332 articles for thisTarget

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The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
28279845	54	Design, synthesis and evaluation of novel ferulic acid-O-alkylamine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.	Nanyang Normal University
28279561	26	Green synthesis of novel spiro-indenoquinoxaline derivatives and their cholinesterases inhibition activity.	Persian Gulf University
27744187	42	Design, synthesis and biological evaluation of bambuterol analogues as novel inhibitors of butyrylcholinesterase.	South China University of Technology
28189905	35	New tacrine-derived AChE/BuChE inhibitors: Synthesis and biological evaluation of 5-amino-2-phenyl-4H-pyrano[2,3-b]quinoline-3-carboxylates.	University of Mazandaran
27876467	9	A review on tacrine-based scaffolds as multi-target drugs (MTDLs) for Alzheimer's disease.	Tehran University of Medical Sciences
27951490	72	2,4-Disubstituted quinazolines as amyloid-ß aggregation inhibitors with dual cholinesterase inhibition and antioxidant properties: Development and structure-activity relationship (SAR) studies.	University of Waterloo
27936444	93	Amino derivatives of platanic acid act as selective and potent inhibitors of butyrylcholinesterase.	Martin-Luther-University Halle-Wittenberg
27951489	78	Novel ferulic amide derivatives with tertiary amine side chain as acetylcholinesterase and butyrylcholinesterase inhibitors: The influence of carbon spacer length, alkylamine and aromatic group.	Hu'Nan University
27688184	29	New azepino[4,3-b]indole derivatives as nanomolar selective inhibitors of human butyrylcholinesterase showing protective effects against NMDA-induced neurotoxicity.	University of Bari&Quot;A. Moro&Quot
27560283	58	Novel multi-target-directed ligands for Alzheimer's disease: Combining cholinesterase inhibitors and 5-HT	Jagiellonian University Collegium Medicum
27908752	55	N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer's agents.	University of Ljubljana
27923619	13	Synthesis and application ofß-carbolines as novel multi-functional anti-Alzheimer's disease agents.	University of Massachusetts Boston
27484515	61	Synthesis and structure-activity relationship study of tacrine-based pyrano[2,3-c]pyrazoles targeting AChE/BuChE and 15-LOX.	Tehran University of Medical Sciences
27484514	107	Rational modification of donepezil as multifunctional acetylcholinesterase inhibitors for the treatment of Alzheimer's disease.	China Pharmaceutical University
27856236	19	Design, synthesis, biological evaluation, and molecular modeling studies of chalcone-rivastigmine hybrids as cholinesterase inhibitors.	South China University of Technology
27780618	7	Synthesis, structure-activity relationship and molecular docking of 3-oxoaurones and 3-thioaurones as acetylcholinesterase and butyrylcholinesterase inhibitors.	University of Gujrat
26471320	50	Donepezil-like multifunctional agents: Design, synthesis, molecular modeling and biological evaluation.	Okayama University
27267007	58	New cinnamic - N-benzylpiperidine and cinnamic - N,N-dibenzyl(N-methyl)amine hybrids as Alzheimer-directed multitarget drugs with antioxidant, cholinergic, neuroprotective and neurogenic properties.	Instituto De Qu£Mica M£Dica
27392529	32	Novel series of tacrine-tianeptine hybrids: Synthesis, cholinesterase inhibitory activity, S100B secretion and a molecular modeling approach.	Universidade Federal Do Rio Grande Do Sul
27377327	22	Novel potent pyridoxine-based inhibitors of AChE and BChE, structural analogs of pyridostigmine, with improved in vivo safety profile.	Kazan (Volga Region) Federal University
27309570	102	Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer's Disease Agents.	Alma Mater Studiorum-University of Bologna
27492195	14	Cholinesterase inhibitory activity of isoquinoline alkaloids from three Cryptocarya species (Lauraceae).	University of Malaya
27460699	76	Synthesis and evaluation of multi-target-directed ligands for the treatment of Alzheimer's disease based on the fusion of donepezil and melatonin.	China Pharmaceutical University
26886849	72	Discovery of Highly Selective and Nanomolar Carbamate-Based Butyrylcholinesterase Inhibitors by Rational Investigation into Their Inhibition Mode.	Universit£T W£Rzburg
26945113	9	Amyloid cascade in Alzheimer's disease: Recent advances in medicinal chemistry.	University of Waterloo
26879857	50	Application of PEG-400 as a green biodegradable polymeric medium for the catalyst-free synthesis of spiro-dihydropyridines and their use as acetyl and butyrylcholinesterase inhibitors.	Persian Gulf University
26917219	63	Design, synthesis and biological evaluation of novel donepezil-coumarin hybrids as multi-target agents for the treatment of Alzheimer's disease.	China Pharmaceutical University
26632651	70	Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography.	China Pharmaceutical University
26503905	51	Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity.	University Hospital Hradec Kralove
26363866	39	New multifunctional melatonin-derived benzylpyridinium bromides with potent cholinergic, antioxidant, and neuroprotective properties as innovative drugs for Alzheimer's disease.	1St Affiliated Hospital of Guangxi Medical University
26189031	52	Synthesis of novel triazoles and a tetrazole of escitalopram as cholinesterase inhibitors.	University of The Punjab
25260958	46	Design, synthesis and pharmacological evaluation of chalcone derivatives as acetylcholinesterase inhibitors.	Hu'Nan University
26116179	5	Structure-based development of nitroxoline derivatives as potential multifunctional anti-Alzheimer agents.	University of Ljubljana
26107513	172	Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases.	Universit£
26003344	48	Isolation of cholinesterase andß-secretase 1 inhibiting compounds from Lycopodiella cernua.	Catholic University of Daegu
25812965	80	Multi-target tacrine-coumarin hybrids: cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease.	China Pharmaceutical University
25656088	32	Multifunctional tacrine-trolox hybrids for the treatment of Alzheimer's disease with cholinergic, antioxidant, neuroprotective and hepatoprotective properties.	China Pharmaceutical University
25418133	51	N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor.	Laboratorio De Quimica Medica (Iqog, Csic)
25813159	3	New septanoside and 20-hydroxyecdysone septanoside derivative from Atriplex portulacoides roots with preliminary biological activities.	University of Monastir
25597004	18	Iminosugars as a new class of cholinesterase inhibitors.	University of Strasburg
25089370	40	Synthesis and biological evaluation of novel tacrine derivatives and tacrine-coumarin hybrids as cholinesterase inhibitors.	P. J. Safarik University
25088549	47	Syntheses of coumarin-tacrine hybrids as dual-site acetylcholinesterase inhibitors and their activity against butylcholinesterase, Aß aggregation, andß-secretase.	Central China Normal University
25016233	14	Tetrahydrobenzo[h][1,6]naphthyridine-6-chlorotacrine hybrids as a new family of anti-Alzheimer agents targetingß-amyloid, tau, and cholinesterase pathologies.	Universitat De Barcelona
24934993	6	Coumarin hybrids as novel therapeutic agents.	Punjabi University
25537270	6	Sulfonamides as multifunctional agents for Alzheimer's disease.	University of Massachusetts Boston
25259726	44	Multitarget drug design strategy: quinone-tacrine hybrids designed to block amyloid-ß aggregation and to exert anticholinesterase and antioxidant effects.	Alma Mater Studiorum-University of Bologna
25257911	33	Active compounds from a diverse library of triazolothiadiazole and triazolothiadiazine scaffolds: synthesis, crystal structure determination, cytotoxicity, cholinesterase inhibitory activity, and binding mode analysis.	Quaid-I-Azam University
25226236	19	Discovery, biological evaluation, and crystal structure of a novel nanomolar selective butyrylcholinesterase inhibitor.	University of Ljubljana
25189690	94	Design, synthesis and biological evaluation of novel 6H-benzo[c]chromen-6-one, and 7,8,9,10-tetrahydro-benzo[c]chromen-6-one derivatives as potential cholinesterase inhibitors.	Eastern Mediterranean University
25156301	8	Shogaol-huprine hybrids: dual antioxidant and anticholinesterase agents withß-amyloid and tau anti-aggregating properties.	Universitat De Barcelona
24980117	62	Synthesis ofa,ß-unsaturated carbonyl based compounds as acetylcholinesterase and butyrylcholinesterase inhibitors: characterization, molecular modeling, QSAR studies and effect against amyloidß-induced cytotoxicity.	Universiti Kebangsaan Malaysia
24780600	53	Dual inhibition of thea-glucosidase and butyrylcholinesterase studied by molecular field topology analysis.	University of Florida
24726809	72	Design, synthesis and biological evaluation of benzylisoquinoline derivatives as multifunctional agents against Alzheimer's disease.	China Pharmaceutical University
24568372	40	Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents.	Universitat De Barcelona
24681981	53	Synthesis, crystal structure and biological evaluation of some novel 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles and 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines.	Quaid-I-Azam University
24675179	26	Synthesis, cytotoxicity and molecular modelling studies of new phenylcinnamide derivatives as potent inhibitors of cholinesterases.	Quaid-I-Azam University
24900626	15	Multifunctional cholinesterase and amyloid Beta fibrillization modulators. Synthesis and biological investigation.	University of Siena
24220173	37	Preparation, in vitro evaluation and molecular modelling of pyridinium-quinolinium/isoquinolinium non-symmetrical bisquaternary cholinesterase inhibitors.	Charles University In Prague
23810675	42	Synthesis, evaluation and molecular dynamics study of some new 4-aminopyridine semicarbazones as an antiamnesic and cognition enhancing agents.	Banaras Hindu University
23422935	29	Synthesis of tacrine-lophine hybrids via one-pot four component reaction and biological evaluation as acetyl- and butyrylcholinesterase inhibitors.	Universidade Federal Do Rio Grande Do Sul
23199476	36	Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase.	Universit£
17276075	4	Structure-activity relationships of methoctramine-related polyamines as muscarinic antagonist: effect of replacing the inner polymethylene chain with cyclic moieties.	Universit£
11141093	20	Hexahydrochromeno[4,3-b]pyrrole derivatives as acetylcholinesterase inhibitors.	University of Bologna
22795665	24	Synthesis, biological assessment, and molecular modeling of racemic 7-aryl-9,10,11,12-tetrahydro-7H-benzo[7,8]chromeno[2,3-b]quinolin-8-amines as potential drugs for the treatment of Alzheimer's disease.	Universit£
23062825	37	Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.	Abo Akademi University
23164658	78	2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents.	University of Bologna
23041347	33	Design, synthesis, and bioevaluation of benzamides: novel acetylcholinesterase inhibitors with multi-functions on butylcholinesterase, Aß aggregation, andß-secretase.	Central China Normal University
22339166	14	Radiolabeled cyclosaligenyl monophosphates of 5-iodo-2'-deoxyuridine, 5-iodo-3'-fluoro-2',3'-dideoxyuridine, and 3'-fluorothymidine for molecular radiotherapy of cancer: synthesis and biological evaluation.	University of Nebraska Medical Center
23078965	19	Pyridonepezils, new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease: synthesis, biological assessment, and molecular modeling.	Instituto De Qu£Mica Org£Nica General (Csic)
22818849	36	Synthesis, design and biological evaluation of novel highly potent tacrine congeners for the treatment of Alzheimer's disease.	P. J. Safarik University
24900454	43	The First Dual ChE/FAAH Inhibitors: New Perspectives for Alzheimer's Disease?	TBA
22503231	66	Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine.	Laboratorio De Radicales Libres Y Qu�Mica Computacional (Iqog, Csic)
22243648	112	New tacrine-4-oxo-4H-chromene hybrids as multifunctional agents for the treatment of Alzheimer's disease, with cholinergic, antioxidant, andß-amyloid-reducing properties.	Instituto De Qu£Mica M£Dica
22185619	50	Huprine-tacrine heterodimers as anti-amyloidogenic compounds of potential interest against Alzheimer's and prion diseases.	Universitat De Barcelona
21144749	55	Preparation, in vitro screening and molecular modelling of symmetrical 4-tert-butylpyridinium cholinesterase inhibitors--analogues of SAD-128.	University of Defence
20627738	32	Long-acting anticholinesterases for myasthenia gravis: synthesis and activities of quaternary phenylcarbamates of neostigmine, pyridostigmine and physostigmine.	National Institute On Aging
20067290	24	Isosorbide-2-benzyl carbamate-5-salicylate, a peripheral anionic site binding subnanomolar selective butyrylcholinesterase inhibitor.	Trinity College
19879672	16	Structural aspects of flavonoids as inhibitors of human butyrylcholinesterase.	Institute For Medical Research and Occupational Health
19473849	33	Synthesis and structure-activity relationship of Huprine derivatives as human acetylcholinesterase inhibitors.	Cobra
18954037	40	Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 4. Further investigation on the inner spacer.	University of Bologna
18640842	45	New tacrine-dihydropyridine hybrids that inhibit acetylcholinesterase, calcium entry, and exhibit neuroprotection properties.	Laboratorio De Radicales Libres (Iqog, Csic)
18517184	47	Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.	Laboratori De Qu�Mica Farmac�Utica (Unitat Associada Al Csic)
18479118	114	Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.	Universit£
18232655	32	Synthesis and biological evaluation of NO-donor-tacrine hybrids as hepatoprotective anti-Alzheimer drug candidates.	TBA
18181565	71	Multi-target-directed ligands to combat neurodegenerative diseases.	University of Bologna
18023348	16	4-Aminopyridine derivatives with anticholinesterase and antiamnesic activity.	Sapienza University of Rome
17850125	66	Novel class of quinone-bearing polyamines as multi-target-directed ligands to combat Alzheimer's disease.	University of Bologna
17328534	16	Bis-cycloSal-d4T-monophosphates: drugs that deliver two molecules of bioactive nucleotides.	University of Hamburg
17154513	56	Binding of 13-amidohuprines to acetylcholinesterase: exploring the ligand-induced conformational change of the gly117-gly118 peptide bond in the oxyanion hole.	Universitat De Barcelona
15715468	44	Novel anticholinesterases based on the molecular skeletons of furobenzofuran and methanobenzodioxepine.	National Institute On Aging
15887964	47	Further studies on the interaction of the 5-hydroxytryptamine3 (5-HT3) receptor with arylpiperazine ligands. development of a new 5-HT3 receptor ligand showing potent acetylcholinesterase inhibitory properties.	Universit£
15633997	18	Propidium-based polyamine ligands as potent inhibitors of acetylcholinesterase and acetylcholinesterase-induced amyloid-beta aggregation.	University of Bologna
15139762	133	Interaction of cycloSal-pronucleotides with cholinesterases from different origins. A structure-activity relationship.	University of Hamburg
12502352	28	Specific targeting of acetylcholinesterase and butyrylcholinesterase recognition sites. Rational design of novel, selective, and highly potent cholinesterase inhibitors.	Universit£
11741490	18	Synthesis, in vitro pharmacology, and molecular modeling of syn-huprines as acetylcholinesterase inhibitors.	Universitat De Barcelona
11495583	62	Design, synthesis, and structure-activity relationships of a series of 3-[2-(1-benzylpiperidin-4-yl)ethylamino]pyridazine derivatives as acetylcholinesterase inhibitors.	Universit£
11101357	84	New tacrine-huperzine A hybrids (huprines): highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease.	Universitat De Barcelona
10052979	45	Aminopyridazines as acetylcholinesterase inhibitors.	Universit£
10464010	40	Synthesis, in vitro pharmacology, and molecular modeling of very potent tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease.	Universitat De Barcelona
9784091	25	Acetylcholinesterase noncovalent inhibitors based on a polyamine backbone for potential use against Alzheimer's disease.	University of Bologna
7707311	18	Design and synthesis of 1-heteroaryl-3-(1-benzyl-4-piperidinyl)propan-1-one derivatives as potent, selective acetylcholinesterase inhibitors.	Pfizer
1552502	74	Synthesis and cholinergic properties of bis[[(dimethylamino)methyl]furanyl] analogues of ranitidine.	University of South Carolina
2738887	22	Binary antidotes for organophosphate poisoning: aprophen analogues that are both antimuscarinics and carbamates.	Institute of Research
21438612	4	Amidine-oximes: reactivators for organophosphate exposure.	Human Biomolecular Research Institute
22206546	42	Nonquaternary reactivators for organophosphate-inhibited cholinesterases.	Human Biomolecular Research Institute
22257528	5	A review on coumarins as acetylcholinesterase inhibitors for Alzheimer's disease.	Punjabi University
22054058	22	Synthesis of monomeric derivatives to probe memoquin's bivalent interactions.	University of Bologna
22023459	42	Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.	Universitat Aut£Noma De Barcelona
22000936	33	Synthesis and biological assessment of diversely substituted furo[2,3-b]quinolin-4-amine and pyrrolo[2,3-b]quinolin-4-amine derivatives, as novel tacrine analogues.	University of Lisbon
21924611	38	Selective cholinesterase inhibition by lanostane triterpenes from fruiting bodies of Ganoderma lucidum.	Chungnam National University
21920739	14	Synthesis and in vitro evaluation of 7-methoxy-N-(pent-4-enyl)-1,2,3,4-tetrahydroacridin-9-amine-new tacrine derivate with cholinergic properties.	Charles University In Prague
21924801	20	Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease.	University of Bologna
21798635	32	Multi-target strategy to address Alzheimer's disease: design, synthesis and biological evaluation of new tacrine-based dimers.	Institut F£R Molekulare Physiologie
21733699	121	Requirements for mammalian carboxylesterase inhibition by substituted ethane-1,2-diones.	St. Jude Children'S Research Hospital
21570751	8	Synthesis, biological activity and HPLC validation of 1,2,3,4-tetrahydroacridine derivatives as acetylcholinesterase inhibitors.	Medical University
21435752	76	New potent human acetylcholinesterase inhibitors in the tetracyclic triterpene series with inhibitory potency on amyloid β aggregation.	Cnrs
19443217	60	Synthesis and biological evaluation of novel gamma-carboline analogues of Dimebon as potent 5-HT6 receptor antagonists.	Chemical Diversity Research Institute
19423342	10	Novel carbamate cholinesterase inhibitors that release biologically active amines following enzyme inhibition.	Sention
21397996	36	Benzophenone-based derivatives: a novel series of potent and selective dual inhibitors of acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.	University of Bologna
21417225	116	Homodimeric bis-quaternary heterocyclic ammonium salts as potent acetyl- and butyrylcholinesterase inhibitors: a systematic investigation of the influence of linker and cationic heads over affinity and selectivity.	Universidad De Granada
21236667	16	Multitargeted drugs discovery: balancing anti-amyloid and anticholinesterase capacity in a single chemical entity.	Department of Pharmaceutical Sciences-Alma Mater Studiorum-Bologna University
21216144	13	(+)-Arisugacin A--computational evidence of a dual binding site covalent inhibitor of acetylcholinesterase.	Alchemical Research
21397501	54	Preparation, in vitro screening and molecular modelling of symmetrical bis-quinolinium cholinesterase inhibitors--implications for early myasthenia gravis treatment.	Charles University
21236521	58	Preparation and in vitro screening of symmetrical bis-isoquinolinium cholinesterase inhibitors bearing various connecting linkage--implications for early Myasthenia gravis treatment.	University of Defence
21105730	30	Structure-activity relationships of substituted 1-pyridyl-2-phenyl-1,2-ethanediones: potent, selective carboxylesterase inhibitors.	St. Jude Children'S Research Hospital
20801550	9	Synthesis, characterization, oxidative degradation, antibacterial activity and acetylcholinesterase/butyrylcholinesterase inhibitory effects of some new phosphorus(V) hydrazides.	Tarbiat Modares University
20817518	23	Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease.	Charles University
20545360	38	Novel tacrine-8-hydroxyquinoline hybrids as multifunctional agents for the treatment of Alzheimer's disease, with neuroprotective, cholinergic, antioxidant, and copper-complexing properties.	Instituto De Quimica Medica
20138518	40	Preparation and in vitro screening of symmetrical bispyridinium cholinesterase inhibitors bearing different connecting linkage-initial study for Myasthenia gravis implications.	Military Health Sciences
19856923	40	Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease.	Instituto De Quimica Medica (Csic)
20181484	46	Differential binding of phenothiazine urea derivatives to wild-type human cholinesterases and butyrylcholinesterase mutants.	Dalhousie University
20171894	49	Targeting Alzheimer's disease: Novel indanone hybrids bearing a pharmacophoric fragment of AP2238.	University of Bologna
20093035	9	Isosorbide-based cholinesterase inhibitors; replacement of 5-ester groups leading to increased stability.	Trinity College
19813747	12	Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks.	University of Bologna
19520578	11	Synthesis of novel purine nucleosides towards a selective inhibition of human butyrylcholinesterase.	Faculdade De Ci£Ncias Da Universidade De Lisboa
19505825	12	Structure-activity relationships of memoquin: Influence of the chain chirality in the multi-target mechanism of action.	Alma Mater Studiorum-Bologna University
19215141	8	Antioxidant and anticholinesterase activity evaluation of ent-kaurane diterpenoids from Sideritis arguta.	Istanbul University
	11	Synthesis and preliminary structure-activity relationships of 1-[(3-fluoro-4-pyridinyl)amino]-3-methyl-1H-indol-5-yl methyl carbamate (P10358), a novel acetylcholinesterase inhibitor	TBA
18817366	43	Isosorbide-2-carbamate esters: potent and selective butyrylcholinesterase inhibitors.	Trinity College
18786825	30	Tacrine based human cholinesterase inhibitors: synthesis of peptidic-tethered derivatives and their effect on potency and selectivity.	European Research Centre For Drug Discovery and Development (Natsyndrugs)
18686941	11	Synthesis and biological evaluation of (-)- and (+)-debromoflustramine B and its analogues as selective butyrylcholinesterase inhibitors.	Instituto PolitéCnico Nacional
18681480	14	Bioactive 5alpha-pregnane-type steroidal alkaloids from Sarcococca hookeriana.	Bielefeld University
18650096	17	Solid-phase synthesis and biological evaluation of a parallel library of 2,3-dihydro-1,5-benzothiazepines.	Quaid-I-Azam University
18605718	17	Inhibition of acetylcholinesterase, beta-amyloid aggregation, and NMDA receptors in Alzheimer's disease: a promising direction for the multi-target-directed ligands gold rush.	University of Bologna
18570368	27	Carbamates with differential mechanism of inhibition toward acetylcholinesterase and butyrylcholinesterase.	Dalhousie University
18524585	20	Design, synthesis and evaluation of isaindigotone derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors.	Sun Yat-Sen University
18419109	18	Benzofuran-based hybrid compounds for the inhibition of cholinesterase activity, beta amyloid aggregation, and abeta neurotoxicity.	University of Bologna
18396354	29	Design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors.	University of Bologna
12828454	8	New triterpenoid alkaloid cholinesterase inhibitors from Buxus hyrcana.	University of Karachi
18047264	10	Multi-target-directed drug design strategy: from a dual binding site acetylcholinesterase inhibitor to a trifunctional compound against Alzheimer's disease.	Bologna University
17918819	114	Synthesis and structure-activity relationship for a novel class of potent and selective carbamate-based inhibitors of hormone selective lipase with acute in vivo antilipolytic effects.	Novo Nordisk
17681794	43	Synthesis, in vitro assay, and molecular modeling of new piperidine derivatives having dual inhibitory potency against acetylcholinesterase and Abeta1-42 aggregation for Alzheimer's disease therapeutics.	Woosuk University
17681768	23	Selective reversible inhibition of human butyrylcholinesterase by aryl amide derivatives of phenothiazine.	Dalhousie University
17655212	56	Extensive SAR and computational studies of 3-{4-[(benzylmethylamino)methyl]phenyl}-6,7-dimethoxy-2H-2-chromenone (AP2238) derivatives.	University of Bologna
17399985	136	Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.	St. Jude Children'S Research Hospital
17181144	30	Novel multipotent tacrine-dihydropyridine hybrids with improved acetylcholinesterase inhibitory and neuroprotective activities as potential drugs for the treatment of Alzheimer's disease.	Laboratorio De Radicales Libres (Iqog, Csic)
17008100	54	Cholinesterase inhibitors: SAR and enzyme inhibitory activity of 3-[omega-(benzylmethylamino)alkoxy]xanthen-9-ones.	University of Bologna
16945529	42	6-Hydroxy- and 6-methoxy-beta-carbolines as acetyl- and butyrylcholinesterase inhibitors.	Friedrich-Schiller-UniversitäT Jena
16335932	7	cycloSal-PMEA and cycloAmb-PMEA: potentially new phosphonate prodrugs based on the cycloSal-pronucleotide approach.	University of Hamburg
15603953	13	Isoterreulactone A, a novel meroterpenoid with anti-acetylcholinesterase activity produced by Aspergillus terreus.	Korea Research Institute of Bioscience and Biotechnology
14711311	104	Synthesis and structure-activity relationship for a novel class of potent and selective carbamoyl-triazole based inhibitors of hormone sensitive lipase.	Novo Nordisk
14584959	55	Molecular docking studies of natural cholinesterase-inhibiting steroidal alkaloids from Sarcococca saligna.	University of Innsbruck
12824041	14	Synthesis and structure-activity relationships of open D-Ring galanthamine analogues.	Cnrs
32165042	24	Discovery of 9-phenylacridinediones as highly selective butyrylcholinesterase inhibitors through structure-based virtual screening.	University of The Western Cape
32008882	38	Design, synthesis and biological evaluation of novel carbamates as potential inhibitors of acetylcholinesterase and butyrylcholinesterase.	Jinan University
32787113	9	Discovery and Biological Evaluation of a Novel Highly Potent Selective Butyrylcholinsterase Inhibitor.	China Pharmaceutical University
32309949	50	Aromatic Esters of the Crinane Amaryllidaceae Alkaloid Ambelline as Selective Inhibitors of Butyrylcholinesterase.	University of Defence
32031378	17	Acetylene Group, Friend or Foe in Medicinal Chemistry.	St. John'S University
31864798	42	Propargylamine-derived multi-target directed ligands for Alzheimer's disease therapy.	Universidade De Lisboa
32435398	15	Chiral Separation, X-ray Structure, and Biological Evaluation of a Potent and Reversible Dual Binding Site AChE Inhibitor.	University of Bari Aldo Moro
30739821	57	Tacrines for Alzheimer's disease therapy. III. The PyridoTacrines.	Hospital Universitario De La Princesa
31901380	8	Selective acetylcholinesterase inhibitors derived from muscle relaxant dantrolene.	Tokyo University of Pharmacy and Life Sciences
31753696	24	Design, synthesis and cholinesterase inhibitory activity of novel spiropyrrolidine tethered imidazole heterocyclic hybrids.	King Saud University
30784883	96	Design and development of multitarget-directed N-Benzylpiperidine analogs as potential candidates for the treatment of Alzheimer's disease.	Indian Institute of Technology (Banaras Hindu University)
27405689	14	Discovery and Structure-Activity Relationships of a Highly Selective Butyrylcholinesterase Inhibitor by Structure-Based Virtual Screening.	The University of Queensland
30765302	26	Highly potent and selective aryl-1,2,3-triazolyl benzylpiperidine inhibitors toward butyrylcholinesterase in Alzheimer's disease.	University of S£O Paulo
31736307	30	Alkaloids from the Branches and Leaves of	Nanjing University of Science and Technology
31708262	11	Discovery of potent and selective butyrylcholinesterase inhibitors through the use of pharmacophore-based screening.	University of Kentucky
30685536	45	Indazolylketones as new multitarget cannabinoid drugs.	Instituto De Qu£Mica M£Dica (Csic)
31158754	47	Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease.	University of Bari Aldo Moro
30851693	85	Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease.	University of Hradec Kralove
30798053	66	Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3.	Cnrs
30683553	6	Synthesis, spectroscopic characterization, molecular docking and theoretical studies (DFT) of N-(4-aminophenylsulfonyl)-2-(4-isobutylphenyl) propanamide having potential enzyme inhibition applications.	University of Education
10346939	30	Synthesis of novel phenserine-based-selective inhibitors of butyrylcholinesterase for Alzheimer's disease.	National Institute On Aging Intramural Research Program
31300317	14	1,2,3-Triazole-containing hybrids as leads in medicinal chemistry: A recent overview.	Chinese Academy of Sciences
31272793	1	Sulfonamide derivatives as multi-target agents for complex diseases.	University of Massachusetts Boston
31255497	5	Rational approaches, design strategies, structure activity relationship and mechanistic insights for therapeutic coumarin hybrids.	Guru Nanak Dev University
10230623	10	Synthesis of dihydroxanthone derivatives and evaluation of their inhibitory activity against acetylcholinesterase: unique structural analogs of tacrine based on the BCD-ring of arisugacin.	University of Minnesota
30884327	18	Advancement of multi-target drug discoveries and promising applications in the field of Alzheimer's disease.	Jining Medical University
31724859	23	New Dual Small Molecules for Alzheimer's Disease Therapy Combining Histamine H	Universit£
31352246	67	Triazole derivatives as inhibitors of Alzheimer's disease: Current developments and structure-activity relationships.	Wuhan Institute of Technology
31185414	86	Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment.	Alma Mater Studiorum-University of Bologna
31376562	122	Tacrine-O-protected phenolics heterodimers as multitarget-directed ligands against Alzheimer's disease: Selective subnanomolar BuChE inhibitors.	Universidad De Sevilla
31609608	59	Dual-Acting Cholinesterase-Human Cannabinoid Receptor 2 Ligands Show Pronounced Neuroprotection in Vitro and Overadditive and Disease-Modifying Neuroprotective Effects in Vivo.	Julius Maximilian University of W£Rzburg
31265934	53	Carboxamides vs. methanimines: Crystal structures, binding interactions, photophysical studies, and biological evaluation of (indazole-5-yl)methanimines as monoamine oxidase B and acetylcholinesterase inhibitors.	Ntz Lab
31288978	29	Design, synthesis, and evaluation of novel N-(4-phenoxybenzyl)aniline derivatives targeting acetylcholinesterase, ?-amyloid aggregation and oxidative stress to treat Alzheimer's disease.	Indian Institute of Technology (Banaras Hindu University)
30744931	170	Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018).	Csir-Central Drug Research Institute
30771601	7	Synthesis and evaluation of tetrahydroisoquinoline-benzimidazole hybrids as multifunctional agents for the treatment of Alzheimer's disease.	Sun Yat-Sen University
30771604	75	Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase.	Alexandria University
31401465	52	Multi-target-directed-ligands acting as enzyme inhibitors and receptor ligands.	Julius Maximilian University of W£Rzburg
30701972	35	Isoquinoline Alkaloids from Berberis vulgaris as Potential Lead Compounds for the Treatment of Alzheimer's Disease.	Charles University
9357518	74	Novel tacrine analogues for potential use against Alzheimer's disease: potent and selective acetylcholinesterase inhibitors and 5-HT uptake inhibitors.	University of Strathclyde
30503937	93	Design and development of some phenyl benzoxazole derivatives as a potent acetylcholinesterase inhibitor with antioxidant property to enhance learning and memory.	Indian Institute of Technology (Banaras Hindu University)
9288171	28	Total syntheses and anticholinesterase activities of (3aS)-N(8)-norphysostigmine, (3aS)-N(8)-norphenserine, their antipodal isomers, and other N(8)-substituted analogues.	National Institute On Aging
30404719	48	4-tert-Pentylphenoxyalkyl derivatives - Histamine H	Jagiellonian University Medical College
30366255	81	Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors.	Universit£
31609115	50	Highly Selective Butyrylcholinesterase Inhibitors with Tunable Duration of Action by Chemical Modification of Transferable Carbamate Units Exhibit Pronounced Neuroprotective Effect in an Alzheimer's Disease Mouse Model.	Julius Maximilian University W£Rzburg
30910460	24	Bioactivity-guided identification of flavonoids with cholinesterase and ?-amyloid peptide aggregation inhibitory effects from the seeds of Millettia pachycarpa.	Sichuan University
31581002	70	Development of chalcone-O-alkylamine derivatives as multifunctional agents against Alzheimer's disease.	Chinese Academy of Sciences
31351393	17	A novel class of multitarget anti-Alzheimer benzohomoadamantane?chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors.	University of Barcelona
26827140	83	Synthesis, molecular docking and biological evaluation of N,N-disubstituted 2-aminothiazolines as a new class of butyrylcholinesterase and carboxylesterase inhibitors.	Institute of Physiologically Active Compounds Russian Academy of Sciences
26795115	34	Ferulic acid-carbazole hybrid compounds: Combination of cholinesterase inhibition, antioxidant and neuroprotection as multifunctional anti-Alzheimer agents.	Southeast University
26599534	22	Synthesis and evaluation of bis-thiazole derivatives as new anticancer agents.	Anadolu University
24508831	7	Synthesis, biological evaluation and molecular modeling study of novel tacrine-carbazole hybrids as potential multifunctional agents for the treatment of Alzheimer's disease.	Khon Kaen University
24140444	30	Quinones bearing non-steroidal anti-inflammatory fragments as multitarget ligands for Alzheimer's disease.	Alma Mater Studiorum University of Bologna
23838422	22	Synthesis, pharmacological assessment, and molecular modeling of 6-chloro-pyridonepezils: new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease.	Instituto De Qu£Mica Org£Nica General (Csic)
23791077	12	Selective inhibition of human acetylcholinesterase by xanthine derivatives: in vitro inhibition and molecular modeling investigations.	University of Waterloo
23719283	32	Synthesis, biological evaluation and molecular modeling of substituted 2-aminobenzimidazoles as novel inhibitors of acetylcholinesterase and butyrylcholinesterase.	Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University)
23540646	14	Design, synthesis and biological activity of multifunctional ?,?-unsaturated carbonyl scaffolds for Alzheimer's disease.	University of Massachusetts Boston
7636841	16	5,7-dihydro-3-[2-[1-(phenylmethyl)-4-piperidinyl]ethyl]-6H- pyrrolo[3,2-f]-1,2-benzisoxazol-6-one: a potent and centrally-selective inhibitor of acetylcholinesterase with an improved margin of safety.	Pfizer
30096650	102	Donepezil-butylated hydroxytoluene (BHT) hybrids as Anti-Alzheimer's disease agents with cholinergic, antioxidant, and neuroprotective properties.	China Pharmaceutical University
30031971	30	Multi-target-directed ligands for treating Alzheimer's disease: Butyrylcholinesterase inhibitors displaying antioxidant and neuroprotective activities.	University of Ljubljana
30025348	149	Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease.	Consejo Superior De Investigaciones Cient�Ficas (Iqm-Csic)
30351923	12	Potent, Irreversible Inhibition of Human Carboxylesterases by Tanshinone Anhydrides Isolated from Salvia miltiorrhiza ("Danshen").	St. Jude Children'S Research Hospital
30245401	61	Multi-target-directed ligands for Alzheimer's disease: Discovery of chromone-based monoamine oxidase/cholinesterase inhibitors.	University of Porto
30383374	20	Pyridinium Oximes with Ortho-Positioned Chlorine Moiety Exhibit Improved Physicochemical Properties and Efficient Reactivation of Human Acetylcholinesterase Inhibited by Several Nerve Agents.	Institute For Medical Research and Occupational Health
29541355	35	Dual GSK-3?/AChE Inhibitors as a New Strategy for Multitargeting Anti-Alzheimer's Disease Drug Discovery.	China Pharmaceutical University
29335209	16	Chameleon-like behavior of indolylpiperidines in complex with cholinesterases targets: Potent butyrylcholinesterase inhibitors.	University of S£O Paulo
29533874	76	The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease.	University of Defence
29466774	78	Synthesis and activity towards Alzheimer's disease in vitro: Tacrine, phenolic acid and ligustrazine hybrids.	Chinese Academy of Medical Sciences & Peking Union Medical College
28923380	44	Novel deoxyvasicinone derivatives as potent multitarget-directed ligands for the treatment of Alzheimer's disease: Design, synthesis, and biological evaluation.	Xinyang Normal University
28800459	68	Novel cinnamamide-dibenzylamine hybrids: Potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease.	China Pharmaceutical University
28797883	56	Design, synthesis and biological evaluation of novel coumarin-N-benzyl pyridinium hybrids as multi-target agents for the treatment of Alzheimer's disease.	Shanghai University of Traditional Chinese Medicine
29958119	28	Tacripyrimidines, the first tacrine-dihydropyrimidine hybrids, as multi-target-directed ligands for Alzheimer's disease.	Laboratory of Medicinal Chemistry (Iqog, Csic)
30040425	3	A Bioactive Resveratrol Trimer from the Stem Bark of the Sri Lankan Endemic Plant Vateria copallifera.	University of Colombo
29407958	15	Design, synthesis and biological evaluation of new coumarin-dithiocarbamate hybrids as multifunctional agents for the treatment of Alzheimer's disease.	Jiangxi University of Traditional Chinese Medicine
29126732	19	2-Arylbenzofurans from Artocarpus lakoocha and methyl ether analogs with potent cholinesterase inhibitory activity.	Srinakharinwirot University
29969030	24	Contilisant, a Tetratarget Small Molecule for Alzheimer's Disease Therapy Combining Cholinesterase, Monoamine Oxidase Inhibition, and H3R Antagonism with S1R Agonism Profile.	Iqog, Csic
29031070	8	Nature-based molecules combined with rivastigmine: A symbiotic approach for the synthesis of new agents against Alzheimer's disease.	University of Pisa
29031067	30	New pyridine derivatives as inhibitors of acetylcholinesterase and amyloid aggregation.	Sapienza University of Rome
28863358	21	From dual binding site acetylcholinesterase inhibitors to allosteric modulators: A new avenue for disease-modifying drugs in Alzheimer's disease.	University of S£O Paulo
28759875	30	An overview of benzo[b]thiophene-based medicinal chemistry.	Jain University
30017112	36	Developing hybrid molecule therapeutics for diverse enzyme inhibitory action: Active role of coumarin-based structural leads in drug discovery.	Abbottabad University of Science and Technology
2202827	55	Alfred Burger award address. Bioactive alkaloids. 4. Results of recent investigations with colchicine and physostigmine.	Niddk
28242552	30	Enzymatic and solid-phase synthesis of new donepezil-based L- and d-glutamic acid derivatives and their pharmacological evaluation in models related to Alzheimer's disease and cerebral ischemia.	Instituto De Qu£Mica M£Dica
28242549	86	Design, synthesis and evaluation of 2-arylethenyl-N-methylquinolinium derivatives as effective multifunctional agents for Alzheimer's disease treatment.	Sun Yat-Sen University
29033232	164	Design, synthesis and biological evaluation of phthalimide-alkylamine derivatives as balanced multifunctional cholinesterase and monoamine oxidase-B inhibitors for the treatment of Alzheimer's disease.	Nanyang Normal University
1507203	96	Synthesis and cholinergic properties of N-aryl-2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethylamino analogs of ranitidine.	University of South Carolina
29227101	30	The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity.	University of Ljubljana
28371641	32	Recent progress in the identification of selective butyrylcholinesterase inhibitors for Alzheimer's disease.	China Pharmaceutical University
29400965	83	Structure-Activity Relationships and Computational Investigations into the Development of Potent and Balanced Dual-Acting Butyrylcholinesterase Inhibitors and Human Cannabinoid Receptor 2 Ligands with Pro-Cognitive in Vivo Profiles.	Julius Maximilian University of W£Rzburg
28404526	23	Stereospecific cholinesterase inhibition by O,S-diethylphenylphosphonothioate.	University of Missouri St. Louis
28400237	19	Cytochrome P450 binding studies of novel tacrine derivatives: Predicting the risk of hepatotoxicity.	University of Waterloo
27603793	12	Investigating the Reaction Mechanism of F420-Dependent Glucose-6-phosphate Dehydrogenase from Mycobacterium tuberculosis: Kinetic Analysis of the Wild-Type and Mutant Enzymes.	The University of Texas At Arlington
10411562	36	Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles.	Merck Frosst Centre For Therapeutic Research
8996189	24	Cloning, expression and pharmacological characterization of rabbit adenosine A1 and A3 receptors.	Pfizer
18849971	56	Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases.	University of California San Francisco
19167885	24	Synthesis and SAR of potent LXR agonists containing an indole pharmacophore.	Gsk
18541433	45	Discovery and SAR of 2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer.	Abbott Laboratories
19143567	49	Fragment-based discovery of the pyrazol-4-yl urea (AT9283), a multitargeted kinase inhibitor with potent aurora kinase activity.	Astex
19022670	8	Potent inhibitors of HCV-NS3 protease derived from boronic acids.	Schering-Plough Research Institute
19193158	77	Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.	University of Tampere
18973287	87	Structural Requirements for Eszopiclone and Zolpidem Binding to the gamma-Aminobutyric Acid Type-A (GABAA) Receptor Are Different.	University of Wisconsin At Madison
18947224	54	Lead Optimization of 4-Acetylamino-2-(3,5-dimethylpyrazol-1-yl)-6-pyridylpyrimidines as A2A Adenosine Receptor Antagonists for the Treatment of Parkinson's Disease.	Neurocrine Bioscience
18983139	12	cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), A New Histamine H4R Antagonist that Blocks Pain Responses against Carrageenan-Induced Hyperalgesia.	Abbott Laboratories
18973288	34	Indazole-Based Liver X Receptor (LXR) Modulators with Maintained Atherosclerotic Lesion Reduction Activity but Diminished Stimulation of Hepatic Triglyceride Synthesis	Wyeth Research
18922779	15	Identification of a new JNK inhibitor targeting the JNK-JIP interaction site.	Burnham Institute For Medical Research
18942827	66	Design and Synthesis of Orally Bioavailable Benzimidazoles as Raf Kinase Inhibitors.	Novartis
18834108	22	Structure-based approach to the development of potent and selective inhibitors of dihydrofolate reductase from cryptosporidium.	University of Connecticut At Storrs
10639181	68	Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors.	Vanderbilt University School of Medicine
15239652	22	Structure-based design, synthesis, and structure-activity relationship studies of novel non-nucleoside adenosine deaminase inhibitors.	Fujisawa Pharmaceutical
14709046	4	A highly potent non-nucleoside adenosine deaminase inhibitor: efficient drug discovery by intentional lead hybridization.	Fujisawa Pharmaceutical
17941623	72	Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1.	St. Jude Research Hospital
17154493	13	4,5-dihydroxypyrimidine carboxamides and N-alkyl-5-hydroxypyrimidinone carboxamides are potent, selective HIV integrase inhibitors with good pharmacokinetic profiles in preclinical species.	Irbm-Mrl
17567119	7	Structural insight into the pharmacophore pocket of human glutamate carboxypeptidase II.	Nci-Fcrdc
16750629	28	p38 MAP kinase inhibitors. Part 3: SAR on 3,4-dihydropyrimido[4,5-d]pyrimidin-2-ones and 3,4-dihydropyrido[4,3-d]pyrimidin-2-ones.	Merck Research Laboratories