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USPatent US9790201

Compile data set for download or QSAR
Found 119 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347545
PNG
(4-{[3-(4-Chloro-2-methylphenyl)piperidin-1-yl]carb...)
Show SMILES CNc1cc(ccn1)C(=O)N1CCCC(C1)c1ccc(Cl)cc1C
Show InChI InChI=1S/C19H22ClN3O/c1-13-10-16(20)5-6-17(13)15-4-3-9-23(12-15)19(24)14-7-8-22-18(11-14)21-2/h5-8,10-11,15H,3-4,9,12H2,1-2H3,(H,21,22)
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n/an/a 30n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347538
PNG
(4-{[3-(4-Chloro-2-methylphenyl)piperidin-1-yl]carb...)
Show SMILES CN(C)c1cc(ccn1)C(=O)N1CCCC(C1)c1ccc(Cl)cc1C
Show InChI InChI=1S/C20H24ClN3O/c1-14-11-17(21)6-7-18(14)16-5-4-10-24(13-16)20(25)15-8-9-22-19(12-15)23(2)3/h6-9,11-12,16H,4-5,10,13H2,1-3H3
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347585
PNG
(5-{[3-(4-Chloro-2-methylphenyl)piperidin-1-yl]carb...)
Show SMILES CNc1cc(cnn1)C(=O)N1CCCC(C1)c1ccc(Cl)cc1C
Show InChI InChI=1S/C18H21ClN4O/c1-12-8-15(19)5-6-16(12)13-4-3-7-23(11-13)18(24)14-9-17(20-2)22-21-10-14/h5-6,8-10,13H,3-4,7,11H2,1-2H3,(H,20,22)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347577
PNG
(4-{[3-(4-Methoxy-2-methylphenyl)piperidin-1-yl]car...)
Show SMILES CNc1cc(ccn1)C(=O)N1CCCC(C1)c1ccc(OC)cc1C
Show InChI InChI=1S/C20H25N3O2/c1-14-11-17(25-3)6-7-18(14)16-5-4-10-23(13-16)20(24)15-8-9-22-19(12-15)21-2/h6-9,11-12,16H,4-5,10,13H2,1-3H3,(H,21,22)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347578
PNG
(4-({3-[4-Methoxy-2-(trifluoromethyl)phenyl]piperid...)
Show SMILES CNc1cc(ccn1)C(=O)N1CCCC(C1)c1ccc(OC)cc1C(F)(F)F
Show InChI InChI=1S/C20H22F3N3O2/c1-24-18-10-13(7-8-25-18)19(27)26-9-3-4-14(12-26)16-6-5-15(28-2)11-17(16)20(21,22)23/h5-8,10-11,14H,3-4,9,12H2,1-2H3,(H,24,25)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347571
PNG
(4-({3-[4-Chloro-2-(trifluoromethyl)phenyl]piperidi...)
Show SMILES CNc1cc(ccn1)C(=O)N1CCCC(C1)c1ccc(Cl)cc1C(F)(F)F
Show InChI InChI=1S/C19H19ClF3N3O/c1-24-17-9-12(6-7-25-17)18(27)26-8-2-3-13(11-26)15-5-4-14(20)10-16(15)19(21,22)23/h4-7,9-10,13H,2-3,8,11H2,1H3,(H,24,25)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347518
PNG
(3-Chloro-5-{[3-(4-chloro-2-methylphenyl)piperidin-...)
Show SMILES CCc1cc(ccn1)C(=O)N1CCCC(C1)c1ccc(Cl)cc1C
Show InChI InChI=1S/C20H23ClN2O/c1-3-18-12-15(8-9-22-18)20(24)23-10-4-5-16(13-23)19-7-6-17(21)11-14(19)2/h6-9,11-12,16H,3-5,10,13H2,1-2H3
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347579
PNG
(4-{[3-(4-Chloro-2-ethoxyphenyl)piperidin-1-yl]carb...)
Show SMILES CCOc1cc(Cl)ccc1C1CCCN(C1)C(=O)c1ccnc(NC)c1
Show InChI InChI=1S/C20H24ClN3O2/c1-3-26-18-12-16(21)6-7-17(18)15-5-4-10-24(13-15)20(25)14-8-9-23-19(11-14)22-2/h6-9,11-12,15H,3-5,10,13H2,1-2H3,(H,22,23)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347585
PNG
(5-{[3-(4-Chloro-2-methylphenyl)piperidin-1-yl]carb...)
Show SMILES CNc1cc(cnn1)C(=O)N1CCCC(C1)c1ccc(Cl)cc1C
Show InChI InChI=1S/C18H21ClN4O/c1-12-8-15(19)5-6-16(12)13-4-3-7-23(11-13)18(24)14-9-17(20-2)22-21-10-14/h5-6,8-10,13H,3-4,7,11H2,1-2H3,(H,20,22)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347591
PNG
(5-({3-[4-Chloro-2-(trifluoromethyl)phenyl]piperidi...)
Show SMILES CNc1cc(cnn1)C(=O)N1CCCC(C1)c1ccc(Cl)cc1C(F)(F)F
Show InChI InChI=1S/C18H18ClF3N4O/c1-23-16-7-12(9-24-25-16)17(27)26-6-2-3-11(10-26)14-5-4-13(19)8-15(14)18(20,21)22/h4-5,7-9,11H,2-3,6,10H2,1H3,(H,23,25)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347547
PNG
(2-(Azetidin-1-yl)-4-{[3-(4-chloro-2-methylphenyl)p...)
Show SMILES Cc1cc(Cl)ccc1C1CCCN(C1)C(=O)c1ccnc(c1)N1CCC1
Show InChI InChI=1S/C21H24ClN3O/c1-15-12-18(22)5-6-19(15)17-4-2-9-25(14-17)21(26)16-7-8-23-20(13-16)24-10-3-11-24/h5-8,12-13,17H,2-4,9-11,14H2,1H3
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347599
PNG
(5-{[3-(4-Chloro-2-ethoxyphenyl)piperidin-1-yl]carb...)
Show SMILES CCOc1cc(Cl)ccc1C1CCCN(C1)C(=O)c1cnnc(c1)N(C)C
Show InChI InChI=1S/C20H25ClN4O2/c1-4-27-18-11-16(21)7-8-17(18)14-6-5-9-25(13-14)20(26)15-10-19(24(2)3)23-22-12-15/h7-8,10-12,14H,4-6,9,13H2,1-3H3
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347575
PNG
(4-{[3-(4-Chloro-2-ethoxyphenyl)piperidin-1-yl]carb...)
Show SMILES CCOc1cc(Cl)ccc1C1CCCN(C1)C(=O)c1ccnc(c1)N(C)C
Show InChI InChI=1S/C21H26ClN3O2/c1-4-27-19-13-17(22)7-8-18(19)16-6-5-11-25(14-16)21(26)15-9-10-23-20(12-15)24(2)3/h7-10,12-13,16H,4-6,11,14H2,1-3H3
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347612
PNG
(3-[4-Chloro-2-(trifluoromethyl)phenyl]-1-[(1-methy...)
Show SMILES Cn1cc(cn1)C(=O)N1CCCC(C1)c1ccc(Cl)cc1C(F)(F)F
Show InChI InChI=1S/C17H17ClF3N3O/c1-23-9-12(8-22-23)16(25)24-6-2-3-11(10-24)14-5-4-13(18)7-15(14)17(19,20)21/h4-5,7-9,11H,2-3,6,10H2,1H3
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347576
PNG
(4-({3-[4-Methoxy-2-(trifluoromethyl)phenyl]piperid...)
Show SMILES COc1ccc(C2CCCN(C2)C(=O)c2ccnc(c2)N(C)C)c(c1)C(F)(F)F
Show InChI InChI=1S/C21H24F3N3O2/c1-26(2)19-11-14(8-9-25-19)20(28)27-10-4-5-15(13-27)17-7-6-16(29-3)12-18(17)21(22,23)24/h6-9,11-12,15H,4-5,10,13H2,1-3H3
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347521
PNG
(3-Chloro-5-{[3-(4-methoxy-2-methylphenyl)piperidin...)
Show SMILES CN(C)c1cc(ccn1)C(=O)N1CCCC(C1)c1ccc(Cl)cc1C(F)(F)F
Show InChI InChI=1S/C20H21ClF3N3O/c1-26(2)18-10-13(7-8-25-18)19(28)27-9-3-4-14(12-27)16-6-5-15(21)11-17(16)20(22,23)24/h5-8,10-11,14H,3-4,9,12H2,1-2H3
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347590
PNG
(5-({3-[4-Chloro-2-(trifluoromethyl)phenyl]piperidi...)
Show SMILES CN(C)c1cc(cnn1)C(=O)N1CCCC(C1)c1ccc(Cl)cc1C(F)(F)F
Show InChI InChI=1S/C19H20ClF3N4O/c1-26(2)17-8-13(10-24-25-17)18(28)27-7-3-4-12(11-27)15-6-5-14(20)9-16(15)19(21,22)23/h5-6,8-10,12H,3-4,7,11H2,1-2H3
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347607
PNG
(3-(4-Chloro-2-methylphenyl)-1-[(1-ethyl-1H-pyrazol...)
Show SMILES CCn1cc(cn1)C(=O)N1CCCC(C1)c1ccc(Cl)cc1C
Show InChI InChI=1S/C18H22ClN3O/c1-3-22-12-15(10-20-22)18(23)21-8-4-5-14(11-21)17-7-6-16(19)9-13(17)2/h6-7,9-10,12,14H,3-5,8,11H2,1-2H3
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347584
PNG
(5-{[3-(4-Chloro-2-methylphenyl)piperidin-1-yl]carb...)
Show SMILES CN(C)c1cc(cnn1)C(=O)N1CCCC(C1)c1ccc(Cl)cc1C
Show InChI InChI=1S/C19H23ClN4O/c1-13-9-16(20)6-7-17(13)14-5-4-8-24(12-14)19(25)15-10-18(23(2)3)22-21-11-15/h6-7,9-11,14H,4-5,8,12H2,1-3H3
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347596
PNG
(5-({3-[4-Methoxy-2-(trifluoromethyl)phenyl]piperid...)
Show SMILES CNc1cc(cnn1)C(=O)N1CCCC(C1)c1ccc(OC)cc1C(F)(F)F
Show InChI InChI=1S/C19H21F3N4O2/c1-23-17-8-13(10-24-25-17)18(27)26-7-3-4-12(11-26)15-6-5-14(28-2)9-16(15)19(20,21)22/h5-6,8-10,12H,3-4,7,11H2,1-2H3,(H,23,25)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347541
PNG
(4-{[3-(4-Chlorophenyl)piperidin-1-yl]carbonyl}-N-m...)
Show SMILES CNc1cc(ccn1)C(=O)N1CCCC(C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C18H20ClN3O/c1-20-17-11-14(8-9-21-17)18(23)22-10-2-3-15(12-22)13-4-6-16(19)7-5-13/h4-9,11,15H,2-3,10,12H2,1H3,(H,20,21)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347594
PNG
(5-{[3-(4-Methoxy-2-methylphenyl)piperidin-1-yl]car...)
Show SMILES CNc1cc(cnn1)C(=O)N1CCCC(C1)c1ccc(OC)cc1C
Show InChI InChI=1S/C19H24N4O2/c1-13-9-16(25-3)6-7-17(13)14-5-4-8-23(12-14)19(24)15-10-18(20-2)22-21-11-15/h6-7,9-11,14H,4-5,8,12H2,1-3H3,(H,20,22)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347610
PNG
(4-{[3-(4-Chloro-2-methylphenyl)piperidin-1-yl]carb...)
Show SMILES Cc1cc(Cl)ccc1C1CCCN(C1)C(=O)c1cnn(C)c1N
Show InChI InChI=1S/C17H21ClN4O/c1-11-8-13(18)5-6-14(11)12-4-3-7-22(10-12)17(23)15-9-20-21(2)16(15)19/h5-6,8-9,12H,3-4,7,10,19H2,1-2H3
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347595
PNG
(5-{[3-(4-Methoxy-2-methylphenyl)piperidin-1-yl]car...)
Show SMILES COc1ccc(C2CCCN(C2)C(=O)c2cnnc(c2)N(C)C)c(C)c1
Show InChI InChI=1S/C20H26N4O2/c1-14-10-17(26-4)7-8-18(14)15-6-5-9-24(13-15)20(25)16-11-19(23(2)3)22-21-12-16/h7-8,10-12,15H,5-6,9,13H2,1-4H3
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347613
PNG
(3-[4-Chloro-2-(trifluoromethyl)phenyl]-1-[(1-ethyl...)
Show SMILES CCn1cc(cn1)C(=O)N1CCCC(C1)c1ccc(Cl)cc1C(F)(F)F
Show InChI InChI=1S/C18H19ClF3N3O/c1-2-25-11-13(9-23-25)17(26)24-7-3-4-12(10-24)15-6-5-14(19)8-16(15)18(20,21)22/h5-6,8-9,11-12H,2-4,7,10H2,1H3
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347598
PNG
(5-{[3-(4-Chloro-2-ethoxyphenyl)piperidin-1-yl]carb...)
Show SMILES CCOc1cc(Cl)ccc1C1CCCN(C1)C(=O)c1cnnc(NC)c1
Show InChI InChI=1S/C19H23ClN4O2/c1-3-26-17-10-15(20)6-7-16(17)13-5-4-8-24(12-13)19(25)14-9-18(21-2)23-22-11-14/h6-7,9-11,13H,3-5,8,12H2,1-2H3,(H,21,23)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347609
PNG
(3-(4-Chloro-2-methylphenyl)-1-[(1-methyl-1H-pyrazo...)
Show SMILES Cc1cc(Cl)ccc1C1CCCN(C1)C(=O)c1cnn(C)c1
Show InChI InChI=1S/C17H20ClN3O/c1-12-8-15(18)5-6-16(12)13-4-3-7-21(11-13)17(22)14-9-19-20(2)10-14/h5-6,8-10,13H,3-4,7,11H2,1-2H3
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347608
PNG
(3-(4-Chloro-2-methylphenyl)-1-{[1-(propan-2-yl)-1H...)
Show SMILES CC(C)n1cc(cn1)C(=O)N1CCCC(C1)c1ccc(Cl)cc1C
Show InChI InChI=1S/C19H24ClN3O/c1-13(2)23-12-16(10-21-23)19(24)22-8-4-5-15(11-22)18-7-6-17(20)9-14(18)3/h6-7,9-10,12-13,15H,4-5,8,11H2,1-3H3
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347532
PNG
(4-{[(3R)-3-(4-Chlorophenyl)piperidin-1-yl]carbonyl...)
Show SMILES CN(C)c1cc(ccn1)C(=O)N1CCC[C@@H](C1)c1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C19H22ClN3O/c1-22(2)18-12-15(9-10-21-18)19(24)23-11-3-4-16(13-23)14-5-7-17(20)8-6-14/h5-10,12,16H,3-4,11,13H2,1-2H3/t16-/m0/s1
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347516
PNG
(4-{[3-(2,4-Dichlorophenyl)piperidin-1-yl]carbonyl}...)
Show SMILES CN(C)c1cc(ccn1)C(=O)N1CCCC(C1)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C19H21Cl2N3O/c1-23(2)18-10-13(7-8-22-18)19(25)24-9-3-4-14(12-24)16-6-5-15(20)11-17(16)21/h5-8,10-11,14H,3-4,9,12H2,1-2H3
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347528
PNG
(N,N-Dimethyl-4-{[3-(2-methylphenyl)piperidin-1-yl]...)
Show SMILES CN(C)c1cc(ccn1)C(=O)N1CCCC(C1)c1ccccc1C
Show InChI InChI=1S/C20H25N3O/c1-15-7-4-5-9-18(15)17-8-6-12-23(14-17)20(24)16-10-11-21-19(13-16)22(2)3/h4-5,7,9-11,13,17H,6,8,12,14H2,1-3H3
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347602
PNG
(3-(4-Chloro-2-methylphenyl)-1-[(1,3-dimethyl-1H-py...)
Show SMILES Cc1nn(C)cc1C(=O)N1CCCC(C1)c1ccc(Cl)cc1C
Show InChI InChI=1S/C18H22ClN3O/c1-12-9-15(19)6-7-16(12)14-5-4-8-22(10-14)18(23)17-11-21(3)20-13(17)2/h6-7,9,11,14H,4-5,8,10H2,1-3H3
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347597
PNG
(5-({3-[4-Methoxy-2-(trifluoromethyl)phenyl]piperid...)
Show SMILES COc1ccc(C2CCCN(C2)C(=O)c2cnnc(c2)N(C)C)c(c1)C(F)(F)F
Show InChI InChI=1S/C20H23F3N4O2/c1-26(2)18-9-14(11-24-25-18)19(28)27-8-4-5-13(12-27)16-7-6-15(29-3)10-17(16)20(21,22)23/h6-7,9-11,13H,4-5,8,12H2,1-3H3
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347559
PNG
(N,N-Dimethyl-4-({3-[2-(trifluoromethyl)phenyl]pipe...)
Show SMILES CN(C)c1cc(ccn1)C(=O)N1CCCC(C1)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C20H22F3N3O/c1-25(2)18-12-14(9-10-24-18)19(27)26-11-5-6-15(13-26)16-7-3-4-8-17(16)20(21,22)23/h3-4,7-10,12,15H,5-6,11,13H2,1-2H3
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347568
PNG
(N-Methyl-4-({3-[2-(trifluoromethyl)phenyl]piperidi...)
Show SMILES CNc1cc(ccn1)C(=O)N1CCCC(C1)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C19H20F3N3O/c1-23-17-11-13(8-9-24-17)18(26)25-10-4-5-14(12-25)15-6-2-3-7-16(15)19(20,21)22/h2-3,6-9,11,14H,4-5,10,12H2,1H3,(H,23,24)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347530
PNG
(4-{[3-(4-Chlorophenyl)piperidin-1-yl]carbonyl}-N,N...)
Show SMILES CN(C)c1cc(ccn1)C(=O)N1CCCC(C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H22ClN3O/c1-22(2)18-12-15(9-10-21-18)19(24)23-11-3-4-16(13-23)14-5-7-17(20)8-6-14/h5-10,12,16H,3-4,11,13H2,1-2H3
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347620
PNG
(4-{[5-(4-Chloro-2-methylphenyl)-1,2,3,4-tetrahydro...)
Show SMILES CN(C)c1cc(ccn1)C(=O)N1CCCC(=C1)c1ccc(Cl)cc1C |c:16|
Show InChI InChI=1S/C20H22ClN3O/c1-14-11-17(21)6-7-18(14)16-5-4-10-24(13-16)20(25)15-8-9-22-19(12-15)23(2)3/h6-9,11-13H,4-5,10H2,1-3H3
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347520
PNG
(4-({3-[4-Chloro-2-(trifluoromethyl)phenyl]piperidi...)
Show SMILES CCc1cc(ccn1)C(=O)N1CCCC(C1)c1ccc(Cl)cc1C(F)(F)F
Show InChI InChI=1S/C20H20ClF3N2O/c1-2-16-10-13(7-8-25-16)19(27)26-9-3-4-14(12-26)17-6-5-15(21)11-18(17)20(22,23)24/h5-8,10-11,14H,2-4,9,12H2,1H3
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347525
PNG
(3-Chloro-5-{[3-(2-methoxyphenyl)piperidin-1-yl]car...)
Show SMILES CN(C)c1cc(ccn1)C(=O)N1CCCC(C1)c1ccc(C)cc1
Show InChI InChI=1S/C20H25N3O/c1-15-6-8-16(9-7-15)18-5-4-12-23(14-18)20(24)17-10-11-21-19(13-17)22(2)3/h6-11,13,18H,4-5,12,14H2,1-3H3
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347525
PNG
(3-Chloro-5-{[3-(2-methoxyphenyl)piperidin-1-yl]car...)
Show SMILES CN(C)c1cc(ccn1)C(=O)N1CCCC(C1)c1ccc(C)cc1
Show InChI InChI=1S/C20H25N3O/c1-15-6-8-16(9-7-15)18-5-4-12-23(14-18)20(24)17-10-11-21-19(13-17)22(2)3/h6-11,13,18H,4-5,12,14H2,1-3H3
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347614
PNG
(3-[4-Chloro-2-(trifluoromethyl)phenyl]-1-{[1-(prop...)
Show SMILES CC(C)n1cc(cn1)C(=O)N1CCCC(C1)c1ccc(Cl)cc1C(F)(F)F
Show InChI InChI=1S/C19H21ClF3N3O/c1-12(2)26-11-14(9-24-26)18(27)25-7-3-4-13(10-25)16-6-5-15(20)8-17(16)19(21,22)23/h5-6,8-9,11-13H,3-4,7,10H2,1-2H3
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n/an/a 330n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347615
PNG
(4-({3-[4-Chloro-2-(trifluoromethyl)phenyl]piperidi...)
Show SMILES Cn1cc(C(=O)N2CCCC(C2)c2ccc(Cl)cc2C(F)(F)F)c(N)n1
Show InChI InChI=1S/C17H18ClF3N4O/c1-24-9-13(15(22)23-24)16(26)25-6-2-3-10(8-25)12-5-4-11(18)7-14(12)17(19,20)21/h4-5,7,9-10H,2-3,6,8H2,1H3,(H2,22,23)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347569
PNG
(4-{[3-(4-Methoxyphenyl)piperidin-1-yl]carbonyl}-N-...)
Show SMILES CNc1cc(ccn1)C(=O)N1CCCC(C1)c1ccc(OC)cc1
Show InChI InChI=1S/C19H23N3O2/c1-20-18-12-15(9-10-21-18)19(23)22-11-3-4-16(13-22)14-5-7-17(24-2)8-6-14/h5-10,12,16H,3-4,11,13H2,1-2H3,(H,20,21)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347589
PNG
(5-{[3-(4-Chloro-2-methylphenyl)piperidin-1-yl]carb...)
Show SMILES COc1cc(cnn1)C(=O)N1CCCC(C1)c1ccc(Cl)cc1C
Show InChI InChI=1S/C18H20ClN3O2/c1-12-8-15(19)5-6-16(12)13-4-3-7-22(11-13)18(23)14-9-17(24-2)21-20-10-14/h5-6,8-10,13H,3-4,7,11H2,1-2H3
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347562
PNG
(4-{[3-(2-Methoxyphenyl)piperidin-1-yl]carbonyl}-N,...)
Show SMILES COc1ccccc1C1CCCN(C1)C(=O)c1ccnc(c1)N(C)C
Show InChI InChI=1S/C20H25N3O2/c1-22(2)19-13-15(10-11-21-19)20(24)23-12-6-7-16(14-23)17-8-4-5-9-18(17)25-3/h4-5,8-11,13,16H,6-7,12,14H2,1-3H3
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347525
PNG
(3-Chloro-5-{[3-(2-methoxyphenyl)piperidin-1-yl]car...)
Show SMILES CN(C)c1cc(ccn1)C(=O)N1CCCC(C1)c1ccc(C)cc1
Show InChI InChI=1S/C20H25N3O/c1-15-6-8-16(9-7-15)18-5-4-12-23(14-18)20(24)17-10-11-21-19(13-17)22(2)3/h6-11,13,18H,4-5,12,14H2,1-3H3
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347619
PNG
(4-{[5-(4-Chlorophenyl)-1,2,3,4-tetrahydropyridin-1...)
Show SMILES CN(C)c1cc(ccn1)C(=O)N1CCCC(=C1)c1ccc(Cl)cc1 |c:16|
Show InChI InChI=1S/C19H20ClN3O/c1-22(2)18-12-15(9-10-21-18)19(24)23-11-3-4-16(13-23)14-5-7-17(20)8-6-14/h5-10,12-13H,3-4,11H2,1-2H3
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347626
PNG
(4-{[3-(4-Chlorophenyl)azepan-1-yl]carbonyl}-N-meth...)
Show SMILES CNc1cc(ccn1)C(=O)N1CCCCC(C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H22ClN3O/c1-21-18-12-15(9-10-22-18)19(24)23-11-3-2-4-16(13-23)14-5-7-17(20)8-6-14/h5-10,12,16H,2-4,11,13H2,1H3,(H,21,22)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347570
PNG
(4-{[3-(2-Methoxyphenyl)piperidin-1-yl]carbonyl}-N-...)
Show SMILES CNc1cc(ccn1)C(=O)N1CCCC(C1)c1ccccc1OC
Show InChI InChI=1S/C19H23N3O2/c1-20-18-12-14(9-10-21-18)19(23)22-11-5-6-15(13-22)16-7-3-4-8-17(16)24-2/h3-4,7-10,12,15H,5-6,11,13H2,1-2H3,(H,20,21)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347625
PNG
(4-{[3-(4-Methoxyphenyl)azepan-1-yl]carbonyl}-N-met...)
Show SMILES CNc1cc(ccn1)C(=O)N1CCCCC(C1)c1ccc(OC)cc1
Show InChI InChI=1S/C20H25N3O2/c1-21-19-13-16(10-11-22-19)20(24)23-12-4-3-5-17(14-23)15-6-8-18(25-2)9-7-15/h6-11,13,17H,3-5,12,14H2,1-2H3,(H,21,22)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347519
PNG
(4-{[3-(4-Chloro-2-methylphenyl)piperidin-1-yl]carb...)
Show SMILES Cc1cc(ccn1)C(=O)N1CCCC(C1)c1ccc(Cl)cc1C
Show InChI InChI=1S/C19H21ClN2O/c1-13-10-17(20)5-6-18(13)16-4-3-9-22(12-16)19(23)15-7-8-21-14(2)11-15/h5-8,10-11,16H,3-4,9,12H2,1-2H3
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347561
PNG
(4-{[3-(4-Methoxyphenyl)piperidin-1-yl]carbonyl}-N,...)
Show SMILES COc1ccc(cc1)C1CCCN(C1)C(=O)c1ccnc(c1)N(C)C
Show InChI InChI=1S/C20H25N3O2/c1-22(2)19-13-16(10-11-21-19)20(24)23-12-4-5-17(14-23)15-6-8-18(25-3)9-7-15/h6-11,13,17H,4-5,12,14H2,1-3H3
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347540
PNG
(4-{[3-(2-Chloro-4-fluorophenyl)piperidin-1-yl]carb...)
Show SMILES CN(C)c1cc(ccn1)C(=O)N1CCCC(C1)c1ccc(F)cc1Cl
Show InChI InChI=1S/C19H21ClFN3O/c1-23(2)18-10-13(7-8-22-18)19(25)24-9-3-4-14(12-24)16-6-5-15(21)11-17(16)20/h5-8,10-11,14H,3-4,9,12H2,1-2H3
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347546
PNG
(4-{[3-(4-Chloro-2-methylphenyl)piperidin-1-yl]carb...)
Show SMILES COc1cc(ccn1)C(=O)N1CCCC(C1)c1ccc(Cl)cc1C
Show InChI InChI=1S/C19H21ClN2O2/c1-13-10-16(20)5-6-17(13)15-4-3-9-22(12-15)19(23)14-7-8-21-18(11-14)24-2/h5-8,10-11,15H,3-4,9,12H2,1-2H3
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347618
PNG
(3-[4-Chloro-2-(trifluoromethyl)phenyl]-1-[(1,3-dim...)
Show SMILES Cc1nn(C)cc1C(=O)N1CCCC(C1)c1ccc(Cl)cc1C(F)(F)F
Show InChI InChI=1S/C18H19ClF3N3O/c1-11-15(10-24(2)23-11)17(26)25-7-3-4-12(9-25)14-6-5-13(19)8-16(14)18(20,21)22/h5-6,8,10,12H,3-4,7,9H2,1-2H3
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347566
PNG
(4-{[3-(4-Chlorophenyl)piperidin-1-yl]carbonyl}-2-e...)
Show SMILES CCc1cc(ccn1)C(=O)N1CCCC(C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H21ClN2O/c1-2-18-12-15(9-10-21-18)19(23)22-11-3-4-16(13-22)14-5-7-17(20)8-6-14/h5-10,12,16H,2-4,11,13H2,1H3
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347539
PNG
(4-{[3-(4-Chloro-2-fluorophenyl)piperidin-1-yl]carb...)
Show SMILES CN(C)c1cc(ccn1)C(=O)N1CCCC(C1)c1ccc(Cl)cc1F
Show InChI InChI=1S/C19H21ClFN3O/c1-23(2)18-10-13(7-8-22-18)19(25)24-9-3-4-14(12-24)16-6-5-15(20)11-17(16)21/h5-8,10-11,14H,3-4,9,12H2,1-2H3
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347615
PNG
(4-({3-[4-Chloro-2-(trifluoromethyl)phenyl]piperidi...)
Show SMILES Cn1cc(C(=O)N2CCCC(C2)c2ccc(Cl)cc2C(F)(F)F)c(N)n1
Show InChI InChI=1S/C17H18ClF3N4O/c1-24-9-13(15(22)23-24)16(26)25-6-2-3-10(8-25)12-5-4-11(18)7-14(12)17(19,20)21/h4-5,7,9-10H,2-3,6,8H2,1H3,(H2,22,23)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347605
PNG
(3-(4-Chlorophenyl)-1-[(1-ethyl-1H-pyrazol-4-yl)car...)
Show SMILES CCn1cc(cn1)C(=O)N1CCCC(C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C17H20ClN3O/c1-2-21-12-15(10-19-21)17(22)20-9-3-4-14(11-20)13-5-7-16(18)8-6-13/h5-8,10,12,14H,2-4,9,11H2,1H3
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347580
PNG
(4-({3-[2-(Difluoromethoxy)phenyl]piperidin-1-yl}ca...)
Show SMILES CN(C)c1cc(ccn1)C(=O)N1CCCC(C1)c1ccccc1OC(F)F
Show InChI InChI=1S/C20H23F2N3O2/c1-24(2)18-12-14(9-10-23-18)19(26)25-11-5-6-15(13-25)16-7-3-4-8-17(16)27-20(21)22/h3-4,7-10,12,15,20H,5-6,11,13H2,1-2H3
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347592
PNG
(3-(Azetidin-1-yl)-5-({3-[4-chloro-2-(trifluorometh...)
Show SMILES FC(F)(F)c1cc(Cl)ccc1C1CCCN(C1)C(=O)c1cnnc(c1)N1CCC1
Show InChI InChI=1S/C20H20ClF3N4O/c21-15-4-5-16(17(10-15)20(22,23)24)13-3-1-6-28(12-13)19(29)14-9-18(26-25-11-14)27-7-2-8-27/h4-5,9-11,13H,1-3,6-8,12H2
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n/an/a 730n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347583
PNG
(5-{[3-(4-Chlorophenyl)piperidin-1-yl]carbonyl}-N,N...)
Show SMILES CN(C)c1cc(cnn1)C(=O)N1CCCC(C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C18H21ClN4O/c1-22(2)17-10-15(11-20-21-17)18(24)23-9-3-4-14(12-23)13-5-7-16(19)8-6-13/h5-8,10-11,14H,3-4,9,12H2,1-2H3
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n/an/a 810n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347572
PNG
(2-Ethyl-4-({3-[2-(trifluoromethyl)phenyl]piperidin...)
Show SMILES CCc1cc(ccn1)C(=O)N1CCCC(C1)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C20H21F3N2O/c1-2-16-12-14(9-10-24-16)19(26)25-11-5-6-15(13-25)17-7-3-4-8-18(17)20(21,22)23/h3-4,7-10,12,15H,2,5-6,11,13H2,1H3
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n/an/a 820n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347544
PNG
(4-{[3-(4-Chlorophenyl)piperidin-1-yl]carbonyl}-2-(...)
Show SMILES CC(C)c1cc(ccn1)C(=O)N1CCCC(C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H23ClN2O/c1-14(2)19-12-16(9-10-22-19)20(24)23-11-3-4-17(13-23)15-5-7-18(21)8-6-15/h5-10,12,14,17H,3-4,11,13H2,1-2H3
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n/an/a 830n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347531
PNG
(4-{[(3S)-3-(4-Chlorophenyl)piperidin-1-yl]carbonyl...)
Show SMILES CN(C)c1cc(ccn1)C(=O)N1CCC[C@H](C1)c1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C19H22ClN3O/c1-22(2)18-12-15(9-10-21-18)19(24)23-11-3-4-16(13-23)14-5-7-17(20)8-6-14/h5-10,12,16H,3-4,11,13H2,1-2H3/t16-/m1/s1
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n/an/a 840n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347628
PNG
(5-{[3-(4-Chlorophenyl)azepan-1-yl]carbonyl}-N-meth...)
Show SMILES CNc1cc(cnn1)C(=O)N1CCCCC(C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C18H21ClN4O/c1-20-17-10-15(11-21-22-17)18(24)23-9-3-2-4-14(12-23)13-5-7-16(19)8-6-13/h5-8,10-11,14H,2-4,9,12H2,1H3,(H,20,22)
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n/an/a 930n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347537
PNG
(2-(Azetidin-1-yl)-4-{[3-(2-methylphenyl)piperidin-...)
Show SMILES Cc1ccccc1C1CCCN(C1)C(=O)c1ccnc(c1)N1CCC1
Show InChI InChI=1S/C21H25N3O/c1-16-6-2-3-8-19(16)18-7-4-11-24(15-18)21(25)17-9-10-22-20(14-17)23-12-5-13-23/h2-3,6,8-10,14,18H,4-5,7,11-13,15H2,1H3
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n/an/a 960n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347606
PNG
(3-(4-Chlorophenyl)-1-{[1-(propan-2-yl)-1H-pyrazol-...)
Show SMILES CC(C)n1cc(cn1)C(=O)N1CCCC(C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C18H22ClN3O/c1-13(2)22-12-16(10-20-22)18(23)21-9-3-4-15(11-21)14-5-7-17(19)8-6-14/h5-8,10,12-13,15H,3-4,9,11H2,1-2H3
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n/an/a 960n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347624
PNG
(4-{[3-(4-Methoxyphenyl)azepan-1-yl]carbonyl}-N,N-d...)
Show SMILES COc1ccc(cc1)C1CCCCN(C1)C(=O)c1ccnc(c1)N(C)C
Show InChI InChI=1S/C21H27N3O2/c1-23(2)20-14-17(11-12-22-20)21(25)24-13-5-4-6-18(15-24)16-7-9-19(26-3)10-8-16/h7-12,14,18H,4-6,13,15H2,1-3H3
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n/an/a 960n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347525
PNG
(3-Chloro-5-{[3-(2-methoxyphenyl)piperidin-1-yl]car...)
Show SMILES CN(C)c1cc(ccn1)C(=O)N1CCCC(C1)c1ccc(C)cc1
Show InChI InChI=1S/C20H25N3O/c1-15-6-8-16(9-7-15)18-5-4-12-23(14-18)20(24)17-10-11-21-19(13-17)22(2)3/h6-11,13,18H,4-5,12,14H2,1-3H3
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n/an/a 990n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347616
PNG
(1-[(1,3-Dimethyl-1H-pyrazol-4-yl)carbonyl]-3-(4-me...)
Show SMILES COc1ccc(C2CCCN(C2)C(=O)c2cn(C)nc2C)c(C)c1
Show InChI InChI=1S/C19H25N3O2/c1-13-10-16(24-4)7-8-17(13)15-6-5-9-22(11-15)19(23)18-12-21(3)20-14(18)2/h7-8,10,12,15H,5-6,9,11H2,1-4H3
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n/an/a 1.03E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347536
PNG
(2-(Azetidin-1-yl)-4-{[3-(4-chlorophenyl)piperidin-...)
Show SMILES Clc1ccc(cc1)C1CCCN(C1)C(=O)c1ccnc(c1)N1CCC1
Show InChI InChI=1S/C20H22ClN3O/c21-18-6-4-15(5-7-18)17-3-1-10-24(14-17)20(25)16-8-9-22-19(13-16)23-11-2-12-23/h4-9,13,17H,1-3,10-12,14H2
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n/an/a 1.04E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347600
PNG
(5-{[3-(4-Chloro-2-methylphenyl)piperidin-1-yl]carb...)
Show SMILES Cc1cc(cnn1)C(=O)N1CCCC(C1)c1ccc(Cl)cc1C
Show InChI InChI=1S/C18H20ClN3O/c1-12-8-16(19)5-6-17(12)14-4-3-7-22(11-14)18(23)15-9-13(2)21-20-10-15/h5-6,8-10,14H,3-4,7,11H2,1-2H3
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n/an/a 1.14E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347529
PNG
(N,N-Dimethyl-4-[(3-phenylpiperidin-1-yl)carbonyl]p...)
Show SMILES CN(C)c1cc(ccn1)C(=O)N1CCCC(C1)c1ccccc1
Show InChI InChI=1S/C19H23N3O/c1-21(2)18-13-16(10-11-20-18)19(23)22-12-6-9-17(14-22)15-7-4-3-5-8-15/h3-5,7-8,10-11,13,17H,6,9,12,14H2,1-2H3
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n/an/a 1.14E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347524
PNG
(3-Chloro-4-{[3-(4-chloro-2-methylphenyl)piperidin-...)
Show SMILES Cc1cc(ccn1)C(=O)N1CCCC(C1)c1ccc(Cl)cc1C(F)(F)F
Show InChI InChI=1S/C19H18ClF3N2O/c1-12-9-13(6-7-24-12)18(26)25-8-2-3-14(11-25)16-5-4-15(20)10-17(16)19(21,22)23/h4-7,9-10,14H,2-3,8,11H2,1H3
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n/an/a 1.17E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347587
PNG
(5-{[(3S)-3-(4-Chloro-2-methylphenyl)piperidin-1-yl...)
Show SMILES CNc1cc(cnn1)C(=O)N1CCC[C@H](C1)c1ccc(Cl)cc1C
Show InChI InChI=1S/C18H21ClN4O/c1-12-8-15(19)5-6-16(12)13-4-3-7-23(11-13)18(24)14-9-17(20-2)22-21-10-14/h5-6,8-10,13H,3-4,7,11H2,1-2H3,(H,20,22)/t13-/m1/s1
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n/an/a 1.18E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347535
PNG
(2-(Azetidin-1-yl)-4-{[3-(4-methylphenyl)piperidin-...)
Show SMILES Cc1ccc(cc1)C1CCCN(C1)C(=O)c1ccnc(c1)N1CCC1
Show InChI InChI=1S/C21H25N3O/c1-16-5-7-17(8-6-16)19-4-2-11-24(15-19)21(25)18-9-10-22-20(14-18)23-12-3-13-23/h5-10,14,19H,2-4,11-13,15H2,1H3
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n/an/a 1.20E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347534
PNG
(2-Ethyl-4-{[3-(4-methylphenyl)piperidin-1-yl]carbo...)
Show SMILES CCc1cc(ccn1)C(=O)N1CCCC(C1)c1ccc(C)cc1
Show InChI InChI=1S/C20H24N2O/c1-3-19-13-17(10-11-21-19)20(23)22-12-4-5-18(14-22)16-8-6-15(2)7-9-16/h6-11,13,18H,3-5,12,14H2,1-2H3
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n/an/a 1.21E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347533
PNG
(4-{[3-(4-Fluorophenyl)piperidin-1-yl]carbonyl}-N,N...)
Show SMILES CN(C)c1cc(ccn1)C(=O)N1CCCC(C1)c1ccc(F)cc1
Show InChI InChI=1S/C19H22FN3O/c1-22(2)18-12-15(9-10-21-18)19(24)23-11-3-4-16(13-23)14-5-7-17(20)8-6-14/h5-10,12,16H,3-4,11,13H2,1-2H3
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n/an/a 1.22E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347621
PNG
(4-{[5-(2,4-Dichlorophenyl)-1,2,3,4-tetrahydropyrid...)
Show SMILES CN(C)c1cc(ccn1)C(=O)N1CCCC(=C1)c1ccc(Cl)cc1Cl |c:16|
Show InChI InChI=1S/C19H19Cl2N3O/c1-23(2)18-10-13(7-8-22-18)19(25)24-9-3-4-14(12-24)16-6-5-15(20)11-17(16)21/h5-8,10-12H,3-4,9H2,1-2H3
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n/an/a 1.23E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347601
PNG
(5-{[3-(2-Methoxyphenyl)piperidin-1-yl]carbonyl}-N-...)
Show SMILES CNc1cc(cnn1)C(=O)N1CCCC(C1)c1ccccc1OC
Show InChI InChI=1S/C18H22N4O2/c1-19-17-10-14(11-20-21-17)18(23)22-9-5-6-13(12-22)15-7-3-4-8-16(15)24-2/h3-4,7-8,10-11,13H,5-6,9,12H2,1-2H3,(H,19,21)
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n/an/a 1.26E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347627
PNG
(5-{[3-(4-Methoxyphenyl)azepan-1-yl]carbonyl}-N-met...)
Show SMILES CNc1cc(cnn1)C(=O)N1CCCCC(C1)c1ccc(OC)cc1
Show InChI InChI=1S/C19H24N4O2/c1-20-18-11-16(12-21-22-18)19(24)23-10-4-3-5-15(13-23)14-6-8-17(25-2)9-7-14/h6-9,11-12,15H,3-5,10,13H2,1-2H3,(H,20,22)
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n/an/a 1.27E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347604
PNG
(3-(4-Chlorophenyl)-1-[(1-methyl-1H-pyrazol-4-yl)ca...)
Show SMILES Cn1cc(cn1)C(=O)N1CCCC(C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C16H18ClN3O/c1-19-10-14(9-18-19)16(21)20-8-2-3-13(11-20)12-4-6-15(17)7-5-12/h4-7,9-10,13H,2-3,8,11H2,1H3
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n/an/a 1.28E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347542
PNG
(4-{[3-(4-Chlorophenyl)piperidin-1-yl]carbonyl}-2,6...)
Show SMILES Cc1cc(cc(C)n1)C(=O)N1CCCC(C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H21ClN2O/c1-13-10-17(11-14(2)21-13)19(23)22-9-3-4-16(12-22)15-5-7-18(20)8-6-15/h5-8,10-11,16H,3-4,9,12H2,1-2H3
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n/an/a 1.33E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347631
PNG
(3-(4-Chloro-2-methylphenyl)-1-{[2-(dimethylamino)p...)
Show SMILES CN(C)c1cc(ccn1)C(=O)N1CCCC(O)(C1)c1ccc(Cl)cc1C
Show InChI InChI=1S/C20H24ClN3O2/c1-14-11-16(21)5-6-17(14)20(26)8-4-10-24(13-20)19(25)15-7-9-22-18(12-15)23(2)3/h5-7,9,11-12,26H,4,8,10,13H2,1-3H3
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n/an/a 1.36E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347523
PNG
(4-({3-[4-Chloro-2-(trifluoromethyl)phenyl]piperidi...)
Show SMILES COc1cc(ccn1)C(=O)N1CCCC(C1)c1ccc(Cl)cc1C(F)(F)F
Show InChI InChI=1S/C19H18ClF3N2O2/c1-27-17-9-12(6-7-24-17)18(26)25-8-2-3-13(11-25)15-5-4-14(20)10-16(15)19(21,22)23/h4-7,9-10,13H,2-3,8,11H2,1H3
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n/an/a 1.37E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347629
PNG
(5-{[3-(4-Methoxyphenyl)azepan-1-yl]carbonyl}-N,N-d...)
Show SMILES COc1ccc(cc1)C1CCCCN(C1)C(=O)c1cnnc(c1)N(C)C
Show InChI InChI=1S/C20H26N4O2/c1-23(2)19-12-17(13-21-22-19)20(25)24-11-5-4-6-16(14-24)15-7-9-18(26-3)10-8-15/h7-10,12-13,16H,4-6,11,14H2,1-3H3
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n/an/a 1.43E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347630
PNG
(5-{[3-(4-Chlorophenyl)azepan-1-yl]carbonyl}-N,N-di...)
Show SMILES CN(C)c1cc(cnn1)C(=O)N1CCCCC(C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H23ClN4O/c1-23(2)18-11-16(12-21-22-18)19(25)24-10-4-3-5-15(13-24)14-6-8-17(20)9-7-14/h6-9,11-12,15H,3-5,10,13H2,1-2H3
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n/an/a 1.44E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347617
PNG
(4-{[3-(4-Methoxy-2-methylphenyl)piperidin-1-yl]car...)
Show SMILES COc1ccc(C2CCCN(C2)C(=O)c2cn(C)nc2N)c(C)c1
Show InChI InChI=1S/C18H24N4O2/c1-12-9-14(24-3)6-7-15(12)13-5-4-8-22(10-13)18(23)16-11-21(2)20-17(16)19/h6-7,9,11,13H,4-5,8,10H2,1-3H3,(H2,19,20)
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n/an/a 1.54E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347582
PNG
(4-{[3-(4-Chloro-2,6-dimethylphenyl)piperidin-1-yl]...)
Show SMILES CN(C)c1cc(ccn1)C(=O)N1CCCC(C1)c1c(C)cc(Cl)cc1C
Show InChI InChI=1S/C21H26ClN3O/c1-14-10-18(22)11-15(2)20(14)17-6-5-9-25(13-17)21(26)16-7-8-23-19(12-16)24(3)4/h7-8,10-12,17H,5-6,9,13H2,1-4H3
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n/an/a 1.54E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347573
PNG
(2-Ethyl-4-{[3-(2-methoxyphenyl)piperidin-1-yl]carb...)
Show SMILES CCc1cc(ccn1)C(=O)N1CCCC(C1)c1ccccc1OC
Show InChI InChI=1S/C20H24N2O2/c1-3-17-13-15(10-11-21-17)20(23)22-12-6-7-16(14-22)18-8-4-5-9-19(18)24-2/h4-5,8-11,13,16H,3,6-7,12,14H2,1-2H3
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n/an/a 1.60E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347574
PNG
(N,N-Dimethyl-4-({3-[2-(trifluoromethoxy)phenyl]pip...)
Show SMILES CN(C)c1cc(ccn1)C(=O)N1CCCC(C1)c1ccccc1OC(F)(F)F
Show InChI InChI=1S/C20H22F3N3O2/c1-25(2)18-12-14(9-10-24-18)19(27)26-11-5-6-15(13-26)16-7-3-4-8-17(16)28-20(21,22)23/h3-4,7-10,12,15H,5-6,11,13H2,1-2H3
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n/an/a 1.60E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347517
PNG
(4-{[3-(4-Chlorophenyl)piperidin-1-yl]carbonyl}-2-c...)
Show SMILES Clc1ccc(cc1)C1CCCN(C1)C(=O)c1ccnc(c1)C1CC1
Show InChI InChI=1S/C20H21ClN2O/c21-18-7-5-14(6-8-18)17-2-1-11-23(13-17)20(24)16-9-10-22-19(12-16)15-3-4-15/h5-10,12,15,17H,1-4,11,13H2
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n/an/a 1.74E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347603
PNG
(3-(4-Chlorophenyl)-1-[(1,3-dimethyl-1H-pyrazol-4-y...)
Show SMILES Cc1nn(C)cc1C(=O)N1CCCC(C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C17H20ClN3O/c1-12-16(11-20(2)19-12)17(22)21-9-3-4-14(10-21)13-5-7-15(18)8-6-13/h5-8,11,14H,3-4,9-10H2,1-2H3
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n/an/a 1.82E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347515
PNG
(4-{[3-(2-Fluorophenyl)piperidin-1-yl]carbonyl}-N,N...)
Show SMILES CN(C)c1cc(ccn1)C(=O)N1CCCC(C1)c1ccccc1F
Show InChI InChI=1S/C19H22FN3O/c1-22(2)18-12-14(9-10-21-18)19(24)23-11-5-6-15(13-23)16-7-3-4-8-17(16)20/h3-4,7-10,12,15H,5-6,11,13H2,1-2H3
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n/an/a 1.82E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347527
PNG
(N,N-Dimethyl-4-{[3-(3-methylphenyl)piperidin-1-yl]...)
Show SMILES CN(C)c1cc(ccn1)C(=O)N1CCCC(C1)c1cccc(C)c1
Show InChI InChI=1S/C20H25N3O/c1-15-6-4-7-16(12-15)18-8-5-11-23(14-18)20(24)17-9-10-21-19(13-17)22(2)3/h4,6-7,9-10,12-13,18H,5,8,11,14H2,1-3H3
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n/an/a 1.92E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347581
PNG
(2-(1-{[2-(Dimethylamino)pyridin-4-yl]carbonyl}pipe...)
Show SMILES CN(C)c1cc(ccn1)C(=O)N1CCCC(C1)c1ccccc1C#N
Show InChI InChI=1S/C20H22N4O/c1-23(2)19-12-15(9-10-22-19)20(25)24-11-5-7-17(14-24)18-8-4-3-6-16(18)13-21/h3-4,6,8-10,12,17H,5,7,11,14H2,1-2H3
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n/an/a 2.26E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347611
PNG
(3-[4-Chloro-2-(trifluoromethyl)phenyl]-1-[(1H-pyra...)
Show SMILES FC(F)(F)c1cc(Cl)ccc1C1CCCN(C1)C(=O)c1cn[nH]c1
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n/an/a 2.44E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347526
PNG
(2-Methyl-4-{[3-(4-methylphenyl)piperidin-1-yl]carb...)
Show SMILES Cc1ccc(cc1)C1CCCN(C1)C(=O)c1ccnc(C)c1
Show InChI InChI=1S/C19H22N2O/c1-14-5-7-16(8-6-14)18-4-3-11-21(13-18)19(22)17-9-10-20-15(2)12-17/h5-10,12,18H,3-4,11,13H2,1-2H3
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n/an/a 2.80E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347567
PNG
(N-Methyl-4-({3-[4-(trifluoromethyl)phenyl]piperidi...)
Show SMILES CNc1cc(ccn1)C(=O)N1CCCC(C1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C19H20F3N3O/c1-23-17-11-14(8-9-24-17)18(26)25-10-2-3-15(12-25)13-4-6-16(7-5-13)19(20,21)22/h4-9,11,15H,2-3,10,12H2,1H3,(H,23,24)
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n/an/a 2.92E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347622
PNG
(N,N-Dimethyl-4-[(3-phenylazepan-1-yl)carbonyl]pyri...)
Show SMILES CN(C)c1cc(ccn1)C(=O)N1CCCCC(C1)c1ccccc1
Show InChI InChI=1S/C20H25N3O/c1-22(2)19-14-17(11-12-21-19)20(24)23-13-7-6-10-18(15-23)16-8-4-3-5-9-16/h3-5,8-9,11-12,14,18H,6-7,10,13,15H2,1-2H3
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n/an/a 2.97E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347593
PNG
(5-({3-[2-Methoxy-4-(trifluoromethyl)phenyl]piperid...)
Show SMILES CNc1cc(cnn1)C(=O)N1CCCC(C1)c1ccc(cc1OC)C(F)(F)F
Show InChI InChI=1S/C19H21F3N4O2/c1-23-17-8-13(10-24-25-17)18(27)26-7-3-4-12(11-26)15-6-5-14(19(20,21)22)9-16(15)28-2/h5-6,8-10,12H,3-4,7,11H2,1-2H3,(H,23,25)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347623
PNG
(4-{[3-(4-Chlorophenyl)azepan-1-yl]carbonyl}-N,N-di...)
Show SMILES CN(C)c1cc(ccn1)C(=O)N1CCCCC(C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H24ClN3O/c1-23(2)19-13-16(10-11-22-19)20(25)24-12-4-3-5-17(14-24)15-6-8-18(21)9-7-15/h6-11,13,17H,3-5,12,14H2,1-2H3
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n/an/a 3.23E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347522
PNG
(3-Chloro-5-({3-[4-methoxy-2-(trifluoromethyl)pheny...)
Show SMILES CC(C)Nc1cc(ccn1)C(=O)N1CCCC(C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H24ClN3O/c1-14(2)23-19-12-16(9-10-22-19)20(25)24-11-3-4-17(13-24)15-5-7-18(21)8-6-15/h5-10,12,14,17H,3-4,11,13H2,1-2H3,(H,22,23)
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n/an/a 3.27E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347543
PNG
(2-Chloro-4-{[3-(4-chlorophenyl)piperidin-1-yl]carb...)
Show SMILES Clc1ccc(cc1)C1CCCN(C1)C(=O)c1ccnc(Cl)c1
Show InChI InChI=1S/C17H16Cl2N2O/c18-15-5-3-12(4-6-15)14-2-1-9-21(11-14)17(22)13-7-8-20-16(19)10-13/h3-8,10,14H,1-2,9,11H2
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n/an/a 3.29E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347632
PNG
(1-{[2-(Dimethylamino)pyridin-4-yl]carbonyl}-3-(4-f...)
Show SMILES CN(C)c1cc(ccn1)C(=O)N1CCCC(O)(C1)c1ccc(F)cc1
Show InChI InChI=1S/C19H22FN3O2/c1-22(2)17-12-14(8-10-21-17)18(24)23-11-3-9-19(25,13-23)15-4-6-16(20)7-5-15/h4-8,10,12,25H,3,9,11,13H2,1-2H3
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n/an/a 3.94E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347558
PNG
(N,N-Dimethyl-4-({3-[4-(trifluoromethyl)phenyl]pipe...)
Show SMILES CN(C)c1cc(ccn1)C(=O)N1CCCC(C1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C20H22F3N3O/c1-25(2)18-12-15(9-10-24-18)19(27)26-11-3-4-16(13-26)14-5-7-17(8-6-14)20(21,22)23/h5-10,12,16H,3-4,11,13H2,1-2H3
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n/an/a 4.40E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347548
PNG
(2-Methoxy-4-{[3-(4-methylphenyl)piperidin-1-yl]car...)
Show SMILES COc1cc(ccn1)C(=O)N1CCCC(C1)c1ccc(C)cc1
Show InChI InChI=1S/C19H22N2O2/c1-14-5-7-15(8-6-14)17-4-3-11-21(13-17)19(22)16-9-10-20-18(12-16)23-2/h5-10,12,17H,3-4,11,13H2,1-2H3
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n/an/a 5.27E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347550
PNG
(4-{[(3S)-3-(3-Methoxyphenyl)piperidin-1-yl]carbony...)
Show SMILES COc1cccc(c1)[C@@H]1CCCN(C1)C(=O)c1ccnc(c1)N(C)C |r|
Show InChI InChI=1S/C20H25N3O2/c1-22(2)19-13-16(9-10-21-19)20(24)23-11-5-7-17(14-23)15-6-4-8-18(12-15)25-3/h4,6,8-10,12-13,17H,5,7,11,14H2,1-3H3/t17-/m1/s1
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n/an/a 5.51E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347551
PNG
(N-Ethyl-N-methyl-4-{[3-(4-methylphenyl)piperidin-1...)
Show SMILES CCN(C)c1cc(ccn1)C(=O)N1CCCC(C1)c1ccc(C)cc1
Show InChI InChI=1S/C21H27N3O/c1-4-23(3)20-14-18(11-12-22-20)21(25)24-13-5-6-19(15-24)17-9-7-16(2)8-10-17/h7-12,14,19H,4-6,13,15H2,1-3H3
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n/an/a 5.53E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347552
PNG
(2-(3,3-Difluoroazetidin-1-yl)-4-{[3-(4-methylpheny...)
Show SMILES Cc1ccc(cc1)C1CCCN(C1)C(=O)c1ccnc(c1)N1CC(F)(F)C1
Show InChI InChI=1S/C21H23F2N3O/c1-15-4-6-16(7-5-15)18-3-2-10-25(12-18)20(27)17-8-9-24-19(11-17)26-13-21(22,23)14-26/h4-9,11,18H,2-3,10,12-14H2,1H3
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n/an/a 6.50E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347554
PNG
(N-Methyl-4-{[3-(4-methylphenyl)piperidin-1-yl]carb...)
Show SMILES CC(C)N(C)c1cc(ccn1)C(=O)N1CCCC(C1)c1ccc(C)cc1
Show InChI InChI=1S/C22H29N3O/c1-16(2)24(4)21-14-19(11-12-23-21)22(26)25-13-5-6-20(15-25)18-9-7-17(3)8-10-18/h7-12,14,16,20H,5-6,13,15H2,1-4H3
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n/an/a 7.03E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347557
PNG
(N-Cyclopropyl-N-methyl-4-{[3-(4-methylphenyl)piper...)
Show SMILES CN(C1CC1)c1cc(ccn1)C(=O)N1CCCC(C1)c1ccc(C)cc1
Show InChI InChI=1S/C22H27N3O/c1-16-5-7-17(8-6-16)19-4-3-13-25(15-19)22(26)18-11-12-23-21(14-18)24(2)20-9-10-20/h5-8,11-12,14,19-20H,3-4,9-10,13,15H2,1-2H3
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n/an/a 7.05E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347560
PNG
(4-{[3-(2-Chlorophenyl)piperidin-1-yl]carbonyl}-N,N...)
Show SMILES CN(C)c1cc(ccn1)C(=O)N1CCCC(C1)c1ccccc1Cl
Show InChI InChI=1S/C19H22ClN3O/c1-22(2)18-12-14(9-10-21-18)19(24)23-11-5-6-15(13-23)16-7-3-4-8-17(16)20/h3-4,7-10,12,15H,5-6,11,13H2,1-2H3
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n/an/a 7.79E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347553
PNG
(N-Methyl-4-{[3-(4-methylphenyl)piperidin-1-yl]carb...)
Show SMILES CCCN(C)c1cc(ccn1)C(=O)N1CCCC(C1)c1ccc(C)cc1
Show InChI InChI=1S/C22H29N3O/c1-4-13-24(3)21-15-19(11-12-23-21)22(26)25-14-5-6-20(16-25)18-9-7-17(2)8-10-18/h7-12,15,20H,4-6,13-14,16H2,1-3H3
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n/an/a 8.22E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347556
PNG
(4-{[3-(4-Chlorophenyl)piperidin-1-yl]carbonyl}-2-e...)
Show SMILES CCOc1cc(ccn1)C(=O)N1CCCC(C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H21ClN2O2/c1-2-24-18-12-15(9-10-21-18)19(23)22-11-3-4-16(13-22)14-5-7-17(20)8-6-14/h5-10,12,16H,2-4,11,13H2,1H3
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n/an/a 8.35E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347555
PNG
(1-(4-{[3-(4-Methylphenyl)piperidin-1-yl]carbonyl}p...)
Show SMILES Cc1ccc(cc1)C1CCCN(C1)C(=O)c1ccnc(c1)N1CC(O)C1
Show InChI InChI=1S/C21H25N3O2/c1-15-4-6-16(7-5-15)18-3-2-10-23(12-18)21(26)17-8-9-22-20(11-17)24-13-19(25)14-24/h4-9,11,18-19,25H,2-3,10,12-14H2,1H3
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n/an/a 8.46E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347549
PNG
(4-{[3-(4-Methylphenyl)piperidin-1-yl]carbonyl}-2-(...)
Show SMILES Cc1ccc(cc1)C1CCCN(C1)C(=O)c1ccnc(c1)N1CCCC1
Show InChI InChI=1S/C22H27N3O/c1-17-6-8-18(9-7-17)20-5-4-14-25(16-20)22(26)19-10-11-23-21(15-19)24-12-2-3-13-24/h6-11,15,20H,2-5,12-14,16H2,1H3
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n/an/a 8.82E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM347615
PNG
(4-({3-[4-Chloro-2-(trifluoromethyl)phenyl]piperidi...)
Show SMILES Cn1cc(C(=O)N2CCCC(C2)c2ccc(Cl)cc2C(F)(F)F)c(N)n1
Show InChI InChI=1S/C17H18ClF3N4O/c1-24-9-13(15(22)23-24)16(26)25-6-2-3-10(8-25)12-5-4-11(18)7-14(12)17(19,20)21/h4-5,7,9-10H,2-3,6,8H2,1H3,(H2,22,23)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9790201 (2017)


BindingDB Entry DOI: 10.7270/Q2377BVZ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%