Compile Data Set for Download or QSAR

Found 63 hits Enz. Inhib. hit(s) with all data for entry = 2753   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM24206 (2-{4-[2-(azepan-1-yl)ethoxy]phenoxy}-1,3-benzoxazo...) Show SMILES C(CN1CCCCCC1)Oc1ccc(Oc2nc3ccccc3o2)cc1 Show InChI InChI=1S/C21H24N2O3/c1-2-6-14-23(13-5-1)15-16-24-17-9-11-18(12-10-17)25-21-22-19-7-3-4-8-20(19)26-21/h3-4,7-12H,1-2,5-6,13-16H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM24216 (1-{2-[4-(1,3-benzoxazol-2-yloxy)phenoxy]ethyl}-4-p...) Show SMILES OC1(CCN(CCOc2ccc(Oc3nc4ccccc4o3)cc2)CC1)c1ccccc1 Show InChI InChI=1S/C26H26N2O4/c29-26(20-6-2-1-3-7-20)14-16-28(17-15-26)18-19-30-21-10-12-22(13-11-21)31-25-27-23-8-4-5-9-24(23)32-25/h1-13,29H,14-19H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM24199 (2-{4-[2-(pyrrolidin-1-yl)ethoxy]phenoxy}-1,3-benzo...) Show SMILES C(CN1CCCC1)Oc1ccc(Oc2nc3ccccc3o2)cc1 Show InChI InChI=1S/C19H20N2O3/c1-2-6-18-17(5-1)20-19(24-18)23-16-9-7-15(8-10-16)22-14-13-21-11-3-4-12-21/h1-2,5-10H,3-4,11-14H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM24224 (1-{2-[4-(1,3-benzothiazol-2-yloxy)phenyl]ethyl}pip...) Show SMILES OC1CCN(CCc2ccc(Oc3nc4ccccc4s3)cc2)CC1 Show InChI InChI=1S/C20H22N2O2S/c23-16-10-13-22(14-11-16)12-9-15-5-7-17(8-6-15)24-20-21-18-3-1-2-4-19(18)25-20/h1-8,16,23H,9-14H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM24238 (Benzthiazole compound, 33p | N-(1-{[4-(1,3-benzoth...) Show SMILES OCC(=O)NC1CCN(Cc2ccc(Oc3nc4ccccc4s3)cc2)CC1 Show InChI InChI=1S/C21H23N3O3S/c25-14-20(26)22-16-9-11-24(12-10-16)13-15-5-7-17(8-6-15)27-21-23-18-3-1-2-4-19(18)28-21/h1-8,16,25H,9-14H2,(H,22,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	25
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM24212 (1-{2-[4-(1,3-benzoxazol-2-yloxy)phenoxy]ethyl}pipe...) Show SMILES OC1CCN(CCOc2ccc(Oc3nc4ccccc4o3)cc2)CC1 Show InChI InChI=1S/C20H22N2O4/c23-15-9-11-22(12-10-15)13-14-24-16-5-7-17(8-6-16)25-20-21-18-3-1-2-4-19(18)26-20/h1-8,15,23H,9-14H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM24235 (3-(1-{[4-(1,3-benzothiazol-2-yloxy)phenyl]methyl}p...) Show SMILES O=C1OCCN1C1CCN(Cc2ccc(Oc3nc4ccccc4s3)cc2)CC1 Show InChI InChI=1S/C22H23N3O3S/c26-22-25(13-14-27-22)17-9-11-24(12-10-17)15-16-5-7-18(8-6-16)28-21-23-19-3-1-2-4-20(19)29-21/h1-8,17H,9-15H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	25
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM24203 (2-{4-[2-(piperidin-1-yl)ethoxy]phenoxy}-1,3-benzox...) Show SMILES C(CN1CCCCC1)Oc1ccc(Oc2nc3ccccc3o2)cc1 Show InChI InChI=1S/C20H22N2O3/c1-4-12-22(13-5-1)14-15-23-16-8-10-17(11-9-16)24-20-21-18-6-2-3-7-19(18)25-20/h2-3,6-11H,1,4-5,12-15H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM24239 (1-{[4-(1,3-benzothiazol-2-yloxy)phenyl]methyl}pipe...) Show SMILES OC(=O)C1CCN(Cc2ccc(Oc3nc4ccccc4s3)cc2)CC1 Show InChI InChI=1S/C20H20N2O3S/c23-19(24)15-9-11-22(12-10-15)13-14-5-7-16(8-6-14)25-20-21-17-3-1-2-4-18(17)26-20/h1-8,15H,9-13H2,(H,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	25
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair				3D Structure (crystal)
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM24222 (3-(1-{2-[4-(1,3-benzothiazol-2-yloxy)phenoxy]ethyl...) Show SMILES O=C1OCCN1C1CCN(CCOc2ccc(Oc3nc4ccccc4s3)cc2)CC1 Show InChI InChI=1S/C23H25N3O4S/c27-23-26(14-16-29-23)17-9-11-25(12-10-17)13-15-28-18-5-7-19(8-6-18)30-22-24-20-3-1-2-4-21(20)31-22/h1-8,17H,9-16H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM24236 (Benzthiazole compound, 33n | N-(1-{[4-(1,3-benzoth...) Show SMILES CC(=O)NC1CCN(Cc2ccc(Oc3nc4ccccc4s3)cc2)CC1 Show InChI InChI=1S/C21H23N3O2S/c1-15(25)22-17-10-12-24(13-11-17)14-16-6-8-18(9-7-16)26-21-23-19-4-2-3-5-20(19)27-21/h2-9,17H,10-14H2,1H3,(H,22,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	25
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM24234 (1-(1-{[4-(1,3-benzothiazol-2-yloxy)phenyl]methyl}p...) Show SMILES O=C1CCCN1C1CCN(Cc2ccc(Oc3nc4ccccc4s3)cc2)CC1 Show InChI InChI=1S/C23H25N3O2S/c27-22-6-3-13-26(22)18-11-14-25(15-12-18)16-17-7-9-19(10-8-17)28-23-24-20-4-1-2-5-21(20)29-23/h1-2,4-5,7-10,18H,3,6,11-16H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	25
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM24227 (1-(1-{2-[4-(1,3-benzothiazol-2-yloxy)phenyl]ethyl}...) Show SMILES O=C1CCCN1C1CCN(CCc2ccc(Oc3nc4ccccc4s3)cc2)CC1 Show InChI InChI=1S/C24H27N3O2S/c28-23-6-3-14-27(23)19-12-16-26(17-13-19)15-11-18-7-9-20(10-8-18)29-24-25-21-4-1-2-5-22(21)30-24/h1-2,4-5,7-10,19H,3,6,11-17H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	25
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM24218 (1-{2-[4-(1,3-benzothiazol-2-yloxy)phenoxy]ethyl}pi...) Show SMILES NC(=O)C1CCN(CCOc2ccc(Oc3nc4ccccc4s3)cc2)CC1 Show InChI InChI=1S/C21H23N3O3S/c22-20(25)15-9-11-24(12-10-15)13-14-26-16-5-7-17(8-6-16)27-21-23-18-3-1-2-4-19(18)28-21/h1-8,15H,9-14H2,(H2,22,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM24215 ((1-{2-[4-(1,3-benzothiazol-2-yloxy)phenoxy]ethyl}p...) Show SMILES OCC1CCN(CCOc2ccc(Oc3nc4ccccc4s3)cc2)CC1 Show InChI InChI=1S/C21H24N2O3S/c24-15-16-9-11-23(12-10-16)13-14-25-17-5-7-18(8-6-17)26-21-22-19-3-1-2-4-20(19)27-21/h1-8,16,24H,9-15H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM24214 ((1-{2-[4-(1,3-benzoxazol-2-yloxy)phenoxy]ethyl}pip...) Show SMILES OCC1CCN(CCOc2ccc(Oc3nc4ccccc4o3)cc2)CC1 Show InChI InChI=1S/C21H24N2O4/c24-15-16-9-11-23(12-10-16)13-14-25-17-5-7-18(8-6-17)26-21-22-19-3-1-2-4-20(19)27-21/h1-8,16,24H,9-15H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM24201 (2-{4-[2-(pyrrolidin-1-yl)ethoxy]phenoxy}-1,3-benzo...) Show SMILES C(CN1CCCC1)Oc1ccc(Oc2nc3ccccc3s2)cc1 Show InChI InChI=1S/C19H20N2O2S/c1-2-6-18-17(5-1)20-19(24-18)23-16-9-7-15(8-10-16)22-14-13-21-11-3-4-12-21/h1-2,5-10H,3-4,11-14H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM24220 (1-(1-{2-[4-(1,3-benzothiazol-2-yloxy)phenoxy]ethyl...) Show SMILES O=C1CCCN1C1CCN(CCOc2ccc(Oc3nc4ccccc4s3)cc2)CC1 Show InChI InChI=1S/C24H27N3O3S/c28-23-6-3-13-27(23)18-11-14-26(15-12-18)16-17-29-19-7-9-20(10-8-19)30-24-25-21-4-1-2-5-22(21)31-24/h1-2,4-5,7-10,18H,3,6,11-17H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM24223 (2-{4-[2-(piperidin-1-yl)ethyl]phenoxy}-1,3-benzoth...) Show SMILES C(Cc1ccc(Oc2nc3ccccc3s2)cc1)N1CCCCC1 Show InChI InChI=1S/C20H22N2OS/c1-4-13-22(14-5-1)15-12-16-8-10-17(11-9-16)23-20-21-18-6-2-3-7-19(18)24-20/h2-3,6-11H,1,4-5,12-15H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM24233 (1-{[4-(1,3-benzothiazol-2-yloxy)phenyl]methyl}pipe...) Show SMILES NC(=O)C1CCN(Cc2ccc(Oc3nc4ccccc4s3)cc2)CC1 Show InChI InChI=1S/C20H21N3O2S/c21-19(24)15-9-11-23(12-10-15)13-14-5-7-16(8-6-14)25-20-22-17-3-1-2-4-18(17)26-20/h1-8,15H,9-13H2,(H2,21,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	25
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM24237 (Benzthiazole compound, 33o | [(1-{[4-(1,3-benzothi...) Show SMILES CC(=O)OCC(=O)NC1CCN(Cc2ccc(Oc3nc4ccccc4s3)cc2)CC1 Show InChI InChI=1S/C23H25N3O4S/c1-16(27)29-15-22(28)24-18-10-12-26(13-11-18)14-17-6-8-19(9-7-17)30-23-25-20-4-2-3-5-21(20)31-23/h2-9,18H,10-15H2,1H3,(H,24,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	25
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM24240 (2-{4-[3-(piperidin-1-yl)propoxy]phenoxy}-1,3-benzo...) Show SMILES C(COc1ccc(Oc2nc3ccccc3o2)cc1)CN1CCCCC1 Show InChI InChI=1S/C21H24N2O3/c1-4-13-23(14-5-1)15-6-16-24-17-9-11-18(12-10-17)25-21-22-19-7-2-3-8-20(19)26-21/h2-3,7-12H,1,4-6,13-16H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	25
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM24225 (1-{2-[4-(1,3-benzothiazol-2-yloxy)phenyl]ethyl}pip...) Show SMILES NC(=O)C1CCN(CCc2ccc(Oc3nc4ccccc4s3)cc2)CC1 Show InChI InChI=1S/C21H23N3O2S/c22-20(25)16-10-13-24(14-11-16)12-9-15-5-7-17(8-6-15)26-21-23-18-3-1-2-4-19(18)27-21/h1-8,16H,9-14H2,(H2,22,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM24228 (3-(1-{2-[4-(1,3-benzothiazol-2-yloxy)phenyl]ethyl}...) Show SMILES O=C1OCCN1C1CCN(CCc2ccc(Oc3nc4ccccc4s3)cc2)CC1 Show InChI InChI=1S/C23H25N3O3S/c27-23-26(15-16-28-23)18-10-13-25(14-11-18)12-9-17-5-7-19(8-6-17)29-22-24-20-3-1-2-4-21(20)30-22/h1-8,18H,9-16H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	25
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM24213 (1-{2-[4-(1,3-benzothiazol-2-yloxy)phenoxy]ethyl}pi...) Show SMILES OC1CCN(CCOc2ccc(Oc3nc4ccccc4s3)cc2)CC1 Show InChI InChI=1S/C20H22N2O3S/c23-15-9-11-22(12-10-15)13-14-24-16-5-7-17(8-6-16)25-20-21-18-3-1-2-4-19(18)26-20/h1-8,15,23H,9-14H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	31	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM24232 (1-{[4-(1,3-benzothiazol-2-yloxy)phenyl]methyl}pipe...) Show SMILES OC1CCN(Cc2ccc(Oc3nc4ccccc4s3)cc2)CC1 Show InChI InChI=1S/C19H20N2O2S/c22-15-9-11-21(12-10-15)13-14-5-7-16(8-6-14)23-19-20-17-3-1-2-4-18(17)24-19/h1-8,15,22H,9-13H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	25
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM24229 (Benzthiazole compound, 27n | N-(1-{2-[4-(1,3-benzo...) Show SMILES CC(=O)NC1CCN(CCc2ccc(Oc3nc4ccccc4s3)cc2)CC1 Show InChI InChI=1S/C22H25N3O2S/c1-16(26)23-18-11-14-25(15-12-18)13-10-17-6-8-19(9-7-17)27-22-24-20-4-2-3-5-21(20)28-22/h2-9,18H,10-15H2,1H3,(H,23,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	25
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM24230 (Benzthiazole compound, 27o | [(1-{2-[4-(1,3-benzot...) Show SMILES CC(=O)OCC(=O)NC1CCN(CCc2ccc(Oc3nc4ccccc4s3)cc2)CC1 Show InChI InChI=1S/C24H27N3O4S/c1-17(28)30-16-23(29)25-19-11-14-27(15-12-19)13-10-18-6-8-20(9-7-18)31-24-26-21-4-2-3-5-22(21)32-24/h2-9,19H,10-16H2,1H3,(H,25,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	25
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM24204 (2-{4-[2-(piperidin-1-yl)ethoxy]phenoxy}-1,3-benzot...) Show SMILES C(CN1CCCCC1)Oc1ccc(Oc2nc3ccccc3s2)cc1 Show InChI InChI=1S/C20H22N2O2S/c1-4-12-22(13-5-1)14-15-23-16-8-10-17(11-9-16)24-20-21-18-6-2-3-7-19(18)25-20/h2-3,6-11H,1,4-5,12-15H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	54	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM24209 (2-{4-[2-(morpholin-4-yl)ethoxy]phenoxy}-1,3-benzox...) Show SMILES C(CN1CCOCC1)Oc1ccc(Oc2nc3ccccc3o2)cc1 Show InChI InChI=1S/C19H20N2O4/c1-2-4-18-17(3-1)20-19(25-18)24-16-7-5-15(6-8-16)23-14-11-21-9-12-22-13-10-21/h1-8H,9-14H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	58	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM24231 (2-[4-(piperidin-1-ylmethyl)phenoxy]-1,3-benzothiaz...) Show SMILES C(N1CCCCC1)c1ccc(Oc2nc3ccccc3s2)cc1 Show InChI InChI=1S/C19H20N2OS/c1-4-12-21(13-5-1)14-15-8-10-16(11-9-15)22-19-20-17-6-2-3-7-18(17)23-19/h2-3,6-11H,1,4-5,12-14H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	59	n/a	n/a	n/a	n/a	n/a	25
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM24219 (1-{2-[4-(1,3-benzothiazol-2-yloxy)phenoxy]ethyl}pi...) Show SMILES NC1CCN(CCOc2ccc(Oc3nc4ccccc4s3)cc2)CC1 Show InChI InChI=1S/C20H23N3O2S/c21-15-9-11-23(12-10-15)13-14-24-16-5-7-17(8-6-16)25-20-22-18-3-1-2-4-19(18)26-20/h1-8,15H,9-14,21H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	66	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM24207 (2-{4-[2-(azepan-1-yl)ethoxy]phenoxy}-1,3-benzothia...) Show SMILES C(CN1CCCCCC1)Oc1ccc(Oc2nc3ccccc3s2)cc1 Show InChI InChI=1S/C21H24N2O2S/c1-2-6-14-23(13-5-1)15-16-24-17-9-11-18(12-10-17)25-21-22-19-7-3-4-8-20(19)26-21/h3-4,7-12H,1-2,5-6,13-16H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	66	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM24217 (1-{2-[4-(1,3-benzothiazol-2-yloxy)phenoxy]ethyl}-4...) Show SMILES OC1(CCN(CCOc2ccc(Oc3nc4ccccc4s3)cc2)CC1)c1ccccc1 Show InChI InChI=1S/C26H26N2O3S/c29-26(20-6-2-1-3-7-20)14-16-28(17-15-26)18-19-30-21-10-12-22(13-11-21)31-25-27-23-8-4-5-9-24(23)32-25/h1-13,29H,14-19H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	66	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM24221 (1-(1-{2-[4-(1,3-benzothiazol-2-yloxy)phenoxy]ethyl...) Show SMILES O=C1CCCCN1C1CCN(CCOc2ccc(Oc3nc4ccccc4s3)cc2)CC1 Show InChI InChI=1S/C25H29N3O3S/c29-24-7-3-4-14-28(24)19-12-15-27(16-13-19)17-18-30-20-8-10-21(11-9-20)31-25-26-22-5-1-2-6-23(22)32-25/h1-2,5-6,8-11,19H,3-4,7,12-18H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM24202 (2-{4-[2-(pyrrolidin-1-yl)ethoxy]phenoxy}-1H-1,3-be...) Show SMILES C(CN1CCCC1)Oc1ccc(Oc2nc3ccccc3[nH]2)cc1 Show InChI InChI=1S/C19H21N3O2/c1-2-6-18-17(5-1)20-19(21-18)24-16-9-7-15(8-10-16)23-14-13-22-11-3-4-12-22/h1-2,5-10H,3-4,11-14H2,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	84	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM24241 (2-{4-[3-(piperidin-1-yl)propoxy]phenoxy}-1,3-benzo...) Show SMILES C(COc1ccc(Oc2nc3ccccc3s2)cc1)CN1CCCCC1 Show InChI InChI=1S/C21H24N2O2S/c1-4-13-23(14-5-1)15-6-16-24-17-9-11-18(12-10-17)25-21-22-19-7-2-3-8-20(19)26-21/h2-3,7-12H,1,4-6,13-16H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	87	n/a	n/a	n/a	n/a	n/a	25
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM24205 (2-{4-[2-(piperidin-1-yl)ethoxy]phenoxy}-1H-1,3-ben...) Show SMILES C(CN1CCCCC1)Oc1ccc(Oc2nc3ccccc3[nH]2)cc1 Show InChI InChI=1S/C20H23N3O2/c1-4-12-23(13-5-1)14-15-24-16-8-10-17(11-9-16)25-20-21-18-6-2-3-7-19(18)22-20/h2-3,6-11H,1,4-5,12-15H2,(H,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM24208 (2-{4-[2-(azepan-1-yl)ethoxy]phenoxy}-1H-1,3-benzod...) Show SMILES C(CN1CCCCCC1)Oc1ccc(Oc2nc3ccccc3[nH]2)cc1 Show InChI InChI=1S/C21H25N3O2/c1-2-6-14-24(13-5-1)15-16-25-17-9-11-18(12-10-17)26-21-22-19-7-3-4-8-20(19)23-21/h3-4,7-12H,1-2,5-6,13-16H2,(H,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM24210 (4-{2-[4-(1,3-benzothiazol-2-yloxy)phenoxy]ethyl}mo...) Show SMILES C(CN1CCOCC1)Oc1ccc(Oc2nc3ccccc3s2)cc1 Show InChI InChI=1S/C19H20N2O3S/c1-2-4-18-17(3-1)20-19(25-18)24-16-7-5-15(6-8-16)23-14-11-21-9-12-22-13-10-21/h1-8H,9-14H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM24228 (3-(1-{2-[4-(1,3-benzothiazol-2-yloxy)phenyl]ethyl}...) Show SMILES O=C1OCCN1C1CCN(CCc2ccc(Oc3nc4ccccc4s3)cc2)CC1 Show InChI InChI=1S/C23H25N3O3S/c27-23-26(15-16-28-23)18-10-13-25(14-11-18)12-9-17-5-7-19(8-6-17)29-22-24-20-3-1-2-4-21(20)30-22/h1-8,18H,9-16H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical					Assay Description Compounds were assessed for their ability to displace [3H]astemizole using membranes from HEK-293 cells expressing the hERG K+ channel.				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM24242 (2-{4-[3-(piperidin-1-yl)propoxy]phenoxy}-1H-1,3-be...) Show SMILES C(COc1ccc(Oc2nc3ccccc3[nH]2)cc1)CN1CCCCC1 Show InChI InChI=1S/C21H25N3O2/c1-4-13-24(14-5-1)15-6-16-25-17-9-11-18(12-10-17)26-21-22-19-7-2-3-8-20(19)23-21/h2-3,7-12H,1,4-6,13-16H2,(H,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	710	n/a	n/a	n/a	n/a	n/a	25
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM24203 (2-{4-[2-(piperidin-1-yl)ethoxy]phenoxy}-1,3-benzox...) Show SMILES C(CN1CCCCC1)Oc1ccc(Oc2nc3ccccc3o2)cc1 Show InChI InChI=1S/C20H22N2O3/c1-4-12-22(13-5-1)14-15-23-16-8-10-17(11-9-16)24-20-21-18-6-2-3-7-19(18)25-20/h2-3,6-11H,1,4-5,12-15H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Compounds were assessed for their ability to displace [3H]astemizole using membranes from HEK-293 cells expressing the hERG K+ channel.				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM24227 (1-(1-{2-[4-(1,3-benzothiazol-2-yloxy)phenyl]ethyl}...) Show SMILES O=C1CCCN1C1CCN(CCc2ccc(Oc3nc4ccccc4s3)cc2)CC1 Show InChI InChI=1S/C24H27N3O2S/c28-23-6-3-14-27(23)19-12-16-26(17-13-19)15-11-18-7-9-20(10-8-18)29-24-25-21-4-1-2-5-22(21)30-24/h1-2,4-5,7-10,19H,3,6,11-17H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical					Assay Description Compounds were assessed for their ability to displace [3H]astemizole using membranes from HEK-293 cells expressing the hERG K+ channel.				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM24221 (1-(1-{2-[4-(1,3-benzothiazol-2-yloxy)phenoxy]ethyl...) Show SMILES O=C1CCCCN1C1CCN(CCOc2ccc(Oc3nc4ccccc4s3)cc2)CC1 Show InChI InChI=1S/C25H29N3O3S/c29-24-7-3-4-14-28(24)19-12-15-27(16-13-19)17-18-30-20-8-10-21(11-9-20)31-25-26-22-5-1-2-6-23(22)32-25/h1-2,5-6,8-11,19H,3-4,7,12-18H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	25
Johnson & Johnson Pharmaceutical					Assay Description Compounds were assessed for their ability to displace [3H]astemizole using membranes from HEK-293 cells expressing the hERG K+ channel.				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM24223 (2-{4-[2-(piperidin-1-yl)ethyl]phenoxy}-1,3-benzoth...) Show SMILES C(Cc1ccc(Oc2nc3ccccc3s2)cc1)N1CCCCC1 Show InChI InChI=1S/C20H22N2OS/c1-4-13-22(14-5-1)15-12-16-8-10-17(11-9-16)23-20-21-18-6-2-3-7-19(18)24-20/h2-3,6-11H,1,4-5,12-15H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Compounds were assessed for their ability to displace [3H]astemizole using membranes from HEK-293 cells expressing the hERG K+ channel.				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM24222 (3-(1-{2-[4-(1,3-benzothiazol-2-yloxy)phenoxy]ethyl...) Show SMILES O=C1OCCN1C1CCN(CCOc2ccc(Oc3nc4ccccc4s3)cc2)CC1 Show InChI InChI=1S/C23H25N3O4S/c27-23-26(14-16-29-23)17-9-11-25(12-10-17)13-15-28-18-5-7-19(8-6-18)30-22-24-20-3-1-2-4-21(20)31-22/h1-8,17H,9-16H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	25
Johnson & Johnson Pharmaceutical					Assay Description Compounds were assessed for their ability to displace [3H]astemizole using membranes from HEK-293 cells expressing the hERG K+ channel.				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM24220 (1-(1-{2-[4-(1,3-benzothiazol-2-yloxy)phenoxy]ethyl...) Show SMILES O=C1CCCN1C1CCN(CCOc2ccc(Oc3nc4ccccc4s3)cc2)CC1 Show InChI InChI=1S/C24H27N3O3S/c28-23-6-3-13-27(23)18-11-14-26(15-12-18)16-17-29-19-7-9-20(10-8-19)30-24-25-21-4-1-2-5-22(21)31-24/h1-2,4-5,7-10,18H,3,6,11-17H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	25
Johnson & Johnson Pharmaceutical					Assay Description Compounds were assessed for their ability to displace [3H]astemizole using membranes from HEK-293 cells expressing the hERG K+ channel.				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM24211 (4-{2-[4-(1H-1,3-benzodiazol-2-yloxy)phenoxy]ethyl}...) Show SMILES C(CN1CCOCC1)Oc1ccc(Oc2nc3ccccc3[nH]2)cc1 Show InChI InChI=1S/C19H21N3O3/c1-2-4-18-17(3-1)20-19(21-18)25-16-7-5-15(6-8-16)24-14-11-22-9-12-23-13-10-22/h1-8H,9-14H2,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM24224 (1-{2-[4-(1,3-benzothiazol-2-yloxy)phenyl]ethyl}pip...) Show SMILES OC1CCN(CCc2ccc(Oc3nc4ccccc4s3)cc2)CC1 Show InChI InChI=1S/C20H22N2O2S/c23-16-10-13-22(14-11-16)12-9-15-5-7-17(8-6-15)24-20-21-18-3-1-2-4-19(18)25-20/h1-8,16,23H,9-14H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Compounds were assessed for their ability to displace [3H]astemizole using membranes from HEK-293 cells expressing the hERG K+ channel.				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair

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