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Compile Data Set for Download or QSAR

Found 114 hits Enz. Inhib. hit(s) with all data for entry = 1164   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311486
PNG
(CHEM-US-00192 | US10155764, Example 65B)
Show SMILES C[C@@H](Nc1nn(C)c(=O)c2cccnc12)[C@H](N(C)C)c1ccccc1 |r|
Show InChI InChI=1S/C19H23N5O/c1-13(17(23(2)3)14-9-6-5-7-10-14)21-18-16-15(11-8-12-20-16)19(25)24(4)22-18/h5-13,17H,1-4H3,(H,21,22)/t13-,17+/m1/s1
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n/an/a 19n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311498
PNG
(CHEM-US-00210 | US10155764, Example 74A)
Show SMILES C[C@H](Nc1nn(C)c(=O)c2cccnc12)[C@@H](N(C)C)c1ccc(cc1)S(=O)(=O)c1ccccc1 |r|
Show InChI InChI=1S/C25H27N5O3S/c1-17(27-24-22-21(11-8-16-26-22)25(31)30(4)28-24)23(29(2)3)18-12-14-20(15-13-18)34(32,33)19-9-6-5-7-10-19/h5-17,23H,1-4H3,(H,27,28)/t17-,23+/m0/s1
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n/an/a 20n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311480
PNG
(CHEM-US-00186 | US10155764, Example 60)
Show SMILES C[C@H](Nc1nn(C)c(=O)c2ccccc12)[C@@H](N(C)C)c1ccccn1 |r|
Show InChI InChI=1S/C19H23N5O/c1-13(17(23(2)3)16-11-7-8-12-20-16)21-18-14-9-5-6-10-15(14)19(25)24(4)22-18/h5-13,17H,1-4H3,(H,21,22)/t13-,17+/m0/s1
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n/an/a 21n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311495
PNG
(CHEM-US-00207 | US10155764, Example 73A)
Show SMILES C[C@H](Nc1nn(C)c(=O)c2ccccc12)[C@@H](N(C)C)c1ccccc1 |r|
Show InChI InChI=1S/C20H24N4O/c1-14(18(23(2)3)15-10-6-5-7-11-15)21-19-16-12-8-9-13-17(16)20(25)24(4)22-19/h5-14,18H,1-4H3,(H,21,22)/t14-,18+/m0/s1
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n/an/a 23n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311483
PNG
(CHEM-US-00189 | US10155764, Example 63)
Show SMILES C[C@H](Nc1nn(C)c(=O)c2ccccc12)[C@@H](N(C)C)c1ccc(Oc2ccccc2)cc1 |r|
Show InChI InChI=1S/C26H28N4O2/c1-18(27-25-22-12-8-9-13-23(22)26(31)30(4)28-25)24(29(2)3)19-14-16-21(17-15-19)32-20-10-6-5-7-11-20/h5-18,24H,1-4H3,(H,27,28)/t18-,24+/m0/s1
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n/an/a 25n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311512
PNG
(CHEM-US-00232 | US10155764, Example 87)
Show SMILES C[C@H](Nc1nn(C)c(=O)c2cccnc12)[C@@H](N(C)C)c1ccc(cc1)C(=O)OCc1ccccc1 |r|
Show InChI InChI=1S/C27H29N5O3/c1-18(29-25-23-22(11-8-16-28-23)26(33)32(4)30-25)24(31(2)3)20-12-14-21(15-13-20)27(34)35-17-19-9-6-5-7-10-19/h5-16,18,24H,17H2,1-4H3,(H,29,30)/t18-,24+/m0/s1
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n/an/a 29n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311511
PNG
(US10155764, Example 86)
Show SMILES CC(C)OC(=O)c1ccc(cc1)[C@@H]([C@H](C)Nc1nn(C)c(=O)c2cccnc12)N(C)C |r|
Show InChI InChI=1S/C23H29N5O3/c1-14(2)31-23(30)17-11-9-16(10-12-17)20(27(4)5)15(3)25-21-19-18(8-7-13-24-19)22(29)28(6)26-21/h7-15,20H,1-6H3,(H,25,26)/t15-,20+/m0/s1
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n/an/a 30n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311479
PNG
(CHEM-US-00185 | US10155764, Example 59)
Show SMILES CC(C)Oc1ccc(cc1)[C@@H]([C@H](C)Nc1nn(C)c(=O)c2ccccc12)N(C)C |r|
Show InChI InChI=1S/C23H30N4O2/c1-15(2)29-18-13-11-17(12-14-18)21(26(4)5)16(3)24-22-19-9-7-8-10-20(19)23(28)27(6)25-22/h7-16,21H,1-6H3,(H,24,25)/t16-,21+/m0/s1
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n/an/a 33n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311490
PNG
(CHEM-US-00202 | US10155764, Example 70A)
Show SMILES C[C@H](Nc1nn(C)c(=O)c2cccc(C)c12)[C@@H](N(C)C)c1ccccc1 |r|
Show InChI InChI=1S/C21H26N4O/c1-14-10-9-13-17-18(14)20(23-25(5)21(17)26)22-15(2)19(24(3)4)16-11-7-6-8-12-16/h6-13,15,19H,1-5H3,(H,22,23)/t15-,19+/m0/s1
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n/an/a 36n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311502
PNG
(US10155764, Example 77)
Show SMILES C[C@H](Nc1nn(C)c(=O)c2ccccc12)[C@@H](N(C)C)c1ccc(OCc2ccccc2)cc1 |r|
Show InChI InChI=1S/C27H30N4O2/c1-19(28-26-23-12-8-9-13-24(23)27(32)31(4)29-26)25(30(2)3)21-14-16-22(17-15-21)33-18-20-10-6-5-7-11-20/h5-17,19,25H,18H2,1-4H3,(H,28,29)/t19-,25+/m0/s1
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n/an/a 36n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311448
PNG
(CHEM-US-00145 | US10155764, Example 34)
Show SMILES CN(C)[C@H]1CN(CC[C@@H]1Nc1nn(C)c(=O)c2ccccc12)c1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C22H26ClN5O/c1-26(2)20-14-28(16-10-8-15(23)9-11-16)13-12-19(20)24-21-17-6-4-5-7-18(17)22(29)27(3)25-21/h4-11,19-20H,12-14H2,1-3H3,(H,24,25)/t19-,20-/m0/s1
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n/an/a 40n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311497
PNG
(CHEM-US-00209 | US10155764, Example 74)
Show SMILES CC(Nc1nn(C)c(=O)c2cccnc12)C(N(C)C)c1ccc(cc1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C25H27N5O3S/c1-17(27-24-22-21(11-8-16-26-22)25(31)30(4)28-24)23(29(2)3)18-12-14-20(15-13-18)34(32,33)19-9-6-5-7-10-19/h5-17,23H,1-4H3,(H,27,28)
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n/an/a 40n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311478
PNG
(CHEM-US-00184 | US10155764, Example 58)
Show SMILES CC[C@H](Nc1nn(C)c(=O)c2cccnc12)[C@@H](N(C)C)c1ccccc1 |r|
Show InChI InChI=1S/C20H25N5O/c1-5-16(18(24(2)3)14-10-7-6-8-11-14)22-19-17-15(12-9-13-21-17)20(26)25(4)23-19/h6-13,16,18H,5H2,1-4H3,(H,22,23)/t16-,18-/m0/s1
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GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311476
PNG
(CHEM-US-00182 | US10155764, Example 56)
Show SMILES CC[C@H](Nc1nn(C)c(=O)c2ccccc12)[C@@H](N(C)C)c1ccccc1 |r|
Show InChI InChI=1S/C21H26N4O/c1-5-18(19(24(2)3)15-11-7-6-8-12-15)22-20-16-13-9-10-14-17(16)21(26)25(4)23-20/h6-14,18-19H,5H2,1-4H3,(H,22,23)/t18-,19-/m0/s1
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n/an/a 41n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311501
PNG
(US10155764, Example 76)
Show SMILES C[C@H](Nc1nn(C)c(=O)c2ccccc12)[C@@H](N(C)C)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C20H24N4O2/c1-13(18(23(2)3)14-9-11-15(25)12-10-14)21-19-16-7-5-6-8-17(16)20(26)24(4)22-19/h5-13,18,25H,1-4H3,(H,21,22)/t13-,18+/m0/s1
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GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311412
PNG
(US10155764, Example 8A)
Show SMILES C[C@@H](CN(C)C)Nc1nn(C)c(=O)c2cccnc12 |r|
Show InChI InChI=1S/C13H19N5O/c1-9(8-17(2)3)15-12-11-10(6-5-7-14-11)13(19)18(4)16-12/h5-7,9H,8H2,1-4H3,(H,15,16)/t9-/m0/s1
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GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311503
PNG
(CHEM-US-00222 | US10155764, Example 78)
Show SMILES C[C@H](Nc1nn(C)c(=O)c2ccccc12)[C@@H](N(C)C)c1ccc(OCC2CC2)cc1 |r|
Show InChI InChI=1S/C24H30N4O2/c1-16(25-23-20-7-5-6-8-21(20)24(29)28(4)26-23)22(27(2)3)18-11-13-19(14-12-18)30-15-17-9-10-17/h5-8,11-14,16-17,22H,9-10,15H2,1-4H3,(H,25,26)/t16-,22+/m0/s1
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n/an/a 44n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311403
PNG
(US10155764, Example 1A)
Show SMILES CN(C)[C@H](CNc1nn(C)c(=O)c2cccnc12)c1ccccc1 |r|
Show InChI InChI=1S/C18H21N5O/c1-22(2)15(13-8-5-4-6-9-13)12-20-17-16-14(10-7-11-19-16)18(24)23(3)21-17/h4-11,15H,12H2,1-3H3,(H,20,21)/t15-/m1/s1
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GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311472
PNG
(CHEM-US-00174 | US10155764, Example 54 | US1015576...)
Show SMILES CN(C)[C@H]1CCCC[C@H]1Nc1nn(C)c(=O)c2ccccc12 |r|
Show InChI InChI=1S/C17H24N4O/c1-20(2)15-11-7-6-10-14(15)18-16-12-8-4-5-9-13(12)17(22)21(3)19-16/h4-5,8-9,14-15H,6-7,10-11H2,1-3H3,(H,18,19)/t14-,15+/m1/s1
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n/an/a 45n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311505
PNG
(CHEM-US-00224 | US10155764, Example 80)
Show SMILES C[C@H](Nc1nn(C)c(=O)c2ccccc12)[C@@H](N(C)C)c1ccc(Oc2ccccn2)cc1 |r|
Show InChI InChI=1S/C25H27N5O2/c1-17(27-24-20-9-5-6-10-21(20)25(31)30(4)28-24)23(29(2)3)18-12-14-19(15-13-18)32-22-11-7-8-16-26-22/h5-17,23H,1-4H3,(H,27,28)/t17-,23+/m0/s1
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n/an/a 46n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311433
PNG
(CHEM-US-00130 | US10155764, Example 22A)
Show SMILES CN(C)[C@H](CNc1nn(C)c(=O)c2ccccc12)c1ccccc1 |r|
Show InChI InChI=1S/C19H22N4O/c1-22(2)17(14-9-5-4-6-10-14)13-20-18-15-11-7-8-12-16(15)19(24)23(3)21-18/h4-12,17H,13H2,1-3H3,(H,20,21)/t17-/m1/s1
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n/an/a 47n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311510
PNG
(CHEM-US-00230 | US10155764, Example 85)
Show SMILES CNC(=O)c1ccc(cc1)[C@@H]([C@H](C)Nc1nn(C)c(=O)c2cccnc12)N(C)C |r|
Show InChI InChI=1S/C21H26N6O2/c1-13(18(26(3)4)14-8-10-15(11-9-14)20(28)22-2)24-19-17-16(7-6-12-23-17)21(29)27(5)25-19/h6-13,18H,1-5H3,(H,22,28)(H,24,25)/t13-,18+/m0/s1
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n/an/a 50n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311509
PNG
(CHEM-US-00229 | US10155764, Example 84)
Show SMILES C[C@H](Nc1nn(C)c(=O)c2cccnc12)[C@@H](N(C)C)c1ccc(cc1)C(=O)N(C)Cc1ccccc1 |r|
Show InChI InChI=1S/C28H32N6O2/c1-19(30-26-24-23(12-9-17-29-24)28(36)34(5)31-26)25(32(2)3)21-13-15-22(16-14-21)27(35)33(4)18-20-10-7-6-8-11-20/h6-17,19,25H,18H2,1-5H3,(H,30,31)/t19-,25+/m0/s1
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n/an/a 56n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311424
PNG
(US10155764, Example 16A)
Show SMILES CN(C)[C@H]1CCC[C@H]1Nc1nn(C)c(=O)c2cccnc12 |r|
Show InChI InChI=1S/C15H21N5O/c1-19(2)12-8-4-7-11(12)17-14-13-10(6-5-9-16-13)15(21)20(3)18-14/h5-6,9,11-12H,4,7-8H2,1-3H3,(H,17,18)/t11-,12+/m1/s1
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n/an/a 57n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311507
PNG
(US10155764, Example 82)
Show SMILES C[C@H](Nc1nn(C)c(=O)c2cccnc12)[C@@H](N(C)C)c1ccc(cc1)C(=O)N1CCOCC1 |r|
Show InChI InChI=1S/C24H30N6O3/c1-16(26-22-20-19(6-5-11-25-20)24(32)29(4)27-22)21(28(2)3)17-7-9-18(10-8-17)23(31)30-12-14-33-15-13-30/h5-11,16,21H,12-15H2,1-4H3,(H,26,27)/t16-,21+/m0/s1
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n/an/a 59n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311475
PNG
(US10155764, Example 55)
Show SMILES C[C@H](Nc1nn(C)c(=O)c2ccccc12)[C@@H](N(C)C)c1ccc(cc1)S(=O)(=O)c1ccccc1 |r|
Show InChI InChI=1S/C26H28N4O3S/c1-18(27-25-22-12-8-9-13-23(22)26(31)30(4)28-25)24(29(2)3)19-14-16-21(17-15-19)34(32,33)20-10-6-5-7-11-20/h5-18,24H,1-4H3,(H,27,28)/t18-,24+/m0/s1
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n/an/a 61n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311482
PNG
(CHEM-US-00188 | US10155764, Example 62)
Show SMILES COc1ccc(cn1)[C@@H]([C@H](C)Nc1nn(C)c(=O)c2ccccc12)N(C)C |r|
Show InChI InChI=1S/C20H25N5O2/c1-13(18(24(2)3)14-10-11-17(27-5)21-12-14)22-19-15-8-6-7-9-16(15)20(26)25(4)23-19/h6-13,18H,1-5H3,(H,22,23)/t13-,18+/m0/s1
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n/an/a 63n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311431
PNG
(CHEM-US-00128 | US10155764, Example 21)
Show SMILES COc1ccc(cc1)C(CNc1nn(C)c(=O)c2ccccc12)N(C)C
Show InChI InChI=1S/C20H24N4O2/c1-23(2)18(14-9-11-15(26-4)12-10-14)13-21-19-16-7-5-6-8-17(16)20(25)24(3)22-19/h5-12,18H,13H2,1-4H3,(H,21,22)
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n/an/a 64n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311440
PNG
(CHEM-US-00137 | US10155764, Example 28)
Show SMILES CC(CN(C)C)Nc1nn(C)c(=O)c2ccccc12
Show InChI InChI=1S/C14H20N4O/c1-10(9-17(2)3)15-13-11-7-5-6-8-12(11)14(19)18(4)16-13/h5-8,10H,9H2,1-4H3,(H,15,16)
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n/an/a 66n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311444
PNG
(CHEM-US-00141 | US10155764, Example 32 | US1015576...)
Show SMILES CN(C)C1CN(CCC1Nc1nn(C)c(=O)c2cccnc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H25ClN6O/c1-26(2)18-13-28(15-8-6-14(22)7-9-15)12-10-17(18)24-20-19-16(5-4-11-23-19)21(29)27(3)25-20/h4-9,11,17-18H,10,12-13H2,1-3H3,(H,24,25)
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n/an/a 69n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311508
PNG
(CHEM-US-00228 | US10155764, Example 83)
Show SMILES C[C@H](Nc1nn(C)c(=O)c2cccnc12)[C@@H](N(C)C)c1ccc(cc1)C(=O)N1CCCC1 |r|
Show InChI InChI=1S/C24H30N6O2/c1-16(26-22-20-19(8-7-13-25-20)24(32)29(4)27-22)21(28(2)3)17-9-11-18(12-10-17)23(31)30-14-5-6-15-30/h7-13,16,21H,5-6,14-15H2,1-4H3,(H,26,27)/t16-,21+/m0/s1
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n/an/a 71n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311411
PNG
(US10155764, Example 7B)
Show SMILES C[C@H](CNc1nn(C)c(=O)c2cccnc12)N(C)C |r|
Show InChI InChI=1S/C13H19N5O/c1-9(17(2)3)8-15-12-11-10(6-5-7-14-11)13(19)18(4)16-12/h5-7,9H,8H2,1-4H3,(H,15,16)/t9-/m1/s1
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n/an/a 72n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311504
PNG
(CHEM-US-00223 | US10155764, Example 79)
Show SMILES COc1ccc(cc1)[C@@H]([C@H](C)Nc1nn(C)c(=O)c2ccccc12)N(C)C |r|
Show InChI InChI=1S/C21H26N4O2/c1-14(19(24(2)3)15-10-12-16(27-5)13-11-15)22-20-17-8-6-7-9-18(17)21(26)25(4)23-20/h6-14,19H,1-5H3,(H,22,23)/t14-,19+/m0/s1
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n/an/a 73n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311477
PNG
(CHEM-US-00183 | US10155764, Example 57)
Show SMILES C[C@H](Nc1nn(C)c(=O)c2ccccc12)[C@@H](N(C)C)c1cnn(c1)-c1ccccc1 |r|
Show InChI InChI=1S/C23H26N6O/c1-16(25-22-19-12-8-9-13-20(19)23(30)28(4)26-22)21(27(2)3)17-14-24-29(15-17)18-10-6-5-7-11-18/h5-16,21H,1-4H3,(H,25,26)/t16-,21+/m0/s1
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n/an/a 75n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311422
PNG
(US10155764, Example 15A)
Show SMILES CN(C)[C@H]1CCCC[C@H]1Nc1nn(C)c(=O)c2cccnc12 |r|
Show InChI InChI=1S/C16H23N5O/c1-20(2)13-9-5-4-8-12(13)18-15-14-11(7-6-10-17-14)16(22)21(3)19-15/h6-7,10,12-13H,4-5,8-9H2,1-3H3,(H,18,19)/t12-,13+/m1/s1
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n/an/a 78n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311513
PNG
(US10155764, Example 88)
Show SMILES C[C@H](Nc1nn(C)c(=O)c2ccccc12)[C@@H](N(C)C)c1ccc(=O)[nH]c1 |r|
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n/an/a 80n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311493
PNG
(CHEM-US-00205 | US10155764, Example 71B)
Show SMILES C[C@@H](Nc1nn(C)c(=O)c2[nH]ccc12)[C@H](N(C)C)c1ccccc1 |r|
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n/an/a 83n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311402
PNG
(US10155764, Example 1)
Show SMILES CN(C)C(CNc1nn(C)c(=O)c2cccnc12)c1ccccc1
Show InChI InChI=1S/C18H21N5O/c1-22(2)15(13-8-5-4-6-9-13)12-20-17-16-14(10-7-11-19-16)18(24)23(3)21-17/h4-11,15H,12H2,1-3H3,(H,20,21)
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n/an/a 86n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311481
PNG
(CHEM-US-00187 | US10155764, Example 61)
Show SMILES C[C@H](Nc1nn(C)c(=O)c2ccccc12)[C@@H](N(C)C)c1cccnc1 |r|
Show InChI InChI=1S/C19H23N5O/c1-13(17(23(2)3)14-8-7-11-20-12-14)21-18-15-9-5-6-10-16(15)19(25)24(4)22-18/h5-13,17H,1-4H3,(H,21,22)/t13-,17+/m0/s1
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n/an/a 86n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311409
PNG
(US10155764, Example 6)
Show SMILES CN(C)CCNc1nn(C)c(=O)c2c(F)cccc12
Show InChI InChI=1S/C13H17FN4O/c1-17(2)8-7-15-12-9-5-4-6-10(14)11(9)13(19)18(3)16-12/h4-6H,7-8H2,1-3H3,(H,15,16)
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n/an/a 87n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311455
PNG
(CHEM-US-00152 | US10155764, Example 39B)
Show SMILES CC[C@H](CNc1nn(C)c(=O)c2ccccc12)N(C)C |r|
Show InChI InChI=1S/C15H22N4O/c1-5-11(18(2)3)10-16-14-12-8-6-7-9-13(12)15(20)19(4)17-14/h6-9,11H,5,10H2,1-4H3,(H,16,17)/t11-/m1/s1
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n/an/a 89n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311506
PNG
(US10155764, Example 81)
Show SMILES C[C@H](Nc1nn(C)c(=O)c2cccnc12)[C@@H](N(C)C)c1ccc(cc1)C(O)=O |r|
Show InChI InChI=1S/C20H23N5O3/c1-12(17(24(2)3)13-7-9-14(10-8-13)20(27)28)22-18-16-15(6-5-11-21-16)19(26)25(4)23-18/h5-12,17H,1-4H3,(H,22,23)(H,27,28)/t12-,17+/m0/s1
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n/an/a 98n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311494
PNG
(CHEM-US-00206 | US10155764, Example 72)
Show SMILES C[C@H](Nc1nn(C)c(=O)c2cccnc12)[C@@H](N(C)C)c1cccc(NC(C)=O)c1 |r|
Show InChI InChI=1S/C21H26N6O2/c1-13(19(26(3)4)15-8-6-9-16(12-15)24-14(2)28)23-20-18-17(10-7-11-22-18)21(29)27(5)25-20/h6-13,19H,1-5H3,(H,23,25)(H,24,28)/t13-,19+/m0/s1
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n/an/a 99n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311430
PNG
(US10155764, Example 20)
Show SMILES CN(C)C(CNc1nn(C)c(=O)c2ccccc12)c1ccc(F)cc1
Show InChI InChI=1S/C19H21FN4O/c1-23(2)17(13-8-10-14(20)11-9-13)12-21-18-15-6-4-5-7-16(15)19(25)24(3)22-18/h4-11,17H,12H2,1-3H3,(H,21,22)
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n/an/a 110n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311472
PNG
(CHEM-US-00174 | US10155764, Example 54 | US1015576...)
Show SMILES CN(C)[C@H]1CCCC[C@H]1Nc1nn(C)c(=O)c2ccccc12 |r|
Show InChI InChI=1S/C17H24N4O/c1-20(2)15-11-7-6-10-14(15)18-16-12-8-4-5-9-13(12)17(22)21(3)19-16/h4-5,8-9,14-15H,6-7,10-11H2,1-3H3,(H,18,19)/t14-,15+/m1/s1
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n/an/a 110n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311438
PNG
(CHEM-US-00135 | US10155764, Example 26)
Show SMILES CN(C)C(CNc1nn(C)c(=O)c2ccccc12)c1ccccc1F
Show InChI InChI=1S/C19H21FN4O/c1-23(2)17(15-10-6-7-11-16(15)20)12-21-18-13-8-4-5-9-14(13)19(25)24(3)22-18/h4-11,17H,12H2,1-3H3,(H,21,22)
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n/an/a 110n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311437
PNG
(CHEM-US-00134 | US10155764, Example 25)
Show SMILES CN(C)C(CNc1nn(C)c(=O)c2ccccc12)c1ccccc1Cl
Show InChI InChI=1S/C19H21ClN4O/c1-23(2)17(15-10-6-7-11-16(15)20)12-21-18-13-8-4-5-9-14(13)19(25)24(3)22-18/h4-11,17H,12H2,1-3H3,(H,21,22)
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GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311439
PNG
(CHEM-US-00136 | US10155764, Example 27)
Show SMILES CN(C)C(CNc1nn(C)c(=O)c2ccccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H21ClN4O/c1-23(2)17(13-8-10-14(20)11-9-13)12-21-18-15-6-4-5-7-16(15)19(25)24(3)22-18/h4-11,17H,12H2,1-3H3,(H,21,22)
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n/an/a 120n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311451
PNG
(CHEM-US-00148 | US10155764, Example 37)
Show SMILES CN(C)C(CNc1nn(C)c(=O)c2CCCc12)c1ccccc1
Show InChI InChI=1S/C18H24N4O/c1-21(2)16(13-8-5-4-6-9-13)12-19-17-14-10-7-11-15(14)18(23)22(3)20-17/h4-6,8-9,16H,7,10-12H2,1-3H3,(H,19,20)
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n/an/a 130n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311408
PNG
(US10155764, Example 5)
Show SMILES CN(C)CCNc1nn(C)c(=O)c2cccc(F)c12
Show InChI InChI=1S/C13H17FN4O/c1-17(2)8-7-15-12-11-9(5-4-6-10(11)14)13(19)18(3)16-12/h4-6H,7-8H2,1-3H3,(H,15,16)
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n/an/a 130n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair
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