280 articles for thisTarget

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PMID	Data	Article Title	Organization
28277660	30	Discovery of Potent and Orally Bioavailable GPR40 Full Agonists Bearing Thiophen-2-ylpropanoic Acid Scaffold.	Shanghai Institute Of Materia Medica
28076827	27	New diphenylmethane derivatives as peroxisome proliferator-activated receptor alpha/gamma dual agonists endowed with anti-proliferative effects and mitochondrial activity.	Universit£
27918994	18	Importance of 5/6-aryl substitution on the pharmacological profile of 4'-((2-propyl-1H-benzo[d]imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid derived PPAR¿ agonists.	University Of Innsbruck
28117121	9	Design, synthesis, molecular modeling and anti-hyperglycemic evaluation of novel quinoxaline derivatives as potential PPAR¿ and SUR agonists.	Al-Azhar University
27876250	60	Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH	Jagiellonian University Medical College
27560282	11	Evaluation of selected 3D virtual screening tools for the prospective identification of peroxisome proliferator-activated receptor (PPAR)¿ partial agonists.	University Of Innsbruck
27569195	16	New telmisartan-derived PPAR¿ agonists: Impact of the 3D-binding mode on the pharmacological profile.	Universit£T Innsbruck
27815118	112	Discovery of phenoxyindazoles and phenylthioindazoles as ROR¿ inverse agonists.	Galderma R & D
27591006	24	Discovery of N-(1-(3-(4-phenoxyphenyl)-1,2,4-oxadiazol-5-yl)ethyl)acetamides as novel acetyl-CoA carboxylase 2 (ACC2) inhibitors with peroxisome proliferator-activated receptora/d (PPARa/d) dual agonistic activity.	The University Of Tokyo
27326332	66	Discovery and Preclinical Evaluation of BMS-711939, an Oxybenzylglycine Based PPARa Selective Agonist.	Bristol-Myers Squibb
26988801	55	Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.	Jagiellonian University Medical College
26819660	82	SAR Exploration Guided by LE and Fsp(3): Discovery of a Selective and Orally Efficacious ROR¿ Inhibitor.	Central Pharmaceutical Research Institute
27020685	4	Synthetic approaches to the 2014 new drugs.	Pfizer
26731300	3	Amorfrutin C Induces Apoptosis and Inhibits Proliferation in Colon Cancer Cells through Targeting Mitochondria.	Max Planck Institute For Molecular Genetics
26595749	77	N-Benzylbenzamides: A Novel Merged Scaffold for Orally Available Dual Soluble Epoxide Hydrolase/Peroxisome Proliferator-Activated Receptor¿ Modulators.	Goethe-University Frankfurt
26708109	10	Design and synthesis of novel Y-shaped barbituric acid derivatives as PPAR¿ activators.	National Institute Of Pharmaceutical Education And Research (Niper)
26707398	2	Characterization of isobutylhydroxyamides with NGF-potentiating activity from Zanthoxylum bungeanum.	Northwest A & F University
26258602	39	Discovery of Selective Small Molecule Inhibitors of Monoacylglycerol Acyltransferase 3.	Pfizer
26226490	23	Novel Oxazolidinone-Based Peroxisome Proliferator Activated Receptor Agonists: Molecular Modeling, Synthesis, and Biological Evaluation.	Iqm-Csic
26048793	91	Discovery of imidazo[1,5-a]pyridines and -pyrimidines as potent and selective RORc inverse agonists.	Genentech
25982078	13	Design, synthesis, and biological evaluation of a series of alkoxy-3-indolylacetic acids as peroxisome proliferator-activated receptor¿/d agonists.	Sookmyung Women'S University
25583100	107	Anthranilic acid derivatives as nuclear receptor modulators--development of novel PPAR selective and dual PPAR/FXR ligands.	Goethe-University Frankfurt
25262940	3	2-(2-Bromophenyl)-formononetin and 2-heptyl-formononetin are PPAR¿ partial agonists and reduce lipid accumulation in 3T3-L1 adipocytes.	University Of Copenhagen
25938459	1	Amorfrutins Are Natural PPAR¿ Agonists with Potent Anti-inflammatory Properties.	Max Planck Institute For Molecular Genetics
25890697	6	Thiazolidine-2,4-dione derivatives: programmed chemical weapons for key protein targets of various pathological conditions.	Punjabi University
25734377	11	Peroxisome Proliferator-Activated Receptor¿ (PPAR¿) and Ligand Choreography: Newcomers Take the Stage.	Universitat Rovira I Virgili (Urv)
25815144	17	Discovery of DS-1558: A Potent and Orally Bioavailable GPR40 Agonist.	Daiichi Sankyo
25978962	8	Separation and peroxisome proliferator-activated receptor-¿ agonist activity evaluation of synthetic racemic bavachinin enantiomers.	Shanghai University Of Traditional Chinese Medicine
25686852	191	Synthesis and biological evaluation of novel pyrrolidine acid analogs as potent dual PPARa/¿ agonists.	Bristol-Myers Squibb Research And Development (R & D)
25575659	124	SAR-studies of¿-secretase modulators with PPAR¿-agonistic and 5-lipoxygenase-inhibitory activity for Alzheimer's disease.	Goethe-University Frankfurt
25497132	34	Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptora/¿ ligand LT175.	Universit£
25037914	76	Identification of pirinixic acid derivatives bearing a 2-aminothiazole moiety combines dual PPARa/¿ activation and dual 5-LO/mPGES-1 inhibition.	Goethe-University Frankfurt
25022880	24	Molecular determinants for improved activity at PPARa: structure-activity relationship of pirinixic acid derivatives, docking study and site-directed mutagenesis of PPARa.	Goethe-University Frankfurt
25017035	20	Molecular dynamics study-guided identification of cyclic amine structures as novel hydrophobic tail components of hPPAR¿ agonists.	Okayama University
24881566	140	Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120).	Glaxosmithkline
25491112	19	Biological evaluation and structural insights for design of subtype-selective peroxisome proliferator activated receptor-a (PPAR-a) agonists.	National Institute Of Pharmaceutical Education And Research (Niper)
25462281	17	Structural development studies of PPARs ligands based on tyrosine scaffold.	Universit£&Quot;G. D'Annunzio&Quot
25333853	6	Polyyne hybrid compounds from Notopterygium incisum with peroxisome proliferator-activated receptor gamma agonistic effects.	Karl-Franzens-University Graz
25305688	41	Identification of the first inverse agonist of retinoid-related orphan receptor (ROR) with dual selectivity for RORß and ROR¿t.	Phenex Pharmaceuticals
25255039	45	Extending the structure-activity relationship of anthranilic acid derivatives as farnesoid X receptor modulators: development of a highly potent partial farnesoid X receptor agonist.	Goethe-University Frankfurt
24821375	5	The dipeptide H-Trp-Glu-OH (WE) shows agonistic activity to peroxisome proliferator-activated protein-a and reduces hepatic lipid accumulation in lipid-loaded H4IIE cells.	Korea University
24745969	36	Identification of the first potent, selective and bioavailable PPARa antagonist.	Inception Sciences
9836620	94	N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents.	Glaxo Wellcome Research And Development
23294830	88	Discovery of INT131: a selective PPAR¿ modulator that enhances insulin sensitivity.	Amgen
23286787	18	Structural characterization of amorfrutins bound to the peroxisome proliferator-activated receptor¿.	Helmholtz Centre For Infection Research
23265844	18	The discovery of novel isoflavone pan peroxisome proliferator-activated receptor agonists.	The University Of Sydney
23265881	49	Design, synthesis, and evaluation of imidazo[4,5-c]pyridin-4-one derivatives with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-¿.	Pfizer
24900572	54	Discovery of HSD-621 as a Potential Agent for the Treatment of Type 2 Diabetes.	Pfizer
23171045	38	New 2-(aryloxy)-3-phenylpropanoic acids as peroxisome proliferator-activated receptora/¿ dual agonists able to upregulate mitochondrial carnitine shuttle system gene expression.	Universit�
17533125	36	Co-crystal structure guided array synthesis of PPARgamma inverse agonists.	Glaxosmithkline
17482722	22	QSAR analysis of PPAR-gamma agonists as anti-diabetic agents.	Central Drug Research Institute
21414782	178	Phenoxyacetic acids as PPARd partial agonists: synthesis, optimization, and in vivo efficacy.	Glaxosmithkline
20444603	2	Flexible ligand recognition of peroxisome proliferator-activated receptor-gamma (PPARgamma).	Rikkyo University
20128594	51	Identification and characterization of 4-chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide (GSK3787), a selective and irreversible peroxisome proliferator-activated receptor delta (PPARdelta) antagonist.	Glaxosmithkline
23186307	2	PPAR¿ agonist from Chromolaena odorata.	Hebei Medical University
23102891	34	Synthesis and structure-activity relationships of fibrate-based analogues inside PPARs.	Universit£
23084275	48	Design, synthesis and evaluation of novel zwitterionic compounds as PPARa/¿ dual agonists (1).	Daiichi Sankyo
22081932	32	Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity.	Istituto Tumori&Quot;Giovanni Paolo Ii&Quot
23130964	25	Design and synthesis of dual modulators of soluble epoxide hydrolase and peroxisome proliferator-activated receptors.	Zafes/Liff/Osf Goethe-University Frankfurt
22934537	4	Plakilactones from the marine sponge Plakinastrella mamillaris. Discovery of a new class of marine ligands of peroxisome proliferator-activated receptor¿.	Universit£
22424975	4	Sesquiterpene lactones from Tithonia diversifolia act as peroxisome proliferator-activated receptor agonists.	National Kaohsiung Normal University
23031596	21	Diarylheptanoid glycosides from Tacca plantaginea and their effects on NF-¿B activation and PPAR transcriptional activity.	Chungnam National University
23022278	14	Design, synthesis and in vitro evaluation of a series ofa-substituted phenylpropanoic acid PPAR¿ agonists to further investigate the stereochemistry-activity relationship.	Okayama University
21800856	50	Lignan derivatives from Krameria lappacea roots inhibit acute inflammation in vivo and pro-inflammatory mediators in vitro.	University Of Innsbruck
22324546	55	Synthesis and evaluation of sulfonylnitrophenylthiazoles (SNPTs) as thyroid hormone receptor-coactivator interaction inhibitors.	Institut Pasteur Korea
22260081	12	Targeting peroxisome proliferator-activated receptors (PPARs): development of modulators.	Universit£
22582973	21	Integrated virtual screening for the identification of novel and selective peroxisome proliferator-activated receptor (PPAR) scaffolds.	Trinity College
22727448	16	Synthesis and biological evaluation of novel (-)-Cercosporamide derivatives as potent selective PPAR¿ modulators.	Daiichi Sankyo
22564380	624	Activity landscape modeling of PPAR ligands with dual-activity difference maps.	Universidad Nacional Aut£Noma De M£Xico
22534184	87	Discovery, design and synthesis of Y-shaped peroxisome proliferator-activated receptord agonists as potent anti-obesity agents in vivo.	Seoul National University
22424300	3	Polyhydroxylated macrolides from Seimatosporium discosioides and their effects on the activation of peroxisome proliferator-activated receptor gamma.	Korea University
22579420	45	Total synthesis and dual PPARa/¿ agonist effects of amorphastilbol and its synthetic derivatives.	Korea Institute Of Science And Technology
22503460	37	Structure-activity relationships and key structural feature of pyridyloxybenzene-acylsulfonamides as new, potent, and selective peroxisome proliferator-activated receptor (PPAR)¿ Agonists.	Takeda Pharmaceutical
22381047	30	Anti-inflammatory and PPAR transactivational effects of secondary metabolites from the roots of Asarum sieboldii.	Chungnam National University
21218783	117	Identification of diaryl ether-based ligands for estrogen-related receptora as potential antidiabetic agents.	Johnson & Johnson Pharmaceutical Research And Development
21128600	16	Design, synthesis, and structural analysis of phenylpropanoic acid-type PPAR¿-selective agonists: discovery of reversed stereochemistry-activity relationship.	Okayama University
20527969	27	Design, synthesis, and structure-activity relationship studies of novel 2,4,6-trisubstituted-5-pyrimidinecarboxylic acids as peroxisome proliferator-activated receptor gamma (PPARgamma) partial agonists with comparable antidiabetic efficacy to rosiglitazone.	Kyorin Pharmaceutical
20299214	20	(S)-3-(4-(2-(5-Methyl-2-phenyloxazol-4-yl)ethoxy)phenyl)-2-(piperazin-1-yl) propanoic acid compounds: synthesis and biological evaluation of dual PPARalpha/gamma agonists.	Institute Of Pharmacology And Toxicology
20219371	22	Discovery of a novel selective PPARgamma modulator from (-)-Cercosporamide derivatives.	Daiichi Sankyo
19879669	3	Identification of (beta-carboxyethyl)-rhodanine derivatives exhibiting peroxisome proliferator-activated receptor gamma activity.	Sookmyung Women'S University
20138762	5	Acidic elements in histamine H(3) receptor antagonists.	Johann Wolfgang Goethe University
19574056	25	Discovery of novel dual functional agent as PPARgamma agonist and 11beta-HSD1 inhibitor for the treatment of diabetes.	Chinese Academy Of Sciences
18329752	14	Tryptophan-containing dipeptide derivatives as potent PPARgamma antagonists: design, synthesis, biological evaluation, and molecular modeling.	Graduate School Of The Chinese Academy Of Sciences
18976908	18	Modulation of PPAR receptor subtype selectivity of the ligands: aliphatic chain vs aromatic ring as a spacer between pharmacophore and the lipophilic moiety.	Zydus Research Centre
18826205	61	Design, synthesis, and biological evaluation of novel constrained meta-substituted phenyl propanoic acids as peroxisome proliferator-activated receptor alpha and gamma dual agonists.	Seoul National University
18511276	86	Design, synthesis, and structure-activity relationships of piperidine and dehydropiperidine carboxylic acids as novel, potent dual PPARalpha/gamma agonists.	Bristol-Myers Squibb R & D
18272370	2	Design, synthesis, biological evaluation and docking studies of pterostilbene analogs inside PPARalpha.	Usda-Ars
17062777	32	Comparative metabolism of radiolabeled muraglitazar in animals and humans by quantitative and qualitative metabolite profiling.	Bristol-Myers Squibb
18155554	87	Synthesis and structure-activity relationships of thiadiazole-derivatives as potent and orally active peroxisome proliferator-activated receptors alpha/delta dual agonists.	Johnson & Johnson Pharmaceutical Research And Development
17964792	31	Structure-activity studies on 1,3-dioxane-2-carboxylic acid derivatives, a novel class of subtype-selective peroxisome proliferator-activated receptor alpha (PPARalpha) agonists.	Nippon Shinyaku
18162399	37	SAR-oriented discovery of peroxisome proliferator-activated receptor pan agonist with a 4-adamantylphenyl group as a hydrophobic tail.	University Of Tokyo
18280733	27	Discovery of a novel class of 1,3-dioxane-2-carboxylic acid derivatives as subtype-selective peroxisome proliferator-activated receptor alpha (PPARalpha) agonists.	Nippon Shinyaku
18083521	4	Omega-(2-Naphthyloxy) amino alkanes as a novel class of anti-hyperglycemic and lipid lowering agents.	Central Drug Research Institute
18291645	108	Discovery of azetidinone acids as conformationally-constrained dual PPARalpha/gamma agonists.	Bristol-Myers Squibb Research And Development
18029176	66	Design and synthesis of indane-ureido-thioisobutyric acids: A novel class of PPARalpha agonists.	Johnson & Johnson
17560785	12	Design of a partial PPARdelta agonist.	Novo Nordisk
17010604	3	Structure-based de novo design, synthesis, and biological evaluation of the indole-based PPARgamma ligands (I).	Fudan University
17005393	35	Tetrahydroisoquinoline PPARgamma agonists: design of novel, highly selective non-TZD antihyperglycemic agents.	Eli Lilly
16821769	16	Design and synthesis of the first generation of dithiolane thiazolidinedione- and phenylacetic acid-based PPARgamma agonists.	University Of Mississippi
16220969	219	Designed multiple ligands. An emerging drug discovery paradigm.	Organon Laboratories
12951090	57	O-arylmandelic acids as highly selective human PPAR alpha/gamma agonists.	Merck Research Laboratories
10714503	18	Novel oximes having 5-benzyl-2,4-thiazolidinedione as antihyperglycemic agents: synthesis and structure-activity relationship.	Sankyo
22342624	2	Acetylenic acid analogues from the edible mushroom Chanterelle (Cantharellus cibarius) and their effects on the gene expression of peroxisome proliferator-activated receptor-gamma target genes.	Korea University
22341573	39	Synthesis, biological evaluation and molecular investigation of fluorinated peroxisome proliferator-activated receptorsa/¿ dual agonists.	Universit£
22225641	13	Substituents at the naphthalene C3 position of (-)-Cercosporamide derivatives significantly affect the maximal efficacy as PPAR¿ partial agonists.	Daiichi Sankyo
22070604	150	Benzimidazolones: a new class of selective peroxisome proliferator-activated receptor¿ (PPAR¿) modulators.	Merck Research Laboratories
22209730	73	A new class of non-thiazolidinedione, non-carboxylic-acid-based highly selective peroxisome proliferator-activated receptor (PPAR)¿ agonists: design and synthesis of benzylpyrazole acylsulfonamides.	Takeda Pharmaceutical
22197396	57	Novel (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids: peroxisome proliferator-activated receptor¿ selective agonists with protein-tyrosine phosphatase 1B inhibition.	Kyoto Pharmaceutical Industries
22133631	76	Discovery of cyclic amine-substituted benzoic acids as PPARa agonists.	Kyorin Pharmaceutical
22051054	18	Synthesis, molecular modeling studies and biological evaluation of fluorine substituted analogs of GW 501516.	University Of Oslo
21873070	29	SAR studies of acidic dual¿-secretase/PPAR¿ modulators.	Goethe-University Frankfurt
21514830	39	Peroxisome proliferator-activated receptor agonists with phenethylphenylphthalimide skeleton derived from thalidomide-related liver X receptor antagonists: relationship between absolute configuration and subtype selectivity.	The University Of Tokyo
21450468	22	Revisiting glitazars: thiophene substituted oxazole containinga-ethoxy phenylpropanoic acid derivatives as highly potent PPARa/¿ dual agonists devoid of adverse effects in rodents.	Zydus Research Centre
20850970	27	Novel thiazolidinedione derivatives with anti-obesity effects: dual action as PTP1B inhibitors and PPAR-¿ activators.	Inha University
21557540	39	Discovery of a series of imidazo[4,5-b]pyridines with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-¿.	Pfizer
21482446	55	Discovery of new nanomolar peroxisome proliferator-activated receptor κ activators via elaborate ligand-based modeling.	Universiti Sains Malaysia
19423341	6	Design, synthesis and insulin-sensitizing activity of indomethacin and diclofenac derivatives.	Guiyang Medical College
21530275	42	Structure-based design, synthesis, and nonalcoholic steatohepatitis (NASH)-preventive effect of phenylpropanoic acid peroxisome proliferator-activated receptor (PPAR)a-selective agonists.	Okayama University
21515063	60	Biological evaluation of novel benzisoxazole derivatives as PPARd agonists.	Nippon Chemiphar
21377875	19	Synthesis and pharmacological evaluation of novel benzoylazole-based PPARa/κ activators.	Dainippon Sumitomo Pharma
21094606	24	Discovery of isoindoline and tetrahydroisoquinoline derivatives as potent, selective PPARd agonists.	Astrazeneca R&D Charnwood
21130649	11	Development of a new class of benzoylpyrrole-based PPARa/¿ activators.	Dainippon Sumitomo Pharma
21112784	15	Synthesis of a novel human PPARd selective agonist and its stimulatory effect on oligodendrocyte differentiation.	Nippon Chemiphar
21215640	21	Effect of structurally constrained oxime-ether linker on PPAR subtype selectivity: Discovery of a novel and potent series of PPAR-pan agonists.	Zydus Research Centre
21074432	25	Selective peroxisome proliferator-activated receptord isosteric selenium agonists as potent anti-atherogenic agents in vivo.	Seoul National University
21030263	5	1,3-Diphenyl-1H-pyrazole derivatives as a new series of potent PPAR¿ partial agonists.	Sookmyung Women'S University
20656494	11	Characterization of new PPARgamma agonists: benzimidazole derivatives-importance of positions 5 and 6, and computational studies on the binding mode.	Freie UniversitäT Berlin
20638278	145	Synthesis and pharmacological validation of a novel series of non-steroidal FXR agonists.	Phenex Pharmaceuticals
20503989	29	Design, synthesis, and biological evaluation of a novel class of gamma-secretase modulators with PPARgamma activity.	Zafes/Liff/Goethe University Frankfurt
20471839	4	Synthesis and anti-inflammatory activity of new arylidene-thiazolidine-2,4-diones as PPARgamma ligands.	Universidade Federal De Pernambuco
20452212	26	Glycine amides as PPARalpha agonists.	Bayer-Schering Pharma
20356736	48	Synthesis and structure-activity relationships of 2-aryl-4-oxazolylmethoxy benzylglycines and 2-aryl-4-thiazolylmethoxy benzylglycines as novel, potent PPARalpha selective activators- PPARalpha and PPARgamma selectivity modulation.	Bristol-Myers Squibb R & D
20347594	7	Truxillic acid derivatives act as peroxisome proliferator-activated receptor gamma activators.	Goethe-University Frankfurt
20307981	16	Rational design of a pirinixic acid derivative that acts as subtype-selective PPARgamma modulator.	Goethe-University Frankfurt
20218621	131	Discovery of an oxybenzylglycine based peroxisome proliferator activated receptor alpha selective agonist 2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic acid (BMS-687453).	Bristol-Myers Squibb
19928766	425	Novel bisaryl substituted thiazoles and oxazoles as highly potent and selective peroxisome proliferator-activated receptor delta agonists.	The Genomics Institute Of The Novartis Research Foundation
19853439	21	Novel biphenylcarboxylic acid peroxisome proliferator-activated receptor (PPAR) delta selective antagonists.	The University Of Tokyo
20022492	29	Design and synthesis of novel bis-oximinoalkanoic acids as potent PPARalpha agonists.	Zydus Research Centre
20079636	78	Synthesis and biological activities of novel indole derivatives as potent and selective PPARgamma modulators.	Glaxosmithkline
19807106	11	7-Hydroxy-benzopyran-4-one derivatives: a novel pharmacophore of peroxisome proliferator-activated receptor alpha and -gamma (PPARalpha and gamma) dual agonists.	The University Of Sydney
19775169	41	New 2-aryloxy-3-phenyl-propanoic acids as peroxisome proliferator-activated receptors alpha/gamma dual agonists with improved potency and reduced adverse effects on skeletal muscle function.	Universit£
19556125	42	Discovery of a novel class of 2-mercaptohexanoic acid derivatives as highly active PPARalpha agonists.	Goethe-University Frankfurt
19719236	23	Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) by nitroalkene fatty acids: importance of nitration position and degree of unsaturation.	Wake Forest University
19376700	21	4,4-Dimethyl-1,2,3,4-tetrahydroquinoline-based PPARalpha/gamma agonists. Part. II: Synthesis and pharmacological evaluation of oxime and acidic head group structural variations.	Umr Gicc
19530681	79	Discovery of a peroxisome proliferator activated receptor gamma (PPARgamma) modulator with balanced PPARalpha activity for the treatment of type 2 diabetes and dyslipidemia.	Merck Research Laboratories
	22	Solid-phase synthesis of hybrid thiazolidinedione-fatty acid PPARγ ligands	TBA
	4	Non thiazolidinedione antihyperglycaemic agents. 2: α-Carbon substituted β-phenylpropanoic acids1	TBA
	9	Non thiazolidinedione antihyperglycaemic agents. 1: α-Heteroatom substituted β-phenylpropanoic acids	TBA
19507861	18	Discovery of (2R)-2-(3-{3-[(4-Methoxyphenyl)carbonyl]-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl}phenoxy)butanoic acid (MK-0533): a novel selective peroxisome proliferator-activated receptor gamma modulator for the treatment of type 2 diabetes mellitus with a reduced potential to increase plasma a	Merck Research Laboratories
19349176	137	Aleglitazar, a new, potent, and balanced dual PPARalpha/gamma agonist for the treatment of type II diabetes.	F. Hoffmann-La Roche
19301897	63	Design and structural analysis of novel pharmacophores for potent and selective peroxisome proliferator-activated receptor gamma agonists.	National Health Research Institutes
19275963	26	Selective, potent PPARgamma agonists with cyclopentenone core structure.	Universidade De Vigo
19201606	86	Design, synthesis and structure-activity relationships of azole acids as novel, potent dual PPAR alpha/gamma agonists.	Bristol-Myers Squibb Research And Development
18947994	102	The discovery of equipotent PPARalpha/gamma dual activators.	Glaxosmithkline
18835719	42	Synthesis, biological evaluation, and molecular modeling investigation of chiral 2-(4-chloro-phenoxy)-3-phenyl-propanoic acid derivatives with PPARalpha and PPARgamma agonist activity.	Università
18821746	10	Discovery of novel PPAR ligands by a virtual screening approach based on pharmacophore modeling, 3D shape, and electrostatic similarity screening.	University Of Innsbruck
18809325	13	Analogues of 2-phenyl-ethenesulfonic acid phenyl ester have dual functions of inhibiting expression of inducible nitric oxide synthase and activating peroxisome proliferator-activated receptor gamma.	National Health Research Institutes
18805005	8	Discovery of a highly orally bioavailable c-5-[6-(4-Methanesulfonyloxyphenyl)hexyl]-2-methyl-1,3-dioxane-r-2-carboxylic acid as a potent hypoglycemic and hypolipidemic agent.	Zydus Research Centre
18771917	68	Design, synthesis, and evaluation of novel aryl-tetrahydropyridine PPARalpha/gamma dual agonists.	Yuhan Research Institute
18701276	97	Highly functionalized 7-azaindoles as selective PPAR gamma modulators.	Merck Research Laboratories
18665581	23	Sulindac derivatives that activate the peroxisome proliferator-activated receptor gamma but lack cyclooxygenase inhibition.	Vanderbilt University Center For Structural Biology
18662876	45	Improvement of the transactivation activity of phenylpropanoic acid-type peroxisome proliferator-activated receptor pan agonists: effect of introduction of fluorine at the linker part.	The University Of Tokyo
18625559	16	Design and synthesis of novel oxazole containing 1,3-dioxane-2-carboxylic acid derivatives as PPAR alpha/gamma dual agonists.	Zydus Research Centre
18477507	1	Effects of amide constituents from pepper on adipogenesis in 3T3-L1 cells.	Kyoto Pharmaceutical University
18329751	40	Synthesis and evaluation of a series of benzopyran derivatives as PPAR alpha/gamma agonists.	Graduate School Of The Chinese Academy Of Sciences
18321611	64	CoMFA analysis of dual/multiple PPAR activators.	National Institute Of Pharmaceutical Education And Research
16643023	2	Bioassay for the identification of natural product-based activators of peroxisome proliferator-activated receptor-gamma (PPARgamma): the marine sponge metabolite psammaplin A activates PPARgamma and induces apoptosis in human breast tumor cells.	University Of Mississippi
11975517	3	Two new furanoditerpenes from Saururus chinenesis and their effects on the activation of peroxisome proliferator-activated receptor gamma.	Korea Research Institute Of Bioscience And Biotechnology
18255290	28	4,4-Dimethyl-1,2,3,4-tetrahydroquinoline-based PPARalpha/gamma agonists. Part I: synthesis and pharmacological evaluation.	Spot-Ea3857
18060776	100	Design, synthesis and evaluation of trifluoromethane sulfonamide derivatives as new potent and selective peroxisome proliferator-activated receptor alpha agonists.	Glaxosmithkline
18044841	12	Chlorocyclinones A-D, chlorinated angucyclinones from Streptomyces sp. strongly antagonizing rosiglitazone-induced PPAR-gamma activation.	Boehringer Ingelheim Pharma
18029178	188	Design and synthesis of novel and potent amide linked PPARgamma/delta dual agonists.	Eli Lilly
18023179	58	Carboxylic acid based quinolines as liver X receptor modulators that have LXRbeta receptor binding selectivity.	Wyeth Pharmaceuticals
17624777	31	Synthesis and structure-activity relationship of novel indene N-oxide derivatives as potent peroxisome proliferator activated receptor gamma (PPARgamma) agonists.	Korea Research Institute Of Chemical Technology
17618115	1	Mycophenolic acid as a latent agonist of PPARgamma.	Hokkaido University
17601734	102	Indanylacetic acids as PPAR-delta activator insulin sensitizers.	Bayer Research Center
17574414	15	Design and synthesis of 6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid derivatives as PPARgamma activators.	National Institute Of Pharmaceutical Education And Research
17553681	50	Novel selective PPARdelta agonists: optimization of activity by modification of alkynylallylic moiety.	Re&D Vufb
17553678	97	Design and synthesis of highly potent and selective human peroxisome proliferator-activated receptor alpha agonists.	Kowa
17532641	57	Design, synthesis, and evaluation of potent, structurally novel peroxisome proliferator-activated receptor (PPAR) delta-selective agonists.	University Of Tokyo
17524643	14	Phenylpropanoic acid derivatives bearing a benzothiazole ring as PPARdelta-selective agonists.	Nagoya City University
17524639	73	Discovery of para-alkylthiophenoxyacetic acids as a novel series of potent and selective PPARdelta agonists.	Johnson And Johnson Pharmaceutical Research And Development
17512197	101	Synthesis and SAR of selective benzothiophene, benzofuran, and indole-based peroxisome proliferator-activated receptor delta agonists.	Pfizer
17507225	34	Design, synthesis, and structure-activity relationship of carbamate-tethered aryl propanoic acids as novel PPARalpha/gamma dual agonists.	Seoul National University
17498950	69	Discovery of highly potent and selective benzyloxybenzyl-based peroxisome proliferator-activator receptor (PPAR) delta agonists.	Pfizer
17379517	45	Design of potent PPARalpha agonists.	Novo Nordisk
17343371	27	Identification and synthesis of a novel selective partial PPARdelta agonist with full efficacy on lipid metabolism in vitro and in vivo.	Novo Nordisk
17292606	91	Discovery of tertiary aminoacids as dual PPARalpha/gamma agonists-I.	Bristol-Myers Squibb Pharmaceutical Research Institute
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15771468	19	Design and synthesis of N-[(4-methoxyphenoxy)carbonyl]-N-[[4-[2-(5- methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]glycine [Muraglitazar/BMS-298585], a novel peroxisome proliferator-activated receptor alpha/gamma dual agonist with efficacious glucose and lipid-lowering activities.	Bristol-Myers Squibb Pharmaceutical Research Institute
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15177462	38	Design, synthesis, and evaluation of a new class of noncyclic 1,3-dicarbonyl compounds as PPARalpha selective activators.	Research Institute Of Tsinghua University
15163205	94	(2R)-2-ethylchromane-2-carboxylic acids: discovery of novel PPARalpha/gamma dual agonists as antihyperglycemic and hypolipidemic agents.	Merck Research Laboratories
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14695833	46	Benzoxazinones as PPARgamma agonists. 2. SAR of the amide substituent and in vivo results in a type 2 diabetes model.	Johnson And Johnson Pharmaceutical Research And Development
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14505666	99	Aryloxazolidinediones: identification of potent orally active PPAR dual alpha/gamma agonists.	Merck Research Laboratories
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12729668	106	5-Aryl thiazolidine-2,4-diones as selective PPARgamma agonists.	Merck Research Laboratories
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12443777	63	Synthesis and pharmacological evaluation of a new class of peroxisome proliferator-activated receptor modulators.	Biovitrum
11906293	7	Novel 5-substituted 2,4-thiazolidinedione and 2,4-oxazolidinedione derivatives as insulin sensitizers with antidiabetic activities.	Takeda Chemical Industries
11831892	46	Novel tricyclic-alpha-alkyloxyphenylpropionic acids: dual PPARalpha/gamma agonists with hypolipidemic and antidiabetic activity.	Novo Nordisk
11814790	8	Enantio-dependent binding and transactivation of optically active phenylpropanoic acid derivatives at human peroxisome proliferator-activated receptor alpha.	Kyorin Pharmaceutical
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11527737	70	Identification of a series of oxadiazole-substituted alpha-isopropoxy phenylpropanoic acids with activity on PPARalpha, PPARgamma, and PPARdelta.	Glaxosmithkline
11405642	33	Design and synthesis of 2-methyl-2-[4-(2-[5-methyl-2-aryloxazol-4-yl]ethoxy)phenoxy]propionic acids: a new class of dual PPARalpha/gamma agonists.	Eli Lilly
11354382	42	Identification of a subtype selective human PPARalpha agonist through parallel-array synthesis.	Glaxosmithkline
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10612594	32	Synthesis and biological activity of a novel series of indole-derived PPARgamma agonists.	Glaxo Wellcome Research And Development
10508427	42	A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARalpha agonist with potent lipid-lowering activity.	Glaxo Wellcome Research & Development
10098657	2	(3-substituted benzyl)thiazolidine-2,4-diones as structurally new antihyperglycemic agents.	Kyorin Pharmaceutical
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29446942	98	Design, Synthesis, and Evaluation of a Novel Series of Indole Sulfonamide Peroxisome Proliferator Activated Receptor (PPAR)?/?/? Triple Activators: Discovery of Lanifibranor, a New Antifibrotic Clinical Candidate.	Inventiva
29316397	47	Discovery of Potent and Orally Bioavailable Dihydropyrazole GPR40 Agonists.	Bristol-Myers Squibb
28539218	25	Switching subtype-selectivity: Fragment replacement strategy affords novel class of peroxisome proliferator-activated receptor?/? (PPAR?/?) dual agonists.	The University Of Tokyo
28465099	26	Structure-activity relationships of rosiglitazone for peroxisome proliferator-activated receptor gamma transrepression.	The University Of Tokyo
28845983	81	A Dual Modulator of Farnesoid X Receptor and Soluble Epoxide Hydrolase To Counter Nonalcoholic Steatohepatitis.	Goethe-University Frankfurt
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28485590	15	Structure-Activity Relationship of 2,4-Dichloro-N-(3,5-dichloro-4-(quinolin-3-yloxy)phenyl)benzenesulfonamide (INT131) Analogs for PPAR?-Targeted Antidiabetics.	The Scripps Research Institute
11160654	10	Pharmacological properties of the potent epileptogenic amino acid dysiherbaine, a novel glutamate receptor agonist isolated from the marine sponge Dysidea herbacea.	Kitasato University
10991998	32	Cannabinoid agonist signal transduction in rat brain: comparison of cannabinoid agonists in receptor binding, G-protein activation, and adenylyl cyclase inhibition.	Wake Forest University
21671327	5	Triptolide directly inhibits dCTP pyrophosphatase.	Yale University
8474008	58	Cannabinoid structure-activity relationships: correlation of receptor binding and in vivo activities.	Virginia Commonwealth University
20373302	5	The identification of a novel natural activator of p300 histone acetyltranferase provides new insights into the modulation mechanism of this enzyme.	Universitá
19827080	10	A fragment-based approach to probing adenosine recognition sites by using dynamic combinatorial chemistry.	University Of Cambridge
19954435	116	Heme oxygenase inhibition by 2-oxy-substituted 1-azolyl-4-phenylbutanes: effect of variation of the azole moiety. X-ray crystal structure of human heme oxygenase-1 in complex with 4-phenyl-1-(1H-1,2,4-triazol-1-yl)-2-butanone.	Queen'S University
19843080	43	The design, synthesis and potential utility of fluorescence probes that target DFG-out conformation of p38alpha for high throughput screening binding assay.	Pfizer
8461029	21	Characterization of recombinant human serotonin 5HT1A receptors expressed in Chinese hamster ovary cells. [3H]spiperone discriminates between the G-protein-coupled and -uncoupled forms.	University Of Canterbury
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