Found 32 hits Enz. Inhib. hit(s) with all data for entry = 50030942 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50304315
(CHEMBL593465 | trans-3-Oxo-N-(2-phenyl-2H-1,2,3-tr...)Show SMILES O=C(Nc1cnn(n1)-c1ccccc1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ccncc21 |r,wU:17.22,wD:14.15,(-4.09,-21.75,;-3.32,-23.08,;-1.78,-23.08,;-.88,-24.33,;.67,-24.33,;1.14,-25.79,;-.1,-26.7,;-1.35,-25.79,;-.1,-28.23,;-1.44,-29,;-1.44,-30.53,;-.11,-31.31,;1.23,-30.53,;1.23,-28.99,;-4.09,-24.41,;-5.63,-24.41,;-6.41,-25.75,;-5.63,-27.07,;-4.09,-27.07,;-3.33,-25.75,;-4.71,-28.33,;-5.62,-29.59,;-5.15,-31.05,;-7.1,-29.11,;-8.43,-29.88,;-9.77,-29.11,;-9.76,-27.56,;-8.43,-26.79,;-7.1,-27.56,)| Show InChI InChI=1S/C21H19N5O3/c27-19(24-18-13-23-26(25-18)15-4-2-1-3-5-15)14-6-9-21(10-7-14)17-12-22-11-8-16(17)20(28)29-21/h1-5,8,11-14H,6-7,9-10H2,(H,24,25,27)/t14-,21- | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.890 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human recombinant Y5 receptor |
Bioorg Med Chem 17: 6971-82 (2009)
Article DOI: 10.1016/j.bmc.2009.08.019
BindingDB Entry DOI: 10.7270/Q2P26Z62 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50304301
(CHEMBL595790 | trans-N-[1-(3-Fluorophenyl)-1H-pyra...)Show SMILES Fc1ccc(cc1)-n1ccc(NC(=O)[C@H]2CC[C@@]3(CC2)OC(=O)c2ccncc32)n1 |r,wU:17.21,wD:14.14,(.68,-45.87,;.68,-44.33,;-.66,-43.55,;-.65,-42.02,;.68,-41.25,;2.01,-42.01,;2.02,-43.55,;.68,-39.72,;1.93,-38.81,;1.45,-37.35,;-.09,-37.35,;-.99,-36.1,;-2.53,-36.1,;-3.3,-34.77,;-3.31,-37.43,;-4.85,-37.43,;-5.62,-38.77,;-4.85,-40.09,;-3.31,-40.09,;-2.54,-38.77,;-3.93,-41.35,;-4.84,-42.61,;-4.36,-44.07,;-6.31,-42.13,;-7.65,-42.9,;-8.98,-42.13,;-8.98,-40.58,;-7.65,-39.81,;-6.31,-40.58,;-.56,-38.81,)| Show InChI InChI=1S/C22H19FN4O3/c23-15-1-3-16(4-2-15)27-12-8-19(26-27)25-20(28)14-5-9-22(10-6-14)18-13-24-11-7-17(18)21(29)30-22/h1-4,7-8,11-14H,5-6,9-10H2,(H,25,26,28)/t14-,22- | KEGG
UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.920 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human recombinant Y5 receptor |
Bioorg Med Chem 17: 6971-82 (2009)
Article DOI: 10.1016/j.bmc.2009.08.019
BindingDB Entry DOI: 10.7270/Q2P26Z62 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50304313
(CHEMBL607037 | trans-3-Oxo-N-(2-phenyl-1,3-thiazol...)Show SMILES O=C(Nc1csc(n1)-c1ccccc1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ccncc21 |r,wU:17.22,wD:14.15,(-3.64,-7.7,;-2.87,-9.03,;-1.33,-9.04,;-.39,-10.26,;1.15,-10.22,;1.66,-11.67,;.44,-12.61,;-.83,-11.74,;.48,-14.15,;-.83,-14.95,;-.79,-16.49,;.56,-17.22,;1.88,-16.41,;1.83,-14.88,;-3.64,-10.37,;-5.18,-10.37,;-5.95,-11.7,;-5.18,-13.03,;-3.64,-13.03,;-2.87,-11.7,;-4.26,-14.29,;-5.17,-15.54,;-4.7,-17.01,;-6.65,-15.06,;-7.98,-15.83,;-9.31,-15.06,;-9.31,-13.52,;-7.98,-12.75,;-6.65,-13.51,)| Show InChI InChI=1S/C22H19N3O3S/c26-19(24-18-13-29-20(25-18)15-4-2-1-3-5-15)14-6-9-22(10-7-14)17-12-23-11-8-16(17)21(27)28-22/h1-5,8,11-14H,6-7,9-10H2,(H,24,26)/t14-,22- | KEGG
UniProtKB/SwissProt
antibodypedia
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human recombinant Y5 receptor |
Bioorg Med Chem 17: 6971-82 (2009)
Article DOI: 10.1016/j.bmc.2009.08.019
BindingDB Entry DOI: 10.7270/Q2P26Z62 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50304298
(CHEMBL595120 | trans-3-Oxo-N-(1-phenyl-1H-pyrazol-...)Show SMILES O=C(Nc1cnn(c1)-c1ccccc1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ncccc21 |r,wU:17.22,wD:14.15,(-4.96,-20.66,;-4.19,-21.99,;-2.65,-21.99,;-1.77,-23.26,;-.23,-23.29,;.22,-24.77,;-1.05,-25.64,;-2.28,-24.71,;-1.08,-27.17,;-2.44,-27.91,;-2.47,-29.45,;-1.16,-30.25,;.2,-29.51,;.23,-27.97,;-4.96,-23.32,;-6.5,-23.32,;-7.28,-24.66,;-6.5,-25.99,;-4.96,-25.99,;-4.2,-24.66,;-5.58,-27.24,;-6.49,-28.5,;-6.02,-29.96,;-7.97,-28.02,;-9.3,-28.79,;-10.64,-28.02,;-10.63,-26.48,;-9.31,-25.7,;-7.97,-26.47,)| Show InChI InChI=1S/C22H20N4O3/c27-20(25-16-13-24-26(14-16)17-5-2-1-3-6-17)15-8-10-22(11-9-15)18-7-4-12-23-19(18)21(28)29-22/h1-7,12-15H,8-11H2,(H,25,27)/t15-,22- | KEGG
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human recombinant Y5 receptor |
Bioorg Med Chem 17: 6971-82 (2009)
Article DOI: 10.1016/j.bmc.2009.08.019
BindingDB Entry DOI: 10.7270/Q2P26Z62 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50304300
(CHEMBL595573 | trans-N-[1-(2-fluorophenyl)-3-pyraz...)Show SMILES Fc1ccccc1-n1ccc(NC(=O)[C@H]2CC[C@@]3(CC2)OC(=O)c2ccncc32)n1 |r,wU:17.21,wD:14.14,(16.87,-28.98,;15.54,-29.75,;15.54,-31.28,;14.2,-32.06,;12.87,-31.29,;12.87,-29.75,;14.21,-28.98,;14.21,-27.45,;15.45,-26.55,;14.98,-25.08,;13.44,-25.08,;12.53,-23.84,;10.99,-23.84,;10.22,-22.5,;10.22,-25.17,;8.68,-25.17,;7.91,-26.5,;8.68,-27.83,;10.22,-27.83,;10.99,-26.5,;9.6,-29.09,;8.69,-30.34,;9.16,-31.81,;7.21,-29.86,;5.88,-30.63,;4.55,-29.86,;4.55,-28.32,;5.88,-27.55,;7.21,-28.31,;12.96,-26.54,)| Show InChI InChI=1S/C22H19FN4O3/c23-17-3-1-2-4-18(17)27-12-8-19(26-27)25-20(28)14-5-9-22(10-6-14)16-13-24-11-7-15(16)21(29)30-22/h1-4,7-8,11-14H,5-6,9-10H2,(H,25,26,28)/t14-,22- | KEGG
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| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human recombinant Y5 receptor |
Bioorg Med Chem 17: 6971-82 (2009)
Article DOI: 10.1016/j.bmc.2009.08.019
BindingDB Entry DOI: 10.7270/Q2P26Z62 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50304303
(CHEMBL593934 | trans-3-Oxo-N-(5-phenylpyrazin-2-yl...)Show SMILES O=C(Nc1cnc(cn1)-c1ccccc1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ccccc21 |r,wU:18.23,wD:15.16,(-4.29,5.75,;-3.52,4.41,;-1.98,4.41,;-1.21,3.08,;-1.99,1.75,;-1.22,.41,;.32,.41,;1.09,1.75,;.32,3.08,;1.09,-.92,;.32,-2.25,;1.08,-3.58,;2.63,-3.58,;3.4,-2.24,;2.62,-.91,;-4.29,3.08,;-5.83,3.08,;-6.61,1.75,;-5.83,.42,;-4.29,.42,;-3.53,1.75,;-4.91,-.84,;-5.83,-2.09,;-5.35,-3.56,;-7.3,-1.61,;-8.63,-2.39,;-9.97,-1.61,;-9.97,-.07,;-8.64,.7,;-7.3,-.06,)| Show InChI InChI=1S/C24H21N3O3/c28-22(27-21-15-25-20(14-26-21)16-6-2-1-3-7-16)17-10-12-24(13-11-17)19-9-5-4-8-18(19)23(29)30-24/h1-9,14-15,17H,10-13H2,(H,26,27,28)/t17-,24- | KEGG
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human recombinant Y5 receptor |
Bioorg Med Chem 17: 6971-82 (2009)
Article DOI: 10.1016/j.bmc.2009.08.019
BindingDB Entry DOI: 10.7270/Q2P26Z62 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Rat 6B) | BDBM50304297
(CHEMBL594163 | trans-3-Oxo-N-(1-phenyl-1H-pyrazol-...)Show SMILES O=C(Nc1ccn(n1)-c1ccccc1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ncccc21 |r,wU:17.22,wD:14.15,(24.81,-8.6,;25.58,-9.94,;27.12,-9.94,;28,-11.21,;29.55,-11.24,;29.99,-12.71,;28.72,-13.59,;27.5,-12.65,;28.69,-15.12,;27.34,-15.86,;27.3,-17.4,;28.62,-18.2,;29.97,-17.45,;30,-15.91,;24.81,-11.27,;23.27,-11.27,;22.5,-12.6,;23.27,-13.93,;24.81,-13.93,;25.58,-12.6,;24.19,-15.19,;23.28,-16.44,;23.75,-17.91,;21.8,-15.96,;20.47,-16.74,;19.14,-15.96,;19.14,-14.42,;20.47,-13.65,;21.8,-14.41,)| Show InChI InChI=1S/C22H20N4O3/c27-20(24-18-10-14-26(25-18)16-5-2-1-3-6-16)15-8-11-22(12-9-15)17-7-4-13-23-19(17)21(28)29-22/h1-7,10,13-15H,8-9,11-12H2,(H,24,25,27)/t15-,22- | UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of rat Y5 receptor |
Bioorg Med Chem 17: 6971-82 (2009)
Article DOI: 10.1016/j.bmc.2009.08.019
BindingDB Entry DOI: 10.7270/Q2P26Z62 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50301656
(CHEMBL567527 | trans-1'-oxo-N-(5-phenylpyrimidin-2...)Show SMILES O=C(Nc1ncc(cn1)-c1ccccc1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ccncc21 |r,wU:18.23,wD:15.16,(28.35,-35.04,;29.11,-36.37,;30.65,-36.38,;31.49,-37.67,;30.78,-39.03,;31.62,-40.33,;33.16,-40.25,;33.86,-38.87,;33.02,-37.58,;34,-41.54,;33.29,-42.91,;34.13,-44.2,;35.67,-44.13,;36.37,-42.75,;35.53,-41.46,;28.34,-37.71,;26.8,-37.71,;26.03,-39.04,;26.8,-40.37,;28.34,-40.37,;29.11,-39.04,;27.72,-41.62,;26.81,-42.88,;27.29,-44.34,;25.33,-42.4,;24,-43.17,;22.67,-42.4,;22.67,-40.86,;24,-40.09,;25.33,-40.85,)| Show InChI InChI=1S/C23H20N4O3/c28-20(27-22-25-12-17(13-26-22)15-4-2-1-3-5-15)16-6-9-23(10-7-16)19-14-24-11-8-18(19)21(29)30-23/h1-5,8,11-14,16H,6-7,9-10H2,(H,25,26,27,28)/t16-,23- | KEGG
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human recombinant Y5 receptor |
Bioorg Med Chem 17: 6971-82 (2009)
Article DOI: 10.1016/j.bmc.2009.08.019
BindingDB Entry DOI: 10.7270/Q2P26Z62 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50304316
(CHEMBL594164 | trans-N-[1-(4-Fluorophenyl)-1H-pyra...)Show SMILES Fc1cccc(c1)-n1ccc(NC(=O)[C@H]2CC[C@@]3(CC2)OC(=O)c2ccncc32)n1 |r,wU:17.21,wD:14.14,(32.55,-32.84,;31.21,-32.08,;29.88,-32.85,;28.54,-32.08,;28.54,-30.54,;29.88,-29.78,;31.21,-30.54,;29.88,-28.24,;31.13,-27.34,;30.65,-25.87,;29.11,-25.88,;28.2,-24.63,;26.66,-24.63,;25.9,-23.29,;25.89,-25.96,;24.35,-25.96,;23.58,-27.3,;24.35,-28.62,;25.89,-28.62,;26.66,-27.3,;25.27,-29.88,;24.36,-31.14,;24.84,-32.6,;22.88,-30.66,;21.55,-31.43,;20.22,-30.66,;20.22,-29.11,;21.55,-28.34,;22.88,-29.11,;28.63,-27.34,)| Show InChI InChI=1S/C22H19FN4O3/c23-15-2-1-3-16(12-15)27-11-7-19(26-27)25-20(28)14-4-8-22(9-5-14)18-13-24-10-6-17(18)21(29)30-22/h1-3,6-7,10-14H,4-5,8-9H2,(H,25,26,28)/t14-,22- | KEGG
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PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human recombinant Y5 receptor |
Bioorg Med Chem 17: 6971-82 (2009)
Article DOI: 10.1016/j.bmc.2009.08.019
BindingDB Entry DOI: 10.7270/Q2P26Z62 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50301651
(CHEMBL568370 | trans-3'-oxo-N-(5-phenylpyrimidin-2...)Show SMILES O=C(Nc1ncc(cn1)-c1ccccc1)[C@H]1CC[C@@]2(CC1)OC(=O)c1cnccc21 |r,wU:18.23,wD:15.16,(26.14,-22.21,;26.91,-23.55,;28.45,-23.55,;29.28,-24.84,;28.58,-26.21,;29.41,-27.5,;30.95,-27.43,;31.65,-26.05,;30.81,-24.76,;31.79,-28.72,;31.08,-30.09,;31.92,-31.38,;33.46,-31.3,;34.16,-29.92,;33.32,-28.63,;26.13,-24.88,;24.59,-24.88,;23.82,-26.21,;24.59,-27.54,;26.13,-27.54,;26.9,-26.21,;25.51,-28.8,;24.6,-30.05,;25.08,-31.52,;23.13,-29.58,;21.79,-30.35,;20.46,-29.58,;20.46,-28.03,;21.79,-27.26,;23.12,-28.02,)| Show InChI InChI=1S/C23H20N4O3/c28-20(27-22-25-12-17(13-26-22)15-4-2-1-3-5-15)16-6-9-23(10-7-16)19-8-11-24-14-18(19)21(29)30-23/h1-5,8,11-14,16H,6-7,9-10H2,(H,25,26,27,28)/t16-,23- | KEGG
UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human recombinant Y5 receptor |
Bioorg Med Chem 17: 6971-82 (2009)
Article DOI: 10.1016/j.bmc.2009.08.019
BindingDB Entry DOI: 10.7270/Q2P26Z62 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50304310
(CHEMBL596264 | trans-3-Oxo-N-(5-phenylisoxazol-3-y...)Show SMILES O=C(Nc1cc(on1)-c1ccccc1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ccncc21 |r,wU:17.22,wD:14.15,(-3.73,5.98,;-2.96,4.65,;-1.42,4.65,;-.52,3.4,;-1,1.93,;.24,1.03,;1.49,1.93,;1.01,3.39,;.24,-.51,;-1.1,-1.28,;-1.1,-2.82,;.23,-3.59,;1.57,-2.81,;1.57,-1.28,;-3.73,3.31,;-5.27,3.31,;-6.05,1.98,;-5.27,.65,;-3.73,.65,;-2.97,1.98,;-4.35,-.6,;-5.27,-1.86,;-4.79,-3.32,;-6.74,-1.38,;-8.07,-2.15,;-9.41,-1.38,;-9.41,.16,;-8.08,.93,;-6.74,.17,)| Show InChI InChI=1S/C22H19N3O4/c26-20(24-19-12-18(29-25-19)14-4-2-1-3-5-14)15-6-9-22(10-7-15)17-13-23-11-8-16(17)21(27)28-22/h1-5,8,11-13,15H,6-7,9-10H2,(H,24,25,26)/t15-,22- | KEGG
UniProtKB/SwissProt
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human recombinant Y5 receptor |
Bioorg Med Chem 17: 6971-82 (2009)
Article DOI: 10.1016/j.bmc.2009.08.019
BindingDB Entry DOI: 10.7270/Q2P26Z62 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50304312
(CHEMBL604480 | trans-3-Oxo-N-(5-phenylpyridin-2-yl...)Show SMILES O=C(Nc1ccc(cn1)-c1ccccc1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ccncc21 |r,wU:18.23,wD:15.16,(24.78,5.17,;25.55,3.84,;27.09,3.84,;27.93,2.54,;27.22,1.18,;28.05,-.12,;29.59,-.04,;30.29,1.34,;29.45,2.63,;30.43,-1.33,;29.72,-2.7,;30.56,-3.99,;32.1,-3.92,;32.8,-2.53,;31.96,-1.25,;24.78,2.51,;23.24,2.51,;22.47,1.17,;23.24,-.16,;24.78,-.16,;25.55,1.17,;24.16,-1.41,;23.25,-2.67,;23.72,-4.13,;21.77,-2.19,;20.44,-2.96,;19.11,-2.19,;19.11,-.65,;20.44,.13,;21.77,-.64,)| Show InChI InChI=1S/C24H21N3O3/c28-22(27-21-7-6-18(14-26-21)16-4-2-1-3-5-16)17-8-11-24(12-9-17)20-15-25-13-10-19(20)23(29)30-24/h1-7,10,13-15,17H,8-9,11-12H2,(H,26,27,28)/t17-,24- | KEGG
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| n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human recombinant Y5 receptor |
Bioorg Med Chem 17: 6971-82 (2009)
Article DOI: 10.1016/j.bmc.2009.08.019
BindingDB Entry DOI: 10.7270/Q2P26Z62 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Rat 6B) | BDBM50304301
(CHEMBL595790 | trans-N-[1-(3-Fluorophenyl)-1H-pyra...)Show SMILES Fc1ccc(cc1)-n1ccc(NC(=O)[C@H]2CC[C@@]3(CC2)OC(=O)c2ccncc32)n1 |r,wU:17.21,wD:14.14,(.68,-45.87,;.68,-44.33,;-.66,-43.55,;-.65,-42.02,;.68,-41.25,;2.01,-42.01,;2.02,-43.55,;.68,-39.72,;1.93,-38.81,;1.45,-37.35,;-.09,-37.35,;-.99,-36.1,;-2.53,-36.1,;-3.3,-34.77,;-3.31,-37.43,;-4.85,-37.43,;-5.62,-38.77,;-4.85,-40.09,;-3.31,-40.09,;-2.54,-38.77,;-3.93,-41.35,;-4.84,-42.61,;-4.36,-44.07,;-6.31,-42.13,;-7.65,-42.9,;-8.98,-42.13,;-8.98,-40.58,;-7.65,-39.81,;-6.31,-40.58,;-.56,-38.81,)| Show InChI InChI=1S/C22H19FN4O3/c23-15-1-3-16(4-2-15)27-12-8-19(26-27)25-20(28)14-5-9-22(10-6-14)18-13-24-11-7-17(18)21(29)30-22/h1-4,7-8,11-14H,5-6,9-10H2,(H,25,26,28)/t14-,22- | UniProtKB/SwissProt
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| n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of rat Y5 receptor |
Bioorg Med Chem 17: 6971-82 (2009)
Article DOI: 10.1016/j.bmc.2009.08.019
BindingDB Entry DOI: 10.7270/Q2P26Z62 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Rat 6B) | BDBM50304300
(CHEMBL595573 | trans-N-[1-(2-fluorophenyl)-3-pyraz...)Show SMILES Fc1ccccc1-n1ccc(NC(=O)[C@H]2CC[C@@]3(CC2)OC(=O)c2ccncc32)n1 |r,wU:17.21,wD:14.14,(16.87,-28.98,;15.54,-29.75,;15.54,-31.28,;14.2,-32.06,;12.87,-31.29,;12.87,-29.75,;14.21,-28.98,;14.21,-27.45,;15.45,-26.55,;14.98,-25.08,;13.44,-25.08,;12.53,-23.84,;10.99,-23.84,;10.22,-22.5,;10.22,-25.17,;8.68,-25.17,;7.91,-26.5,;8.68,-27.83,;10.22,-27.83,;10.99,-26.5,;9.6,-29.09,;8.69,-30.34,;9.16,-31.81,;7.21,-29.86,;5.88,-30.63,;4.55,-29.86,;4.55,-28.32,;5.88,-27.55,;7.21,-28.31,;12.96,-26.54,)| Show InChI InChI=1S/C22H19FN4O3/c23-17-3-1-2-4-18(17)27-12-8-19(26-27)25-20(28)14-5-9-22(10-6-14)16-13-24-11-7-15(16)21(29)30-22/h1-4,7-8,11-14H,5-6,9-10H2,(H,25,26,28)/t14-,22- | UniProtKB/SwissProt
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| n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of rat Y5 receptor |
Bioorg Med Chem 17: 6971-82 (2009)
Article DOI: 10.1016/j.bmc.2009.08.019
BindingDB Entry DOI: 10.7270/Q2P26Z62 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50301644
(CHEMBL568144 | trans-3-Oxo-N-(5-phenylpyrimidin-2-...)Show SMILES O=C(Nc1ncc(cn1)-c1ccccc1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ncccc21 |r,wU:18.23,wD:15.16,(27.63,5.75,;28.4,4.41,;29.94,4.41,;30.71,3.08,;29.93,1.75,;30.7,.41,;32.24,.41,;33.01,1.75,;32.24,3.08,;33.01,-.92,;32.24,-2.25,;33,-3.58,;34.55,-3.58,;35.32,-2.24,;34.54,-.91,;27.63,3.08,;26.09,3.08,;25.31,1.75,;26.09,.42,;27.63,.42,;28.39,1.75,;27.01,-.84,;26.09,-2.09,;26.57,-3.56,;24.62,-1.61,;23.29,-2.39,;21.95,-1.61,;21.95,-.07,;23.28,.7,;24.62,-.06,)| Show InChI InChI=1S/C23H20N4O3/c28-20(27-22-25-13-17(14-26-22)15-5-2-1-3-6-15)16-8-10-23(11-9-16)18-7-4-12-24-19(18)21(29)30-23/h1-7,12-14,16H,8-11H2,(H,25,26,27,28)/t16-,23- | KEGG
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| n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human recombinant Y5 receptor |
Bioorg Med Chem 17: 6971-82 (2009)
Article DOI: 10.1016/j.bmc.2009.08.019
BindingDB Entry DOI: 10.7270/Q2P26Z62 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50304309
(CHEMBL607144 | trans-3-Oxo-N-(5-phenylpyrazin-2-yl...)Show SMILES O=C(Nc1cnc(cn1)-c1ccccc1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ccncc21 |r,wU:18.23,wD:15.16,(12.25,-35.6,;13.01,-36.93,;14.55,-36.94,;15.39,-38.23,;14.68,-39.59,;15.52,-40.89,;17.06,-40.81,;17.76,-39.43,;16.92,-38.14,;17.9,-42.1,;17.19,-43.47,;18.03,-44.76,;19.57,-44.69,;20.27,-43.31,;19.43,-42.02,;12.24,-38.27,;10.7,-38.27,;9.93,-39.6,;10.7,-40.93,;12.24,-40.93,;13.01,-39.6,;11.62,-42.18,;10.71,-43.44,;11.19,-44.9,;9.23,-42.96,;7.9,-43.73,;6.57,-42.96,;6.57,-41.42,;7.9,-40.65,;9.23,-41.41,)| Show InChI InChI=1S/C23H20N4O3/c28-21(27-20-14-25-19(13-26-20)15-4-2-1-3-5-15)16-6-9-23(10-7-16)18-12-24-11-8-17(18)22(29)30-23/h1-5,8,11-14,16H,6-7,9-10H2,(H,26,27,28)/t16-,23- | KEGG
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| n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human recombinant Y5 receptor |
Bioorg Med Chem 17: 6971-82 (2009)
Article DOI: 10.1016/j.bmc.2009.08.019
BindingDB Entry DOI: 10.7270/Q2P26Z62 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Rat 6B) | BDBM50304299
(CHEMBL595560 | trans-3-Oxo-N-(1-phenyl-1H-pyrazol-...)Show SMILES O=C(Nc1ccn(n1)-c1ccccc1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ccncc21 |r,wU:17.22,wD:14.15,(12.31,-8.24,;13.08,-9.57,;14.62,-9.57,;15.45,-10.87,;16.99,-10.95,;17.38,-12.44,;16.09,-13.28,;14.9,-12.31,;16.01,-14.82,;14.63,-15.51,;14.55,-17.04,;15.84,-17.89,;17.22,-17.18,;17.3,-15.65,;12.3,-10.9,;10.76,-10.9,;9.99,-12.24,;10.76,-13.56,;12.3,-13.56,;13.07,-12.24,;11.68,-14.82,;10.77,-16.08,;11.25,-17.54,;9.3,-15.6,;7.96,-16.37,;6.63,-15.6,;6.63,-14.05,;7.96,-13.28,;9.3,-14.05,)| Show InChI InChI=1S/C22H20N4O3/c27-20(24-19-9-13-26(25-19)16-4-2-1-3-5-16)15-6-10-22(11-7-15)18-14-23-12-8-17(18)21(28)29-22/h1-5,8-9,12-15H,6-7,10-11H2,(H,24,25,27)/t15-,22- | UniProtKB/SwissProt
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| n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of rat Y5 receptor |
Bioorg Med Chem 17: 6971-82 (2009)
Article DOI: 10.1016/j.bmc.2009.08.019
BindingDB Entry DOI: 10.7270/Q2P26Z62 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50304314
(CHEMBL596025 | trans-3-Oxo-N-(1-phenyl-1H-pyrazol-...)Show SMILES O=C(Nc1cnn(c1)-c1ccccc1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ccncc21 |r,wU:17.22,wD:14.15,(25.62,-7.99,;26.39,-9.32,;27.93,-9.32,;28.84,-10.57,;30.38,-10.57,;30.85,-12.03,;29.61,-12.94,;28.36,-12.03,;29.61,-14.47,;28.27,-15.24,;28.27,-16.77,;29.6,-17.55,;30.94,-16.77,;30.94,-15.23,;25.62,-10.65,;24.08,-10.65,;23.31,-11.99,;24.08,-13.32,;25.62,-13.32,;26.39,-11.99,;25,-14.57,;24.09,-15.83,;24.56,-17.29,;22.61,-15.35,;21.28,-16.12,;19.95,-15.35,;19.95,-13.81,;21.28,-13.03,;22.61,-13.8,)| Show InChI InChI=1S/C22H20N4O3/c27-20(25-16-12-24-26(14-16)17-4-2-1-3-5-17)15-6-9-22(10-7-15)19-13-23-11-8-18(19)21(28)29-22/h1-5,8,11-15H,6-7,9-10H2,(H,25,27)/t15-,22- | KEGG
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| n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human recombinant Y5 receptor |
Bioorg Med Chem 17: 6971-82 (2009)
Article DOI: 10.1016/j.bmc.2009.08.019
BindingDB Entry DOI: 10.7270/Q2P26Z62 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50304299
(CHEMBL595560 | trans-3-Oxo-N-(1-phenyl-1H-pyrazol-...)Show SMILES O=C(Nc1ccn(n1)-c1ccccc1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ccncc21 |r,wU:17.22,wD:14.15,(12.31,-8.24,;13.08,-9.57,;14.62,-9.57,;15.45,-10.87,;16.99,-10.95,;17.38,-12.44,;16.09,-13.28,;14.9,-12.31,;16.01,-14.82,;14.63,-15.51,;14.55,-17.04,;15.84,-17.89,;17.22,-17.18,;17.3,-15.65,;12.3,-10.9,;10.76,-10.9,;9.99,-12.24,;10.76,-13.56,;12.3,-13.56,;13.07,-12.24,;11.68,-14.82,;10.77,-16.08,;11.25,-17.54,;9.3,-15.6,;7.96,-16.37,;6.63,-15.6,;6.63,-14.05,;7.96,-13.28,;9.3,-14.05,)| Show InChI InChI=1S/C22H20N4O3/c27-20(24-19-9-13-26(25-19)16-4-2-1-3-5-16)15-6-10-22(11-7-15)18-14-23-12-8-17(18)21(28)29-22/h1-5,8-9,12-15H,6-7,10-11H2,(H,24,25,27)/t15-,22- | KEGG
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| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human recombinant Y5 receptor |
Bioorg Med Chem 17: 6971-82 (2009)
Article DOI: 10.1016/j.bmc.2009.08.019
BindingDB Entry DOI: 10.7270/Q2P26Z62 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50304318
(CHEMBL594888 | trans-3-Oxo-N-(5-phenylisoxazol-3-y...)Show SMILES O=C(Nc1cc(on1)-c1ccccc1)[C@H]1CC[C@@]2(CC1)OC(=O)c1cccnc21 |r,wU:17.22,wD:14.15,(-2.39,3.57,;-1.62,2.24,;-.08,2.23,;.84,1,;.38,-.47,;1.64,-1.36,;2.87,-.43,;2.37,1.02,;1.67,-2.89,;.34,-3.68,;.36,-5.22,;1.71,-5.97,;3.04,-5.17,;3.01,-3.63,;-2.4,.9,;-3.94,.9,;-4.71,-.43,;-3.94,-1.76,;-2.4,-1.76,;-1.63,-.43,;-3.02,-3.02,;-3.93,-4.27,;-3.45,-5.74,;-5.4,-3.79,;-6.74,-4.56,;-8.07,-3.79,;-8.07,-2.25,;-6.74,-1.48,;-5.4,-2.24,)| Show InChI InChI=1S/C22H19N3O4/c26-20(24-18-13-17(29-25-18)14-5-2-1-3-6-14)15-8-10-22(11-9-15)19-16(21(27)28-22)7-4-12-23-19/h1-7,12-13,15H,8-11H2,(H,24,25,26)/t15-,22- | KEGG
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| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human recombinant Y5 receptor |
Bioorg Med Chem 17: 6971-82 (2009)
Article DOI: 10.1016/j.bmc.2009.08.019
BindingDB Entry DOI: 10.7270/Q2P26Z62 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50304307
(CHEMBL595121 | trans-3-Oxo-N-(5-phenylpyrazin-2-yl...)Show SMILES O=C(Nc1cnc(cn1)-c1ccccc1)[C@H]1CC[C@@]2(CC1)OC(=O)c1cnccc21 |r,wU:18.23,wD:15.16,(10.15,-23,;10.91,-24.33,;12.45,-24.34,;13.29,-25.63,;12.58,-26.99,;13.42,-28.29,;14.96,-28.21,;15.66,-26.83,;14.82,-25.54,;15.8,-29.5,;15.09,-30.87,;15.93,-32.16,;17.47,-32.09,;18.17,-30.71,;17.33,-29.42,;10.14,-25.67,;8.6,-25.67,;7.83,-27,;8.6,-28.33,;10.14,-28.33,;10.91,-27,;9.52,-29.58,;8.61,-30.84,;9.09,-32.3,;7.13,-30.36,;5.8,-31.13,;4.47,-30.36,;4.47,-28.82,;5.8,-28.05,;7.13,-28.81,)| Show InChI InChI=1S/C23H20N4O3/c28-21(27-20-14-25-19(13-26-20)15-4-2-1-3-5-15)16-6-9-23(10-7-16)18-8-11-24-12-17(18)22(29)30-23/h1-5,8,11-14,16H,6-7,9-10H2,(H,26,27,28)/t16-,23- | KEGG
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PubMed
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human recombinant Y5 receptor |
Bioorg Med Chem 17: 6971-82 (2009)
Article DOI: 10.1016/j.bmc.2009.08.019
BindingDB Entry DOI: 10.7270/Q2P26Z62 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Rat 6B) | BDBM50304302
(3'-oxo-N-(5-phenylpyrazin-2-yl)-3'H-spiro[cyclohex...)Show SMILES O=C(Nc1cnc(cn1)-c1ccccc1)C1CCC2(CC1)OC(=O)c1ccccc21 Show InChI InChI=1S/C24H21N3O3/c28-22(27-21-15-25-20(14-26-21)16-6-2-1-3-7-16)17-10-12-24(13-11-17)19-9-5-4-8-18(19)23(29)30-24/h1-9,14-15,17H,10-13H2,(H,26,27,28) | UniProtKB/SwissProt
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| n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of rat Y5 receptor |
Bioorg Med Chem 17: 6971-82 (2009)
Article DOI: 10.1016/j.bmc.2009.08.019
BindingDB Entry DOI: 10.7270/Q2P26Z62 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50304311
(CHEMBL606631 | trans-3-Oxo-N-(3-phenyl-1H-pyrazol-...)Show SMILES O=C(Nc1cc(n[nH]1)-c1ccccc1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ccncc21 |r,wU:17.22,wD:14.15,(10.87,4.89,;11.64,3.56,;13.18,3.56,;14.01,2.26,;13.45,.83,;14.64,-.15,;15.94,.69,;15.54,2.18,;14.56,-1.68,;13.19,-2.38,;13.1,-3.91,;14.39,-4.75,;15.77,-4.05,;15.85,-2.52,;10.87,2.23,;9.33,2.23,;8.55,.89,;9.33,-.44,;10.87,-.44,;11.63,.89,;10.24,-1.69,;9.33,-2.95,;9.81,-4.41,;7.86,-2.47,;6.53,-3.24,;5.19,-2.47,;5.19,-.93,;6.52,-.15,;7.86,-.92,)| Show InChI InChI=1S/C22H20N4O3/c27-20(24-19-12-18(25-26-19)14-4-2-1-3-5-14)15-6-9-22(10-7-15)17-13-23-11-8-16(17)21(28)29-22/h1-5,8,11-13,15H,6-7,9-10H2,(H2,24,25,26,27)/t15-,22- | KEGG
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| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human recombinant Y5 receptor |
Bioorg Med Chem 17: 6971-82 (2009)
Article DOI: 10.1016/j.bmc.2009.08.019
BindingDB Entry DOI: 10.7270/Q2P26Z62 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50304305
(CHEMBL607192 | trans-3-Oxo-N-(5-phenylisoxazol-3-y...)Show SMILES O=C(Nc1cc(on1)-c1ccccc1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ncccc21 |r,wU:17.22,wD:14.15,(-4.45,-8.24,;-3.68,-9.57,;-2.14,-9.57,;-1.26,-10.84,;-1.77,-12.3,;-.55,-13.24,;.72,-12.36,;.28,-10.88,;-.58,-14.78,;-1.93,-15.51,;-1.97,-17.04,;-.65,-17.85,;.7,-17.1,;.73,-15.56,;-4.45,-10.9,;-5.99,-10.9,;-6.76,-12.24,;-5.99,-13.56,;-4.45,-13.56,;-3.68,-12.24,;-5.07,-14.82,;-5.98,-16.08,;-5.51,-17.54,;-7.46,-15.6,;-8.79,-16.37,;-10.12,-15.6,;-10.12,-14.05,;-8.79,-13.28,;-7.46,-14.05,)| Show InChI InChI=1S/C22H19N3O4/c26-20(24-18-13-17(29-25-18)14-5-2-1-3-6-14)15-8-10-22(11-9-15)16-7-4-12-23-19(16)21(27)28-22/h1-7,12-13,15H,8-11H2,(H,24,25,26)/t15-,22- | KEGG
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UniChem
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PubMed
| n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human recombinant Y5 receptor |
Bioorg Med Chem 17: 6971-82 (2009)
Article DOI: 10.1016/j.bmc.2009.08.019
BindingDB Entry DOI: 10.7270/Q2P26Z62 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50304308
(CHEMBL596266 | trans-3-Oxo-N-(3-phenyl-1H-pyrazol-...)Show SMILES O=C(Nc1cc(n[nH]1)-c1ccccc1)[C@H]1CC[C@@]2(CC1)OC(=O)c1cnccc21 |r,wU:17.22,wD:14.15,(-3.34,-34.45,;-2.57,-35.79,;-1.03,-35.79,;-.2,-37.09,;-.75,-38.53,;.44,-39.5,;1.74,-38.66,;1.34,-37.17,;.36,-41.03,;-1.01,-41.72,;-1.1,-43.26,;.19,-44.1,;1.57,-43.4,;1.65,-41.87,;-3.34,-37.12,;-4.88,-37.12,;-5.66,-38.46,;-4.88,-39.78,;-3.34,-39.78,;-2.58,-38.46,;-3.97,-41.04,;-4.88,-42.3,;-4.4,-43.76,;-6.35,-41.82,;-7.68,-42.59,;-9.02,-41.82,;-9.02,-40.27,;-7.69,-39.5,;-6.35,-40.27,)| Show InChI InChI=1S/C22H20N4O3/c27-20(24-19-12-18(25-26-19)14-4-2-1-3-5-14)15-6-9-22(10-7-15)17-8-11-23-13-16(17)21(28)29-22/h1-5,8,11-13,15H,6-7,9-10H2,(H2,24,25,26,27)/t15-,22- | KEGG
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PubMed
| n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human recombinant Y5 receptor |
Bioorg Med Chem 17: 6971-82 (2009)
Article DOI: 10.1016/j.bmc.2009.08.019
BindingDB Entry DOI: 10.7270/Q2P26Z62 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50301641
(CHEMBL585851 | trans-3-Oxo-N-(5-phenylpyrimidin-2-...)Show SMILES O=C(Nc1ncc(cn1)-c1ccccc1)[C@H]1CC[C@@]2(CC1)OC(=O)c1cccnc21 |r,wU:18.23,wD:15.16,(27.76,-36.84,;28.53,-38.18,;30.07,-38.18,;30.88,-39.49,;30.15,-40.84,;30.96,-42.15,;32.5,-42.1,;33.22,-40.74,;32.41,-39.43,;33.31,-43.4,;32.58,-44.76,;33.39,-46.07,;34.93,-46.02,;35.66,-44.65,;34.84,-43.35,;27.76,-39.51,;26.22,-39.51,;25.44,-40.84,;26.22,-42.17,;27.76,-42.17,;28.52,-40.84,;27.14,-43.43,;26.23,-44.68,;26.7,-46.15,;24.75,-44.21,;23.42,-44.98,;22.08,-44.21,;22.09,-42.66,;23.42,-41.89,;24.75,-42.65,)| Show InChI InChI=1S/C23H20N4O3/c28-20(27-22-25-13-17(14-26-22)15-5-2-1-3-6-15)16-8-10-23(11-9-16)19-18(21(29)30-23)7-4-12-24-19/h1-7,12-14,16H,8-11H2,(H,25,26,27,28)/t16-,23- | KEGG
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PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human recombinant Y5 receptor |
Bioorg Med Chem 17: 6971-82 (2009)
Article DOI: 10.1016/j.bmc.2009.08.019
BindingDB Entry DOI: 10.7270/Q2P26Z62 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50304317
(CHEMBL593466 | trans-3-Oxo-N-(5-phenylpyrazin-2-yl...)Show SMILES O=C(Nc1cnc(cn1)-c1ccccc1)[C@H]1CC[C@@]2(CC1)OC(=O)c1cccnc21 |r,wU:18.23,wD:15.16,(11.21,-36.61,;11.98,-37.94,;13.52,-37.95,;14.33,-39.26,;13.59,-40.61,;14.41,-41.92,;15.95,-41.87,;16.67,-40.5,;15.86,-39.2,;16.76,-43.17,;16.03,-44.53,;16.84,-45.84,;18.38,-45.79,;19.11,-44.42,;18.29,-43.12,;11.21,-39.28,;9.67,-39.28,;8.89,-40.61,;9.67,-41.94,;11.21,-41.94,;11.97,-40.61,;10.59,-43.2,;9.68,-44.45,;10.15,-45.92,;8.2,-43.97,;6.87,-44.74,;5.53,-43.97,;5.54,-42.43,;6.86,-41.66,;8.2,-42.42,)| Show InChI InChI=1S/C23H20N4O3/c28-21(27-19-14-25-18(13-26-19)15-5-2-1-3-6-15)16-8-10-23(11-9-16)20-17(22(29)30-23)7-4-12-24-20/h1-7,12-14,16H,8-11H2,(H,26,27,28)/t16-,23- | KEGG
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UniChem
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| Article
PubMed
| n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human recombinant Y5 receptor |
Bioorg Med Chem 17: 6971-82 (2009)
Article DOI: 10.1016/j.bmc.2009.08.019
BindingDB Entry DOI: 10.7270/Q2P26Z62 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50304304
(CHEMBL596031 | trans-3-Oxo-N-(5-phenylpyrazin-2-yl...)Show SMILES O=C(Nc1cnc(cn1)-c1ccccc1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ncccc21 |r,wU:18.23,wD:15.16,(11.32,4.93,;12.09,3.6,;13.63,3.6,;14.4,2.26,;13.62,.93,;14.39,-.4,;15.93,-.41,;16.7,.94,;15.93,2.26,;16.7,-1.73,;15.93,-3.07,;16.69,-4.4,;18.24,-4.4,;19.01,-3.06,;18.23,-1.73,;11.32,2.26,;9.78,2.26,;9,.93,;9.78,-.4,;11.32,-.4,;12.08,.93,;10.7,-1.65,;9.78,-2.91,;10.26,-4.37,;8.31,-2.43,;6.98,-3.2,;5.64,-2.43,;5.64,-.89,;6.97,-.12,;8.31,-.88,)| Show InChI InChI=1S/C23H20N4O3/c28-21(27-19-14-25-18(13-26-19)15-5-2-1-3-6-15)16-8-10-23(11-9-16)17-7-4-12-24-20(17)22(29)30-23/h1-7,12-14,16H,8-11H2,(H,26,27,28)/t16-,23- | KEGG
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UniChem
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| Article
PubMed
| n/a | n/a | 4.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human recombinant Y5 receptor |
Bioorg Med Chem 17: 6971-82 (2009)
Article DOI: 10.1016/j.bmc.2009.08.019
BindingDB Entry DOI: 10.7270/Q2P26Z62 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50304297
(CHEMBL594163 | trans-3-Oxo-N-(1-phenyl-1H-pyrazol-...)Show SMILES O=C(Nc1ccn(n1)-c1ccccc1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ncccc21 |r,wU:17.22,wD:14.15,(24.81,-8.6,;25.58,-9.94,;27.12,-9.94,;28,-11.21,;29.55,-11.24,;29.99,-12.71,;28.72,-13.59,;27.5,-12.65,;28.69,-15.12,;27.34,-15.86,;27.3,-17.4,;28.62,-18.2,;29.97,-17.45,;30,-15.91,;24.81,-11.27,;23.27,-11.27,;22.5,-12.6,;23.27,-13.93,;24.81,-13.93,;25.58,-12.6,;24.19,-15.19,;23.28,-16.44,;23.75,-17.91,;21.8,-15.96,;20.47,-16.74,;19.14,-15.96,;19.14,-14.42,;20.47,-13.65,;21.8,-14.41,)| Show InChI InChI=1S/C22H20N4O3/c27-20(24-18-10-14-26(25-18)16-5-2-1-3-6-16)15-8-11-22(12-9-15)17-7-4-13-23-19(17)21(28)29-22/h1-7,10,13-15H,8-9,11-12H2,(H,24,25,27)/t15-,22- | KEGG
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PubMed
| n/a | n/a | 4.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human recombinant Y5 receptor |
Bioorg Med Chem 17: 6971-82 (2009)
Article DOI: 10.1016/j.bmc.2009.08.019
BindingDB Entry DOI: 10.7270/Q2P26Z62 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Rat 6B) | BDBM50304298
(CHEMBL595120 | trans-3-Oxo-N-(1-phenyl-1H-pyrazol-...)Show SMILES O=C(Nc1cnn(c1)-c1ccccc1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ncccc21 |r,wU:17.22,wD:14.15,(-4.96,-20.66,;-4.19,-21.99,;-2.65,-21.99,;-1.77,-23.26,;-.23,-23.29,;.22,-24.77,;-1.05,-25.64,;-2.28,-24.71,;-1.08,-27.17,;-2.44,-27.91,;-2.47,-29.45,;-1.16,-30.25,;.2,-29.51,;.23,-27.97,;-4.96,-23.32,;-6.5,-23.32,;-7.28,-24.66,;-6.5,-25.99,;-4.96,-25.99,;-4.2,-24.66,;-5.58,-27.24,;-6.49,-28.5,;-6.02,-29.96,;-7.97,-28.02,;-9.3,-28.79,;-10.64,-28.02,;-10.63,-26.48,;-9.31,-25.7,;-7.97,-26.47,)| Show InChI InChI=1S/C22H20N4O3/c27-20(25-16-13-24-26(14-16)17-5-2-1-3-6-17)15-8-10-22(11-9-15)18-7-4-12-23-19(18)21(28)29-22/h1-7,12-15H,8-11H2,(H,25,27)/t15-,22- | UniProtKB/SwissProt
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| n/a | n/a | 4.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of rat Y5 receptor |
Bioorg Med Chem 17: 6971-82 (2009)
Article DOI: 10.1016/j.bmc.2009.08.019
BindingDB Entry DOI: 10.7270/Q2P26Z62 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50304306
(CHEMBL607088 | trans-3-Oxo-N-(3-phenyl-1H-pyrazol-...)Show SMILES O=C(Nc1cc(n[nH]1)-c1ccccc1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ncccc21 |r,wU:17.22,wD:14.15,(10.49,-8.76,;11.26,-10.1,;12.8,-10.1,;13.67,-11.37,;13.16,-12.83,;14.39,-13.76,;15.65,-12.89,;15.21,-11.41,;14.35,-15.3,;13,-16.03,;12.96,-17.57,;14.28,-18.38,;15.64,-17.63,;15.67,-16.09,;10.48,-11.43,;8.94,-11.43,;8.17,-12.77,;8.94,-14.09,;10.48,-14.09,;11.25,-12.77,;9.86,-15.35,;8.95,-16.61,;9.43,-18.07,;7.48,-16.13,;6.14,-16.9,;4.81,-16.13,;4.81,-14.58,;6.14,-13.81,;7.48,-14.58,)| Show InChI InChI=1S/C22H20N4O3/c27-20(24-18-13-17(25-26-18)14-5-2-1-3-6-14)15-8-10-22(11-9-15)16-7-4-12-23-19(16)21(28)29-22/h1-7,12-13,15H,8-11H2,(H2,24,25,26,27)/t15-,22- | KEGG
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| CHEMBL
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UniChem
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| Article
PubMed
| n/a | n/a | 5.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human recombinant Y5 receptor |
Bioorg Med Chem 17: 6971-82 (2009)
Article DOI: 10.1016/j.bmc.2009.08.019
BindingDB Entry DOI: 10.7270/Q2P26Z62 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50304319
(CHEMBL593935 | trans-3-Oxo-N-(3-phenyl-1H-pyrazol-...)Show SMILES O=C(Nc1cc(n[nH]1)-c1ccccc1)[C@H]1CC[C@@]2(CC1)OC(=O)c1cccnc21 |r,wU:17.22,wD:14.15,(17.04,3.61,;17.81,2.27,;19.35,2.27,;20.28,1.04,;19.82,-.43,;21.08,-1.32,;22.31,-.39,;21.81,1.06,;21.1,-2.85,;19.78,-3.64,;19.8,-5.18,;21.15,-5.93,;22.47,-5.13,;22.44,-3.59,;17.04,.94,;15.5,.94,;14.73,-.39,;15.5,-1.72,;17.04,-1.72,;17.81,-.39,;16.42,-2.98,;15.51,-4.23,;15.98,-5.7,;14.03,-3.75,;12.7,-4.52,;11.37,-3.75,;11.37,-2.21,;12.7,-1.44,;14.03,-2.2,)| Show InChI InChI=1S/C22H20N4O3/c27-20(24-18-13-17(25-26-18)14-5-2-1-3-6-14)15-8-10-22(11-9-15)19-16(21(28)29-22)7-4-12-23-19/h1-7,12-13,15H,8-11H2,(H2,24,25,26,27)/t15-,22- | KEGG
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| CHEMBL
PC cid
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UniChem
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| Article
PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human recombinant Y5 receptor |
Bioorg Med Chem 17: 6971-82 (2009)
Article DOI: 10.1016/j.bmc.2009.08.019
BindingDB Entry DOI: 10.7270/Q2P26Z62 |
More data for this
Ligand-Target Pair | |
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