Human))	BDBM50090450 (3-Methyl-1-[5-(5-methyl-[1,3,4]oxadiazol-2-yl)-2-t...) Show SMILES CC1=CC(=O)N(Nc2nc(ncc2-c2nnc(C)o2)-c2cccs2)C1=O |t:1| Show InChI InChI=1S/C16H12N6O3S/c1-8-6-12(23)22(16(8)24)21-13-10(15-20-19-9(2)25-15)7-17-14(18-13)11-4-3-5-26-11/h3-7H,1-2H3,(H,17,18,21)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Signal Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of AP-1 (activator protein-1) mediated transcriptional activation in Jurkat T-cells				Bioorg Med Chem Lett 10: 1645-8 (2000) BindingDB Entry DOI: 10.7270/Q2F190XH
					More data for this Ligand-Target Pair
Transcription factor Jun (Homo sapiens (Human))	BDBM50213935 ((12aS,13R)-2,3,6,7-tetramethoxy-9,10,11,12,12a,13-...) Show SMILES COc1cc2c3CN4CCC[C@H]4[C@H](O)c3c3cc(OC)c(OC)cc3c2cc1OC Show InChI InChI=1S/C24H27NO5/c1-27-19-8-13-14-9-20(28-2)22(30-4)11-16(14)23-17(15(13)10-21(19)29-3)12-25-7-5-6-18(25)24(23)26/h8-11,18,24,26H,5-7,12H2,1-4H3/t18-,24-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>300	n/a	n/a	n/a	n/a	n/a	n/a
Yale University Curated by ChEMBL					Assay Description Inhibition of AP1-mediated gene transcription in HepG2 cells by luciferase reporter gene assay				Bioorg Med Chem Lett 17: 4338-42 (2007) Article DOI: 10.1016/j.bmcl.2007.05.021 BindingDB Entry DOI: 10.7270/Q2HD7VBW
					More data for this Ligand-Target Pair
Protein c-Fos/Transcription factor Jun (Homo sapiens (Human))	BDBM50090449 (2-(4-Chloro-phenyl)-4-(3-methyl-2,5-dioxo-2,5-dihy...) Show SMILES CCOC(=O)c1cnc(nc1NN1C(=O)C=C(C)C1=O)-c1ccc(Cl)cc1 |t:16| Show InChI InChI=1S/C18H15ClN4O4/c1-3-27-18(26)13-9-20-15(11-4-6-12(19)7-5-11)21-16(13)22-23-14(24)8-10(2)17(23)25/h4-9H,3H2,1-2H3,(H,20,21,22)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Signal Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of AP-1 (activator protein-1) mediated transcriptional activation in Jurkat T-cells				Bioorg Med Chem Lett 10: 1645-8 (2000) BindingDB Entry DOI: 10.7270/Q2F190XH
					More data for this Ligand-Target Pair
Protein c-Fos/Transcription factor Jun (Homo sapiens (Human))	BDBM50090429 (2-(3,5-Dichloro-phenyl)-4-(3-methyl-2,5-dioxo-2,5-...) Show SMILES CCOC(=O)c1cnc(nc1NN1C(=O)C=C(C)C1=O)-c1cc(Cl)cc(Cl)c1 |t:16| Show InChI InChI=1S/C18H14Cl2N4O4/c1-3-28-18(27)13-8-21-15(10-5-11(19)7-12(20)6-10)22-16(13)23-24-14(25)4-9(2)17(24)26/h4-8H,3H2,1-2H3,(H,21,22,23)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Signal Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of AP-1 (activator protein-1) mediated transcriptional activation in Jurkat T-cells				Bioorg Med Chem Lett 10: 1645-8 (2000) BindingDB Entry DOI: 10.7270/Q2F190XH
					More data for this Ligand-Target Pair
Transcription factor Jun (Homo sapiens (Human))	BDBM50213936 ((S)-2,3,6,7-tetramethoxy-8b,9,10,11,12,12a-hexahyd...) Show SMILES COc1cc2C3CN4CCC[C@H]4C=C3c3cc(OC)c(OC)cc3-c2cc1OC |w:5.5,c:13| Show InChI InChI=1S/C24H27NO4/c1-26-21-9-16-15-8-14-6-5-7-25(14)13-20(15)19-12-24(29-4)23(28-3)11-18(19)17(16)10-22(21)27-2/h8-12,14,20H,5-7,13H2,1-4H3/t14-,20?/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>300	n/a	n/a	n/a	n/a	n/a	n/a
Yale University Curated by ChEMBL					Assay Description Inhibition of AP1-mediated gene transcription in HepG2 cells by luciferase reporter gene assay				Bioorg Med Chem Lett 17: 4338-42 (2007) Article DOI: 10.1016/j.bmcl.2007.05.021 BindingDB Entry DOI: 10.7270/Q2HD7VBW
					More data for this Ligand-Target Pair
Protein c-Fos/Transcription factor Jun (Homo sapiens (Human))	BDBM50090433 (2-(5-Chloro-thiophen-2-yl)-4-(3-methyl-2,5-dioxo-2...) Show SMILES CCOC(=O)c1cnc(nc1NN1C(=O)C=C(C)C1=O)-c1ccc(Cl)s1 |t:16| Show InChI InChI=1S/C16H13ClN4O4S/c1-3-25-16(24)9-7-18-14(10-4-5-11(17)26-10)19-13(9)20-21-12(22)6-8(2)15(21)23/h4-7H,3H2,1-2H3,(H,18,19,20)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Signal Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of AP-1 (activator protein-1) mediated transcriptional activation in Jurkat T-cells				Bioorg Med Chem Lett 10: 1645-8 (2000) BindingDB Entry DOI: 10.7270/Q2F190XH
					More data for this Ligand-Target Pair

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