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Patent code US8680275

Compile Data Set for Download or QSAR

Found 351 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Orexin receptor type 2


(Homo sapiens (Human))		BDBM119642
PNG
(US8680275, 2)
Show SMILES Cc1cc(C)nc(n1)N1CC2CCN(CC12)C(=O)c1ccccc1-c1ccco1
Show InChI InChI=1S/C23H24N4O2/c1-15-12-16(2)25-23(24-15)27-13-17-9-10-26(14-20(17)27)22(28)19-7-4-3-6-18(19)21-8-5-11-29-21/h3-8,11-12,17,20H,9-10,13-14H2,1-2H3
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US Patent
 4 -44.6n/an/an/an/an/an/a4



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...

US Patent US8680275 (2014)


BindingDB Entry DOI: 10.7270/Q2WH2NPF
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))		BDBM119641
PNG
(US8680275, 1)
Show SMILES Cc1cc(C)nc(n1)N1CC2CCN(CC12)C(=O)c1ccccc1-c1cccs1
Show InChI InChI=1S/C23H24N4OS/c1-15-12-16(2)25-23(24-15)27-13-17-9-10-26(14-20(17)27)22(28)19-7-4-3-6-18(19)21-8-5-11-29-21/h3-8,11-12,17,20H,9-10,13-14H2,1-2H3
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 4 -44.6n/an/an/an/an/an/a4



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...

US Patent US8680275 (2014)


BindingDB Entry DOI: 10.7270/Q2WH2NPF
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))		BDBM119655
PNG
(US8680275, 24)
Show SMILES CCOc1ccc2ccccc2c1C(=O)N1CCC2CN(C2C1)c1nc(C)cc(C)n1
Show InChI InChI=1S/C25H28N4O2/c1-4-31-22-10-9-18-7-5-6-8-20(18)23(22)24(30)28-12-11-19-14-29(21(19)15-28)25-26-16(2)13-17(3)27-25/h5-10,13,19,21H,4,11-12,14-15H2,1-3H3
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 6 -43.6n/an/an/an/an/an/a4



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...

US Patent US8680275 (2014)


BindingDB Entry DOI: 10.7270/Q2WH2NPF
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))		BDBM119644
PNG
(US8680275, 4)
Show SMILES O=C(N1CCC2CN(C2C1)c1cnc2ccccc2n1)c1ccccc1-c1cccs1
Show InChI InChI=1S/C25H22N4OS/c30-25(19-7-2-1-6-18(19)23-10-5-13-31-23)28-12-11-17-15-29(22(17)16-28)24-14-26-20-8-3-4-9-21(20)27-24/h1-10,13-14,17,22H,11-12,15-16H2
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 7 -43.3n/an/an/an/an/an/a4



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...

US Patent US8680275 (2014)


BindingDB Entry DOI: 10.7270/Q2WH2NPF
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))		BDBM119643
PNG
(US8680275, 18 | US8680275, 3)
Show SMILES Cc1cc(C)nc(n1)N1CC2CCN(CC12)C(=O)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C25H26N4O/c1-17-14-18(2)27-25(26-17)29-15-20-12-13-28(16-23(20)29)24(30)22-11-7-6-10-21(22)19-8-4-3-5-9-19/h3-11,14,20,23H,12-13,15-16H2,1-2H3
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 8 -43.0n/an/an/an/an/an/a4



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...

US Patent US8680275 (2014)


BindingDB Entry DOI: 10.7270/Q2WH2NPF
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Homo sapiens (Human))		BDBM119645
PNG
(US8680275, 5)
Show SMILES O=C(N1CCC2CN(C2C1)c1cnc2ccccc2n1)c1ccccc1-c1ccco1
Show InChI InChI=1S/C25H22N4O2/c30-25(19-7-2-1-6-18(19)23-10-5-13-31-23)28-12-11-17-15-29(22(17)16-28)24-14-26-20-8-3-4-9-21(20)27-24/h1-10,13-14,17,22H,11-12,15-16H2
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 8 -43.0n/an/an/an/an/an/a4



Janssen Pharmaceutica NV

US Patent


Assay Description
Chinese ovary cells (CHO) stably expressing human orexin 1 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco...

US Patent US8680275 (2014)


BindingDB Entry DOI: 10.7270/Q2WH2NPF
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Homo sapiens (Human))		BDBM119644
PNG
(US8680275, 4)
Show SMILES O=C(N1CCC2CN(C2C1)c1cnc2ccccc2n1)c1ccccc1-c1cccs1
Show InChI InChI=1S/C25H22N4OS/c30-25(19-7-2-1-6-18(19)23-10-5-13-31-23)28-12-11-17-15-29(22(17)16-28)24-14-26-20-8-3-4-9-21(20)27-24/h1-10,13-14,17,22H,11-12,15-16H2
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 8 -43.0n/an/an/an/an/an/a4



Janssen Pharmaceutica NV

US Patent


Assay Description
Chinese ovary cells (CHO) stably expressing human orexin 1 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco...

US Patent US8680275 (2014)


BindingDB Entry DOI: 10.7270/Q2WH2NPF
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))		BDBM119627
PNG
(US8680275, 184)
Show SMILES Cc1cc(C)nc(n1)N1C[C@@H]2CCN(C[C@H]12)C(=O)c1cccc(F)c1-c1cc[nH]n1 |r|
Show InChI InChI=1S/C22H23FN6O/c1-13-10-14(2)26-22(25-13)29-11-15-7-9-28(12-19(15)29)21(30)16-4-3-5-17(23)20(16)18-6-8-24-27-18/h3-6,8,10,15,19H,7,9,11-12H2,1-2H3,(H,24,27)/t15-,19-/m0/s1
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 9 -42.7n/an/an/an/an/an/a4



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...

US Patent US8680275 (2014)


BindingDB Entry DOI: 10.7270/Q2WH2NPF
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))		BDBM119645
PNG
(US8680275, 5)
Show SMILES O=C(N1CCC2CN(C2C1)c1cnc2ccccc2n1)c1ccccc1-c1ccco1
Show InChI InChI=1S/C25H22N4O2/c30-25(19-7-2-1-6-18(19)23-10-5-13-31-23)28-12-11-17-15-29(22(17)16-28)24-14-26-20-8-3-4-9-21(20)27-24/h1-10,13-14,17,22H,11-12,15-16H2
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 10 -42.4n/an/an/an/an/an/a4



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...

US Patent US8680275 (2014)


BindingDB Entry DOI: 10.7270/Q2WH2NPF
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))		BDBM119675
PNG
(US8680275, 270)
Show SMILES Cc1nc(nc(C)c1C)N1C[C@@H]2CCN(C[C@H]12)C(=O)c1ccccc1-n1nccn1 |r|
Show InChI InChI=1S/C22H25N7O/c1-14-15(2)25-22(26-16(14)3)28-12-17-8-11-27(13-20(17)28)21(30)18-6-4-5-7-19(18)29-23-9-10-24-29/h4-7,9-10,17,20H,8,11-13H2,1-3H3/t17-,20-/m0/s1
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 11 -42.2n/an/an/an/an/an/a4



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...

US Patent US8680275 (2014)


BindingDB Entry DOI: 10.7270/Q2WH2NPF
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))		BDBM119660
PNG
(US8680275, 29)
Show SMILES Cc1cc(C)nc(n1)N1CC2CCN(CC12)C(=O)c1c(F)cccc1-n1nccn1
Show InChI InChI=1S/C21H22FN7O/c1-13-10-14(2)26-21(25-13)28-11-15-6-9-27(12-18(15)28)20(30)19-16(22)4-3-5-17(19)29-23-7-8-24-29/h3-5,7-8,10,15,18H,6,9,11-12H2,1-2H3
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 11 -42.2n/an/an/an/an/an/a4



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...

US Patent US8680275 (2014)


BindingDB Entry DOI: 10.7270/Q2WH2NPF
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))		BDBM119669
PNG
(US8680275, 41)
Show SMILES Cc1cc(C)nc(n1)N1CC2CCN(CC12)C(=O)c1cc(F)ccc1-n1nccn1
Show InChI InChI=1S/C21H22FN7O/c1-13-9-14(2)26-21(25-13)28-11-15-5-8-27(12-19(15)28)20(30)17-10-16(22)3-4-18(17)29-23-6-7-24-29/h3-4,6-7,9-10,15,19H,5,8,11-12H2,1-2H3
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 12 -42.0n/an/an/an/an/an/a4



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...

US Patent US8680275 (2014)


BindingDB Entry DOI: 10.7270/Q2WH2NPF
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))		BDBM119662
PNG
(US8680275, 32)
Show SMILES Cc1cc(nc(C)n1)N1CC2CCN(CC12)C(=O)c1c(F)cccc1-n1nccn1
Show InChI InChI=1S/C21H22FN7O/c1-13-10-19(26-14(2)25-13)28-11-15-6-9-27(12-18(15)28)21(30)20-16(22)4-3-5-17(20)29-23-7-8-24-29/h3-5,7-8,10,15,18H,6,9,11-12H2,1-2H3
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 13 -41.8n/an/an/an/an/an/a4



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...

US Patent US8680275 (2014)


BindingDB Entry DOI: 10.7270/Q2WH2NPF
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))		BDBM119656
PNG
(US8680275, 26)
Show SMILES Cc1ccc(c(c1)C(=O)N1CCC2CN(C2C1)c1nc(C)cc(C)n1)-n1nccn1
Show InChI InChI=1S/C22H25N7O/c1-14-4-5-19(29-23-7-8-24-29)18(10-14)21(30)27-9-6-17-12-28(20(17)13-27)22-25-15(2)11-16(3)26-22/h4-5,7-8,10-11,17,20H,6,9,12-13H2,1-3H3
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 13 -41.8n/an/an/an/an/an/a4



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...

US Patent US8680275 (2014)


BindingDB Entry DOI: 10.7270/Q2WH2NPF
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))		BDBM119661
PNG
(US8680275, 30)
Show SMILES Cc1cc(C)nc(n1)N1CC2CCN(CC12)C(=O)c1ccc(F)cc1-n1nccn1
Show InChI InChI=1S/C21H22FN7O/c1-13-9-14(2)26-21(25-13)28-11-15-5-8-27(12-19(15)28)20(30)17-4-3-16(22)10-18(17)29-23-6-7-24-29/h3-4,6-7,9-10,15,19H,5,8,11-12H2,1-2H3
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 13 -41.8n/an/an/an/an/an/a4



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...

US Patent US8680275 (2014)


BindingDB Entry DOI: 10.7270/Q2WH2NPF
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))		BDBM119639
PNG
(US8680275, 196)
Show SMILES FC(F)C(F)(F)Oc1ccccc1C(=O)N1CC[C@H]2CN([C@H]2C1)c1ccnc(n1)-c1ccccc1 |r|
Show InChI InChI=1S/C25H22F4N4O2/c26-24(27)25(28,29)35-20-9-5-4-8-18(20)23(34)32-13-11-17-14-33(19(17)15-32)21-10-12-30-22(31-21)16-6-2-1-3-7-16/h1-10,12,17,19,24H,11,13-15H2/t17-,19-/m0/s1
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 14 -41.7n/an/an/an/an/an/a4



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...

US Patent US8680275 (2014)


BindingDB Entry DOI: 10.7270/Q2WH2NPF
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Homo sapiens (Human))		BDBM119639
PNG
(US8680275, 196)
Show SMILES FC(F)C(F)(F)Oc1ccccc1C(=O)N1CC[C@H]2CN([C@H]2C1)c1ccnc(n1)-c1ccccc1 |r|
Show InChI InChI=1S/C25H22F4N4O2/c26-24(27)25(28,29)35-20-9-5-4-8-18(20)23(34)32-13-11-17-14-33(19(17)15-32)21-10-12-30-22(31-21)16-6-2-1-3-7-16/h1-10,12,17,19,24H,11,13-15H2/t17-,19-/m0/s1
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 14 -41.7n/an/an/an/an/an/a4



Janssen Pharmaceutica NV

US Patent


Assay Description
Chinese ovary cells (CHO) stably expressing human orexin 1 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco...

US Patent US8680275 (2014)


BindingDB Entry DOI: 10.7270/Q2WH2NPF
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))		BDBM119614
PNG
(US8680275, 171)
Show SMILES Cc1cc(C)nc(n1)N1C[C@@H]2CCN(C[C@H]12)C(=O)c1cc(F)ccc1-c1cc[nH]n1 |r|
Show InChI InChI=1S/C22H23FN6O/c1-13-9-14(2)26-22(25-13)29-11-15-6-8-28(12-20(15)29)21(30)18-10-16(23)3-4-17(18)19-5-7-24-27-19/h3-5,7,9-10,15,20H,6,8,11-12H2,1-2H3,(H,24,27)/t15-,20-/m0/s1
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 15 -41.5n/an/an/an/an/an/a4



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...

US Patent US8680275 (2014)


BindingDB Entry DOI: 10.7270/Q2WH2NPF
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))		BDBM119658
PNG
(US8680275, 25)
Show SMILES Cc1cc(C)nc(n1)N1CC2CCN(CC12)C(=O)c1ccccc1-n1nccn1
Show InChI InChI=1S/C21H23N7O/c1-14-11-15(2)25-21(24-14)27-12-16-7-10-26(13-19(16)27)20(29)17-5-3-4-6-18(17)28-22-8-9-23-28/h3-6,8-9,11,16,19H,7,10,12-13H2,1-2H3
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 15 -41.5n/an/an/an/an/an/a4



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...

US Patent US8680275 (2014)


BindingDB Entry DOI: 10.7270/Q2WH2NPF
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))		BDBM119578
PNG
(US8680275, 135)
Show SMILES Cc1cc(C)nc(n1)N1C[C@@H]2CCN(C[C@H]12)C(=O)c1cccc(C)c1-n1nccn1 |r|
Show InChI InChI=1S/C22H25N7O/c1-14-5-4-6-18(20(14)29-23-8-9-24-29)21(30)27-10-7-17-12-28(19(17)13-27)22-25-15(2)11-16(3)26-22/h4-6,8-9,11,17,19H,7,10,12-13H2,1-3H3/t17-,19-/m0/s1
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 15 -41.5n/an/an/an/an/an/a4



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...

US Patent US8680275 (2014)


BindingDB Entry DOI: 10.7270/Q2WH2NPF
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))		BDBM119674
PNG
(US8680275, 46)
Show SMILES CN(C)c1nc(cc(n1)C(F)(F)F)N1CC2CCN(CC12)C(=O)c1cc(F)ccc1-n1nccn1
Show InChI InChI=1S/C22H22F4N8O/c1-31(2)21-29-18(22(24,25)26)10-19(30-21)33-11-13-5-8-32(12-17(13)33)20(35)15-9-14(23)3-4-16(15)34-27-6-7-28-34/h3-4,6-7,9-10,13,17H,5,8,11-12H2,1-2H3
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 15 -41.5n/an/an/an/an/an/a4



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...

US Patent US8680275 (2014)


BindingDB Entry DOI: 10.7270/Q2WH2NPF
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))		BDBM119646
PNG
(US8680275, 7)
Show SMILES Cc1cc(C)nc(n1)N1CC2CCN(CC12)C(=O)c1ccccc1-n1cccc1
Show InChI InChI=1S/C23H25N5O/c1-16-13-17(2)25-23(24-16)28-14-18-9-12-27(15-21(18)28)22(29)19-7-3-4-8-20(19)26-10-5-6-11-26/h3-8,10-11,13,18,21H,9,12,14-15H2,1-2H3
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 15 -41.5n/an/an/an/an/an/a4



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...

US Patent US8680275 (2014)


BindingDB Entry DOI: 10.7270/Q2WH2NPF
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Homo sapiens (Human))		BDBM119638
PNG
(US8680275, 195)
Show SMILES Cc1ccc(c(c1)C(=O)N1CC[C@H]2CN([C@H]2C1)c1ccnc(n1)-c1ccccc1)C(F)(F)F |r|
Show InChI InChI=1S/C25H23F3N4O/c1-16-7-8-20(25(26,27)28)19(13-16)24(33)31-12-10-18-14-32(21(18)15-31)22-9-11-29-23(30-22)17-5-3-2-4-6-17/h2-9,11,13,18,21H,10,12,14-15H2,1H3/t18-,21-/m0/s1
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 16 -41.4n/an/an/an/an/an/a4



Janssen Pharmaceutica NV

US Patent


Assay Description
Chinese ovary cells (CHO) stably expressing human orexin 1 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco...

US Patent US8680275 (2014)


BindingDB Entry DOI: 10.7270/Q2WH2NPF
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))		BDBM119666
PNG
(US8680275, 38)
Show SMILES CN(C)c1nc(cc(n1)C(F)(F)F)N1CC2CCN(CC12)C(=O)c1ccc(F)cc1-n1nccn1
Show InChI InChI=1S/C22H22F4N8O/c1-31(2)21-29-18(22(24,25)26)10-19(30-21)33-11-13-5-8-32(12-17(13)33)20(35)15-4-3-14(23)9-16(15)34-27-6-7-28-34/h3-4,6-7,9-10,13,17H,5,8,11-12H2,1-2H3
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 16 -41.4n/an/an/an/an/an/a4



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...

US Patent US8680275 (2014)


BindingDB Entry DOI: 10.7270/Q2WH2NPF
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))		BDBM119577
PNG
(US8680275, 134)
Show SMILES COc1ccc(c(c1)C(=O)N1CC[C@H]2CN([C@H]2C1)c1nc(C)cc(C)n1)-n1nccn1 |r|
Show InChI InChI=1S/C22H25N7O2/c1-14-10-15(2)26-22(25-14)28-12-16-6-9-27(13-20(16)28)21(30)18-11-17(31-3)4-5-19(18)29-23-7-8-24-29/h4-5,7-8,10-11,16,20H,6,9,12-13H2,1-3H3/t16-,20-/m0/s1
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 16 -41.4n/an/an/an/an/an/a4



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...

US Patent US8680275 (2014)


BindingDB Entry DOI: 10.7270/Q2WH2NPF
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Homo sapiens (Human))		BDBM119675
PNG
(US8680275, 270)
Show SMILES Cc1nc(nc(C)c1C)N1C[C@@H]2CCN(C[C@H]12)C(=O)c1ccccc1-n1nccn1 |r|
Show InChI InChI=1S/C22H25N7O/c1-14-15(2)25-22(26-16(14)3)28-12-17-8-11-27(13-20(17)28)21(30)18-6-4-5-7-19(18)29-23-9-10-24-29/h4-7,9-10,17,20H,8,11-13H2,1-3H3/t17-,20-/m0/s1
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 16 -41.4n/an/an/an/an/an/a4



Janssen Pharmaceutica NV

US Patent


Assay Description
Chinese ovary cells (CHO) stably expressing human orexin 1 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco...

US Patent US8680275 (2014)


BindingDB Entry DOI: 10.7270/Q2WH2NPF
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))		BDBM119562
PNG
(US8680275, 119)
Show SMILES Clc1ccc2oc(nc2c1)N1C[C@@H]2CCN(C[C@H]12)C(=O)c1ccccc1-n1nccn1 |r|
Show InChI InChI=1S/C22H19ClN6O2/c23-15-5-6-20-17(11-15)26-22(31-20)28-12-14-7-10-27(13-19(14)28)21(30)16-3-1-2-4-18(16)29-24-8-9-25-29/h1-6,8-9,11,14,19H,7,10,12-13H2/t14-,19-/m0/s1
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 17 -41.2n/an/an/an/an/an/a4



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...

US Patent US8680275 (2014)


BindingDB Entry DOI: 10.7270/Q2WH2NPF
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))		BDBM119594
PNG
(US8680275, 151)
Show SMILES COc1ccc(c(c1)C(=O)N1CC[C@H]2CN([C@H]2C1)c1cc(C)cc(C)n1)-n1nccn1 |r|
Show InChI InChI=1S/C23H26N6O2/c1-15-10-16(2)26-22(11-15)28-13-17-6-9-27(14-21(17)28)23(30)19-12-18(31-3)4-5-20(19)29-24-7-8-25-29/h4-5,7-8,10-12,17,21H,6,9,13-14H2,1-3H3/t17-,21-/m0/s1
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 17 -41.2n/an/an/an/an/an/a4



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...

US Patent US8680275 (2014)


BindingDB Entry DOI: 10.7270/Q2WH2NPF
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))		BDBM119561
PNG
(US8680275, 117)
Show SMILES Fc1cccc(c1C(=O)N1CC[C@H]2CN([C@H]2C1)c1cnc2ccccc2n1)-n1nccn1 |r|
Show InChI InChI=1S/C23H20FN7O/c24-16-4-3-7-19(31-26-9-10-27-31)22(16)23(32)29-11-8-15-13-30(20(15)14-29)21-12-25-17-5-1-2-6-18(17)28-21/h1-7,9-10,12,15,20H,8,11,13-14H2/t15-,20-/m0/s1
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 18 -41.1n/an/an/an/an/an/a4



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...

US Patent US8680275 (2014)


BindingDB Entry DOI: 10.7270/Q2WH2NPF
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Homo sapiens (Human))		BDBM119647
PNG
(US8680275, 10)
Show SMILES Cc1ccc(cc1)-c1ccccc1C(=O)N1CCC2CN(C2C1)c1cnc2ccccc2n1
Show InChI InChI=1S/C28H26N4O/c1-19-10-12-20(13-11-19)22-6-2-3-7-23(22)28(33)31-15-14-21-17-32(26(21)18-31)27-16-29-24-8-4-5-9-25(24)30-27/h2-13,16,21,26H,14-15,17-18H2,1H3
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 18 -41.1n/an/an/an/an/an/a4



Janssen Pharmaceutica NV

US Patent


Assay Description
Chinese ovary cells (CHO) stably expressing human orexin 1 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco...

US Patent US8680275 (2014)


BindingDB Entry DOI: 10.7270/Q2WH2NPF
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))		BDBM119667
PNG
(US8680275, 39)
Show SMILES O=C(N1CCC2CN(C2C1)c1cnc2ccccc2n1)c1ccccc1-n1nccn1
Show InChI InChI=1S/C23H21N7O/c31-23(17-5-1-4-8-20(17)30-25-10-11-26-30)28-12-9-16-14-29(21(16)15-28)22-13-24-18-6-2-3-7-19(18)27-22/h1-8,10-11,13,16,21H,9,12,14-15H2
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 20 -40.8n/an/an/an/an/an/a4



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...

US Patent US8680275 (2014)


BindingDB Entry DOI: 10.7270/Q2WH2NPF
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))		BDBM119654
PNG
(US8680275, 23)
Show SMILES Cc1cc(C)nc(n1)N1CC2CCN(CC12)C(=O)c1cc(F)ccc1-c1ncccn1
Show InChI InChI=1S/C23H23FN6O/c1-14-10-15(2)28-23(27-14)30-12-16-6-9-29(13-20(16)30)22(31)19-11-17(24)4-5-18(19)21-25-7-3-8-26-21/h3-5,7-8,10-11,16,20H,6,9,12-13H2,1-2H3
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 20 -40.8n/an/an/an/an/an/a4



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...

US Patent US8680275 (2014)


BindingDB Entry DOI: 10.7270/Q2WH2NPF
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))		BDBM119659
PNG
(US8680275, 28)
Show SMILES Cc1cc(C)nc(n1)N1CC2CCN(CC12)C(=O)c1ccccc1-c1ncccn1
Show InChI InChI=1S/C23H24N6O/c1-15-12-16(2)27-23(26-15)29-13-17-8-11-28(14-20(17)29)22(30)19-7-4-3-6-18(19)21-24-9-5-10-25-21/h3-7,9-10,12,17,20H,8,11,13-14H2,1-2H3
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 21 -40.7n/an/an/an/an/an/a4



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...

US Patent US8680275 (2014)


BindingDB Entry DOI: 10.7270/Q2WH2NPF
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Homo sapiens (Human))		BDBM119485
PNG
(US8680275, 9)
Show SMILES O=C(N1CCC2CN(C2C1)c1nccc(n1)-c1ccccc1)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C29H26N4O/c34-28(25-14-8-7-13-24(25)21-9-3-1-4-10-21)32-18-16-23-19-33(27(23)20-32)29-30-17-15-26(31-29)22-11-5-2-6-12-22/h1-15,17,23,27H,16,18-20H2
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 22 -40.6n/an/an/an/an/an/a4



Janssen Pharmaceutica NV

US Patent


Assay Description
Chinese ovary cells (CHO) stably expressing human orexin 1 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco...

US Patent US8680275 (2014)


BindingDB Entry DOI: 10.7270/Q2WH2NPF
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Homo sapiens (Human))		BDBM119561
PNG
(US8680275, 117)
Show SMILES Fc1cccc(c1C(=O)N1CC[C@H]2CN([C@H]2C1)c1cnc2ccccc2n1)-n1nccn1 |r|
Show InChI InChI=1S/C23H20FN7O/c24-16-4-3-7-19(31-26-9-10-27-31)22(16)23(32)29-11-8-15-13-30(20(15)14-29)21-12-25-17-5-1-2-6-18(17)28-21/h1-7,9-10,12,15,20H,8,11,13-14H2/t15-,20-/m0/s1
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 23 -40.5n/an/an/an/an/an/a4



Janssen Pharmaceutica NV

US Patent


Assay Description
Chinese ovary cells (CHO) stably expressing human orexin 1 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco...

US Patent US8680275 (2014)


BindingDB Entry DOI: 10.7270/Q2WH2NPF
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Homo sapiens (Human))		BDBM119560
PNG
(US8680275, 116)
Show SMILES Fc1cccc(C(=O)N2CC[C@H]3CN([C@H]3C2)c2cnc3ccccc3n2)c1-n1nccn1 |r|
Show InChI InChI=1S/C23H20FN7O/c24-17-5-3-4-16(22(17)31-26-9-10-27-31)23(32)29-11-8-15-13-30(20(15)14-29)21-12-25-18-6-1-2-7-19(18)28-21/h1-7,9-10,12,15,20H,8,11,13-14H2/t15-,20-/m0/s1
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 23 -40.5n/an/an/an/an/an/a4



Janssen Pharmaceutica NV

US Patent


Assay Description
Chinese ovary cells (CHO) stably expressing human orexin 1 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco...

US Patent US8680275 (2014)


BindingDB Entry DOI: 10.7270/Q2WH2NPF
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))		BDBM119539
PNG
(US8680275, 95)
Show SMILES Fc1cccc(c1C(=O)N1CC[C@H]2CN([C@H]2C1)c1nccc(n1)C(F)(F)F)-n1nccn1 |r|
Show InChI InChI=1S/C20H17F4N7O/c21-13-2-1-3-14(31-26-7-8-27-31)17(13)18(32)29-9-5-12-10-30(15(12)11-29)19-25-6-4-16(28-19)20(22,23)24/h1-4,6-8,12,15H,5,9-11H2/t12-,15-/m0/s1
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 23 -40.5n/an/an/an/an/an/a4



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...

US Patent US8680275 (2014)


BindingDB Entry DOI: 10.7270/Q2WH2NPF
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Homo sapiens (Human))		BDBM119484
PNG
(US8680275, 17 | US8680275, 8)
Show SMILES O=C(N1CCC2CN(C2C1)c1cnc2ccccc2n1)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C27H24N4O/c32-27(22-11-5-4-10-21(22)19-8-2-1-3-9-19)30-15-14-20-17-31(25(20)18-30)26-16-28-23-12-6-7-13-24(23)29-26/h1-13,16,20,25H,14-15,17-18H2
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 24 -40.4n/an/an/an/an/an/a4



Janssen Pharmaceutica NV

US Patent


Assay Description
Chinese ovary cells (CHO) stably expressing human orexin 1 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco...

US Patent US8680275 (2014)


BindingDB Entry DOI: 10.7270/Q2WH2NPF
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))		BDBM119665
PNG
(US8680275, 35)
Show SMILES Cc1cc(nc(n1)C(F)(F)F)N1CC2CCN(CC12)C(=O)c1ccccc1-n1nccn1
Show InChI InChI=1S/C21H20F3N7O/c1-13-10-18(28-20(27-13)21(22,23)24)30-11-14-6-9-29(12-17(14)30)19(32)15-4-2-3-5-16(15)31-25-7-8-26-31/h2-5,7-8,10,14,17H,6,9,11-12H2,1H3
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 24 -40.4n/an/an/an/an/an/a4



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...

US Patent US8680275 (2014)


BindingDB Entry DOI: 10.7270/Q2WH2NPF
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))		BDBM119484
PNG
(US8680275, 17 | US8680275, 8)
Show SMILES O=C(N1CCC2CN(C2C1)c1cnc2ccccc2n1)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C27H24N4O/c32-27(22-11-5-4-10-21(22)19-8-2-1-3-9-19)30-15-14-20-17-31(25(20)18-30)26-16-28-23-12-6-7-13-24(23)29-26/h1-13,16,20,25H,14-15,17-18H2
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 24 -40.4n/an/an/an/an/an/a4



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...

US Patent US8680275 (2014)


BindingDB Entry DOI: 10.7270/Q2WH2NPF
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))		BDBM119571
PNG
(US8680275, 128)
Show SMILES Cc1cc(C)nc(c1)N1C[C@@H]2CCN(C[C@H]12)C(=O)c1cc(F)ccc1-n1nccn1 |r|
Show InChI InChI=1S/C22H23FN6O/c1-14-9-15(2)26-21(10-14)28-12-16-5-8-27(13-20(16)28)22(30)18-11-17(23)3-4-19(18)29-24-6-7-25-29/h3-4,6-7,9-11,16,20H,5,8,12-13H2,1-2H3/t16-,20-/m0/s1
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 26 -40.2n/an/an/an/an/an/a4



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...

US Patent US8680275 (2014)


BindingDB Entry DOI: 10.7270/Q2WH2NPF
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))		BDBM119563
PNG
(US8680275, 120)
Show SMILES Fc1cccc(c1C(=O)N1CC[C@H]2CN([C@H]2C1)c1nc2cc(Cl)ccc2o1)-n1nccn1 |r|
Show InChI InChI=1S/C22H18ClFN6O2/c23-14-4-5-19-16(10-14)27-22(32-19)29-11-13-6-9-28(12-18(13)29)21(31)20-15(24)2-1-3-17(20)30-25-7-8-26-30/h1-5,7-8,10,13,18H,6,9,11-12H2/t13-,18-/m0/s1
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 26 -40.2n/an/an/an/an/an/a4



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...

US Patent US8680275 (2014)


BindingDB Entry DOI: 10.7270/Q2WH2NPF
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))		BDBM119657
PNG
(US8680275, 27)
Show SMILES Cc1ccc(-c2ncccn2)c(c1)C(=O)N1CCC2CN(C2C1)c1nc(C)cc(C)n1
Show InChI InChI=1S/C24H26N6O/c1-15-5-6-19(22-25-8-4-9-26-22)20(11-15)23(31)29-10-7-18-13-30(21(18)14-29)24-27-16(2)12-17(3)28-24/h4-6,8-9,11-12,18,21H,7,10,13-14H2,1-3H3
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 28 -40.1n/an/an/an/an/an/a4



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...

US Patent US8680275 (2014)


BindingDB Entry DOI: 10.7270/Q2WH2NPF
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))		BDBM119638
PNG
(US8680275, 195)
Show SMILES Cc1ccc(c(c1)C(=O)N1CC[C@H]2CN([C@H]2C1)c1ccnc(n1)-c1ccccc1)C(F)(F)F |r|
Show InChI InChI=1S/C25H23F3N4O/c1-16-7-8-20(25(26,27)28)19(13-16)24(33)31-12-10-18-14-32(21(18)15-31)22-9-11-29-23(30-22)17-5-3-2-4-6-17/h2-9,11,13,18,21H,10,12,14-15H2,1H3/t18-,21-/m0/s1
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 28 -40.1n/an/an/an/an/an/a4



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...

US Patent US8680275 (2014)


BindingDB Entry DOI: 10.7270/Q2WH2NPF
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))		BDBM119560
PNG
(US8680275, 116)
Show SMILES Fc1cccc(C(=O)N2CC[C@H]3CN([C@H]3C2)c2cnc3ccccc3n2)c1-n1nccn1 |r|
Show InChI InChI=1S/C23H20FN7O/c24-17-5-3-4-16(22(17)31-26-9-10-27-31)23(32)29-11-8-15-13-30(20(15)14-29)21-12-25-18-6-1-2-7-19(18)28-21/h1-7,9-10,12,15,20H,8,11,13-14H2/t15-,20-/m0/s1
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 28 -40.1n/an/an/an/an/an/a4



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...

US Patent US8680275 (2014)


BindingDB Entry DOI: 10.7270/Q2WH2NPF
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))		BDBM119502
PNG
(US8680275, 57)
Show SMILES Cc1cc(C)nc(n1)N1CC2CN(CC12)C(=O)c1ccccc1-c1cccs1
Show InChI InChI=1S/C22H22N4OS/c1-14-10-15(2)24-22(23-14)26-12-16-11-25(13-19(16)26)21(27)18-7-4-3-6-17(18)20-8-5-9-28-20/h3-10,16,19H,11-13H2,1-2H3
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 29 -40.0n/an/an/an/an/an/a4



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...

US Patent US8680275 (2014)


BindingDB Entry DOI: 10.7270/Q2WH2NPF
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))		BDBM119653
PNG
(US8680275, 22)
Show SMILES Cc1cc(C)nc(n1)N1CC2CCN(CC12)C(=O)c1c(F)cccc1-c1ncccn1
Show InChI InChI=1S/C23H23FN6O/c1-14-11-15(2)28-23(27-14)30-12-16-7-10-29(13-19(16)30)22(31)20-17(5-3-6-18(20)24)21-25-8-4-9-26-21/h3-6,8-9,11,16,19H,7,10,12-13H2,1-2H3
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 29 -40.0n/an/an/an/an/an/a4



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...

US Patent US8680275 (2014)


BindingDB Entry DOI: 10.7270/Q2WH2NPF
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))		BDBM119573
PNG
(US8680275, 130)
Show SMILES Fc1ccc(c(c1)C(=O)N1CC[C@H]2CN([C@H]2C1)c1cc(ccn1)C(F)(F)F)-n1nccn1 |r|
Show InChI InChI=1S/C21H18F4N6O/c22-15-1-2-17(31-27-6-7-28-31)16(10-15)20(32)29-8-4-13-11-30(18(13)12-29)19-9-14(3-5-26-19)21(23,24)25/h1-3,5-7,9-10,13,18H,4,8,11-12H2/t13-,18-/m0/s1
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 31 -39.8n/an/an/an/an/an/a4



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...

US Patent US8680275 (2014)


BindingDB Entry DOI: 10.7270/Q2WH2NPF
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Homo sapiens (Human))		BDBM119562
PNG
(US8680275, 119)
Show SMILES Clc1ccc2oc(nc2c1)N1C[C@@H]2CCN(C[C@H]12)C(=O)c1ccccc1-n1nccn1 |r|
Show InChI InChI=1S/C22H19ClN6O2/c23-15-5-6-20-17(11-15)26-22(31-20)28-12-14-7-10-27(13-19(14)28)21(30)16-3-1-2-4-18(16)29-24-8-9-25-29/h1-6,8-9,11,14,19H,7,10,12-13H2/t14-,19-/m0/s1
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 32 -39.8n/an/an/an/an/an/a4



Janssen Pharmaceutica NV

US Patent


Assay Description
Chinese ovary cells (CHO) stably expressing human orexin 1 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco...

US Patent US8680275 (2014)


BindingDB Entry DOI: 10.7270/Q2WH2NPF
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Homo sapiens (Human))		BDBM119667
PNG
(US8680275, 39)
Show SMILES O=C(N1CCC2CN(C2C1)c1cnc2ccccc2n1)c1ccccc1-n1nccn1
Show InChI InChI=1S/C23H21N7O/c31-23(17-5-1-4-8-20(17)30-25-10-11-26-30)28-12-9-16-14-29(21(16)15-28)22-13-24-18-6-2-3-7-19(18)27-22/h1-8,10-11,13,16,21H,9,12,14-15H2
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 32 -39.8n/an/an/an/an/an/a4



Janssen Pharmaceutica NV

US Patent


Assay Description
Chinese ovary cells (CHO) stably expressing human orexin 1 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco...

US Patent US8680275 (2014)


BindingDB Entry DOI: 10.7270/Q2WH2NPF
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 351 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%