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PubMed code 18950149

Compile data set for download or QSAR
Found 75 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50377986
PNG
(CHEMBL483406 | UR-AK24)
Show SMILES CC(CC(=O)NC(N)=NCCCc1cnc[nH]1)c1ccccc1 |w:8.8|
Show InChI InChI=1S/C17H23N5O/c1-13(14-6-3-2-4-7-14)10-16(23)22-17(18)20-9-5-8-15-11-19-12-21-15/h2-4,6-7,11-13H,5,8-10H2,1H3,(H,19,21)(H3,18,20,22,23)
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n/an/an/an/a 15.3n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Activity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-s...


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM86741
PNG
(UR-AK59)
Show SMILES CC(C1CCCCC1)C(=O)NC(N)=NCCCc1cnc[nH]1 |w:13.14|
Show InChI InChI=1S/C16H27N5O/c1-12(13-6-3-2-4-7-13)15(22)21-16(17)19-9-5-8-14-10-18-11-20-14/h10-13H,2-9H2,1H3,(H,18,20)(H3,17,19,21,22)
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n/an/an/a 2.34E+3n/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50275884
PNG
(CHEMBL471413 | N1-(3,3-Diphenylpropanoyl)-N2-[3-(1...)
Show SMILES NC(NC(=O)CC(c1ccccc1)c1ccccc1)=NCCCc1cnc[nH]1 |w:19.21|
Show InChI InChI=1S/C22H25N5O/c23-22(25-13-7-12-19-15-24-16-26-19)27-21(28)14-20(17-8-3-1-4-9-17)18-10-5-2-6-11-18/h1-6,8-11,15-16,20H,7,12-14H2,(H,24,26)(H3,23,25,27,28)
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n/an/an/a 741n/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50275983
PNG
(CHEMBL472441 | N1-[3-(1H-Imidazol-4-yl)propyl]-N2-...)
Show SMILES NC(NC(=O)CC(c1nccs1)c1ccccc1)=NCCCc1cnc[nH]1 |w:18.20|
Show InChI InChI=1S/C19H22N6OS/c20-19(23-8-4-7-15-12-21-13-24-15)25-17(26)11-16(18-22-9-10-27-18)14-5-2-1-3-6-14/h1-3,5-6,9-10,12-13,16H,4,7-8,11H2,(H,21,24)(H3,20,23,25,26)
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n/an/an/a 4.68E+3n/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50413176
PNG
(CHEMBL513883)
Show SMILES NC(NC(=O)CC(c1ccc(F)cc1)c1ccc(F)cc1)=NCCCc1cnc[nH]1 |w:21.23|
Show InChI InChI=1S/C22H23F2N5O/c23-17-7-3-15(4-8-17)20(16-5-9-18(24)10-6-16)12-21(30)29-22(25)27-11-1-2-19-13-26-14-28-19/h3-10,13-14,20H,1-2,11-12H2,(H,26,28)(H3,25,27,29,30)
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n/an/an/an/a 204n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50413177
PNG
(CHEMBL513039)
Show SMILES NC(NC(=O)CC(c1nccn1Cc1ccccc1)c1ccc(F)c(F)c1)=NCCCc1cnc[nH]1 |w:27.30|
Show InChI InChI=1S/C26H27F2N7O/c27-22-9-8-19(13-23(22)28)21(25-31-11-12-35(25)16-18-5-2-1-3-6-18)14-24(36)34-26(29)32-10-4-7-20-15-30-17-33-20/h1-3,5-6,8-9,11-13,15,17,21H,4,7,10,14,16H2,(H,30,33)(H3,29,32,34,36)
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n/an/an/an/a 398n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50413184
PNG
(CHEMBL469748)
Show SMILES NC(NC(=O)C(c1ccccc1)c1ccccc1)=NCCCc1cnc[nH]1 |w:18.20|
Show InChI InChI=1S/C21H23N5O/c22-21(24-13-7-12-18-14-23-15-25-18)26-20(27)19(16-8-3-1-4-9-16)17-10-5-2-6-11-17/h1-6,8-11,14-15,19H,7,12-13H2,(H,23,25)(H3,22,24,26,27)
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n/an/an/an/a 1.05E+3n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50413185
PNG
(CHEMBL449828)
Show SMILES CC(CCN=C(N)NC(=O)CCc1cnc[nH]1)c1ccccc1 |w:4.3|
Show InChI InChI=1S/C17H23N5O/c1-13(14-5-3-2-4-6-14)9-10-20-17(18)22-16(23)8-7-15-11-19-12-21-15/h2-6,11-13H,7-10H2,1H3,(H,19,21)(H3,18,20,22,23)
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n/an/an/an/a 6.46E+3n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as inhibition of histamine-induced positive ch...


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM7966
PNG
(2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...)
Show SMILES NCCc1cnc[nH]1
Show InChI InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
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n/an/an/an/a 190n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assay


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM7966
PNG
(2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...)
Show SMILES NCCc1cnc[nH]1
Show InChI InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
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n/an/an/an/a 1.20E+3n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Activity at guinea pig recombinant histamine H2 receptor-Gsalpha fusion protein expressed in Sf9 cells by steady-state GTPase activity assay


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50275983
PNG
(CHEMBL472441 | N1-[3-(1H-Imidazol-4-yl)propyl]-N2-...)
Show SMILES NC(NC(=O)CC(c1nccs1)c1ccccc1)=NCCCc1cnc[nH]1 |w:18.20|
Show InChI InChI=1S/C19H22N6OS/c20-19(23-8-4-7-15-12-21-13-24-15)25-17(26)11-16(18-22-9-10-27-18)14-5-2-1-3-6-14/h1-3,5-6,9-10,12-13,16H,4,7-8,11H2,(H,21,24)(H3,20,23,25,26)
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n/an/an/an/a 14n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Activity at guinea pig recombinant histamine H2 receptor-Gsalpha fusion protein expressed in Sf9 cells by steady-state GTPase activity assay


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50276073
PNG
(CHEMBL502339 | N1-[3-(1H-Imidazol-4-yl)propyl]-N2-...)
Show SMILES CC(CC(=O)NC(N)=NCCCc1cnc[nH]1)c1cccs1 |w:8.8|
Show InChI InChI=1S/C15H21N5OS/c1-11(13-5-3-7-22-13)8-14(21)20-15(16)18-6-2-4-12-9-17-10-19-12/h3,5,7,9-11H,2,4,6,8H2,1H3,(H,17,19)(H3,16,18,20,21)
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n/an/an/an/a 21n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Activity at guinea pig recombinant histamine H2 receptor-Gsalpha fusion protein expressed in Sf9 cells by steady-state GTPase activity assay


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM7966
PNG
(2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...)
Show SMILES NCCc1cnc[nH]1
Show InChI InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
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n/an/an/an/a 11.6n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Activity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-s...


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM7966
PNG
(2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...)
Show SMILES NCCc1cnc[nH]1
Show InChI InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
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n/an/an/an/a 1.00E+3n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50275983
PNG
(CHEMBL472441 | N1-[3-(1H-Imidazol-4-yl)propyl]-N2-...)
Show SMILES NC(NC(=O)CC(c1nccs1)c1ccccc1)=NCCCc1cnc[nH]1 |w:18.20|
Show InChI InChI=1S/C19H22N6OS/c20-19(23-8-4-7-15-12-21-13-24-15)25-17(26)11-16(18-22-9-10-27-18)14-5-2-1-3-6-14/h1-3,5-6,9-10,12-13,16H,4,7-8,11H2,(H,21,24)(H3,20,23,25,26)
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n/an/an/an/a 38.0n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM86737
PNG
(UR-AK22)
Show SMILES NC(NC(=O)CCCCc1ccccc1)=NCCCc1cnc[nH]1 |w:15.16|
Show InChI InChI=1S/C18H25N5O/c19-18(21-12-6-10-16-13-20-14-22-16)23-17(24)11-5-4-9-15-7-2-1-3-8-15/h1-3,7-8,13-14H,4-6,9-12H2,(H,20,22)(H3,19,21,23,24)
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n/an/an/an/a 468n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50413174
PNG
(CHEMBL513755)
Show SMILES NC(NC(=O)CC(c1nccs1)c1ccc(F)c(F)c1)=NCCCc1cnc[nH]1 |w:20.22|
Show InChI InChI=1S/C19H20F2N6OS/c20-15-4-3-12(8-16(15)21)14(18-24-6-7-29-18)9-17(28)27-19(22)25-5-1-2-13-10-23-11-26-13/h3-4,6-8,10-11,14H,1-2,5,9H2,(H,23,26)(H3,22,25,27,28)
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n/an/an/an/a 50.1n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM86742
PNG
(UR-AK64)
Show SMILES NC(NC(=O)CCCC1CCCCC1)=NCCCc1cnc[nH]1 |w:14.15|
Show InChI InChI=1S/C17H29N5O/c18-17(20-11-5-9-15-12-19-13-21-15)22-16(23)10-4-8-14-6-2-1-3-7-14/h12-14H,1-11H2,(H,19,21)(H3,18,20,22,23)
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n/an/an/an/a 372n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM86740
PNG
(UR-AK24 | UR-AK57)
Show SMILES CC(CC(=O)NC(N)=NCCCc1cnc[nH]1)C1CCCCC1 |w:8.8|
Show InChI InChI=1S/C17H29N5O/c1-13(14-6-3-2-4-7-14)10-16(23)22-17(18)20-9-5-8-15-11-19-12-21-15/h11-14H,2-10H2,1H3,(H,19,21)(H3,18,20,22,23)
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n/an/an/an/a 67.6n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50377986
PNG
(CHEMBL483406 | UR-AK24)
Show SMILES CC(CC(=O)NC(N)=NCCCc1cnc[nH]1)c1ccccc1 |w:8.8|
Show InChI InChI=1S/C17H23N5O/c1-13(14-6-3-2-4-7-14)10-16(23)22-17(18)20-9-5-8-15-11-19-12-21-15/h2-4,6-7,11-13H,5,8-10H2,1H3,(H,19,21)(H3,18,20,22,23)
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n/an/an/a 1.35E+3n/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50413183
PNG
(CHEMBL470563)
Show SMILES NC(NC(=O)CC(c1ncc[nH]1)c1ccc(F)c(F)c1)=NCCCc1cnc[nH]1 |w:20.22|
Show InChI InChI=1S/C19H21F2N7O/c20-15-4-3-12(8-16(15)21)14(18-24-6-7-25-18)9-17(29)28-19(22)26-5-1-2-13-10-23-11-27-13/h3-4,6-8,10-11,14H,1-2,5,9H2,(H,23,27)(H,24,25)(H3,22,26,28,29)
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n/an/an/an/a 97.7n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50413181
PNG
(CHEMBL499301)
Show SMILES NC(NC(=O)CC(c1ccccc1)c1ccccc1)=NCCc1cnc[nH]1 |w:19.21|
Show InChI InChI=1S/C21H23N5O/c22-21(24-12-11-18-14-23-15-25-18)26-20(27)13-19(16-7-3-1-4-8-16)17-9-5-2-6-10-17/h1-10,14-15,19H,11-13H2,(H,23,25)(H3,22,24,26,27)
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n/an/an/an/a 646n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50275884
PNG
(CHEMBL471413 | N1-(3,3-Diphenylpropanoyl)-N2-[3-(1...)
Show SMILES NC(NC(=O)CC(c1ccccc1)c1ccccc1)=NCCCc1cnc[nH]1 |w:19.21|
Show InChI InChI=1S/C22H25N5O/c23-22(25-13-7-12-19-15-24-16-26-19)27-21(28)14-20(17-8-3-1-4-9-17)18-10-5-2-6-11-18/h1-6,8-11,15-16,20H,7,12-14H2,(H,24,26)(H3,23,25,27,28)
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n/an/an/an/a 6n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Activity at guinea pig recombinant histamine H2 receptor-Gsalpha fusion protein expressed in Sf9 cells by steady-state GTPase activity assay


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50275983
PNG
(CHEMBL472441 | N1-[3-(1H-Imidazol-4-yl)propyl]-N2-...)
Show SMILES NC(NC(=O)CC(c1nccs1)c1ccccc1)=NCCCc1cnc[nH]1 |w:18.20|
Show InChI InChI=1S/C19H22N6OS/c20-19(23-8-4-7-15-12-21-13-24-15)25-17(26)11-16(18-22-9-10-27-18)14-5-2-1-3-6-14/h1-3,5-6,9-10,12-13,16H,4,7-8,11H2,(H,21,24)(H3,20,23,25,26)
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n/an/an/an/a 66.3n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Activity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-s...


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM86747
PNG
(UR-AK67)
Show SMILES NC(NC(=O)CCCc1ccccc1)=NCCCc1cnc[nH]1 |w:14.15|
Show InChI InChI=1S/C17H23N5O/c18-17(20-11-5-9-15-12-19-13-21-15)22-16(23)10-4-8-14-6-2-1-3-7-14/h1-3,6-7,12-13H,4-5,8-11H2,(H,19,21)(H3,18,20,22,23)
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n/an/an/a 1.82E+3n/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM86743
PNG
(UR-AK49)
Show SMILES NC(NC(=O)CCC1CCCCC1)=NCCCc1cnc[nH]1 |w:13.14|
Show InChI InChI=1S/C16H27N5O/c17-16(19-10-4-7-14-11-18-12-20-14)21-15(22)9-8-13-5-2-1-3-6-13/h11-13H,1-10H2,(H,18,20)(H3,17,19,21,22)
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n/an/an/a 6.17E+3n/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM7966
PNG
(2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...)
Show SMILES NCCc1cnc[nH]1
Show InChI InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
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n/an/an/an/a 1.20E+3n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Activity at human recombinant histamine H2 receptor-Gsalpha fusion protein expressed in Sf9 cells by steady-state GTPase activity assay


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50275983
PNG
(CHEMBL472441 | N1-[3-(1H-Imidazol-4-yl)propyl]-N2-...)
Show SMILES NC(NC(=O)CC(c1nccs1)c1ccccc1)=NCCCc1cnc[nH]1 |w:18.20|
Show InChI InChI=1S/C19H22N6OS/c20-19(23-8-4-7-15-12-21-13-24-15)25-17(26)11-16(18-22-9-10-27-18)14-5-2-1-3-6-14/h1-3,5-6,9-10,12-13,16H,4,7-8,11H2,(H,21,24)(H3,20,23,25,26)
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n/an/an/an/a 120n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Activity at human recombinant histamine H2 receptor-Gsalpha fusion protein expressed in Sf9 cells by steady-state GTPase activity assay


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50377986
PNG
(CHEMBL483406 | UR-AK24)
Show SMILES CC(CC(=O)NC(N)=NCCCc1cnc[nH]1)c1ccccc1 |w:8.8|
Show InChI InChI=1S/C17H23N5O/c1-13(14-6-3-2-4-7-14)10-16(23)22-17(18)20-9-5-8-15-11-19-12-21-15/h2-4,6-7,11-13H,5,8-10H2,1H3,(H,19,21)(H3,18,20,22,23)
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n/an/an/an/a 67n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Activity at human recombinant histamine H2 receptor-Gsalpha fusion protein expressed in Sf9 cells by steady-state GTPase activity assay


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50276073
PNG
(CHEMBL502339 | N1-[3-(1H-Imidazol-4-yl)propyl]-N2-...)
Show SMILES CC(CC(=O)NC(N)=NCCCc1cnc[nH]1)c1cccs1 |w:8.8|
Show InChI InChI=1S/C15H21N5OS/c1-11(13-5-3-7-22-13)8-14(21)20-15(16)18-6-2-4-12-9-17-10-19-12/h3,5,7,9-11H,2,4,6,8H2,1H3,(H,17,19)(H3,16,18,20,21)
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n/an/an/an/a 6.30n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Activity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-s...


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50413175
PNG
(CHEMBL501589)
Show SMILES CC(CC(=O)NC(N)=NCCCc1cnc[nH]1)c1ccccn1 |w:8.8|
Show InChI InChI=1S/C16H22N6O/c1-12(14-6-2-3-7-19-14)9-15(23)22-16(17)20-8-4-5-13-10-18-11-21-13/h2-3,6-7,10-12H,4-5,8-9H2,1H3,(H,18,21)(H3,17,20,22,23)
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n/an/an/an/a 38.0n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM86744
PNG
(UR-AK62)
Show SMILES NC(NC(=O)CC1CCCCC1)=NCCCc1cnc[nH]1 |w:12.13|
Show InChI InChI=1S/C15H25N5O/c16-15(18-8-4-7-13-10-17-11-19-13)20-14(21)9-12-5-2-1-3-6-12/h10-12H,1-9H2,(H,17,19)(H3,16,18,20,21)
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n/an/an/an/a 100n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50413182
PNG
(CHEMBL472039)
Show SMILES CC(CC(=O)NC(N)=NCCCc1cnc[nH]1)c1nccs1 |w:8.8|
Show InChI InChI=1S/C14H20N6OS/c1-10(13-17-5-6-22-13)7-12(21)20-14(15)18-4-2-3-11-8-16-9-19-11/h5-6,8-10H,2-4,7H2,1H3,(H,16,19)(H3,15,18,20,21)
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n/an/an/an/a 38.9n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM86743
PNG
(UR-AK49)
Show SMILES NC(NC(=O)CCC1CCCCC1)=NCCCc1cnc[nH]1 |w:13.14|
Show InChI InChI=1S/C16H27N5O/c17-16(19-10-4-7-14-11-18-12-20-14)21-15(22)9-8-13-5-2-1-3-6-13/h11-13H,1-10H2,(H,18,20)(H3,17,19,21,22)
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n/an/an/an/a 61.7n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM86739
PNG
(UR-AK41)
Show SMILES NC(NC(=O)c1ccccc1)=NCCCc1cnc[nH]1 |w:11.12|
Show InChI InChI=1S/C14H17N5O/c15-14(17-8-4-7-12-9-16-10-18-12)19-13(20)11-5-2-1-3-6-11/h1-3,5-6,9-10H,4,7-8H2,(H,16,18)(H3,15,17,19,20)
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n/an/an/an/a 1.17E+3n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM86736
PNG
(UR-AK68)
Show SMILES CC(C(=O)NC(N)=NCCCc1cnc[nH]1)c1ccccc1 |w:7.7|
Show InChI InChI=1S/C16H21N5O/c1-12(13-6-3-2-4-7-13)15(22)21-16(17)19-9-5-8-14-10-18-11-20-14/h2-4,6-7,10-12H,5,8-9H2,1H3,(H,18,20)(H3,17,19,21,22)
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n/an/an/an/a 3.63E+3n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50377986
PNG
(CHEMBL483406 | UR-AK24)
Show SMILES CC(CC(=O)NC(N)=NCCCc1cnc[nH]1)c1ccccc1 |w:8.8|
Show InChI InChI=1S/C17H23N5O/c1-13(14-6-3-2-4-7-14)10-16(23)22-17(18)20-9-5-8-15-11-19-12-21-15/h2-4,6-7,11-13H,5,8-10H2,1H3,(H,19,21)(H3,18,20,22,23)
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n/an/an/an/a 2.45n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Activity at human recombinant histamine H3 receptor expressed in Sf9 cells coexpressing Galphai, G-beta-1-gamma-2 and RGS4 by steady-state GTPase act...


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM86742
PNG
(UR-AK64)
Show SMILES NC(NC(=O)CCCC1CCCCC1)=NCCCc1cnc[nH]1 |w:14.15|
Show InChI InChI=1S/C17H29N5O/c18-17(20-11-5-9-15-12-19-13-21-15)22-16(23)10-4-8-14-6-2-1-3-7-14/h12-14H,1-11H2,(H,19,21)(H3,18,20,22,23)
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n/an/an/a 741n/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50413172
PNG
(CHEMBL512716)
Show SMILES NC(NC(=O)CC(c1ccccc1)c1ccc(F)c(F)c1)=NCCCc1cnc[nH]1 |w:21.23|
Show InChI InChI=1S/C22H23F2N5O/c23-19-9-8-16(11-20(19)24)18(15-5-2-1-3-6-15)12-21(30)29-22(25)27-10-4-7-17-13-26-14-28-17/h1-3,5-6,8-9,11,13-14,18H,4,7,10,12H2,(H,26,28)(H3,25,27,29,30)
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n/an/an/an/a 53.7n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50413173
PNG
(CHEMBL513056)
Show SMILES Cc1nc[nH]c1CSCC(=O)NC(N)=NCCCc1cnc[nH]1 |w:14.15|
Show InChI InChI=1S/C14H21N7OS/c1-10-12(20-9-18-10)6-23-7-13(22)21-14(15)17-4-2-3-11-5-16-8-19-11/h5,8-9H,2-4,6-7H2,1H3,(H,16,19)(H,18,20)(H3,15,17,21,22)
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n/an/an/a 4.27E+3n/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM86738
PNG
(UR-AK46)
Show SMILES NC(NC(=O)C1CCCCC1)=NCCCc1cnc[nH]1 |w:11.12|
Show InChI InChI=1S/C14H23N5O/c15-14(17-8-4-7-12-9-16-10-18-12)19-13(20)11-5-2-1-3-6-11/h9-11H,1-8H2,(H,16,18)(H3,15,17,19,20)
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n/an/an/a 5.13E+3n/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50275884
PNG
(CHEMBL471413 | N1-(3,3-Diphenylpropanoyl)-N2-[3-(1...)
Show SMILES NC(NC(=O)CC(c1ccccc1)c1ccccc1)=NCCCc1cnc[nH]1 |w:19.21|
Show InChI InChI=1S/C22H25N5O/c23-22(25-13-7-12-19-15-24-16-26-19)27-21(28)14-20(17-8-3-1-4-9-17)18-10-5-2-6-11-18/h1-6,8-11,15-16,20H,7,12-14H2,(H,24,26)(H3,23,25,27,28)
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n/an/an/an/a 28.2n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM22884
PNG
(2-[3-(1H-imidazol-5-yl)propyl]-1-(2-{[(5-methyl-1H...)
Show SMILES Cc1nc[nH]c1CSCCN=C(N)NCCCc1cnc[nH]1 |w:10.10|
Show InChI InChI=1S/C14H23N7S/c1-11-13(21-10-19-11)8-22-6-5-18-14(15)17-4-2-3-12-7-16-9-20-12/h7,9-10H,2-6,8H2,1H3,(H,16,20)(H,19,21)(H3,15,17,18)
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n/an/an/an/a 19.9n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM7966
PNG
(2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...)
Show SMILES NCCc1cnc[nH]1
Show InChI InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
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n/an/an/an/a 25.1n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Activity at human recombinant histamine H3 receptor expressed in Sf9 cells coexpressing Galphai, G-beta-1-gamma-2 and RGS4 by steady-state GTPase act...


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50276073
PNG
(CHEMBL502339 | N1-[3-(1H-Imidazol-4-yl)propyl]-N2-...)
Show SMILES CC(CC(=O)NC(N)=NCCCc1cnc[nH]1)c1cccs1 |w:8.8|
Show InChI InChI=1S/C15H21N5OS/c1-11(13-5-3-7-22-13)8-14(21)20-15(16)18-6-2-4-12-9-17-10-19-12/h3,5,7,9-11H,2,4,6,8H2,1H3,(H,17,19)(H3,16,18,20,21)
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n/an/an/an/a 1.64n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Activity at human recombinant histamine H3 receptor expressed in Sf9 cells coexpressing Galphai, G-beta-1-gamma-2 and RGS4 by steady-state GTPase act...


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50275884
PNG
(CHEMBL471413 | N1-(3,3-Diphenylpropanoyl)-N2-[3-(1...)
Show SMILES NC(NC(=O)CC(c1ccccc1)c1ccccc1)=NCCCc1cnc[nH]1 |w:19.21|
Show InChI InChI=1S/C22H25N5O/c23-22(25-13-7-12-19-15-24-16-26-19)27-21(28)14-20(17-8-3-1-4-9-17)18-10-5-2-6-11-18/h1-6,8-11,15-16,20H,7,12-14H2,(H,24,26)(H3,23,25,27,28)
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n/an/an/an/a 8.60n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Activity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-s...


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM86735
PNG
(UR-AK26)
Show SMILES NC(NC(=O)Cc1ccccc1)=NCCCc1cnc[nH]1 |w:12.13|
Show InChI InChI=1S/C15H19N5O/c16-15(18-8-4-7-13-10-17-11-19-13)20-14(21)9-12-5-2-1-3-6-12/h1-3,5-6,10-11H,4,7-9H2,(H,17,19)(H3,16,18,20,21)
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n/an/an/an/a 182n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM22884
PNG
(2-[3-(1H-imidazol-5-yl)propyl]-1-(2-{[(5-methyl-1H...)
Show SMILES Cc1nc[nH]c1CSCCN=C(N)NCCCc1cnc[nH]1 |w:10.10|
Show InChI InChI=1S/C14H23N7S/c1-11-13(21-10-19-11)8-22-6-5-18-14(15)17-4-2-3-12-7-16-9-20-12/h7,9-10H,2-6,8H2,1H3,(H,16,20)(H,19,21)(H3,15,17,18)
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n/an/an/a 3.39E+3n/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM86735
PNG
(UR-AK26)
Show SMILES NC(NC(=O)Cc1ccccc1)=NCCCc1cnc[nH]1 |w:12.13|
Show InChI InChI=1S/C15H19N5O/c16-15(18-8-4-7-13-10-17-11-19-13)20-14(21)9-12-5-2-1-3-6-12/h1-3,5-6,10-11H,4,7-9H2,(H,17,19)(H3,16,18,20,21)
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n/an/an/a 575n/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50413171
PNG
(CHEMBL472273)
Show SMILES NC(NC(=O)CC(c1ccc(F)cc1)c1ccccn1)=NCCCc1cnc[nH]1 |w:20.22|
Show InChI InChI=1S/C21H23FN6O/c22-16-8-6-15(7-9-16)18(19-5-1-2-10-25-19)12-20(29)28-21(23)26-11-3-4-17-13-24-14-27-17/h1-2,5-10,13-14,18H,3-4,11-12H2,(H,24,27)(H3,23,26,28,29)
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n/an/an/a 3.72E+3n/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50413170
PNG
(CHEMBL472272)
Show SMILES NC(NC(=O)CC(c1ccccc1)c1ccccn1)=NCCCc1cnc[nH]1 |w:19.21|
Show InChI InChI=1S/C21H24N6O/c22-21(25-12-6-9-17-14-23-15-26-17)27-20(28)13-18(16-7-2-1-3-8-16)19-10-4-5-11-24-19/h1-5,7-8,10-11,14-15,18H,6,9,12-13H2,(H,23,26)(H3,22,25,27,28)
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n/an/an/a 1.12E+4n/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM86744
PNG
(UR-AK62)
Show SMILES NC(NC(=O)CC1CCCCC1)=NCCCc1cnc[nH]1 |w:12.13|
Show InChI InChI=1S/C15H25N5O/c16-15(18-8-4-7-13-10-17-11-19-13)20-14(21)9-12-5-2-1-3-6-12/h10-12H,1-9H2,(H,17,19)(H3,16,18,20,21)
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n/an/an/a 2.45E+3n/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50413181
PNG
(CHEMBL499301)
Show SMILES NC(NC(=O)CC(c1ccccc1)c1ccccc1)=NCCc1cnc[nH]1 |w:19.21|
Show InChI InChI=1S/C21H23N5O/c22-21(24-12-11-18-14-23-15-25-18)26-20(27)13-19(16-7-3-1-4-8-16)17-9-5-2-6-10-17/h1-10,14-15,19H,11-13H2,(H,23,25)(H3,22,24,26,27)
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n/an/an/a 9.77E+3n/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM86745
PNG
(UR-AK51)
Show SMILES NC(NC(=O)CCc1ccccc1)=NCCCc1cnc[nH]1 |w:13.14|
Show InChI InChI=1S/C16H21N5O/c17-16(19-10-4-7-14-11-18-12-20-14)21-15(22)9-8-13-5-2-1-3-6-13/h1-3,5-6,11-12H,4,7-10H2,(H,18,20)(H3,17,19,21,22)
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n/an/an/a 2.14E+3n/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50276073
PNG
(CHEMBL502339 | N1-[3-(1H-Imidazol-4-yl)propyl]-N2-...)
Show SMILES CC(CC(=O)NC(N)=NCCCc1cnc[nH]1)c1cccs1 |w:8.8|
Show InChI InChI=1S/C15H21N5OS/c1-11(13-5-3-7-22-13)8-14(21)20-15(16)18-6-2-4-12-9-17-10-19-12/h3,5,7,9-11H,2,4,6,8H2,1H3,(H,17,19)(H3,16,18,20,21)
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n/an/an/an/a 109n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Activity at human recombinant histamine H2 receptor-Gsalpha fusion protein expressed in Sf9 cells by steady-state GTPase activity assay


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM86171
PNG
(ARPROMIDINE | Arpromidine | CAS_65895 | NSC_65895)
Show SMILES NC(NCCCc1cnc[nH]1)=NCCC(c1ccc(F)cc1)c1ccccn1 |w:11.12|
Show InChI InChI=1S/C21H25FN6/c22-17-8-6-16(7-9-17)19(20-5-1-2-11-25-20)10-13-27-21(23)26-12-3-4-18-14-24-15-28-18/h1-2,5-9,11,14-15,19H,3-4,10,12-13H2,(H,24,28)(H3,23,26,27)
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n/an/an/a 22.4n/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM86737
PNG
(UR-AK22)
Show SMILES NC(NC(=O)CCCCc1ccccc1)=NCCCc1cnc[nH]1 |w:15.16|
Show InChI InChI=1S/C18H25N5O/c19-18(21-12-6-10-16-13-20-14-22-16)23-17(24)11-5-4-9-15-7-2-1-3-8-15/h1-3,7-8,13-14H,4-6,9-12H2,(H,20,22)(H3,19,21,23,24)
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n/an/an/a 562n/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50377986
PNG
(CHEMBL483406 | UR-AK24)
Show SMILES CC(CC(=O)NC(N)=NCCCc1cnc[nH]1)c1ccccc1 |w:8.8|
Show InChI InChI=1S/C17H23N5O/c1-13(14-6-3-2-4-7-14)10-16(23)22-17(18)20-9-5-8-15-11-19-12-21-15/h2-4,6-7,11-13H,5,8-10H2,1H3,(H,19,21)(H3,18,20,22,23)
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n/an/an/an/a 15.8n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM86738
PNG
(UR-AK46)
Show SMILES NC(NC(=O)C1CCCCC1)=NCCCc1cnc[nH]1 |w:11.12|
Show InChI InChI=1S/C14H23N5O/c15-14(17-8-4-7-12-9-16-10-18-12)19-13(20)11-5-2-1-3-6-11/h9-11H,1-8H2,(H,16,18)(H3,15,17,19,20)
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n/an/an/an/a 47.9n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50413174
PNG
(CHEMBL513755)
Show SMILES NC(NC(=O)CC(c1nccs1)c1ccc(F)c(F)c1)=NCCCc1cnc[nH]1 |w:20.22|
Show InChI InChI=1S/C19H20F2N6OS/c20-15-4-3-12(8-16(15)21)14(18-24-6-7-29-18)9-17(28)27-19(22)25-5-1-2-13-10-23-11-26-13/h3-4,6-8,10-11,14H,1-2,5,9H2,(H,23,26)(H3,22,25,27,28)
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n/an/an/a 4.68E+3n/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50413173
PNG
(CHEMBL513056)
Show SMILES Cc1nc[nH]c1CSCC(=O)NC(N)=NCCCc1cnc[nH]1 |w:14.15|
Show InChI InChI=1S/C14H21N7OS/c1-10-12(20-9-18-10)6-23-7-13(22)21-14(15)17-4-2-3-11-5-16-8-19-11/h5,8-9H,2-4,6-7H2,1H3,(H,16,19)(H,18,20)(H3,15,17,21,22)
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n/an/an/an/a 30.9n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50413178
PNG
(CHEMBL469749)
Show SMILES NC(NC(=O)CC(c1ccccc1)c1ccc(F)cc1)=NCCCc1cnc[nH]1 |w:20.22|
Show InChI InChI=1S/C22H24FN5O/c23-18-10-8-17(9-11-18)20(16-5-2-1-3-6-16)13-21(29)28-22(24)26-12-4-7-19-14-25-15-27-19/h1-3,5-6,8-11,14-15,20H,4,7,12-13H2,(H,25,27)(H3,24,26,28,29)
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n/an/an/an/a 55.0n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM86740
PNG
(UR-AK24 | UR-AK57)
Show SMILES CC(CC(=O)NC(N)=NCCCc1cnc[nH]1)C1CCCCC1 |w:8.8|
Show InChI InChI=1S/C17H29N5O/c1-13(14-6-3-2-4-7-14)10-16(23)22-17(18)20-9-5-8-15-11-19-12-21-15/h11-14H,2-10H2,1H3,(H,19,21)(H3,18,20,22,23)
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n/an/an/a 2.19E+3n/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM86171
PNG
(ARPROMIDINE | Arpromidine | CAS_65895 | NSC_65895)
Show SMILES NC(NCCCc1cnc[nH]1)=NCCC(c1ccc(F)cc1)c1ccccn1 |w:11.12|
Show InChI InChI=1S/C21H25FN6/c22-17-8-6-16(7-9-17)19(20-5-1-2-11-25-20)10-13-27-21(23)26-12-3-4-18-14-24-15-28-18/h1-2,5-9,11,14-15,19H,3-4,10,12-13H2,(H,24,28)(H3,23,26,27)
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n/an/an/an/a 9.77n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50413180
PNG
(CHEMBL472271)
Show SMILES NC(NC(=O)CC(c1ccc(Br)cc1)c1ccc(Br)cc1)=NCCCc1cnc[nH]1 |w:21.23|
Show InChI InChI=1S/C22H23Br2N5O/c23-17-7-3-15(4-8-17)20(16-5-9-18(24)10-6-16)12-21(30)29-22(25)27-11-1-2-19-13-26-14-28-19/h3-10,13-14,20H,1-2,11-12H2,(H,26,28)(H3,25,27,29,30)
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n/an/an/an/a 776n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50276073
PNG
(CHEMBL502339 | N1-[3-(1H-Imidazol-4-yl)propyl]-N2-...)
Show SMILES CC(CC(=O)NC(N)=NCCCc1cnc[nH]1)c1cccs1 |w:8.8|
Show InChI InChI=1S/C15H21N5OS/c1-11(13-5-3-7-22-13)8-14(21)20-15(16)18-6-2-4-12-9-17-10-19-12/h3,5,7,9-11H,2,4,6,8H2,1H3,(H,17,19)(H3,16,18,20,21)
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n/an/an/an/a 38.0n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM86747
PNG
(UR-AK67)
Show SMILES NC(NC(=O)CCCc1ccccc1)=NCCCc1cnc[nH]1 |w:14.15|
Show InChI InChI=1S/C17H23N5O/c18-17(20-11-5-9-15-12-19-13-21-15)22-16(23)10-4-8-14-6-2-1-3-7-14/h1-3,6-7,12-13H,4-5,8-11H2,(H,19,21)(H3,18,20,22,23)
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n/an/an/an/a 56.2n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM86741
PNG
(UR-AK59)
Show SMILES CC(C1CCCCC1)C(=O)NC(N)=NCCCc1cnc[nH]1 |w:13.14|
Show InChI InChI=1S/C16H27N5O/c1-12(13-6-3-2-4-7-13)15(22)21-16(17)19-9-5-8-14-10-18-11-20-14/h10-13H,2-9H2,1H3,(H,18,20)(H3,17,19,21,22)
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n/an/an/an/a 138n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50275884
PNG
(CHEMBL471413 | N1-(3,3-Diphenylpropanoyl)-N2-[3-(1...)
Show SMILES NC(NC(=O)CC(c1ccccc1)c1ccccc1)=NCCCc1cnc[nH]1 |w:19.21|
Show InChI InChI=1S/C22H25N5O/c23-22(25-13-7-12-19-15-24-16-26-19)27-21(28)14-20(17-8-3-1-4-9-17)18-10-5-2-6-11-18/h1-6,8-11,15-16,20H,7,12-14H2,(H,24,26)(H3,23,25,27,28)
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n/an/an/an/a 78n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Activity at human recombinant histamine H2 receptor-Gsalpha fusion protein expressed in Sf9 cells by steady-state GTPase activity assay


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50377986
PNG
(CHEMBL483406 | UR-AK24)
Show SMILES CC(CC(=O)NC(N)=NCCCc1cnc[nH]1)c1ccccc1 |w:8.8|
Show InChI InChI=1S/C17H23N5O/c1-13(14-6-3-2-4-7-14)10-16(23)22-17(18)20-9-5-8-15-11-19-12-21-15/h2-4,6-7,11-13H,5,8-10H2,1H3,(H,19,21)(H3,18,20,22,23)
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n/an/an/an/a 12n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Activity at guinea pig recombinant histamine H2 receptor-Gsalpha fusion protein expressed in Sf9 cells by steady-state GTPase activity assay


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50413170
PNG
(CHEMBL472272)
Show SMILES NC(NC(=O)CC(c1ccccc1)c1ccccn1)=NCCCc1cnc[nH]1 |w:19.21|
Show InChI InChI=1S/C21H24N6O/c22-21(25-12-6-9-17-14-23-15-26-17)27-20(28)13-18(16-7-2-1-3-8-16)19-10-4-5-11-24-19/h1-5,7-8,10-11,14-15,18H,6,9,12-13H2,(H,23,26)(H3,22,25,27,28)
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n/an/an/an/a 51.3n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50413179
PNG
(CHEMBL472054)
Show SMILES NC(NC(=O)CC(c1ccc(Cl)cc1)c1ccc(Cl)cc1)=NCCCc1cnc[nH]1 |w:21.23|
Show InChI InChI=1S/C22H23Cl2N5O/c23-17-7-3-15(4-8-17)20(16-5-9-18(24)10-6-16)12-21(30)29-22(25)27-11-1-2-19-13-26-14-28-19/h3-10,13-14,20H,1-2,11-12H2,(H,26,28)(H3,25,27,29,30)
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n/an/an/an/a 309n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM86745
PNG
(UR-AK51)
Show SMILES NC(NC(=O)CCc1ccccc1)=NCCCc1cnc[nH]1 |w:13.14|
Show InChI InChI=1S/C16H21N5O/c17-16(19-10-4-7-14-11-18-12-20-14)21-15(22)9-8-13-5-2-1-3-6-13/h1-3,5-6,11-12H,4,7-10H2,(H,18,20)(H3,17,19,21,22)
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n/an/an/an/a 166n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50413171
PNG
(CHEMBL472273)
Show SMILES NC(NC(=O)CC(c1ccc(F)cc1)c1ccccn1)=NCCCc1cnc[nH]1 |w:20.22|
Show InChI InChI=1S/C21H23FN6O/c22-16-8-6-15(7-9-16)18(19-5-1-2-10-25-19)12-20(29)28-21(23)26-11-3-4-17-13-24-14-27-17/h1-2,5-10,13-14,18H,3-4,11-12H2,(H,24,27)(H3,23,26,28,29)
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n/an/an/an/a 33.9n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM86736
PNG
(UR-AK68)
Show SMILES CC(C(=O)NC(N)=NCCCc1cnc[nH]1)c1ccccc1 |w:7.7|
Show InChI InChI=1S/C16H21N5O/c1-12(13-6-3-2-4-7-13)15(22)21-16(17)19-9-5-8-14-10-18-11-20-14/h2-4,6-7,10-12H,5,8-9H2,1H3,(H,18,20)(H3,17,19,21,22)
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n/an/an/a>1.00E+4n/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity


J Med Chem 51: 7193-204 (2009)


Article DOI: 10.1021/jm800841w
BindingDB Entry DOI: 10.7270/Q2RN38T6
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%